RPSAP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.76048337
2proteasome assembly (GO:0043248)4.97406690
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68955577
4ATP synthesis coupled proton transport (GO:0015986)4.68171550
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68171550
6ubiquinone biosynthetic process (GO:0006744)4.58744379
7ribosomal small subunit assembly (GO:0000028)4.55404301
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.45541934
9chaperone-mediated protein transport (GO:0072321)4.42724888
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33860910
11peptidyl-histidine modification (GO:0018202)4.31373214
12ubiquinone metabolic process (GO:0006743)4.02781018
13protein complex biogenesis (GO:0070271)4.01697468
14cytidine deamination (GO:0009972)3.92866439
15cytidine metabolic process (GO:0046087)3.92866439
16cytidine catabolic process (GO:0006216)3.92866439
17regulation of mitochondrial translation (GO:0070129)3.89122901
18respiratory electron transport chain (GO:0022904)3.86499323
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85155077
20electron transport chain (GO:0022900)3.84466030
21quinone biosynthetic process (GO:1901663)3.81284566
22pseudouridine synthesis (GO:0001522)3.77444607
23termination of RNA polymerase III transcription (GO:0006386)3.76816048
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.76816048
25mitochondrial respiratory chain complex assembly (GO:0033108)3.70356768
26maturation of SSU-rRNA (GO:0030490)3.70027351
27negative regulation of telomere maintenance (GO:0032205)3.66705963
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64357132
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60238833
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.58537925
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.58537925
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.55760712
33NADH dehydrogenase complex assembly (GO:0010257)3.55760712
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55760712
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.52194572
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48029262
37DNA damage response, detection of DNA damage (GO:0042769)3.30843844
38response to interferon-beta (GO:0035456)3.28254432
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24815588
40respiratory chain complex IV assembly (GO:0008535)3.23932929
41regulation of cellular amino acid metabolic process (GO:0006521)3.22722208
42DNA catabolic process, exonucleolytic (GO:0000738)3.21570003
43water-soluble vitamin biosynthetic process (GO:0042364)3.21262150
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.20226910
45negative regulation of ligase activity (GO:0051352)3.17364364
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17364364
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10918610
48cytochrome complex assembly (GO:0017004)3.10664101
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08826134
50spliceosomal snRNP assembly (GO:0000387)3.07023308
51translational termination (GO:0006415)3.04703439
52metallo-sulfur cluster assembly (GO:0031163)3.04108048
53iron-sulfur cluster assembly (GO:0016226)3.04108048
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03903125
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03903125
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03903125
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00452811
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00452811
59rRNA processing (GO:0006364)3.00149647
60translation (GO:0006412)2.99006832
61viral transcription (GO:0019083)2.98450802
62histone mRNA metabolic process (GO:0008334)2.98271162
63rRNA metabolic process (GO:0016072)2.97660453
64indole-containing compound catabolic process (GO:0042436)2.97306009
65indolalkylamine catabolic process (GO:0046218)2.97306009
66tryptophan catabolic process (GO:0006569)2.97306009
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.96826666
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96826666
69ribosomal small subunit biogenesis (GO:0042274)2.96582459
70response to pheromone (GO:0019236)2.96523019
71protein neddylation (GO:0045116)2.92896440
72signal transduction involved in cell cycle checkpoint (GO:0072395)2.92243687
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92046388
74dopamine transport (GO:0015872)2.90243657
75DNA double-strand break processing (GO:0000729)2.90072882
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87275520
77cotranslational protein targeting to membrane (GO:0006613)2.86161840
78rRNA modification (GO:0000154)2.84587142
79positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.84419262
80protein targeting to ER (GO:0045047)2.81778404
81DNA replication checkpoint (GO:0000076)2.77285432
82base-excision repair, AP site formation (GO:0006285)2.76972338
83cellular component biogenesis (GO:0044085)2.75342770
84tRNA processing (GO:0008033)2.75275548
85chromatin remodeling at centromere (GO:0031055)2.73505083
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70339297
87cellular response to interferon-beta (GO:0035458)2.70071211
88protein localization to endoplasmic reticulum (GO:0070972)2.69941963
89GTP biosynthetic process (GO:0006183)2.69238798
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68518325
91translational elongation (GO:0006414)2.67907294
92kynurenine metabolic process (GO:0070189)2.65016584
93establishment of protein localization to endoplasmic reticulum (GO:0072599)2.64986475
94somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61079998
95isotype switching (GO:0045190)2.61079998
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61079998
97CENP-A containing nucleosome assembly (GO:0034080)2.60503875
98purine nucleotide salvage (GO:0032261)2.59088546
99ncRNA processing (GO:0034470)2.58775070
100ncRNA metabolic process (GO:0034660)2.58302910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.80446098
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.76666845
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21958974
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.02689307
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32720586
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13348634
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11382827
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.96348571
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74656149
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73815323
11ELK1_19687146_ChIP-ChIP_HELA_Human2.69566068
12ZNF274_21170338_ChIP-Seq_K562_Hela2.64711454
13VDR_23849224_ChIP-Seq_CD4+_Human2.62680219
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61647966
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.47650943
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.40369109
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32532687
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25684612
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.23079440
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18749770
21FOXP3_21729870_ChIP-Seq_TREG_Human2.18604144
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.14235727
23EWS_26573619_Chip-Seq_HEK293_Human1.94863451
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90482453
25VDR_22108803_ChIP-Seq_LS180_Human1.86309823
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85270380
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74409142
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65598122
29FUS_26573619_Chip-Seq_HEK293_Human1.62105891
30TP53_22573176_ChIP-Seq_HFKS_Human1.62068725
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59920365
32DCP1A_22483619_ChIP-Seq_HELA_Human1.57994872
33MYC_18940864_ChIP-ChIP_HL60_Human1.53369592
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50038195
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.49118269
36E2F7_22180533_ChIP-Seq_HELA_Human1.45088793
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43008722
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42577436
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.41996033
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40225611
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36213946
42CBP_20019798_ChIP-Seq_JUKART_Human1.36213946
43GABP_19822575_ChIP-Seq_HepG2_Human1.35462007
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33396574
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.33034255
46PHF8_20622853_ChIP-Seq_HELA_Human1.29881263
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29692096
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29606800
49RBPJ_21746931_ChIP-Seq_IB4_Human1.29530435
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28621854
51CIITA_25753668_ChIP-Seq_RAJI_Human1.23362457
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22098055
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21770215
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20536492
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20440373
56TTF2_22483619_ChIP-Seq_HELA_Human1.20419708
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.19297984
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18604553
59P300_19829295_ChIP-Seq_ESCs_Human1.17900268
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.14525537
61ETV1_20927104_ChIP-Seq_GIST48_Human1.14463554
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09557104
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09463711
64CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09066695
65AR_20517297_ChIP-Seq_VCAP_Human1.08657769
66GATA3_26560356_Chip-Seq_TH2_Human1.08423880
67IRF1_19129219_ChIP-ChIP_H3396_Human1.08308918
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08215764
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07453447
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06970708
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05706148
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05641184
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.04707613
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04512487
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04468044
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03358800
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03030961
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02320987
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.01815794
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01773126
81NCOR_22424771_ChIP-Seq_293T_Human1.01195099
82SOX2_19829295_ChIP-Seq_ESCs_Human0.99322526
83NANOG_19829295_ChIP-Seq_ESCs_Human0.99322526
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.99273462
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99045820
86XRN2_22483619_ChIP-Seq_HELA_Human0.98993271
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98019683
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.95998999
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95998999
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95701742
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95242519
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95237626
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94951767
94ER_23166858_ChIP-Seq_MCF-7_Human0.94283348
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92438042
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92071387
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.91628609
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91048910
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89360481
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.88817072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.13384094
2MP0002138_abnormal_hepatobiliary_system4.54688427
3MP0005360_urolithiasis3.11181305
4MP0006292_abnormal_olfactory_placode3.05766951
5MP0008058_abnormal_DNA_repair2.86667355
6MP0003786_premature_aging2.39815360
7MP0009379_abnormal_foot_pigmentation2.26173648
8MP0001873_stomach_inflammation2.21808659
9MP0005671_abnormal_response_to2.16416021
10MP0008877_abnormal_DNA_methylation2.12646137
11MP0001968_abnormal_touch/_nociception2.01546060
12MP0008875_abnormal_xenobiotic_pharmacok1.90780036
13MP0008872_abnormal_physiological_respon1.90185840
14MP0002277_abnormal_respiratory_mucosa1.89326069
15MP0003252_abnormal_bile_duct1.80527146
16MP0004145_abnormal_muscle_electrophysio1.75072041
17MP0000372_irregular_coat_pigmentation1.74715095
18MP0004957_abnormal_blastocyst_morpholog1.74144365
19MP0002102_abnormal_ear_morphology1.73970821
20MP0002736_abnormal_nociception_after1.73089650
21MP0003806_abnormal_nucleotide_metabolis1.67838039
22MP0001348_abnormal_lacrimal_gland1.65329645
23MP0001188_hyperpigmentation1.62210085
24MP0001984_abnormal_olfaction1.47947428
25MP0003718_maternal_effect1.44750592
26MP0000685_abnormal_immune_system1.43270848
27MP0002160_abnormal_reproductive_system1.41077867
28MP0008995_early_reproductive_senescence1.38902067
29MP0004142_abnormal_muscle_tone1.38496978
30MP0000538_abnormal_urinary_bladder1.33350381
31MP0008057_abnormal_DNA_replication1.30454811
32MP0003567_abnormal_fetal_cardiomyocyte1.29812888
33MP0005389_reproductive_system_phenotype1.29722753
34MP0006276_abnormal_autonomic_nervous1.28667148
35MP0005646_abnormal_pituitary_gland1.26745562
36MP0001835_abnormal_antigen_presentation1.26229105
37MP0010094_abnormal_chromosome_stability1.26203622
38MP0010368_abnormal_lymphatic_system1.26185876
39MP0004147_increased_porphyrin_level1.24146261
40MP0003646_muscle_fatigue1.23450400
41MP0008007_abnormal_cellular_replicative1.19600604
42MP0009250_abnormal_appendicular_skeleto1.14765588
43MP0002163_abnormal_gland_morphology1.14046000
44MP0005551_abnormal_eye_electrophysiolog1.11747610
45MP0001919_abnormal_reproductive_system1.11197338
46MP0010386_abnormal_urinary_bladder1.09802215
47MP0001485_abnormal_pinna_reflex1.08110834
48MP0000647_abnormal_sebaceous_gland1.08001519
49MP0006035_abnormal_mitochondrial_morpho1.04319157
50MP0009697_abnormal_copulation1.04031884
51MP0003763_abnormal_thymus_physiology1.04017367
52MP0002876_abnormal_thyroid_physiology1.02009855
53MP0005377_hearing/vestibular/ear_phenot1.01367717
54MP0003878_abnormal_ear_physiology1.01367717
55MP0005332_abnormal_amino_acid1.01334960
56MP0004133_heterotaxia1.01266884
57MP0001905_abnormal_dopamine_level0.99856412
58MP0003693_abnormal_embryo_hatching0.98925190
59MP0003077_abnormal_cell_cycle0.97785982
60MP0003186_abnormal_redox_activity0.97286909
61MP0004043_abnormal_pH_regulation0.96328870
62MP0003936_abnormal_reproductive_system0.94538073
63MP0003111_abnormal_nucleus_morphology0.93793874
64MP0005220_abnormal_exocrine_pancreas0.90991616
65MP0002928_abnormal_bile_duct0.90764331
66MP0004885_abnormal_endolymph0.89935302
67MP0001119_abnormal_female_reproductive0.88967177
68MP0006036_abnormal_mitochondrial_physio0.87920644
69MP0002735_abnormal_chemical_nociception0.87498060
70MP0002095_abnormal_skin_pigmentation0.86224077
71MP0002210_abnormal_sex_determination0.85545958
72MP0008873_increased_physiological_sensi0.84875744
73MP0003950_abnormal_plasma_membrane0.83058420
74MP0009333_abnormal_splenocyte_physiolog0.82461343
75MP0001929_abnormal_gametogenesis0.80699464
76MP0002938_white_spotting0.78888308
77MP0005410_abnormal_fertilization0.78533425
78MP0003638_abnormal_response/metabolism_0.78269999
79MP0001764_abnormal_homeostasis0.78224191
80MP0008789_abnormal_olfactory_epithelium0.78134870
81MP0005387_immune_system_phenotype0.77837454
82MP0001790_abnormal_immune_system0.77837454
83MP0001270_distended_abdomen0.77054245
84MP0002132_abnormal_respiratory_system0.75481630
85MP0001293_anophthalmia0.75083208
86MP0009745_abnormal_behavioral_response0.72666135
87MP0000653_abnormal_sex_gland0.72219186
88MP0003303_peritoneal_inflammation0.71969960
89MP0005085_abnormal_gallbladder_physiolo0.71929011
90MP0000427_abnormal_hair_cycle0.71189089
91MP0001800_abnormal_humoral_immune0.70938828
92MP0008932_abnormal_embryonic_tissue0.70738318
93MP0000358_abnormal_cell_content/0.69946436
94MP0003937_abnormal_limbs/digits/tail_de0.69880323
95MP0006054_spinal_hemorrhage0.69606476
96MP0001663_abnormal_digestive_system0.69518016
97MP0006072_abnormal_retinal_apoptosis0.69103420
98MP0000049_abnormal_middle_ear0.68641422
99MP0005075_abnormal_melanosome_morpholog0.68626847
100MP0000631_abnormal_neuroendocrine_gland0.67672645

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.31615916
2Abnormal mitochondria in muscle tissue (HP:0008316)4.11474767
3Increased CSF lactate (HP:0002490)4.08303106
4Mitochondrial inheritance (HP:0001427)3.94658069
5Acute encephalopathy (HP:0006846)3.68177416
6Progressive macrocephaly (HP:0004481)3.63228552
7Increased hepatocellular lipid droplets (HP:0006565)3.53964620
8Hepatocellular necrosis (HP:0001404)3.44630525
9Aplastic anemia (HP:0001915)3.39824517
10Hepatic necrosis (HP:0002605)3.38442357
11Colon cancer (HP:0003003)3.27464333
12Increased serum lactate (HP:0002151)3.23451839
13Type II lissencephaly (HP:0007260)3.18374100
14Lipid accumulation in hepatocytes (HP:0006561)3.13309236
15Renal Fanconi syndrome (HP:0001994)3.05165832
16Cerebral edema (HP:0002181)2.99866074
17Increased intramyocellular lipid droplets (HP:0012240)2.96579713
18Pancreatic cysts (HP:0001737)2.89247586
19Oral leukoplakia (HP:0002745)2.73276920
20Lactic acidosis (HP:0003128)2.67342661
21Prostate neoplasm (HP:0100787)2.65715769
22Abnormality of alanine metabolism (HP:0010916)2.62471786
23Hyperalaninemia (HP:0003348)2.62471786
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62471786
25Congenital stationary night blindness (HP:0007642)2.60174565
26Constricted visual fields (HP:0001133)2.59742631
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57905990
28Optic disc pallor (HP:0000543)2.54458552
29Abnormal number of erythroid precursors (HP:0012131)2.52940298
30Pancreatic fibrosis (HP:0100732)2.51836695
31Generalized aminoaciduria (HP:0002909)2.50643876
32Absent thumb (HP:0009777)2.49670412
33True hermaphroditism (HP:0010459)2.49580965
34Severe combined immunodeficiency (HP:0004430)2.47503327
35Glycosuria (HP:0003076)2.35273542
36Abnormality of urine glucose concentration (HP:0011016)2.35273542
37Stomach cancer (HP:0012126)2.34822192
38Exertional dyspnea (HP:0002875)2.33317916
39Abnormality of cells of the erythroid lineage (HP:0012130)2.29502490
40Increased muscle lipid content (HP:0009058)2.27853701
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25474705
42Elevated erythrocyte sedimentation rate (HP:0003565)2.25047529
43Abnormality of the pons (HP:0007361)2.19766594
44Lethargy (HP:0001254)2.19679105
45Abnormality of the ileum (HP:0001549)2.18385938
46Attenuation of retinal blood vessels (HP:0007843)2.17426261
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17259687
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17259687
49Respiratory failure (HP:0002878)2.16919851
50Meckel diverticulum (HP:0002245)2.16805083
51Chronic hepatic failure (HP:0100626)2.16084678
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14842245
53Methylmalonic aciduria (HP:0012120)2.11554416
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.11424565
55Pancytopenia (HP:0001876)2.11256635
56Abnormality of midbrain morphology (HP:0002418)2.10801781
57Molar tooth sign on MRI (HP:0002419)2.10801781
58IgG deficiency (HP:0004315)2.09188991
59Hypoplasia of the radius (HP:0002984)2.08991218
60Reticulocytopenia (HP:0001896)2.07665715
61Hypophosphatemic rickets (HP:0004912)2.06155446
62Cleft eyelid (HP:0000625)2.04763887
63Concave nail (HP:0001598)2.04321841
64Abnormality of the prostate (HP:0008775)2.03803243
65Esophageal atresia (HP:0002032)2.03557722
66Thyroiditis (HP:0100646)2.03552124
67Cerebellar dysplasia (HP:0007033)2.02700431
68Leukodystrophy (HP:0002415)2.02530850
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.02466396
70Tubular atrophy (HP:0000092)2.00617348
71Asplenia (HP:0001746)1.98947843
72Medial flaring of the eyebrow (HP:0010747)1.98677612
73Nephronophthisis (HP:0000090)1.96994016
74Abnormality of the renal cortex (HP:0011035)1.96602086
75Methylmalonic acidemia (HP:0002912)1.95307618
76Hypoproteinemia (HP:0003075)1.94297967
77Respiratory difficulties (HP:0002880)1.93705605
78Renal cortical cysts (HP:0000803)1.93169523
79Cellular immunodeficiency (HP:0005374)1.91939609
80Macrocytic anemia (HP:0001972)1.90614495
81Abnormality of serum amino acid levels (HP:0003112)1.90522428
82Triphalangeal thumb (HP:0001199)1.89021034
83Aplasia/hypoplasia of the uterus (HP:0008684)1.88995314
84Abnormality of the renal collecting system (HP:0004742)1.88825267
85Exercise intolerance (HP:0003546)1.88312202
86Abnormality of DNA repair (HP:0003254)1.87082658
87Combined immunodeficiency (HP:0005387)1.86464317
88Congenital, generalized hypertrichosis (HP:0004540)1.85280592
89Forearm undergrowth (HP:0009821)1.85022278
90Abnormality of the preputium (HP:0100587)1.83225102
91Abnormality of renal resorption (HP:0011038)1.82745621
92Microretrognathia (HP:0000308)1.81976005
93Duplicated collecting system (HP:0000081)1.81558840
94Retinal dysplasia (HP:0007973)1.80871723
95Sclerocornea (HP:0000647)1.80585293
96Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79627839
97Abnormality of the labia minora (HP:0012880)1.78812541
98Progressive inability to walk (HP:0002505)1.78039460
99Hypoplasia of the uterus (HP:0000013)1.77873694
100Birth length less than 3rd percentile (HP:0003561)1.76854423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.47776412
2VRK23.04670497
3BUB12.97375513
4PBK2.96315792
5MAP4K12.77509972
6EIF2AK32.64042885
7FRK2.57550735
8NUAK12.32606841
9ZAK2.31450894
10KDR2.23233572
11BCKDK2.15723060
12CDK82.12822672
13VRK12.10500863
14CDK192.04180936
15GRK11.93265170
16TLK11.91425038
17TXK1.88466154
18MST41.85163482
19WNK31.76920294
20SRPK11.60720241
21OXSR11.60469773
22ADRBK21.57029158
23TGFBR11.53899916
24ITK1.53088126
25TAF11.41194752
26STK161.37373560
27TEC1.33299743
28CDC71.28272943
29WNK41.25514447
30TRIM281.24589794
31PRKCQ1.23599523
32TNIK1.23308499
33NME11.19739845
34MAP4K21.15963699
35MKNK21.15357369
36MUSK1.13865326
37PLK41.11073277
38FLT31.10078401
39MAPKAPK31.08022546
40INSRR1.00689369
41PLK31.00174388
42PRKD30.97595387
43NEK10.95276247
44PIK3CA0.86377769
45PLK10.84168096
46STK390.82460663
47FES0.80516005
48CHEK20.77407326
49WEE10.76777532
50IKBKB0.72670388
51STK38L0.71373469
52MKNK10.70740848
53NME20.69185399
54CDK90.68749251
55TSSK60.67534275
56PDK20.67232228
57STK40.66150266
58CSNK1G10.65747722
59DAPK10.64807836
60ATR0.62410654
61TAOK30.60415080
62CDK30.58472915
63DYRK20.58324282
64FGFR10.57714719
65AKT30.55791618
66PRKCE0.55410576
67MAP3K120.53203922
68MAPKAPK50.52499037
69ADRBK10.52314986
70ZAP700.51416143
71CSNK1G30.51413649
72EIF2AK10.50294762
73LIMK10.50016296
74BCR0.48676601
75PIM20.46837742
76CSNK2A20.46750390
77RPS6KA50.46529246
78FGFR20.46026222
79ERBB40.45915154
80CSNK1G20.45878501
81EIF2AK20.45432872
82BRSK20.44414870
83AURKA0.42690051
84LCK0.42316449
85CSNK2A10.41824371
86PRKCG0.40785218
87PIK3CG0.40549021
88AURKB0.40197206
89SYK0.39946741
90PASK0.39768072
91SIK20.39419632
92ATM0.38288461
93RPS6KA40.36112404
94PLK20.35414095
95MAPK130.34744826
96IGF1R0.34114068
97PNCK0.33779896
98BTK0.31764395
99PIM10.31595149
100GRK50.31153097

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.03397506
2Ribosome_Homo sapiens_hsa030103.49443550
3Oxidative phosphorylation_Homo sapiens_hsa001903.41369085
4RNA polymerase_Homo sapiens_hsa030203.24954707
5Parkinsons disease_Homo sapiens_hsa050123.03798836
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.88807878
7Asthma_Homo sapiens_hsa053102.78580209
8Allograft rejection_Homo sapiens_hsa053302.51250682
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34315298
10Autoimmune thyroid disease_Homo sapiens_hsa053202.34233272
11Protein export_Homo sapiens_hsa030602.21166264
12Homologous recombination_Homo sapiens_hsa034402.19100201
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.11902465
14Huntingtons disease_Homo sapiens_hsa050162.06734296
15Mismatch repair_Homo sapiens_hsa034302.01442718
16Base excision repair_Homo sapiens_hsa034101.95566362
17Graft-versus-host disease_Homo sapiens_hsa053321.90803268
18Primary immunodeficiency_Homo sapiens_hsa053401.84324175
19Alzheimers disease_Homo sapiens_hsa050101.81872533
20Fanconi anemia pathway_Homo sapiens_hsa034601.81076380
21DNA replication_Homo sapiens_hsa030301.73137379
22Type I diabetes mellitus_Homo sapiens_hsa049401.71777741
23RNA degradation_Homo sapiens_hsa030181.57884925
24Pyrimidine metabolism_Homo sapiens_hsa002401.55940773
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54532107
26Antigen processing and presentation_Homo sapiens_hsa046121.48845584
27Basal transcription factors_Homo sapiens_hsa030221.38121523
28Nitrogen metabolism_Homo sapiens_hsa009101.36293693
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35536165
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33971343
31Nucleotide excision repair_Homo sapiens_hsa034201.32414806
32Selenocompound metabolism_Homo sapiens_hsa004501.26651096
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21863205
34Spliceosome_Homo sapiens_hsa030401.21460230
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20047118
36Cardiac muscle contraction_Homo sapiens_hsa042601.13776867
37Purine metabolism_Homo sapiens_hsa002301.12881215
38One carbon pool by folate_Homo sapiens_hsa006701.11564399
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07028747
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.06995729
41Propanoate metabolism_Homo sapiens_hsa006401.02205108
42RNA transport_Homo sapiens_hsa030131.01144865
43Tryptophan metabolism_Homo sapiens_hsa003801.01086337
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95111012
45Phototransduction_Homo sapiens_hsa047440.93885155
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88877248
47Peroxisome_Homo sapiens_hsa041460.86221967
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85413824
49Systemic lupus erythematosus_Homo sapiens_hsa053220.83696493
50Sulfur metabolism_Homo sapiens_hsa009200.83253959
51Hematopoietic cell lineage_Homo sapiens_hsa046400.82084465
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81060526
53Sulfur relay system_Homo sapiens_hsa041220.76487387
54Fatty acid elongation_Homo sapiens_hsa000620.76427080
55Linoleic acid metabolism_Homo sapiens_hsa005910.75058847
56Rheumatoid arthritis_Homo sapiens_hsa053230.74989003
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73473026
58Chemical carcinogenesis_Homo sapiens_hsa052040.73471887
59Caffeine metabolism_Homo sapiens_hsa002320.72456659
60Non-homologous end-joining_Homo sapiens_hsa034500.68555449
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67454885
62T cell receptor signaling pathway_Homo sapiens_hsa046600.65928130
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64888439
64Olfactory transduction_Homo sapiens_hsa047400.61994545
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61198890
66Butanoate metabolism_Homo sapiens_hsa006500.60779576
67Viral myocarditis_Homo sapiens_hsa054160.60285102
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59394477
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.56499535
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56364542
71Metabolic pathways_Homo sapiens_hsa011000.56015791
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55520995
73Folate biosynthesis_Homo sapiens_hsa007900.55445556
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54520215
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52655707
76Pyruvate metabolism_Homo sapiens_hsa006200.49745987
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45627706
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.40936782
79Epstein-Barr virus infection_Homo sapiens_hsa051690.40549383
80Herpes simplex infection_Homo sapiens_hsa051680.39822425
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38959940
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.38750999
83Glutathione metabolism_Homo sapiens_hsa004800.38615665
84Retinol metabolism_Homo sapiens_hsa008300.36894511
85beta-Alanine metabolism_Homo sapiens_hsa004100.34967871
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.33122336
87Fat digestion and absorption_Homo sapiens_hsa049750.32569343
88Staphylococcus aureus infection_Homo sapiens_hsa051500.31700861
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30687468
90Fatty acid degradation_Homo sapiens_hsa000710.30644337
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30631487
92Leishmaniasis_Homo sapiens_hsa051400.25892539
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25140772
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24543364
95Vitamin B6 metabolism_Homo sapiens_hsa007500.23163113
96Collecting duct acid secretion_Homo sapiens_hsa049660.22504893
97Regulation of autophagy_Homo sapiens_hsa041400.21265271
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19715729
99Measles_Homo sapiens_hsa051620.19144684
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18785792

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