RPSAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.92960893
2viral transcription (GO:0019083)6.16473715
3DNA deamination (GO:0045006)6.00095133
4translational termination (GO:0006415)5.93115819
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.52710191
6ATP synthesis coupled proton transport (GO:0015986)5.52710191
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.33507319
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.28478982
9ribosomal small subunit biogenesis (GO:0042274)5.25142294
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.23013658
11translational elongation (GO:0006414)5.21155279
12cotranslational protein targeting to membrane (GO:0006613)5.14338877
13protein targeting to ER (GO:0045047)5.12331790
14maturation of SSU-rRNA (GO:0030490)5.11759138
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.07612735
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.90066158
17chaperone-mediated protein transport (GO:0072321)4.87371936
18protein localization to endoplasmic reticulum (GO:0070972)4.82291336
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79702627
20viral life cycle (GO:0019058)4.49630309
21cellular protein complex disassembly (GO:0043624)4.46851276
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40231197
23protein neddylation (GO:0045116)4.36986903
24ribosomal large subunit biogenesis (GO:0042273)4.35480771
25behavioral response to nicotine (GO:0035095)4.24548202
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.21750008
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.21750008
28NADH dehydrogenase complex assembly (GO:0010257)4.21750008
29protein complex biogenesis (GO:0070271)4.18780635
30respiratory electron transport chain (GO:0022904)4.13975591
31cytidine deamination (GO:0009972)4.12581597
32cytidine metabolic process (GO:0046087)4.12581597
33cytidine catabolic process (GO:0006216)4.12581597
34translational initiation (GO:0006413)4.12549349
35electron transport chain (GO:0022900)4.12059925
36mitochondrial respiratory chain complex assembly (GO:0033108)3.81315871
37translation (GO:0006412)3.80021173
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72417790
39protein complex disassembly (GO:0043241)3.71042136
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.68912802
41water-soluble vitamin biosynthetic process (GO:0042364)3.65866266
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56583099
43macromolecular complex disassembly (GO:0032984)3.54218618
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.43927471
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38640665
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38640665
47cellular component biogenesis (GO:0044085)3.33635581
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.31687832
49protein targeting to membrane (GO:0006612)3.31203492
50sequestering of actin monomers (GO:0042989)3.29635009
51response to pheromone (GO:0019236)3.25522256
52respiratory chain complex IV assembly (GO:0008535)3.22943144
53ubiquinone biosynthetic process (GO:0006744)3.19305658
54ribonucleoprotein complex biogenesis (GO:0022613)3.15226831
55mRNA catabolic process (GO:0006402)3.12993795
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09954157
57ATP biosynthetic process (GO:0006754)3.07388355
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.06644414
59proteasome assembly (GO:0043248)3.06578635
60intracellular protein transmembrane import (GO:0044743)3.05812636
61GTP biosynthetic process (GO:0006183)3.04288599
62cytochrome complex assembly (GO:0017004)3.00070190
63ncRNA 3-end processing (GO:0043628)2.98991126
64pyrimidine nucleotide catabolic process (GO:0006244)2.97482528
65termination of RNA polymerase III transcription (GO:0006386)2.95695711
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.95695711
67ubiquinone metabolic process (GO:0006743)2.93571075
68RNA catabolic process (GO:0006401)2.92750570
69chromatin remodeling at centromere (GO:0031055)2.91426972
70pseudouridine synthesis (GO:0001522)2.90421501
71preassembly of GPI anchor in ER membrane (GO:0016254)2.86274516
72hydrogen ion transmembrane transport (GO:1902600)2.85399047
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83680955
74platelet dense granule organization (GO:0060155)2.83385095
75rRNA processing (GO:0006364)2.83333060
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82699630
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79875645
78base-excision repair, AP site formation (GO:0006285)2.79806290
79rRNA metabolic process (GO:0016072)2.79158460
80regulation of cellular amino acid metabolic process (GO:0006521)2.78335182
81somite development (GO:0061053)2.76911171
82positive regulation of protein homodimerization activity (GO:0090073)2.72218190
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71158468
84deoxyribonucleotide catabolic process (GO:0009264)2.70250095
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69968744
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69926769
87quinone biosynthetic process (GO:1901663)2.69420470
88mannosylation (GO:0097502)2.68770581
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.68426384
90UTP metabolic process (GO:0046051)2.68099301
91deoxyribose phosphate catabolic process (GO:0046386)2.66827727
92CENP-A containing nucleosome assembly (GO:0034080)2.66777861
93UTP biosynthetic process (GO:0006228)2.66026826
94establishment of protein localization to mitochondrion (GO:0072655)2.64361207
95negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.62364314
96protein-cofactor linkage (GO:0018065)2.62116020
97proton transport (GO:0015992)2.61529883
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60976038
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60976038
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60976038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.37565995
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98916336
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.59402441
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40390605
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28477905
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16176631
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02779494
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.92101356
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89562090
10ZNF274_21170338_ChIP-Seq_K562_Hela2.85765323
11VDR_22108803_ChIP-Seq_LS180_Human2.64519685
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.53338772
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51724560
14VDR_23849224_ChIP-Seq_CD4+_Human2.45469221
15EZH2_22144423_ChIP-Seq_EOC_Human2.43784048
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41946766
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33622736
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.33136162
19ELK1_19687146_ChIP-ChIP_HELA_Human2.21913885
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.16479317
21FOXP3_21729870_ChIP-Seq_TREG_Human2.07430086
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94541536
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93986904
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85079537
25MYC_18940864_ChIP-ChIP_HL60_Human1.85059598
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84666001
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83873714
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.79086853
29IGF1R_20145208_ChIP-Seq_DFB_Human1.70836587
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69013966
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68397799
32EWS_26573619_Chip-Seq_HEK293_Human1.66754407
33IRF1_19129219_ChIP-ChIP_H3396_Human1.62436020
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.57150451
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56384052
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.53255099
37TTF2_22483619_ChIP-Seq_HELA_Human1.50852278
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40880908
39TP53_22573176_ChIP-Seq_HFKS_Human1.40294354
40XRN2_22483619_ChIP-Seq_HELA_Human1.38688848
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38302255
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37544079
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37344955
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34219200
45GABP_19822575_ChIP-Seq_HepG2_Human1.33100204
46FUS_26573619_Chip-Seq_HEK293_Human1.32420465
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30999154
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30758288
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.28926745
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28926745
51NANOG_20526341_ChIP-Seq_ESCs_Human1.25443126
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24153653
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23799516
54NCOR_22424771_ChIP-Seq_293T_Human1.22450962
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22349892
56AR_20517297_ChIP-Seq_VCAP_Human1.22113763
57CIITA_25753668_ChIP-Seq_RAJI_Human1.20114324
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19168804
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16930049
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16802583
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16513899
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16215594
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16025269
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12275546
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.12249377
66SOX2_19829295_ChIP-Seq_ESCs_Human1.11441196
67NANOG_19829295_ChIP-Seq_ESCs_Human1.11441196
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10622670
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08437600
70DCP1A_22483619_ChIP-Seq_HELA_Human1.07999170
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07491512
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07374015
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07213361
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05557221
75TAF2_19829295_ChIP-Seq_ESCs_Human1.05299751
76ERA_21632823_ChIP-Seq_H3396_Human1.04237307
77ERG_20517297_ChIP-Seq_VCAP_Human1.04177209
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04123072
79ER_23166858_ChIP-Seq_MCF-7_Human1.02463930
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00530141
81MYC_19829295_ChIP-Seq_ESCs_Human1.00173160
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98892102
83CBX2_27304074_Chip-Seq_ESCs_Mouse0.97801967
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97113272
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96671099
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.96144012
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95745680
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.94837580
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93967771
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92100975
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91343961
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90412445
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89831477
94P300_19829295_ChIP-Seq_ESCs_Human0.89204100
95TP63_19390658_ChIP-ChIP_HaCaT_Human0.89152285
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88993049
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88459204
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.88443704
99HOXB7_26014856_ChIP-Seq_BT474_Human0.88399220
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86387632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.38944548
2MP0006292_abnormal_olfactory_placode4.27160898
3MP0003878_abnormal_ear_physiology2.97583456
4MP0005377_hearing/vestibular/ear_phenot2.97583456
5MP0002837_dystrophic_cardiac_calcinosis2.70782138
6MP0005084_abnormal_gallbladder_morpholo2.63103064
7MP0008877_abnormal_DNA_methylation2.52042706
8MP0002138_abnormal_hepatobiliary_system2.48613986
9MP0002102_abnormal_ear_morphology2.42946283
10MP0005671_abnormal_response_to2.28150789
11MP0000372_irregular_coat_pigmentation2.09920693
12MP0003646_muscle_fatigue2.08346731
13MP0009333_abnormal_splenocyte_physiolog2.03003855
14MP0002653_abnormal_ependyma_morphology1.91174679
15MP0001485_abnormal_pinna_reflex1.87273879
16MP0008872_abnormal_physiological_respon1.82103973
17MP0005646_abnormal_pituitary_gland1.81444587
18MP0006072_abnormal_retinal_apoptosis1.79658841
19MP0004885_abnormal_endolymph1.75060675
20MP0003787_abnormal_imprinting1.60434190
21MP0005645_abnormal_hypothalamus_physiol1.59283495
22MP0003122_maternal_imprinting1.53871070
23MP0002638_abnormal_pupillary_reflex1.53013558
24MP0004142_abnormal_muscle_tone1.52989654
25MP0005551_abnormal_eye_electrophysiolog1.51533501
26MP0005075_abnormal_melanosome_morpholog1.50557019
27MP0001529_abnormal_vocalization1.45410709
28MP0001293_anophthalmia1.45322427
29MP0001968_abnormal_touch/_nociception1.44425994
30MP0004147_increased_porphyrin_level1.42005573
31MP0001873_stomach_inflammation1.35388096
32MP0002163_abnormal_gland_morphology1.34115604
33MP0003786_premature_aging1.33298574
34MP0000631_abnormal_neuroendocrine_gland1.31283387
35MP0003186_abnormal_redox_activity1.30190679
36MP0005389_reproductive_system_phenotype1.29980581
37MP0002160_abnormal_reproductive_system1.27792171
38MP0002938_white_spotting1.26425086
39MP0001764_abnormal_homeostasis1.25814920
40MP0002277_abnormal_respiratory_mucosa1.21725022
41MP0001986_abnormal_taste_sensitivity1.21463436
42MP0003718_maternal_effect1.19152446
43MP0008875_abnormal_xenobiotic_pharmacok1.19012587
44MP0001905_abnormal_dopamine_level1.18745318
45MP0000049_abnormal_middle_ear1.18499647
46MP0002876_abnormal_thyroid_physiology1.16267706
47MP0001835_abnormal_antigen_presentation1.16202086
48MP0001919_abnormal_reproductive_system1.15569013
49MP0002736_abnormal_nociception_after1.15110794
50MP0003567_abnormal_fetal_cardiomyocyte1.10829578
51MP0009785_altered_susceptibility_to1.08858463
52MP0004742_abnormal_vestibular_system1.08200558
53MP0008789_abnormal_olfactory_epithelium1.07630586
54MP0006276_abnormal_autonomic_nervous1.06121093
55MP0002234_abnormal_pharynx_morphology1.04475858
56MP0005253_abnormal_eye_physiology1.03116974
57MP0008995_early_reproductive_senescence1.02273207
58MP0008058_abnormal_DNA_repair1.02263169
59MP0002095_abnormal_skin_pigmentation1.00423533
60MP0002272_abnormal_nervous_system0.99634209
61MP0001188_hyperpigmentation0.98229324
62MP0003283_abnormal_digestive_organ0.96998687
63MP0004145_abnormal_muscle_electrophysio0.95779311
64MP0003880_abnormal_central_pattern0.94183224
65MP0002210_abnormal_sex_determination0.90743044
66MP0000685_abnormal_immune_system0.89761489
67MP0003011_delayed_dark_adaptation0.88719161
68MP0000026_abnormal_inner_ear0.88501099
69MP0001800_abnormal_humoral_immune0.87186642
70MP0002733_abnormal_thermal_nociception0.85984895
71MP0005379_endocrine/exocrine_gland_phen0.85877624
72MP0001970_abnormal_pain_threshold0.85753365
73MP0008775_abnormal_heart_ventricle0.84961899
74MP0006036_abnormal_mitochondrial_physio0.83005552
75MP0003121_genomic_imprinting0.82901211
76MP0005195_abnormal_posterior_eye0.80923685
77MP0002148_abnormal_hypersensitivity_rea0.77225127
78MP0001963_abnormal_hearing_physiology0.75818711
79MP0001929_abnormal_gametogenesis0.75779083
80MP0002006_tumorigenesis0.75392101
81MP0000653_abnormal_sex_gland0.74698471
82MP0003763_abnormal_thymus_physiology0.73420918
83MP0002752_abnormal_somatic_nervous0.73178223
84MP0005636_abnormal_mineral_homeostasis0.71599481
85MP0001145_abnormal_male_reproductive0.71109494
86MP0002166_altered_tumor_susceptibility0.69991331
87MP0009745_abnormal_behavioral_response0.69114835
88MP0001348_abnormal_lacrimal_gland0.68877007
89MP0008007_abnormal_cellular_replicative0.67619527
90MP0005387_immune_system_phenotype0.67239380
91MP0001790_abnormal_immune_system0.67239380
92MP0003937_abnormal_limbs/digits/tail_de0.67094892
93MP0003195_calcinosis0.66079431
94MP0000230_abnormal_systemic_arterial0.64815915
95MP0000613_abnormal_salivary_gland0.64309198
96MP0001119_abnormal_female_reproductive0.64280900
97MP0003136_yellow_coat_color0.64199248
98MP0001663_abnormal_digestive_system0.63893454
99MP0001440_abnormal_grooming_behavior0.62163967
100MP0006035_abnormal_mitochondrial_morpho0.61821666

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.82956585
2Mitochondrial inheritance (HP:0001427)4.58393621
3Reticulocytopenia (HP:0001896)4.27640339
4Abnormal mitochondria in muscle tissue (HP:0008316)4.21284841
5Acute encephalopathy (HP:0006846)4.21030254
6Increased CSF lactate (HP:0002490)4.11478790
7Progressive macrocephaly (HP:0004481)3.95289344
8Hepatocellular necrosis (HP:0001404)3.82339980
9Increased hepatocellular lipid droplets (HP:0006565)3.81644763
10Congenital stationary night blindness (HP:0007642)3.54838800
11Abnormality of cells of the erythroid lineage (HP:0012130)3.54107424
12Lipid accumulation in hepatocytes (HP:0006561)3.49468128
13Hepatic necrosis (HP:0002605)3.43555168
14Abnormality of midbrain morphology (HP:0002418)3.37401915
15Molar tooth sign on MRI (HP:0002419)3.37401915
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34286714
17Cerebral edema (HP:0002181)3.32961187
18Pancreatic fibrosis (HP:0100732)3.24763810
19Macrocytic anemia (HP:0001972)3.15589136
20Pancreatic cysts (HP:0001737)3.09857190
21Abnormal rod and cone electroretinograms (HP:0008323)3.04784647
22Renal Fanconi syndrome (HP:0001994)3.04160562
23Abnormal number of erythroid precursors (HP:0012131)3.02254014
24Colon cancer (HP:0003003)2.99638269
25True hermaphroditism (HP:0010459)2.93500781
263-Methylglutaconic aciduria (HP:0003535)2.89111453
27Increased intramyocellular lipid droplets (HP:0012240)2.78899409
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76190724
29Nephronophthisis (HP:0000090)2.69212139
30Optic disc pallor (HP:0000543)2.68617158
31Increased serum lactate (HP:0002151)2.67841404
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.65627309
33Elevated erythrocyte sedimentation rate (HP:0003565)2.63639488
34Asplenia (HP:0001746)2.59866693
35Lactic acidosis (HP:0003128)2.59681298
36Septo-optic dysplasia (HP:0100842)2.54373886
37Exertional dyspnea (HP:0002875)2.53756764
38Aplastic anemia (HP:0001915)2.49546157
39Hyperglycinemia (HP:0002154)2.47393459
40Pallor (HP:0000980)2.44514457
41Medial flaring of the eyebrow (HP:0010747)2.40630662
42Leukodystrophy (HP:0002415)2.34869584
43Lethargy (HP:0001254)2.33570581
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32893310
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32030112
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32030112
47Increased muscle lipid content (HP:0009058)2.31798941
48Respiratory failure (HP:0002878)2.31580647
49Abolished electroretinogram (ERG) (HP:0000550)2.29781021
50Methylmalonic acidemia (HP:0002912)2.28198899
51Absent thumb (HP:0009777)2.27528391
52Respiratory difficulties (HP:0002880)2.25261644
53Absent/shortened dynein arms (HP:0200106)2.17405754
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.17405754
55Abnormality of renal resorption (HP:0011038)2.15573067
56Partial duplication of thumb phalanx (HP:0009944)2.13683045
57Stenosis of the external auditory canal (HP:0000402)2.13564776
58Exercise intolerance (HP:0003546)2.10330597
59Sclerocornea (HP:0000647)2.10205395
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10051361
61Abnormality of the renal medulla (HP:0100957)2.07084798
62Decreased central vision (HP:0007663)2.05441726
63Hyperphosphaturia (HP:0003109)2.05409315
64Abnormality of urine glucose concentration (HP:0011016)2.05364736
65Glycosuria (HP:0003076)2.05364736
66Constricted visual fields (HP:0001133)2.04947509
67Pendular nystagmus (HP:0012043)2.03897087
68Abnormality of the renal cortex (HP:0011035)2.03364257
69Postaxial foot polydactyly (HP:0001830)1.98965462
70Abnormal respiratory motile cilium morphology (HP:0005938)1.98820124
71Abnormal respiratory epithelium morphology (HP:0012253)1.98820124
72Abnormality of B cell number (HP:0010975)1.94854294
73Congenital, generalized hypertrichosis (HP:0004540)1.94720158
74Methylmalonic aciduria (HP:0012120)1.94680568
75Cystic liver disease (HP:0006706)1.92431274
76Abnormal drinking behavior (HP:0030082)1.90822640
77Polydipsia (HP:0001959)1.90822640
78IgG deficiency (HP:0004315)1.90677388
79Partial duplication of the phalanx of hand (HP:0009999)1.87238742
80Pancytopenia (HP:0001876)1.86377227
81Type 2 muscle fiber atrophy (HP:0003554)1.86014437
82Triphalangeal thumb (HP:0001199)1.84917144
83Supernumerary spleens (HP:0009799)1.81438170
84Tubular atrophy (HP:0000092)1.79481084
85Congenital hepatic fibrosis (HP:0002612)1.78582228
86Optic nerve hypoplasia (HP:0000609)1.78309705
87Adrenal hypoplasia (HP:0000835)1.77518786
88Type I transferrin isoform profile (HP:0003642)1.77284017
89Abnormality of the labia minora (HP:0012880)1.76784598
90Congenital primary aphakia (HP:0007707)1.76163873
91Abnormal ciliary motility (HP:0012262)1.75583452
92Attenuation of retinal blood vessels (HP:0007843)1.74565404
93Type II lissencephaly (HP:0007260)1.73297777
94Abnormality of serine family amino acid metabolism (HP:0010894)1.72585849
95Abnormality of glycine metabolism (HP:0010895)1.72585849
96Gait imbalance (HP:0002141)1.72233503
97Muscle fiber atrophy (HP:0100295)1.71869034
98Increased IgM level (HP:0003496)1.71550213
99Anencephaly (HP:0002323)1.70643438
100Renal cortical cysts (HP:0000803)1.70519994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.82755896
2VRK23.61416623
3STK163.04029644
4NUAK12.53656751
5KDR2.47500228
6ADRBK22.42983993
7WNK42.40448343
8VRK12.38284845
9PASK2.35598556
10TXK2.26865942
11GRK12.26404797
12CDK192.20841963
13PINK12.15118408
14BMPR1B2.10729259
15ZAK2.08262055
16TLK11.94807213
17BUB11.91837256
18MAP4K21.83519357
19DYRK21.71064074
20TAOK31.61836688
21TESK21.54906594
22MAP4K11.39693402
23WNK31.37335055
24STK391.32421605
25PIK3CA1.26240618
26TIE11.26053524
27TAF11.24207765
28TRIM281.22723381
29CAMKK21.17754894
30FRK1.11170717
31NEK11.07578393
32TEC1.05251023
33ITK1.04531754
34LIMK11.04175807
35MAP3K120.99822000
36PLK30.96627834
37PRKCQ0.92370372
38GRK60.92349855
39OXSR10.91854214
40PLK40.91813552
41NME10.91783302
42CDC70.91131318
43MAP2K70.90215564
44TGFBR10.89581270
45MUSK0.88499520
46CDK80.84430584
47BCR0.82984414
48CSNK1G30.78366638
49AURKB0.78073059
50MKNK10.77005510
51MAP3K110.75635056
52CSNK1G20.72306130
53SYK0.71562039
54BTK0.71299181
55MKNK20.71298357
56DAPK30.71273767
57INSRR0.70399453
58NME20.68303662
59MAPK150.68159582
60CSNK1G10.67368950
61ATR0.66010733
62MAPK130.65981109
63CHEK20.65555336
64PLK10.62803027
65PRKCG0.62429794
66AURKA0.59264590
67CAMK10.58014407
68CAMKK10.57633768
69ERBB30.56731975
70CSNK2A10.56453767
71PLK20.56381080
72CSNK2A20.55949856
73SRPK10.55496244
74MAPKAPK30.55244403
75DAPK10.51468652
76MAP2K60.49710336
77PRKCE0.49636915
78RPS6KA50.49045968
79IKBKB0.48936537
80MST40.48788794
81KIT0.48772283
82MAPKAPK50.47908227
83MAP3K40.47550920
84PBK0.46693862
85RPS6KB20.46280491
86LCK0.46221096
87OBSCN0.45664981
88ACVR1B0.45202208
89PRKACA0.44523493
90ADRBK10.42763120
91TNK20.42622355
92NEK20.41234761
93EPHA40.40050416
94PRKCA0.39755744
95GRK50.36283755
96IGF1R0.35925413
97ILK0.34514815
98RPS6KA40.34330928
99TNIK0.34321774
100WEE10.34098975

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.26079289
2Oxidative phosphorylation_Homo sapiens_hsa001904.12270725
3Proteasome_Homo sapiens_hsa030503.72374553
4Parkinsons disease_Homo sapiens_hsa050123.44897708
5RNA polymerase_Homo sapiens_hsa030202.92060929
6Protein export_Homo sapiens_hsa030602.48458361
7Huntingtons disease_Homo sapiens_hsa050162.41232332
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33282916
9Alzheimers disease_Homo sapiens_hsa050102.22818919
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01068438
11Primary immunodeficiency_Homo sapiens_hsa053401.93165524
12Cardiac muscle contraction_Homo sapiens_hsa042601.88389613
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83562046
14Homologous recombination_Homo sapiens_hsa034401.80991083
15Pyrimidine metabolism_Homo sapiens_hsa002401.74688545
16Linoleic acid metabolism_Homo sapiens_hsa005911.72290164
17Asthma_Homo sapiens_hsa053101.66245984
18RNA degradation_Homo sapiens_hsa030181.64703720
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58193920
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57732891
21DNA replication_Homo sapiens_hsa030301.55021727
22Mismatch repair_Homo sapiens_hsa034301.48551450
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47980851
24Basal transcription factors_Homo sapiens_hsa030221.43259092
25Base excision repair_Homo sapiens_hsa034101.42967275
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36288699
27Fanconi anemia pathway_Homo sapiens_hsa034601.32944984
28Allograft rejection_Homo sapiens_hsa053301.32763970
29Phototransduction_Homo sapiens_hsa047441.31472109
30Autoimmune thyroid disease_Homo sapiens_hsa053201.28250005
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27831924
32Nucleotide excision repair_Homo sapiens_hsa034201.27744241
33Purine metabolism_Homo sapiens_hsa002301.26758222
34Caffeine metabolism_Homo sapiens_hsa002321.23256766
35Nitrogen metabolism_Homo sapiens_hsa009101.22470248
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.16155674
37Propanoate metabolism_Homo sapiens_hsa006401.15385373
38Peroxisome_Homo sapiens_hsa041461.15021092
39Spliceosome_Homo sapiens_hsa030401.11954205
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04682157
41Fat digestion and absorption_Homo sapiens_hsa049751.04644877
42Type I diabetes mellitus_Homo sapiens_hsa049401.02547563
43Graft-versus-host disease_Homo sapiens_hsa053321.00804508
44Butanoate metabolism_Homo sapiens_hsa006501.00726179
45RNA transport_Homo sapiens_hsa030130.99345796
46Steroid biosynthesis_Homo sapiens_hsa001000.97986362
47One carbon pool by folate_Homo sapiens_hsa006700.92835023
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90422140
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88183122
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87435496
51Antigen processing and presentation_Homo sapiens_hsa046120.83720836
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80198654
53Arachidonic acid metabolism_Homo sapiens_hsa005900.78358538
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.77075122
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75664294
56Metabolic pathways_Homo sapiens_hsa011000.74734735
57Tryptophan metabolism_Homo sapiens_hsa003800.74101434
58Chemical carcinogenesis_Homo sapiens_hsa052040.72109747
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.71180670
60Sulfur relay system_Homo sapiens_hsa041220.70057876
61Hematopoietic cell lineage_Homo sapiens_hsa046400.67848919
62Retinol metabolism_Homo sapiens_hsa008300.64558400
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62976580
64Olfactory transduction_Homo sapiens_hsa047400.61430855
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60540508
66Ether lipid metabolism_Homo sapiens_hsa005650.60410929
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56435283
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55912972
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54939822
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53555410
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.52196282
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51102097
73Pyruvate metabolism_Homo sapiens_hsa006200.50974511
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.49457221
75Folate biosynthesis_Homo sapiens_hsa007900.49246744
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48986243
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48945573
78Selenocompound metabolism_Homo sapiens_hsa004500.48226325
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46929866
80Vitamin digestion and absorption_Homo sapiens_hsa049770.44846036
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44510155
82Regulation of autophagy_Homo sapiens_hsa041400.44227339
83Systemic lupus erythematosus_Homo sapiens_hsa053220.44021746
84Fatty acid degradation_Homo sapiens_hsa000710.42585124
85Glutathione metabolism_Homo sapiens_hsa004800.42321794
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39963494
87Rheumatoid arthritis_Homo sapiens_hsa053230.38052433
88beta-Alanine metabolism_Homo sapiens_hsa004100.37193782
89Nicotine addiction_Homo sapiens_hsa050330.36492063
90Glycerolipid metabolism_Homo sapiens_hsa005610.33141479
91Collecting duct acid secretion_Homo sapiens_hsa049660.29317060
92T cell receptor signaling pathway_Homo sapiens_hsa046600.28284052
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.26520553
94Sulfur metabolism_Homo sapiens_hsa009200.25377544
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24443433
96Fatty acid elongation_Homo sapiens_hsa000620.23240277
97Morphine addiction_Homo sapiens_hsa050320.21259556
98Taste transduction_Homo sapiens_hsa047420.18466885
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17324898
100Epstein-Barr virus infection_Homo sapiens_hsa051690.15976502

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