RPTOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.44696106
2embryonic process involved in female pregnancy (GO:0060136)6.45218833
3regulation of integrin activation (GO:0033623)6.17247689
4proline metabolic process (GO:0006560)6.09411206
5transcription from mitochondrial promoter (GO:0006390)6.05032048
6positive regulation of protein homooligomerization (GO:0032464)5.93285534
7regulation of protein homooligomerization (GO:0032462)5.56891445
8establishment of apical/basal cell polarity (GO:0035089)5.35453519
9replication fork processing (GO:0031297)5.28953516
10oxidative demethylation (GO:0070989)5.14762582
11regulation of translational fidelity (GO:0006450)4.73898947
12embryonic placenta development (GO:0001892)4.68180773
13establishment or maintenance of monopolar cell polarity (GO:0061339)4.64591862
14establishment of monopolar cell polarity (GO:0061162)4.64591862
15negative regulation of protein oligomerization (GO:0032460)4.53703796
16mitotic G1 DNA damage checkpoint (GO:0031571)4.41784463
17mitochondrial DNA metabolic process (GO:0032042)4.25516231
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.23163812
19negative regulation of Ras GTPase activity (GO:0034261)4.21205355
20spliceosomal tri-snRNP complex assembly (GO:0000244)4.12700796
21mRNA cleavage (GO:0006379)4.07636095
22DNA strand renaturation (GO:0000733)4.05106151
23pre-miRNA processing (GO:0031054)3.90113723
24G1 DNA damage checkpoint (GO:0044783)3.89671934
25negative regulation of erythrocyte differentiation (GO:0045647)3.89272715
26adherens junction assembly (GO:0034333)3.88334418
27regulation of protein oligomerization (GO:0032459)3.84701265
28signal complex assembly (GO:0007172)3.83311928
29mitotic G1/S transition checkpoint (GO:0044819)3.83263177
30glutamine family amino acid biosynthetic process (GO:0009084)3.81414451
31negative regulation of JAK-STAT cascade (GO:0046426)3.80035720
32mannose metabolic process (GO:0006013)3.79641479
33apoptotic process involved in morphogenesis (GO:0060561)3.76192801
34cell-substrate adherens junction assembly (GO:0007045)3.76120072
35focal adhesion assembly (GO:0048041)3.76120072
36negative regulation of fatty acid biosynthetic process (GO:0045717)3.71112211
37protein localization to endosome (GO:0036010)3.70614345
38poly(A)+ mRNA export from nucleus (GO:0016973)3.65988013
39positive regulation by host of viral transcription (GO:0043923)3.62334399
40positive regulation of protein oligomerization (GO:0032461)3.62081186
41cellular response to ATP (GO:0071318)3.61945843
42histone H4-K12 acetylation (GO:0043983)3.54685363
43regulation of RNA export from nucleus (GO:0046831)3.54394685
44embryonic camera-type eye development (GO:0031076)3.48829239
45dosage compensation (GO:0007549)3.48274279
46convergent extension (GO:0060026)3.47628942
47activation of Rac GTPase activity (GO:0032863)3.46302895
48cell-substrate junction assembly (GO:0007044)3.44893866
49glucocorticoid receptor signaling pathway (GO:0042921)3.43834507
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41233064
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.41233064
52cytoskeletal anchoring at plasma membrane (GO:0007016)3.39454493
53negative regulation of cell size (GO:0045792)3.38310709
54synaptic vesicle endocytosis (GO:0048488)3.38268567
55regulation of protein polyubiquitination (GO:1902914)3.36747242
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31440090
57labyrinthine layer development (GO:0060711)3.26534964
58regulation of NFAT protein import into nucleus (GO:0051532)3.23136081
59cellular response to zinc ion (GO:0071294)3.22944841
60glial cell migration (GO:0008347)3.22684064
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22562493
62negative regulation of cell cycle arrest (GO:0071157)3.18873649
63response to laminar fluid shear stress (GO:0034616)3.18394200
64carnitine shuttle (GO:0006853)3.13289059
65nuclear pore complex assembly (GO:0051292)3.13154538
66anatomical structure regression (GO:0060033)3.12319945
67regulation of cAMP-dependent protein kinase activity (GO:2000479)3.09721583
68regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.09124989
69determination of adult lifespan (GO:0008340)3.08687570
70low-density lipoprotein particle clearance (GO:0034383)3.07468616
71trophectodermal cell differentiation (GO:0001829)3.07394259
72nodal signaling pathway (GO:0038092)3.03584014
73cell migration in hindbrain (GO:0021535)3.02373783
74corticosteroid receptor signaling pathway (GO:0031958)3.01798440
75intracellular estrogen receptor signaling pathway (GO:0030520)3.01309994
76regulation of early endosome to late endosome transport (GO:2000641)3.00821029
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99829146
78regulation of posttranscriptional gene silencing (GO:0060147)2.98211318
79regulation of gene silencing by miRNA (GO:0060964)2.98211318
80regulation of gene silencing by RNA (GO:0060966)2.98211318
81regulation of hippo signaling (GO:0035330)2.95459711
82face development (GO:0060324)2.95254127
83stress fiber assembly (GO:0043149)2.94002824
84regulation of nucleobase-containing compound transport (GO:0032239)2.92995317
85protein targeting to lysosome (GO:0006622)2.92617144
86establishment of protein localization to vacuole (GO:0072666)2.92617144
87protein targeting to vacuole (GO:0006623)2.92617144
88positive regulation of developmental pigmentation (GO:0048087)2.91817692
89mitotic chromosome condensation (GO:0007076)2.90789514
90base-excision repair (GO:0006284)2.90119329
91regulation of histone H3-K27 methylation (GO:0061085)2.88899994
92pinocytosis (GO:0006907)2.87727958
93DNA demethylation (GO:0080111)2.87322201
94regulation of sister chromatid cohesion (GO:0007063)2.87130509
95regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.83976700
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83307194
97regulation of ARF GTPase activity (GO:0032312)2.82133426
98positive regulation of myotube differentiation (GO:0010831)2.81989111
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.81940376
100neural tube closure (GO:0001843)2.81402904
101apoptotic process involved in development (GO:1902742)2.81401104
102basement membrane organization (GO:0071711)2.81309299
103glycogen catabolic process (GO:0005980)2.80662641
104negative regulation of fatty acid transport (GO:2000192)2.77232209
105DNA deamination (GO:0045006)2.77222009
106negative regulation of mRNA processing (GO:0050686)2.75731084
107tube closure (GO:0060606)2.75026297
108modulation by symbiont of host cellular process (GO:0044068)2.74938647
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74675079
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74675079
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.74675079
112sulfur amino acid catabolic process (GO:0000098)2.74607504
113fatty acid transmembrane transport (GO:1902001)2.74165229
114histone H3-K36 demethylation (GO:0070544)2.73264345
115negative regulation of viral release from host cell (GO:1902187)2.72642821
116cellular protein complex localization (GO:0034629)2.72642590
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.71083108
118negative regulation of glial cell proliferation (GO:0060253)2.69567799
119neuromuscular process controlling posture (GO:0050884)2.69548652
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68999897
121anterior/posterior axis specification, embryo (GO:0008595)2.68843235
122positive regulation of receptor recycling (GO:0001921)2.68738987
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.68466255
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67401589
125activation of MAPKKK activity (GO:0000185)2.66066154
126negative regulation of chondrocyte differentiation (GO:0032331)2.64919137
127negative regulation of myotube differentiation (GO:0010832)2.64870202
128positive regulation of histone deacetylation (GO:0031065)2.63222409
129hemidesmosome assembly (GO:0031581)2.62788091
130regulation of cholesterol homeostasis (GO:2000188)2.62426915
131glucan catabolic process (GO:0009251)2.62192311
132N-glycan processing (GO:0006491)2.61475222
133regulation of DNA damage checkpoint (GO:2000001)2.61107031
134semaphorin-plexin signaling pathway (GO:0071526)2.60675185
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59964165
136peptidyl-lysine dimethylation (GO:0018027)2.51704070
137Golgi transport vesicle coating (GO:0048200)2.47445171
138COPI coating of Golgi vesicle (GO:0048205)2.47445171
139pore complex assembly (GO:0046931)2.47235496
140receptor catabolic process (GO:0032801)2.46955930
141endothelial cell chemotaxis (GO:0035767)2.45601791
142barbed-end actin filament capping (GO:0051016)2.44926573
143cortical actin cytoskeleton organization (GO:0030866)2.43003071
144response to muramyl dipeptide (GO:0032495)2.42577667
1453-UTR-mediated mRNA stabilization (GO:0070935)2.40693406
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38660008
147nuclear pore organization (GO:0006999)2.38578294
148modulation by virus of host process (GO:0019054)2.36711706
149regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34189230
150atrioventricular valve morphogenesis (GO:0003181)2.33612133
151epithelial cell-cell adhesion (GO:0090136)2.31398643
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.29375529
153developmental programmed cell death (GO:0010623)2.29229485
154positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28246766
155regulation of vitamin D biosynthetic process (GO:0060556)2.27802211
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.26627860
157dicarboxylic acid biosynthetic process (GO:0043650)2.25268484
158activation of JUN kinase activity (GO:0007257)2.25220311
159snRNA metabolic process (GO:0016073)2.24321594
160cellular response to virus (GO:0098586)2.24045395
161cell-cell junction maintenance (GO:0045217)2.23660714
162DNA unwinding involved in DNA replication (GO:0006268)2.23488516
163mRNA stabilization (GO:0048255)2.22843563
164RNA stabilization (GO:0043489)2.22843563
165negative regulation of striated muscle cell differentiation (GO:0051154)2.22841538
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.21910956
167positive regulation of extracellular matrix organization (GO:1903055)2.20322794
168regulation of chromatin binding (GO:0035561)2.20112009
169positive regulation of protein dephosphorylation (GO:0035307)2.19942685
170germinal center formation (GO:0002467)2.19713390
171NIK/NF-kappaB signaling (GO:0038061)2.19633748
172regulation of cholesterol storage (GO:0010885)2.18961667
173regulation of necroptotic process (GO:0060544)2.18707773
174negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.18256285
175positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.18162583
176regulation of monocyte differentiation (GO:0045655)2.17778526
177planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17426397
178cellular response to epidermal growth factor stimulus (GO:0071364)2.16432157
179modulation by virus of host morphology or physiology (GO:0019048)2.16235538
180positive regulation of protein deacetylation (GO:0090312)2.15782009
181protein complex localization (GO:0031503)2.14961214
182positive regulation of nuclease activity (GO:0032075)2.14878465
183skin morphogenesis (GO:0043589)2.14331680
184coronary vasculature morphogenesis (GO:0060977)2.13871747
185neural tube development (GO:0021915)2.13187778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.53538139
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.40509107
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.13007532
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.98176400
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.92512005
6VDR_21846776_ChIP-Seq_THP-1_Human2.79176934
7E2F7_22180533_ChIP-Seq_HELA_Human2.66872855
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56985297
9LXR_22292898_ChIP-Seq_THP-1_Human2.55762907
10MYC_22102868_ChIP-Seq_BL_Human2.48598270
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.47085664
12KDM2B_26808549_Chip-Seq_DND41_Human2.38479609
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30231836
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28051331
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.22186283
16* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.13897665
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11336164
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.10319226
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08231909
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08231909
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08231909
22ZNF263_19887448_ChIP-Seq_K562_Human2.08137809
23POU5F1_16518401_ChIP-PET_MESCs_Mouse2.07611798
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.06578035
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02265829
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01059619
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00815216
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96812589
29KDM2B_26808549_Chip-Seq_K562_Human1.95370884
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87606757
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.84060862
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81752745
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.81092728
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.80769166
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79692977
36RACK7_27058665_Chip-Seq_MCF-7_Human1.79660722
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.79514414
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79239482
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72986484
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67114315
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64814747
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.64504723
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64255963
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63083980
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60071210
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58637156
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.56775454
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50952055
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.45567364
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42399089
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42182923
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41772522
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41723561
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40513312
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38291577
56* TP53_22127205_ChIP-Seq_IMR90_Human1.38262210
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37820728
58CREB1_26743006_Chip-Seq_LNCaP_Human1.34652128
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33929821
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32637985
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32044947
62MAF_26560356_Chip-Seq_TH2_Human1.31598956
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30606916
64ATF3_27146783_Chip-Seq_COLON_Human1.30595616
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29161077
66CLOCK_20551151_ChIP-Seq_293T_Human1.29146040
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.28824696
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.28650311
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28462986
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26851329
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.26310924
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26237910
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.24844250
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24638593
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23107356
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.22436651
77NCOR1_26117541_ChIP-Seq_K562_Human1.19288612
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18868635
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.18130511
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17936455
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.17374261
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.17310928
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16530673
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16218595
85* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14949415
86* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14464077
87* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14413453
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12095802
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.12014603
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11379858
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11067737
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09882114
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09409562
94POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08760316
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08516715
96* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08456577
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08307981
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08306423
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07283197
100SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06978795
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06904214
102SCL_19346495_ChIP-Seq_HPC-7_Human1.06624655
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06117831
104P68_20966046_ChIP-Seq_HELA_Human1.05593472
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05495170
106NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05133176
107CTCF_27219007_Chip-Seq_Bcells_Human1.04940469
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.04582691
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04415473
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04280853
111RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03750012
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03670501
113UTX_26944678_Chip-Seq_JUKART_Human1.03453643
114TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03019731
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01883553
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01646582
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01458073
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01099951
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.00919147
120MAF_26560356_Chip-Seq_TH1_Human1.00569653
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00327657
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00231272
123SPI1_23127762_ChIP-Seq_K562_Human1.00206822
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99586279
125PHF8_20622854_ChIP-Seq_HELA_Human0.99325269
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.99102302
127* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99096686
128* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99096686
129* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98683318
130VDR_24763502_ChIP-Seq_THP-1_Human0.98646003
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98608434
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98495458
133ETS1_21867929_ChIP-Seq_TH2_Mouse0.98260897
134* SMC4_20622854_ChIP-Seq_HELA_Human0.98219107
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98017426
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97450063
137RING1B_27294783_Chip-Seq_NPCs_Mouse0.97056612
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.96887645
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96576278
140NANOG_16518401_ChIP-PET_MESCs_Mouse0.96551644
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96285499
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95527707
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95440589
144* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95079391
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94948477
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92908539
147* MITF_21258399_ChIP-Seq_MELANOMA_Human0.91268199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.52943749
2MP0008057_abnormal_DNA_replication4.27247667
3MP0005451_abnormal_body_composition3.93569089
4MP0010030_abnormal_orbit_morphology3.74852098
5MP0003172_abnormal_lysosome_physiology3.10795432
6MP0003283_abnormal_digestive_organ3.05722275
7MP0005171_absent_coat_pigmentation2.83469778
8MP0002877_abnormal_melanocyte_morpholog2.71195234
9MP0009840_abnormal_foam_cell2.70178948
10MP0003890_abnormal_embryonic-extraembry2.46204145
11MP0003705_abnormal_hypodermis_morpholog2.44736850
12MP0002009_preneoplasia2.34929207
13MP0002653_abnormal_ependyma_morphology2.29839082
14MP0003119_abnormal_digestive_system2.26457530
15MP0003303_peritoneal_inflammation2.22538391
16MP0005409_darkened_coat_color2.19846034
17MP0008438_abnormal_cutaneous_collagen1.98612970
18MP0003300_gastrointestinal_ulcer1.97441649
19MP0004510_myositis1.96615951
20MP0004133_heterotaxia1.91487096
21MP0003045_fibrosis1.91387909
22MP0001545_abnormal_hematopoietic_system1.89445254
23MP0005397_hematopoietic_system_phenotyp1.89445254
24MP0004808_abnormal_hematopoietic_stem1.87375432
25MP0005058_abnormal_lysosome_morphology1.86367614
26MP0000751_myopathy1.84864234
27MP0010352_gastrointestinal_tract_polyps1.82755361
28MP0008995_early_reproductive_senescence1.82152020
29MP0003453_abnormal_keratinocyte_physiol1.79210662
30MP0000569_abnormal_digit_pigmentation1.77997961
31MP0005257_abnormal_intraocular_pressure1.75272769
32MP0005174_abnormal_tail_pigmentation1.71811843
33MP0008260_abnormal_autophagy1.70584663
34MP0004197_abnormal_fetal_growth/weight/1.67336955
35MP0003436_decreased_susceptibility_to1.67195606
36MP0003763_abnormal_thymus_physiology1.63654121
37MP0000371_diluted_coat_color1.63102880
38* MP0004233_abnormal_muscle_weight1.62007474
39MP0002084_abnormal_developmental_patter1.61764140
40MP0004185_abnormal_adipocyte_glucose1.60306856
41MP0000747_muscle_weakness1.59792327
42MP0002089_abnormal_postnatal_growth/wei1.57151653
43MP0003329_amyloid_beta_deposits1.56498562
44MP0004947_skin_inflammation1.55952835
45MP0008961_abnormal_basal_metabolism1.52626236
46MP0004858_abnormal_nervous_system1.51848578
47* MP0002086_abnormal_extraembryonic_tissu1.50996917
48MP0002396_abnormal_hematopoietic_system1.50462276
49* MP0005076_abnormal_cell_differentiation1.49747559
50MP0002249_abnormal_larynx_morphology1.44574013
51* MP0000759_abnormal_skeletal_muscle1.42619752
52* MP0002269_muscular_atrophy1.40662885
53MP0010094_abnormal_chromosome_stability1.37573943
54MP0005085_abnormal_gallbladder_physiolo1.32576204
55MP0005365_abnormal_bile_salt1.32491658
56MP0002085_abnormal_embryonic_tissue1.31262779
57MP0005023_abnormal_wound_healing1.31012986
58MP0005645_abnormal_hypothalamus_physiol1.30615189
59MP0005380_embryogenesis_phenotype1.30393786
60MP0001672_abnormal_embryogenesis/_devel1.30393786
61MP0001697_abnormal_embryo_size1.28343352
62MP0001915_intracranial_hemorrhage1.27719585
63MP0010630_abnormal_cardiac_muscle1.26117185
64MP0003828_pulmonary_edema1.24653529
65MP0004859_abnormal_synaptic_plasticity1.24283207
66* MP0005621_abnormal_cell_physiology1.22186818
67MP0006072_abnormal_retinal_apoptosis1.21105567
68MP0000604_amyloidosis1.20775901
69MP0003566_abnormal_cell_adhesion1.19896709
70MP0001348_abnormal_lacrimal_gland1.19738162
71MP0001293_anophthalmia1.16474241
72MP0000579_abnormal_nail_morphology1.16141780
73MP0004087_abnormal_muscle_fiber1.14060132
74MP0000678_abnormal_parathyroid_gland1.12758596
75MP0003279_aneurysm1.12546420
76MP0010307_abnormal_tumor_latency1.12297783
77MP0010234_abnormal_vibrissa_follicle1.10890064
78MP0003984_embryonic_growth_retardation1.08548376
79MP0003137_abnormal_impulse_conducting1.07379449
80MP0002998_abnormal_bone_remodeling1.07065487
81MP0002060_abnormal_skin_morphology1.05751950
82MP0000767_abnormal_smooth_muscle1.05176322
83MP0005330_cardiomyopathy1.05038445
84MP0002088_abnormal_embryonic_growth/wei1.04670925
85MP0002282_abnormal_trachea_morphology1.03221360
86MP0004272_abnormal_basement_membrane1.02572335
87MP0009333_abnormal_splenocyte_physiolog1.00985079
88MP0002111_abnormal_tail_morphology0.99525393
89MP0005083_abnormal_biliary_tract0.99512662
90MP0000858_altered_metastatic_potential0.98655630
91MP0009053_abnormal_anal_canal0.98602352
92MP0000516_abnormal_urinary_system0.98232976
93MP0005367_renal/urinary_system_phenotyp0.98232976
94MP0001340_abnormal_eyelid_morphology0.98005190
95MP0003935_abnormal_craniofacial_develop0.97770689
96MP0003191_abnormal_cellular_cholesterol0.96432295
97MP0002796_impaired_skin_barrier0.95716641
98MP0003567_abnormal_fetal_cardiomyocyte0.95481196
99MP0001661_extended_life_span0.95225293
100MP0008877_abnormal_DNA_methylation0.95175625
101MP0004264_abnormal_extraembryonic_tissu0.94348135
102MP0000015_abnormal_ear_pigmentation0.93926111
103MP0008058_abnormal_DNA_repair0.91948907
104MP0005666_abnormal_adipose_tissue0.90641247
105MP0009046_muscle_twitch0.90002266
106MP0000350_abnormal_cell_proliferation0.88820778
107MP0001730_embryonic_growth_arrest0.88488203
108MP0009703_decreased_birth_body0.87440817
109MP0000733_abnormal_muscle_development0.87272361
110MP0004381_abnormal_hair_follicle0.87028480
111MP0000462_abnormal_digestive_system0.86526705
112MP0000639_abnormal_adrenal_gland0.85347859
113MP0002166_altered_tumor_susceptibility0.85126320
114MP0000537_abnormal_urethra_morphology0.85068000
115* MP0002080_prenatal_lethality0.84118710
116MP0000749_muscle_degeneration0.82847627
117MP0000003_abnormal_adipose_tissue0.82392974
118MP0005670_abnormal_white_adipose0.82148048
119MP0005375_adipose_tissue_phenotype0.81923147
120MP0006138_congestive_heart_failure0.81336360
121MP0000266_abnormal_heart_morphology0.81153380
122MP0000470_abnormal_stomach_morphology0.81060323
123MP0002932_abnormal_joint_morphology0.80906178
124MP0003111_abnormal_nucleus_morphology0.80833646
125MP0008770_decreased_survivor_rate0.80604395
126MP0001784_abnormal_fluid_regulation0.79666596
127MP0000703_abnormal_thymus_morphology0.79399756
128MP0003634_abnormal_glial_cell0.79153944
129MP0002925_abnormal_cardiovascular_devel0.78090929
130MP0009672_abnormal_birth_weight0.77319649
131MP0005501_abnormal_skin_physiology0.77300143
132* MP0005384_cellular_phenotype0.76728136
133MP0000955_abnormal_spinal_cord0.75544100
134MP0009931_abnormal_skin_appearance0.75475373
135MP0000685_abnormal_immune_system0.75115557
136MP0002697_abnormal_eye_size0.74833381
137MP0000467_abnormal_esophagus_morphology0.74288056
138MP0004145_abnormal_muscle_electrophysio0.74122485
139MP0001849_ear_inflammation0.73879134
140* MP0009115_abnormal_fat_cell0.73575048
141MP0002896_abnormal_bone_mineralization0.73499607
142MP0001324_abnormal_eye_pigmentation0.73303840
143* MP0002970_abnormal_white_adipose0.72377289
144MP0005623_abnormal_meninges_morphology0.72224203
145MP0003077_abnormal_cell_cycle0.72140240
146MP0002075_abnormal_coat/hair_pigmentati0.71391006
147MP0000750_abnormal_muscle_regeneration0.71104992
148MP0003861_abnormal_nervous_system0.70282685
149MP0001216_abnormal_epidermal_layer0.69185618
150MP0003091_abnormal_cell_migration0.68850840
151MP0000013_abnormal_adipose_tissue0.68006878
152MP0003075_altered_response_to0.66455463
153MP0000490_abnormal_crypts_of0.65076057
154MP0003115_abnormal_respiratory_system0.63289546

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.14639299
2Turricephaly (HP:0000262)4.44188424
3Annular pancreas (HP:0001734)4.38392667
4Cerebral aneurysm (HP:0004944)4.04993715
5Hypochromic microcytic anemia (HP:0004840)3.88209351
6Intestinal fistula (HP:0100819)3.70806836
7Ulnar bowing (HP:0003031)3.67547479
8Alopecia of scalp (HP:0002293)3.57522448
9Rectovaginal fistula (HP:0000143)3.51064600
10Rectal fistula (HP:0100590)3.51064600
11Facial hemangioma (HP:0000329)3.47285445
12Broad face (HP:0000283)3.47172884
13Pustule (HP:0200039)3.43719087
14Increased IgM level (HP:0003496)3.20157580
15Vaginal fistula (HP:0004320)3.13765195
16Concave nail (HP:0001598)3.13106151
17Urinary glycosaminoglycan excretion (HP:0003541)3.03998113
18Mucopolysacchariduria (HP:0008155)3.03998113
19Poikiloderma (HP:0001029)2.94542175
20Coronal craniosynostosis (HP:0004440)2.94314214
21Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94086108
22Abnormality of polysaccharide metabolism (HP:0011012)2.94086108
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94086108
24Intestinal atresia (HP:0011100)2.92513704
25Increased connective tissue (HP:0009025)2.90820429
26Congenital hip dislocation (HP:0001374)2.90038375
27Distal lower limb amyotrophy (HP:0008944)2.87255076
28Abnormality of the lower motor neuron (HP:0002366)2.86892504
29Orthostatic hypotension (HP:0001278)2.83841180
30Abnormality of the astrocytes (HP:0100707)2.79547489
31Astrocytoma (HP:0009592)2.79547489
32Abnormality of the aortic arch (HP:0012303)2.73690196
33Short humerus (HP:0005792)2.73355540
34Anteriorly placed anus (HP:0001545)2.70913972
35Abnormality of the fingertips (HP:0001211)2.68617459
36Protrusio acetabuli (HP:0003179)2.65639104
37Short chin (HP:0000331)2.61624546
38Broad alveolar ridges (HP:0000187)2.59446041
39Obstructive sleep apnea (HP:0002870)2.52270712
40Pancreatic islet-cell hyperplasia (HP:0004510)2.51206985
41Dysostosis multiplex (HP:0000943)2.50117525
42Male infertility (HP:0003251)2.49884476
43Achilles tendon contracture (HP:0001771)2.48113579
44Hamartoma (HP:0010566)2.47348968
45Albinism (HP:0001022)2.46932857
46Urethral obstruction (HP:0000796)2.42782511
47Large for gestational age (HP:0001520)2.41889607
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.41337613
49Vertebral fusion (HP:0002948)2.40909380
50Asymmetric septal hypertrophy (HP:0001670)2.40671574
51Vertebral hypoplasia (HP:0008417)2.40044834
52Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.40044834
53Premature rupture of membranes (HP:0001788)2.39932978
54Volvulus (HP:0002580)2.39615649
55Muscle fibrillation (HP:0010546)2.37393225
56Tented upper lip vermilion (HP:0010804)2.34285142
57Aplasia/hypoplasia of the humerus (HP:0006507)2.34212019
58Dislocated radial head (HP:0003083)2.33413522
59Tongue fasciculations (HP:0001308)2.32851992
60Disproportionate tall stature (HP:0001519)2.31117344
61Split hand (HP:0001171)2.28603046
62Exercise-induced myalgia (HP:0003738)2.27208373
63Flat acetabular roof (HP:0003180)2.27168089
64Distal upper limb amyotrophy (HP:0007149)2.23617379
65Upper limb amyotrophy (HP:0009129)2.23617379
66Vertebral compression fractures (HP:0002953)2.22993609
67Polycythemia (HP:0001901)2.22853374
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22592720
69Premature skin wrinkling (HP:0100678)2.20713407
70Difficulty climbing stairs (HP:0003551)2.20130607
71Alacrima (HP:0000522)2.20066648
72Abnormality of the Achilles tendon (HP:0005109)2.17940692
73Narrow nasal bridge (HP:0000446)2.17792374
74Hypercortisolism (HP:0001578)2.16168265
75Basal cell carcinoma (HP:0002671)2.16030539
76Abnormality of the thoracic spine (HP:0100711)2.15899682
77Lower limb amyotrophy (HP:0007210)2.14029404
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.13266511
79Progressive muscle weakness (HP:0003323)2.12408279
80Abnormality of the radial head (HP:0003995)2.11888331
81Long palpebral fissure (HP:0000637)2.11561742
82Increased cerebral lipofuscin (HP:0011813)2.09540105
83Abnormality of the periventricular white matter (HP:0002518)2.09283217
84Increased variability in muscle fiber diameter (HP:0003557)2.08782429
85Bowed forearm bones (HP:0003956)2.08356972
86Bowing of the arm (HP:0006488)2.08356972
87Broad thumb (HP:0011304)2.08199788
88Cerebral inclusion bodies (HP:0100314)2.06956226
89Clumsiness (HP:0002312)2.06746901
90Insomnia (HP:0100785)2.06616739
91Increased number of teeth (HP:0011069)2.05586052
92Acute lymphatic leukemia (HP:0006721)2.05553906
93Growth hormone excess (HP:0000845)2.05331734
94Ependymoma (HP:0002888)2.05256015
95Long eyelashes (HP:0000527)2.04394058
96Progressive hearing impairment (HP:0001730)2.03299347
97Sparse lateral eyebrow (HP:0005338)2.03241411
98Advanced eruption of teeth (HP:0006288)2.01482890
99Asymmetry of the thorax (HP:0001555)1.99523160
100Heterotopia (HP:0002282)1.99224055
101Glioma (HP:0009733)1.99055022
102Diaphragmatic weakness (HP:0009113)1.99002237
103Hypotelorism (HP:0000601)1.98994798
104Coarse hair (HP:0002208)1.98709184
105Dysmetric saccades (HP:0000641)1.97780937
106Abnormality of the columella (HP:0009929)1.96937676
107Natal tooth (HP:0000695)1.96342428
108Dysautonomia (HP:0002459)1.95364759
109Abnormality of the nasal septum (HP:0000419)1.94606120
110Spinal rigidity (HP:0003306)1.94058393
111Supranuclear gaze palsy (HP:0000605)1.93502212
112Short 5th finger (HP:0009237)1.93075175
113Aneurysm (HP:0002617)1.90157564
114Abnormality of skeletal muscle fiber size (HP:0012084)1.89709458
115Hypoplastic ischia (HP:0003175)1.89479055
116Elbow flexion contracture (HP:0002987)1.89180957
117Thin bony cortex (HP:0002753)1.88903615
118Hypochromic anemia (HP:0001931)1.88801542
119Hyperacusis (HP:0010780)1.88311094
120Colitis (HP:0002583)1.87261640
121Persistence of primary teeth (HP:0006335)1.87087533
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85065988
123Increased neuronal autofluorescent lipopigment (HP:0002074)1.84870798
124Shallow orbits (HP:0000586)1.84477073
125Fragile skin (HP:0001030)1.84249770
126Macroorchidism (HP:0000053)1.84125437
127Small hand (HP:0200055)1.84099044
128Choanal stenosis (HP:0000452)1.83672196
129Myocardial infarction (HP:0001658)1.83325978
130Atonic seizures (HP:0010819)1.83080987
131Mitral regurgitation (HP:0001653)1.81785810
132Squamous cell carcinoma (HP:0002860)1.81631557
133Abnormality of the pancreatic islet cells (HP:0006476)1.81521213
134Abnormality of endocrine pancreas physiology (HP:0012093)1.81521213
135Hemorrhage of the eye (HP:0011885)1.81059322
136Joint stiffness (HP:0001387)1.79712665
137Ankyloglossia (HP:0010296)1.79687211
138Mitral valve prolapse (HP:0001634)1.78545817
139Thoracic kyphosis (HP:0002942)1.77934230
140Pseudobulbar signs (HP:0002200)1.77234462
141Absent radius (HP:0003974)1.76371521
142Lower limb hyperreflexia (HP:0002395)1.75307545
143Abnormal ossification of hand bones (HP:0005921)1.75227274
144Progressive sensorineural hearing impairment (HP:0000408)1.74852044
145Pointed chin (HP:0000307)1.74795044
146Short nail (HP:0001799)1.74425548
147EMG: neuropathic changes (HP:0003445)1.73563035
148Distal lower limb muscle weakness (HP:0009053)1.73510590
149Neoplasm of the oral cavity (HP:0100649)1.73401542
150Patellar dislocation (HP:0002999)1.72821985
151Bulbar palsy (HP:0001283)1.72663805
152Abnormal hemoglobin (HP:0011902)1.72308047
153Neurofibrillary tangles (HP:0002185)1.71645017
154Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70908500
155Abnormality of male internal genitalia (HP:0000022)1.70605133
156Neuronal loss in central nervous system (HP:0002529)1.68272569
157Syringomyelia (HP:0003396)1.68228843
158Spinal cord lesions (HP:0100561)1.68228843
159Wormian bones (HP:0002645)1.66853766
160Onion bulb formation (HP:0003383)1.66506594
161Mildly elevated creatine phosphokinase (HP:0008180)1.66078189
162Supernumerary nipples (HP:0002558)1.65397686
163Abnormality of oral frenula (HP:0000190)1.63810602
164Bowel incontinence (HP:0002607)1.63459259
165Deep venous thrombosis (HP:0002625)1.62566619
166Genu recurvatum (HP:0002816)1.62254470
167Atrophic scars (HP:0001075)1.62242622
168Thin ribs (HP:0000883)1.61559969
169Abnormality of the calcaneus (HP:0008364)1.61338151
170Cervical subluxation (HP:0003308)1.61015407
171Abnormality of the distal phalanges of the toes (HP:0010182)1.60804295
172Generalized amyotrophy (HP:0003700)1.60772127
173Renal duplication (HP:0000075)1.60420566
174Myopathic facies (HP:0002058)1.59755576
175Osteolytic defects of the hand bones (HP:0009699)1.59297476
176Osteolytic defects of the phalanges of the hand (HP:0009771)1.59297476
177Subacute progressive viral hepatitis (HP:0006572)1.57389688
178Blue sclerae (HP:0000592)1.56470891
179Abnormal large intestine physiology (HP:0012700)1.54371470
180Upper motor neuron abnormality (HP:0002127)1.53470790
181Slow saccadic eye movements (HP:0000514)1.52739471
182Type 1 muscle fiber predominance (HP:0003803)1.52636497
183Renovascular hypertension (HP:0100817)1.52327034
184Abnormality of glycolipid metabolism (HP:0010969)1.51981770
185Abnormality of liposaccharide metabolism (HP:0010968)1.51981770
186Abnormality of glycosphingolipid metabolism (HP:0004343)1.51981770
187Ragged-red muscle fibers (HP:0003200)1.51407478
188Nuclear cataract (HP:0100018)1.51365660
189Stridor (HP:0010307)1.51121247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.42563579
2MAPK154.28432939
3SMG13.80090765
4MAP3K63.53327285
5TYRO33.39553220
6IRAK33.14982306
7MAP3K113.12752222
8PDGFRA2.62256160
9PINK12.55392066
10FGR2.44523212
11MATK2.36396157
12CDK122.36331514
13BMX2.28409288
14MAP3K102.28315402
15DAPK12.03977055
16TRIB32.03242053
17UHMK11.99508543
18PRKD21.98359749
19PIM21.88631627
20CSK1.83692554
21DYRK1B1.76580663
22NME21.74868557
23MAP3K91.63802975
24* ICK1.54667761
25CDK61.46518649
26CDC42BPA1.39544044
27LATS21.38125455
28TAOK21.36990517
29RIPK11.35185429
30AKT31.33089324
31MST1R1.31531800
32PHKG21.29261610
33PHKG11.29261610
34TAOK11.26676058
35CAMK1D1.19638600
36EEF2K1.18387457
37* MTOR1.14579445
38CAMK1G1.12572836
39MAP3K31.07151952
40YES11.06795905
41SIK21.06732795
42PIM11.05474435
43CDK71.03262647
44TRPM71.01214227
45GSK3A0.98431727
46MAP3K140.92046954
47MAP3K10.91096903
48SIK10.90919427
49PDPK10.88785966
50RPS6KA20.85287016
51MELK0.84240615
52MARK20.83532357
53PRKD30.83382707
54PTK60.81398185
55PDGFRB0.79275841
56* MAPK110.79126554
57PKN20.77553702
58RAF10.77273713
59TTN0.76420554
60HIPK20.76356640
61STK380.76172533
62KSR20.73839599
63DMPK0.73680223
64MAP4K10.72479827
65MAP3K80.72199677
66ALK0.71921005
67PRPF4B0.71034314
68CDK90.68019355
69NTRK20.67733556
70PAK60.64356770
71PAK40.64140154
72ERN10.64049100
73* PRKAA10.62423557
74MAPK120.62016331
75PRKAA20.61059158
76SGK30.61042334
77PTK20.59731272
78LMTK20.59194362
79PDK10.56915813
80NEK20.56633203
81MAP2K20.56174153
82RPS6KB20.55845735
83RET0.54540707
84NTRK10.54368727
85LATS10.54366158
86EPHB10.53814271
87RPS6KB10.53493769
88FGFR10.53336586
89MOS0.53066814
90ZAP700.52561050
91EGFR0.51820659
92CAMKK10.51541986
93* RPS6KA10.51316825
94CDK80.51132391
95SGK10.50894699
96NEK90.50741566
97MAP3K70.50578831
98MAPK100.50117358
99MET0.48566625
100CHEK10.48048136
101FGFR40.47618354
102PAK20.47429402
103CHEK20.46761326
104BRD40.46734915
105CDK20.45531619
106IRAK20.45334002
107PRKD10.44718693
108BRAF0.44137028
109TBK10.43334129
110ARAF0.42534047
111* RPS6KC10.41501171
112* RPS6KL10.41501171
113MAP3K130.39958279
114RPS6KA30.39293711
115MAPK140.38800702
116PRKCZ0.38079703
117* MAPK10.37540055
118BLK0.36500765
119MAP2K30.34686496
120MAPK40.34623324
121SCYL20.34598508
122CHUK0.34514533
123JAK20.34354857
124AKT20.33613063
125MAP3K40.33443410
126FGFR30.32880678
127INSR0.32804809
128MAPK80.32798771
129CDK40.32184408
130ATR0.31127707
131AKT10.30686766
132JAK30.29989665
133WNK10.29842529
134* RPS6KA60.29491945
135CAMK40.29156153
136TGFBR20.28196405
137GSK3B0.28058621
138MAP3K50.27787482
139PLK10.26601205
140EPHA20.26114221

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.50541768
2Other glycan degradation_Homo sapiens_hsa005112.42920045
3Lysine degradation_Homo sapiens_hsa003102.21206770
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20885909
5* mTOR signaling pathway_Homo sapiens_hsa041502.19619425
6Base excision repair_Homo sapiens_hsa034102.16211772
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06316487
8Notch signaling pathway_Homo sapiens_hsa043302.03159096
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91292441
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82441916
11Mismatch repair_Homo sapiens_hsa034301.82099365
12Arginine biosynthesis_Homo sapiens_hsa002201.70324060
13Adherens junction_Homo sapiens_hsa045201.69502107
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55627053
15Fatty acid metabolism_Homo sapiens_hsa012121.54771549
16Hippo signaling pathway_Homo sapiens_hsa043901.53826553
17Circadian rhythm_Homo sapiens_hsa047101.46723542
18Nitrogen metabolism_Homo sapiens_hsa009101.44727135
19* Longevity regulating pathway - mammal_Homo sapiens_hsa042111.39917596
20VEGF signaling pathway_Homo sapiens_hsa043701.39179777
21Hedgehog signaling pathway_Homo sapiens_hsa043401.38044057
22Chronic myeloid leukemia_Homo sapiens_hsa052201.37767555
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37734169
24Thyroid cancer_Homo sapiens_hsa052161.34649318
25mRNA surveillance pathway_Homo sapiens_hsa030151.32576247
26TNF signaling pathway_Homo sapiens_hsa046681.27628679
27Dorso-ventral axis formation_Homo sapiens_hsa043201.26524631
28Bladder cancer_Homo sapiens_hsa052191.22878204
29ErbB signaling pathway_Homo sapiens_hsa040121.21217978
30Biosynthesis of amino acids_Homo sapiens_hsa012301.19669839
31Osteoclast differentiation_Homo sapiens_hsa043801.17918669
32Renal cell carcinoma_Homo sapiens_hsa052111.17839097
33Colorectal cancer_Homo sapiens_hsa052101.16167097
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.14153811
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.09538153
36* Insulin signaling pathway_Homo sapiens_hsa049101.08332136
37Acute myeloid leukemia_Homo sapiens_hsa052211.08235850
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08088373
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07823980
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05947289
41Pentose phosphate pathway_Homo sapiens_hsa000301.02766008
42Apoptosis_Homo sapiens_hsa042101.02509542
43Basal cell carcinoma_Homo sapiens_hsa052171.00093877
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98788940
45Type II diabetes mellitus_Homo sapiens_hsa049300.97665456
46Wnt signaling pathway_Homo sapiens_hsa043100.97241395
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96550756
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.95743778
49Endometrial cancer_Homo sapiens_hsa052130.95150369
50Choline metabolism in cancer_Homo sapiens_hsa052310.94719789
51Inositol phosphate metabolism_Homo sapiens_hsa005620.94713545
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94233392
53Amoebiasis_Homo sapiens_hsa051460.92645941
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92409972
55Estrogen signaling pathway_Homo sapiens_hsa049150.92392649
56T cell receptor signaling pathway_Homo sapiens_hsa046600.91359087
57Viral myocarditis_Homo sapiens_hsa054160.91344911
58Gap junction_Homo sapiens_hsa045400.90218624
59Toxoplasmosis_Homo sapiens_hsa051450.89814157
60HTLV-I infection_Homo sapiens_hsa051660.88822095
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88010013
62Hepatitis C_Homo sapiens_hsa051600.87719891
63* AMPK signaling pathway_Homo sapiens_hsa041520.87503470
64Glucagon signaling pathway_Homo sapiens_hsa049220.87137172
65TGF-beta signaling pathway_Homo sapiens_hsa043500.86938154
66Arginine and proline metabolism_Homo sapiens_hsa003300.86707945
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86579368
68Insulin resistance_Homo sapiens_hsa049310.85799128
69Lysosome_Homo sapiens_hsa041420.85603596
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85438653
71MAPK signaling pathway_Homo sapiens_hsa040100.83320593
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83046697
73Glioma_Homo sapiens_hsa052140.82682736
74GnRH signaling pathway_Homo sapiens_hsa049120.81745645
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.81117505
76* MicroRNAs in cancer_Homo sapiens_hsa052060.80321251
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80236781
78Proteoglycans in cancer_Homo sapiens_hsa052050.80046137
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79544967
80Influenza A_Homo sapiens_hsa051640.78834229
81Non-small cell lung cancer_Homo sapiens_hsa052230.78510577
82FoxO signaling pathway_Homo sapiens_hsa040680.77921195
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.76881506
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75851209
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74490461
86B cell receptor signaling pathway_Homo sapiens_hsa046620.73463194
87Shigellosis_Homo sapiens_hsa051310.71798008
88DNA replication_Homo sapiens_hsa030300.71465884
89Oocyte meiosis_Homo sapiens_hsa041140.71092545
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70815302
91Pancreatic cancer_Homo sapiens_hsa052120.68158149
92Focal adhesion_Homo sapiens_hsa045100.66989951
93ECM-receptor interaction_Homo sapiens_hsa045120.66826793
94Vitamin B6 metabolism_Homo sapiens_hsa007500.66737197
95Dilated cardiomyopathy_Homo sapiens_hsa054140.66265423
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66132605
97Olfactory transduction_Homo sapiens_hsa047400.65648256
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.65639783
99Fructose and mannose metabolism_Homo sapiens_hsa000510.65567634
100Small cell lung cancer_Homo sapiens_hsa052220.65163246
101Prion diseases_Homo sapiens_hsa050200.64520708
102Galactose metabolism_Homo sapiens_hsa000520.64206366
103ABC transporters_Homo sapiens_hsa020100.63935608
104Measles_Homo sapiens_hsa051620.63840788
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62890090
106* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61480091
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61283697
108Tight junction_Homo sapiens_hsa045300.61178601
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59437755
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.57453466
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56991598
112Salmonella infection_Homo sapiens_hsa051320.56236681
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.55895148
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.55636971
115Bile secretion_Homo sapiens_hsa049760.55512989
116Pathways in cancer_Homo sapiens_hsa052000.55060763
117Herpes simplex infection_Homo sapiens_hsa051680.54946898
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.53809223
119Melanoma_Homo sapiens_hsa052180.53622863
120p53 signaling pathway_Homo sapiens_hsa041150.53585601
121Rap1 signaling pathway_Homo sapiens_hsa040150.53223757
122Platelet activation_Homo sapiens_hsa046110.52836516
123Tuberculosis_Homo sapiens_hsa051520.52595228
124Oxytocin signaling pathway_Homo sapiens_hsa049210.52313789
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52306775
126Long-term potentiation_Homo sapiens_hsa047200.51781404
127Systemic lupus erythematosus_Homo sapiens_hsa053220.50286175
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50203312
129Endocytosis_Homo sapiens_hsa041440.47042548
130GABAergic synapse_Homo sapiens_hsa047270.46955237
131Viral carcinogenesis_Homo sapiens_hsa052030.45736307
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44780434
133Melanogenesis_Homo sapiens_hsa049160.41938444
134Prostate cancer_Homo sapiens_hsa052150.41871251
135Prolactin signaling pathway_Homo sapiens_hsa049170.39393973
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39367130
137Primary immunodeficiency_Homo sapiens_hsa053400.38104646
138Hepatitis B_Homo sapiens_hsa051610.37455844
139HIF-1 signaling pathway_Homo sapiens_hsa040660.36397783
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35827304

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