RPUSD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.30084878
2doxorubicin metabolic process (GO:0044598)7.30084878
3daunorubicin metabolic process (GO:0044597)7.30084878
4protein localization to kinetochore (GO:0034501)5.95285447
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.48042957
6DNA replication checkpoint (GO:0000076)4.96713803
7DNA replication-dependent nucleosome assembly (GO:0006335)4.86338102
8DNA replication-dependent nucleosome organization (GO:0034723)4.86338102
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.82755558
10mitotic sister chromatid segregation (GO:0000070)4.77586506
11nuclear pore complex assembly (GO:0051292)4.77252003
12protein localization to chromosome, centromeric region (GO:0071459)4.68449882
13histone H4-K12 acetylation (GO:0043983)4.67493639
14negative regulation of epidermis development (GO:0045683)4.62950271
15rRNA transcription (GO:0009303)4.59827126
16aminoglycoside antibiotic metabolic process (GO:0030647)4.56767095
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.56008374
18nuclear pore organization (GO:0006999)4.52843897
19rRNA modification (GO:0000154)4.45325106
20regulation of telomere maintenance via telomerase (GO:0032210)4.40451945
21ribosome biogenesis (GO:0042254)4.39726114
22maintenance of protein location in nucleus (GO:0051457)4.38656921
23negative regulation of cell cycle G2/M phase transition (GO:1902750)4.28487332
24rRNA methylation (GO:0031167)4.26987845
25DNA replication initiation (GO:0006270)4.22600036
26DNA unwinding involved in DNA replication (GO:0006268)4.20571779
27heterochromatin organization (GO:0070828)4.20350943
28sister chromatid segregation (GO:0000819)4.09718638
29formation of translation preinitiation complex (GO:0001731)4.09544972
30negative regulation of telomerase activity (GO:0051974)4.08535918
31regulation of mitochondrial translation (GO:0070129)4.06648762
32histone H4-K5 acetylation (GO:0043981)4.04006906
33histone H4-K8 acetylation (GO:0043982)4.04006906
34somite rostral/caudal axis specification (GO:0032525)4.00515749
35negative regulation of epidermal cell differentiation (GO:0045605)3.97518395
36regulation of translation in response to stress (GO:0043555)3.97378089
37positive regulation of DNA-dependent DNA replication (GO:2000105)3.91909240
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.86126840
39pore complex assembly (GO:0046931)3.83777065
40ribonucleoprotein complex biogenesis (GO:0022613)3.83421227
41chromatin assembly (GO:0031497)3.83163311
42DNA damage response, detection of DNA damage (GO:0042769)3.77752688
43proteasome assembly (GO:0043248)3.73006800
44spliceosomal snRNP assembly (GO:0000387)3.71439631
45regulation of response to osmotic stress (GO:0047484)3.69927560
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68233400
47ribosomal small subunit biogenesis (GO:0042274)3.66537784
48establishment of integrated proviral latency (GO:0075713)3.64995133
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.61716081
50negative regulation of telomere maintenance (GO:0032205)3.61623135
51cullin deneddylation (GO:0010388)3.59626297
52DNA duplex unwinding (GO:0032508)3.57772977
53regulation of gene silencing by RNA (GO:0060966)3.54953340
54regulation of posttranscriptional gene silencing (GO:0060147)3.54953340
55regulation of gene silencing by miRNA (GO:0060964)3.54953340
56mitochondrial RNA metabolic process (GO:0000959)3.53901859
57DNA geometric change (GO:0032392)3.53394946
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52826089
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51179701
60mitotic chromosome condensation (GO:0007076)3.48524053
61ribosome assembly (GO:0042255)3.45970055
62telomere maintenance via recombination (GO:0000722)3.45402907
63DNA catabolic process, exonucleolytic (GO:0000738)3.43633123
64regulation of MHC class I biosynthetic process (GO:0045343)3.43364856
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.41147200
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40743024
67negative regulation of ligase activity (GO:0051352)3.38523084
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38523084
69ribosomal small subunit assembly (GO:0000028)3.37949330
70IMP biosynthetic process (GO:0006188)3.36028889
71DNA strand elongation involved in DNA replication (GO:0006271)3.34927232
72negative regulation of mRNA processing (GO:0050686)3.34728122
73regulation of double-strand break repair (GO:2000779)3.33501304
74chaperone-mediated protein transport (GO:0072321)3.33166066
75interferon-gamma production (GO:0032609)3.32246617
76muscle organ morphogenesis (GO:0048644)3.31812485
77DNA double-strand break processing (GO:0000729)3.30189196
78mitotic metaphase plate congression (GO:0007080)3.29941034
79nucleobase biosynthetic process (GO:0046112)3.29296091
80protein deneddylation (GO:0000338)3.28338534
81mitotic nuclear envelope disassembly (GO:0007077)3.27746690
82tRNA methylation (GO:0030488)3.27265945
83establishment of viral latency (GO:0019043)3.23672096
84transcription elongation from RNA polymerase III promoter (GO:0006385)3.21907082
85termination of RNA polymerase III transcription (GO:0006386)3.21907082
86negative regulation of RNA splicing (GO:0033119)3.20502709
87viral mRNA export from host cell nucleus (GO:0046784)3.19895354
88DNA strand elongation (GO:0022616)3.19124728
89maturation of 5.8S rRNA (GO:0000460)3.18835454
90telomere maintenance via semi-conservative replication (GO:0032201)3.18384063
91peptidyl-arginine omega-N-methylation (GO:0035247)3.18189488
92notochord development (GO:0030903)3.17245634
93pre-miRNA processing (GO:0031054)3.16971701
94* pseudouridine synthesis (GO:0001522)3.16919490
95protein targeting to mitochondrion (GO:0006626)3.15739155
96purine nucleobase biosynthetic process (GO:0009113)3.11422169
97telomere maintenance via telomere lengthening (GO:0010833)3.11175300
98transcription from mitochondrial promoter (GO:0006390)3.10875289
99regulation of cilium movement (GO:0003352)3.08827145
100mitochondrial DNA replication (GO:0006264)3.08461962
101histone arginine methylation (GO:0034969)3.07790247
102chromatin assembly or disassembly (GO:0006333)3.07725723
103ribosomal large subunit biogenesis (GO:0042273)3.06873466
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06644973
105termination of RNA polymerase II transcription (GO:0006369)3.06271230
106DNA ligation (GO:0006266)3.04866255
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01825200
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00880172
109regulation of DNA-dependent DNA replication (GO:0090329)2.98635946
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.97986100
111histone H4-K16 acetylation (GO:0043984)2.97980255
112nuclear envelope disassembly (GO:0051081)2.97632310
113membrane disassembly (GO:0030397)2.97632310
114rRNA processing (GO:0006364)2.97465196
115ncRNA processing (GO:0034470)2.97243928
116positive regulation of ligase activity (GO:0051351)2.96980471
117kinetochore organization (GO:0051383)2.96618541
118chromatin remodeling at centromere (GO:0031055)2.96257471
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95866101
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.95866101
121iron-sulfur cluster assembly (GO:0016226)2.95564425
122metallo-sulfur cluster assembly (GO:0031163)2.95564425
123CENP-A containing nucleosome assembly (GO:0034080)2.94218126
124base-excision repair (GO:0006284)2.94122188
125mitotic G2/M transition checkpoint (GO:0044818)2.93865472
126ncRNA metabolic process (GO:0034660)2.93342991
127negative regulation of chromosome segregation (GO:0051985)2.93300780
128negative regulation of mRNA metabolic process (GO:1903312)2.92511633
129regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92145934
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.92071989
131negative regulation of sister chromatid segregation (GO:0033046)2.92071989
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92071989
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92071989
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92071989
135establishment of protein localization to mitochondrion (GO:0072655)2.91316200
136cellular component biogenesis (GO:0044085)2.91186671
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.90312435
138DNA replication-independent nucleosome assembly (GO:0006336)2.89190420
139DNA replication-independent nucleosome organization (GO:0034724)2.89190420
140mRNA stabilization (GO:0048255)2.89025186
141RNA stabilization (GO:0043489)2.89025186
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88608352
143transcription-coupled nucleotide-excision repair (GO:0006283)2.87720057
144rRNA metabolic process (GO:0016072)2.87353268
145translational termination (GO:0006415)2.87118612
146folic acid-containing compound biosynthetic process (GO:0009396)2.87024000
147viral transcription (GO:0019083)2.86961155
148quinone metabolic process (GO:1901661)2.86882911
149mitotic recombination (GO:0006312)2.86274105
150DNA conformation change (GO:0071103)2.86139375
151mitotic spindle checkpoint (GO:0071174)2.86126778
152pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85408308
153regulation of apoptotic process involved in morphogenesis (GO:1902337)2.84151925
154regulation of telomere maintenance (GO:0032204)2.83216943
155metaphase plate congression (GO:0051310)2.82195374
156IMP metabolic process (GO:0046040)2.82040344
157regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81538530
158maturation of SSU-rRNA (GO:0030490)2.81390232
159attachment of spindle microtubules to kinetochore (GO:0008608)2.80638114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20876453
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.95612571
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.95612571
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.95612571
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.84899773
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.73646555
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70710695
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.53751231
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.12076090
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84155046
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76501954
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.74479862
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73529564
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66405026
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65332647
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60600394
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42441975
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.40550146
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.27835870
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26472674
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.21343435
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.19662202
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12837222
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08333814
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.03627356
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97992659
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96624443
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96519170
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.94843847
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88065356
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84870388
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.82948872
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.82647258
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82064734
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81121977
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78560586
37FOXP3_21729870_ChIP-Seq_TREG_Human1.75612892
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74877336
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72719894
40XRN2_22483619_ChIP-Seq_HELA_Human1.68158788
41* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67798091
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64174218
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63728226
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62569767
45* VDR_23849224_ChIP-Seq_CD4+_Human1.62248153
46IRF1_19129219_ChIP-ChIP_H3396_Human1.62172979
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61723787
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56480066
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.54225024
50MYC_22102868_ChIP-Seq_BL_Human1.54072072
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52050866
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49695858
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48485549
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47779389
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47766172
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46960722
57TTF2_22483619_ChIP-Seq_HELA_Human1.43617682
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43030725
59AR_21909140_ChIP-Seq_LNCAP_Human1.42345472
60GABP_19822575_ChIP-Seq_HepG2_Human1.41383762
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40631672
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38871537
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38350036
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38174956
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37653490
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.37004687
67MYC_18940864_ChIP-ChIP_HL60_Human1.35192198
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34742763
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32665237
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31189910
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29536769
72DCP1A_22483619_ChIP-Seq_HELA_Human1.26311137
73* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26052478
74KDM5A_27292631_Chip-Seq_BREAST_Human1.25225617
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23902491
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22861533
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22313390
78CIITA_25753668_ChIP-Seq_RAJI_Human1.21487263
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19645025
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19551658
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18545939
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18258047
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17132280
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16189282
85POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14047233
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12875830
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12274953
88ELK1_19687146_ChIP-ChIP_HELA_Human1.12139595
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10748605
90VDR_21846776_ChIP-Seq_THP-1_Human1.10138969
91* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07848317
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07744662
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.07061442
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06091897
95* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05449300
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05096722
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04883065
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04796388
99POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04193850
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03484474
101SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01270681
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01123679
103SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99675746
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98880598
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98197040
106NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98104172
107TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97055679
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96497566
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96378076
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.94655338
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93642163
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93264450
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92951840
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91600384
115EGR1_19374776_ChIP-ChIP_THP-1_Human0.91235206
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.90045024
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89772067
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89219138
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89208225
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88479687
121TFEB_21752829_ChIP-Seq_HELA_Human0.88191312
122* SRF_21415370_ChIP-Seq_HL-1_Mouse0.85286637
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84104784
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83044321
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82529567
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82524134
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82204670
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82124437
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81377966
130ZNF263_19887448_ChIP-Seq_K562_Human0.80598287
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80282846
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.79830506
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73511546
134* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73242952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.38141554
2MP0004957_abnormal_blastocyst_morpholog4.11031806
3MP0006292_abnormal_olfactory_placode4.06594182
4MP0003011_delayed_dark_adaptation3.26504232
5MP0003693_abnormal_embryo_hatching3.23929073
6MP0010094_abnormal_chromosome_stability3.22651525
7MP0003890_abnormal_embryonic-extraembry3.11407526
8MP0003111_abnormal_nucleus_morphology3.03391825
9MP0003077_abnormal_cell_cycle3.01677023
10MP0005075_abnormal_melanosome_morpholog2.73287187
11MP0004264_abnormal_extraembryonic_tissu2.65194356
12MP0005394_taste/olfaction_phenotype2.62668757
13MP0005499_abnormal_olfactory_system2.62668757
14MP0010352_gastrointestinal_tract_polyps2.32783403
15MP0003121_genomic_imprinting2.30734332
16MP0008058_abnormal_DNA_repair2.27498004
17MP0003123_paternal_imprinting2.24255600
18MP0002396_abnormal_hematopoietic_system2.14445309
19MP0002254_reproductive_system_inflammat2.09227950
20MP0000350_abnormal_cell_proliferation2.07431898
21MP0001672_abnormal_embryogenesis/_devel2.05449987
22MP0005380_embryogenesis_phenotype2.05449987
23MP0005451_abnormal_body_composition2.02901639
24MP0008932_abnormal_embryonic_tissue2.01450737
25MP0008007_abnormal_cellular_replicative2.01331705
26MP0003122_maternal_imprinting1.95081980
27MP0006035_abnormal_mitochondrial_morpho1.90209105
28MP0001346_abnormal_lacrimal_gland1.88442659
29MP0002088_abnormal_embryonic_growth/wei1.84698856
30MP0003984_embryonic_growth_retardation1.84488781
31MP0010030_abnormal_orbit_morphology1.81027579
32MP0003186_abnormal_redox_activity1.80738072
33MP0000490_abnormal_crypts_of1.69466428
34MP0002653_abnormal_ependyma_morphology1.69465550
35MP0001293_anophthalmia1.67894429
36MP0002332_abnormal_exercise_endurance1.65869820
37MP0001730_embryonic_growth_arrest1.65158159
38MP0003938_abnormal_ear_development1.64607620
39MP0002277_abnormal_respiratory_mucosa1.62175585
40MP0003786_premature_aging1.57142089
41MP0009697_abnormal_copulation1.54401678
42MP0002085_abnormal_embryonic_tissue1.53561054
43MP0005257_abnormal_intraocular_pressure1.52807925
44MP0003315_abnormal_perineum_morphology1.49198070
45MP0008789_abnormal_olfactory_epithelium1.45519645
46MP0002086_abnormal_extraembryonic_tissu1.45107399
47MP0002132_abnormal_respiratory_system1.44249503
48MP0000313_abnormal_cell_death1.38891946
49MP0002084_abnormal_developmental_patter1.38840799
50MP0001697_abnormal_embryo_size1.37002258
51MP0000678_abnormal_parathyroid_gland1.32291971
52MP0000049_abnormal_middle_ear1.29695984
53MP0003567_abnormal_fetal_cardiomyocyte1.28934468
54MP0004858_abnormal_nervous_system1.26621235
55MP0002092_abnormal_eye_morphology1.26480263
56MP0002080_prenatal_lethality1.25351083
57MP0004197_abnormal_fetal_growth/weight/1.21068681
58MP0001929_abnormal_gametogenesis1.19882817
59MP0001764_abnormal_homeostasis1.19562617
60MP0002127_abnormal_cardiovascular_syste1.17111763
61MP0000372_irregular_coat_pigmentation1.16568765
62MP0005501_abnormal_skin_physiology1.15637039
63MP0004133_heterotaxia1.13224220
64MP0003119_abnormal_digestive_system1.11816471
65MP0001661_extended_life_span1.11328922
66MP0000653_abnormal_sex_gland1.09638653
67MP0005623_abnormal_meninges_morphology1.08026933
68MP0005389_reproductive_system_phenotype1.04667778
69MP0005266_abnormal_metabolism1.04237073
70MP0002019_abnormal_tumor_incidence1.03187314
71MP0002751_abnormal_autonomic_nervous1.02399831
72MP0003136_yellow_coat_color1.00122630
73MP0004381_abnormal_hair_follicle0.99992997
74MP0002932_abnormal_joint_morphology0.99087704
75MP0001849_ear_inflammation0.96424219
76MP0000428_abnormal_craniofacial_morphol0.94475397
77MP0002114_abnormal_axial_skeleton0.93201710
78MP0000432_abnormal_head_morphology0.92072148
79MP0008995_early_reproductive_senescence0.92034957
80MP0003699_abnormal_female_reproductive0.91206848
81MP0003787_abnormal_imprinting0.90226007
82MP0002233_abnormal_nose_morphology0.89522398
83MP0001119_abnormal_female_reproductive0.88965720
84MP0002398_abnormal_bone_marrow0.87869008
85MP0003221_abnormal_cardiomyocyte_apopto0.86948302
86MP0003937_abnormal_limbs/digits/tail_de0.86895956
87MP0001145_abnormal_male_reproductive0.85661247
88MP0001919_abnormal_reproductive_system0.84231171
89MP0000762_abnormal_tongue_morphology0.83328453
90MP0001286_abnormal_eye_development0.82804350
91MP0008770_decreased_survivor_rate0.81240795
92MP0002163_abnormal_gland_morphology0.80734530
93MP0003935_abnormal_craniofacial_develop0.80596023
94MP0003705_abnormal_hypodermis_morpholog0.79760488
95MP0002210_abnormal_sex_determination0.79630010
96MP0010307_abnormal_tumor_latency0.79024431
97MP0000358_abnormal_cell_content/0.78744749
98MP0005391_vision/eye_phenotype0.78508799
99MP0003698_abnormal_male_reproductive0.77411253
100MP0005248_abnormal_Harderian_gland0.77152487
101MP0005395_other_phenotype0.76529232
102MP0002160_abnormal_reproductive_system0.75832260
103MP0003755_abnormal_palate_morphology0.75470366
104MP0008260_abnormal_autophagy0.73818884
105MP0000015_abnormal_ear_pigmentation0.73547520
106MP0002722_abnormal_immune_system0.73402739
107MP0005084_abnormal_gallbladder_morpholo0.72732030
108MP0001881_abnormal_mammary_gland0.72476029
109MP0008877_abnormal_DNA_methylation0.72174088
110MP0002970_abnormal_white_adipose0.71961072
111MP0000689_abnormal_spleen_morphology0.71712238
112MP0002111_abnormal_tail_morphology0.71302416
113MP0002429_abnormal_blood_cell0.71164358
114MP0006082_CNS_inflammation0.71094421
115MP0005310_abnormal_salivary_gland0.70900808
116MP0000703_abnormal_thymus_morphology0.70675766
117MP0009703_decreased_birth_body0.70467283
118MP0001727_abnormal_embryo_implantation0.69886860
119MP0009333_abnormal_splenocyte_physiolog0.69696087
120MP0006036_abnormal_mitochondrial_physio0.69478108
121MP0005647_abnormal_sex_gland0.69360952
122MP0004808_abnormal_hematopoietic_stem0.68922618
123MP0009672_abnormal_birth_weight0.68613729
124MP0001348_abnormal_lacrimal_gland0.68457892
125MP0003763_abnormal_thymus_physiology0.68324862
126MP0002269_muscular_atrophy0.67716447
127MP0003718_maternal_effect0.67645457
128MP0003806_abnormal_nucleotide_metabolis0.67083475
129MP0002161_abnormal_fertility/fecundity0.66733386
130MP0002177_abnormal_outer_ear0.66591908
131MP0001529_abnormal_vocalization0.66040867
132MP0005384_cellular_phenotype0.64996048
133MP0002925_abnormal_cardiovascular_devel0.63577973
134MP0002249_abnormal_larynx_morphology0.63269737
135MP0002697_abnormal_eye_size0.62209224
136MP0003861_abnormal_nervous_system0.62067098
137MP0000750_abnormal_muscle_regeneration0.60378942
138MP0002234_abnormal_pharynx_morphology0.58893179
139MP0004233_abnormal_muscle_weight0.58102087
140MP0002102_abnormal_ear_morphology0.57049877
141MP0002796_impaired_skin_barrier0.54399630
142MP0008873_increased_physiological_sensi0.54334343
143MP0003941_abnormal_skin_development0.52713380
144MP0005330_cardiomyopathy0.52343114
145MP0000716_abnormal_immune_system0.52170818

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.51087666
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.32346308
3Chromsome breakage (HP:0040012)4.89547540
4Hypochromic microcytic anemia (HP:0004840)4.62123862
5Multiple enchondromatosis (HP:0005701)4.50034118
6Ependymoma (HP:0002888)4.33999063
7Rib fusion (HP:0000902)4.13547207
8Rhabdomyosarcoma (HP:0002859)3.80298945
9Abnormal number of erythroid precursors (HP:0012131)3.68918834
10Abnormal mitochondria in muscle tissue (HP:0008316)3.67073016
11Nephroblastoma (Wilms tumor) (HP:0002667)3.64192536
12Hepatoblastoma (HP:0002884)3.61992400
13Increased CSF lactate (HP:0002490)3.60578719
14Acute necrotizing encephalopathy (HP:0006965)3.59903114
15Meckel diverticulum (HP:0002245)3.58676854
16Hepatocellular necrosis (HP:0001404)3.58102985
17Neoplasm of striated muscle (HP:0009728)3.51909016
18Abnormality of cells of the erythroid lineage (HP:0012130)3.50635717
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.46270217
20Acute encephalopathy (HP:0006846)3.41104709
21Abnormality of the ileum (HP:0001549)3.37935842
22Embryonal renal neoplasm (HP:0011794)3.35199474
23Rectal fistula (HP:0100590)3.34264553
24Rectovaginal fistula (HP:0000143)3.34264553
25Mitochondrial inheritance (HP:0001427)3.34124337
26Abnormal lung lobation (HP:0002101)3.23500358
27Abnormality of the lower motor neuron (HP:0002366)3.10727410
28Intestinal fistula (HP:0100819)3.08581280
29Increased serum lactate (HP:0002151)3.07866015
30Hepatic necrosis (HP:0002605)3.05819858
31Horseshoe kidney (HP:0000085)3.02427428
32Abnormality of the preputium (HP:0100587)3.00637681
33Astrocytoma (HP:0009592)2.98735302
34Abnormality of the astrocytes (HP:0100707)2.98735302
35Increased intramyocellular lipid droplets (HP:0012240)2.97018130
36Lipid accumulation in hepatocytes (HP:0006561)2.96019214
37Increased hepatocellular lipid droplets (HP:0006565)2.95992058
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93697032
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93697032
40Medulloblastoma (HP:0002885)2.91199143
41Impulsivity (HP:0100710)2.86659431
42Partial duplication of thumb phalanx (HP:0009944)2.86175458
43Testicular atrophy (HP:0000029)2.85697269
44Aplasia/hypoplasia of the humerus (HP:0006507)2.83520268
45Supernumerary spleens (HP:0009799)2.82921643
46Trismus (HP:0000211)2.80333829
47Vaginal fistula (HP:0004320)2.79154329
48Duodenal stenosis (HP:0100867)2.78916488
49Small intestinal stenosis (HP:0012848)2.78916488
50Hypoplasia of the fovea (HP:0007750)2.78343942
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.78343942
52Poikiloderma (HP:0001029)2.71863608
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71498809
54Progressive macrocephaly (HP:0004481)2.70875170
55Fused cervical vertebrae (HP:0002949)2.69591125
56Squamous cell carcinoma (HP:0002860)2.67261973
57Cerebral edema (HP:0002181)2.66990619
58Abnormality of DNA repair (HP:0003254)2.66396138
59Abnormality of chromosome stability (HP:0003220)2.65593352
60Aplastic anemia (HP:0001915)2.64850990
61Increased muscle lipid content (HP:0009058)2.64378490
62Lactic acidosis (HP:0003128)2.62545572
63Respiratory difficulties (HP:0002880)2.62144571
64Birth length less than 3rd percentile (HP:0003561)2.60680754
65Short humerus (HP:0005792)2.59929388
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58913736
67Abnormal protein N-linked glycosylation (HP:0012347)2.58913736
68Abnormal protein glycosylation (HP:0012346)2.58913736
69Abnormal glycosylation (HP:0012345)2.58913736
70Ragged-red muscle fibers (HP:0003200)2.54749596
71Microretrognathia (HP:0000308)2.51947129
72Partial duplication of the phalanx of hand (HP:0009999)2.48436737
73Myelodysplasia (HP:0002863)2.47828616
74Reduced antithrombin III activity (HP:0001976)2.47692844
75Bifid tongue (HP:0010297)2.44893931
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44600600
77Abnormality of the salivary glands (HP:0010286)2.44252238
78Glioma (HP:0009733)2.43452516
79Exercise intolerance (HP:0003546)2.41414103
80Hypochromic anemia (HP:0001931)2.41353945
81Pancytopenia (HP:0001876)2.40160898
82Microvesicular hepatic steatosis (HP:0001414)2.39703760
83Progressive muscle weakness (HP:0003323)2.37910450
84Type I transferrin isoform profile (HP:0003642)2.37836629
85Preauricular skin tag (HP:0000384)2.37678677
86Pendular nystagmus (HP:0012043)2.36300003
87Increased serum pyruvate (HP:0003542)2.35450251
88Absent thumb (HP:0009777)2.33932676
89Horizontal nystagmus (HP:0000666)2.32910338
90Hypoplasia of the pons (HP:0012110)2.29715286
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.29462353
92Abnormality of the duodenum (HP:0002246)2.29392584
93Hypergonadotropic hypogonadism (HP:0000815)2.28739686
94Abnormality of glycolysis (HP:0004366)2.28387010
95Premature ovarian failure (HP:0008209)2.27860946
96Glossoptosis (HP:0000162)2.26437354
97Sloping forehead (HP:0000340)2.24854512
983-Methylglutaconic aciduria (HP:0003535)2.24728612
99Triphalangeal thumb (HP:0001199)2.24265393
100Anomalous pulmonary venous return (HP:0010772)2.22248396
101Duplication of thumb phalanx (HP:0009942)2.21303312
102Cleft eyelid (HP:0000625)2.20587824
103Cerebral hypomyelination (HP:0006808)2.20562087
104Progressive external ophthalmoplegia (HP:0000590)2.19417347
105Breast hypoplasia (HP:0003187)2.18179561
106Tongue fasciculations (HP:0001308)2.18139729
107Entropion (HP:0000621)2.16504537
108IgM deficiency (HP:0002850)2.14835391
109Bone marrow hypocellularity (HP:0005528)2.14805730
110Amyotrophic lateral sclerosis (HP:0007354)2.14802069
111Abnormality of the phalanges of the hallux (HP:0010057)2.13013566
112Shawl scrotum (HP:0000049)2.11169688
113Skin tags (HP:0010609)2.10933012
114Pallor (HP:0000980)2.10239585
115Hyperglycinemia (HP:0002154)2.09950072
116Hypokinesia (HP:0002375)2.09365976
117Atresia of the external auditory canal (HP:0000413)2.09100177
118Macrocytic anemia (HP:0001972)2.08956273
119Abnormality of the labia minora (HP:0012880)2.07794716
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05653020
121Abnormality of alanine metabolism (HP:0010916)2.05653020
122Hyperalaninemia (HP:0003348)2.05653020
123Renal Fanconi syndrome (HP:0001994)2.03957955
124Reticulocytopenia (HP:0001896)2.01732718
125Facial cleft (HP:0002006)2.01652656
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00940806
127Absent radius (HP:0003974)1.99839029
128Tracheoesophageal fistula (HP:0002575)1.99436295
129Respiratory failure (HP:0002878)1.99414159
130Colon cancer (HP:0003003)1.98569139
131Selective tooth agenesis (HP:0001592)1.98303940
132Neoplasm of the oral cavity (HP:0100649)1.98072996
133Patellar aplasia (HP:0006443)1.97826056
134Rough bone trabeculation (HP:0100670)1.97028151
135Missing ribs (HP:0000921)1.96931828
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.95588357
137Abnormality of chromosome segregation (HP:0002916)1.95420093
138Abnormality of the fovea (HP:0000493)1.93447385
139Carpal bone hypoplasia (HP:0001498)1.92424183
140CNS demyelination (HP:0007305)1.89153773
141Ectopic kidney (HP:0000086)1.87365777
142Preauricular pit (HP:0004467)1.87310911
143Periauricular skin pits (HP:0100277)1.87310911
144Large earlobe (HP:0009748)1.86554737
145Abnormality of the pulmonary veins (HP:0011718)1.86286694
146High anterior hairline (HP:0009890)1.86114594
147Muscle fibrillation (HP:0010546)1.85738429
148Absent forearm bone (HP:0003953)1.85668558
149Aplasia involving forearm bones (HP:0009822)1.85668558
150Clubbing of toes (HP:0100760)1.84741549
151IgA deficiency (HP:0002720)1.84582992
152Short 5th finger (HP:0009237)1.84488489
153Abnormal cartilage morphology (HP:0002763)1.84412013
154Secondary amenorrhea (HP:0000869)1.84401074
155Abnormality of the pons (HP:0007361)1.83621196
156Septate vagina (HP:0001153)1.83404670
157Nasolacrimal duct obstruction (HP:0000579)1.83018848
158Cellular immunodeficiency (HP:0005374)1.80222172
159Sparse eyelashes (HP:0000653)1.78483374
160Optic nerve coloboma (HP:0000588)1.76237467
161Abnormality of the anterior horn cell (HP:0006802)1.75962736
162Degeneration of anterior horn cells (HP:0002398)1.75962736
163Aplasia/hypoplasia of the uterus (HP:0008684)1.75209575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.60698535
2VRK24.01198111
3GRK53.85795173
4GRK63.65674005
5TTK3.04171015
6PBK2.70199385
7GRK12.64326119
8CDC72.58714190
9ADRBK22.56861060
10WEE12.50305022
11ERN12.46875403
12BUB12.46640225
13SRPK12.35024763
14CDK72.26324950
15CSF1R2.22893640
16STK102.18620563
17BCKDK2.04639545
18SMG11.96555505
19PLK11.89955046
20MATK1.75145056
21TGFBR21.72517550
22GRK71.71116414
23CHEK21.69153799
24PDK21.67191444
25MST41.64662944
26EIF2AK11.63442499
27NEK21.58759616
28MAPK71.58355341
29EPHA21.57712014
30TYRO31.40131078
31NME11.32791597
32ACVR1B1.28628237
33CHEK11.27666053
34CCNB11.27664957
35TAF11.26174004
36KDR1.22891141
37AKT31.22677158
38MOS1.19367571
39MKNK11.18767635
40BRSK21.15193401
41TSSK61.12640656
42WNK41.10947434
43EIF2AK31.10216801
44AURKB1.07203254
45MAP3K101.06207592
46PAK41.04423895
47NME21.03015408
48TLK11.02647043
49MKNK21.01000887
50AURKA1.00561085
51CDK41.00327754
52EIF2AK20.99747615
53ATR0.98755918
54STK390.98355609
55VRK10.98341428
56OXSR10.96876244
57PRKG20.95675986
58ALK0.94275481
59WNK10.91853422
60CSNK1G30.91104464
61CAMK40.90674766
62EEF2K0.89479256
63NUAK10.88057881
64RPS6KA50.86661746
65DYRK30.86544849
66CDK190.86535492
67RPS6KB20.85486198
68CSNK1G10.85419127
69STK160.84434550
70TRIM280.83946500
71MARK30.83459801
72PLK40.83358182
73CDK20.82492328
74BRAF0.82400458
75AKT20.80239914
76MAP2K70.79905867
77MAP2K60.78696768
78SCYL20.76293870
79ATM0.75561965
80BRSK10.73098407
81PRKCI0.73015459
82FGFR30.72635974
83NEK10.71916009
84ADRBK10.70704122
85TESK20.69699820
86MAP3K110.68151461
87PIM10.68010828
88BRD40.66672864
89HIPK20.66487587
90WNK30.65220198
91RAF10.63446111
92PLK30.62006098
93IRAK30.61771211
94MAP4K10.60182366
95STK40.59854821
96CDK80.55326176
97ARAF0.54406640
98DAPK10.54245530
99CDK10.54157431
100PIM20.51811574
101MAP3K80.51113324
102MARK20.50808985
103CSNK1A1L0.50112466
104LATS20.49656602
105CSNK1G20.47933897
106YES10.47533560
107DYRK20.46638861
108ABL20.43952578
109PAK10.42023213
110MTOR0.41349641
111CSNK1E0.40718566
112MAPK110.39037322
113FLT30.38891815
114MAP4K20.38783550
115CSNK2A10.38680724
116CSNK2A20.38382434
117IKBKB0.38338879
118DAPK30.37107376
119CSK0.35701933
120RPS6KA40.33019754
121MAPK140.29973043
122MAPKAPK50.29360810
123TAOK20.28897608
124PRPF4B0.26850308
125PASK0.26684238
126ITK0.25873731
127STK38L0.25405468
128ZAK0.25191467
129GSK3B0.25096149
130CDK30.22908366
131MUSK0.21327283
132CSNK1A10.21118522
133MELK0.20673756
134CHUK0.20479107
135CLK10.20358575
136MAPK10.18935515
137PRKCD0.17399551
138PRKDC0.17186498
139MAPK120.16957560
140AKT10.15678216
141NTRK10.15571549

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.84191815
2DNA replication_Homo sapiens_hsa030304.24030695
3Mismatch repair_Homo sapiens_hsa034303.70756880
4Vitamin B6 metabolism_Homo sapiens_hsa007503.53099936
5Ribosome_Homo sapiens_hsa030103.31443940
6RNA transport_Homo sapiens_hsa030133.04831274
7Spliceosome_Homo sapiens_hsa030402.88363920
8RNA polymerase_Homo sapiens_hsa030202.79278297
9Homologous recombination_Homo sapiens_hsa034402.76861852
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.68086849
11Fanconi anemia pathway_Homo sapiens_hsa034602.65183234
12Base excision repair_Homo sapiens_hsa034102.64451124
13One carbon pool by folate_Homo sapiens_hsa006702.57330828
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45163682
15Cell cycle_Homo sapiens_hsa041102.43296307
16Nucleotide excision repair_Homo sapiens_hsa034202.19702598
17Oxidative phosphorylation_Homo sapiens_hsa001902.09051755
18Parkinsons disease_Homo sapiens_hsa050122.05850611
19Pyrimidine metabolism_Homo sapiens_hsa002402.03188513
20RNA degradation_Homo sapiens_hsa030181.98161422
21mRNA surveillance pathway_Homo sapiens_hsa030151.97010482
22Fructose and mannose metabolism_Homo sapiens_hsa000511.94663218
23Proteasome_Homo sapiens_hsa030501.89396092
24Basal transcription factors_Homo sapiens_hsa030221.85322989
25Non-homologous end-joining_Homo sapiens_hsa034501.49649239
26p53 signaling pathway_Homo sapiens_hsa041151.48816004
27Arachidonic acid metabolism_Homo sapiens_hsa005901.47946733
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47282441
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42272836
30Thyroid cancer_Homo sapiens_hsa052161.33258415
31Galactose metabolism_Homo sapiens_hsa000521.29798727
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25017937
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16851390
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11712219
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10066025
36Pyruvate metabolism_Homo sapiens_hsa006201.06613332
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03387125
38Linoleic acid metabolism_Homo sapiens_hsa005911.03065543
39Purine metabolism_Homo sapiens_hsa002301.02416644
40Alzheimers disease_Homo sapiens_hsa050101.02254107
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01402901
42Herpes simplex infection_Homo sapiens_hsa051681.00135450
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88410153
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87227718
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86614047
46Protein export_Homo sapiens_hsa030600.83444798
47Propanoate metabolism_Homo sapiens_hsa006400.81381283
48Folate biosynthesis_Homo sapiens_hsa007900.80364266
49Sulfur relay system_Homo sapiens_hsa041220.79608472
50Basal cell carcinoma_Homo sapiens_hsa052170.77208164
51Pentose phosphate pathway_Homo sapiens_hsa000300.76306424
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73248886
53MicroRNAs in cancer_Homo sapiens_hsa052060.70270644
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70256909
55Fatty acid elongation_Homo sapiens_hsa000620.68775933
56Selenocompound metabolism_Homo sapiens_hsa004500.68334827
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66567119
58Epstein-Barr virus infection_Homo sapiens_hsa051690.66036014
59N-Glycan biosynthesis_Homo sapiens_hsa005100.65507744
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65488844
61Systemic lupus erythematosus_Homo sapiens_hsa053220.65487804
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64747282
63Viral carcinogenesis_Homo sapiens_hsa052030.61479587
64mTOR signaling pathway_Homo sapiens_hsa041500.60764180
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58904377
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58800845
67HTLV-I infection_Homo sapiens_hsa051660.57125190
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.56727457
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54833676
70Primary immunodeficiency_Homo sapiens_hsa053400.54722852
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52870601
72Antigen processing and presentation_Homo sapiens_hsa046120.52752779
73Steroid biosynthesis_Homo sapiens_hsa001000.52633146
74Acute myeloid leukemia_Homo sapiens_hsa052210.51780343
75Other glycan degradation_Homo sapiens_hsa005110.50693348
76Arginine and proline metabolism_Homo sapiens_hsa003300.49342314
77Biosynthesis of amino acids_Homo sapiens_hsa012300.48169508
78Pathways in cancer_Homo sapiens_hsa052000.48072313
79Oocyte meiosis_Homo sapiens_hsa041140.46303948
80Hedgehog signaling pathway_Homo sapiens_hsa043400.45258772
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43859180
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.42542976
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.42485422
84Notch signaling pathway_Homo sapiens_hsa043300.39874208
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38918287
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.38703369
87Hippo signaling pathway_Homo sapiens_hsa043900.38406375
88Apoptosis_Homo sapiens_hsa042100.37294831
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.35981302
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.35837585
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34681828
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33575476
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31817937
94Small cell lung cancer_Homo sapiens_hsa052220.31394805
95Huntingtons disease_Homo sapiens_hsa050160.30025672
96Peroxisome_Homo sapiens_hsa041460.29938587
97Colorectal cancer_Homo sapiens_hsa052100.29718907
98Wnt signaling pathway_Homo sapiens_hsa043100.29082441
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28799235
100Metabolic pathways_Homo sapiens_hsa011000.27686885
101Fatty acid metabolism_Homo sapiens_hsa012120.27017794
102Inositol phosphate metabolism_Homo sapiens_hsa005620.26768406
103Carbon metabolism_Homo sapiens_hsa012000.26555400
104Non-small cell lung cancer_Homo sapiens_hsa052230.26320692
105Ether lipid metabolism_Homo sapiens_hsa005650.26052590
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26039551
107Phenylalanine metabolism_Homo sapiens_hsa003600.25036122
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24460161
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22592768
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22574748
111Regulation of autophagy_Homo sapiens_hsa041400.22288991
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20509424
113Cardiac muscle contraction_Homo sapiens_hsa042600.19572713
114Lysine degradation_Homo sapiens_hsa003100.17793074
115Measles_Homo sapiens_hsa051620.17280276
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17240055
117Legionellosis_Homo sapiens_hsa051340.16980403
118Sulfur metabolism_Homo sapiens_hsa009200.16548912
119Hematopoietic cell lineage_Homo sapiens_hsa046400.16500479
120Tyrosine metabolism_Homo sapiens_hsa003500.16144873
121Bladder cancer_Homo sapiens_hsa052190.16031679
122Influenza A_Homo sapiens_hsa051640.15919349
123Shigellosis_Homo sapiens_hsa051310.14560856
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12902004
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12420825
126Collecting duct acid secretion_Homo sapiens_hsa049660.12151266
127Alcoholism_Homo sapiens_hsa050340.11724633
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11155186
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.10077835
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09784909
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.09383361
132TGF-beta signaling pathway_Homo sapiens_hsa043500.09198382
133Glutathione metabolism_Homo sapiens_hsa004800.08361633
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06794015
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.03549094
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02151732
137Butanoate metabolism_Homo sapiens_hsa006500.01124857
138Hepatitis B_Homo sapiens_hsa05161-0.0297409
139Fatty acid degradation_Homo sapiens_hsa00071-0.0161444

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