RPUSD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69368919
2maturation of SSU-rRNA (GO:0030490)4.78395621
3viral transcription (GO:0019083)4.72019279
4DNA deamination (GO:0045006)4.71276318
5maturation of 5.8S rRNA (GO:0000460)4.69519329
6muscle filament sliding (GO:0030049)4.67079742
7actin-myosin filament sliding (GO:0033275)4.67079742
8regulation of mitochondrial translation (GO:0070129)4.63073962
9translational termination (GO:0006415)4.62499672
10formation of translation preinitiation complex (GO:0001731)4.62069988
11ribosomal small subunit biogenesis (GO:0042274)4.42434991
12DNA strand elongation involved in DNA replication (GO:0006271)4.39747709
13translational elongation (GO:0006414)4.29436606
14nucleobase biosynthetic process (GO:0046112)4.24744577
15DNA strand elongation (GO:0022616)4.17175197
16purine nucleobase biosynthetic process (GO:0009113)4.12350854
17ribosomal large subunit biogenesis (GO:0042273)4.11770112
18telomere maintenance via semi-conservative replication (GO:0032201)4.10450032
19DNA replication initiation (GO:0006270)4.10344161
20ubiquinone biosynthetic process (GO:0006744)4.07940678
21translational initiation (GO:0006413)4.01179078
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.00371829
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.98687545
24ribonucleoprotein complex biogenesis (GO:0022613)3.88748018
25cotranslational protein targeting to membrane (GO:0006613)3.88368307
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.86084990
27protein targeting to ER (GO:0045047)3.85920727
28DNA replication checkpoint (GO:0000076)3.81875685
29ubiquinone metabolic process (GO:0006743)3.81702662
30actin-mediated cell contraction (GO:0070252)3.80816680
31DNA unwinding involved in DNA replication (GO:0006268)3.76753281
32telomere maintenance via recombination (GO:0000722)3.68437863
33ribosome biogenesis (GO:0042254)3.66858605
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65400188
35protein localization to endoplasmic reticulum (GO:0070972)3.64078488
36sarcoplasmic reticulum calcium ion transport (GO:0070296)3.62496152
37IMP biosynthetic process (GO:0006188)3.61425671
38viral life cycle (GO:0019058)3.59915398
39cellular protein complex disassembly (GO:0043624)3.59890887
40protein localization to kinetochore (GO:0034501)3.55013784
41mitochondrial RNA metabolic process (GO:0000959)3.49209291
42folic acid-containing compound biosynthetic process (GO:0009396)3.49084761
43regulation of skeletal muscle contraction (GO:0014819)3.46715406
44skeletal muscle contraction (GO:0003009)3.45939958
45mitochondrial respiratory chain complex assembly (GO:0033108)3.44567984
46CENP-A containing nucleosome assembly (GO:0034080)3.42474371
47mitotic metaphase plate congression (GO:0007080)3.39059132
48mitotic recombination (GO:0006312)3.38514513
49ribosome assembly (GO:0042255)3.38196593
50rRNA processing (GO:0006364)3.37564256
51protein complex biogenesis (GO:0070271)3.37125459
52oxidative phosphorylation (GO:0006119)3.32323490
53chromatin remodeling at centromere (GO:0031055)3.29900040
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26922920
55IMP metabolic process (GO:0046040)3.25521633
56spliceosomal snRNP assembly (GO:0000387)3.24094060
57rRNA metabolic process (GO:0016072)3.24086817
58cytochrome complex assembly (GO:0017004)3.24070903
59mitotic nuclear envelope disassembly (GO:0007077)3.24065652
60telomere maintenance via telomere lengthening (GO:0010833)3.23108933
61attachment of spindle microtubules to kinetochore (GO:0008608)3.22718052
62quinone biosynthetic process (GO:1901663)3.21939408
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21771759
64proteasome assembly (GO:0043248)3.21489946
65regulation of relaxation of muscle (GO:1901077)3.20942321
66protein complex disassembly (GO:0043241)3.20876125
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19907504
68translation (GO:0006412)3.19750647
69rRNA modification (GO:0000154)3.19466848
70negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.16159816
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.14617707
72cullin deneddylation (GO:0010388)3.14399245
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14390807
74transcription from mitochondrial promoter (GO:0006390)3.13122351
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12489436
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.12489436
77NADH dehydrogenase complex assembly (GO:0010257)3.12489436
78chaperone-mediated protein transport (GO:0072321)3.11481877
79DNA replication-independent nucleosome organization (GO:0034724)3.11217456
80DNA replication-independent nucleosome assembly (GO:0006336)3.11217456
81* pseudouridine synthesis (GO:0001522)3.08732445
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.06730673
83macromolecular complex disassembly (GO:0032984)3.05535936
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03778580
85aspartate family amino acid catabolic process (GO:0009068)3.03527333
86cellular component biogenesis (GO:0044085)3.03045619
87respiratory chain complex IV assembly (GO:0008535)3.02011693
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01077684
89protein deneddylation (GO:0000338)3.00532438
90mRNA catabolic process (GO:0006402)2.99363209
91DNA replication-dependent nucleosome assembly (GO:0006335)2.98927287
92DNA replication-dependent nucleosome organization (GO:0034723)2.98927287
93metaphase plate congression (GO:0051310)2.98593479
94protein localization to chromosome, centromeric region (GO:0071459)2.97672269
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96156556
96transcription-coupled nucleotide-excision repair (GO:0006283)2.95794703
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93430618
98nuclear envelope disassembly (GO:0051081)2.93058808
99membrane disassembly (GO:0030397)2.93058808
100RNA catabolic process (GO:0006401)2.92572893
101folic acid metabolic process (GO:0046655)2.92308095
102DNA double-strand break processing (GO:0000729)2.91854396
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88853544
104somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87295017
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.87295017
106ATP synthesis coupled proton transport (GO:0015986)2.87285071
107energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87285071
108termination of RNA polymerase III transcription (GO:0006386)2.87270735
109transcription elongation from RNA polymerase III promoter (GO:0006385)2.87270735
110establishment of integrated proviral latency (GO:0075713)2.87155217
111G1/S transition of mitotic cell cycle (GO:0000082)2.87044998
112cell cycle G1/S phase transition (GO:0044843)2.87044998
113negative regulation of ligase activity (GO:0051352)2.82217706
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82217706
115peptidyl-histidine modification (GO:0018202)2.81869883
116tRNA methylation (GO:0030488)2.81613527
117creatine metabolic process (GO:0006600)2.80560259
118AMP metabolic process (GO:0046033)2.79955830
119RNA localization (GO:0006403)2.79893013
120establishment of chromosome localization (GO:0051303)2.79078593
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78483444
122somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77537954
123isotype switching (GO:0045190)2.77537954
124somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77537954
125regulation of spindle organization (GO:0090224)2.77499382
126kinetochore organization (GO:0051383)2.76580329
127inner mitochondrial membrane organization (GO:0007007)2.75435431
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75230959
129lysine metabolic process (GO:0006553)2.74315372
130lysine catabolic process (GO:0006554)2.74315372
131tricarboxylic acid cycle (GO:0006099)2.73344216
132respiratory electron transport chain (GO:0022904)2.73315572
133signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73285908
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73285908
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70914152
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70369530
137signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70369530
138signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70369530
139mitotic chromosome condensation (GO:0007076)2.68871274
140electron transport chain (GO:0022900)2.68739770
141histone exchange (GO:0043486)2.68736912
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67500591
143amino acid activation (GO:0043038)2.67368868
144tRNA aminoacylation (GO:0043039)2.67368868
145mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66931073
146rRNA methylation (GO:0031167)2.66922749
147viral mRNA export from host cell nucleus (GO:0046784)2.66698128
148protein targeting to mitochondrion (GO:0006626)2.66516024
149signal transduction involved in DNA damage checkpoint (GO:0072422)2.65629123
150signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65629123
151DNA catabolic process, exonucleolytic (GO:0000738)2.65467917
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.65465384
153positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.65089399
154ncRNA metabolic process (GO:0034660)2.64799278
1557-methylguanosine mRNA capping (GO:0006370)2.64649989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01930078
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.18580075
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78274085
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05927146
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.05517990
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00907617
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.00469256
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91793626
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.89163311
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82922673
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.81456910
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80453304
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72684481
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63515705
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61449253
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61260795
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31314895
18VDR_23849224_ChIP-Seq_CD4+_Human2.30248406
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28745738
20XRN2_22483619_ChIP-Seq_HELA_Human2.28522833
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18323046
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13238416
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10574471
24FOXP3_21729870_ChIP-Seq_TREG_Human2.10449999
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06155914
26DCP1A_22483619_ChIP-Seq_HELA_Human2.04360237
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00358449
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96390053
29* GABP_19822575_ChIP-Seq_HepG2_Human1.88976107
30MYC_22102868_ChIP-Seq_BL_Human1.87735463
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86547212
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82658326
33TTF2_22483619_ChIP-Seq_HELA_Human1.81428285
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75631931
35AR_21909140_ChIP-Seq_LNCAP_Human1.73620287
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.73071759
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72318592
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.71555983
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69469477
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69316445
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.69156210
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68683126
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64741824
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.64496645
45* YY1_21170310_ChIP-Seq_MESCs_Mouse1.64485852
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61244941
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61158844
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60662523
49* CIITA_25753668_ChIP-Seq_RAJI_Human1.60058444
50ELK1_19687146_ChIP-ChIP_HELA_Human1.58844591
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57785840
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54491375
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54458703
54ZNF274_21170338_ChIP-Seq_K562_Hela1.52729790
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49580302
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47192669
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47136260
58IGF1R_20145208_ChIP-Seq_DFB_Human1.42510882
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41211836
60* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41029193
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39948444
62KDM5A_27292631_Chip-Seq_BREAST_Human1.38303210
63VDR_22108803_ChIP-Seq_LS180_Human1.37039822
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36028617
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.34290109
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32726292
67VDR_21846776_ChIP-Seq_THP-1_Human1.31532870
68SPI1_23547873_ChIP-Seq_NB4_Human1.31417689
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30807720
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20898082
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19330951
72* TFEB_21752829_ChIP-Seq_HELA_Human1.17973818
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17855280
74IRF1_19129219_ChIP-ChIP_H3396_Human1.17448375
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15381433
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15112560
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.13265584
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11093627
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10785917
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07979359
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07934454
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06705139
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03340447
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03264149
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02946229
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.02222194
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02183975
88MYC_18940864_ChIP-ChIP_HL60_Human1.02124835
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00248527
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00203071
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96380818
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96194405
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96062801
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94758988
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92576951
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92517358
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92159671
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91825520
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.91662815
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90313045
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.90077524
102MYB_26560356_Chip-Seq_TH2_Human0.88189935
103IRF8_21731497_ChIP-ChIP_J774_Mouse0.88144778
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.87263008
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86609990
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86229946
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86221971
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85013091
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84608780
110MYB_26560356_Chip-Seq_TH1_Human0.83108491
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82485149
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82020016
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80244012
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.76918103
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75448199
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73511897
117EWS_26573619_Chip-Seq_HEK293_Human0.73433711
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72795810
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71464399
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.71285349
121FUS_26573619_Chip-Seq_HEK293_Human0.68741425
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.66861490
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.66291338
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64428532
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.63578665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.85981534
2MP0003693_abnormal_embryo_hatching5.42013664
3MP0004145_abnormal_muscle_electrophysio4.80039547
4MP0010094_abnormal_chromosome_stability3.94855010
5MP0004957_abnormal_blastocyst_morpholog3.76140611
6MP0003077_abnormal_cell_cycle3.54642226
7MP0003111_abnormal_nucleus_morphology3.53324294
8MP0000749_muscle_degeneration3.38517811
9MP0008057_abnormal_DNA_replication3.27557542
10MP0008058_abnormal_DNA_repair3.17619932
11MP0000751_myopathy2.79631165
12MP0002396_abnormal_hematopoietic_system2.78342980
13MP0008007_abnormal_cellular_replicative2.73626185
14MP0004147_increased_porphyrin_level2.42964587
15MP0002837_dystrophic_cardiac_calcinosis2.39945724
16MP0003763_abnormal_thymus_physiology2.37336939
17MP0009333_abnormal_splenocyte_physiolog2.21449263
18MP0002106_abnormal_muscle_physiology2.20808855
19MP0004036_abnormal_muscle_relaxation2.19440125
20MP0003806_abnormal_nucleotide_metabolis2.17009806
21MP0008932_abnormal_embryonic_tissue2.16542230
22MP0006292_abnormal_olfactory_placode2.10878579
23MP0001835_abnormal_antigen_presentation1.99493379
24MP0004233_abnormal_muscle_weight1.91407768
25MP0004808_abnormal_hematopoietic_stem1.90761851
26MP0001730_embryonic_growth_arrest1.90106677
27MP0005671_abnormal_response_to1.86460439
28MP0002269_muscular_atrophy1.84591381
29MP0005369_muscle_phenotype1.82618897
30MP0000490_abnormal_crypts_of1.81970866
31MP0000759_abnormal_skeletal_muscle1.81240326
32MP0002398_abnormal_bone_marrow1.79205969
33MP0000372_irregular_coat_pigmentation1.78418624
34MP0004087_abnormal_muscle_fiber1.76999516
35MP0009697_abnormal_copulation1.75044549
36MP0000350_abnormal_cell_proliferation1.74128476
37MP0001853_heart_inflammation1.69086859
38MP0000689_abnormal_spleen_morphology1.68809999
39MP0001661_extended_life_span1.65621220
40MP0002722_abnormal_immune_system1.65040501
41MP0003786_premature_aging1.62682182
42MP0000747_muscle_weakness1.62641540
43MP0004084_abnormal_cardiac_muscle1.62367454
44MP0001800_abnormal_humoral_immune1.59699669
45MP0000685_abnormal_immune_system1.57367909
46MP0002019_abnormal_tumor_incidence1.56398875
47MP0005330_cardiomyopathy1.55791114
48MP0003718_maternal_effect1.54291514
49MP0009785_altered_susceptibility_to1.52639691
50MP0008995_early_reproductive_senescence1.51895737
51MP0002254_reproductive_system_inflammat1.51796980
52MP0005451_abnormal_body_composition1.50992458
53MP0000703_abnormal_thymus_morphology1.50842631
54MP0003186_abnormal_redox_activity1.50592396
55MP0000750_abnormal_muscle_regeneration1.48695371
56MP0010352_gastrointestinal_tract_polyps1.48304984
57MP0008877_abnormal_DNA_methylation1.47345563
58MP0002429_abnormal_blood_cell1.46096528
59MP0005397_hematopoietic_system_phenotyp1.44063158
60MP0001545_abnormal_hematopoietic_system1.44063158
61MP0000716_abnormal_immune_system1.43467610
62MP0004215_abnormal_myocardial_fiber1.43371641
63MP0002420_abnormal_adaptive_immunity1.43087657
64MP0001819_abnormal_immune_cell1.40929644
65MP0003123_paternal_imprinting1.40917211
66MP0001697_abnormal_embryo_size1.40724533
67MP0002132_abnormal_respiratory_system1.40461394
68MP0002452_abnormal_antigen_presenting1.39897578
69MP0000313_abnormal_cell_death1.38865450
70MP0005380_embryogenesis_phenotype1.38065381
71MP0001672_abnormal_embryogenesis/_devel1.38065381
72MP0002723_abnormal_immune_serum1.33272322
73MP0002080_prenatal_lethality1.33147449
74MP0005620_abnormal_muscle_contractility1.32551537
75MP0006036_abnormal_mitochondrial_physio1.30185595
76MP0002163_abnormal_gland_morphology1.30101537
77MP0005025_abnormal_response_to1.26381961
78MP0008789_abnormal_olfactory_epithelium1.25800861
79MP0003567_abnormal_fetal_cardiomyocyte1.25614394
80MP0003984_embryonic_growth_retardation1.24789222
81MP0002405_respiratory_system_inflammati1.23499325
82MP0000858_altered_metastatic_potential1.22409338
83MP0002088_abnormal_embryonic_growth/wei1.21024696
84MP0005000_abnormal_immune_tolerance1.16610189
85MP0003436_decreased_susceptibility_to1.13066999
86MP0010307_abnormal_tumor_latency1.10917785
87MP0002086_abnormal_extraembryonic_tissu1.07007937
88MP0005379_endocrine/exocrine_gland_phen1.06507664
89MP0009672_abnormal_birth_weight1.06201223
90MP0010155_abnormal_intestine_physiology1.02128950
91MP0001790_abnormal_immune_system1.00625270
92MP0005387_immune_system_phenotype1.00625270
93MP0002419_abnormal_innate_immunity0.97758247
94MP0005075_abnormal_melanosome_morpholog0.97430068
95MP0003950_abnormal_plasma_membrane0.95321574
96MP0002148_abnormal_hypersensitivity_rea0.95152303
97MP0002938_white_spotting0.95016875
98MP0009379_abnormal_foot_pigmentation0.94438149
99MP0005645_abnormal_hypothalamus_physiol0.94151225
100MP0002972_abnormal_cardiac_muscle0.93558175
101MP0005332_abnormal_amino_acid0.93387615
102MP0004142_abnormal_muscle_tone0.93219157
103MP0001873_stomach_inflammation0.91630321
104MP0002085_abnormal_embryonic_tissue0.91174054
105MP0001845_abnormal_inflammatory_respons0.91104050
106MP0001764_abnormal_homeostasis0.90150664
107MP0005023_abnormal_wound_healing0.89066615
108MP0003941_abnormal_skin_development0.88075538
109MP0003315_abnormal_perineum_morphology0.87973201
110MP0005084_abnormal_gallbladder_morpholo0.87115033
111MP0006035_abnormal_mitochondrial_morpho0.87071800
112MP0002210_abnormal_sex_determination0.86724961
113MP0000358_abnormal_cell_content/0.86101861
114MP0009840_abnormal_foam_cell0.84964917
115MP0003221_abnormal_cardiomyocyte_apopto0.84528994
116MP0003136_yellow_coat_color0.84524972
117MP0005464_abnormal_platelet_physiology0.84269890
118MP0000733_abnormal_muscle_development0.84229415
119MP0006072_abnormal_retinal_apoptosis0.83839940
120MP0003137_abnormal_impulse_conducting0.82854099
121MP0008775_abnormal_heart_ventricle0.81647118
122MP0001119_abnormal_female_reproductive0.81567755
123MP0001544_abnormal_cardiovascular_syste0.80114401
124MP0005385_cardiovascular_system_phenoty0.80114401
125MP0000465_gastrointestinal_hemorrhage0.79704741
126MP0002332_abnormal_exercise_endurance0.78659806
127MP0001145_abnormal_male_reproductive0.78404465
128MP0002108_abnormal_muscle_morphology0.78283162
129MP0002084_abnormal_developmental_patter0.77781630
130MP0003943_abnormal_hepatobiliary_system0.77679707
131MP0004484_altered_response_of0.76940500
132MP0005266_abnormal_metabolism0.76722743
133MP0004197_abnormal_fetal_growth/weight/0.75855197
134MP0004130_abnormal_muscle_cell0.72916418
135MP0000653_abnormal_sex_gland0.71880811
136MP0008872_abnormal_physiological_respon0.71264636
137MP0001929_abnormal_gametogenesis0.71263409
138MP0002102_abnormal_ear_morphology0.71173434
139MP0003121_genomic_imprinting0.70076170
140MP0006054_spinal_hemorrhage0.70016828
141MP0008469_abnormal_protein_level0.69711948
142MP0002127_abnormal_cardiovascular_syste0.68994349
143MP0005384_cellular_phenotype0.68599938
144MP0005621_abnormal_cell_physiology0.68399539
145MP0005076_abnormal_cell_differentiation0.67962608
146MP0000598_abnormal_liver_morphology0.67852957
147MP0005389_reproductive_system_phenotype0.66656999
148MP0003866_abnormal_defecation0.66194958
149MP0005395_other_phenotype0.64378547
150MP0000477_abnormal_intestine_morphology0.63571959
151MP0001919_abnormal_reproductive_system0.62608725
152MP0000343_altered_response_to0.62173031
153MP0010630_abnormal_cardiac_muscle0.61752884
154MP0002234_abnormal_pharynx_morphology0.61474842
155MP0002160_abnormal_reproductive_system0.61136873
156MP0001986_abnormal_taste_sensitivity0.60763330
157MP0001529_abnormal_vocalization0.60474275
158MP0005083_abnormal_biliary_tract0.60279056
159MP0001293_anophthalmia0.60211728
160MP0001915_intracranial_hemorrhage0.60005087
161MP0003698_abnormal_male_reproductive0.56029368

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)7.48932823
2Muscle fiber inclusion bodies (HP:0100299)7.36068985
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.13221195
4Exercise-induced muscle cramps (HP:0003710)5.34131104
5Abnormality of cells of the erythroid lineage (HP:0012130)5.04559598
6Reticulocytopenia (HP:0001896)4.97885099
7Exercise-induced myalgia (HP:0003738)4.93071122
8Abnormal number of erythroid precursors (HP:0012131)4.75149553
9Birth length less than 3rd percentile (HP:0003561)4.50229912
10Type 1 muscle fiber predominance (HP:0003803)4.21131735
11Muscle hypertrophy of the lower extremities (HP:0008968)4.01520673
12Aplastic anemia (HP:0001915)3.71560072
13Myoglobinuria (HP:0002913)3.70468764
14Calf muscle hypertrophy (HP:0008981)3.68691964
15Myopathic facies (HP:0002058)3.67733157
16Rhabdomyolysis (HP:0003201)3.55527897
17Distal arthrogryposis (HP:0005684)3.54655385
18Thrombocytosis (HP:0001894)3.51461943
19Macrocytic anemia (HP:0001972)3.33084907
20Acute necrotizing encephalopathy (HP:0006965)3.23693508
21IgM deficiency (HP:0002850)3.22678193
22Breast hypoplasia (HP:0003187)3.22202205
23Pallor (HP:0000980)3.18944299
24Degeneration of anterior horn cells (HP:0002398)3.18529386
25Abnormality of the anterior horn cell (HP:0006802)3.18529386
26Acute encephalopathy (HP:0006846)3.16908973
27Rimmed vacuoles (HP:0003805)3.13599781
28Microretrognathia (HP:0000308)3.09753915
29Abnormal mitochondria in muscle tissue (HP:0008316)3.02574800
30EMG: myopathic abnormalities (HP:0003458)3.01854157
31Oral leukoplakia (HP:0002745)2.98883182
32Ulnar deviation of the wrist (HP:0003049)2.96237861
33Colon cancer (HP:0003003)2.90997384
34Muscle stiffness (HP:0003552)2.80396966
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.74312683
36Exercise intolerance (HP:0003546)2.72384221
37Neck muscle weakness (HP:0000467)2.72361280
38Multiple enchondromatosis (HP:0005701)2.68561594
39Progressive macrocephaly (HP:0004481)2.65639138
40Agnosia (HP:0010524)2.64824738
41Chromsome breakage (HP:0040012)2.64428036
42Abnormality of the calf musculature (HP:0001430)2.64209344
43Selective tooth agenesis (HP:0001592)2.61926314
44Myelodysplasia (HP:0002863)2.61484842
45Absent phalangeal crease (HP:0006109)2.61138219
46Hyperglycinuria (HP:0003108)2.59879349
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56152748
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56152748
49Exertional dyspnea (HP:0002875)2.52639896
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49660689
51Increased serum lactate (HP:0002151)2.47008162
52Absent thumb (HP:0009777)2.45990407
53Abnormality of alanine metabolism (HP:0010916)2.43923569
54Hyperalaninemia (HP:0003348)2.43923569
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43923569
56Calcaneovalgus deformity (HP:0001848)2.43796813
5711 pairs of ribs (HP:0000878)2.43400076
58Rough bone trabeculation (HP:0100670)2.42228886
59Abnormality of the preputium (HP:0100587)2.41807468
60Amaurosis fugax (HP:0100576)2.39354920
61Type I transferrin isoform profile (HP:0003642)2.38373254
62T lymphocytopenia (HP:0005403)2.37930546
63Abnormality of chromosome stability (HP:0003220)2.37186614
64Hepatocellular necrosis (HP:0001404)2.35319177
65Meckel diverticulum (HP:0002245)2.35144599
66Abnormality of T cells (HP:0002843)2.34992866
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34770911
68Lymphoma (HP:0002665)2.34309938
69Cerebral edema (HP:0002181)2.33023806
70Malignant hyperthermia (HP:0002047)2.32541216
71Abnormal finger flexion creases (HP:0006143)2.31874868
72Hepatic necrosis (HP:0002605)2.31658146
73Increased muscle lipid content (HP:0009058)2.31012018
74Medulloblastoma (HP:0002885)2.30952773
75Bone marrow hypocellularity (HP:0005528)2.29978001
76Combined immunodeficiency (HP:0005387)2.29243963
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.28791994
78Patellar aplasia (HP:0006443)2.28557546
79Increased serum pyruvate (HP:0003542)2.25837335
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24759907
81Basal cell carcinoma (HP:0002671)2.24161911
82Abnormality of glycine metabolism (HP:0010895)2.23105056
83Abnormality of serine family amino acid metabolism (HP:0010894)2.23105056
84Abnormality of the ileum (HP:0001549)2.21961947
85Abnormality of T cell number (HP:0011839)2.19408658
86Deformed tarsal bones (HP:0008119)2.19100423
87Abnormality of the labia minora (HP:0012880)2.18671165
88Respiratory difficulties (HP:0002880)2.18114804
89Premature graying of hair (HP:0002216)2.17465671
90Areflexia of lower limbs (HP:0002522)2.15834644
91Elevated erythrocyte sedimentation rate (HP:0003565)2.14137968
92Aplasia/Hypoplasia of the patella (HP:0006498)2.12417922
93Increased hepatocellular lipid droplets (HP:0006565)2.11777135
94Pancytopenia (HP:0001876)2.11508298
953-Methylglutaconic aciduria (HP:0003535)2.10192181
96Severe combined immunodeficiency (HP:0004430)2.06055601
97Increased CSF lactate (HP:0002490)2.05650847
98Hyperglycinemia (HP:0002154)2.05509832
99Cellular immunodeficiency (HP:0005374)2.05482216
100Abnormality of pyrimidine metabolism (HP:0004353)2.04431696
101Premature ovarian failure (HP:0008209)2.03592300
102Carpal bone hypoplasia (HP:0001498)2.03185199
103Chronic otitis media (HP:0000389)2.02483290
104IgG deficiency (HP:0004315)2.01727729
105Round ear (HP:0100830)2.00755708
106Abnormality of reticulocytes (HP:0004312)2.00039341
107Lipid accumulation in hepatocytes (HP:0006561)1.99960422
108Abnormality of glycolysis (HP:0004366)1.99939914
109Cerebral hypomyelination (HP:0006808)1.99916912
110Petechiae (HP:0000967)1.97874006
111Abnormal lung lobation (HP:0002101)1.97344767
112Duodenal stenosis (HP:0100867)1.96214304
113Small intestinal stenosis (HP:0012848)1.96214304
114Poor head control (HP:0002421)1.95692755
115Respiratory failure (HP:0002878)1.92169568
116Recurrent viral infections (HP:0004429)1.91729229
117Mitochondrial inheritance (HP:0001427)1.91552481
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91441165
119Type 2 muscle fiber atrophy (HP:0003554)1.91104099
120Abnormality of B cell number (HP:0010975)1.91103958
121B lymphocytopenia (HP:0010976)1.91103958
122Muscle fiber splitting (HP:0003555)1.90865110
123Ependymoma (HP:0002888)1.90796260
124Abnormality of serum amino acid levels (HP:0003112)1.90090806
125Generalized muscle weakness (HP:0003324)1.89846563
126Neoplasm of the pancreas (HP:0002894)1.89685792
127Squamous cell carcinoma (HP:0002860)1.89222787
128Abnormality of T cell physiology (HP:0011840)1.87952717
129Neoplasm of the adrenal gland (HP:0100631)1.87764982
130Myotonia (HP:0002486)1.87322210
131Subaortic stenosis (HP:0001682)1.85352749
132Abnormality of the left ventricular outflow tract (HP:0011103)1.85352749
133Recurrent bronchitis (HP:0002837)1.84503100
134Poikiloderma (HP:0001029)1.83316484
135Pancreatic islet-cell hyperplasia (HP:0004510)1.83237750
136Methylmalonic acidemia (HP:0002912)1.82883268
137Recurrent abscess formation (HP:0002722)1.82064005
138Limb-girdle muscle atrophy (HP:0003797)1.81592365
139Microvesicular hepatic steatosis (HP:0001414)1.80986806
140Reduced antithrombin III activity (HP:0001976)1.80353636
141Sloping forehead (HP:0000340)1.79565958
142Lymphopenia (HP:0001888)1.77959215
143Rhabdomyosarcoma (HP:0002859)1.77827862
144Mediastinal lymphadenopathy (HP:0100721)1.77816413
145Missing ribs (HP:0000921)1.77620210
146Sudden death (HP:0001699)1.77580243
147Lethargy (HP:0001254)1.77238624
148Methylmalonic aciduria (HP:0012120)1.76753851
149Lactic acidosis (HP:0003128)1.76579394
150Pendular nystagmus (HP:0012043)1.76067206
151Increased intramyocellular lipid droplets (HP:0012240)1.75242854
152Renal cortical cysts (HP:0000803)1.75238095
153Progressive muscle weakness (HP:0003323)1.75043283
154Abnormality of cells of the lymphoid lineage (HP:0012140)1.74997086
155Acute myeloid leukemia (HP:0004808)1.73490940
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73482367
157Dicarboxylic aciduria (HP:0003215)1.73482367
158Abnormality of the duodenum (HP:0002246)1.73310050
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73139259
160Abnormal protein N-linked glycosylation (HP:0012347)1.73139259
161Abnormal protein glycosylation (HP:0012346)1.73139259
162Abnormal glycosylation (HP:0012345)1.73139259
163Type II lissencephaly (HP:0007260)1.73091113
164Supernumerary spleens (HP:0009799)1.72720346
165Muscle fiber atrophy (HP:0100295)1.66474405
166Optic disc pallor (HP:0000543)1.64123001
167Prominent metopic ridge (HP:0005487)1.63623915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.89946884
2BUB14.10584952
3WEE13.60559229
4PHKG13.41482906
5PHKG23.41482906
6VRK23.27660011
7ZAK3.17676348
8NME23.13182114
9CDC73.06557159
10MAP4K12.51259241
11STK162.37918153
12EIF2AK12.35474052
13ACVR1B2.20255254
14TSSK62.15102229
15NEK22.14487708
16TESK21.97453361
17SRPK11.93394147
18PBK1.84386589
19VRK11.82804935
20BRSK21.82564314
21FLT31.81165947
22PIM21.79290372
23NUAK11.73764640
24TTN1.72458810
25MAP2K31.71036094
26PLK41.70739706
27PASK1.64880847
28EIF2AK31.61038666
29BCKDK1.59391505
30BMPR1B1.56733882
31TGFBR11.54395797
32STK101.50269496
33PLK11.49219267
34TAF11.46754979
35RIPK11.46061937
36TTK1.43196418
37RPS6KB21.41797012
38NEK11.40303186
39BLK1.38297996
40WNK31.35577008
41TRIM281.32764122
42TXK1.32633809
43ARAF1.32128086
44EEF2K1.30065515
45AURKB1.29019721
46STK38L1.28848402
47PINK11.27760927
48ZAP701.27065798
49CDK71.26049237
50MAP3K111.25105017
51LRRK21.23131231
52ATR1.22869711
53TAOK21.21662107
54MAP4K21.20645303
55GRK61.18868830
56BTK1.15645867
57MST41.12779677
58KIT1.12281449
59MAP3K81.12037105
60MKNK11.11820103
61PKN21.09011524
62TEC1.08990180
63RPS6KA41.06407498
64JAK31.05691535
65CCNB11.05404979
66PIM11.05315042
67PDK21.04304121
68KDR1.02758453
69SCYL21.00530068
70TIE10.98269601
71STK40.97978694
72PLK30.97628668
73NLK0.95000894
74BRSK10.94860854
75PIK3CG0.94353038
76TLK10.92188964
77CDK190.90168801
78MAPKAPK30.89781481
79FRK0.89215654
80CDK40.89157977
81AURKA0.88911312
82MUSK0.88790027
83MAP3K30.88182646
84DYRK30.87085395
85BRAF0.85448840
86TNIK0.84503957
87ITK0.82557481
88TYK20.80946613
89CSF1R0.79796687
90CHEK10.79246707
91RAF10.77966042
92MAP3K100.75329417
93PAK40.72132468
94TAOK30.70101749
95TAOK10.67046522
96MKNK20.63531648
97GRK10.63252441
98MOS0.62660146
99CSNK2A20.62280777
100CSNK2A10.62190596
101STK30.61830436
102STK240.61745319
103CHEK20.60880247
104CSNK1G10.58756069
105SYK0.58323242
106IKBKB0.58044699
107ILK0.56430189
108EIF2AK20.56205774
109CDK80.56157373
110MAPKAPK50.55760701
111IRAK40.55719035
112PRKCI0.55595541
113ADRBK20.55510192
114OXSR10.55108999
115MAP3K50.52408756
116DAPK10.52380266
117LCK0.52197707
118LYN0.51971402
119TBK10.51405075
120EPHA20.47514183
121CDK20.47052783
122AKT20.46693308
123CSNK1G30.46415675
124TRIB30.45942723
125MAPK110.45666000
126NEK90.44445640
127ATM0.43955103
128MAP2K60.43781836
129CLK10.42452300
130PAK10.41259341
131MELK0.39050126
132CSNK1E0.38394580
133NME10.38096310
134CDK10.37127153
135DAPK30.36333673
136PRKAA20.36186004
137ERBB30.35586893
138MAP3K40.32636566
139RPS6KC10.31194972
140RPS6KL10.31194972
141MAPK120.30179841
142PNCK0.29183132
143PRKDC0.28831108
144INSRR0.26454051
145LATS10.25538580

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67658294
2Ribosome_Homo sapiens_hsa030104.21867491
3Mismatch repair_Homo sapiens_hsa034303.85011045
4Proteasome_Homo sapiens_hsa030503.43326967
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35659175
6RNA polymerase_Homo sapiens_hsa030203.24461134
7Base excision repair_Homo sapiens_hsa034103.24039787
8Spliceosome_Homo sapiens_hsa030402.85643523
9Homologous recombination_Homo sapiens_hsa034402.69518598
10RNA transport_Homo sapiens_hsa030132.67149935
11Nucleotide excision repair_Homo sapiens_hsa034202.56593193
12Pyrimidine metabolism_Homo sapiens_hsa002402.48173930
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29150208
14One carbon pool by folate_Homo sapiens_hsa006702.25868074
15Cell cycle_Homo sapiens_hsa041102.13372636
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99506073
17Propanoate metabolism_Homo sapiens_hsa006401.95870108
18RNA degradation_Homo sapiens_hsa030181.92406098
19Fanconi anemia pathway_Homo sapiens_hsa034601.79265419
20Non-homologous end-joining_Homo sapiens_hsa034501.77486064
21Cardiac muscle contraction_Homo sapiens_hsa042601.71541183
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71482861
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69194532
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61151683
25Fatty acid elongation_Homo sapiens_hsa000621.59574963
26Basal transcription factors_Homo sapiens_hsa030221.55691436
27Primary immunodeficiency_Homo sapiens_hsa053401.51756649
28Fatty acid metabolism_Homo sapiens_hsa012121.35015139
29Alzheimers disease_Homo sapiens_hsa050101.34078785
30p53 signaling pathway_Homo sapiens_hsa041151.32920911
31Purine metabolism_Homo sapiens_hsa002301.27960543
32mRNA surveillance pathway_Homo sapiens_hsa030151.24572870
33Epstein-Barr virus infection_Homo sapiens_hsa051691.23336630
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20802005
35Antigen processing and presentation_Homo sapiens_hsa046121.17629581
36Folate biosynthesis_Homo sapiens_hsa007901.09477024
37Fatty acid degradation_Homo sapiens_hsa000711.06738158
38Herpes simplex infection_Homo sapiens_hsa051681.05952438
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05360928
40Butanoate metabolism_Homo sapiens_hsa006501.03766334
41Pentose phosphate pathway_Homo sapiens_hsa000300.99474221
42Arginine and proline metabolism_Homo sapiens_hsa003300.98357489
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96900884
44Biosynthesis of amino acids_Homo sapiens_hsa012300.94800405
45Protein export_Homo sapiens_hsa030600.94612739
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.92801911
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88305361
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88114712
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.88105294
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.88012530
51Peroxisome_Homo sapiens_hsa041460.87676882
52Legionellosis_Homo sapiens_hsa051340.86789669
53Lysine degradation_Homo sapiens_hsa003100.85911672
54Selenocompound metabolism_Homo sapiens_hsa004500.85502322
55Tryptophan metabolism_Homo sapiens_hsa003800.84952493
56Parkinsons disease_Homo sapiens_hsa050120.83165334
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.79894810
58Carbon metabolism_Homo sapiens_hsa012000.78994586
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77451843
60Measles_Homo sapiens_hsa051620.75117480
61Huntingtons disease_Homo sapiens_hsa050160.73771554
62Sulfur relay system_Homo sapiens_hsa041220.72239491
63Galactose metabolism_Homo sapiens_hsa000520.68627937
64Nitrogen metabolism_Homo sapiens_hsa009100.67611296
65Thyroid cancer_Homo sapiens_hsa052160.67531873
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.65096023
67Vitamin B6 metabolism_Homo sapiens_hsa007500.63793569
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61936494
69Tyrosine metabolism_Homo sapiens_hsa003500.59975116
70Viral carcinogenesis_Homo sapiens_hsa052030.59954218
71Sulfur metabolism_Homo sapiens_hsa009200.59721536
72Systemic lupus erythematosus_Homo sapiens_hsa053220.57787493
73HTLV-I infection_Homo sapiens_hsa051660.56952145
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56184380
75Hematopoietic cell lineage_Homo sapiens_hsa046400.55856348
76Glutathione metabolism_Homo sapiens_hsa004800.55480596
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54721229
78Regulation of autophagy_Homo sapiens_hsa041400.54212356
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53807980
80Oxidative phosphorylation_Homo sapiens_hsa001900.53325582
81Fructose and mannose metabolism_Homo sapiens_hsa000510.53277021
82Arginine biosynthesis_Homo sapiens_hsa002200.52854355
83Allograft rejection_Homo sapiens_hsa053300.52734893
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52026280
85Apoptosis_Homo sapiens_hsa042100.51255996
86Oocyte meiosis_Homo sapiens_hsa041140.51109245
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51087021
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49886498
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48550497
90Leishmaniasis_Homo sapiens_hsa051400.48448548
91Steroid biosynthesis_Homo sapiens_hsa001000.47950756
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46780152
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46592072
94Influenza A_Homo sapiens_hsa051640.45519872
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44133241
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44020280
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43393643
98Shigellosis_Homo sapiens_hsa051310.42604994
99beta-Alanine metabolism_Homo sapiens_hsa004100.40614876
100Glucagon signaling pathway_Homo sapiens_hsa049220.40233583
101Acute myeloid leukemia_Homo sapiens_hsa052210.39864630
102N-Glycan biosynthesis_Homo sapiens_hsa005100.39537843
103Graft-versus-host disease_Homo sapiens_hsa053320.38881145
104Phototransduction_Homo sapiens_hsa047440.38386050
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35982693
106Viral myocarditis_Homo sapiens_hsa054160.35604988
107B cell receptor signaling pathway_Homo sapiens_hsa046620.33730109
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31708920
109Hepatitis B_Homo sapiens_hsa051610.31395942
110Other glycan degradation_Homo sapiens_hsa005110.31355758
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.30976220
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30533117
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29106123
114Metabolic pathways_Homo sapiens_hsa011000.28818481
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28784364
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28707098
117HIF-1 signaling pathway_Homo sapiens_hsa040660.27739200
118Small cell lung cancer_Homo sapiens_hsa052220.26754603
119Circadian rhythm_Homo sapiens_hsa047100.26272861
120Dilated cardiomyopathy_Homo sapiens_hsa054140.26252270
121T cell receptor signaling pathway_Homo sapiens_hsa046600.24797041
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23840492
123Pyruvate metabolism_Homo sapiens_hsa006200.23731122
124Linoleic acid metabolism_Homo sapiens_hsa005910.23096995
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21621926
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20081792
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18846977
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18364212
129Arachidonic acid metabolism_Homo sapiens_hsa005900.18219565
130Toxoplasmosis_Homo sapiens_hsa051450.17083169
131Colorectal cancer_Homo sapiens_hsa052100.16895223
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16198563
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15556313
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.15398122
135Insulin resistance_Homo sapiens_hsa049310.15271383
136Fatty acid biosynthesis_Homo sapiens_hsa000610.15232589
137Olfactory transduction_Homo sapiens_hsa047400.14053086
138Starch and sucrose metabolism_Homo sapiens_hsa005000.12545612
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12173489
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10057736
141Fat digestion and absorption_Homo sapiens_hsa049750.10030162
142Tight junction_Homo sapiens_hsa045300.09690040
143Vitamin digestion and absorption_Homo sapiens_hsa049770.07962007

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