RPSAP63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.65568481
2viral transcription (GO:0019083)7.20763209
3translational termination (GO:0006415)6.88960618
4ribosomal small subunit biogenesis (GO:0042274)6.35633500
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.05830476
6cotranslational protein targeting to membrane (GO:0006613)5.97874029
7maturation of SSU-rRNA (GO:0030490)5.96408375
8protein targeting to ER (GO:0045047)5.95046005
9translational elongation (GO:0006414)5.93433002
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.69508053
11chaperone-mediated protein transport (GO:0072321)5.58018919
12protein localization to endoplasmic reticulum (GO:0070972)5.57195920
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.43228591
14ATP synthesis coupled proton transport (GO:0015986)5.43228591
15viral life cycle (GO:0019058)5.27350354
16cellular protein complex disassembly (GO:0043624)5.24273290
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.10255870
18establishment of protein localization to mitochondrial membrane (GO:0090151)5.07619524
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.04856381
20mitochondrial respiratory chain complex I assembly (GO:0032981)5.04856381
21NADH dehydrogenase complex assembly (GO:0010257)5.04856381
22DNA deamination (GO:0045006)5.02337132
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99180012
24protein complex biogenesis (GO:0070271)4.83121233
25translational initiation (GO:0006413)4.82111990
26ribosomal large subunit biogenesis (GO:0042273)4.69465757
27water-soluble vitamin biosynthetic process (GO:0042364)4.59431061
28protein complex disassembly (GO:0043241)4.43644042
29mitochondrial respiratory chain complex assembly (GO:0033108)4.39959352
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39225834
31behavioral response to nicotine (GO:0035095)4.27913491
32translation (GO:0006412)4.22588737
33preassembly of GPI anchor in ER membrane (GO:0016254)4.17748114
34macromolecular complex disassembly (GO:0032984)4.17410708
35electron transport chain (GO:0022900)3.97580068
36respiratory electron transport chain (GO:0022904)3.95239940
37protein neddylation (GO:0045116)3.94359262
38somite development (GO:0061053)3.85647661
39protein targeting to membrane (GO:0006612)3.85283982
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81194087
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78745712
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.77612584
43cellular component biogenesis (GO:0044085)3.77177232
44pseudouridine synthesis (GO:0001522)3.65645354
45ribonucleoprotein complex biogenesis (GO:0022613)3.61100073
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.60074753
47mRNA catabolic process (GO:0006402)3.58428113
48deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.51709388
49mannosylation (GO:0097502)3.45378876
50protein targeting to mitochondrion (GO:0006626)3.40657150
51exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34654650
52RNA catabolic process (GO:0006401)3.32544171
53establishment of protein localization to mitochondrion (GO:0072655)3.29253990
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.28280808
55termination of RNA polymerase III transcription (GO:0006386)3.28280808
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27869722
57chromatin remodeling at centromere (GO:0031055)3.27191867
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.23340439
59GTP biosynthetic process (GO:0006183)3.22658119
60pyrimidine nucleotide catabolic process (GO:0006244)3.22138133
61rRNA processing (GO:0006364)3.16178986
62rRNA metabolic process (GO:0016072)3.11556665
63cytidine metabolic process (GO:0046087)3.07883009
64cytidine catabolic process (GO:0006216)3.07883009
65cytidine deamination (GO:0009972)3.07883009
66protein localization to mitochondrion (GO:0070585)3.06570669
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05849801
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04553238
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03020514
70CENP-A containing nucleosome assembly (GO:0034080)3.02487560
71maturation of 5.8S rRNA (GO:0000460)3.01478544
72GPI anchor metabolic process (GO:0006505)2.97079459
73ATP biosynthetic process (GO:0006754)2.96819165
74hydrogen ion transmembrane transport (GO:1902600)2.91852551
75GPI anchor biosynthetic process (GO:0006506)2.91825497
76negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88899441
77positive regulation of protein homooligomerization (GO:0032464)2.85306831
78UTP biosynthetic process (GO:0006228)2.83252855
79kynurenine metabolic process (GO:0070189)2.82420291
80C-terminal protein lipidation (GO:0006501)2.77746894
81protein targeting (GO:0006605)2.73272166
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72473798
83kinetochore organization (GO:0051383)2.71502784
84C-terminal protein amino acid modification (GO:0018410)2.71490147
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70946200
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69898193
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68209668
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68209668
89positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.67536126
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65283554
91pyrimidine ribonucleoside catabolic process (GO:0046133)2.64022458
92establishment of protein localization to organelle (GO:0072594)2.62451997
93proton transport (GO:0015992)2.62288454
94protein deneddylation (GO:0000338)2.61704912
95UTP metabolic process (GO:0046051)2.61630013
96cytochrome complex assembly (GO:0017004)2.61492278
97rRNA modification (GO:0000154)2.60001445
98substrate-independent telencephalic tangential migration (GO:0021826)2.57045424
99substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.57045424
100hydrogen transport (GO:0006818)2.55244480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.86671796
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30910087
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.85705322
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.58452641
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.40303267
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26648409
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.16550128
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14757196
9VDR_22108803_ChIP-Seq_LS180_Human3.10563940
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00306350
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95550735
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.59816709
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57191435
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55008447
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51727764
16VDR_23849224_ChIP-Seq_CD4+_Human2.47675499
17ZNF274_21170338_ChIP-Seq_K562_Hela2.32384424
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24696885
19EZH2_22144423_ChIP-Seq_EOC_Human2.24523571
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17797688
21MYC_18940864_ChIP-ChIP_HL60_Human2.17358717
22ELK1_19687146_ChIP-ChIP_HELA_Human2.13353437
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10423725
24TTF2_22483619_ChIP-Seq_HELA_Human2.00630291
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99384373
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.99075332
27FOXP3_21729870_ChIP-Seq_TREG_Human1.96317896
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94804675
29XRN2_22483619_ChIP-Seq_HELA_Human1.94644260
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92817449
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87091188
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83984568
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83537061
34EWS_26573619_Chip-Seq_HEK293_Human1.81444675
35IRF1_19129219_ChIP-ChIP_H3396_Human1.78344907
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71132270
37IGF1R_20145208_ChIP-Seq_DFB_Human1.63650133
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60991913
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.57451798
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54295398
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52065356
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52019591
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.40946722
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40897387
45GABP_19822575_ChIP-Seq_HepG2_Human1.39482557
46TP53_22573176_ChIP-Seq_HFKS_Human1.38066902
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33073353
48DCP1A_22483619_ChIP-Seq_HELA_Human1.29119657
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28392163
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27849405
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22407222
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19458450
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18516151
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15901938
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13845569
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12471144
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12289886
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10030541
59KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09262059
60SOX2_19829295_ChIP-Seq_ESCs_Human1.09245043
61NANOG_19829295_ChIP-Seq_ESCs_Human1.09245043
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06519764
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04568986
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.03967594
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03926747
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03583891
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02884778
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.02790254
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02759307
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99964425
71FOXA1_25329375_ChIP-Seq_VCAP_Human0.99964425
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98684318
73RNF2_27304074_Chip-Seq_NSC_Mouse0.98101355
74CIITA_25753668_ChIP-Seq_RAJI_Human0.97165587
75AR_20517297_ChIP-Seq_VCAP_Human0.97104704
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95788155
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95604182
78NCOR_22424771_ChIP-Seq_293T_Human0.95104846
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95033277
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94983448
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94794089
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.94133403
83TAF2_19829295_ChIP-Seq_ESCs_Human0.93818515
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92962757
85CBP_20019798_ChIP-Seq_JUKART_Human0.92428209
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92428209
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91942971
88NANOG_20526341_ChIP-Seq_ESCs_Human0.90464626
89ERA_21632823_ChIP-Seq_H3396_Human0.90247266
90E2F7_22180533_ChIP-Seq_HELA_Human0.88299950
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87843612
92KDM5A_27292631_Chip-Seq_BREAST_Human0.86077772
93MYC_19829295_ChIP-Seq_ESCs_Human0.84305494
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.83352872
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.83341470
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82998323
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82829086
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81495892
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81076705
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81054655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.73651195
2MP0006292_abnormal_olfactory_placode4.18125044
3MP0008877_abnormal_DNA_methylation3.49853150
4MP0001986_abnormal_taste_sensitivity3.06809055
5MP0003646_muscle_fatigue2.60181857
6MP0001529_abnormal_vocalization2.43979889
7MP0003878_abnormal_ear_physiology2.42547601
8MP0005377_hearing/vestibular/ear_phenot2.42547601
9MP0002163_abnormal_gland_morphology2.37883156
10MP0005084_abnormal_gallbladder_morpholo2.20248295
11MP0002138_abnormal_hepatobiliary_system2.14137905
12MP0001485_abnormal_pinna_reflex2.12435558
13MP0005671_abnormal_response_to1.98429067
14MP0000372_irregular_coat_pigmentation1.91857385
15MP0004885_abnormal_endolymph1.91046332
16MP0006072_abnormal_retinal_apoptosis1.89035449
17MP0008872_abnormal_physiological_respon1.88494661
18MP0008789_abnormal_olfactory_epithelium1.87489427
19MP0001348_abnormal_lacrimal_gland1.85664987
20MP0004142_abnormal_muscle_tone1.83981438
21MP0002837_dystrophic_cardiac_calcinosis1.81812105
22MP0008875_abnormal_xenobiotic_pharmacok1.79597973
23MP0003718_maternal_effect1.66230357
24MP0003186_abnormal_redox_activity1.62784787
25MP0003787_abnormal_imprinting1.59583004
26MP0002876_abnormal_thyroid_physiology1.58984269
27MP0002277_abnormal_respiratory_mucosa1.56137805
28MP0003693_abnormal_embryo_hatching1.53465367
29MP0002938_white_spotting1.49598381
30MP0001905_abnormal_dopamine_level1.48710443
31MP0003315_abnormal_perineum_morphology1.47404197
32MP0004742_abnormal_vestibular_system1.46453823
33MP0005646_abnormal_pituitary_gland1.43862400
34MP0005389_reproductive_system_phenotype1.43577329
35MP0001293_anophthalmia1.41482646
36MP0001968_abnormal_touch/_nociception1.41212230
37MP0008058_abnormal_DNA_repair1.40397185
38MP0003786_premature_aging1.40150523
39MP0005187_abnormal_penis_morphology1.39024355
40MP0002160_abnormal_reproductive_system1.37886309
41MP0000049_abnormal_middle_ear1.35149320
42MP0000631_abnormal_neuroendocrine_gland1.32820959
43MP0008995_early_reproductive_senescence1.30647641
44MP0003806_abnormal_nucleotide_metabolis1.30554842
45MP0001919_abnormal_reproductive_system1.26886945
46MP0005379_endocrine/exocrine_gland_phen1.26359679
47MP0005551_abnormal_eye_electrophysiolog1.24413414
48MP0001873_stomach_inflammation1.24368742
49MP0004957_abnormal_blastocyst_morpholog1.23920917
50MP0003123_paternal_imprinting1.21544201
51MP0002102_abnormal_ear_morphology1.19736471
52MP0002736_abnormal_nociception_after1.19659672
53MP0003567_abnormal_fetal_cardiomyocyte1.19244604
54MP0002272_abnormal_nervous_system1.16600781
55MP0003136_yellow_coat_color1.16562516
56MP0009333_abnormal_splenocyte_physiolog1.16256615
57MP0003938_abnormal_ear_development1.15743643
58MP0002234_abnormal_pharynx_morphology1.13562040
59MP0002095_abnormal_skin_pigmentation1.11760444
60MP0004147_increased_porphyrin_level1.11442942
61MP0004145_abnormal_muscle_electrophysio1.11433364
62MP0005394_taste/olfaction_phenotype1.04793780
63MP0005499_abnormal_olfactory_system1.04793780
64MP0003122_maternal_imprinting1.03242227
65MP0003119_abnormal_digestive_system0.99588928
66MP0003121_genomic_imprinting0.98902541
67MP0005645_abnormal_hypothalamus_physiol0.96449478
68MP0000647_abnormal_sebaceous_gland0.96167568
69MP0005083_abnormal_biliary_tract0.95013972
70MP0002210_abnormal_sex_determination0.92421661
71MP0006035_abnormal_mitochondrial_morpho0.91670312
72MP0002184_abnormal_innervation0.91251150
73MP0000026_abnormal_inner_ear0.91245393
74MP0010094_abnormal_chromosome_stability0.89685807
75MP0006082_CNS_inflammation0.87328648
76MP0006036_abnormal_mitochondrial_physio0.86625099
77MP0001984_abnormal_olfaction0.82221895
78MP0001119_abnormal_female_reproductive0.82197977
79MP0006276_abnormal_autonomic_nervous0.81874120
80MP0003195_calcinosis0.81206178
81MP0009745_abnormal_behavioral_response0.80462549
82MP0003880_abnormal_central_pattern0.80081816
83MP0005636_abnormal_mineral_homeostasis0.79526326
84MP0001440_abnormal_grooming_behavior0.79150323
85MP0008932_abnormal_embryonic_tissue0.78196781
86MP0002751_abnormal_autonomic_nervous0.78039739
87MP0005253_abnormal_eye_physiology0.77715241
88MP0009053_abnormal_anal_canal0.77111065
89MP0000653_abnormal_sex_gland0.76936297
90MP0000537_abnormal_urethra_morphology0.76542613
91MP0002653_abnormal_ependyma_morphology0.75622292
92MP0003936_abnormal_reproductive_system0.75249726
93MP0001929_abnormal_gametogenesis0.74550976
94MP0001963_abnormal_hearing_physiology0.72582442
95MP0003937_abnormal_limbs/digits/tail_de0.71268494
96MP0000566_synostosis0.71054810
97MP0008007_abnormal_cellular_replicative0.68505914
98MP0001727_abnormal_embryo_implantation0.66347202
99MP0003698_abnormal_male_reproductive0.66197332
100MP0000778_abnormal_nervous_system0.65852763

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.78214650
2Abnormal mitochondria in muscle tissue (HP:0008316)5.05092704
3Acute encephalopathy (HP:0006846)4.78046043
4Progressive macrocephaly (HP:0004481)4.72585200
5Mitochondrial inheritance (HP:0001427)4.57009352
6Abnormality of cells of the erythroid lineage (HP:0012130)4.45457691
7Reticulocytopenia (HP:0001896)4.33777869
8Increased CSF lactate (HP:0002490)4.18322367
9Hepatocellular necrosis (HP:0001404)3.84575857
10Abnormal number of erythroid precursors (HP:0012131)3.83506197
11Cerebral edema (HP:0002181)3.76546383
12Macrocytic anemia (HP:0001972)3.69464916
13Hepatic necrosis (HP:0002605)3.55769750
14Increased hepatocellular lipid droplets (HP:0006565)3.52147981
15Hyperglycinemia (HP:0002154)3.47112138
16Pancreatic fibrosis (HP:0100732)3.30324132
17Pancreatic cysts (HP:0001737)3.21374238
18Abnormality of midbrain morphology (HP:0002418)3.16341039
19Molar tooth sign on MRI (HP:0002419)3.16341039
20Pallor (HP:0000980)3.09071730
213-Methylglutaconic aciduria (HP:0003535)3.08669478
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.00229321
23Lipid accumulation in hepatocytes (HP:0006561)2.99343765
24True hermaphroditism (HP:0010459)2.91614791
25Leukodystrophy (HP:0002415)2.91095220
26Congenital, generalized hypertrichosis (HP:0004540)2.86755853
27Exertional dyspnea (HP:0002875)2.82125125
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70369183
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70369183
30Renal Fanconi syndrome (HP:0001994)2.66249286
31Increased serum lactate (HP:0002151)2.65852604
32Exercise intolerance (HP:0003546)2.65515236
33Lactic acidosis (HP:0003128)2.64822713
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61664725
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57296870
36Methylmalonic acidemia (HP:0002912)2.56508981
37Abnormal hemoglobin (HP:0011902)2.46879398
38Optic disc pallor (HP:0000543)2.42172730
39Generalized aminoaciduria (HP:0002909)2.40660764
40Congenital stationary night blindness (HP:0007642)2.40406525
41Colon cancer (HP:0003003)2.39219769
42Abnormal rod and cone electroretinograms (HP:0008323)2.37175488
43Increased intramyocellular lipid droplets (HP:0012240)2.37074690
44Aplastic anemia (HP:0001915)2.30555168
45Respiratory failure (HP:0002878)2.29850986
46Nephronophthisis (HP:0000090)2.27339464
47Pancytopenia (HP:0001876)2.26028566
48Lethargy (HP:0001254)2.20455062
49Cystic liver disease (HP:0006706)2.20410183
50Pendular nystagmus (HP:0012043)2.16961527
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14851296
52Absent thumb (HP:0009777)2.10833771
53Sclerocornea (HP:0000647)2.07684018
54Concave nail (HP:0001598)2.06921756
55Type II lissencephaly (HP:0007260)2.06211408
56Elevated erythrocyte sedimentation rate (HP:0003565)2.04370253
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.03845877
58Porencephaly (HP:0002132)2.01506043
59Septo-optic dysplasia (HP:0100842)1.98309014
60Anencephaly (HP:0002323)1.96617178
61Methylmalonic aciduria (HP:0012120)1.95138516
62Abnormal number of incisors (HP:0011064)1.92894549
63Abnormality of B cell number (HP:0010975)1.92272060
64Abnormality of urine glucose concentration (HP:0011016)1.91172045
65Glycosuria (HP:0003076)1.91172045
66Cleft eyelid (HP:0000625)1.90511957
67Medial flaring of the eyebrow (HP:0010747)1.90402792
68Asplenia (HP:0001746)1.89672596
69Bilateral microphthalmos (HP:0007633)1.87131637
70Abnormality of the renal medulla (HP:0100957)1.85678983
71B lymphocytopenia (HP:0010976)1.85162672
72Large for gestational age (HP:0001520)1.85028793
73Triphalangeal thumb (HP:0001199)1.84098439
74Tubular atrophy (HP:0000092)1.82706985
75Increased muscle lipid content (HP:0009058)1.81267541
76Abnormal drinking behavior (HP:0030082)1.78029441
77Polydipsia (HP:0001959)1.78029441
78Postaxial foot polydactyly (HP:0001830)1.77453583
79Bile duct proliferation (HP:0001408)1.75799409
80Abnormal biliary tract physiology (HP:0012439)1.75799409
81Respiratory difficulties (HP:0002880)1.74928672
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.73398272
83Abnormality of renal resorption (HP:0011038)1.73214739
84Type 2 muscle fiber atrophy (HP:0003554)1.73028703
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72779528
86Hypothermia (HP:0002045)1.72547447
87Birth length less than 3rd percentile (HP:0003561)1.71029021
88Abolished electroretinogram (ERG) (HP:0000550)1.70717371
89Hypoplasia of the ulna (HP:0003022)1.70614258
90Abnormal respiratory motile cilium morphology (HP:0005938)1.69438619
91Abnormal respiratory epithelium morphology (HP:0012253)1.69438619
92Depressed nasal ridge (HP:0000457)1.68304959
93Abnormality of glycine metabolism (HP:0010895)1.66371516
94Abnormality of serine family amino acid metabolism (HP:0010894)1.66371516
95Hyperphosphaturia (HP:0003109)1.64937492
96Male pseudohermaphroditism (HP:0000037)1.64897847
97Intestinal atresia (HP:0011100)1.64561915
98Stenosis of the external auditory canal (HP:0000402)1.64558395
99Abnormality of the pons (HP:0007361)1.62983949
100Abnormality of the renal collecting system (HP:0004742)1.61430225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.19725007
2STK164.14969667
3TXK2.89146931
4TLK12.46894548
5ADRBK22.45695729
6NEK12.33069549
7NME22.31677480
8NUAK12.29603498
9TAOK32.23906717
10DYRK22.07176689
11ZAK2.01506970
12WNK41.98412014
13VRK21.92749183
14GRK11.81422531
15CDC71.80438548
16BUB11.70127664
17VRK11.63200797
18PASK1.59470043
19WNK31.57277958
20EIF2AK11.52647313
21PBK1.50357893
22TIE11.46977653
23INSRR1.37982824
24ABL21.26748880
25TRIM281.23763545
26MAP4K11.22219056
27PLK41.21749539
28MST41.17730627
29NME11.14142243
30PLK31.12234523
31GRK61.05397075
32STK391.01564123
33BCR1.00691833
34EPHB21.00392272
35RPS6KA50.95877527
36PIK3CA0.94814296
37KDR0.94424958
38PLK10.93825565
39OXSR10.93643021
40ATR0.89033939
41BMPR1B0.88833938
42MAP4K20.87785557
43TSSK60.87428035
44MAP3K120.85830598
45CSNK1G30.85241647
46TNIK0.83855071
47FRK0.82727647
48ITK0.82370029
49LRRK20.82102316
50AURKB0.80567224
51SRPK10.80415769
52PRKCQ0.79365295
53EIF2AK30.78614984
54CSNK1A1L0.78033739
55STK40.77298704
56EPHA30.76947280
57IKBKB0.76923671
58TEC0.76104964
59CSNK2A20.76010188
60CHEK20.74524789
61CSNK2A10.71979792
62MKNK20.71857511
63PDK20.71463283
64PRKCG0.69637670
65CSNK1G20.67498422
66PHKG10.67118708
67PHKG20.67118708
68EPHA40.66878633
69ADRBK10.66275761
70MKNK10.65530036
71CSNK1G10.61946041
72BRAF0.61421449
73DAPK20.61185535
74MAP3K90.61137502
75PINK10.60222730
76CLK10.58827580
77DYRK30.57897009
78PIM10.57697188
79KSR10.56877381
80MAPK150.56504127
81TTK0.54673079
82DAPK30.54403159
83CDK190.51841583
84CSNK1A10.51326592
85MAP3K110.51165055
86PRKACA0.48991171
87AURKA0.46542467
88WEE10.41018488
89STK30.40775643
90RPS6KA60.37854609
91TAF10.37527023
92PIM20.37217074
93LYN0.36543784
94TGFBR10.35583529
95OBSCN0.34645204
96MAPK130.34188200
97DYRK1B0.34082904
98RPS6KB20.33792450
99CDK80.33586802
100BTK0.32603232

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.94970350
2Oxidative phosphorylation_Homo sapiens_hsa001904.11834584
3Parkinsons disease_Homo sapiens_hsa050123.48610598
4Proteasome_Homo sapiens_hsa030503.19367061
5RNA polymerase_Homo sapiens_hsa030203.04981113
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75112115
7Huntingtons disease_Homo sapiens_hsa050162.40122187
8Protein export_Homo sapiens_hsa030602.28351096
9Asthma_Homo sapiens_hsa053102.28328981
10Alzheimers disease_Homo sapiens_hsa050102.21855304
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10033703
12DNA replication_Homo sapiens_hsa030302.04814190
13Mismatch repair_Homo sapiens_hsa034302.04462150
14Cardiac muscle contraction_Homo sapiens_hsa042601.88160477
15Basal transcription factors_Homo sapiens_hsa030221.86876186
16Autoimmune thyroid disease_Homo sapiens_hsa053201.83999768
17Allograft rejection_Homo sapiens_hsa053301.83675167
18Pyrimidine metabolism_Homo sapiens_hsa002401.83283506
19RNA degradation_Homo sapiens_hsa030181.75479077
20Homologous recombination_Homo sapiens_hsa034401.69852556
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66660141
22One carbon pool by folate_Homo sapiens_hsa006701.62968339
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39856962
24Linoleic acid metabolism_Homo sapiens_hsa005911.39795988
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.38219127
26Graft-versus-host disease_Homo sapiens_hsa053321.35517623
27Spliceosome_Homo sapiens_hsa030401.33525117
28Nucleotide excision repair_Homo sapiens_hsa034201.30997927
29Fanconi anemia pathway_Homo sapiens_hsa034601.29457955
30Nitrogen metabolism_Homo sapiens_hsa009101.18571159
31Base excision repair_Homo sapiens_hsa034101.18326616
32Collecting duct acid secretion_Homo sapiens_hsa049661.17225474
33Purine metabolism_Homo sapiens_hsa002301.16908428
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12481340
35Caffeine metabolism_Homo sapiens_hsa002321.12248950
36Type I diabetes mellitus_Homo sapiens_hsa049401.09004479
37Phototransduction_Homo sapiens_hsa047441.05114030
38Steroid biosynthesis_Homo sapiens_hsa001001.01867125
39RNA transport_Homo sapiens_hsa030130.99948212
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98676535
41Sulfur relay system_Homo sapiens_hsa041220.97479277
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92869218
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90519640
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90009310
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.86681666
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86494382
47Propanoate metabolism_Homo sapiens_hsa006400.85839946
48Primary immunodeficiency_Homo sapiens_hsa053400.84672685
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84657428
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83216165
51Sulfur metabolism_Homo sapiens_hsa009200.82678416
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80447120
53Rheumatoid arthritis_Homo sapiens_hsa053230.74866839
54Tryptophan metabolism_Homo sapiens_hsa003800.74708472
55Metabolic pathways_Homo sapiens_hsa011000.71610403
56Fat digestion and absorption_Homo sapiens_hsa049750.70481766
57Antigen processing and presentation_Homo sapiens_hsa046120.69568317
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68959345
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.66845138
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64993586
61Arachidonic acid metabolism_Homo sapiens_hsa005900.63823164
62Nicotine addiction_Homo sapiens_hsa050330.63036041
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.60422067
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59405197
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.58548130
66Olfactory transduction_Homo sapiens_hsa047400.56500062
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55911389
68Peroxisome_Homo sapiens_hsa041460.54915434
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53389359
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50196866
71Systemic lupus erythematosus_Homo sapiens_hsa053220.49857814
72Pyruvate metabolism_Homo sapiens_hsa006200.47962774
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47924401
74Chemical carcinogenesis_Homo sapiens_hsa052040.47796702
75Basal cell carcinoma_Homo sapiens_hsa052170.47701755
76Ether lipid metabolism_Homo sapiens_hsa005650.47310998
77p53 signaling pathway_Homo sapiens_hsa041150.44926260
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43710080
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41870044
80Epstein-Barr virus infection_Homo sapiens_hsa051690.41314684
81Hematopoietic cell lineage_Homo sapiens_hsa046400.40040680
82Glycerolipid metabolism_Homo sapiens_hsa005610.39226183
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38928729
84Glutathione metabolism_Homo sapiens_hsa004800.37005487
85Non-homologous end-joining_Homo sapiens_hsa034500.34790551
86Arginine and proline metabolism_Homo sapiens_hsa003300.31509084
87Butanoate metabolism_Homo sapiens_hsa006500.27945760
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26010341
89beta-Alanine metabolism_Homo sapiens_hsa004100.25565004
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25198544
91Fatty acid biosynthesis_Homo sapiens_hsa000610.24577868
92Cell cycle_Homo sapiens_hsa041100.24305984
93Ovarian steroidogenesis_Homo sapiens_hsa049130.24147062
94Morphine addiction_Homo sapiens_hsa050320.23812299
95Retinol metabolism_Homo sapiens_hsa008300.23466211
96Viral myocarditis_Homo sapiens_hsa054160.21440284
97Selenocompound metabolism_Homo sapiens_hsa004500.21316803
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20140170
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.12927235
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10679245

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