RPUSD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.92571522
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.02197454
3ATP synthesis coupled proton transport (GO:0015986)4.71208793
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71208793
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.68813931
6glycine metabolic process (GO:0006544)4.67860384
7chaperone-mediated protein transport (GO:0072321)4.56009636
8protein complex biogenesis (GO:0070271)4.52859267
9mitochondrial respiratory chain complex assembly (GO:0033108)4.37942620
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.37659552
11NADH dehydrogenase complex assembly (GO:0010257)4.37659552
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37659552
13L-phenylalanine metabolic process (GO:0006558)4.29941985
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29941985
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.25031640
16folic acid metabolic process (GO:0046655)4.24682249
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21481635
18serine family amino acid biosynthetic process (GO:0009070)4.05574545
19proteasome assembly (GO:0043248)4.02125626
20respiratory electron transport chain (GO:0022904)4.00854820
21base-excision repair, AP site formation (GO:0006285)3.99678874
22maturation of SSU-rRNA (GO:0030490)3.99270461
23nucleobase biosynthetic process (GO:0046112)3.98574472
24serine family amino acid catabolic process (GO:0009071)3.96169459
25electron transport chain (GO:0022900)3.95714878
26L-phenylalanine catabolic process (GO:0006559)3.93869314
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.93869314
28respiratory chain complex IV assembly (GO:0008535)3.90751098
29serine family amino acid metabolic process (GO:0009069)3.88483609
30formation of translation preinitiation complex (GO:0001731)3.86950004
31purine nucleobase biosynthetic process (GO:0009113)3.86826972
32metallo-sulfur cluster assembly (GO:0031163)3.84897855
33iron-sulfur cluster assembly (GO:0016226)3.84897855
34pyrimidine nucleotide catabolic process (GO:0006244)3.84144827
35protein targeting to mitochondrion (GO:0006626)3.82679332
36L-serine metabolic process (GO:0006563)3.76166197
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68853009
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68853009
39folic acid-containing compound biosynthetic process (GO:0009396)3.68788431
40cytochrome complex assembly (GO:0017004)3.68735857
41establishment of protein localization to mitochondrion (GO:0072655)3.61109462
42pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.58921158
43cysteine metabolic process (GO:0006534)3.57545836
44glyoxylate metabolic process (GO:0046487)3.57413097
45amino acid salvage (GO:0043102)3.57225730
46L-methionine salvage (GO:0071267)3.57225730
47L-methionine biosynthetic process (GO:0071265)3.57225730
48peptidyl-histidine modification (GO:0018202)3.50736332
49aromatic amino acid family catabolic process (GO:0009074)3.50560187
50ribosomal small subunit assembly (GO:0000028)3.48651056
51ribosome assembly (GO:0042255)3.40895964
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39333077
53protein localization to mitochondrion (GO:0070585)3.39274271
54ubiquinone biosynthetic process (GO:0006744)3.37884142
55* pseudouridine synthesis (GO:0001522)3.33744445
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31251791
57ribosome biogenesis (GO:0042254)3.29233098
58sulfur amino acid biosynthetic process (GO:0000097)3.29099321
59cullin deneddylation (GO:0010388)3.24584760
60rRNA methylation (GO:0031167)3.22836709
61sulfur amino acid catabolic process (GO:0000098)3.21363053
62deoxyribonucleotide catabolic process (GO:0009264)3.21360970
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20236180
64tRNA processing (GO:0008033)3.18835694
65ribosomal large subunit biogenesis (GO:0042273)3.18329888
66protein deneddylation (GO:0000338)3.17788763
67pteridine-containing compound biosynthetic process (GO:0042559)3.17071650
68maturation of 5.8S rRNA (GO:0000460)3.16421486
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14640983
70DNA replication initiation (GO:0006270)3.12241557
71tryptophan catabolic process (GO:0006569)3.12237460
72indole-containing compound catabolic process (GO:0042436)3.12237460
73indolalkylamine catabolic process (GO:0046218)3.12237460
74ribonucleoprotein complex biogenesis (GO:0022613)3.12149356
75GTP biosynthetic process (GO:0006183)3.09256741
76deoxyribose phosphate catabolic process (GO:0046386)3.09005350
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08589281
78folic acid-containing compound metabolic process (GO:0006760)3.06800081
79DNA strand elongation involved in DNA replication (GO:0006271)3.05946123
80viral transcription (GO:0019083)3.05507602
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05087758
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05087758
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05087758
84pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.03615415
85translation (GO:0006412)3.03540611
86kynurenine metabolic process (GO:0070189)3.03474243
87DNA damage response, detection of DNA damage (GO:0042769)3.02915971
88aldehyde catabolic process (GO:0046185)3.02521859
89guanosine-containing compound biosynthetic process (GO:1901070)3.01623176
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01616921
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01544781
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01544781
93translational elongation (GO:0006414)3.01253277
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00216880
95ubiquinone metabolic process (GO:0006743)2.99926807
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99616097
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99578151
98translational termination (GO:0006415)2.98882637
99tRNA metabolic process (GO:0006399)2.98595161
100methionine metabolic process (GO:0006555)2.98229615
101transcription from mitochondrial promoter (GO:0006390)2.98186986
102tetrahydrofolate metabolic process (GO:0046653)2.98136391
103galactose catabolic process (GO:0019388)2.97201557
104purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96828636
105purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96573467
106water-soluble vitamin biosynthetic process (GO:0042364)2.96328423
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96195783
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.96195783
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94897208
110methionine biosynthetic process (GO:0009086)2.94668908
111mitochondrial transport (GO:0006839)2.94291580
112aromatic amino acid family metabolic process (GO:0009072)2.93381551
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.93310502
114ATP biosynthetic process (GO:0006754)2.92903972
115bile acid biosynthetic process (GO:0006699)2.91603631
116proline biosynthetic process (GO:0006561)2.91158261
117regulation of cellular amino acid metabolic process (GO:0006521)2.90953790
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89902723
119ncRNA processing (GO:0034470)2.89681559
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89656887
121ribosomal small subunit biogenesis (GO:0042274)2.89575289
122nucleoside salvage (GO:0043174)2.89497442
123UTP biosynthetic process (GO:0006228)2.89076779
124DNA strand elongation (GO:0022616)2.88768043
125rRNA processing (GO:0006364)2.88750936
126pteridine-containing compound metabolic process (GO:0042558)2.88716734
127amino-acid betaine metabolic process (GO:0006577)2.88432837
128telomere maintenance via semi-conservative replication (GO:0032201)2.88365864
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87616888
130positive regulation of ligase activity (GO:0051351)2.87397885
131oxidative phosphorylation (GO:0006119)2.87373157
132urea cycle (GO:0000050)2.87249204
133urea metabolic process (GO:0019627)2.87249204
134spliceosomal snRNP assembly (GO:0000387)2.86960117
135chromatin remodeling at centromere (GO:0031055)2.86869664
136tryptophan metabolic process (GO:0006568)2.86831527
137one-carbon metabolic process (GO:0006730)2.86340255
138proline metabolic process (GO:0006560)2.85350252
139translational initiation (GO:0006413)2.84115317
140nitrogen cycle metabolic process (GO:0071941)2.81762621
141alpha-amino acid catabolic process (GO:1901606)2.78210543
142negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77957643
143negative regulation of ligase activity (GO:0051352)2.77957643
144rRNA metabolic process (GO:0016072)2.76365545
145lysine metabolic process (GO:0006553)2.75708201
146lysine catabolic process (GO:0006554)2.75708201
147imidazole-containing compound metabolic process (GO:0052803)2.75686383
148mitochondrial RNA metabolic process (GO:0000959)2.75289520
149sulfur amino acid metabolic process (GO:0000096)2.74590525
150cellular component biogenesis (GO:0044085)2.69207471
151DNA replication checkpoint (GO:0000076)2.68849204
152regulation of posttranscriptional gene silencing (GO:0060147)2.68340368
153regulation of gene silencing by miRNA (GO:0060964)2.68340368
154regulation of gene silencing by RNA (GO:0060966)2.68340368
155termination of RNA polymerase III transcription (GO:0006386)2.68215217
156transcription elongation from RNA polymerase III promoter (GO:0006385)2.68215217
157termination of RNA polymerase I transcription (GO:0006363)2.67605427
158rRNA modification (GO:0000154)2.66368255
159homocysteine metabolic process (GO:0050667)2.64389308
160pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.63858365
161regulation of mitochondrial translation (GO:0070129)2.62991730
162IMP biosynthetic process (GO:0006188)2.62389203
163negative regulation of fibrinolysis (GO:0051918)2.62173950
164aspartate family amino acid biosynthetic process (GO:0009067)2.61420816
165mitotic metaphase plate congression (GO:0007080)2.61224685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.16176234
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.03173001
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85374508
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.61370954
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20374347
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02752464
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92875450
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.90782264
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82437296
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.81357995
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.80932956
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65515393
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64488035
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56398474
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55452814
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39752733
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.30005129
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27028189
19XRN2_22483619_ChIP-Seq_HELA_Human2.21884423
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18506294
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18490681
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15573902
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11402300
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08592997
25VDR_23849224_ChIP-Seq_CD4+_Human2.03502635
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01912298
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00469407
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00310647
29GABP_19822575_ChIP-Seq_HepG2_Human1.97020642
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96540245
31DCP1A_22483619_ChIP-Seq_HELA_Human1.89998753
32FOXP3_21729870_ChIP-Seq_TREG_Human1.88325311
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.86558703
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82201423
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79700621
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79027340
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77501683
38* SRF_21415370_ChIP-Seq_HL-1_Mouse1.77337174
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.72332919
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67096503
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62026694
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61871971
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61031843
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60756214
45MYC_18940864_ChIP-ChIP_HL60_Human1.59379140
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58504840
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56768510
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55301856
49TTF2_22483619_ChIP-Seq_HELA_Human1.53937833
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52317974
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.51518458
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46316796
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43827567
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42582592
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41751150
56KDM5A_27292631_Chip-Seq_BREAST_Human1.40438894
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39177610
58CIITA_25753668_ChIP-Seq_RAJI_Human1.35772025
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.33723568
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32707355
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31483708
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29900332
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28407299
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26554842
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25674389
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23789292
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23021594
68AR_21909140_ChIP-Seq_LNCAP_Human1.22562423
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22041005
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.20137402
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20047696
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18723328
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17355157
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16697881
75MYC_22102868_ChIP-Seq_BL_Human1.15260201
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15062232
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14264270
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13287037
79ZNF274_21170338_ChIP-Seq_K562_Hela1.12405577
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11255283
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10541679
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10449096
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10341146
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08174941
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04773243
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04698785
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04291981
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01670821
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01659880
90TFEB_21752829_ChIP-Seq_HELA_Human1.01458230
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01402334
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00625173
93ELK1_19687146_ChIP-ChIP_HELA_Human0.97827572
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96609279
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96435039
96P68_20966046_ChIP-Seq_HELA_Human0.95506636
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94690308
98BCL6_27268052_Chip-Seq_Bcells_Human0.94044521
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93035646
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92806698
101E2F1_20622854_ChIP-Seq_HELA_Human0.92564507
102IRF1_19129219_ChIP-ChIP_H3396_Human0.91846204
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91430267
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90361773
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.90233584
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90190228
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89961160
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.89599629
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89592041
110PHF8_20622854_ChIP-Seq_HELA_Human0.89527425
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89331387
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88643876
113TP53_22573176_ChIP-Seq_HFKS_Human0.87971274
114* YY1_22570637_ChIP-Seq_MALME-3M_Human0.87396483
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87062962
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.86824833
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86704059
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86606200
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86380230
120VDR_21846776_ChIP-Seq_THP-1_Human0.86240397
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86236929
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86217745
123ERA_21632823_ChIP-Seq_H3396_Human0.80675558
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.78529329
125BCOR_27268052_Chip-Seq_Bcells_Human0.75007006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.41048748
2MP0005360_urolithiasis5.11022322
3MP0003806_abnormal_nucleotide_metabolis4.75689055
4MP0005085_abnormal_gallbladder_physiolo4.15932670
5MP0005365_abnormal_bile_salt4.10758537
6MP0003693_abnormal_embryo_hatching3.93596902
7MP0009840_abnormal_foam_cell3.41733979
8MP0004957_abnormal_blastocyst_morpholog3.16429246
9MP0008875_abnormal_xenobiotic_pharmacok3.03740452
10MP0003111_abnormal_nucleus_morphology2.81831568
11MP0006292_abnormal_olfactory_placode2.69923822
12MP0005332_abnormal_amino_acid2.51153307
13MP0000372_irregular_coat_pigmentation2.48910675
14MP0010094_abnormal_chromosome_stability2.35817057
15MP0003077_abnormal_cell_cycle2.25399761
16MP0010329_abnormal_lipoprotein_level2.19307976
17MP0004019_abnormal_vitamin_homeostasis2.12140678
18MP0008877_abnormal_DNA_methylation2.11449039
19MP0003186_abnormal_redox_activity2.07127235
20MP0009379_abnormal_foot_pigmentation2.04964360
21MP0006036_abnormal_mitochondrial_physio2.01079404
22MP0003718_maternal_effect1.94180374
23MP0003646_muscle_fatigue1.92485011
24MP0002938_white_spotting1.88643371
25MP0001764_abnormal_homeostasis1.87824495
26MP0005083_abnormal_biliary_tract1.87097144
27MP0001529_abnormal_vocalization1.82013453
28MP0008058_abnormal_DNA_repair1.80959289
29MP0005319_abnormal_enzyme/_coenzyme1.71028743
30MP0008057_abnormal_DNA_replication1.68904520
31MP0006035_abnormal_mitochondrial_morpho1.67966393
32MP0005670_abnormal_white_adipose1.65703011
33MP0008789_abnormal_olfactory_epithelium1.64676649
34MP0000609_abnormal_liver_physiology1.64440764
35MP0003252_abnormal_bile_duct1.63853876
36MP0001730_embryonic_growth_arrest1.63290837
37MP0002653_abnormal_ependyma_morphology1.62814313
38MP0003787_abnormal_imprinting1.61267117
39MP0003195_calcinosis1.58005241
40MP0001666_abnormal_nutrient_absorption1.54145214
41MP0001986_abnormal_taste_sensitivity1.53309563
42MP0004145_abnormal_muscle_electrophysio1.44030121
43MP0002163_abnormal_gland_morphology1.40414407
44MP0001968_abnormal_touch/_nociception1.39849839
45MP0008932_abnormal_embryonic_tissue1.38515688
46MP0003786_premature_aging1.35975830
47MP0002736_abnormal_nociception_after1.35199472
48MP0002638_abnormal_pupillary_reflex1.33867289
49MP0005389_reproductive_system_phenotype1.33092441
50MP0000598_abnormal_liver_morphology1.31210326
51MP0003121_genomic_imprinting1.31057979
52MP0008007_abnormal_cellular_replicative1.29562403
53MP0009643_abnormal_urine_homeostasis1.28489989
54MP0005075_abnormal_melanosome_morpholog1.27559775
55MP0002138_abnormal_hepatobiliary_system1.26541680
56MP0002102_abnormal_ear_morphology1.23799427
57MP0008872_abnormal_physiological_respon1.21926155
58MP0004142_abnormal_muscle_tone1.21169187
59MP0006072_abnormal_retinal_apoptosis1.19815479
60MP0005551_abnormal_eye_electrophysiolog1.17632679
61MP0002234_abnormal_pharynx_morphology1.17023472
62MP0004147_increased_porphyrin_level1.16253647
63MP0002095_abnormal_skin_pigmentation1.15985727
64MP0002837_dystrophic_cardiac_calcinosis1.15408818
65MP0002118_abnormal_lipid_homeostasis1.14492828
66MP0003656_abnormal_erythrocyte_physiolo1.14369272
67MP0005499_abnormal_olfactory_system1.13638370
68MP0005394_taste/olfaction_phenotype1.13638370
69MP0002080_prenatal_lethality1.11168603
70MP0001919_abnormal_reproductive_system1.10325046
71MP0005584_abnormal_enzyme/coenzyme_acti1.09258749
72MP0000358_abnormal_cell_content/1.08886094
73MP0001697_abnormal_embryo_size1.08734060
74MP0001905_abnormal_dopamine_level1.08326963
75MP0004133_heterotaxia1.07822253
76MP0005380_embryogenesis_phenotype1.07044087
77MP0001672_abnormal_embryogenesis/_devel1.07044087
78MP0005646_abnormal_pituitary_gland1.06968387
79MP0006276_abnormal_autonomic_nervous1.06219603
80MP0005451_abnormal_body_composition1.05864152
81MP0005084_abnormal_gallbladder_morpholo1.04186312
82MP0003123_paternal_imprinting1.04068316
83MP0000049_abnormal_middle_ear1.02954910
84MP0000350_abnormal_cell_proliferation1.02922274
85MP0001188_hyperpigmentation1.02634652
86MP0002132_abnormal_respiratory_system1.02484488
87MP0009046_muscle_twitch1.02202195
88MP0005636_abnormal_mineral_homeostasis1.02024434
89MP0009697_abnormal_copulation1.01115951
90MP0005410_abnormal_fertilization1.00835926
91MP0005266_abnormal_metabolism0.99219976
92MP0009333_abnormal_splenocyte_physiolog0.98840234
93MP0001853_heart_inflammation0.98654732
94MP0003698_abnormal_male_reproductive0.97666050
95MP0001661_extended_life_span0.96071480
96MP0000015_abnormal_ear_pigmentation0.95941585
97MP0000566_synostosis0.95656670
98MP0005423_abnormal_somatic_nervous0.95447648
99MP0001293_anophthalmia0.95232926
100MP0005645_abnormal_hypothalamus_physiol0.93554183
101MP0005379_endocrine/exocrine_gland_phen0.93540382
102MP0003984_embryonic_growth_retardation0.93002297
103MP0002088_abnormal_embryonic_growth/wei0.92481782
104MP0003119_abnormal_digestive_system0.92431307
105MP0003136_yellow_coat_color0.91047575
106MP0002086_abnormal_extraembryonic_tissu0.88320037
107MP0010030_abnormal_orbit_morphology0.88123869
108MP0002019_abnormal_tumor_incidence0.86810058
109MP0000313_abnormal_cell_death0.86404227
110MP0001756_abnormal_urination0.84344164
111MP0005376_homeostasis/metabolism_phenot0.80621989
112MP0002269_muscular_atrophy0.79491294
113MP0009672_abnormal_birth_weight0.78626393
114MP0005253_abnormal_eye_physiology0.78103367
115MP0000631_abnormal_neuroendocrine_gland0.77710730
116MP0000689_abnormal_spleen_morphology0.76643916
117MP0003567_abnormal_fetal_cardiomyocyte0.76574262
118MP0002085_abnormal_embryonic_tissue0.76203592
119MP0003191_abnormal_cellular_cholesterol0.73104193
120MP0010352_gastrointestinal_tract_polyps0.72552984
121MP0002822_catalepsy0.72343378
122MP0002735_abnormal_chemical_nociception0.71381879
123MP0008469_abnormal_protein_level0.70596705
124MP0003941_abnormal_skin_development0.69652717
125MP0000750_abnormal_muscle_regeneration0.69611099
126MP0002722_abnormal_immune_system0.69386944
127MP0001727_abnormal_embryo_implantation0.69310600
128MP0003011_delayed_dark_adaptation0.69248462
129MP0001145_abnormal_male_reproductive0.68951463
130MP0001545_abnormal_hematopoietic_system0.68579639
131MP0005397_hematopoietic_system_phenotyp0.68579639
132MP0003763_abnormal_thymus_physiology0.68413174
133MP0005395_other_phenotype0.68192320
134MP0002876_abnormal_thyroid_physiology0.67499230
135MP0000490_abnormal_crypts_of0.67051427
136MP0008995_early_reproductive_senescence0.66473564
137MP0009763_increased_sensitivity_to0.66409840
138MP0005330_cardiomyopathy0.66242866
139MP0009642_abnormal_blood_homeostasis0.65917233
140MP0001324_abnormal_eye_pigmentation0.65417312
141MP0003137_abnormal_impulse_conducting0.65116707
142MP0005174_abnormal_tail_pigmentation0.64892597
143MP0002161_abnormal_fertility/fecundity0.64595008
144MP0002210_abnormal_sex_determination0.63657402
145MP0001929_abnormal_gametogenesis0.62569150
146MP0002160_abnormal_reproductive_system0.62395399
147MP0002084_abnormal_developmental_patter0.61745343
148MP0002254_reproductive_system_inflammat0.61472727
149MP0002396_abnormal_hematopoietic_system0.61132738
150MP0000653_abnormal_sex_gland0.60689425
151MP0005220_abnormal_exocrine_pancreas0.59199474
152MP0003880_abnormal_central_pattern0.59180620
153MP0002970_abnormal_white_adipose0.57509799
154MP0001119_abnormal_female_reproductive0.57247978
155MP0008873_increased_physiological_sensi0.56345860

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.92003963
2Hypobetalipoproteinemia (HP:0003563)4.72959386
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.61603263
4Hyperglycinemia (HP:0002154)4.23833375
5Abnormality of pyrimidine metabolism (HP:0004353)4.18436229
6Hyperglycinuria (HP:0003108)4.15020555
7Intrahepatic cholestasis (HP:0001406)4.11713113
8Progressive macrocephaly (HP:0004481)3.93153331
9Xanthomatosis (HP:0000991)3.93090954
10Lipid accumulation in hepatocytes (HP:0006561)3.81913176
11Increased hepatocellular lipid droplets (HP:0006565)3.80946155
12Abnormality of serine family amino acid metabolism (HP:0010894)3.63332202
13Abnormality of glycine metabolism (HP:0010895)3.63332202
14Increased intramyocellular lipid droplets (HP:0012240)3.60306076
15Hyperammonemia (HP:0001987)3.58706867
16Hyperlipoproteinemia (HP:0010980)3.43717782
17Birth length less than 3rd percentile (HP:0003561)3.43162451
18Renal Fanconi syndrome (HP:0001994)3.31581561
19Deep venous thrombosis (HP:0002625)3.28928597
20Increased muscle lipid content (HP:0009058)3.24933793
21Delayed CNS myelination (HP:0002188)3.24653100
22Prolonged partial thromboplastin time (HP:0003645)3.23242648
23Hypolipoproteinemia (HP:0010981)3.17933939
24Oral leukoplakia (HP:0002745)3.16388253
25Dicarboxylic aciduria (HP:0003215)3.08541789
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.08541789
27Lethargy (HP:0001254)3.06710032
28Hepatic necrosis (HP:0002605)3.02000243
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95014158
30Ketosis (HP:0001946)2.92825693
31Cerebral edema (HP:0002181)2.92348151
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92288814
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92288814
34Exercise intolerance (HP:0003546)2.90959137
35Abnormality of serum amino acid levels (HP:0003112)2.90669038
36Gout (HP:0001997)2.90574570
373-Methylglutaconic aciduria (HP:0003535)2.87789595
38Abnormality of fatty-acid metabolism (HP:0004359)2.87181683
39Breast hypoplasia (HP:0003187)2.86992713
40Abnormality of methionine metabolism (HP:0010901)2.83541558
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.80263701
42Hypoglycemic coma (HP:0001325)2.79617789
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.77342783
44Reticulocytopenia (HP:0001896)2.75336476
45Hepatocellular necrosis (HP:0001404)2.72726233
46Increased serum lactate (HP:0002151)2.70840283
47Abnormality of cells of the erythroid lineage (HP:0012130)2.69889184
48Respiratory failure (HP:0002878)2.68523851
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68437001
50Carpal bone hypoplasia (HP:0001498)2.66170844
51Brushfield spots (HP:0001088)2.64307466
52Abnormal number of erythroid precursors (HP:0012131)2.64264335
53Abnormality of nucleobase metabolism (HP:0010932)2.60736226
54Multiple enchondromatosis (HP:0005701)2.59680539
55Rough bone trabeculation (HP:0100670)2.59374255
56Testicular atrophy (HP:0000029)2.58534320
57Optic disc pallor (HP:0000543)2.55211817
58Abnormal protein glycosylation (HP:0012346)2.51458658
59Abnormal glycosylation (HP:0012345)2.51458658
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51458658
61Abnormal protein N-linked glycosylation (HP:0012347)2.51458658
62Megaloblastic anemia (HP:0001889)2.50254337
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47657447
64Abnormality of alanine metabolism (HP:0010916)2.47657447
65Hyperalaninemia (HP:0003348)2.47657447
66Macrocytic anemia (HP:0001972)2.45809419
67Nausea (HP:0002018)2.45768942
68Hypoplasia of the pons (HP:0012110)2.45629534
69Microvesicular hepatic steatosis (HP:0001414)2.44463296
70Lactic acidosis (HP:0003128)2.43382341
71Acute encephalopathy (HP:0006846)2.42342683
72Generalized aminoaciduria (HP:0002909)2.40697587
73CNS demyelination (HP:0007305)2.39383911
74Proximal tubulopathy (HP:0000114)2.37694203
75Progressive microcephaly (HP:0000253)2.37535440
76Increased serum pyruvate (HP:0003542)2.36696255
77Abnormality of glycolysis (HP:0004366)2.36696255
78Rhabdomyolysis (HP:0003201)2.36591847
79Increased CSF lactate (HP:0002490)2.36004878
80Absent thumb (HP:0009777)2.35085705
81Respiratory difficulties (HP:0002880)2.35000006
82Hyperbilirubinemia (HP:0002904)2.34709178
83Cerebral hypomyelination (HP:0006808)2.32988003
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32082618
85Abnormality of the pons (HP:0007361)2.31856185
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30902769
87Hypoalphalipoproteinemia (HP:0003233)2.27188727
88Malnutrition (HP:0004395)2.25708618
89Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23691593
90Methylmalonic aciduria (HP:0012120)2.21109489
91Fat malabsorption (HP:0002630)2.19596372
92Abnormality of the intrinsic pathway (HP:0010989)2.18919293
93Retinal dysplasia (HP:0007973)2.18342684
94Pancytopenia (HP:0001876)2.17372020
95Pancreatic cysts (HP:0001737)2.14513828
96Mitochondrial inheritance (HP:0001427)2.14346323
97Progressive muscle weakness (HP:0003323)2.14094331
98Metabolic acidosis (HP:0001942)2.12788694
99Complement deficiency (HP:0004431)2.11482739
100Leukodystrophy (HP:0002415)2.11448069
101Colon cancer (HP:0003003)2.10844006
102Vomiting (HP:0002013)2.10010519
103Exertional dyspnea (HP:0002875)2.09402212
104Death in infancy (HP:0001522)2.08742952
105Spastic diplegia (HP:0001264)2.08406812
106Pancreatic fibrosis (HP:0100732)2.04933911
107Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03541379
108Ketoacidosis (HP:0001993)2.00894095
109Congenital stationary night blindness (HP:0007642)2.00059461
110Microretrognathia (HP:0000308)1.99428631
111Meckel diverticulum (HP:0002245)1.99311659
112Selective tooth agenesis (HP:0001592)1.99004217
113Molar tooth sign on MRI (HP:0002419)1.98789712
114Abnormality of midbrain morphology (HP:0002418)1.98789712
115Horseshoe kidney (HP:0000085)1.95405714
116Abnormality of the ileum (HP:0001549)1.94523698
117Emotional lability (HP:0000712)1.94026485
118Reduced antithrombin III activity (HP:0001976)1.93667603
119Joint hemorrhage (HP:0005261)1.93544761
120Acute necrotizing encephalopathy (HP:0006965)1.93321930
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92769276
122Methylmalonic acidemia (HP:0002912)1.91883394
123Type 2 muscle fiber atrophy (HP:0003554)1.91411192
124Type II lissencephaly (HP:0007260)1.91065805
125Patellar aplasia (HP:0006443)1.89963688
126Irritability (HP:0000737)1.89895164
127Cerebral palsy (HP:0100021)1.88899430
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88472504
129Ragged-red muscle fibers (HP:0003200)1.88460373
130Aplastic anemia (HP:0001915)1.88135317
131Cellular immunodeficiency (HP:0005374)1.88036815
132Abnormality of renal resorption (HP:0011038)1.87917675
133Abnormal trabecular bone morphology (HP:0100671)1.87341268
134Abnormality of reticulocytes (HP:0004312)1.86860491
135Abnormality of the heme biosynthetic pathway (HP:0010472)1.86477064
136Muscle fiber atrophy (HP:0100295)1.85975531
137Opisthotonus (HP:0002179)1.84560486
138Type I transferrin isoform profile (HP:0003642)1.84273447
139Increased serum ferritin (HP:0003281)1.83633207
140Ependymoma (HP:0002888)1.83106742
141Abnormal mitochondria in muscle tissue (HP:0008316)1.83020110
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.82953674
143Trismus (HP:0000211)1.82821893
144Aplasia/Hypoplasia of the patella (HP:0006498)1.82728446
145Abnormality of purine metabolism (HP:0004352)1.81886224
146Abnormality of the common coagulation pathway (HP:0010990)1.81593434
147Impulsivity (HP:0100710)1.80996786
148Chromsome breakage (HP:0040012)1.80199456
149Cerebellar dysplasia (HP:0007033)1.78399752
150Abnormality of the preputium (HP:0100587)1.77795515
151Concave nail (HP:0001598)1.77553730
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77362418
153Pallor (HP:0000980)1.77089349
154Sclerocornea (HP:0000647)1.76626235
155Glycosuria (HP:0003076)1.74172136
156Abnormality of urine glucose concentration (HP:0011016)1.74172136
157Aplasia/hypoplasia of the uterus (HP:0008684)1.73319333
158Abnormality of DNA repair (HP:0003254)1.68797458
159X-linked dominant inheritance (HP:0001423)1.68146058
160CNS hypomyelination (HP:0003429)1.67582782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.52619328
2VRK25.05052644
3BCKDK4.25280752
4WEE13.96620407
5NUAK12.88482642
6EPHA22.76297060
7ACVR1B2.70276023
8STK162.68209474
9EIF2AK12.61644354
10NME22.39636630
11TESK22.33948387
12SRPK12.31682830
13TSSK62.12869686
14PBK2.00518604
15CDC71.95828473
16KDR1.85540912
17TTK1.80353065
18NEK21.76061981
19MAP3K111.72907690
20PLK41.71668079
21BRSK21.65662198
22TGFBR11.64122009
23DYRK31.62146200
24MAP4K21.61722546
25WNK41.50334930
26PLK11.49234534
27EIF2AK31.48583981
28MAP3K101.47770463
29CDK71.43023928
30AURKA1.39157470
31NEK11.38082438
32ARAF1.37724930
33RPS6KB21.34797574
34TLK11.31173327
35LIMK11.27140265
36WNK31.26995767
37CDK191.26194017
38MAPK151.26136413
39ZAK1.23786017
40NME11.23605430
41BRAF1.23373519
42BMPR1B1.23090890
43AURKB1.22613956
44PAK41.21494186
45IRAK31.20062814
46GRK61.17931818
47VRK11.15581977
48TRIM281.14130002
49CDK81.12562587
50BRSK11.12057217
51TESK11.11604106
52PASK1.09887500
53PRKCI1.09244403
54MAP4K11.08969205
55CDK41.08057709
56CCNB11.07098137
57PINK11.07093734
58CHEK21.06704319
59PIM21.06393784
60CSNK1A1L1.05933401
61SCYL21.05538441
62ADRBK21.03386790
63FLT30.97685944
64CSNK1G20.97010313
65PDK30.96606007
66PDK40.96606007
67ATR0.91768913
68ERN10.89666721
69MAP3K80.87405090
70INSRR0.87183739
71TXK0.85519434
72MAP2K20.85468436
73TAF10.82220009
74GRK10.81610313
75ABL20.79661981
76MAP2K70.78619439
77PLK30.78355713
78MST40.78118529
79STK38L0.75905912
80PHKG20.73930981
81PHKG10.73930981
82CSNK2A20.71598831
83PIM10.71416976
84FRK0.71112070
85MAPK110.69271702
86CHEK10.67954280
87TAOK30.67415012
88RPS6KA40.66364321
89MAP2K30.63165995
90CSNK2A10.62578617
91MUSK0.60395701
92DAPK10.57542839
93CSNK1G10.57028736
94CDK20.55217256
95MAPKAPK50.53474939
96PAK10.53208280
97STK40.52417758
98AKT20.52144146
99TYK20.51772047
100MAPKAPK30.51170287
101PNCK0.50983683
102STK100.50982695
103FGFR40.50314577
104MAPK130.47255649
105AKT30.47202128
106PIK3CG0.46299132
107CSNK1G30.45960490
108RAF10.45292556
109MAP3K30.42805573
110CSNK1A10.41808707
111NLK0.41589806
112DAPK30.41540685
113OXSR10.41257183
114PKN20.41143031
115CAMKK20.38587381
116MAP3K40.38457713
117PKN10.37942578
118OBSCN0.37515597
119ILK0.36843698
120MKNK10.36423963
121MARK30.36143713
122CLK10.35495666
123SMG10.35253830
124CSNK1E0.35071797
125PDK20.34553498
126ATM0.34169600
127LRRK20.33995410
128IKBKB0.32257817
129LATS20.30275898
130RPS6KA50.29875832
131PRKCQ0.29607405
132BTK0.29428824
133MTOR0.29114992
134BRD40.28460892
135CDK60.27712837
136DYRK20.27248986
137SIK10.26932830
138EEF2K0.26388821
139ZAP700.25144103
140CDK10.24919786

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.86467611
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.69589518
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60316016
4Ribosome_Homo sapiens_hsa030102.58743738
5DNA replication_Homo sapiens_hsa030302.54138405
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46609976
7Mismatch repair_Homo sapiens_hsa034302.33420521
8RNA polymerase_Homo sapiens_hsa030202.33105008
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29325086
10One carbon pool by folate_Homo sapiens_hsa006702.20572853
11Sulfur relay system_Homo sapiens_hsa041222.11074718
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.09077520
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07327782
14Folate biosynthesis_Homo sapiens_hsa007901.98349408
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95677865
16Base excision repair_Homo sapiens_hsa034101.93018531
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92195133
18Selenocompound metabolism_Homo sapiens_hsa004501.90366028
19Pyrimidine metabolism_Homo sapiens_hsa002401.89447093
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.87780628
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85340194
22Biosynthesis of amino acids_Homo sapiens_hsa012301.83643648
23Spliceosome_Homo sapiens_hsa030401.75280280
24Arginine biosynthesis_Homo sapiens_hsa002201.74576465
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74002980
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72395804
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69955730
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68239792
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.66311960
30Tryptophan metabolism_Homo sapiens_hsa003801.64664304
31Fatty acid degradation_Homo sapiens_hsa000711.61210647
32RNA transport_Homo sapiens_hsa030131.55985791
33Propanoate metabolism_Homo sapiens_hsa006401.54478239
34Carbon metabolism_Homo sapiens_hsa012001.54157597
35Peroxisome_Homo sapiens_hsa041461.52309917
36Nucleotide excision repair_Homo sapiens_hsa034201.49990022
37Vitamin B6 metabolism_Homo sapiens_hsa007501.49880149
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49353835
39Pentose phosphate pathway_Homo sapiens_hsa000301.36237037
40Nitrogen metabolism_Homo sapiens_hsa009101.34767240
41Pyruvate metabolism_Homo sapiens_hsa006201.34351988
42Cardiac muscle contraction_Homo sapiens_hsa042601.31249166
43Homologous recombination_Homo sapiens_hsa034401.30493502
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24203596
45beta-Alanine metabolism_Homo sapiens_hsa004101.22337972
46Complement and coagulation cascades_Homo sapiens_hsa046101.19019660
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15561604
48Arginine and proline metabolism_Homo sapiens_hsa003301.15035454
49Histidine metabolism_Homo sapiens_hsa003401.14525329
50Butanoate metabolism_Homo sapiens_hsa006501.14019886
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10421724
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08363116
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05245727
54Fructose and mannose metabolism_Homo sapiens_hsa000511.04454801
55Chemical carcinogenesis_Homo sapiens_hsa052041.03471373
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00215210
57Phenylalanine metabolism_Homo sapiens_hsa003600.97827977
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96645571
59Primary immunodeficiency_Homo sapiens_hsa053400.95587271
60Oxidative phosphorylation_Homo sapiens_hsa001900.94537089
61Parkinsons disease_Homo sapiens_hsa050120.94352949
62Glutathione metabolism_Homo sapiens_hsa004800.93911221
63PPAR signaling pathway_Homo sapiens_hsa033200.93253275
64Cell cycle_Homo sapiens_hsa041100.92108984
65RNA degradation_Homo sapiens_hsa030180.91882343
66Fatty acid metabolism_Homo sapiens_hsa012120.91343251
67Caffeine metabolism_Homo sapiens_hsa002320.91341003
68Purine metabolism_Homo sapiens_hsa002300.90905997
69Retinol metabolism_Homo sapiens_hsa008300.87371625
70Galactose metabolism_Homo sapiens_hsa000520.84961039
71Huntingtons disease_Homo sapiens_hsa050160.82800054
72Tyrosine metabolism_Homo sapiens_hsa003500.82218422
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82070164
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80532700
75Vitamin digestion and absorption_Homo sapiens_hsa049770.78143037
76Metabolic pathways_Homo sapiens_hsa011000.77929005
77Basal transcription factors_Homo sapiens_hsa030220.77181425
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76271328
79Fanconi anemia pathway_Homo sapiens_hsa034600.71978551
80Fat digestion and absorption_Homo sapiens_hsa049750.71958737
81Phototransduction_Homo sapiens_hsa047440.70670283
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.66741002
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.65873307
84Starch and sucrose metabolism_Homo sapiens_hsa005000.65606928
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61249829
86p53 signaling pathway_Homo sapiens_hsa041150.57250716
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57163949
88N-Glycan biosynthesis_Homo sapiens_hsa005100.52456096
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50874396
90Bile secretion_Homo sapiens_hsa049760.50566962
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49241687
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49068647
93Fatty acid elongation_Homo sapiens_hsa000620.49042136
94Regulation of autophagy_Homo sapiens_hsa041400.49038305
95Collecting duct acid secretion_Homo sapiens_hsa049660.47963114
96Protein export_Homo sapiens_hsa030600.44667413
97Sulfur metabolism_Homo sapiens_hsa009200.43409183
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41341896
99Systemic lupus erythematosus_Homo sapiens_hsa053220.40908607
100Glycerolipid metabolism_Homo sapiens_hsa005610.40006684
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38932814
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38342454
103Linoleic acid metabolism_Homo sapiens_hsa005910.37390106
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36669127
105Steroid biosynthesis_Homo sapiens_hsa001000.36378253
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36032853
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35726122
108Non-homologous end-joining_Homo sapiens_hsa034500.33482905
109Alzheimers disease_Homo sapiens_hsa050100.33345615
110ABC transporters_Homo sapiens_hsa020100.32944388
111mRNA surveillance pathway_Homo sapiens_hsa030150.32866644
112Lysine degradation_Homo sapiens_hsa003100.31801095
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31767152
114Epstein-Barr virus infection_Homo sapiens_hsa051690.29291943
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27715594
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26182493
117Staphylococcus aureus infection_Homo sapiens_hsa051500.24193697
118Oocyte meiosis_Homo sapiens_hsa041140.22619442

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