ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.66942365
2	ribosomal small subunit assembly (GO:0000028)	9.57172585
3	viral transcription (GO:0019083)	8.49278681
4	translational termination (GO:0006415)	8.14639935
5	maturation of SSU-rRNA (GO:0030490)	7.11603078
6	translational elongation (GO:0006414)	7.11235690
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.08302393
8	cotranslational protein targeting to membrane (GO:0006613)	6.99551860
9	protein targeting to ER (GO:0045047)	6.94315892
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.67895444
11	protein localization to endoplasmic reticulum (GO:0070972)	6.52745201
12	viral life cycle (GO:0019058)	6.26247985
13	cellular protein complex disassembly (GO:0043624)	6.25294922
14	ATP synthesis coupled proton transport (GO:0015986)	6.07008419
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.07008419
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.04047035
17	ribosomal large subunit biogenesis (GO:0042273)	5.79106441
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.77728144
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.75162178
20	translational initiation (GO:0006413)	5.70973047
21	ncRNA 3-end processing (GO:0043628)	5.32668470
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.32467243
23	protein complex disassembly (GO:0043241)	5.21410935
24	chaperone-mediated protein transport (GO:0072321)	4.99045977
25	ribonucleoprotein complex biogenesis (GO:0022613)	4.98183533
26	macromolecular complex disassembly (GO:0032984)	4.94063820
27	translation (GO:0006412)	4.83341095
28	protein targeting to membrane (GO:0006612)	4.64256291
29	DNA deamination (GO:0045006)	4.57284693
30	cellular component biogenesis (GO:0044085)	4.54853768
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.54489922
32	NADH dehydrogenase complex assembly (GO:0010257)	4.54489922
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.54489922
34	respiratory electron transport chain (GO:0022904)	4.51119162
35	electron transport chain (GO:0022900)	4.46104159
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.40393385
37	protein complex biogenesis (GO:0070271)	4.33878009
38	mRNA catabolic process (GO:0006402)	4.13541508
39	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.06022231
40	water-soluble vitamin biosynthetic process (GO:0042364)	4.01046460
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97713558
42	protein neddylation (GO:0045116)	3.93012182
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.79987241
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79368897
45	RNA catabolic process (GO:0006401)	3.76995364
46	behavioral response to nicotine (GO:0035095)	3.71726997
47	rRNA processing (GO:0006364)	3.68449395
48	GTP biosynthetic process (GO:0006183)	3.64186685
49	rRNA metabolic process (GO:0016072)	3.60261605
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.56275973
51	ATP biosynthetic process (GO:0006754)	3.53777853
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.51089091
53	termination of RNA polymerase III transcription (GO:0006386)	3.47304597
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.47304597
55	intracellular protein transmembrane import (GO:0044743)	3.37682318
56	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.28196034
57	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.27902298
58	UTP biosynthetic process (GO:0006228)	3.26373821
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.24419760
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.24419760
61	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.23492779
62	hydrogen ion transmembrane transport (GO:1902600)	3.23270709
63	protein targeting (GO:0006605)	3.22649265
64	establishment of protein localization to membrane (GO:0090150)	3.17180964
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.16355659
66	UTP metabolic process (GO:0046051)	3.13578168
67	ribosome biogenesis (GO:0042254)	3.08393217
68	protein targeting to mitochondrion (GO:0006626)	3.05079785
69	respiratory chain complex IV assembly (GO:0008535)	3.03815439
70	peptidyl-histidine modification (GO:0018202)	3.00558367
71	pseudouridine synthesis (GO:0001522)	2.97953286
72	establishment of protein localization to mitochondrion (GO:0072655)	2.97254115
73	establishment of protein localization to organelle (GO:0072594)	2.96827020
74	proton transport (GO:0015992)	2.83413421
75	protein localization to mitochondrion (GO:0070585)	2.77371948
76	hydrogen transport (GO:0006818)	2.76983152
77	protein-cofactor linkage (GO:0018065)	2.75247987
78	nucleoside triphosphate biosynthetic process (GO:0009142)	2.75174644
79	cytochrome complex assembly (GO:0017004)	2.72636665
80	ncRNA processing (GO:0034470)	2.71576952
81	DNA damage response, detection of DNA damage (GO:0042769)	2.71245880
82	regulation of mitochondrial translation (GO:0070129)	2.69312630
83	protein peptidyl-prolyl isomerization (GO:0000413)	2.68732803
84	pyrimidine nucleotide catabolic process (GO:0006244)	2.66635835
85	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.65978119
86	base-excision repair, AP site formation (GO:0006285)	2.61963110
87	tRNA processing (GO:0008033)	2.61720578
88	formation of translation preinitiation complex (GO:0001731)	2.60937833
89	CTP biosynthetic process (GO:0006241)	2.58808178
90	CTP metabolic process (GO:0046036)	2.58808178
91	ncRNA metabolic process (GO:0034660)	2.58335136
92	guanosine-containing compound biosynthetic process (GO:1901070)	2.58180293
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.56983087
94	protein localization to membrane (GO:0072657)	2.54588604
95	proteasome assembly (GO:0043248)	2.51254970
96	inner mitochondrial membrane organization (GO:0007007)	2.50878703
97	RNA phosphodiester bond hydrolysis (GO:0090501)	2.48244043
98	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.47584344
99	anterograde synaptic vesicle transport (GO:0048490)	2.47570062
100	intracellular protein transmembrane transport (GO:0065002)	2.43820974

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.45104931
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.61002774
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.50012990
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.07322271
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63118426
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.53821964
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.34876503
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.15089345
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12695376
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.11246226
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.95930707
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.31005101
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.30724224
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23385535
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.21074530
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20735887
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17598463
18	TTF2_22483619_ChIP-Seq_HELA_Human	2.13397400
19	VDR_22108803_ChIP-Seq_LS180_Human	2.12496709
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.08377325
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.08171539
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05285429
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.04859470
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.00548637
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00317522
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.86301075
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85602164
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.72352647
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.68863638
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67615126
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.62047425
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.61621713
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.60944411
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.58015409
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57985832
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.57775440
37	EWS_26573619_Chip-Seq_HEK293_Human	1.54882007
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.53721162
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52866745
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.51379412
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49821540
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38145000
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36315807
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35118060
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35044518
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.32903473
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.32297014
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.31594852
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30549084
50	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.26574131
51	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17893515
52	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.13832612
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.08014156
54	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07773185
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07682022
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07636626
57	IGF1R_20145208_ChIP-Seq_DFB_Human	1.07103893
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06064234
59	FUS_26573619_Chip-Seq_HEK293_Human	1.06054361
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05859132
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05271093
62	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.05038692
63	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03984872
64	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03869962
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03497037
66	ERA_21632823_ChIP-Seq_H3396_Human	1.03459643
67	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.99971423
68	NCOR_22424771_ChIP-Seq_293T_Human	0.99968631
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.97914432
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97403063
71	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96080372
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95281633
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95281633
74	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95138221
75	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95061801
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94318192
77	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.93508465
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93146669
79	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92431607
80	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92398215
81	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90418284
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90316492
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.90099659
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89872431
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89679258
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89053304
87	AR_20517297_ChIP-Seq_VCAP_Human	0.88539569
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88418281
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.87765098
90	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.87236981
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86909890
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86049460
93	KDM5A_27292631_Chip-Seq_BREAST_Human	0.85777172
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85652509
95	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.84351691
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.83276225
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.82944327
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.81485567
99	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.81189790
100	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.80617143

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.54658280
2	MP0006292_abnormal_olfactory_placode	4.28584305
3	MP0001986_abnormal_taste_sensitivity	2.69980558
4	MP0003123_paternal_imprinting	2.60880393
5	MP0002163_abnormal_gland_morphology	2.49393947
6	MP0008877_abnormal_DNA_methylation	2.45401898
7	MP0003121_genomic_imprinting	2.04463825
8	MP0008789_abnormal_olfactory_epithelium	2.02189812
9	MP0003878_abnormal_ear_physiology	1.96230140
10	MP0005377_hearing/vestibular/ear_phenot	1.96230140
11	MP0001485_abnormal_pinna_reflex	1.94667439
12	MP0004142_abnormal_muscle_tone	1.94131939
13	MP0002837_dystrophic_cardiac_calcinosis	1.92053104
14	MP0001968_abnormal_touch/_nociception	1.85900934
15	MP0003787_abnormal_imprinting	1.85628730
16	MP0002102_abnormal_ear_morphology	1.78563141
17	MP0004147_increased_porphyrin_level	1.78523586
18	MP0005084_abnormal_gallbladder_morpholo	1.75531104
19	MP0004885_abnormal_endolymph	1.74207948
20	MP0003122_maternal_imprinting	1.73214532
21	MP0003693_abnormal_embryo_hatching	1.71663159
22	MP0005551_abnormal_eye_electrophysiolog	1.69619617
23	MP0002160_abnormal_reproductive_system	1.63842819
24	MP0001293_anophthalmia	1.63110976
25	MP0002736_abnormal_nociception_after	1.62166197
26	MP0000049_abnormal_middle_ear	1.62072295
27	MP0002653_abnormal_ependyma_morphology	1.60621013
28	MP0000372_irregular_coat_pigmentation	1.57374622
29	MP0008872_abnormal_physiological_respon	1.55749037
30	MP0005379_endocrine/exocrine_gland_phen	1.54569647
31	MP0005394_taste/olfaction_phenotype	1.51889907
32	MP0005499_abnormal_olfactory_system	1.51889907
33	MP0005646_abnormal_pituitary_gland	1.49260543
34	MP0001873_stomach_inflammation	1.48373145
35	MP0004742_abnormal_vestibular_system	1.47252942
36	MP0002638_abnormal_pupillary_reflex	1.46257313
37	MP0002938_white_spotting	1.42347281
38	MP0003567_abnormal_fetal_cardiomyocyte	1.38263091
39	MP0006072_abnormal_retinal_apoptosis	1.37651009
40	MP0008875_abnormal_xenobiotic_pharmacok	1.36365548
41	MP0003879_abnormal_hair_cell	1.35180121
42	MP0002277_abnormal_respiratory_mucosa	1.33371707
43	MP0001905_abnormal_dopamine_level	1.33176513
44	MP0006276_abnormal_autonomic_nervous	1.30486874
45	MP0003186_abnormal_redox_activity	1.28876363
46	MP0002138_abnormal_hepatobiliary_system	1.25944006
47	MP0000631_abnormal_neuroendocrine_gland	1.25247826
48	MP0002272_abnormal_nervous_system	1.23753423
49	MP0002095_abnormal_skin_pigmentation	1.22781290
50	MP0003646_muscle_fatigue	1.21232053
51	MP0005645_abnormal_hypothalamus_physiol	1.21209026
52	MP0004145_abnormal_muscle_electrophysio	1.19608727
53	MP0005389_reproductive_system_phenotype	1.17951175
54	MP0005671_abnormal_response_to	1.15742236
55	MP0003011_delayed_dark_adaptation	1.14365125
56	MP0001727_abnormal_embryo_implantation	1.13929266
57	MP0009333_abnormal_splenocyte_physiolog	1.12123108
58	MP0008058_abnormal_DNA_repair	1.11728706
59	MP0001529_abnormal_vocalization	1.10410561
60	MP0002210_abnormal_sex_determination	1.06195810
61	MP0003136_yellow_coat_color	1.04482656
62	MP0003938_abnormal_ear_development	1.04222946
63	MP0001188_hyperpigmentation	1.03299112
64	MP0000026_abnormal_inner_ear	1.03247089
65	MP0005174_abnormal_tail_pigmentation	1.02361410
66	MP0009745_abnormal_behavioral_response	1.01137194
67	MP0005195_abnormal_posterior_eye	0.98152001
68	MP0002234_abnormal_pharynx_morphology	0.95125461
69	MP0003283_abnormal_digestive_organ	0.93562258
70	MP0005360_urolithiasis	0.92887155
71	MP0003937_abnormal_limbs/digits/tail_de	0.92639107
72	MP0002752_abnormal_somatic_nervous	0.92041779
73	MP0003880_abnormal_central_pattern	0.91038764
74	MP0004510_myositis	0.90230758
75	MP0003718_maternal_effect	0.89668381
76	MP0002557_abnormal_social/conspecific_i	0.86648941
77	MP0002876_abnormal_thyroid_physiology	0.86384814
78	MP0002733_abnormal_thermal_nociception	0.84577026
79	MP0004133_heterotaxia	0.83286379
80	MP0001963_abnormal_hearing_physiology	0.82068789
81	MP0004957_abnormal_blastocyst_morpholog	0.81728945
82	MP0006036_abnormal_mitochondrial_physio	0.80947492
83	MP0001984_abnormal_olfaction	0.80872403
84	MP0000778_abnormal_nervous_system	0.79974343
85	MP0003315_abnormal_perineum_morphology	0.78669396
86	MP0001348_abnormal_lacrimal_gland	0.78411247
87	MP0002233_abnormal_nose_morphology	0.77142558
88	MP0009053_abnormal_anal_canal	0.76968041
89	MP0001145_abnormal_male_reproductive	0.76143769
90	MP0000653_abnormal_sex_gland	0.75959846
91	MP0001764_abnormal_homeostasis	0.75563584
92	MP0001970_abnormal_pain_threshold	0.74242977
93	MP0002735_abnormal_chemical_nociception	0.74123889
94	MP0001929_abnormal_gametogenesis	0.73994853
95	MP0005253_abnormal_eye_physiology	0.73049209
96	MP0001919_abnormal_reproductive_system	0.72638629
97	MP0005410_abnormal_fertilization	0.70691836
98	MP0002067_abnormal_sensory_capabilities	0.70300141
99	MP0003936_abnormal_reproductive_system	0.69521378
100	MP0001286_abnormal_eye_development	0.69306065

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.00280528
2	Acute necrotizing encephalopathy (HP:0006965)	4.96358885
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.62436526
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35887259
5	Acute encephalopathy (HP:0006846)	4.29034255
6	Mitochondrial inheritance (HP:0001427)	4.23278794
7	Macrocytic anemia (HP:0001972)	4.11360234
8	Septo-optic dysplasia (HP:0100842)	4.05414117
9	Progressive macrocephaly (HP:0004481)	3.99633672
10	Increased CSF lactate (HP:0002490)	3.87457175
11	Abnormal number of erythroid precursors (HP:0012131)	3.87445826
12	Increased hepatocellular lipid droplets (HP:0006565)	3.50600735
13	Constricted visual fields (HP:0001133)	3.45281102
14	Hepatic necrosis (HP:0002605)	3.29403736
15	Hepatocellular necrosis (HP:0001404)	3.29356837
16	Cerebral edema (HP:0002181)	3.24935808
17	Pallor (HP:0000980)	3.20894819
18	Optic disc pallor (HP:0000543)	3.16953120
19	Lipid accumulation in hepatocytes (HP:0006561)	3.11153797
20	Pendular nystagmus (HP:0012043)	3.09110298
21	Abnormality of midbrain morphology (HP:0002418)	3.06859199
22	Molar tooth sign on MRI (HP:0002419)	3.06859199
23	Hyperglycinemia (HP:0002154)	3.01720146
24	3-Methylglutaconic aciduria (HP:0003535)	2.99872861
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97750793
26	Abnormality of the labia minora (HP:0012880)	2.91037691
27	Renal Fanconi syndrome (HP:0001994)	2.87495551
28	Type II lissencephaly (HP:0007260)	2.87023504
29	Pancreatic fibrosis (HP:0100732)	2.72417137
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70229932
31	Increased serum lactate (HP:0002151)	2.64616697
32	Aplastic anemia (HP:0001915)	2.57988255
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.57210945
34	Congenital stationary night blindness (HP:0007642)	2.56510835
35	Pancreatic cysts (HP:0001737)	2.51871974
36	True hermaphroditism (HP:0010459)	2.50624719
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.43473011
38	Asplenia (HP:0001746)	2.43395215
39	Increased intramyocellular lipid droplets (HP:0012240)	2.42422892
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.41690418
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.41690418
42	Colon cancer (HP:0003003)	2.40845319
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40820149
44	Absent thumb (HP:0009777)	2.37119478
45	Attenuation of retinal blood vessels (HP:0007843)	2.36717449
46	Lactic acidosis (HP:0003128)	2.36081958
47	Absent septum pellucidum (HP:0001331)	2.32794702
48	Abnormality of macular pigmentation (HP:0008002)	2.30764592
49	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.29088204
50	Nephronophthisis (HP:0000090)	2.24191844
51	Optic nerve hypoplasia (HP:0000609)	2.21214585
52	Respiratory failure (HP:0002878)	2.20312214
53	Sclerocornea (HP:0000647)	2.19536131
54	Lethargy (HP:0001254)	2.18256213
55	Medial flaring of the eyebrow (HP:0010747)	2.15764264
56	Pancytopenia (HP:0001876)	2.14798799
57	Leukodystrophy (HP:0002415)	2.12351705
58	Methylmalonic acidemia (HP:0002912)	2.12000936
59	Exercise intolerance (HP:0003546)	2.07116561
60	Respiratory difficulties (HP:0002880)	2.07030590
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05212642
62	Stenosis of the external auditory canal (HP:0000402)	2.04342647
63	Abnormality of the renal collecting system (HP:0004742)	2.03901239
64	Triphalangeal thumb (HP:0001199)	2.00208294
65	Abolished electroretinogram (ERG) (HP:0000550)	2.00152861
66	Methylmalonic aciduria (HP:0012120)	1.99382757
67	Hypoplasia of the radius (HP:0002984)	1.99067551
68	Exertional dyspnea (HP:0002875)	1.98899474
69	Retinal dysplasia (HP:0007973)	1.97084066
70	Abnormality of DNA repair (HP:0003254)	1.96499064
71	Abnormality of urine glucose concentration (HP:0011016)	1.95755242
72	Glycosuria (HP:0003076)	1.95755242
73	Horseshoe kidney (HP:0000085)	1.95641110
74	Abnormality of renal resorption (HP:0011038)	1.95157187
75	Increased muscle lipid content (HP:0009058)	1.89168244
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88811312
77	Rib fusion (HP:0000902)	1.86727764
78	Elevated erythrocyte sedimentation rate (HP:0003565)	1.86296011
79	Depressed nasal ridge (HP:0000457)	1.83917071
80	Anencephaly (HP:0002323)	1.82502150
81	Optic nerve coloboma (HP:0000588)	1.81892034
82	Congenital, generalized hypertrichosis (HP:0004540)	1.79935973
83	Partial duplication of thumb phalanx (HP:0009944)	1.76185597
84	Generalized aminoaciduria (HP:0002909)	1.74142009
85	Duplicated collecting system (HP:0000081)	1.70759302
86	X-linked dominant inheritance (HP:0001423)	1.69762171
87	Hyperthyroidism (HP:0000836)	1.69290386
88	Abnormality of the septum pellucidum (HP:0007375)	1.69058524
89	Abnormal number of incisors (HP:0011064)	1.68960746
90	Abnormality of the renal medulla (HP:0100957)	1.68949839
91	Cleft eyelid (HP:0000625)	1.68531190
92	Dicarboxylic aciduria (HP:0003215)	1.68366007
93	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.68366007
94	Gait imbalance (HP:0002141)	1.68128662
95	Retinitis pigmentosa (HP:0000510)	1.68090890
96	Small hand (HP:0200055)	1.67820455
97	Maternal diabetes (HP:0009800)	1.67446894
98	Congenital primary aphakia (HP:0007707)	1.67228171
99	Nephrogenic diabetes insipidus (HP:0009806)	1.66749549
100	Abnormality of magnesium homeostasis (HP:0004921)	1.66407386

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.06979328
2	CDK19	2.98183489
3	ZAK	2.71632480
4	GRK1	2.53649076
5	WNK4	2.42741263
6	ADRBK2	2.38766273
7	TLK1	2.36896625
8	BCKDK	2.36677241
9	DYRK2	2.27146749
10	VRK2	2.05279695
11	BMPR1B	2.02815118
12	KIT	1.98440468
13	CDC7	1.85740514
14	TAF1	1.77674745
15	PASK	1.74393051
16	NME2	1.72327564
17	VRK1	1.66981673
18	PINK1	1.65220506
19	TEC	1.64663896
20	TIE1	1.63078696
21	BUB1	1.61536248
22	MAP4K1	1.56604597
23	FES	1.54596701
24	TXK	1.50398039
25	NUAK1	1.49418956
26	MAP4K2	1.38183822
27	TYRO3	1.37237612
28	NME1	1.36590797
29	STK39	1.35924534
30	CDK8	1.34756492
31	LIMK1	1.33864330
32	MAP3K11	1.27004590
33	LRRK2	1.25191172
34	PBK	1.24405518
35	MAP3K12	1.23099688
36	KDR	1.20599172
37	NEK1	1.18661270
38	NEK2	1.17878925
39	WNK3	1.16888890
40	TESK2	1.11454258
41	PLK3	1.06606242
42	PDK2	1.02474815
43	PRKCG	1.00074668
44	MAP3K4	0.98649860
45	DYRK3	0.98446207
46	PLK1	0.97517836
47	OXSR1	0.94012800
48	CAMKK2	0.93373641
49	PIK3CA	0.92498955
50	TNIK	0.91940107
51	TRIM28	0.89286646
52	IKBKB	0.88885725
53	EIF2AK1	0.86224776
54	TAOK3	0.85391056
55	CSNK2A2	0.82792191
56	FRK	0.81205796
57	PLK4	0.78830615
58	ADRBK1	0.77454453
59	PRKCQ	0.76411497
60	AURKA	0.73654081
61	RPS6KA5	0.71071110
62	INSRR	0.69899206
63	AURKB	0.69627594
64	ABL2	0.68205985
65	EPHB2	0.63493274
66	CHEK2	0.62905167
67	CSNK1E	0.61375527
68	SYK	0.60498353
69	RPS6KB2	0.60230892
70	CSNK2A1	0.59459387
71	RPS6KA4	0.57957303
72	CAMK1	0.57779691
73	PRKACA	0.57016321
74	ATR	0.56965284
75	MAP2K7	0.56538927
76	PAK3	0.55998152
77	CSNK1G2	0.53153887
78	SIK2	0.51760284
79	ITK	0.51138860
80	PRKCI	0.50237990
81	TGFBR1	0.49653538
82	DAPK3	0.48563064
83	CSNK1G3	0.48368576
84	MST4	0.48171984
85	BTK	0.48017972
86	CSNK1G1	0.47134733
87	PIM1	0.46560605
88	SRPK1	0.44837044
89	NTRK2	0.41386420
90	STK4	0.40681287
91	CSNK1A1	0.40627009
92	PRKCA	0.39822663
93	INSR	0.38886281
94	MAPK15	0.36938565
95	MAP2K6	0.35880692
96	EPHA4	0.35774399
97	WEE1	0.35485465
98	DYRK1A	0.35082405
99	OBSCN	0.33654007
100	MUSK	0.33374838

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.87876439
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.63690739
3	Parkinsons disease_Homo sapiens_hsa05012	3.82816984
4	Proteasome_Homo sapiens_hsa03050	3.05681329
5	RNA polymerase_Homo sapiens_hsa03020	2.87354779
6	Huntingtons disease_Homo sapiens_hsa05016	2.70387585
7	Alzheimers disease_Homo sapiens_hsa05010	2.49652317
8	Protein export_Homo sapiens_hsa03060	2.36325912
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28524216
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.07315791
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80546576
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.72615946
13	RNA degradation_Homo sapiens_hsa03018	1.63879513
14	Phototransduction_Homo sapiens_hsa04744	1.59925234
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.59627708
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57256812
17	One carbon pool by folate_Homo sapiens_hsa00670	1.54809858
18	DNA replication_Homo sapiens_hsa03030	1.51982016
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51807790
20	Basal transcription factors_Homo sapiens_hsa03022	1.51335456
21	Homologous recombination_Homo sapiens_hsa03440	1.48080344
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45958453
23	Mismatch repair_Homo sapiens_hsa03430	1.36782126
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32638877
25	Folate biosynthesis_Homo sapiens_hsa00790	1.28072951
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27814862
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24854668
28	Base excision repair_Homo sapiens_hsa03410	1.21978429
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19255668
30	Purine metabolism_Homo sapiens_hsa00230	1.13389070
31	RNA transport_Homo sapiens_hsa03013	1.12534533
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11051910
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.11032280
34	Sulfur relay system_Homo sapiens_hsa04122	1.09611519
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.05717180
36	Spliceosome_Homo sapiens_hsa03040	1.05629768
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05003637
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.00969456
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93296327
40	Propanoate metabolism_Homo sapiens_hsa00640	0.92386782
41	Peroxisome_Homo sapiens_hsa04146	0.90244527
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.89929525
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87237341
44	Butanoate metabolism_Homo sapiens_hsa00650	0.87190339
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84307632
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83601157
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.82336856
48	Metabolic pathways_Homo sapiens_hsa01100	0.81077741
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.80258761
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79173904
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.78531537
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75325481
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73501560
54	Caffeine metabolism_Homo sapiens_hsa00232	0.72711525
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71572509
56	Sulfur metabolism_Homo sapiens_hsa00920	0.71022397
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70002295
58	Asthma_Homo sapiens_hsa05310	0.66211759
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.63677920
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.63243938
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62989544
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62283085
63	Olfactory transduction_Homo sapiens_hsa04740	0.62037010
64	Nicotine addiction_Homo sapiens_hsa05033	0.61543113
65	Fatty acid degradation_Homo sapiens_hsa00071	0.55209799
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51825359
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51661195
68	Allograft rejection_Homo sapiens_hsa05330	0.48413270
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46639263
70	Glutathione metabolism_Homo sapiens_hsa00480	0.45713631
71	Retinol metabolism_Homo sapiens_hsa00830	0.45298585
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43659502
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.43259043
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42906127
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42828961
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.42504701
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42135780
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41324860
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40384636
80	Fatty acid elongation_Homo sapiens_hsa00062	0.38490941
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36198541
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.35602337
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33588195
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33421128
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.33073836
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32883990
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30673835
88	Regulation of autophagy_Homo sapiens_hsa04140	0.29070281
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27929026
90	Taste transduction_Homo sapiens_hsa04742	0.27787369
91	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.25587367
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24981563
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.23983674
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.23469477
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21478601
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.18173249
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.17398107
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.16769718
99	Morphine addiction_Homo sapiens_hsa05032	0.16356848
100	Alcoholism_Homo sapiens_hsa05034	0.14830512

RPSAP61

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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