ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.72573105
2	DNA deamination (GO:0045006)	5.26762662
3	viral transcription (GO:0019083)	4.76540002
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.67484111
5	cytidine metabolic process (GO:0046087)	4.63432420
6	cytidine catabolic process (GO:0006216)	4.63432420
7	cytidine deamination (GO:0009972)	4.63432420
8	translational termination (GO:0006415)	4.63325600
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.38576041
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.34573174
11	ATP synthesis coupled proton transport (GO:0015986)	4.34573174
12	GTP biosynthetic process (GO:0006183)	4.26093075
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.22730229
14	translational elongation (GO:0006414)	4.18656326
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.17723972
16	cotranslational protein targeting to membrane (GO:0006613)	4.10459089
17	protein targeting to ER (GO:0045047)	4.10280507
18	UTP biosynthetic process (GO:0006228)	4.06797273
19	ribosomal small subunit biogenesis (GO:0042274)	4.06502357
20	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.95078957
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.94737072
22	protein localization to endoplasmic reticulum (GO:0070972)	3.91458081
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.89683225
24	ncRNA 3-end processing (GO:0043628)	3.88969042
25	ribosomal large subunit biogenesis (GO:0042273)	3.74877302
26	UTP metabolic process (GO:0046051)	3.72674794
27	chaperone-mediated protein transport (GO:0072321)	3.64978390
28	translational initiation (GO:0006413)	3.62001593
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.61071395
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.61071395
31	proteasome assembly (GO:0043248)	3.59517720
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.58279257
33	viral life cycle (GO:0019058)	3.57521495
34	protein complex biogenesis (GO:0070271)	3.56125631
35	base-excision repair, AP site formation (GO:0006285)	3.55811753
36	rRNA modification (GO:0000154)	3.52538076
37	cellular protein complex disassembly (GO:0043624)	3.44209763
38	translation (GO:0006412)	3.42286135
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.39817000
40	NADH dehydrogenase complex assembly (GO:0010257)	3.39817000
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.39817000
42	CTP biosynthetic process (GO:0006241)	3.36390663
43	CTP metabolic process (GO:0046036)	3.36390663
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33707808
45	protein neddylation (GO:0045116)	3.32106933
46	response to pheromone (GO:0019236)	3.31110400
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.29227622
48	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.28504624
49	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.27438274
50	DNA double-strand break processing (GO:0000729)	3.26608944
51	pyrimidine nucleotide catabolic process (GO:0006244)	3.26421597
52	deoxyribose phosphate catabolic process (GO:0046386)	3.25851969
53	pseudouridine synthesis (GO:0001522)	3.24475273
54	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.20265936
55	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.20012503
56	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16657053
57	preassembly of GPI anchor in ER membrane (GO:0016254)	3.14693672
58	deoxyribonucleotide catabolic process (GO:0009264)	3.10755061
59	water-soluble vitamin biosynthetic process (GO:0042364)	3.10122429
60	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.09937715
61	electron transport chain (GO:0022900)	3.06880620
62	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.06472184
63	respiratory electron transport chain (GO:0022904)	3.04969297
64	maturation of SSU-rRNA (GO:0030490)	3.03526189
65	cellular component biogenesis (GO:0044085)	3.03412536
66	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.03355233
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.97804265
68	platelet dense granule organization (GO:0060155)	2.97491058
69	rRNA methylation (GO:0031167)	2.97233023
70	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.96589884
71	mannosylation (GO:0097502)	2.95134467
72	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.90350538
73	ribonucleoprotein complex biogenesis (GO:0022613)	2.89785865
74	guanosine-containing compound biosynthetic process (GO:1901070)	2.89528412
75	rRNA processing (GO:0006364)	2.89472877
76	protein complex disassembly (GO:0043241)	2.89232427
77	GPI anchor biosynthetic process (GO:0006506)	2.86924836
78	regulation of cellular amino acid metabolic process (GO:0006521)	2.86234955
79	rRNA metabolic process (GO:0016072)	2.84701027
80	formation of translation preinitiation complex (GO:0001731)	2.84028096
81	positive regulation of protein homodimerization activity (GO:0090073)	2.83278104
82	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.81636650
83	DNA catabolic process, exonucleolytic (GO:0000738)	2.81052906
84	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.79839023
85	macromolecular complex disassembly (GO:0032984)	2.79570894
86	nucleoside diphosphate phosphorylation (GO:0006165)	2.78648513
87	male meiosis I (GO:0007141)	2.77871963
88	regulation of isotype switching to IgG isotypes (GO:0048302)	2.76937644
89	regulation of immunoglobulin secretion (GO:0051023)	2.76678207
90	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.74812673
91	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.73615145
92	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.70759978
93	GPI anchor metabolic process (GO:0006505)	2.70652121
94	axonemal dynein complex assembly (GO:0070286)	2.69557210
95	termination of RNA polymerase III transcription (GO:0006386)	2.69137077
96	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69137077
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.69044150
98	response to interferon-beta (GO:0035456)	2.65783819
99	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.65453686
100	piRNA metabolic process (GO:0034587)	2.63583995

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.33726184
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.27435895
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.09747494
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.00300868
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28740985
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.16092283
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.03248640
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87517781
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.81001568
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.79742686
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.62279702
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59187692
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.52578705
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.45478614
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.42563259
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.40434221
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.30256832
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18023495
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.13151973
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.06638657
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.03770288
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03036057
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.01042377
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00229146
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96559907
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.87141389
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.83067569
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79367038
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.77696433
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.76627690
31	VDR_22108803_ChIP-Seq_LS180_Human	1.72765852
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71270948
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71065611
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.66621893
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65551832
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.61575762
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59053833
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56025437
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.55326327
40	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.55226807
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53575467
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.52980545
43	EWS_26573619_Chip-Seq_HEK293_Human	1.50070829
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49876303
45	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.49342792
46	CIITA_25753668_ChIP-Seq_RAJI_Human	1.44362941
47	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.42559135
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39066309
49	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38497773
50	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38497773
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37300227
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.35343105
53	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.35287857
54	MYB_26560356_Chip-Seq_TH2_Human	1.34204268
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.33213697
56	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31081380
57	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30792781
58	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29233904
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.28132283
60	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.27760158
61	XRN2_22483619_ChIP-Seq_HELA_Human	1.24936767
62	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23257524
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22121211
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19465923
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19357213
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17772193
67	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15413918
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13869549
69	GATA3_26560356_Chip-Seq_TH2_Human	1.12145161
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11467793
71	AR_20517297_ChIP-Seq_VCAP_Human	1.11117196
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.09314629
73	NCOR_22424771_ChIP-Seq_293T_Human	1.07410504
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07065995
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06842993
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04838767
77	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01954996
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01570115
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01570115
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.00464254
81	BCL6_27268052_Chip-Seq_Bcells_Human	0.99932351
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99267345
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98929790
84	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96462921
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96097275
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95195519
87	MYB_26560356_Chip-Seq_TH1_Human	0.94287702
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93524067
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.93461588
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92652473
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92131016
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90225344
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90015541
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89802450
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.88389403
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88324377
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.87036454
98	ERA_21632823_ChIP-Seq_H3396_Human	0.86874314
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84937119
100	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.84919633

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.04675838
2	MP0005671_abnormal_response_to	3.42231958
3	MP0001835_abnormal_antigen_presentation	3.33234467
4	MP0002138_abnormal_hepatobiliary_system	3.14975984
5	MP0009379_abnormal_foot_pigmentation	2.71541823
6	MP0005084_abnormal_gallbladder_morpholo	2.41383195
7	MP0009785_altered_susceptibility_to	2.29788423
8	MP0008877_abnormal_DNA_methylation	2.26452407
9	MP0009333_abnormal_splenocyte_physiolog	2.22166829
10	MP0002148_abnormal_hypersensitivity_rea	2.16084295
11	MP0002876_abnormal_thyroid_physiology	2.04865899
12	MP0001348_abnormal_lacrimal_gland	2.04743187
13	MP0002166_altered_tumor_susceptibility	1.97328004
14	MP0003786_premature_aging	1.91105564
15	MP0003646_muscle_fatigue	1.89860894
16	MP0008872_abnormal_physiological_respon	1.82867248
17	MP0003567_abnormal_fetal_cardiomyocyte	1.81052341
18	MP0002837_dystrophic_cardiac_calcinosis	1.80510324
19	MP0001873_stomach_inflammation	1.80306245
20	MP0008875_abnormal_xenobiotic_pharmacok	1.76662010
21	MP0001800_abnormal_humoral_immune	1.72755270
22	MP0000685_abnormal_immune_system	1.71433251
23	MP0005387_immune_system_phenotype	1.69978313
24	MP0001790_abnormal_immune_system	1.69978313
25	MP0002160_abnormal_reproductive_system	1.64742171
26	MP0002006_tumorigenesis	1.63357145
27	MP0002163_abnormal_gland_morphology	1.63320527
28	MP0003763_abnormal_thymus_physiology	1.60182705
29	MP0006072_abnormal_retinal_apoptosis	1.56763278
30	MP0003806_abnormal_nucleotide_metabolis	1.51719251
31	MP0001764_abnormal_homeostasis	1.48014630
32	MP0003186_abnormal_redox_activity	1.47252793
33	MP0003718_maternal_effect	1.46920952
34	MP0002653_abnormal_ependyma_morphology	1.45479402
35	MP0005389_reproductive_system_phenotype	1.43729484
36	MP0005000_abnormal_immune_tolerance	1.42253783
37	MP0005075_abnormal_melanosome_morpholog	1.41599602
38	MP0002723_abnormal_immune_serum	1.39071643
39	MP0005551_abnormal_eye_electrophysiolog	1.38482337
40	MP0005645_abnormal_hypothalamus_physiol	1.38023818
41	MP0001529_abnormal_vocalization	1.35441173
42	MP0000372_irregular_coat_pigmentation	1.34630582
43	MP0002398_abnormal_bone_marrow	1.34433934
44	MP0002420_abnormal_adaptive_immunity	1.33911777
45	MP0002102_abnormal_ear_morphology	1.31285066
46	MP0008789_abnormal_olfactory_epithelium	1.31247133
47	MP0001819_abnormal_immune_cell	1.28837607
48	MP0004147_increased_porphyrin_level	1.27773828
49	MP0008058_abnormal_DNA_repair	1.25562531
50	MP0006036_abnormal_mitochondrial_physio	1.25288750
51	MP0003866_abnormal_defecation	1.24430161
52	MP0000716_abnormal_immune_system	1.22335215
53	MP0004145_abnormal_muscle_electrophysio	1.20286946
54	MP0003787_abnormal_imprinting	1.19320680
55	MP0005025_abnormal_response_to	1.18202807
56	MP0005253_abnormal_eye_physiology	1.16597457
57	MP0010155_abnormal_intestine_physiology	1.16130173
58	MP0000689_abnormal_spleen_morphology	1.15585903
59	MP0001905_abnormal_dopamine_level	1.15458490
60	MP0002452_abnormal_antigen_presenting	1.12899810
61	MP0010094_abnormal_chromosome_stability	1.12707696
62	MP0005464_abnormal_platelet_physiology	1.12698724
63	MP0002132_abnormal_respiratory_system	1.11970196
64	MP0005379_endocrine/exocrine_gland_phen	1.09802473
65	MP0001293_anophthalmia	1.08666080
66	MP0002429_abnormal_blood_cell	1.08561560
67	MP0005083_abnormal_biliary_tract	1.08461366
68	MP0002822_catalepsy	1.05702208
69	MP0002722_abnormal_immune_system	1.03972908
70	MP0006035_abnormal_mitochondrial_morpho	1.03045433
71	MP0000703_abnormal_thymus_morphology	1.02237784
72	MP0001986_abnormal_taste_sensitivity	0.98532563
73	MP0004885_abnormal_endolymph	0.97474346
74	MP0005646_abnormal_pituitary_gland	0.96402817
75	MP0002095_abnormal_skin_pigmentation	0.95309536
76	MP0001919_abnormal_reproductive_system	0.93994027
77	MP0005377_hearing/vestibular/ear_phenot	0.93678481
78	MP0003878_abnormal_ear_physiology	0.93678481
79	MP0001929_abnormal_gametogenesis	0.92817737
80	MP0000490_abnormal_crypts_of	0.90554530
81	MP0004957_abnormal_blastocyst_morpholog	0.88973768
82	MP0001968_abnormal_touch/_nociception	0.87522936
83	MP0005410_abnormal_fertilization	0.86225274
84	MP0002210_abnormal_sex_determination	0.85649904
85	MP0008007_abnormal_cellular_replicative	0.84716984
86	MP0001845_abnormal_inflammatory_respons	0.82209696
87	MP0008469_abnormal_protein_level	0.82037726
88	MP0004134_abnormal_chest_morphology	0.79659027
89	MP0008995_early_reproductive_senescence	0.79606152
90	MP0005085_abnormal_gallbladder_physiolo	0.78426484
91	MP0009764_decreased_sensitivity_to	0.77337807
92	MP0001661_extended_life_span	0.77135984
93	MP0001765_abnormal_ion_homeostasis	0.76608989
94	MP0002693_abnormal_pancreas_physiology	0.73995049
95	MP0005636_abnormal_mineral_homeostasis	0.73519175
96	MP0000653_abnormal_sex_gland	0.72901542
97	MP0001664_abnormal_digestion	0.72307547
98	MP0001145_abnormal_male_reproductive	0.70834357
99	MP0001119_abnormal_female_reproductive	0.68614025
100	MP0001663_abnormal_digestive_system	0.67651554

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.16122532
2	Lipid accumulation in hepatocytes (HP:0006561)	3.93329052
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.86322351
4	Mitochondrial inheritance (HP:0001427)	3.85815533
5	Acute necrotizing encephalopathy (HP:0006965)	3.78396616
6	Increased CSF lactate (HP:0002490)	3.60837709
7	Renal Fanconi syndrome (HP:0001994)	3.45822554
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.45701018
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.45526988
10	B lymphocytopenia (HP:0010976)	3.41142283
11	Acute encephalopathy (HP:0006846)	3.32610995
12	Increased intramyocellular lipid droplets (HP:0012240)	3.32522112
13	Hepatic necrosis (HP:0002605)	3.29803204
14	Hepatocellular necrosis (HP:0001404)	3.29629917
15	Abnormality of B cell number (HP:0010975)	3.28427347
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.21598518
17	3-Methylglutaconic aciduria (HP:0003535)	3.12253217
18	Congenital stationary night blindness (HP:0007642)	3.11292098
19	Aplastic anemia (HP:0001915)	3.10452730
20	Progressive macrocephaly (HP:0004481)	3.08920339
21	Abnormal rod and cone electroretinograms (HP:0008323)	3.06775736
22	Abnormality of midbrain morphology (HP:0002418)	3.02669287
23	Molar tooth sign on MRI (HP:0002419)	3.02669287
24	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.02298436
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.01913038
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.01913038
27	Reticulocytopenia (HP:0001896)	3.00789622
28	Asplenia (HP:0001746)	2.93948064
29	Severe combined immunodeficiency (HP:0004430)	2.93392549
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.88408973
31	IgG deficiency (HP:0004315)	2.87489472
32	Increased muscle lipid content (HP:0009058)	2.86062306
33	Exertional dyspnea (HP:0002875)	2.85485722
34	Cerebral edema (HP:0002181)	2.79483429
35	Absent/shortened dynein arms (HP:0200106)	2.79102839
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.79102839
37	Nephronophthisis (HP:0000090)	2.73479312
38	Increased serum lactate (HP:0002151)	2.71920585
39	Abnormal ciliary motility (HP:0012262)	2.67469944
40	Pancreatic fibrosis (HP:0100732)	2.66646714
41	Panhypogammaglobulinemia (HP:0003139)	2.63783789
42	Constricted visual fields (HP:0001133)	2.63224269
43	Respiratory difficulties (HP:0002880)	2.61141658
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.59930787
45	Glycosuria (HP:0003076)	2.59805959
46	Abnormality of urine glucose concentration (HP:0011016)	2.59805959
47	Abnormality of macular pigmentation (HP:0008002)	2.57202203
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.56658797
49	Abnormal respiratory epithelium morphology (HP:0012253)	2.56658797
50	T lymphocytopenia (HP:0005403)	2.55683676
51	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55010208
52	Thyroiditis (HP:0100646)	2.54973530
53	Pancreatic cysts (HP:0001737)	2.53639215
54	Hypoproteinemia (HP:0003075)	2.46016796
55	Chronic sinusitis (HP:0011109)	2.45009020
56	Abolished electroretinogram (ERG) (HP:0000550)	2.44038379
57	True hermaphroditism (HP:0010459)	2.43537241
58	Optic disc pallor (HP:0000543)	2.42025673
59	Lactic acidosis (HP:0003128)	2.39499537
60	Combined immunodeficiency (HP:0005387)	2.36281079
61	Abnormality of T cell number (HP:0011839)	2.33890968
62	Stomatitis (HP:0010280)	2.31637864
63	Increased IgM level (HP:0003496)	2.31466121
64	Pancytopenia (HP:0001876)	2.23772476
65	Exercise intolerance (HP:0003546)	2.21271056
66	Macrocytic anemia (HP:0001972)	2.17828705
67	Abnormality of renal resorption (HP:0011038)	2.16908449
68	Hypoplasia of the uterus (HP:0000013)	2.15264011
69	Central scotoma (HP:0000603)	2.11638319
70	Generalized aminoaciduria (HP:0002909)	2.10176911
71	Attenuation of retinal blood vessels (HP:0007843)	2.08566751
72	Abnormality of T cells (HP:0002843)	2.07642040
73	Decreased central vision (HP:0007663)	2.05803393
74	Abnormal number of erythroid precursors (HP:0012131)	2.03924898
75	Hyperglycinemia (HP:0002154)	2.03822115
76	Medial flaring of the eyebrow (HP:0010747)	2.02167788
77	Pallor (HP:0000980)	2.01170326
78	Abnormality of the renal medulla (HP:0100957)	2.00228554
79	Microvesicular hepatic steatosis (HP:0001414)	1.99974840
80	Retinal dysplasia (HP:0007973)	1.97232993
81	Abnormal biliary tract physiology (HP:0012439)	1.97141887
82	Bile duct proliferation (HP:0001408)	1.97141887
83	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.97128010
84	Agammaglobulinemia (HP:0004432)	1.94557009
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.93697228
86	Reduced antithrombin III activity (HP:0001976)	1.92162358
87	Ketosis (HP:0001946)	1.91834895
88	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.91210037
89	Lethargy (HP:0001254)	1.90640537
90	Abnormal protein glycosylation (HP:0012346)	1.88973897
91	Abnormal glycosylation (HP:0012345)	1.88973897
92	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88973897
93	Abnormal protein N-linked glycosylation (HP:0012347)	1.88973897
94	Thrombocytosis (HP:0001894)	1.87299858
95	Respiratory failure (HP:0002878)	1.87061149
96	Colon cancer (HP:0003003)	1.86236741
97	Autoimmune hemolytic anemia (HP:0001890)	1.85189631
98	Dicarboxylic aciduria (HP:0003215)	1.85168132
99	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.85168132
100	Hypoplasia of the thymus (HP:0000778)	1.84357199

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.71045909
2	CDK19	3.15998729
3	PBK	3.14107590
4	TESK2	3.11433006
5	VRK2	2.92304162
6	GRK1	2.77888622
7	TAOK3	2.60378797
8	TXK	2.59177143
9	BCKDK	2.57863838
10	MAP3K12	2.49167762
11	ADRBK2	2.48788374
12	BMPR1B	2.09729141
13	TAF1	2.03738555
14	KDR	1.99678377
15	MAP4K2	1.93285522
16	VRK1	1.90822271
17	MAP4K1	1.90267399
18	MST4	1.83527840
19	FRK	1.79136599
20	ZAK	1.76179925
21	TLK1	1.71814633
22	DAPK1	1.68764344
23	CDC7	1.51182163
24	NUAK1	1.50890755
25	WNK4	1.42085827
26	EIF2AK3	1.29774795
27	SCYL2	1.29400709
28	MAP2K6	1.27111539
29	PASK	1.24825445
30	CDK8	1.14172952
31	TGFBR1	1.07721050
32	EIF2AK1	1.06975946
33	DAPK2	1.06399527
34	DAPK3	1.05706130
35	TEC	1.04800200
36	PINK1	1.01930756
37	KIT	0.99907483
38	DYRK2	0.99766867
39	ITK	0.99676196
40	PRKCQ	0.99424123
41	PLK3	0.95509310
42	PLK4	0.90966182
43	CSF1R	0.89263177
44	NME2	0.87733958
45	IKBKB	0.85238410
46	BRSK2	0.84852347
47	NME1	0.84351593
48	PRKG2	0.82932306
49	MYLK	0.81373469
50	BUB1	0.81344992
51	MARK3	0.78792556
52	TRIM28	0.77615076
53	SYK	0.77284682
54	FLT3	0.76892547
55	TIE1	0.69837934
56	PLK1	0.66867926
57	NEK1	0.66860237
58	RPS6KA6	0.66002343
59	RPS6KB1	0.65644335
60	BMPR2	0.64407739
61	RPS6KB2	0.63388733
62	OXSR1	0.63139322
63	PIK3CG	0.61127363
64	ILK	0.61115681
65	BTK	0.60432212
66	INSRR	0.60164929
67	ATR	0.59606977
68	RPS6KC1	0.59210618
69	RPS6KL1	0.59210618
70	STK39	0.56845411
71	ACVR1B	0.56842625
72	MUSK	0.56619783
73	NEK2	0.55122867
74	MAP3K11	0.54714101
75	ADRBK1	0.54552571
76	WEE1	0.53543350
77	LCK	0.53371804
78	MAP3K5	0.52707753
79	PIK3CA	0.52395558
80	MATK	0.51843947
81	PRKCH	0.51055968
82	PLK2	0.48952932
83	MAP2K7	0.47889904
84	AURKA	0.46578292
85	LYN	0.44804893
86	CSNK2A2	0.44070407
87	PRKCD	0.43724316
88	CHEK2	0.42846537
89	CSNK2A1	0.42269905
90	CDK9	0.41227461
91	AURKB	0.40600319
92	MAPKAPK5	0.39979984
93	MAP3K4	0.38538086
94	MKNK1	0.38467901
95	PIM1	0.38293924
96	TBK1	0.37792017
97	SIK3	0.36491623
98	RPS6KA5	0.34897134
99	PIM2	0.33388380
100	CDK7	0.31875910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.58332488
2	Proteasome_Homo sapiens_hsa03050	3.85680238
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10902705
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.98361509
5	Parkinsons disease_Homo sapiens_hsa05012	2.75618283
6	Asthma_Homo sapiens_hsa05310	2.42573669
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42247361
8	Allograft rejection_Homo sapiens_hsa05330	2.36829844
9	RNA polymerase_Homo sapiens_hsa03020	2.25787363
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.21901374
11	Protein export_Homo sapiens_hsa03060	2.21493783
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.07342453
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.91885466
14	DNA replication_Homo sapiens_hsa03030	1.88506191
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.85847886
16	Homologous recombination_Homo sapiens_hsa03440	1.85723213
17	Huntingtons disease_Homo sapiens_hsa05016	1.84689786
18	Basal transcription factors_Homo sapiens_hsa03022	1.77979205
19	Base excision repair_Homo sapiens_hsa03410	1.74267234
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.74208537
21	RNA degradation_Homo sapiens_hsa03018	1.70658016
22	Propanoate metabolism_Homo sapiens_hsa00640	1.58108497
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54937278
24	Alzheimers disease_Homo sapiens_hsa05010	1.54067422
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50394110
26	Phototransduction_Homo sapiens_hsa04744	1.47477943
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41553450
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.40219963
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38390221
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34963518
31	Caffeine metabolism_Homo sapiens_hsa00232	1.32223627
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30106376
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.29995253
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29045935
35	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28505299
36	Peroxisome_Homo sapiens_hsa04146	1.27263597
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26733751
38	Mismatch repair_Homo sapiens_hsa03430	1.25784411
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19160555
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.14985331
41	Purine metabolism_Homo sapiens_hsa00230	1.12602850
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.12487640
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09961889
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.08940370
45	RNA transport_Homo sapiens_hsa03013	1.08039999
46	Butanoate metabolism_Homo sapiens_hsa00650	1.02107445
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00735065
48	Fatty acid elongation_Homo sapiens_hsa00062	0.99414114
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96454808
50	Spliceosome_Homo sapiens_hsa03040	0.92964534
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.91331756
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87860733
53	One carbon pool by folate_Homo sapiens_hsa00670	0.84333186
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81716688
55	Olfactory transduction_Homo sapiens_hsa04740	0.81198897
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80293768
57	Retinol metabolism_Homo sapiens_hsa00830	0.75579859
58	Metabolic pathways_Homo sapiens_hsa01100	0.72362213
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71442100
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69143532
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68302769
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68233643
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.66507155
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65974783
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.62103973
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60367283
67	Glutathione metabolism_Homo sapiens_hsa00480	0.60340801
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59386669
69	Fatty acid degradation_Homo sapiens_hsa00071	0.56412195
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54884506
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53996592
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.53374854
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.51997288
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51808383
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51613347
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51296665
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48294566
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48006909
79	Sulfur metabolism_Homo sapiens_hsa00920	0.46863003
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46342780
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45286005
82	Regulation of autophagy_Homo sapiens_hsa04140	0.45037418
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44528401
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43850541
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42993016
86	p53 signaling pathway_Homo sapiens_hsa04115	0.38616761
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38313626
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37683944
89	Herpes simplex infection_Homo sapiens_hsa05168	0.37521187
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.34131755
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.32986725
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32820018
93	Measles_Homo sapiens_hsa05162	0.32068336
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30702691
95	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.29463751
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27902383
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27167742
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26914430
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.26599693
100	Sulfur relay system_Homo sapiens_hsa04122	0.26125761

RPSAP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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