RPUSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.03019741
2synaptic vesicle exocytosis (GO:0016079)5.92820039
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77787636
4glutamate secretion (GO:0014047)5.44056266
5synaptic vesicle maturation (GO:0016188)5.34435254
6regulation of synaptic vesicle exocytosis (GO:2000300)5.26934680
7neuronal action potential propagation (GO:0019227)4.91078871
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81592475
9vocalization behavior (GO:0071625)4.80759384
10regulation of synaptic vesicle transport (GO:1902803)4.78418940
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64186754
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63701692
13regulation of mammary gland epithelial cell proliferation (GO:0033599)4.55183264
14proline biosynthetic process (GO:0006561)4.44774791
15locomotory exploration behavior (GO:0035641)4.41425583
16protein localization to synapse (GO:0035418)4.40584841
17positive regulation of synapse maturation (GO:0090129)4.37723902
18neurotransmitter secretion (GO:0007269)4.35482415
19ribosomal small subunit biogenesis (GO:0042274)4.33919524
20regulation of glutamate receptor signaling pathway (GO:1900449)4.32773551
21GDP-mannose metabolic process (GO:0019673)4.32362734
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.31209257
23neurotransmitter-gated ion channel clustering (GO:0072578)4.19477974
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17030601
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08306992
26regulation of neuronal synaptic plasticity (GO:0048168)4.05659431
27DNA unwinding involved in DNA replication (GO:0006268)3.95591738
28neuron cell-cell adhesion (GO:0007158)3.92741037
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92384219
30synaptic transmission, glutamatergic (GO:0035249)3.83787995
31COPI coating of Golgi vesicle (GO:0048205)3.80660135
32Golgi transport vesicle coating (GO:0048200)3.80660135
33negative regulation of cell size (GO:0045792)3.75152693
34neuromuscular process controlling posture (GO:0050884)3.70079999
35neuron-neuron synaptic transmission (GO:0007270)3.68201057
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67673179
37positive regulation of membrane potential (GO:0045838)3.66983280
38apoptotic process involved in morphogenesis (GO:0060561)3.65638387
39regulation of translational fidelity (GO:0006450)3.62053935
40regulation of synapse structural plasticity (GO:0051823)3.60552564
41positive regulation of neurotransmitter transport (GO:0051590)3.56236875
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.53658579
43pentose-phosphate shunt (GO:0006098)3.50042673
44neurotransmitter transport (GO:0006836)3.46911923
45ncRNA 3-end processing (GO:0043628)3.46540500
46positive regulation of neurotransmitter secretion (GO:0001956)3.45406756
47long-term memory (GO:0007616)3.44267987
48exploration behavior (GO:0035640)3.44089515
49regulation of synaptic plasticity (GO:0048167)3.44087743
50activation of protein kinase A activity (GO:0034199)3.43847920
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.42230025
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.35699352
53long-term synaptic potentiation (GO:0060291)3.35655738
54regulation of synapse maturation (GO:0090128)3.34537251
55postsynaptic membrane organization (GO:0001941)3.34173972
56DNA strand elongation (GO:0022616)3.32729010
57synaptic vesicle endocytosis (GO:0048488)3.31972165
58DNA replication initiation (GO:0006270)3.31903704
59rRNA transcription (GO:0009303)3.31705774
60DNA strand elongation involved in DNA replication (GO:0006271)3.30908917
61transferrin transport (GO:0033572)3.30437684
62regulation of neurotransmitter secretion (GO:0046928)3.29350386
63ATP hydrolysis coupled proton transport (GO:0015991)3.26853593
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26853593
65pentose metabolic process (GO:0019321)3.25762659
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25603565
67positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.24742677
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24685033
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23885017
70nuclear envelope reassembly (GO:0031468)3.23013986
71mitotic nuclear envelope reassembly (GO:0007084)3.23013986
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.21745701
73formation of translation preinitiation complex (GO:0001731)3.21263797
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20533271
75regulation of neurotransmitter levels (GO:0001505)3.19576505
76regulation of mitochondrial translation (GO:0070129)3.19474305
77gamma-aminobutyric acid transport (GO:0015812)3.18752638
78auditory behavior (GO:0031223)3.17647024
79regulation of neurotransmitter transport (GO:0051588)3.16410567
80negative regulation of erythrocyte differentiation (GO:0045647)3.16262243
81regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.11999951
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.11999951
83activation of Rac GTPase activity (GO:0032863)3.11796155
84glutamate receptor signaling pathway (GO:0007215)3.06683967
85synaptic vesicle transport (GO:0048489)3.06345539
86establishment of synaptic vesicle localization (GO:0097480)3.06345539
87UV protection (GO:0009650)3.05909497
88regulation of postsynaptic membrane potential (GO:0060078)3.04887083
89nucleobase-containing small molecule interconversion (GO:0015949)3.04554463
90glucose catabolic process (GO:0006007)3.03676201
91mitochondrial fusion (GO:0008053)3.02187747
92striatum development (GO:0021756)3.00725351
93viral transcription (GO:0019083)3.00651311
94NADH metabolic process (GO:0006734)2.99686588
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99391194
96trivalent inorganic cation transport (GO:0072512)2.99053829
97ferric iron transport (GO:0015682)2.99053829
98regulation of vesicle fusion (GO:0031338)2.97503016
99mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.97092369
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.95731621
101NADPH regeneration (GO:0006740)2.95649351
102viral mRNA export from host cell nucleus (GO:0046784)2.95609670
103negative regulation of microtubule polymerization (GO:0031115)2.95257531
104maturation of SSU-rRNA (GO:0030490)2.94108341
105positive regulation of synaptic transmission (GO:0050806)2.93305464
106regulation of synaptic transmission, GABAergic (GO:0032228)2.93108208
107telomere maintenance via semi-conservative replication (GO:0032201)2.93087664
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93087007
109protein retention in ER lumen (GO:0006621)2.92093919
110negative regulation of cation channel activity (GO:2001258)2.92075025
111NIK/NF-kappaB signaling (GO:0038061)2.91989917
112behavioral fear response (GO:0001662)2.91245656
113behavioral defense response (GO:0002209)2.91245656
1143-UTR-mediated mRNA stabilization (GO:0070935)2.90899266
115positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90728906
116proline transport (GO:0015824)2.89473462
117maternal placenta development (GO:0001893)2.89410298
118negative regulation of dendrite morphogenesis (GO:0050774)2.89214330
119adenine nucleotide transport (GO:0051503)2.89205472
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89176448
121regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.88524281
122ribonucleoprotein complex biogenesis (GO:0022613)2.88478623
123positive regulation of Cdc42 GTPase activity (GO:0043089)2.88163238
124protein complex localization (GO:0031503)2.87770874
125regulation of synaptic transmission (GO:0050804)2.86769725
126negative regulation of DNA-templated transcription, elongation (GO:0032785)2.86765050
127proline metabolic process (GO:0006560)2.86033967
128negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.85933107
129synaptic transmission (GO:0007268)2.84837074
130pyrimidine-containing compound salvage (GO:0008655)2.84473111
131pyrimidine nucleoside salvage (GO:0043097)2.84473111
132mitotic chromosome condensation (GO:0007076)2.83713366
133modulation by virus of host process (GO:0019054)2.83372937
134intracellular estrogen receptor signaling pathway (GO:0030520)2.82829170
135peptidyl-arginine methylation (GO:0018216)2.82742996
136peptidyl-arginine N-methylation (GO:0035246)2.82742996
137nucleotide salvage (GO:0043173)2.82334989
138protein maturation by protein folding (GO:0022417)2.82024424
139protein insertion into membrane (GO:0051205)2.81545526
140regulation of translational termination (GO:0006449)2.81111980
141detection of calcium ion (GO:0005513)2.81001128
142mechanosensory behavior (GO:0007638)2.80907186
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78873040
144retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77301239
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77174704
146fear response (GO:0042596)2.77150819
147peptidyl-arginine omega-N-methylation (GO:0035247)2.76772779
148base-excision repair, AP site formation (GO:0006285)2.76760468
149response to auditory stimulus (GO:0010996)2.75849217
150tRNA methylation (GO:0030488)2.75796990
151pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.75384381
152chaperone-mediated protein transport (GO:0072321)2.73332769
153guanosine-containing compound biosynthetic process (GO:1901070)2.73272737
154histone arginine methylation (GO:0034969)2.73212688
155cellular potassium ion homeostasis (GO:0030007)2.72601010
156establishment of vesicle localization (GO:0051650)2.72001132
157ribosome biogenesis (GO:0042254)2.70694268
158membrane depolarization during action potential (GO:0086010)2.70475567
159regulation of protein kinase A signaling (GO:0010738)2.68817646
160protein localization to endosome (GO:0036010)2.68156881
161behavioral response to cocaine (GO:0048148)2.67140106
162nucleosome disassembly (GO:0006337)2.66765832
163protein-DNA complex disassembly (GO:0032986)2.66765832
164regulation of voltage-gated calcium channel activity (GO:1901385)2.66740351
165response to histamine (GO:0034776)2.66400871
166vesicle docking involved in exocytosis (GO:0006904)2.66395483
167translational termination (GO:0006415)2.66302403
168regulation of neurotransmitter uptake (GO:0051580)2.66084566
169positive regulation of keratinocyte differentiation (GO:0045618)2.65795061
170maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.65720871
171translational elongation (GO:0006414)2.65658061
172pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.64899621
173folic acid metabolic process (GO:0046655)2.64415283
174ribosomal small subunit assembly (GO:0000028)2.64371774
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60566604
176negative regulation of viral release from host cell (GO:1902187)2.58679925
177UTP biosynthetic process (GO:0006228)2.57640785
178modulation by symbiont of host cellular process (GO:0044068)2.56987462
179T cell apoptotic process (GO:0070231)2.55544814
180transcription from mitochondrial promoter (GO:0006390)2.54394696
181snRNA metabolic process (GO:0016073)2.51490876
182chaperone mediated protein folding requiring cofactor (GO:0051085)2.51405826
183negative regulation of B cell apoptotic process (GO:0002903)2.51244779
184adherens junction assembly (GO:0034333)2.50901214
185positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49727019
186pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.49689556
187focal adhesion assembly (GO:0048041)2.48823267
188cell-substrate adherens junction assembly (GO:0007045)2.48823267
189purine deoxyribonucleotide catabolic process (GO:0009155)2.48365305
190cellular protein complex localization (GO:0034629)2.48314049
191viral life cycle (GO:0019058)2.47947806
192pinocytosis (GO:0006907)2.47779439
193negative regulation of mRNA metabolic process (GO:1903312)2.46599480
194purine ribonucleotide transport (GO:0015868)2.45636496
195negative regulation of mRNA processing (GO:0050686)2.45460030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84679435
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.30977926
3GBX2_23144817_ChIP-Seq_PC3_Human3.28552194
4E2F7_22180533_ChIP-Seq_HELA_Human3.16093897
5REST_21632747_ChIP-Seq_MESCs_Mouse3.05623109
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02432988
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.92714488
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.89950915
9VDR_21846776_ChIP-Seq_THP-1_Human2.86938032
10MYC_22102868_ChIP-Seq_BL_Human2.71116527
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.64505292
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61545878
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54086220
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53063996
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.52387747
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49096628
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.40455306
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31211628
19LXR_22292898_ChIP-Seq_THP-1_Human2.30123721
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26295707
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.23089536
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20850192
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.18849082
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15839632
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15538585
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09053675
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07382226
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.05015619
29* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04011859
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02011444
31* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.96858939
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95221095
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90798497
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.88583993
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88170973
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.86271882
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84703569
38ZNF263_19887448_ChIP-Seq_K562_Human1.82729120
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79776538
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76772419
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75095522
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74105058
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73431799
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73431799
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73044571
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.73022957
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68972846
48DROSHA_22980978_ChIP-Seq_HELA_Human1.64400951
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62644949
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.62587826
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.61089229
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59200388
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59174280
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58881443
55P68_20966046_ChIP-Seq_HELA_Human1.58222100
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56717445
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.54928824
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53021802
59KDM2B_26808549_Chip-Seq_DND41_Human1.51133179
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51116146
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51085962
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.51043317
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.49946275
64* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49364360
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47096300
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46889300
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.46068616
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45991066
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45527296
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.45151048
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43083278
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41204386
73TCF7_22412390_ChIP-Seq_EML_Mouse1.40162532
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39969146
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39557240
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38642091
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38534382
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37832687
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35512234
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34121797
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33885382
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.32961774
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32848662
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32457955
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32051194
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30487342
87VDR_24763502_ChIP-Seq_THP-1_Human1.29192993
88GABP_19822575_ChIP-Seq_HepG2_Human1.27351872
89MAF_26560356_Chip-Seq_TH2_Human1.26174969
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25228442
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.23974715
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22929566
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22789466
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22333650
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21395781
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.20532679
97MAF_26560356_Chip-Seq_TH1_Human1.19573833
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19365777
99* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19099065
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16939283
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16478506
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16065727
103ATF3_27146783_Chip-Seq_COLON_Human1.15226300
104KDM5A_27292631_Chip-Seq_BREAST_Human1.14921770
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14795923
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.14565995
107CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14122284
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13059895
109NCOR1_26117541_ChIP-Seq_K562_Human1.11922767
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11724533
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11396619
112* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11143174
113UTX_26944678_Chip-Seq_JUKART_Human1.10548517
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10534368
115BCOR_27268052_Chip-Seq_Bcells_Human1.10495283
116TTF2_22483619_ChIP-Seq_HELA_Human1.10301508
117* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09867477
118BCL6_27268052_Chip-Seq_Bcells_Human1.09861182
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.09571290
120ZNF274_21170338_ChIP-Seq_K562_Hela1.09551119
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08609394
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08473561
123MYC_18555785_ChIP-Seq_MESCs_Mouse1.08048494
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07720222
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06539214
126KDM2B_26808549_Chip-Seq_K562_Human1.04809715
127ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04758889
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04450956
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03993099
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03874905
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03720771
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03554749
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03157922
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02859790
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.02406131
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.02338727
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02027548
138* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00794505
139XRN2_22483619_ChIP-Seq_HELA_Human0.98387314
140* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96877693
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93888624
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.93252683
143E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91472787
144TAF15_26573619_Chip-Seq_HEK293_Human0.90403353
145* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88806041
146CIITA_25753668_ChIP-Seq_RAJI_Human0.87933809
147MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87276136
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.84555161
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84047118
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.81758345
151SMAD4_21799915_ChIP-Seq_A2780_Human0.81019704
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81014406
153FOXP1_21924763_ChIP-Seq_HESCs_Human0.80186045
154REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80148434
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.79643969
156* TET1_21451524_ChIP-Seq_MESCs_Mouse0.79386271
157POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.78734311
158TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78491397
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77807803
160SOX2_21211035_ChIP-Seq_LN229_Gbm0.77790246
161* SMC4_20622854_ChIP-Seq_HELA_Human0.77738171
162GATA1_26923725_Chip-Seq_HPCs_Mouse0.76378795
163DCP1A_22483619_ChIP-Seq_HELA_Human0.76365462
164E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76163335
165JUN_21703547_ChIP-Seq_K562_Human0.74984279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.10332157
2MP0003880_abnormal_central_pattern4.46941689
3MP0002822_catalepsy4.09068274
4MP0003635_abnormal_synaptic_transmissio3.98798869
5MP0005451_abnormal_body_composition3.57034831
6MP0003705_abnormal_hypodermis_morpholog3.46957501
7MP0009745_abnormal_behavioral_response3.27953556
8MP0005058_abnormal_lysosome_morphology3.27702693
9MP0004270_analgesia3.21199552
10MP0002064_seizures3.19475360
11MP0009046_muscle_twitch3.18636258
12MP0002063_abnormal_learning/memory/cond3.15540766
13MP0001968_abnormal_touch/_nociception2.92242612
14MP0004185_abnormal_adipocyte_glucose2.88914008
15MP0002572_abnormal_emotion/affect_behav2.69475498
16MP0002272_abnormal_nervous_system2.59163487
17MP0002736_abnormal_nociception_after2.57649165
18MP0002734_abnormal_mechanical_nocicepti2.55890441
19MP0003111_abnormal_nucleus_morphology2.53117718
20MP0002735_abnormal_chemical_nociception2.47852440
21MP0001849_ear_inflammation2.46427533
22MP0003693_abnormal_embryo_hatching2.43457014
23MP0002877_abnormal_melanocyte_morpholog2.38941645
24MP0008260_abnormal_autophagy2.34727769
25MP0005076_abnormal_cell_differentiation2.31447997
26MP0010234_abnormal_vibrissa_follicle2.29196625
27MP0009278_abnormal_bone_marrow2.28253625
28MP0001486_abnormal_startle_reflex2.16845192
29MP0000537_abnormal_urethra_morphology2.12773380
30MP0009333_abnormal_splenocyte_physiolog2.08162709
31MP0005501_abnormal_skin_physiology2.06311280
32MP0003879_abnormal_hair_cell2.05390259
33MP0010094_abnormal_chromosome_stability2.04413171
34MP0001970_abnormal_pain_threshold2.03030921
35MP0005646_abnormal_pituitary_gland2.01876478
36MP0001501_abnormal_sleep_pattern2.01076324
37MP0002733_abnormal_thermal_nociception1.95803771
38MP0002796_impaired_skin_barrier1.92435937
39MP0001529_abnormal_vocalization1.91255187
40MP0005423_abnormal_somatic_nervous1.91165365
41MP0004957_abnormal_blastocyst_morpholog1.90024287
42MP0001440_abnormal_grooming_behavior1.89388206
43MP0003787_abnormal_imprinting1.87858494
44MP0008569_lethality_at_weaning1.80405182
45MP0003191_abnormal_cellular_cholesterol1.79939490
46MP0003123_paternal_imprinting1.79679429
47MP0000490_abnormal_crypts_of1.78706227
48MP0003077_abnormal_cell_cycle1.78173042
49MP0004811_abnormal_neuron_physiology1.76546590
50MP0003122_maternal_imprinting1.75865968
51MP0001984_abnormal_olfaction1.72972336
52MP0002249_abnormal_larynx_morphology1.72243481
53MP0002067_abnormal_sensory_capabilities1.70815554
54MP0002184_abnormal_innervation1.68459194
55MP0003453_abnormal_keratinocyte_physiol1.65236758
56MP0009840_abnormal_foam_cell1.61236159
57MP0002557_abnormal_social/conspecific_i1.61090158
58MP0008932_abnormal_embryonic_tissue1.60309219
59MP0001730_embryonic_growth_arrest1.59707716
60MP0005386_behavior/neurological_phenoty1.56729989
61MP0004924_abnormal_behavior1.56729989
62MP0008877_abnormal_DNA_methylation1.56499959
63MP0003436_decreased_susceptibility_to1.55164535
64MP0002909_abnormal_adrenal_gland1.54253224
65MP0010030_abnormal_orbit_morphology1.53203135
66MP0009780_abnormal_chondrocyte_physiolo1.52129373
67MP0003806_abnormal_nucleotide_metabolis1.50923660
68MP0000350_abnormal_cell_proliferation1.49444855
69MP0000858_altered_metastatic_potential1.49223688
70MP0000013_abnormal_adipose_tissue1.47738235
71MP0005666_abnormal_adipose_tissue1.46996745
72MP0003303_peritoneal_inflammation1.46329226
73MP0004858_abnormal_nervous_system1.44810443
74MP0001905_abnormal_dopamine_level1.43385245
75MP0008007_abnormal_cellular_replicative1.36929788
76MP0006276_abnormal_autonomic_nervous1.35878542
77MP0008872_abnormal_physiological_respon1.35874576
78MP0003786_premature_aging1.35408557
79MP0001873_stomach_inflammation1.35299763
80MP0002066_abnormal_motor_capabilities/c1.34623128
81MP0005623_abnormal_meninges_morphology1.31938772
82MP0002132_abnormal_respiratory_system1.30887738
83MP0001348_abnormal_lacrimal_gland1.29930226
84MP0000955_abnormal_spinal_cord1.29578847
85MP0003566_abnormal_cell_adhesion1.29241754
86MP0000313_abnormal_cell_death1.28411201
87MP0000003_abnormal_adipose_tissue1.27245221
88MP0003763_abnormal_thymus_physiology1.26614046
89MP0005375_adipose_tissue_phenotype1.25709332
90MP0001188_hyperpigmentation1.25236676
91MP0003329_amyloid_beta_deposits1.25006732
92MP0004142_abnormal_muscle_tone1.24310191
93MP0002837_dystrophic_cardiac_calcinosis1.24137399
94MP0002396_abnormal_hematopoietic_system1.24127003
95MP0002882_abnormal_neuron_morphology1.23568849
96MP0002080_prenatal_lethality1.19813959
97MP0004947_skin_inflammation1.18459631
98MP0005645_abnormal_hypothalamus_physiol1.15646690
99MP0002089_abnormal_postnatal_growth/wei1.13902280
100MP0001853_heart_inflammation1.13687093
101MP0003283_abnormal_digestive_organ1.13582513
102MP0004381_abnormal_hair_follicle1.13128186
103MP0000751_myopathy1.11407450
104MP0001346_abnormal_lacrimal_gland1.10685356
105MP0002876_abnormal_thyroid_physiology1.08158888
106MP0000733_abnormal_muscle_development1.06223948
107MP0010386_abnormal_urinary_bladder1.05427010
108MP0003172_abnormal_lysosome_physiology1.05379164
109MP0000681_abnormal_thyroid_gland1.04431653
110MP0000703_abnormal_thymus_morphology1.03098258
111MP0001986_abnormal_taste_sensitivity1.02517006
112MP0003121_genomic_imprinting1.02328399
113MP0003633_abnormal_nervous_system1.01410062
114MP0009931_abnormal_skin_appearance1.01210117
115MP0001216_abnormal_epidermal_layer1.00912154
116MP0001727_abnormal_embryo_implantation1.00848831
117MP0002019_abnormal_tumor_incidence1.00428279
118MP0002653_abnormal_ependyma_morphology1.00249364
119MP0009672_abnormal_birth_weight1.00083288
120MP0002060_abnormal_skin_morphology0.99870967
121MP0001502_abnormal_circadian_rhythm0.96908603
122MP0005380_embryogenesis_phenotype0.96769350
123MP0001672_abnormal_embryogenesis/_devel0.96769350
124MP0005397_hematopoietic_system_phenotyp0.96742974
125MP0001545_abnormal_hematopoietic_system0.96742974
126MP0005621_abnormal_cell_physiology0.95766679
127MP0004885_abnormal_endolymph0.94726033
128MP0003183_abnormal_peptide_metabolism0.93813781
129MP0004808_abnormal_hematopoietic_stem0.93270606
130MP0010307_abnormal_tumor_latency0.93227769
131MP0005394_taste/olfaction_phenotype0.93001431
132MP0005499_abnormal_olfactory_system0.93001431
133MP0002152_abnormal_brain_morphology0.92767879
134MP0002069_abnormal_eating/drinking_beha0.92565609
135MP0002098_abnormal_vibrissa_morphology0.92449179
136MP0004043_abnormal_pH_regulation0.92056470
137MP0002229_neurodegeneration0.91551003
138MP0001661_extended_life_span0.90995713
139MP0009053_abnormal_anal_canal0.90281694
140MP0002398_abnormal_bone_marrow0.88802140
141MP0003631_nervous_system_phenotype0.88157100
142MP0003984_embryonic_growth_retardation0.86605596
143MP0000467_abnormal_esophagus_morphology0.85798161
144MP0001697_abnormal_embryo_size0.85594488
145MP0002429_abnormal_blood_cell0.84705272
146MP0006036_abnormal_mitochondrial_physio0.84042449
147MP0005384_cellular_phenotype0.82508920
148MP0002722_abnormal_immune_system0.82321385
149MP0000778_abnormal_nervous_system0.81745084
150MP0006035_abnormal_mitochondrial_morpho0.81029270
151MP0010771_integument_phenotype0.80597477
152MP0000750_abnormal_muscle_regeneration0.80403899
153MP0005257_abnormal_intraocular_pressure0.80107908
154MP0001664_abnormal_digestion0.78088485
155MP0002088_abnormal_embryonic_growth/wei0.77721830
156MP0002086_abnormal_extraembryonic_tissu0.76387428
157MP0004233_abnormal_muscle_weight0.76338105
158MP0002085_abnormal_embryonic_tissue0.75346358
159MP0004215_abnormal_myocardial_fiber0.75285415
160MP0005025_abnormal_response_to0.74971104
161MP0002970_abnormal_white_adipose0.74392924
162MP0001963_abnormal_hearing_physiology0.74182412
163MP0000477_abnormal_intestine_morphology0.73477506
164MP0005535_abnormal_body_temperature0.71298263
165MP0005083_abnormal_biliary_tract0.71120721
166MP0004085_abnormal_heartbeat0.70956935
167MP0000759_abnormal_skeletal_muscle0.70953476
168MP0004782_abnormal_surfactant_physiolog0.70815249
169MP0008058_abnormal_DNA_repair0.70116821
170MP0003315_abnormal_perineum_morphology0.69693037
171MP0002751_abnormal_autonomic_nervous0.69555252
172MP0005670_abnormal_white_adipose0.69418552
173MP0003942_abnormal_urinary_system0.68851942
174MP0000631_abnormal_neuroendocrine_gland0.65541633
175MP0006292_abnormal_olfactory_placode0.62194466
176MP0002160_abnormal_reproductive_system0.62091907
177MP0008961_abnormal_basal_metabolism0.60430533
178MP0002752_abnormal_somatic_nervous0.59655637
179MP0000678_abnormal_parathyroid_gland0.59297384
180MP0008874_decreased_physiological_sensi0.58822444
181MP0003956_abnormal_body_size0.58034849
182MP0005551_abnormal_eye_electrophysiolog0.56624690
183MP0010769_abnormal_survival0.54796229
184MP0003634_abnormal_glial_cell0.54659277
185MP0004145_abnormal_muscle_electrophysio0.54607092
186MP0001177_atelectasis0.54542594
187MP0010768_mortality/aging0.53768176
188MP0000747_muscle_weakness0.52687582
189MP0003632_abnormal_nervous_system0.52343619
190MP0002082_postnatal_lethality0.52233604
191MP0010770_preweaning_lethality0.52233604
192MP0003075_altered_response_to0.50964247
193MP0000358_abnormal_cell_content/0.49128096
194MP0002873_normal_phenotype0.48069046

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.39081514
2Myokymia (HP:0002411)6.85083692
3Visual hallucinations (HP:0002367)5.59674713
4Atonic seizures (HP:0010819)5.41987325
5Epileptic encephalopathy (HP:0200134)4.91017279
6Focal seizures (HP:0007359)4.80318571
7Febrile seizures (HP:0002373)4.40771360
8Absence seizures (HP:0002121)4.32660417
9Dialeptic seizures (HP:0011146)3.87977778
10Ragged-red muscle fibers (HP:0003200)3.68349784
11Cutaneous melanoma (HP:0012056)3.52510592
12Generalized tonic-clonic seizures (HP:0002069)3.50726741
13Ankle clonus (HP:0011448)3.30909796
14Progressive cerebellar ataxia (HP:0002073)3.22873465
15Broad distal phalanx of finger (HP:0009836)3.21778443
16Impaired vibration sensation in the lower limbs (HP:0002166)3.16521255
17Hyperacusis (HP:0010780)3.15674900
18Microvesicular hepatic steatosis (HP:0001414)3.01351267
19Depression (HP:0000716)2.99679871
20Achilles tendon contracture (HP:0001771)2.95582466
21Truncal ataxia (HP:0002078)2.89553637
22Abnormal mitochondria in muscle tissue (HP:0008316)2.89168344
23Vertebral compression fractures (HP:0002953)2.85535643
24Progressive muscle weakness (HP:0003323)2.84719449
25Acute necrotizing encephalopathy (HP:0006965)2.82335502
26Unsteady gait (HP:0002317)2.77539132
27Pheochromocytoma (HP:0002666)2.76690423
28Annular pancreas (HP:0001734)2.76381633
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76131423
30Ulnar bowing (HP:0003031)2.74022657
31Trismus (HP:0000211)2.73883459
32Delusions (HP:0000746)2.70617578
33Abnormality of the lower motor neuron (HP:0002366)2.69880789
34Abnormal eating behavior (HP:0100738)2.67784996
35Hepatocellular necrosis (HP:0001404)2.66055421
36Anxiety (HP:0000739)2.64906065
37Cerebral hypomyelination (HP:0006808)2.64161557
38Gaze-evoked nystagmus (HP:0000640)2.64115100
39Poor suck (HP:0002033)2.62385631
40Mitochondrial inheritance (HP:0001427)2.58969605
41Failure to thrive in infancy (HP:0001531)2.58070111
42Multiple enchondromatosis (HP:0005701)2.56125768
43Hyperventilation (HP:0002883)2.55358400
44Poor eye contact (HP:0000817)2.54369891
45Abnormality of the Achilles tendon (HP:0005109)2.50086757
46Neuroendocrine neoplasm (HP:0100634)2.49605305
47Broad-based gait (HP:0002136)2.49358160
48Abnormality of the umbilical cord (HP:0010881)2.49142378
49Epileptiform EEG discharges (HP:0011182)2.48722752
50Impaired smooth pursuit (HP:0007772)2.48317308
51Selective tooth agenesis (HP:0001592)2.47870839
52Rough bone trabeculation (HP:0100670)2.47603630
53Testicular atrophy (HP:0000029)2.44586535
54Stridor (HP:0010307)2.44373060
55Abnormal hair whorl (HP:0010721)2.40113170
56Impaired social interactions (HP:0000735)2.37094880
57Abnormal social behavior (HP:0012433)2.37094880
58Microretrognathia (HP:0000308)2.36789781
59Emotional lability (HP:0000712)2.36579429
60Long palpebral fissure (HP:0000637)2.36413047
61Premature skin wrinkling (HP:0100678)2.35361029
62Focal dystonia (HP:0004373)2.34763174
63Gait imbalance (HP:0002141)2.33702724
64Dysmetria (HP:0001310)2.32962349
65Increased CSF lactate (HP:0002490)2.32691107
66Neoplasm of the peripheral nervous system (HP:0100007)2.32525527
67Amblyopia (HP:0000646)2.31256335
68EEG with generalized epileptiform discharges (HP:0011198)2.28314705
69Dysdiadochokinesis (HP:0002075)2.26277008
70Distal lower limb muscle weakness (HP:0009053)2.25770970
71Abnormality of the labia minora (HP:0012880)2.25024973
72Cortical visual impairment (HP:0100704)2.24335214
73Hypokinesia (HP:0002375)2.23682269
74Supranuclear gaze palsy (HP:0000605)2.23674411
75Progressive macrocephaly (HP:0004481)2.23350918
76Spinal canal stenosis (HP:0003416)2.23185030
77J-shaped sella turcica (HP:0002680)2.22746839
78Squamous cell carcinoma (HP:0002860)2.22248943
79Abnormality of ocular smooth pursuit (HP:0000617)2.21413567
80Generalized amyotrophy (HP:0003700)2.21056242
81Abnormality of the distal phalanges of the toes (HP:0010182)2.21004046
82Action tremor (HP:0002345)2.20275713
83Hypertensive crisis (HP:0100735)2.19638651
84Oligomenorrhea (HP:0000876)2.19201126
85Abnormality of the fetal cardiovascular system (HP:0010948)2.17680240
86Abnormal umbilical cord blood vessels (HP:0011403)2.17680240
87Single umbilical artery (HP:0001195)2.17680240
88Congenital primary aphakia (HP:0007707)2.17460503
89Hypsarrhythmia (HP:0002521)2.15844659
90Hemiplegia (HP:0002301)2.15281875
91Distal lower limb amyotrophy (HP:0008944)2.15060623
92Cellulitis (HP:0100658)2.14101319
93Thin bony cortex (HP:0002753)2.12980746
94Neuroblastic tumors (HP:0004376)2.12819063
95Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.12819063
96Neuroblastoma (HP:0003006)2.12819063
97Primitive neuroectodermal tumor (HP:0030065)2.12819063
98Bradykinesia (HP:0002067)2.12535513
99Menstrual irregularities (HP:0000858)2.11275879
100Cholecystitis (HP:0001082)2.11250630
101Abnormal gallbladder physiology (HP:0012438)2.11250630
102Deep palmar crease (HP:0006191)2.10845240
103Limb dystonia (HP:0002451)2.10568166
104Torticollis (HP:0000473)2.10404853
105Insomnia (HP:0100785)2.09618252
106Resting tremor (HP:0002322)2.07575668
107Nephrogenic diabetes insipidus (HP:0009806)2.07487319
108Asymmetry of the thorax (HP:0001555)2.06573806
109Broad face (HP:0000283)2.05846533
110Distal upper limb amyotrophy (HP:0007149)2.03323171
111Upper limb amyotrophy (HP:0009129)2.03323171
112Abnormality of pain sensation (HP:0010832)2.02981118
113Impaired pain sensation (HP:0007328)2.02981118
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02710674
115Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02710674
116Myopathic facies (HP:0002058)2.02675165
117Hemiparesis (HP:0001269)2.02350788
118Micronodular cirrhosis (HP:0001413)2.01544058
119Hepatic necrosis (HP:0002605)2.00793553
120Diplopia (HP:0000651)2.00782944
121Abnormality of binocular vision (HP:0011514)2.00782944
122Urinary bladder sphincter dysfunction (HP:0002839)2.00666116
123Elbow flexion contracture (HP:0002987)2.00176109
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.99640869
125Medial flaring of the eyebrow (HP:0010747)1.99377044
126Abnormality of the thoracic spine (HP:0100711)1.98014942
127Increased cerebral lipofuscin (HP:0011813)1.97897176
128Poikiloderma (HP:0001029)1.97603294
129Acute encephalopathy (HP:0006846)1.97211791
130Abnormal trabecular bone morphology (HP:0100671)1.96757527
131Craniofacial dystonia (HP:0012179)1.95698966
132Hypoventilation (HP:0002791)1.93360531
133Bulbar palsy (HP:0001283)1.93254499
134Biconcave vertebral bodies (HP:0004586)1.90804586
135Hyperthyroidism (HP:0000836)1.87795556
136Abnormal number of erythroid precursors (HP:0012131)1.87212106
137Increased muscle lipid content (HP:0009058)1.87115294
138Abnormality of cells of the erythroid lineage (HP:0012130)1.86801743
139Spinal cord compression (HP:0002176)1.86497028
140Premature rupture of membranes (HP:0001788)1.85736030
141Breast hypoplasia (HP:0003187)1.85467931
142Truncus arteriosus (HP:0001660)1.84461199
143Increased serum ferritin (HP:0003281)1.83999869
144Polyphagia (HP:0002591)1.83636709
145Urinary urgency (HP:0000012)1.83431416
146Short nail (HP:0001799)1.83174814
147Impaired vibratory sensation (HP:0002495)1.83074465
148Limb ataxia (HP:0002070)1.81931561
149Spastic gait (HP:0002064)1.81622526
150Ventricular fibrillation (HP:0001663)1.81222150
151Lymphangioma (HP:0100764)1.80658232
152Entropion (HP:0000621)1.79662297
153Stereotypic behavior (HP:0000733)1.79618781
154Generalized hypotonia (HP:0001290)1.79500359
155Disproportionate tall stature (HP:0001519)1.78766875
156Nonimmune hydrops fetalis (HP:0001790)1.78643720
157Pointed chin (HP:0000307)1.77483669
158Specific learning disability (HP:0001328)1.77350771
159Centrally nucleated skeletal muscle fibers (HP:0003687)1.76841599
160Postnatal microcephaly (HP:0005484)1.76838795
161Gait ataxia (HP:0002066)1.76582816
162Protruding tongue (HP:0010808)1.75823289
163Reticulocytosis (HP:0001923)1.75033925
164Recurrent viral infections (HP:0004429)1.74975273
165Incomplete penetrance (HP:0003829)1.74938022
166Patellar dislocation (HP:0002999)1.74912571
167Dysmetric saccades (HP:0000641)1.74525498
168Generalized myoclonic seizures (HP:0002123)1.73304825
169Increased connective tissue (HP:0009025)1.72937834
170Mutism (HP:0002300)1.72620018
171Fetal akinesia sequence (HP:0001989)1.72087131
172Easy fatigability (HP:0003388)1.71594587
173Postural instability (HP:0002172)1.71412326
174Fragile skin (HP:0001030)1.70575835
175Polygenic inheritance (HP:0010982)1.69501629
176Dysostosis multiplex (HP:0000943)1.69373789
177Septate vagina (HP:0001153)1.69134396
178Colitis (HP:0002583)1.68914665
179Increased intramyocellular lipid droplets (HP:0012240)1.67249579
180Prolonged neonatal jaundice (HP:0006579)1.67197495
181Seborrheic dermatitis (HP:0001051)1.66146365
182Petechiae (HP:0000967)1.65774131
183Obstructive lung disease (HP:0006536)1.65514147
184Chronic obstructive pulmonary disease (HP:0006510)1.65514147
185Viral hepatitis (HP:0006562)1.64907361
186Abnormality of the tricuspid valve (HP:0001702)1.64505740
187Abdominal distention (HP:0003270)1.63996276
188Thoracic kyphosis (HP:0002942)1.62960860
189Joint stiffness (HP:0001387)1.62925672
190Hepatosplenomegaly (HP:0001433)1.61467812
191Abnormality of reticulocytes (HP:0004312)1.61220875
192Hyperparathyroidism (HP:0000843)1.61168348
193Congenital glaucoma (HP:0001087)1.61069153
194Short clavicles (HP:0000894)1.59905465
195Abnormalities of placenta or umbilical cord (HP:0001194)1.59517882
196Pili torti (HP:0003777)1.58230935
197Genu recurvatum (HP:0002816)1.56841176
198Bowed forearm bones (HP:0003956)1.55271626
199Bowing of the arm (HP:0006488)1.55271626
200Spinal cord lesions (HP:0100561)1.54323019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.77868015
2NME24.67533609
3NTRK34.31409745
4SMG13.97901510
5IRAK33.38330484
6EPHA43.28228055
7MAP3K93.28190777
8MAP3K123.22488016
9ARAF3.09356003
10DAPK12.81574602
11SIK12.75198245
12MAP2K72.62447824
13CASK2.62174326
14MINK12.48149120
15MAP3K42.43227591
16VRK22.40610595
17DAPK22.34494395
18PRPF4B2.24206765
19KSR22.23868442
20ERN12.18868300
21CDK192.18451638
22ICK2.13036376
23MAP3K112.06285601
24BRAF2.04180377
25CCNB12.02907782
26EEF2K2.01327745
27TESK11.90132509
28EPHA21.88743682
29TSSK61.78575411
30AKT31.78410523
31MAP2K31.70206482
32NME11.70012299
33MAP3K101.69615264
34PRKD31.66256209
35PLK21.62844023
36GRK51.59974257
37PKN21.54143910
38NEK11.53651300
39PIM21.50678223
40PAK61.48809743
41KDR1.45373794
42PAK41.44738838
43CAMKK11.43326386
44MAP3K131.40272592
45MARK11.38898208
46BUB11.37006933
47NTRK11.35420733
48CDK51.33565276
49CDK121.27474855
50RIPK41.25906837
51PRKCG1.24870616
52MAP2K41.22831281
53RPS6KB21.21039334
54CDK181.18262042
55KSR11.16370588
56STK161.15859129
57MST1R1.15836557
58CAMKK21.14889183
59IRAK21.14873397
60RAF11.14552540
61TNIK1.12125391
62CDK151.11588382
63CDK141.09160985
64BRSK11.09017730
65CDK71.06153269
66IRAK41.05562979
67MAPK131.05130611
68MAP4K11.04746972
69SCYL21.04647559
70TAOK11.04103019
71BCKDK1.04003260
72UHMK11.03322306
73ILK1.02989866
74MAP3K21.02683031
75CDK11A1.01045550
76MAP3K31.00734951
77CDK81.00235790
78SIK30.99863193
79NTRK20.98368987
80TTN0.98033011
81TBK10.97470378
82MAP3K80.92700131
83ABL20.89785065
84LRRK20.88550635
85PRKD20.87115533
86CDK40.85175708
87MUSK0.84225191
88PASK0.83517270
89MAP2K20.82860636
90FES0.81852825
91PBK0.81565321
92GRK60.81416499
93PTK60.81124859
94RIPK10.78841405
95MTOR0.78262067
96STK380.76863179
97PTK2B0.76131198
98SGK2230.74935390
99SGK4940.74935390
100DAPK30.73187316
101PDPK10.71538196
102MAPK110.70684720
103CHEK20.69421683
104CAMK2A0.69334386
105TNK20.68080515
106RPS6KL10.66693771
107RPS6KC10.66693771
108CAMK2B0.66249965
109EIF2AK10.65395806
110PTK20.65081564
111PDK40.65076994
112PDK30.65076994
113MAP3K140.64786261
114BMPR20.64018784
115LMTK20.61910849
116MAPKAPK30.61690530
117SGK20.60951591
118BMX0.59518940
119PINK10.58295423
120LATS20.58261771
121MAP2K10.57902308
122MAP3K10.57747392
123PLK30.55982593
124CAMK10.55846829
125WEE10.55462984
126FGFR40.55320547
127ALK0.55288088
128RPS6KA20.53507730
129PNCK0.52856496
130PRKCH0.51136697
131RPS6KA40.50448953
132EIF2AK30.50151157
133AKT20.47594249
134CDC70.47239388
135DYRK1A0.46479006
136IKBKB0.46446298
137MAP3K60.46370740
138ATR0.46254921
139RET0.45516775
140SIK20.45450069
141RPS6KA60.45058091
142TYK20.43497054
143PRKG20.43066993
144AURKA0.43005514
145SRPK10.41893376
146CHEK10.41756595
147VRK10.41588148
148MARK20.40368757
149MAPKAPK50.40030966
150TAOK20.39920061
151SGK30.39796602
152MAPKAPK20.39309531
153AURKB0.39122673
154CAMK2D0.38592719
155CDK90.37573666
156STK40.36923048
157TESK20.36743525
158MYLK0.36388980
159CAMK2G0.35702999
160PDK10.35033434
161RPS6KA10.34926774
162STK100.31944317
163HIPK20.31745549
164TLK10.30285513
165TTK0.29985419
166PRKCE0.29538521
167PRKCI0.29347988
168LIMK10.29294178
169MAPK100.27825918
170MOS0.27778321
171SGK10.27079263
172CHUK0.25862855
173PAK10.25817446

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.27399727
2Sulfur relay system_Homo sapiens_hsa041223.76055138
3Nicotine addiction_Homo sapiens_hsa050333.20692491
4Olfactory transduction_Homo sapiens_hsa047402.92281511
5Collecting duct acid secretion_Homo sapiens_hsa049662.62923689
6Long-term potentiation_Homo sapiens_hsa047202.60952031
7Circadian entrainment_Homo sapiens_hsa047132.60524673
8GABAergic synapse_Homo sapiens_hsa047272.60053514
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55546778
10Ribosome_Homo sapiens_hsa030102.44384495
11Amphetamine addiction_Homo sapiens_hsa050312.42462061
12Morphine addiction_Homo sapiens_hsa050322.42168732
13Insulin secretion_Homo sapiens_hsa049112.13991951
14Glutamatergic synapse_Homo sapiens_hsa047242.13121805
15Other glycan degradation_Homo sapiens_hsa005112.08093451
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05422586
17Dopaminergic synapse_Homo sapiens_hsa047282.03702691
18Vibrio cholerae infection_Homo sapiens_hsa051102.00634633
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97911513
20Pentose phosphate pathway_Homo sapiens_hsa000301.96658675
21Bladder cancer_Homo sapiens_hsa052191.91111315
22Acute myeloid leukemia_Homo sapiens_hsa052211.79232176
23Oxidative phosphorylation_Homo sapiens_hsa001901.73813067
24Chronic myeloid leukemia_Homo sapiens_hsa052201.68631344
25Salivary secretion_Homo sapiens_hsa049701.67778062
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.64681489
27Taste transduction_Homo sapiens_hsa047421.64386209
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62429763
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61244379
30Cholinergic synapse_Homo sapiens_hsa047251.58586335
31Parkinsons disease_Homo sapiens_hsa050121.51447328
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50085613
33Proteasome_Homo sapiens_hsa030501.47705919
34Galactose metabolism_Homo sapiens_hsa000521.45957862
35Serotonergic synapse_Homo sapiens_hsa047261.45752568
36Cocaine addiction_Homo sapiens_hsa050301.40713339
37Gastric acid secretion_Homo sapiens_hsa049711.40219966
38Oocyte meiosis_Homo sapiens_hsa041141.35461683
39Calcium signaling pathway_Homo sapiens_hsa040201.32856788
40Notch signaling pathway_Homo sapiens_hsa043301.30977797
41Oxytocin signaling pathway_Homo sapiens_hsa049211.30318157
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.29464195
43Long-term depression_Homo sapiens_hsa047301.28173054
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27452206
45Vitamin B6 metabolism_Homo sapiens_hsa007501.23475202
46Alzheimers disease_Homo sapiens_hsa050101.21180292
47Pancreatic cancer_Homo sapiens_hsa052121.21069165
48Shigellosis_Homo sapiens_hsa051311.19910590
49Gap junction_Homo sapiens_hsa045401.19363570
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16735588
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16444916
52Renin secretion_Homo sapiens_hsa049241.15901380
53B cell receptor signaling pathway_Homo sapiens_hsa046621.14654764
54Cell cycle_Homo sapiens_hsa041101.12623287
55Cardiac muscle contraction_Homo sapiens_hsa042601.10312454
56GnRH signaling pathway_Homo sapiens_hsa049121.09388202
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08975055
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.08300734
59Carbon metabolism_Homo sapiens_hsa012001.07098854
60Huntingtons disease_Homo sapiens_hsa050161.04870091
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02616816
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01208606
63Apoptosis_Homo sapiens_hsa042100.97941608
64Epstein-Barr virus infection_Homo sapiens_hsa051690.97824342
65DNA replication_Homo sapiens_hsa030300.96716868
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94829858
67Glioma_Homo sapiens_hsa052140.93974608
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92345517
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89548085
70HTLV-I infection_Homo sapiens_hsa051660.89544948
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88642752
72cAMP signaling pathway_Homo sapiens_hsa040240.87197112
73Hepatitis B_Homo sapiens_hsa051610.84955640
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84351023
75RNA polymerase_Homo sapiens_hsa030200.83998209
76Mismatch repair_Homo sapiens_hsa034300.83614879
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83568397
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83480911
79Estrogen signaling pathway_Homo sapiens_hsa049150.83375681
80Viral carcinogenesis_Homo sapiens_hsa052030.82348179
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82122606
82ErbB signaling pathway_Homo sapiens_hsa040120.81071372
83mRNA surveillance pathway_Homo sapiens_hsa030150.81019629
84Small cell lung cancer_Homo sapiens_hsa052220.80803711
85Type II diabetes mellitus_Homo sapiens_hsa049300.78283203
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77510440
87Folate biosynthesis_Homo sapiens_hsa007900.77382137
88Sulfur metabolism_Homo sapiens_hsa009200.77145410
89Type I diabetes mellitus_Homo sapiens_hsa049400.76824738
90Hepatitis C_Homo sapiens_hsa051600.74851204
91Alcoholism_Homo sapiens_hsa050340.73932964
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.73846918
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73820146
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73633756
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73202555
96Herpes simplex infection_Homo sapiens_hsa051680.71357482
97Lysosome_Homo sapiens_hsa041420.71231646
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69728792
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69135913
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69024495
101Glutathione metabolism_Homo sapiens_hsa004800.68697718
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68391890
103Melanogenesis_Homo sapiens_hsa049160.67698926
104p53 signaling pathway_Homo sapiens_hsa041150.67200615
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66825030
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66707053
107Prion diseases_Homo sapiens_hsa050200.66169386
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65398797
109Purine metabolism_Homo sapiens_hsa002300.65170982
110Homologous recombination_Homo sapiens_hsa034400.63871822
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62195190
112Pancreatic secretion_Homo sapiens_hsa049720.61746221
113Salmonella infection_Homo sapiens_hsa051320.61505474
114AMPK signaling pathway_Homo sapiens_hsa041520.60638975
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59786927
116Primary immunodeficiency_Homo sapiens_hsa053400.58502840
117One carbon pool by folate_Homo sapiens_hsa006700.57530581
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.56651046
119Fanconi anemia pathway_Homo sapiens_hsa034600.55563322
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53999053
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.53995493
122Influenza A_Homo sapiens_hsa051640.53856053
123Renal cell carcinoma_Homo sapiens_hsa052110.53702847
124Non-homologous end-joining_Homo sapiens_hsa034500.51912456
125Thyroid hormone synthesis_Homo sapiens_hsa049180.50886460
126Osteoclast differentiation_Homo sapiens_hsa043800.50790233
127Thyroid cancer_Homo sapiens_hsa052160.50782353
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.49330777
129Prostate cancer_Homo sapiens_hsa052150.48972579
130Non-small cell lung cancer_Homo sapiens_hsa052230.48500167
131MAPK signaling pathway_Homo sapiens_hsa040100.48483970
132TNF signaling pathway_Homo sapiens_hsa046680.47574430
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.46997262
134Rheumatoid arthritis_Homo sapiens_hsa053230.46948236
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46530012
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.45729110
137N-Glycan biosynthesis_Homo sapiens_hsa005100.45374948
138Base excision repair_Homo sapiens_hsa034100.43324828
139Fatty acid elongation_Homo sapiens_hsa000620.42626740
140Phototransduction_Homo sapiens_hsa047440.42331961
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41529157
142MicroRNAs in cancer_Homo sapiens_hsa052060.40909447
143Pyrimidine metabolism_Homo sapiens_hsa002400.40493977
144Toxoplasmosis_Homo sapiens_hsa051450.39971177
145Regulation of autophagy_Homo sapiens_hsa041400.39401227
146Proteoglycans in cancer_Homo sapiens_hsa052050.39364422
147Endocytosis_Homo sapiens_hsa041440.38296598
148RNA transport_Homo sapiens_hsa030130.38163682
149VEGF signaling pathway_Homo sapiens_hsa043700.37701554
150Glucagon signaling pathway_Homo sapiens_hsa049220.37659904
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37625151
152Dilated cardiomyopathy_Homo sapiens_hsa054140.37486492
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37327609
154Fructose and mannose metabolism_Homo sapiens_hsa000510.35684612
155Ras signaling pathway_Homo sapiens_hsa040140.34603528
156mTOR signaling pathway_Homo sapiens_hsa041500.32048597
157Spliceosome_Homo sapiens_hsa030400.31941370
158Nucleotide excision repair_Homo sapiens_hsa034200.31823772
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.29196840
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28493633
161Axon guidance_Homo sapiens_hsa043600.27005845
162Insulin signaling pathway_Homo sapiens_hsa049100.26917752
163Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26573633
164Phagosome_Homo sapiens_hsa041450.26142796
165Colorectal cancer_Homo sapiens_hsa052100.25610257
166Endometrial cancer_Homo sapiens_hsa052130.24707596
167Biosynthesis of amino acids_Homo sapiens_hsa012300.23465425

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