RPSAP58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ribosomal small subunit assembly (GO:0000028)5.46805852
2DNA deamination (GO:0045006)4.48026105
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.33071266
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.33071266
5NADH dehydrogenase complex assembly (GO:0010257)4.33071266
6respiratory chain complex IV assembly (GO:0008535)4.16461366
7protein complex biogenesis (GO:0070271)4.08170523
8replication fork processing (GO:0031297)4.03113710
9chaperone-mediated protein transport (GO:0072321)3.96963014
10chromatin remodeling at centromere (GO:0031055)3.94747542
11base-excision repair, AP site formation (GO:0006285)3.85591829
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.84457831
13CENP-A containing nucleosome assembly (GO:0034080)3.82380934
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.79838310
15mitochondrial respiratory chain complex assembly (GO:0033108)3.74724990
16viral transcription (GO:0019083)3.71556533
17translational termination (GO:0006415)3.67440792
18response to pheromone (GO:0019236)3.64676890
19cytochrome complex assembly (GO:0017004)3.63424396
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60353916
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.57370221
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.54679262
23termination of RNA polymerase III transcription (GO:0006386)3.54679262
24DNA double-strand break processing (GO:0000729)3.46663875
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44094627
26ATP synthesis coupled proton transport (GO:0015986)3.44094627
27translational elongation (GO:0006414)3.40076248
28positive regulation of cell size (GO:0045793)3.39235428
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37001053
30platelet dense granule organization (GO:0060155)3.36891856
31pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.36783136
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34131364
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34131364
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33539325
35cotranslational protein targeting to membrane (GO:0006613)3.32016525
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29238216
37regulation of mitochondrial translation (GO:0070129)3.26731189
38ribosomal large subunit biogenesis (GO:0042273)3.26210603
39protein targeting to ER (GO:0045047)3.25606986
40pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.24077773
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.23915737
42maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22723186
43proteasome assembly (GO:0043248)3.22654379
44water-soluble vitamin biosynthetic process (GO:0042364)3.22630345
45histone exchange (GO:0043486)3.16617476
46synapsis (GO:0007129)3.14743942
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.14102690
48CTP biosynthetic process (GO:0006241)3.12297436
49CTP metabolic process (GO:0046036)3.12297436
50protein-cofactor linkage (GO:0018065)3.12073510
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10881579
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10260105
53formation of translation preinitiation complex (GO:0001731)3.08511818
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08485157
55DNA strand renaturation (GO:0000733)3.08146110
56protein localization to endoplasmic reticulum (GO:0070972)3.07683340
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07318781
58ribosomal small subunit biogenesis (GO:0042274)3.05760616
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97477283
60deoxyribonucleotide catabolic process (GO:0009264)2.97298568
61maturation of SSU-rRNA (GO:0030490)2.96261788
62arginine catabolic process (GO:0006527)2.95226731
63pyrimidine nucleotide catabolic process (GO:0006244)2.95077948
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94159511
65resolution of meiotic recombination intermediates (GO:0000712)2.93662470
66deoxyribose phosphate catabolic process (GO:0046386)2.92858494
67translational initiation (GO:0006413)2.91798702
68regulation of protein glycosylation (GO:0060049)2.91042959
69respiratory electron transport chain (GO:0022904)2.90541811
70pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.90444649
71cellular component biogenesis (GO:0044085)2.88940663
72behavioral response to nicotine (GO:0035095)2.85576083
73myoblast migration (GO:0051451)2.85179264
74electron transport chain (GO:0022900)2.84172861
75protein neddylation (GO:0045116)2.83101468
76cellular ketone body metabolic process (GO:0046950)2.80944192
77reciprocal DNA recombination (GO:0035825)2.80796055
78reciprocal meiotic recombination (GO:0007131)2.80796055
79recombinational repair (GO:0000725)2.80483541
80* translation (GO:0006412)2.80007184
81double-strand break repair via homologous recombination (GO:0000724)2.75814802
82pseudouridine synthesis (GO:0001522)2.71718703
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71453869
84DNA replication-independent nucleosome organization (GO:0034724)2.70777779
85DNA replication-independent nucleosome assembly (GO:0006336)2.70777779
86negative regulation of DNA recombination (GO:0045910)2.70344076
87cellular protein complex disassembly (GO:0043624)2.69926215
88axoneme assembly (GO:0035082)2.68415492
89purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.66399233
90protein polyglutamylation (GO:0018095)2.65166012
912-deoxyribonucleotide metabolic process (GO:0009394)2.63868893
92ribonucleoprotein complex biogenesis (GO:0022613)2.62027846
93nucleotide salvage (GO:0043173)2.61668929
94regulation of oxidative phosphorylation (GO:0002082)2.61429273
95peptidyl-histidine modification (GO:0018202)2.61303147
96regulation of cellular respiration (GO:0043457)2.61116922
97* rRNA processing (GO:0006364)2.60362522
98deoxyribose phosphate metabolic process (GO:0019692)2.60225117
99dopamine transport (GO:0015872)2.59089020
100UMP biosynthetic process (GO:0006222)2.59006842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.30664605
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10807369
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.01495425
4EZH2_22144423_ChIP-Seq_EOC_Human3.51267324
5* ZNF274_21170338_ChIP-Seq_K562_Hela3.21009788
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.19688268
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05946212
8IGF1R_20145208_ChIP-Seq_DFB_Human2.96721310
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90334651
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63280400
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48450101
12E2F7_22180533_ChIP-Seq_HELA_Human2.39456531
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.37447035
14VDR_23849224_ChIP-Seq_CD4+_Human2.29171856
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.25173841
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10334300
17EWS_26573619_Chip-Seq_HEK293_Human2.09823729
18FOXP3_21729870_ChIP-Seq_TREG_Human2.09422929
19MYC_18940864_ChIP-ChIP_HL60_Human1.99252482
20FUS_26573619_Chip-Seq_HEK293_Human1.98471032
21ELK1_19687146_ChIP-ChIP_HELA_Human1.98139493
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94798113
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90429767
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88514964
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83375690
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79189202
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75575785
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75238567
29* VDR_22108803_ChIP-Seq_LS180_Human1.71258565
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.67052932
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.63151372
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60670005
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60077829
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59977115
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.59275613
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55182267
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53034863
38TTF2_22483619_ChIP-Seq_HELA_Human1.49665689
39TP53_22573176_ChIP-Seq_HFKS_Human1.49004182
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40936529
41P300_19829295_ChIP-Seq_ESCs_Human1.38879331
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.34699179
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34132454
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33698542
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30371675
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27746117
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.25759319
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25759319
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23751855
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23664677
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23467248
52* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23411581
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23353536
54SOX2_19829295_ChIP-Seq_ESCs_Human1.22772184
55NANOG_19829295_ChIP-Seq_ESCs_Human1.22772184
56GABP_19822575_ChIP-Seq_HepG2_Human1.21605613
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21361242
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21128722
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19507180
60IRF1_19129219_ChIP-ChIP_H3396_Human1.18500205
61* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18247363
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13928302
63CBP_20019798_ChIP-Seq_JUKART_Human1.13616465
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13616465
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13423452
66TAF15_26573619_Chip-Seq_HEK293_Human1.13074372
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09215237
68RNF2_27304074_Chip-Seq_NSC_Mouse1.02557709
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01539959
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01359340
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00619648
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.00340046
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00087880
74AR_20517297_ChIP-Seq_VCAP_Human0.99142510
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.98609431
76MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98258546
77* ER_23166858_ChIP-Seq_MCF-7_Human0.96921805
78GBX2_23144817_ChIP-Seq_PC3_Human0.96441367
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96238787
80NANOG_20526341_ChIP-Seq_ESCs_Human0.95675895
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.94189020
82* TCF4_22108803_ChIP-Seq_LS180_Human0.92196726
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.90697241
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.89337438
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89198844
86HOXB7_26014856_ChIP-Seq_BT474_Human0.88878092
87NCOR_22424771_ChIP-Seq_293T_Human0.87847296
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.87380181
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87236407
90* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86955177
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.86257278
92P53_21459846_ChIP-Seq_SAOS-2_Human0.85781823
93PHF8_20622853_ChIP-Seq_HELA_Human0.85122830
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84966567
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84920180
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.84750944
97DCP1A_22483619_ChIP-Seq_HELA_Human0.84558630
98TAF2_19829295_ChIP-Seq_ESCs_Human0.83719976
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83275234
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.82947086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.55374758
2MP0008877_abnormal_DNA_methylation3.70246551
3MP0006292_abnormal_olfactory_placode3.41367524
4MP0005645_abnormal_hypothalamus_physiol2.88300661
5MP0002234_abnormal_pharynx_morphology2.67044758
6MP0008058_abnormal_DNA_repair2.55219730
7MP0009379_abnormal_foot_pigmentation2.28921108
8MP0001529_abnormal_vocalization2.28815713
9MP0003718_maternal_effect2.25774283
10MP0004043_abnormal_pH_regulation2.13276291
11MP0000566_synostosis2.10425525
12MP0008872_abnormal_physiological_respon2.08183850
13MP0003123_paternal_imprinting2.04838204
14MP0003693_abnormal_embryo_hatching1.96644684
15MP0008995_early_reproductive_senescence1.95415779
16MP0003786_premature_aging1.88031692
17MP0010094_abnormal_chromosome_stability1.87352439
18MP0002938_white_spotting1.83417457
19MP0008789_abnormal_olfactory_epithelium1.80497546
20MP0006072_abnormal_retinal_apoptosis1.76577052
21MP0001764_abnormal_homeostasis1.71715600
22MP0003890_abnormal_embryonic-extraembry1.65841775
23MP0005551_abnormal_eye_electrophysiolog1.60227073
24MP0003283_abnormal_digestive_organ1.59053817
25MP0003937_abnormal_limbs/digits/tail_de1.56815464
26MP0005646_abnormal_pituitary_gland1.52111509
27MP0001661_extended_life_span1.49234437
28MP0005394_taste/olfaction_phenotype1.45887611
29MP0005499_abnormal_olfactory_system1.45887611
30MP0003567_abnormal_fetal_cardiomyocyte1.45411489
31MP0004142_abnormal_muscle_tone1.45036667
32MP0002102_abnormal_ear_morphology1.42356761
33MP0003121_genomic_imprinting1.41954803
34MP0005253_abnormal_eye_physiology1.39885476
35MP0006036_abnormal_mitochondrial_physio1.39358660
36MP0002132_abnormal_respiratory_system1.37038490
37MP0005389_reproductive_system_phenotype1.36032169
38MP0003186_abnormal_redox_activity1.34874223
39MP0005084_abnormal_gallbladder_morpholo1.34627437
40MP0003787_abnormal_imprinting1.31775182
41MP0001919_abnormal_reproductive_system1.29540865
42MP0006035_abnormal_mitochondrial_morpho1.29078119
43MP0001293_anophthalmia1.28492074
44MP0003315_abnormal_perineum_morphology1.28360753
45MP0004957_abnormal_blastocyst_morpholog1.27374347
46MP0004885_abnormal_endolymph1.27270697
47MP0002638_abnormal_pupillary_reflex1.27073346
48MP0004147_increased_porphyrin_level1.25957223
49MP0002233_abnormal_nose_morphology1.25141421
50MP0002837_dystrophic_cardiac_calcinosis1.24869638
51MP0003195_calcinosis1.22322249
52MP0002876_abnormal_thyroid_physiology1.19679592
53MP0002210_abnormal_sex_determination1.16076145
54MP0000631_abnormal_neuroendocrine_gland1.15715384
55MP0001905_abnormal_dopamine_level1.15257682
56MP0002163_abnormal_gland_morphology1.14979590
57MP0002277_abnormal_respiratory_mucosa1.14211912
58MP0003119_abnormal_digestive_system1.11320912
59MP0002095_abnormal_skin_pigmentation1.11274248
60MP0001119_abnormal_female_reproductive1.07581772
61MP0004133_heterotaxia1.07501680
62MP0002160_abnormal_reproductive_system1.06370820
63MP0001929_abnormal_gametogenesis1.01173380
64MP0000653_abnormal_sex_gland1.00076799
65MP0004742_abnormal_vestibular_system0.99432742
66MP0001873_stomach_inflammation0.99009035
67MP0000372_irregular_coat_pigmentation0.98396404
68MP0005075_abnormal_melanosome_morpholog0.95085518
69MP0000049_abnormal_middle_ear0.94413078
70MP0001145_abnormal_male_reproductive0.90292177
71MP0000516_abnormal_urinary_system0.90212259
72MP0005367_renal/urinary_system_phenotyp0.90212259
73MP0005671_abnormal_response_to0.89364948
74MP0002736_abnormal_nociception_after0.86830915
75MP0003698_abnormal_male_reproductive0.81183212
76MP0010368_abnormal_lymphatic_system0.80561315
77MP0003122_maternal_imprinting0.80220807
78MP0001485_abnormal_pinna_reflex0.79751142
79MP0004145_abnormal_muscle_electrophysio0.79508983
80MP0005174_abnormal_tail_pigmentation0.77247501
81MP0003938_abnormal_ear_development0.76768811
82MP0009745_abnormal_behavioral_response0.75080449
83MP0009697_abnormal_copulation0.73660684
84MP0008007_abnormal_cellular_replicative0.73280898
85MP0002751_abnormal_autonomic_nervous0.72861892
86MP0002127_abnormal_cardiovascular_syste0.72807142
87MP0008875_abnormal_xenobiotic_pharmacok0.72421651
88MP0002109_abnormal_limb_morphology0.72001293
89MP0002557_abnormal_social/conspecific_i0.70837799
90MP0009053_abnormal_anal_canal0.69546561
91MP0005220_abnormal_exocrine_pancreas0.69220932
92MP0005636_abnormal_mineral_homeostasis0.67366702
93MP0008932_abnormal_embryonic_tissue0.66910942
94MP0005195_abnormal_posterior_eye0.64477766
95MP0003111_abnormal_nucleus_morphology0.64153894
96MP0010307_abnormal_tumor_latency0.63471575
97MP0005167_abnormal_blood-brain_barrier0.63354562
98MP0003936_abnormal_reproductive_system0.62866282
99MP0002396_abnormal_hematopoietic_system0.62595470
100MP0001188_hyperpigmentation0.62173638

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.60357041
2Acute encephalopathy (HP:0006846)4.09505189
3Abnormal mitochondria in muscle tissue (HP:0008316)3.92430541
4Progressive macrocephaly (HP:0004481)3.81544684
5Mitochondrial inheritance (HP:0001427)3.63419029
6Increased CSF lactate (HP:0002490)3.46378897
7Hepatocellular necrosis (HP:0001404)3.40257917
8Increased hepatocellular lipid droplets (HP:0006565)3.37289748
9Pancreatic cysts (HP:0001737)3.33803287
10Lipid accumulation in hepatocytes (HP:0006561)3.28124985
11Hepatic necrosis (HP:0002605)3.27773827
12Pancreatic fibrosis (HP:0100732)3.20753647
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11097131
14Asplenia (HP:0001746)2.97755764
15Reticulocytopenia (HP:0001896)2.96913098
16Aplasia/Hypoplasia of the spleen (HP:0010451)2.92657040
17Cerebral edema (HP:0002181)2.90464293
18Renal Fanconi syndrome (HP:0001994)2.89523335
19Optic disc pallor (HP:0000543)2.72394095
20Autoimmune thrombocytopenia (HP:0001973)2.71770095
21Abnormality of midbrain morphology (HP:0002418)2.68049995
22Molar tooth sign on MRI (HP:0002419)2.68049995
23Ectopic kidney (HP:0000086)2.67568385
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63862161
25Abnormality of alanine metabolism (HP:0010916)2.63862161
26Hyperalaninemia (HP:0003348)2.63862161
27Chromsome breakage (HP:0040012)2.63026009
28B lymphocytopenia (HP:0010976)2.62968653
29Methylmalonic acidemia (HP:0002912)2.62074284
30Supernumerary spleens (HP:0009799)2.60912503
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51280229
32Abnormality of B cell number (HP:0010975)2.50694792
33True hermaphroditism (HP:0010459)2.50003414
34Absent thumb (HP:0009777)2.48562522
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.46992640
36Increased serum lactate (HP:0002151)2.43344918
37Abolished electroretinogram (ERG) (HP:0000550)2.42430091
38Colon cancer (HP:0003003)2.41983766
39Abnormality of the renal cortex (HP:0011035)2.41792565
40Congenital stationary night blindness (HP:0007642)2.40764399
41Hyperglycinemia (HP:0002154)2.40244581
42Meckel diverticulum (HP:0002245)2.36614548
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35395999
44Abnormality of chromosome stability (HP:0003220)2.33598439
45Abnormality of the ileum (HP:0001549)2.31249375
463-Methylglutaconic aciduria (HP:0003535)2.27904498
47Anal stenosis (HP:0002025)2.27303665
48Bile duct proliferation (HP:0001408)2.25715170
49Abnormal biliary tract physiology (HP:0012439)2.25715170
50Respiratory difficulties (HP:0002880)2.22576199
51Lip pit (HP:0100267)2.19932830
52Chronic bronchitis (HP:0004469)2.18994945
53Abnormal drinking behavior (HP:0030082)2.18433224
54Polydipsia (HP:0001959)2.18433224
55Constricted visual fields (HP:0001133)2.17386533
56Methylmalonic aciduria (HP:0012120)2.15690173
57Exertional dyspnea (HP:0002875)2.15420230
58Abnormality of urine glucose concentration (HP:0011016)2.10838751
59Glycosuria (HP:0003076)2.10838751
60Abnormal rod and cone electroretinograms (HP:0008323)2.10304136
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07379718
62Severe combined immunodeficiency (HP:0004430)2.06935168
63Intestinal fistula (HP:0100819)2.06742347
64Nephronophthisis (HP:0000090)2.06657933
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04437451
66Attenuation of retinal blood vessels (HP:0007843)2.04005334
67Abnormal respiratory motile cilium physiology (HP:0012261)2.02697878
68Pendular nystagmus (HP:0012043)2.02597293
69Thyroiditis (HP:0100646)1.99901946
70Lethargy (HP:0001254)1.99613230
71Triphalangeal thumb (HP:0001199)1.99104345
72Increased intramyocellular lipid droplets (HP:0012240)1.98690197
73Abnormality of DNA repair (HP:0003254)1.97476635
74Lactic acidosis (HP:0003128)1.95285116
75Abnormality of the preputium (HP:0100587)1.93291515
76Chronic hepatic failure (HP:0100626)1.92604408
77Abnormality of the renal medulla (HP:0100957)1.91860101
78Abnormality of macular pigmentation (HP:0008002)1.91193775
79Rhinitis (HP:0012384)1.89933330
80Anencephaly (HP:0002323)1.89845616
81Abnormality of serum amino acid levels (HP:0003112)1.88959273
82Renal cortical cysts (HP:0000803)1.87545828
83Decreased central vision (HP:0007663)1.86692164
84Aplastic anemia (HP:0001915)1.86283572
85Abnormal respiratory epithelium morphology (HP:0012253)1.85941630
86Abnormal respiratory motile cilium morphology (HP:0005938)1.85941630
87Macrocytic anemia (HP:0001972)1.85237005
88Postaxial foot polydactyly (HP:0001830)1.84297230
89Leukodystrophy (HP:0002415)1.83189934
90Medial flaring of the eyebrow (HP:0010747)1.81079165
91Cystic liver disease (HP:0006706)1.80534272
92Abnormality of renal resorption (HP:0011038)1.79132408
93Abnormality of the labia minora (HP:0012880)1.77310551
94Tubular atrophy (HP:0000092)1.77267450
95Median cleft lip (HP:0000161)1.76734109
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75661897
97Generalized aminoaciduria (HP:0002909)1.74843116
98Abnormality of cells of the erythroid lineage (HP:0012130)1.74059699
99CNS demyelination (HP:0007305)1.72503751
100Respiratory failure (HP:0002878)1.71523859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.45226459
2WNK43.15950620
3PBK3.05504621
4ZAK2.97220463
5BMPR1B2.54236066
6NUAK12.54127160
7STK392.49925715
8STK242.44736369
9TNIK2.43183790
10ACVR1B2.20839498
11PINK12.11068898
12WNK31.92528639
13MAP4K21.89653640
14STK161.82646664
15BRSK21.81516821
16CDC71.75188989
17TAF11.69606747
18CCNB11.66586832
19DYRK21.65209981
20VRK11.63310439
21GRK11.56149875
22PLK41.55851529
23CDK191.53539706
24MKNK21.53029111
25PLK31.52797045
26BUB11.35805946
27TTK1.35161760
28FRK1.29167193
29SRPK11.27894470
30BCKDK1.26438620
31TXK1.24827622
32CHEK21.23646532
33MST41.20259114
34WEE11.19805097
35PRKCQ1.14793701
36ADRBK21.09280570
37MKNK11.07492893
38PRKCH1.06243424
39EIF2AK31.04479274
40ILK1.02489466
41KDR0.97483790
42MAPK130.97311903
43TRIM280.96276119
44TSSK60.94158866
45PDK20.92313896
46CSNK1G10.92261010
47PLK20.92183405
48PASK0.89991819
49ADRBK10.89481949
50NME10.86649638
51PLK10.86342699
52RPS6KB20.83416881
53MINK10.82746726
54NLK0.82328392
55DAPK10.82151634
56MAP4K10.75940101
57MAPKAPK50.75691434
58BRSK10.75205754
59ATR0.73650402
60PNCK0.73320431
61CDK90.72274748
62CAMKK20.70705576
63TGFBR10.69007523
64EIF2AK20.68464054
65CAMK10.68153920
66WNK10.65953231
67CSNK1G30.65735636
68CSNK1G20.64269103
69INSRR0.62911437
70STK40.61787120
71NEK20.56934377
72JAK30.54383625
73MAP3K20.54255482
74DAPK20.52555968
75OXSR10.51908226
76TNK20.51872272
77ERBB30.51729287
78TLK10.50963723
79PRKCG0.50955592
80DYRK30.49815660
81EIF2AK10.49695485
82ATM0.46756845
83TEC0.44059995
84PKN10.43281934
85CSNK2A20.42489732
86NTRK20.42080262
87CDK30.41420753
88TIE10.41369784
89CSNK2A10.40629995
90TAOK30.39850179
91PRKCE0.39008403
92ERBB40.38052784
93PRKCI0.37403238
94RPS6KA60.37270319
95GRK50.37093217
96PRKCD0.36593154
97FLT30.35795161
98TESK20.35575368
99CAMK40.34281910
100AURKB0.33818676

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.71967773
2RNA polymerase_Homo sapiens_hsa030203.65478051
3Proteasome_Homo sapiens_hsa030503.26685199
4Oxidative phosphorylation_Homo sapiens_hsa001902.82508445
5Parkinsons disease_Homo sapiens_hsa050122.68245239
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57370081
7Non-homologous end-joining_Homo sapiens_hsa034502.43591716
8Homologous recombination_Homo sapiens_hsa034402.33782317
9Protein export_Homo sapiens_hsa030602.13752297
10Fanconi anemia pathway_Homo sapiens_hsa034602.09218947
11Mismatch repair_Homo sapiens_hsa034302.07158340
12DNA replication_Homo sapiens_hsa030302.05373197
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04081177
14Basal transcription factors_Homo sapiens_hsa030221.99283461
15Pyrimidine metabolism_Homo sapiens_hsa002401.93877317
16Huntingtons disease_Homo sapiens_hsa050161.88669699
17Base excision repair_Homo sapiens_hsa034101.86976667
18Phototransduction_Homo sapiens_hsa047441.84984256
19One carbon pool by folate_Homo sapiens_hsa006701.82150419
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71097823
21Nucleotide excision repair_Homo sapiens_hsa034201.69382525
22RNA degradation_Homo sapiens_hsa030181.68409266
23RNA transport_Homo sapiens_hsa030131.57626261
24Primary immunodeficiency_Homo sapiens_hsa053401.55933887
25Propanoate metabolism_Homo sapiens_hsa006401.52900477
26Alzheimers disease_Homo sapiens_hsa050101.50643010
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50316958
28Linoleic acid metabolism_Homo sapiens_hsa005911.48151269
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45127694
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44281730
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40008153
32Butanoate metabolism_Homo sapiens_hsa006501.39420175
33Steroid biosynthesis_Homo sapiens_hsa001001.33585759
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31870683
35Purine metabolism_Homo sapiens_hsa002301.31712846
36Peroxisome_Homo sapiens_hsa041461.21638505
37Fatty acid elongation_Homo sapiens_hsa000621.20595341
38Caffeine metabolism_Homo sapiens_hsa002321.20170848
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15299599
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13462194
41Cardiac muscle contraction_Homo sapiens_hsa042601.08639518
42Selenocompound metabolism_Homo sapiens_hsa004501.08203926
43Olfactory transduction_Homo sapiens_hsa047401.07212254
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03796823
45Folate biosynthesis_Homo sapiens_hsa007901.03564379
46Spliceosome_Homo sapiens_hsa030401.02100673
47Nitrogen metabolism_Homo sapiens_hsa009101.00346440
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99670697
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.99130622
50Ether lipid metabolism_Homo sapiens_hsa005650.96786695
51Arginine biosynthesis_Homo sapiens_hsa002200.95194935
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85295826
53Fat digestion and absorption_Homo sapiens_hsa049750.84047501
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.83449166
55Metabolic pathways_Homo sapiens_hsa011000.79737607
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77702427
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.77447754
58Glutathione metabolism_Homo sapiens_hsa004800.75692855
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75073066
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74763148
61Retinol metabolism_Homo sapiens_hsa008300.73681870
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72667882
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72105996
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68880250
65Chemical carcinogenesis_Homo sapiens_hsa052040.67906969
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.67853771
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65196331
68Pyruvate metabolism_Homo sapiens_hsa006200.64354003
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62888151
70Arachidonic acid metabolism_Homo sapiens_hsa005900.61957911
71mRNA surveillance pathway_Homo sapiens_hsa030150.61601852
72Arginine and proline metabolism_Homo sapiens_hsa003300.60639383
73Vitamin B6 metabolism_Homo sapiens_hsa007500.56263629
74Allograft rejection_Homo sapiens_hsa053300.51803787
75Vitamin digestion and absorption_Homo sapiens_hsa049770.51382855
76Type I diabetes mellitus_Homo sapiens_hsa049400.50722015
77Autoimmune thyroid disease_Homo sapiens_hsa053200.50701063
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.45851191
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45425460
80Glycerolipid metabolism_Homo sapiens_hsa005610.45322640
81Cell cycle_Homo sapiens_hsa041100.44182498
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.43872505
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43584952
84Taste transduction_Homo sapiens_hsa047420.42604035
85N-Glycan biosynthesis_Homo sapiens_hsa005100.39855745
86p53 signaling pathway_Homo sapiens_hsa041150.37800476
87Tryptophan metabolism_Homo sapiens_hsa003800.36717353
88Basal cell carcinoma_Homo sapiens_hsa052170.36079223
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36038186
90Hedgehog signaling pathway_Homo sapiens_hsa043400.34118213
91Asthma_Homo sapiens_hsa053100.33627766
92Sulfur metabolism_Homo sapiens_hsa009200.32521271
93Graft-versus-host disease_Homo sapiens_hsa053320.31281792
94Hematopoietic cell lineage_Homo sapiens_hsa046400.30731811
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.28919271
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26294931
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23093628
98Regulation of autophagy_Homo sapiens_hsa041400.21213888
99Sulfur relay system_Homo sapiens_hsa041220.21207368
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20871123

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