RRAGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.31661315
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.95186674
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27559218
4synaptic vesicle exocytosis (GO:0016079)4.99265213
5glutamate secretion (GO:0014047)4.81500555
6regulation of synaptic vesicle exocytosis (GO:2000300)4.61265829
7layer formation in cerebral cortex (GO:0021819)4.46872509
8locomotory exploration behavior (GO:0035641)4.43952199
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.33879190
10protein retention in ER lumen (GO:0006621)4.22955891
11proline transport (GO:0015824)4.11535987
12regulation of synaptic vesicle transport (GO:1902803)4.05030015
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.01843379
14negative regulation of microtubule polymerization (GO:0031115)3.94319502
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.85967915
16neurotransmitter secretion (GO:0007269)3.83565345
17vocalization behavior (GO:0071625)3.76379807
18cell migration in hindbrain (GO:0021535)3.72550880
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.64806976
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63757376
21exploration behavior (GO:0035640)3.63025473
22protein localization to synapse (GO:0035418)3.59799179
23sodium ion export (GO:0071436)3.48482257
24regulation of glutamate receptor signaling pathway (GO:1900449)3.47484299
25neuron cell-cell adhesion (GO:0007158)3.45433955
26activation of protein kinase A activity (GO:0034199)3.40685500
27innervation (GO:0060384)3.38310739
28regulation of neuronal synaptic plasticity (GO:0048168)3.33641827
29L-serine transport (GO:0015825)3.33227161
30neuronal action potential propagation (GO:0019227)3.32901975
31response to pheromone (GO:0019236)3.31023969
32dendritic spine morphogenesis (GO:0060997)3.25391836
33cellular potassium ion homeostasis (GO:0030007)3.21986875
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.21754242
35regulation of synapse structural plasticity (GO:0051823)3.19580570
36type B pancreatic cell proliferation (GO:0044342)3.17311527
37positive regulation of synapse maturation (GO:0090129)3.16551718
38regulation of early endosome to late endosome transport (GO:2000641)3.15553839
39neurotransmitter transport (GO:0006836)3.14108708
40protein localization to endosome (GO:0036010)3.13344345
41protein heterotrimerization (GO:0070208)3.10887027
42barbed-end actin filament capping (GO:0051016)3.09973446
43organelle transport along microtubule (GO:0072384)3.09025765
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09001636
45detection of temperature stimulus (GO:0016048)3.07994690
46regulation of clathrin-mediated endocytosis (GO:2000369)3.05518390
47establishment of mitochondrion localization (GO:0051654)3.04078720
48axon extension (GO:0048675)3.01023241
49kidney mesenchyme development (GO:0072074)2.99600541
50neuromuscular process controlling balance (GO:0050885)2.99338239
51neuron recognition (GO:0008038)2.96743449
52vesicle transport along microtubule (GO:0047496)2.96558899
53neuromuscular process controlling posture (GO:0050884)2.96221906
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95659962
55mitochondrion transport along microtubule (GO:0047497)2.95659962
56cerebellar Purkinje cell layer development (GO:0021680)2.93889515
57serine transport (GO:0032329)2.93768004
58extracellular fibril organization (GO:0043206)2.93561673
59metanephric mesenchyme development (GO:0072075)2.91330089
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89922768
61regulation of calcium ion-dependent exocytosis (GO:0017158)2.89142785
62regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.88174167
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87816435
64synaptic transmission, glutamatergic (GO:0035249)2.87704877
65skin morphogenesis (GO:0043589)2.86676422
66cell communication by electrical coupling (GO:0010644)2.85082663
67regulation of vesicle fusion (GO:0031338)2.84636692
68regulation of neurotransmitter levels (GO:0001505)2.82742494
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82333709
70calcium-mediated signaling using intracellular calcium source (GO:0035584)2.80324401
71positive regulation of mitochondrial fission (GO:0090141)2.79907913
72gamma-aminobutyric acid transport (GO:0015812)2.78068231
73membrane repolarization (GO:0086009)2.77551782
74vesicle coating (GO:0006901)2.77252678
75neuron projection extension (GO:1990138)2.76980414
76neuron-neuron synaptic transmission (GO:0007270)2.76598650
77COPI coating of Golgi vesicle (GO:0048205)2.76429158
78Golgi transport vesicle coating (GO:0048200)2.76429158
79mating behavior (GO:0007617)2.75445016
80axon cargo transport (GO:0008088)2.75306688
81glycine transport (GO:0015816)2.73257277
82peptidyl-proline hydroxylation (GO:0019511)2.73042624
83protein maturation by protein folding (GO:0022417)2.73027725
84regulation of synaptic plasticity (GO:0048167)2.71235741
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69625967
86actin filament depolymerization (GO:0030042)2.67895762
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.67295852
88detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.65993001
89detection of temperature stimulus involved in sensory perception (GO:0050961)2.65993001
90dendritic spine organization (GO:0097061)2.65959475
91axonal fasciculation (GO:0007413)2.65244007
92mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.64862943
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64623006
94dendrite morphogenesis (GO:0048813)2.64513912
95synaptic vesicle endocytosis (GO:0048488)2.63841863
96stress fiber assembly (GO:0043149)2.63644471
97positive regulation of membrane potential (GO:0045838)2.60592551
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59709188
99cerebellar Purkinje cell differentiation (GO:0021702)2.59136288
100glutamate receptor signaling pathway (GO:0007215)2.58665707
101membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57783126
102positive regulation of axon extension (GO:0045773)2.56428987
103establishment of vesicle localization (GO:0051650)2.54968946
104synapse organization (GO:0050808)2.54700347
105membrane repolarization during action potential (GO:0086011)2.54039317
106positive regulation of exocytosis (GO:0045921)2.52631775
107long-term synaptic potentiation (GO:0060291)2.51529567
108neuromuscular process (GO:0050905)2.51076894
109fibril organization (GO:0097435)2.48948284
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48256036
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.47397983
112regulation of neurotransmitter secretion (GO:0046928)2.46850599
113behavioral fear response (GO:0001662)2.46173739
114behavioral defense response (GO:0002209)2.46173739
115cerebellum development (GO:0021549)2.46044094
116neurotransmitter-gated ion channel clustering (GO:0072578)2.45910833
117regulation of autophagic vacuole assembly (GO:2000785)2.45694295
118basement membrane organization (GO:0071711)2.45562832
119receptor recycling (GO:0001881)2.45106914
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43785119
121regulation of amyloid precursor protein catabolic process (GO:1902991)2.43674160
122cerebellar granule cell differentiation (GO:0021707)2.43122550
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.42885867
124synaptic vesicle transport (GO:0048489)2.42797612
125establishment of synaptic vesicle localization (GO:0097480)2.42797612
126regulation of protein targeting to membrane (GO:0090313)2.37591733
127protein hydroxylation (GO:0018126)2.37518747
128amino acid import (GO:0043090)2.34227622
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.33924395
130cell adhesion mediated by integrin (GO:0033627)2.29258118
131potassium ion homeostasis (GO:0055075)2.29161170
132cellular copper ion homeostasis (GO:0006878)2.28456613
133virion attachment to host cell (GO:0019062)2.28229127
134adhesion of symbiont to host cell (GO:0044650)2.28229127
135protein insertion into membrane (GO:0051205)2.27073564
1364-hydroxyproline metabolic process (GO:0019471)2.26526207
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25644956
138neuronal ion channel clustering (GO:0045161)2.25381763
139endoplasmic reticulum organization (GO:0007029)2.25070237
140growth hormone secretion (GO:0030252)2.24875686
141positive regulation of vesicle fusion (GO:0031340)2.20963537
142positive regulation of protein targeting to membrane (GO:0090314)2.19232092
143adhesion of symbiont to host (GO:0044406)2.18891240
144developmental cell growth (GO:0048588)2.18870761
145nuclear envelope reassembly (GO:0031468)2.18341204
146mitotic nuclear envelope reassembly (GO:0007084)2.18341204
147protein targeting to plasma membrane (GO:0072661)2.18160847
148postsynaptic membrane organization (GO:0001941)2.18153584
149regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15860643
150negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.14807382
151membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13588326
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.13255303
153membrane budding (GO:0006900)2.12771378
154transferrin transport (GO:0033572)2.12647393
155endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.11893776
156negative regulation of catenin import into nucleus (GO:0035414)2.10894471
157axon extension involved in axon guidance (GO:0048846)2.10679491
158neuron projection extension involved in neuron projection guidance (GO:1902284)2.10679491
159extracellular matrix assembly (GO:0085029)2.09207509
160negative regulation of cell size (GO:0045792)2.08470523
161vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.07648598
162detection of calcium ion (GO:0005513)2.07452765
163pyrimidine nucleobase catabolic process (GO:0006208)2.05763423
164substantia nigra development (GO:0021762)2.04186811
165collagen fibril organization (GO:0030199)2.03176584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64240919
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.02754887
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.93547067
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.09992926
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.07133032
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89955348
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.85534834
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.77912428
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.66617791
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.57178300
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55367466
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52267358
13REST_21632747_ChIP-Seq_MESCs_Mouse2.47441686
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47190244
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47190244
16CLOCK_20551151_ChIP-Seq_293T_Human2.46176228
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.46004060
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40674222
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37141414
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34368968
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31816096
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29809999
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.22110319
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21811538
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21337806
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15817333
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12908059
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11421708
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04077052
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99673108
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.98688295
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97037938
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.94439599
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.93038491
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90050614
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.88565724
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84559858
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82184650
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80260325
40KDM2B_26808549_Chip-Seq_K562_Human1.77573459
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76003615
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.73747113
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73653802
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70464024
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70096409
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63962825
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63449176
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61736717
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.58695942
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57870016
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56051974
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53062322
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52672830
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51519721
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50536449
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47907426
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45628351
58GBX2_23144817_ChIP-Seq_PC3_Human1.44156721
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43384715
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.39659759
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.38908878
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38033964
63RACK7_27058665_Chip-Seq_MCF-7_Human1.37391851
64DROSHA_22980978_ChIP-Seq_HELA_Human1.35154996
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.34667144
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.34056248
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33875169
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31749631
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29619913
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28817616
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28771320
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27946340
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25192796
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25015725
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.23466593
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23330683
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.22862989
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21970562
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21970562
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21970562
81CREB1_26743006_Chip-Seq_LNCaP_Human1.21287370
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20642453
83NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19293996
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19173258
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19089308
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18513279
87* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17447770
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16457894
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16234875
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15326007
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14884898
92LXR_22292898_ChIP-Seq_THP-1_Human1.14284085
93AR_21572438_ChIP-Seq_LNCaP_Human1.14253681
94* TP53_22127205_ChIP-Seq_IMR90_Human1.13226656
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10653282
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10428974
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09945958
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.08773687
99* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06678149
100AR_19668381_ChIP-Seq_PC3_Human1.06587284
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.05028995
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.05028995
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03897942
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03884382
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03469717
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02987642
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00798046
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00267449
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00184387
110CTCF_27219007_Chip-Seq_Bcells_Human0.99065067
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98926219
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98918250
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.98833018
114SMC4_20622854_ChIP-Seq_HELA_Human0.98279481
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97989586
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97615704
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97598595
118KDM2B_26808549_Chip-Seq_DND41_Human0.96019781
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.95663521
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95130799
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93385538
122TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93154632
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92894640
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92236332
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91569327
126ZNF274_21170338_ChIP-Seq_K562_Hela0.90906532
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90615389
128RNF2_27304074_Chip-Seq_NSC_Mouse0.90547078
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90461260
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90412455
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89803752
132ZNF263_19887448_ChIP-Seq_K562_Human0.89706767
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89048326
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87904972
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.87663166
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.86129666
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85798353
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85584200
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84507705
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.82572207
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82187725
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.79530953
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78065026
144EOMES_21245162_ChIP-Seq_HESCs_Human0.77964395
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77065606
146TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.77052711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09651797
2MP0008438_abnormal_cutaneous_collagen4.73894208
3MP0004270_analgesia3.79860608
4MP0003635_abnormal_synaptic_transmissio3.25684205
5MP0003880_abnormal_central_pattern3.11797577
6MP0004858_abnormal_nervous_system2.92565931
7MP0002063_abnormal_learning/memory/cond2.63706989
8MP0002064_seizures2.44527157
9MP0002734_abnormal_mechanical_nocicepti2.30353677
10MP0009745_abnormal_behavioral_response2.27311629
11MP0004272_abnormal_basement_membrane2.26769196
12MP0001968_abnormal_touch/_nociception2.25283263
13MP0003329_amyloid_beta_deposits2.21489136
14MP0003283_abnormal_digestive_organ2.20589996
15MP0003279_aneurysm2.20533472
16MP0003122_maternal_imprinting2.20505133
17MP0002733_abnormal_thermal_nociception2.19643276
18MP0002909_abnormal_adrenal_gland2.18723317
19MP0002653_abnormal_ependyma_morphology2.15790506
20MP0005275_abnormal_skin_tensile2.15590456
21MP0009046_muscle_twitch2.14049268
22MP0002572_abnormal_emotion/affect_behav2.09222727
23MP0001958_emphysema2.04462881
24MP0005257_abnormal_intraocular_pressure2.04289608
25MP0002272_abnormal_nervous_system1.99276822
26MP0005503_abnormal_tendon_morphology1.97090618
27MP0005423_abnormal_somatic_nervous1.95850749
28MP0002735_abnormal_chemical_nociception1.89672160
29MP0001542_abnormal_bone_strength1.87964584
30MP0009780_abnormal_chondrocyte_physiolo1.86863472
31MP0005499_abnormal_olfactory_system1.81556422
32MP0005394_taste/olfaction_phenotype1.81556422
33MP0004811_abnormal_neuron_physiology1.80371375
34MP0010368_abnormal_lymphatic_system1.78917717
35MP0001970_abnormal_pain_threshold1.78643351
36MP0002736_abnormal_nociception_after1.75870701
37MP0002184_abnormal_innervation1.75700520
38MP0000955_abnormal_spinal_cord1.72880114
39MP0006072_abnormal_retinal_apoptosis1.71376113
40MP0008260_abnormal_autophagy1.66753503
41MP0000778_abnormal_nervous_system1.65300866
42MP0006276_abnormal_autonomic_nervous1.64585179
43MP0008961_abnormal_basal_metabolism1.58078585
44MP0000749_muscle_degeneration1.54665747
45MP0004885_abnormal_endolymph1.52691751
46MP0003566_abnormal_cell_adhesion1.51215533
47MP0002067_abnormal_sensory_capabilities1.48622735
48MP0001440_abnormal_grooming_behavior1.48185179
49MP0000750_abnormal_muscle_regeneration1.48112789
50MP0002882_abnormal_neuron_morphology1.47973017
51MP0004233_abnormal_muscle_weight1.47966890
52MP0010234_abnormal_vibrissa_follicle1.46989454
53MP0001486_abnormal_startle_reflex1.45005394
54MP0000013_abnormal_adipose_tissue1.43895029
55MP0002295_abnormal_pulmonary_circulatio1.40659872
56MP0003705_abnormal_hypodermis_morpholog1.40392069
57MP0001348_abnormal_lacrimal_gland1.40349541
58MP0005058_abnormal_lysosome_morphology1.39715130
59MP0001501_abnormal_sleep_pattern1.39320635
60MP0003191_abnormal_cellular_cholesterol1.36927368
61MP0002557_abnormal_social/conspecific_i1.30378999
62MP0002896_abnormal_bone_mineralization1.27811515
63MP0004145_abnormal_muscle_electrophysio1.26985304
64MP0002066_abnormal_motor_capabilities/c1.25254677
65MP0008569_lethality_at_weaning1.25109884
66MP0009384_cardiac_valve_regurgitation1.21563115
67MP0008789_abnormal_olfactory_epithelium1.19910297
68MP0005508_abnormal_skeleton_morphology1.19794363
69MP0000733_abnormal_muscle_development1.17973298
70MP0003879_abnormal_hair_cell1.15481166
71MP0002229_neurodegeneration1.13546384
72MP0005623_abnormal_meninges_morphology1.13300807
73MP0009840_abnormal_foam_cell1.13073859
74MP0005386_behavior/neurological_phenoty1.12967740
75MP0004924_abnormal_behavior1.12967740
76MP0003634_abnormal_glial_cell1.12542847
77MP0002152_abnormal_brain_morphology1.11471144
78MP0003091_abnormal_cell_migration1.11393532
79MP0010386_abnormal_urinary_bladder1.10718642
80MP0004043_abnormal_pH_regulation1.10115268
81MP0001984_abnormal_olfaction1.08757119
82MP0003123_paternal_imprinting1.08690783
83MP0003385_abnormal_body_wall1.07706346
84MP0000751_myopathy1.06557990
85MP0000920_abnormal_myelination1.03384810
86MP0002877_abnormal_melanocyte_morpholog1.02569718
87MP0001502_abnormal_circadian_rhythm1.02100546
88MP0000467_abnormal_esophagus_morphology1.01867146
89MP0005409_darkened_coat_color1.01812457
90MP0005551_abnormal_eye_electrophysiolog1.01507029
91MP0004142_abnormal_muscle_tone0.99782834
92MP0002752_abnormal_somatic_nervous0.98670322
93MP0004087_abnormal_muscle_fiber0.98410479
94MP0000767_abnormal_smooth_muscle0.98005066
95MP0000762_abnormal_tongue_morphology0.97385396
96MP0003633_abnormal_nervous_system0.97049541
97MP0005187_abnormal_penis_morphology0.92451505
98MP0003119_abnormal_digestive_system0.92278998
99MP0001270_distended_abdomen0.90523374
100MP0005253_abnormal_eye_physiology0.89836526
101MP0002751_abnormal_autonomic_nervous0.89688283
102MP0001299_abnormal_eye_distance/0.89381965
103MP0002332_abnormal_exercise_endurance0.89063206
104MP0003075_altered_response_to0.88840426
105MP0003890_abnormal_embryonic-extraembry0.88327025
106MP0003861_abnormal_nervous_system0.87627690
107MP0003221_abnormal_cardiomyocyte_apopto0.87580065
108MP0000747_muscle_weakness0.87294333
109MP0003950_abnormal_plasma_membrane0.86601542
110MP0008874_decreased_physiological_sensi0.85955568
111MP0002234_abnormal_pharynx_morphology0.85723492
112MP0001905_abnormal_dopamine_level0.85661435
113MP0003121_genomic_imprinting0.85629060
114MP0000534_abnormal_ureter_morphology0.85398654
115MP0002060_abnormal_skin_morphology0.84489380
116MP0005165_increased_susceptibility_to0.83820394
117MP0002837_dystrophic_cardiac_calcinosis0.82658713
118MP0010030_abnormal_orbit_morphology0.82483840
119MP0000604_amyloidosis0.82013372
120MP0003787_abnormal_imprinting0.81034021
121MP0002069_abnormal_eating/drinking_beha0.80723901
122MP0002822_catalepsy0.80292828
123MP0003631_nervous_system_phenotype0.80107262
124MP0004510_myositis0.79920076
125MP0001529_abnormal_vocalization0.79853847
126MP0002106_abnormal_muscle_physiology0.79316149
127MP0003172_abnormal_lysosome_physiology0.78509747
128MP0002269_muscular_atrophy0.77436127
129MP0004085_abnormal_heartbeat0.77258999
130MP0005330_cardiomyopathy0.76892174
131MP0002090_abnormal_vision0.76090100
132MP0001879_abnormal_lymphatic_vessel0.75635540
133MP0001188_hyperpigmentation0.75023535
134MP0001849_ear_inflammation0.74068810
135MP0000631_abnormal_neuroendocrine_gland0.73966741
136MP0005248_abnormal_Harderian_gland0.73096446
137MP0003115_abnormal_respiratory_system0.72314033
138MP0003632_abnormal_nervous_system0.72233483
139MP0005369_muscle_phenotype0.71844411
140MP0006054_spinal_hemorrhage0.69672793
141MP0005645_abnormal_hypothalamus_physiol0.67384324
142MP0000003_abnormal_adipose_tissue0.66176625
143MP0005195_abnormal_posterior_eye0.66171904
144MP0001944_abnormal_pancreas_morphology0.65091110
145MP0003942_abnormal_urinary_system0.64758123
146MP0000639_abnormal_adrenal_gland0.60019871
147MP0000759_abnormal_skeletal_muscle0.58514602
148MP0006035_abnormal_mitochondrial_morpho0.58012420

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.14270803
2Myokymia (HP:0002411)5.04315403
3Visual hallucinations (HP:0002367)4.79971552
4Protrusio acetabuli (HP:0003179)4.70426840
5Focal seizures (HP:0007359)3.91790572
6Focal motor seizures (HP:0011153)3.80312668
7Abnormality of the lower motor neuron (HP:0002366)3.79302596
8Atonic seizures (HP:0010819)3.64132642
9Type 1 muscle fiber predominance (HP:0003803)3.37383788
10Supranuclear gaze palsy (HP:0000605)3.35792376
11Vertebral compression fractures (HP:0002953)3.31211434
12Epileptic encephalopathy (HP:0200134)3.23483850
13Absence seizures (HP:0002121)3.23136613
14Dialeptic seizures (HP:0011146)3.09680337
15Ankle contracture (HP:0006466)3.05212639
16Generalized tonic-clonic seizures (HP:0002069)3.04747321
17Action tremor (HP:0002345)3.01886193
18Spinal rigidity (HP:0003306)3.00414811
19Insidious onset (HP:0003587)2.98461194
20Termporal pattern (HP:0011008)2.98461194
21Vascular tortuosity (HP:0004948)2.97159832
22Abnormality of dentin (HP:0010299)2.82587275
23Ankle clonus (HP:0011448)2.81214051
24Depression (HP:0000716)2.81213138
25Amyotrophic lateral sclerosis (HP:0007354)2.78761895
26Increased variability in muscle fiber diameter (HP:0003557)2.78225843
27Cerebral inclusion bodies (HP:0100314)2.70214082
28Atrophic scars (HP:0001075)2.69083186
29Amblyopia (HP:0000646)2.67409271
30Arterial tortuosity (HP:0005116)2.64794525
31Mildly elevated creatine phosphokinase (HP:0008180)2.63577354
32Pheochromocytoma (HP:0002666)2.58381164
33Abnormality of the corticospinal tract (HP:0002492)2.56408908
34Exercise-induced myalgia (HP:0003738)2.56120636
35Follicular hyperkeratosis (HP:0007502)2.53193757
36Aortic dissection (HP:0002647)2.50731556
37Limb-girdle muscle atrophy (HP:0003797)2.50339117
38Abnormality of skeletal muscle fiber size (HP:0012084)2.49874875
39Postural tremor (HP:0002174)2.43459691
40Impaired vibration sensation in the lower limbs (HP:0002166)2.40314720
41Limb-girdle muscle weakness (HP:0003325)2.39685764
42Resting tremor (HP:0002322)2.33334085
43Bladder diverticulum (HP:0000015)2.33218344
44Progressive cerebellar ataxia (HP:0002073)2.32188355
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31835026
46Neoplasm of the heart (HP:0100544)2.31572420
47Apathy (HP:0000741)2.30949914
48Wormian bones (HP:0002645)2.30748809
49Back pain (HP:0003418)2.30539483
50Torticollis (HP:0000473)2.29942369
51Spastic gait (HP:0002064)2.25965017
52Failure to thrive in infancy (HP:0001531)2.24143091
53Hypercortisolism (HP:0001578)2.24072558
54Achilles tendon contracture (HP:0001771)2.24007720
55Febrile seizures (HP:0002373)2.23441506
56Neurofibrillary tangles (HP:0002185)2.22766249
57Rapidly progressive (HP:0003678)2.20592462
58Distal lower limb amyotrophy (HP:0008944)2.19955789
59Hand muscle atrophy (HP:0009130)2.19930896
60Anxiety (HP:0000739)2.19544707
61Hammertoe (HP:0001765)2.19202433
62EEG with generalized epileptiform discharges (HP:0011198)2.18625313
63Upper limb amyotrophy (HP:0009129)2.18024388
64Distal upper limb amyotrophy (HP:0007149)2.18024388
65Distal lower limb muscle weakness (HP:0009053)2.17984759
66Difficulty climbing stairs (HP:0003551)2.17765634
67Hypsarrhythmia (HP:0002521)2.17645461
68Epileptiform EEG discharges (HP:0011182)2.15550661
69Neuroendocrine neoplasm (HP:0100634)2.15504413
70Agitation (HP:0000713)2.13772685
71Urinary urgency (HP:0000012)2.13188472
72Growth hormone excess (HP:0000845)2.12677588
73Generalized hypotonia (HP:0001290)2.12611127
74Shallow orbits (HP:0000586)2.12338227
75Dysdiadochokinesis (HP:0002075)2.12085487
76Slender build (HP:0001533)2.10891658
77Abnormality of the musculature of the pelvis (HP:0001469)2.10030079
78Abnormality of the hip-girdle musculature (HP:0001445)2.10030079
79Fragile skin (HP:0001030)2.09083942
80Hepatoblastoma (HP:0002884)2.08823261
81Neuronal loss in central nervous system (HP:0002529)2.07705721
82Focal dystonia (HP:0004373)2.06801657
83Exercise-induced muscle cramps (HP:0003710)2.05156097
84Soft skin (HP:0000977)2.04121098
85Hypoventilation (HP:0002791)2.04108432
86Abnormality of the Achilles tendon (HP:0005109)2.03705254
87Diminished motivation (HP:0000745)2.02660404
88Increased connective tissue (HP:0009025)2.02610005
89Posterior subcapsular cataract (HP:0007787)2.02604420
90Mutism (HP:0002300)2.02277069
91Hemiparesis (HP:0001269)2.01845667
92Craniofacial dystonia (HP:0012179)2.00995790
93Cholecystitis (HP:0001082)2.00205887
94Abnormal gallbladder physiology (HP:0012438)2.00205887
95Axonal loss (HP:0003447)1.98789079
96Hyperextensible skin (HP:0000974)1.98716574
97Hyperventilation (HP:0002883)1.98388432
98Megalencephaly (HP:0001355)1.98106167
99Papilledema (HP:0001085)1.98071601
100Ankyloglossia (HP:0010296)1.97899894
101Short nail (HP:0001799)1.97505735
102Generalized myoclonic seizures (HP:0002123)1.96336008
103Central scotoma (HP:0000603)1.95588596
104Lower limb amyotrophy (HP:0007210)1.95566964
105Cervical subluxation (HP:0003308)1.94674321
106Myopathic facies (HP:0002058)1.94591015
107Scanning speech (HP:0002168)1.94435848
108Abnormal eating behavior (HP:0100738)1.92935191
109Abnormality of pain sensation (HP:0010832)1.92388219
110Impaired pain sensation (HP:0007328)1.92388219
111Aortic aneurysm (HP:0004942)1.91588135
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.90935985
113Limb dystonia (HP:0002451)1.90490419
114Mitral regurgitation (HP:0001653)1.90449379
115Scapular winging (HP:0003691)1.89847228
116Postural instability (HP:0002172)1.89490987
117Round ear (HP:0100830)1.89411537
118Blue sclerae (HP:0000592)1.88016579
119Status epilepticus (HP:0002133)1.87972034
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87571648
121Urinary bladder sphincter dysfunction (HP:0002839)1.87230955
122Peripheral hypomyelination (HP:0007182)1.87038618
123Asymmetric septal hypertrophy (HP:0001670)1.85775922
124Nemaline bodies (HP:0003798)1.85333128
125Abnormal social behavior (HP:0012433)1.84505173
126Impaired social interactions (HP:0000735)1.84505173
127Peritonitis (HP:0002586)1.84447272
128Drooling (HP:0002307)1.83479794
129Excessive salivation (HP:0003781)1.83479794
130Muscle fiber inclusion bodies (HP:0100299)1.82787278
131Dysmetria (HP:0001310)1.82780691
132Ventricular fibrillation (HP:0001663)1.82366491
133Truncal ataxia (HP:0002078)1.82066730
134Genu recurvatum (HP:0002816)1.81974673
135Long toe (HP:0010511)1.81590987
136Buphthalmos (HP:0000557)1.80713489
137Poor eye contact (HP:0000817)1.80072572
138Nuclear cataract (HP:0100018)1.79427539
139Foot dorsiflexor weakness (HP:0009027)1.79337239
140Myotonia (HP:0002486)1.79046725
141Delusions (HP:0000746)1.78706950
142Cerebral aneurysm (HP:0004944)1.78114728
143Intellectual disability, profound (HP:0002187)1.77326956
144Bradykinesia (HP:0002067)1.76260501
145Mitral stenosis (HP:0001718)1.76256387
146Clonus (HP:0002169)1.76076394
147Elbow flexion contracture (HP:0002987)1.75859845
148Muscle stiffness (HP:0003552)1.75754351
149Lower limb muscle weakness (HP:0007340)1.75341170
150Neoplasm of the peripheral nervous system (HP:0100007)1.74084298
151Obstructive sleep apnea (HP:0002870)1.73175011
152Pelvic girdle muscle weakness (HP:0003749)1.72804698
153Scotoma (HP:0000575)1.72140516
154Abnormality of the calf musculature (HP:0001430)1.71949487
155Abnormal neuron morphology (HP:0012757)1.71038828
156Abnormality of the motor neurons (HP:0002450)1.71038828
157Hyperparathyroidism (HP:0000843)1.70326422
158Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69979615
159Long palpebral fissure (HP:0000637)1.69974523
160Morphological abnormality of the pyramidal tract (HP:0002062)1.69117341
161Myoglobinuria (HP:0002913)1.68876992
162Cortical dysplasia (HP:0002539)1.68751034
163Abnormality of the foot musculature (HP:0001436)1.68651314
164Muscle fiber splitting (HP:0003555)1.68609511
165Dilatation of the ascending aorta (HP:0005111)1.68452222
166Intention tremor (HP:0002080)1.68203209
167Insomnia (HP:0100785)1.66250948
168Hydroureter (HP:0000072)1.65976617
169Atrophy/Degeneration involving motor neurons (HP:0007373)1.65671449
170Shoulder girdle muscle weakness (HP:0003547)1.64446141
171Bilateral microphthalmos (HP:0007633)1.62569795
172Congenital glaucoma (HP:0001087)1.60980055
173Horizontal nystagmus (HP:0000666)1.60764473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.69265704
2TESK14.22688996
3NTRK33.27625237
4KSR23.10144310
5MAP3K42.82036589
6NTRK12.64068592
7LATS22.63197849
8MARK12.62406630
9ARAF2.57225164
10GRK52.54311721
11MINK12.26697653
12PAK62.23246119
13MAP2K42.09660032
14PRKD31.88302970
15PIM21.86156823
16MOS1.69678463
17SCYL21.67574589
18EPHA41.65824754
19MAP2K71.63629769
20NEK11.58676511
21PRPF4B1.58157229
22MAP3K21.57799149
23KSR11.57254665
24TYRO31.55976318
25ERN11.48404414
26TAOK11.47892137
27UHMK11.47584013
28TAOK21.39795141
29PLK21.36597654
30DAPK21.34235326
31MAP3K111.33921689
32EPHB11.30428157
33MYLK1.28199416
34TTN1.27738132
35EPHB21.22626254
36MAP3K121.22543087
37PAK31.21958210
38NTRK21.18757050
39ALK1.17779827
40RET1.15613404
41CDK141.15606408
42CAMKK11.15285365
43CDK51.13591664
44EPHA21.12506724
45PRKD21.10295044
46BCR1.10095360
47CDK191.09184308
48CDK121.08449456
49PHKG21.05402038
50PHKG11.05402038
51CDK151.01296988
52CDK181.01064532
53LIMK11.00788490
54BCKDK1.00152201
55PAK40.99266042
56EPHA30.98015782
57MAP3K10.97973568
58BRAF0.97095905
59GRK60.96687677
60PRKCH0.92888161
61MAP2K10.92858249
62DYRK1B0.90842315
63MAP4K20.88496554
64DDR20.88319734
65CDK11A0.87699800
66STK380.87531478
67TRIB30.87275722
68PDGFRA0.86914343
69PRKCG0.85444292
70RAF10.85039294
71HIPK20.83649153
72MAPK130.82423740
73CSNK1G20.81041906
74MAP3K60.79688179
75DAPK10.78118471
76ABL20.77129195
77MARK20.77063544
78PNCK0.73355213
79MAP3K50.71771367
80DAPK30.68937757
81PTK20.68865367
82FER0.67067417
83CAMK2A0.66538946
84MAP3K130.65881268
85MAP3K30.65370547
86IRAK30.65078369
87SGK4940.65036024
88SGK2230.65036024
89ICK0.64424359
90PAK20.64389293
91DYRK1A0.62932272
92CSNK1G10.62284482
93WNK10.61847903
94DYRK20.60977716
95ADRBK10.58923954
96STK110.53876332
97SIK10.53250910
98NEK90.52752650
99CAMKK20.51289010
100PRKD10.49085639
101CSNK1G30.48927440
102PKN20.47962348
103MAPKAPK30.47685088
104ERBB40.46842554
105SIK20.45977494
106MET0.44831510
107TGFBR20.42600898
108CAMK40.41889771
109MAPK120.41257147
110ROCK10.40468134
111CAMK2B0.40339019
112MAPK100.40048995
113AKT20.39682665
114RPS6KA20.39662248
115CDC42BPA0.38753795
116PAK10.38463786
117LMTK20.38429879
118TESK20.37758882
119MATK0.37758072
120PDPK10.37755060
121ROCK20.37720750
122CASK0.37351699
123RPS6KA30.37242562
124RIPK10.37072471
125CSNK1E0.36276207
126DYRK30.35764631
127PRKCI0.35635757
128PRKCZ0.35395331
129ERBB30.34295973
130CSNK1A1L0.33699050
131CAMK2G0.31197852
132PTK2B0.29523886
133MAP3K70.29109203
134WNK40.27089142
135CAMK2D0.27034227

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.53737367
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.71809917
3GABAergic synapse_Homo sapiens_hsa047272.38597199
4Nicotine addiction_Homo sapiens_hsa050332.32315631
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.27510170
6Long-term potentiation_Homo sapiens_hsa047202.25899508
7Olfactory transduction_Homo sapiens_hsa047402.11207944
8Dopaminergic synapse_Homo sapiens_hsa047282.08444798
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01174332
10Insulin secretion_Homo sapiens_hsa049112.00493133
11Circadian entrainment_Homo sapiens_hsa047131.99467299
12Glutamatergic synapse_Homo sapiens_hsa047241.94301121
13Amphetamine addiction_Homo sapiens_hsa050311.91928601
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71316348
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.64448052
16Morphine addiction_Homo sapiens_hsa050321.62973709
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61918067
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61334645
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59936848
20Cholinergic synapse_Homo sapiens_hsa047251.59889621
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57635086
22Collecting duct acid secretion_Homo sapiens_hsa049661.55559328
23Phenylalanine metabolism_Homo sapiens_hsa003601.53704762
24Cocaine addiction_Homo sapiens_hsa050301.50850433
25GnRH signaling pathway_Homo sapiens_hsa049121.48489156
26Gastric acid secretion_Homo sapiens_hsa049711.48467841
27Fatty acid elongation_Homo sapiens_hsa000621.47365092
28Vibrio cholerae infection_Homo sapiens_hsa051101.46254552
29Serotonergic synapse_Homo sapiens_hsa047261.46191813
30Long-term depression_Homo sapiens_hsa047301.46099372
31Taste transduction_Homo sapiens_hsa047421.45900448
32Salivary secretion_Homo sapiens_hsa049701.45529505
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45403620
34Gap junction_Homo sapiens_hsa045401.45102886
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39362590
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36896485
37Oxytocin signaling pathway_Homo sapiens_hsa049211.32345392
38Nitrogen metabolism_Homo sapiens_hsa009101.30967540
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27345753
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25838002
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19668162
42Glioma_Homo sapiens_hsa052141.19103487
43Renin secretion_Homo sapiens_hsa049241.18866394
44Estrogen signaling pathway_Homo sapiens_hsa049151.18069257
45Dorso-ventral axis formation_Homo sapiens_hsa043201.16879323
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13740455
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13089213
48Arginine and proline metabolism_Homo sapiens_hsa003301.10554080
49Carbon metabolism_Homo sapiens_hsa012001.09406410
50Biosynthesis of amino acids_Homo sapiens_hsa012301.07157524
51Oocyte meiosis_Homo sapiens_hsa041141.04359099
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03910147
53Axon guidance_Homo sapiens_hsa043601.01785250
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01124171
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00804510
56Type II diabetes mellitus_Homo sapiens_hsa049300.99800827
57Focal adhesion_Homo sapiens_hsa045100.99533086
58* mTOR signaling pathway_Homo sapiens_hsa041500.98215454
59Cardiac muscle contraction_Homo sapiens_hsa042600.96515543
60AMPK signaling pathway_Homo sapiens_hsa041520.95909632
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95479604
62Pancreatic secretion_Homo sapiens_hsa049720.93408690
63ECM-receptor interaction_Homo sapiens_hsa045120.93029272
64ErbB signaling pathway_Homo sapiens_hsa040120.92245621
65Pentose phosphate pathway_Homo sapiens_hsa000300.91665640
66cAMP signaling pathway_Homo sapiens_hsa040240.90899232
67Melanogenesis_Homo sapiens_hsa049160.90356231
68Calcium signaling pathway_Homo sapiens_hsa040200.87992039
69Sulfur relay system_Homo sapiens_hsa041220.87187754
70Prion diseases_Homo sapiens_hsa050200.86874361
71Renal cell carcinoma_Homo sapiens_hsa052110.85555440
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85273588
73Shigellosis_Homo sapiens_hsa051310.84732262
74Fructose and mannose metabolism_Homo sapiens_hsa000510.83922634
75beta-Alanine metabolism_Homo sapiens_hsa004100.83003728
76Lysosome_Homo sapiens_hsa041420.81607074
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.80540286
78VEGF signaling pathway_Homo sapiens_hsa043700.80455015
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.80060999
80Bladder cancer_Homo sapiens_hsa052190.79823590
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79730625
82Phototransduction_Homo sapiens_hsa047440.76581206
83Salmonella infection_Homo sapiens_hsa051320.76195595
84Amoebiasis_Homo sapiens_hsa051460.73669599
85Glucagon signaling pathway_Homo sapiens_hsa049220.73496855
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.72243391
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72198493
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72148731
89Colorectal cancer_Homo sapiens_hsa052100.71993680
90Thyroid hormone synthesis_Homo sapiens_hsa049180.71337289
91Endometrial cancer_Homo sapiens_hsa052130.70624651
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69772585
93Phagosome_Homo sapiens_hsa041450.67631791
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67088200
95Proteoglycans in cancer_Homo sapiens_hsa052050.66712807
96Insulin signaling pathway_Homo sapiens_hsa049100.66508853
97Protein digestion and absorption_Homo sapiens_hsa049740.65665328
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.65052412
99Endocytosis_Homo sapiens_hsa041440.64951137
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64653155
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.64205535
102Circadian rhythm_Homo sapiens_hsa047100.63169452
103MAPK signaling pathway_Homo sapiens_hsa040100.63038901
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63006454
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62781064
106Pyruvate metabolism_Homo sapiens_hsa006200.62764079
107Choline metabolism in cancer_Homo sapiens_hsa052310.61961612
108Dilated cardiomyopathy_Homo sapiens_hsa054140.61211814
109Fatty acid metabolism_Homo sapiens_hsa012120.60638378
110Galactose metabolism_Homo sapiens_hsa000520.60200901
111Ras signaling pathway_Homo sapiens_hsa040140.60042357
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59730754
113Arginine biosynthesis_Homo sapiens_hsa002200.57332944
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56475793
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55401101
116Bile secretion_Homo sapiens_hsa049760.55354882
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54561327
118Hippo signaling pathway_Homo sapiens_hsa043900.53880342
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53295325
120Non-small cell lung cancer_Homo sapiens_hsa052230.53142107
121Thyroid cancer_Homo sapiens_hsa052160.52013387
122Tyrosine metabolism_Homo sapiens_hsa003500.51176715
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50782411
124Rap1 signaling pathway_Homo sapiens_hsa040150.50324292
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50037426
126Alzheimers disease_Homo sapiens_hsa050100.49601499
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48901113
128Other glycan degradation_Homo sapiens_hsa005110.47929337
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47551812
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47541316
131Butanoate metabolism_Homo sapiens_hsa006500.47282349
132Hedgehog signaling pathway_Homo sapiens_hsa043400.46977329
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46586235
134Ovarian steroidogenesis_Homo sapiens_hsa049130.46381283
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.45316527
136Wnt signaling pathway_Homo sapiens_hsa043100.45036907
137Type I diabetes mellitus_Homo sapiens_hsa049400.44585470
138Tight junction_Homo sapiens_hsa045300.42028848
139Pancreatic cancer_Homo sapiens_hsa052120.39756905
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39656284

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