RRAGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.10050802
2pyrimidine nucleobase catabolic process (GO:0006208)5.96303431
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62282625
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55261177
5proline transport (GO:0015824)5.42009393
6locomotory exploration behavior (GO:0035641)5.38164230
7glutamate secretion (GO:0014047)5.04359535
8presynaptic membrane assembly (GO:0097105)4.88014779
9nucleobase catabolic process (GO:0046113)4.84815441
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.73991205
11synaptic vesicle exocytosis (GO:0016079)4.64667122
12positive regulation of mitochondrial fission (GO:0090141)4.62436308
13regulation of synaptic vesicle exocytosis (GO:2000300)4.52142716
14vocalization behavior (GO:0071625)4.47853768
15layer formation in cerebral cortex (GO:0021819)4.33626566
16neurotransmitter secretion (GO:0007269)4.33418125
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31630069
18presynaptic membrane organization (GO:0097090)4.26272281
19polyketide metabolic process (GO:0030638)4.21697197
20doxorubicin metabolic process (GO:0044598)4.21697197
21daunorubicin metabolic process (GO:0044597)4.21697197
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.20417794
23postsynaptic membrane organization (GO:0001941)4.11441665
24regulation of glutamate receptor signaling pathway (GO:1900449)4.09468553
25exploration behavior (GO:0035640)4.03235405
26regulation of synaptic vesicle transport (GO:1902803)3.99189761
27protein localization to synapse (GO:0035418)3.90981509
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85765886
29nonmotile primary cilium assembly (GO:0035058)3.83602749
30regulation of neuronal synaptic plasticity (GO:0048168)3.83401606
31neuron cell-cell adhesion (GO:0007158)3.80154322
32gamma-aminobutyric acid transport (GO:0015812)3.79758221
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.76883252
34synaptic transmission, glutamatergic (GO:0035249)3.71274494
35neurotransmitter transport (GO:0006836)3.68250553
36regulation of feeding behavior (GO:0060259)3.67308754
37protein localization to cilium (GO:0061512)3.62908561
38neuronal action potential propagation (GO:0019227)3.61926836
39dendritic spine morphogenesis (GO:0060997)3.57769810
40negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.51906872
41response to dietary excess (GO:0002021)3.48686486
42maintenance of protein location in nucleus (GO:0051457)3.45504533
43regulation of synapse structural plasticity (GO:0051823)3.43667526
44neuron-neuron synaptic transmission (GO:0007270)3.43480629
45cellular potassium ion homeostasis (GO:0030007)3.43095900
46sodium ion export (GO:0071436)3.40902903
47glycine transport (GO:0015816)3.38219265
48positive regulation of synapse maturation (GO:0090129)3.35486599
49long-term memory (GO:0007616)3.33909593
50neuromuscular process controlling posture (GO:0050884)3.30705324
51activation of protein kinase A activity (GO:0034199)3.30137605
52histone H4-K5 acetylation (GO:0043981)3.29844479
53histone H4-K8 acetylation (GO:0043982)3.29844479
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26177846
55neuromuscular process controlling balance (GO:0050885)3.26020621
56regulation of neurotransmitter levels (GO:0001505)3.24021640
57detection of calcium ion (GO:0005513)3.21906628
58glutamate receptor signaling pathway (GO:0007215)3.21539070
59establishment of mitochondrion localization (GO:0051654)3.20913702
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18553301
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17953216
62synapse assembly (GO:0007416)3.16288441
63central nervous system projection neuron axonogenesis (GO:0021952)3.13469076
64auditory behavior (GO:0031223)3.12291401
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11447150
66transmission of nerve impulse (GO:0019226)3.10968978
67calcium-mediated signaling using intracellular calcium source (GO:0035584)3.10494955
68histone H4-K12 acetylation (GO:0043983)3.09990027
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09724905
70vesicle transport along microtubule (GO:0047496)3.08516297
71behavioral defense response (GO:0002209)3.06994199
72behavioral fear response (GO:0001662)3.06994199
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06873773
74mechanosensory behavior (GO:0007638)3.06420723
75glycosphingolipid biosynthetic process (GO:0006688)3.06352831
76positive regulation of synapse assembly (GO:0051965)3.05079678
77regulation of cilium movement (GO:0003352)3.04808187
78synaptic vesicle endocytosis (GO:0048488)3.04775980
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02506097
80startle response (GO:0001964)3.02033769
81cerebellar Purkinje cell differentiation (GO:0021702)3.01874727
82positive regulation of membrane potential (GO:0045838)3.01157561
83cerebellar granule cell differentiation (GO:0021707)2.99567882
84neurotransmitter-gated ion channel clustering (GO:0072578)2.98949249
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98692953
86regulation of mitochondrial fission (GO:0090140)2.98237670
87inositol phosphate catabolic process (GO:0071545)2.98154995
88pre-miRNA processing (GO:0031054)2.96115859
89cell migration in hindbrain (GO:0021535)2.95603261
90regulation of synaptic plasticity (GO:0048167)2.94463022
91brain morphogenesis (GO:0048854)2.93914655
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91355748
93regulation of dendritic spine morphogenesis (GO:0061001)2.90696847
94organelle transport along microtubule (GO:0072384)2.89589809
95regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88660865
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88580632
97retinal ganglion cell axon guidance (GO:0031290)2.88507777
98neuron recognition (GO:0008038)2.87934585
99cell communication by electrical coupling (GO:0010644)2.85371870
100response to auditory stimulus (GO:0010996)2.84724956
101fear response (GO:0042596)2.84573709
102cilium morphogenesis (GO:0060271)2.83060533
103regulation of response to osmotic stress (GO:0047484)2.82467331
104somite rostral/caudal axis specification (GO:0032525)2.80244700
105regulation of microtubule-based movement (GO:0060632)2.79812700
106regulation of postsynaptic membrane potential (GO:0060078)2.78976424
107neuronal ion channel clustering (GO:0045161)2.78953696
108piRNA metabolic process (GO:0034587)2.78674132
109dendrite morphogenesis (GO:0048813)2.77932488
110regulation of vesicle fusion (GO:0031338)2.77291898
111long-term synaptic potentiation (GO:0060291)2.77203100
112negative regulation of telomerase activity (GO:0051974)2.76613565
113central nervous system neuron axonogenesis (GO:0021955)2.76085248
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75983857
115regulation of neurotransmitter secretion (GO:0046928)2.75863915
116intraciliary transport (GO:0042073)2.75249125
117negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.74666900
118detection of temperature stimulus (GO:0016048)2.74510610
119cellular response to leptin stimulus (GO:0044320)2.73954304
120peroxisome fission (GO:0016559)2.73238295
121cerebral cortex radially oriented cell migration (GO:0021799)2.71325757
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.70453572
123innervation (GO:0060384)2.70084730
124cerebellar Purkinje cell layer development (GO:0021680)2.70054685
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.69053113
126neuronal action potential (GO:0019228)2.68343009
127neurofilament cytoskeleton organization (GO:0060052)2.67393702
128striatum development (GO:0021756)2.67341493
129phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67173812
130inositol phosphate dephosphorylation (GO:0046855)2.67173812
131histone H4-K16 acetylation (GO:0043984)2.67051588
132neuromuscular process (GO:0050905)2.66318894
133prepulse inhibition (GO:0060134)2.66258155
134establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66221084
135mitochondrion transport along microtubule (GO:0047497)2.66221084
136positive regulation of glycolytic process (GO:0045821)2.64935770
137axonal fasciculation (GO:0007413)2.64624000
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63401374
139righting reflex (GO:0060013)2.63383863
140positive regulation of amino acid transport (GO:0051957)2.62928091
141regulation of respiratory system process (GO:0044065)2.61969966
142synapsis (GO:0007129)2.60752151
143neural tube formation (GO:0001841)2.59040554
144anterograde axon cargo transport (GO:0008089)2.56327234
145platelet dense granule organization (GO:0060155)2.54967820
146short-term memory (GO:0007614)2.54758305
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53932511
148cullin deneddylation (GO:0010388)2.53673573
149behavioral response to nicotine (GO:0035095)2.53296612
150serotonin metabolic process (GO:0042428)2.53273141
151hippocampus development (GO:0021766)2.51316769
152epithelial cilium movement (GO:0003351)2.49505796
153regulation of dendritic spine development (GO:0060998)2.48551073
154anterograde synaptic vesicle transport (GO:0048490)2.47576935
155protein polyglutamylation (GO:0018095)2.46580506
156regulation of synapse assembly (GO:0051963)2.46435811
157negative regulation of dendrite development (GO:2000171)2.45039165
158DNA integration (GO:0015074)2.44090121
159histone H2A acetylation (GO:0043968)2.43950056
160calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43627848
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.42125121
162ubiquinone metabolic process (GO:0006743)2.41665090
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.40895290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64356312
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38415840
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38415840
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38415840
5ZFP57_27257070_Chip-Seq_ESCs_Mouse3.18674676
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.97099190
7ZNF274_21170338_ChIP-Seq_K562_Hela2.96756194
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.88000921
9REST_21632747_ChIP-Seq_MESCs_Mouse2.79987636
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74557997
11TAF15_26573619_Chip-Seq_HEK293_Human2.62813420
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60805034
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56540716
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54081469
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50527020
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.49245942
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47913953
18FUS_26573619_Chip-Seq_HEK293_Human2.34450443
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32316089
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29918404
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29918404
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29762465
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29002716
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28487403
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28047167
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.14970926
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13662577
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12749231
29P300_19829295_ChIP-Seq_ESCs_Human2.08165804
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06917100
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03245006
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02799368
33JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00512637
34EWS_26573619_Chip-Seq_HEK293_Human1.97725848
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97333354
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96773236
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96416634
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.93208240
39VDR_22108803_ChIP-Seq_LS180_Human1.92749889
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.92615243
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91724769
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91645980
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.91057576
44GBX2_23144817_ChIP-Seq_PC3_Human1.89902745
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.89056886
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88327256
47DROSHA_22980978_ChIP-Seq_HELA_Human1.87940998
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86997569
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.85498433
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84602412
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.83684234
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83482918
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79886411
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.77731214
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77484170
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73869692
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.72056818
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70080627
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68232099
60KDM2B_26808549_Chip-Seq_K562_Human1.66761259
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63644333
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61259282
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.58984779
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56277726
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55436423
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54467606
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53540677
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53286634
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.52961437
70AR_25329375_ChIP-Seq_VCAP_Human1.51003360
71ER_23166858_ChIP-Seq_MCF-7_Human1.50747185
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50353544
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.49861567
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48961946
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.44788330
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42231180
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.41891924
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41357249
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40922366
80CBP_20019798_ChIP-Seq_JUKART_Human1.39122722
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39122722
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37949809
83RNF2_27304074_Chip-Seq_NSC_Mouse1.37838881
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37737267
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37058542
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36558423
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.35921259
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35011391
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33942004
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33768713
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.33711056
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32808464
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31015759
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30077942
95IGF1R_20145208_ChIP-Seq_DFB_Human1.28951409
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.28738860
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.28432939
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28300991
99BCAT_22108803_ChIP-Seq_LS180_Human1.27101307
100E2F1_17053090_ChIP-ChIP_MCF-7_Human1.27099410
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.27092188
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26083708
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25331596
104RUNX2_22187159_ChIP-Seq_PCA_Human1.24504538
105TCF4_23295773_ChIP-Seq_U87_Human1.24034859
106TP53_22573176_ChIP-Seq_HFKS_Human1.23800087
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.22557438
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22508639
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22508639
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21390884
111AR_21572438_ChIP-Seq_LNCaP_Human1.21135663
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21037536
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20740360
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20292641
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20256385
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19240774
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18712145
118* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18503807
119* AR_19668381_ChIP-Seq_PC3_Human1.18370480
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17605195
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17213181
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17174200
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15930502
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14281540
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12591065
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.12383269
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12192597
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11674844
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10845964
130TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08930372
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08438073
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08039324
133P53_22387025_ChIP-Seq_ESCs_Mouse1.07996646
134SMC4_20622854_ChIP-Seq_HELA_Human1.07726894
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.07621133
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07180946
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07179307
138HTT_18923047_ChIP-ChIP_STHdh_Human1.07023108
139CMYC_18555785_Chip-Seq_ESCs_Mouse1.03448165
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.01993859
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01793267
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01720990
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01525649
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01167764
145SMAD4_21799915_ChIP-Seq_A2780_Human1.01112591
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01037701
147STAT3_23295773_ChIP-Seq_U87_Human1.00938284
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00708337
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00300399
150SOX2_19829295_ChIP-Seq_ESCs_Human0.99917051
151NANOG_19829295_ChIP-Seq_ESCs_Human0.99917051
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99821845
153NANOG_16518401_ChIP-PET_MESCs_Mouse0.99786417
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.99456188
155JUN_21703547_ChIP-Seq_K562_Human0.98914870
156TCF4_22108803_ChIP-Seq_LS180_Human0.98743221
157TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98531176
158* ELK1_19687146_ChIP-ChIP_HELA_Human0.98436841
159NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98013592
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95954024
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.95948070
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95934625
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95473997
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.95077333
165GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94965323
166ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94063218
167NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93248171
168CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92540859
169NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91285182
170DPY_21335234_ChIP-Seq_ESCs_Mouse0.90530176
171BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89979480
172MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89937054
173OCT4_19829295_ChIP-Seq_ESCs_Human0.88586077
174GATA1_26923725_Chip-Seq_HPCs_Mouse0.88113082
175P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86843589
176TP53_20018659_ChIP-ChIP_R1E_Mouse0.86777851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.54848677
2MP0003880_abnormal_central_pattern3.65978741
3MP0003635_abnormal_synaptic_transmissio3.55371316
4MP0004270_analgesia3.51588242
5MP0004858_abnormal_nervous_system3.04297037
6MP0003122_maternal_imprinting2.98536927
7MP0009046_muscle_twitch2.92485798
8MP0002063_abnormal_learning/memory/cond2.85897498
9MP0008877_abnormal_DNA_methylation2.82888520
10MP0002064_seizures2.74711605
11MP0009745_abnormal_behavioral_response2.71985977
12MP0002102_abnormal_ear_morphology2.61090287
13MP0002572_abnormal_emotion/affect_behav2.54319310
14MP0005423_abnormal_somatic_nervous2.40817529
15MP0001486_abnormal_startle_reflex2.39773187
16MP0002734_abnormal_mechanical_nocicepti2.36073551
17MP0003787_abnormal_imprinting2.29444606
18MP0005499_abnormal_olfactory_system2.26683442
19MP0005394_taste/olfaction_phenotype2.26683442
20MP0002272_abnormal_nervous_system2.23166276
21MP0002909_abnormal_adrenal_gland2.22260027
22MP0006292_abnormal_olfactory_placode2.12690202
23MP0001968_abnormal_touch/_nociception2.02171276
24MP0002733_abnormal_thermal_nociception1.97644247
25MP0003283_abnormal_digestive_organ1.97544878
26MP0001501_abnormal_sleep_pattern1.91306110
27MP0002822_catalepsy1.89828224
28MP0003121_genomic_imprinting1.89683109
29MP0002638_abnormal_pupillary_reflex1.81744233
30MP0008961_abnormal_basal_metabolism1.79208938
31MP0003890_abnormal_embryonic-extraembry1.78287848
32MP0003123_paternal_imprinting1.76497775
33MP0000955_abnormal_spinal_cord1.75374741
34MP0001970_abnormal_pain_threshold1.73656692
35MP0001440_abnormal_grooming_behavior1.70890539
36MP0004811_abnormal_neuron_physiology1.65748396
37MP0002184_abnormal_innervation1.65228036
38MP0001188_hyperpigmentation1.64909362
39MP0000778_abnormal_nervous_system1.63461482
40MP0004885_abnormal_endolymph1.57696731
41MP0005084_abnormal_gallbladder_morpholo1.55379987
42MP0002067_abnormal_sensory_capabilities1.53792996
43MP0002557_abnormal_social/conspecific_i1.49534446
44MP0002653_abnormal_ependyma_morphology1.49271841
45MP0008569_lethality_at_weaning1.48154261
46MP0004264_abnormal_extraembryonic_tissu1.48131189
47MP0009780_abnormal_chondrocyte_physiolo1.46463921
48MP0004142_abnormal_muscle_tone1.43223847
49MP0005367_renal/urinary_system_phenotyp1.42818852
50MP0000516_abnormal_urinary_system1.42818852
51MP0000569_abnormal_digit_pigmentation1.39582380
52MP0008995_early_reproductive_senescence1.39406012
53MP0005386_behavior/neurological_phenoty1.36941010
54MP0004924_abnormal_behavior1.36941010
55MP0002735_abnormal_chemical_nociception1.36446550
56MP0002882_abnormal_neuron_morphology1.36396918
57MP0004043_abnormal_pH_regulation1.30261976
58MP0002254_reproductive_system_inflammat1.30113207
59MP0003329_amyloid_beta_deposits1.25988671
60MP0002736_abnormal_nociception_after1.25410607
61MP0002066_abnormal_motor_capabilities/c1.24280045
62MP0003183_abnormal_peptide_metabolism1.23759283
63MP0002837_dystrophic_cardiac_calcinosis1.23279253
64MP0001502_abnormal_circadian_rhythm1.19464515
65MP0002332_abnormal_exercise_endurance1.18099128
66MP0005171_absent_coat_pigmentation1.14022186
67MP0005646_abnormal_pituitary_gland1.13256230
68MP0002234_abnormal_pharynx_morphology1.12356563
69MP0005187_abnormal_penis_morphology1.12037327
70MP0002152_abnormal_brain_morphology1.10320670
71MP0003633_abnormal_nervous_system1.09588838
72MP0003011_delayed_dark_adaptation1.07504166
73MP0008058_abnormal_DNA_repair1.05942092
74MP0000372_irregular_coat_pigmentation1.03680593
75MP0000631_abnormal_neuroendocrine_gland1.03661117
76MP0003137_abnormal_impulse_conducting1.01891960
77MP0008872_abnormal_physiological_respon1.01205637
78MP0001348_abnormal_lacrimal_gland1.00898211
79MP0005645_abnormal_hypothalamus_physiol1.00397525
80MP0002229_neurodegeneration0.99706359
81MP0006276_abnormal_autonomic_nervous0.98777023
82MP0006035_abnormal_mitochondrial_morpho0.98737001
83MP0000678_abnormal_parathyroid_gland0.96798549
84MP0003938_abnormal_ear_development0.96050483
85MP0010386_abnormal_urinary_bladder0.95519640
86MP0003172_abnormal_lysosome_physiology0.95309112
87MP0009697_abnormal_copulation0.94086635
88MP0003634_abnormal_glial_cell0.93926743
89MP0003195_calcinosis0.90453043
90MP0003632_abnormal_nervous_system0.90223959
91MP0002752_abnormal_somatic_nervous0.89276603
92MP0003861_abnormal_nervous_system0.88604195
93MP0003631_nervous_system_phenotype0.88597588
94MP0001986_abnormal_taste_sensitivity0.87886410
95MP0001984_abnormal_olfaction0.87817373
96MP0000427_abnormal_hair_cycle0.87649173
97MP0003119_abnormal_digestive_system0.86836080
98MP0003879_abnormal_hair_cell0.86558592
99MP0001905_abnormal_dopamine_level0.86253367
100MP0004145_abnormal_muscle_electrophysio0.83479048
101MP0005623_abnormal_meninges_morphology0.83128624
102MP0004133_heterotaxia0.81967381
103MP0003698_abnormal_male_reproductive0.81586830
104MP0004085_abnormal_heartbeat0.79920283
105MP0005075_abnormal_melanosome_morpholog0.79776341
106MP0002090_abnormal_vision0.79508101
107MP0002069_abnormal_eating/drinking_beha0.76889628
108MP0004147_increased_porphyrin_level0.76636267
109MP0000026_abnormal_inner_ear0.76035705
110MP0006072_abnormal_retinal_apoptosis0.75997624
111MP0002928_abnormal_bile_duct0.74753093
112MP0000647_abnormal_sebaceous_gland0.72835232
113MP0001963_abnormal_hearing_physiology0.72071275
114MP0002751_abnormal_autonomic_nervous0.72056299
115MP0005253_abnormal_eye_physiology0.71466863
116MP0003690_abnormal_glial_cell0.70389218
117MP0005195_abnormal_posterior_eye0.69747541
118MP0000013_abnormal_adipose_tissue0.69415583
119MP0005551_abnormal_eye_electrophysiolog0.68798220
120MP0001529_abnormal_vocalization0.68361558
121MP0004215_abnormal_myocardial_fiber0.67553860
122MP0005535_abnormal_body_temperature0.67457103
123MP0001929_abnormal_gametogenesis0.67133486
124MP0008874_decreased_physiological_sensi0.65993991
125MP0008770_decreased_survivor_rate0.64239645
126MP0008789_abnormal_olfactory_epithelium0.63036609
127MP0002081_perinatal_lethality0.62936509
128MP0010234_abnormal_vibrissa_follicle0.62444659
129MP0001943_abnormal_respiration0.60635099
130MP0000920_abnormal_myelination0.59194988
131MP0010769_abnormal_survival0.57778290

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.25999472
2Focal motor seizures (HP:0011153)4.59824097
3Myokymia (HP:0002411)4.54225355
4Bilateral microphthalmos (HP:0007633)4.42318764
5Focal seizures (HP:0007359)4.22610383
6Visual hallucinations (HP:0002367)4.01209955
7Gait imbalance (HP:0002141)4.00971090
8Polyphagia (HP:0002591)4.00121544
9Epileptic encephalopathy (HP:0200134)3.82887748
10Hepatoblastoma (HP:0002884)3.82564308
11Amyotrophic lateral sclerosis (HP:0007354)3.82515963
12Medial flaring of the eyebrow (HP:0010747)3.81432518
13Limb dystonia (HP:0002451)3.74037370
14Febrile seizures (HP:0002373)3.70144404
15Congenital primary aphakia (HP:0007707)3.64749383
16Hypoglycemic seizures (HP:0002173)3.60728627
17Nephrogenic diabetes insipidus (HP:0009806)3.57557465
18Atonic seizures (HP:0010819)3.54440675
19Dialeptic seizures (HP:0011146)3.18477476
20Ependymoma (HP:0002888)3.17327843
21Hypoglycemic coma (HP:0001325)3.16049303
22Hypothermia (HP:0002045)3.15880939
23Hypochromic microcytic anemia (HP:0004840)3.08855500
24Hemiparesis (HP:0001269)3.05624214
25Hyperventilation (HP:0002883)3.02513127
26Astrocytoma (HP:0009592)3.00364809
27Abnormality of the astrocytes (HP:0100707)3.00364809
28Absence seizures (HP:0002121)3.00198968
29Generalized tonic-clonic seizures (HP:0002069)2.99631423
30Genital tract atresia (HP:0001827)2.98908620
31Supranuclear gaze palsy (HP:0000605)2.98641123
32Hypsarrhythmia (HP:0002521)2.89186559
33Amblyopia (HP:0000646)2.86102421
34Abnormality of midbrain morphology (HP:0002418)2.84467984
35Molar tooth sign on MRI (HP:0002419)2.84467984
36Action tremor (HP:0002345)2.84463050
37EEG with generalized epileptiform discharges (HP:0011198)2.82996186
38Neoplasm of the heart (HP:0100544)2.81950059
39Abnormality of the corticospinal tract (HP:0002492)2.80788205
40Vaginal atresia (HP:0000148)2.79778059
41Epileptiform EEG discharges (HP:0011182)2.78723155
42Pancreatic fibrosis (HP:0100732)2.78617007
43Ketoacidosis (HP:0001993)2.76314215
44Progressive cerebellar ataxia (HP:0002073)2.74373585
45Resting tremor (HP:0002322)2.73779476
46Horizontal nystagmus (HP:0000666)2.70640462
47Ankle clonus (HP:0011448)2.70258313
483-Methylglutaconic aciduria (HP:0003535)2.68553631
49Nephronophthisis (HP:0000090)2.65639877
50Depression (HP:0000716)2.65070460
51Tetraplegia (HP:0002445)2.64583947
52Papilledema (HP:0001085)2.63801017
53True hermaphroditism (HP:0010459)2.60616453
54Pancreatic cysts (HP:0001737)2.58622471
55Rib fusion (HP:0000902)2.57610812
56Generalized hypotonia (HP:0001290)2.54452478
57Tubulointerstitial nephritis (HP:0001970)2.47182221
58Drooling (HP:0002307)2.44836239
59Excessive salivation (HP:0003781)2.44836239
60Dysdiadochokinesis (HP:0002075)2.44328001
61Abnormality of the labia minora (HP:0012880)2.43965167
62Lissencephaly (HP:0001339)2.38484220
63Poor coordination (HP:0002370)2.36860178
64Neoplasm of striated muscle (HP:0009728)2.36773955
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.36661454
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.36661454
67Specific learning disability (HP:0001328)2.35780738
68Progressive inability to walk (HP:0002505)2.34136284
69Muscular hypotonia of the trunk (HP:0008936)2.33993329
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24966091
71Abnormality of the renal medulla (HP:0100957)2.24557955
72Status epilepticus (HP:0002133)2.24085220
73Inability to walk (HP:0002540)2.20641281
74Pachygyria (HP:0001302)2.20258626
75Intention tremor (HP:0002080)2.19407445
76Ankyloglossia (HP:0010296)2.18546473
77Glioma (HP:0009733)2.18354340
78Macroorchidism (HP:0000053)2.17801810
79Impaired vibration sensation in the lower limbs (HP:0002166)2.17652192
80Postural instability (HP:0002172)2.14799743
81Spastic gait (HP:0002064)2.14499252
82Renal duplication (HP:0000075)2.12698734
83Decreased testicular size (HP:0008734)2.12585943
84Mutism (HP:0002300)2.12419035
85Poor eye contact (HP:0000817)2.11997187
86Hyperinsulinemic hypoglycemia (HP:0000825)2.11960807
87Abnormality of ocular smooth pursuit (HP:0000617)2.10926948
88Esotropia (HP:0000565)2.10476097
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10417679
90Progressive macrocephaly (HP:0004481)2.09704520
91Dysmetria (HP:0001310)2.09568819
92Abnormality of the metopic suture (HP:0005556)2.07560915
93Spastic tetraplegia (HP:0002510)2.07322049
94Symptomatic seizures (HP:0011145)2.06807038
95Abnormality of the salivary glands (HP:0010286)2.06281297
96Bifid tongue (HP:0010297)2.06230310
97Bradykinesia (HP:0002067)2.05605134
98Acute necrotizing encephalopathy (HP:0006965)2.05097200
99Hand muscle atrophy (HP:0009130)2.05068980
100Failure to thrive in infancy (HP:0001531)2.04192660
101Neuronal loss in central nervous system (HP:0002529)2.04086793
102Retinal dysplasia (HP:0007973)2.03797470
103Impaired social interactions (HP:0000735)2.03660039
104Abnormal social behavior (HP:0012433)2.03660039
105Methylmalonic acidemia (HP:0002912)2.02864098
106Spastic tetraparesis (HP:0001285)2.02839120
107Urinary bladder sphincter dysfunction (HP:0002839)2.00538775
108Abnormality of the musculature of the pelvis (HP:0001469)1.99699772
109Abnormality of the hip-girdle musculature (HP:0001445)1.99699772
110Widely spaced teeth (HP:0000687)1.99679713
111Broad foot (HP:0001769)1.98980362
112Postaxial hand polydactyly (HP:0001162)1.98504493
113Malignant neoplasm of the central nervous system (HP:0100836)1.97676528
114Aplasia/Hypoplasia of the lens (HP:0008063)1.97367232
115Apathy (HP:0000741)1.96831131
116Abnormality of the pancreatic islet cells (HP:0006476)1.96679611
117Abnormality of endocrine pancreas physiology (HP:0012093)1.96679611
118Annular pancreas (HP:0001734)1.96280027
119Truncal ataxia (HP:0002078)1.95513745
120Narrow forehead (HP:0000341)1.95217796
121Impaired smooth pursuit (HP:0007772)1.94970422
122Broad-based gait (HP:0002136)1.94969424
123Long foot (HP:0001833)1.94784278
124Rhabdomyosarcoma (HP:0002859)1.94414473
125Generalized myoclonic seizures (HP:0002123)1.92838089
126Abnormality of chromosome segregation (HP:0002916)1.92529477
127Nephroblastoma (Wilms tumor) (HP:0002667)1.90048612
128Shoulder girdle muscle weakness (HP:0003547)1.89773684
129Volvulus (HP:0002580)1.89458600
130Atrophy/Degeneration involving motor neurons (HP:0007373)1.87919223
131Poor suck (HP:0002033)1.87857495
132Prominent metopic ridge (HP:0005487)1.87754161
133Ketosis (HP:0001946)1.87680017
134Neuroectodermal neoplasm (HP:0030061)1.86999587
135Neuroepithelial neoplasm (HP:0030063)1.86999587
136Nervous tissue neoplasm (HP:0030060)1.86999587
137Multiple enchondromatosis (HP:0005701)1.86586858
138Open mouth (HP:0000194)1.85909708
139Abnormal eating behavior (HP:0100738)1.85668891
140Lower limb muscle weakness (HP:0007340)1.85253941
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85117182
142Mitochondrial inheritance (HP:0001427)1.84051046
143Hepatic necrosis (HP:0002605)1.83803524
144Distal upper limb amyotrophy (HP:0007149)1.83803425
145Upper limb amyotrophy (HP:0009129)1.83803425
146Ulnar claw (HP:0001178)1.83503064
147Thyroid-stimulating hormone excess (HP:0002925)1.82878605
148Hyperglycemia (HP:0003074)1.82840510
149Difficulty running (HP:0009046)1.82152609
150Abnormality of binocular vision (HP:0011514)1.81333250
151Diplopia (HP:0000651)1.81333250
152Absent speech (HP:0001344)1.81066152
153Tented upper lip vermilion (HP:0010804)1.80770843
154Hypopigmentation of the fundus (HP:0007894)1.80467848
155Urinary urgency (HP:0000012)1.80365298
156Bile duct proliferation (HP:0001408)1.80306000
157Abnormal biliary tract physiology (HP:0012439)1.80306000
158Gaze-evoked nystagmus (HP:0000640)1.79838924
159Abnormal mitochondria in muscle tissue (HP:0008316)1.79786261
160Dyskinesia (HP:0100660)1.78321864
161Papillary thyroid carcinoma (HP:0002895)1.78261050
162Intellectual disability, profound (HP:0002187)1.76874224
163Embryonal renal neoplasm (HP:0011794)1.76446634
164Insomnia (HP:0100785)1.76042133
165Achilles tendon contracture (HP:0001771)1.75985099
166Abnormality of the musculature of the hand (HP:0001421)1.74555066
167Intestinal atresia (HP:0011100)1.74547827
168Severe global developmental delay (HP:0011344)1.73715222
169Anxiety (HP:0000739)1.73640060
170Sensory axonal neuropathy (HP:0003390)1.73497115
171Hip dysplasia (HP:0001385)1.72897605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.26210496
2CDK123.96890253
3GRK53.96355446
4MAP3K93.95666276
5NTRK33.86730873
6INSRR3.09080452
7MARK12.98513622
8EPHA42.80624799
9BCR2.68064261
10TYRO32.62499946
11NTRK12.51272827
12MAP3K42.38747118
13FRK2.36315662
14MAP2K42.23672445
15PAK62.10297621
16MINK12.09285949
17NTRK22.06354352
18TRIM281.97984397
19GRK61.97173177
20ERBB31.96668073
21PRKD31.95534867
22CSNK1G31.81782840
23KSR21.80407538
24WNK11.79801697
25CSNK1G11.65032532
26DYRK21.56313242
27CSNK1A1L1.55682201
28DAPK21.50408335
29MAP2K71.49658462
30ALK1.47560174
31CCNB11.46077172
32ADRBK21.45301847
33BCKDK1.39879360
34CAMKK11.38605564
35STK381.36852262
36UHMK11.36322683
37MARK21.35717971
38BMPR1B1.30100640
39LATS21.29999879
40SRPK11.24382157
41CDK51.23684155
42GRK11.18065577
43MAPK71.14171776
44KSR11.10741571
45PRKCG1.06895982
46GRK71.06419492
47SIK21.06160012
48MOS1.05070709
49CAMK41.04415970
50ERN11.02243873
51CDK191.01390876
52MATK1.00814537
53EPHA31.00577662
54PRPF4B0.98363936
55MAP3K20.98215092
56DAPK10.97193842
57PRKCE0.96426522
58WNK30.95279569
59CDK150.94307091
60SCYL20.93211947
61TAOK10.92967551
62DYRK30.92678083
63CDK180.91838008
64TSSK60.91787688
65PHKG10.90789933
66PHKG20.90789933
67MAP3K120.87572041
68CDK140.86436451
69PRKCH0.85304173
70HIPK20.85286124
71NUAK10.83370290
72PAK30.82773561
73CDK11A0.82565603
74CSF1R0.78598427
75NEK10.75395164
76TNIK0.74949624
77DYRK1A0.74922254
78STK110.74163481
79MAPKAPK50.73720046
80OXSR10.73185396
81MAPK130.72609417
82PLK20.72501887
83VRK10.66986897
84TTK0.66704773
85FER0.66673872
86CAMK10.64660461
87MAPK100.63984797
88ADRBK10.63895820
89SGK20.63217431
90RIPK10.62622595
91MAP3K50.62270996
92MAPKAPK30.61173778
93RET0.61039678
94AKT30.60609072
95RPS6KA40.59832433
96PRKG20.59522533
97PNCK0.57838191
98MAP3K70.56619616
99CDK30.55946587
100MAP2K60.54452137
101MAP3K60.53450718
102RPS6KA30.53411000
103CDC42BPA0.51911614
104MAPK150.51308590
105TNK20.50470116
106CAMKK20.50315559
107PKN10.50315395
108PDK10.50197223
109FES0.49249106
110ARAF0.49133307
111STK390.48857764
112LMTK20.48698990
113CAMK2A0.48502633
114PRKG10.48072241
115BRSK10.47403371
116PRKCZ0.47117498
117ICK0.46612611
118FGFR20.46567313
119CSNK1E0.46419756
120PRKACB0.46140890
121CASK0.45735672
122RIPK40.45588291
123CSNK1G20.45038267
124CSNK1A10.44682879
125PDGFRA0.44657121
126PRKACA0.44599340
127EIF2AK30.44113197
128CSNK1D0.42925404
129STK38L0.41616582
130MAPK120.40763561
131MAP3K130.40089506
132RPS6KA50.39648173
133DYRK1B0.37795298
134SGK2230.37359888
135SGK4940.37359888
136GSK3B0.36715055
137SGK10.36625377
138FLT30.36394828
139LIMK10.36124422
140FYN0.35390817
141PINK10.34544829
142SIK30.33351875
143MAP3K10.32669938
144OBSCN0.30660865
145PTK20.30612643
146CAMK2B0.29923468
147PRKAA10.29860734
148EPHB20.29260197
149AKT20.28733008
150TAOK30.28068717
151YES10.27211998
152PDK20.27035665

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19616839
2Protein export_Homo sapiens_hsa030603.07244625
3Synaptic vesicle cycle_Homo sapiens_hsa047213.06702943
4GABAergic synapse_Homo sapiens_hsa047272.83574938
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.67600773
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64561208
7Long-term potentiation_Homo sapiens_hsa047202.57398378
8Glutamatergic synapse_Homo sapiens_hsa047242.50980186
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45391266
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43548673
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.34986749
12Olfactory transduction_Homo sapiens_hsa047402.33561678
13Circadian entrainment_Homo sapiens_hsa047132.32055332
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22263933
15Butanoate metabolism_Homo sapiens_hsa006502.18439996
16Amphetamine addiction_Homo sapiens_hsa050312.13084190
17Morphine addiction_Homo sapiens_hsa050322.12703050
18Oxidative phosphorylation_Homo sapiens_hsa001902.06924488
19Dopaminergic synapse_Homo sapiens_hsa047282.04059837
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99002810
21Insulin secretion_Homo sapiens_hsa049111.92943152
22Salivary secretion_Homo sapiens_hsa049701.89664452
23Fatty acid elongation_Homo sapiens_hsa000621.87189887
24Regulation of autophagy_Homo sapiens_hsa041401.85972327
25Taste transduction_Homo sapiens_hsa047421.82838001
26Propanoate metabolism_Homo sapiens_hsa006401.79250096
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.74864390
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73298175
29Long-term depression_Homo sapiens_hsa047301.73076722
30Parkinsons disease_Homo sapiens_hsa050121.68471503
31Serotonergic synapse_Homo sapiens_hsa047261.63236988
32Vitamin B6 metabolism_Homo sapiens_hsa007501.62485698
33Gastric acid secretion_Homo sapiens_hsa049711.61016995
34Cholinergic synapse_Homo sapiens_hsa047251.60813327
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53358849
36Oxytocin signaling pathway_Homo sapiens_hsa049211.50837442
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50457193
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49805442
39GnRH signaling pathway_Homo sapiens_hsa049121.49213971
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.49132400
41Renin secretion_Homo sapiens_hsa049241.48609374
42Cocaine addiction_Homo sapiens_hsa050301.47759600
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.44369931
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43260713
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42655110
46Calcium signaling pathway_Homo sapiens_hsa040201.40540383
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34078918
48Peroxisome_Homo sapiens_hsa041461.29726994
49Gap junction_Homo sapiens_hsa045401.27845183
50Circadian rhythm_Homo sapiens_hsa047101.27512723
51cAMP signaling pathway_Homo sapiens_hsa040241.26647951
52Nitrogen metabolism_Homo sapiens_hsa009101.24991502
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24935727
54Basal transcription factors_Homo sapiens_hsa030221.23044720
55Steroid biosynthesis_Homo sapiens_hsa001001.22087573
56Type II diabetes mellitus_Homo sapiens_hsa049301.21905644
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.17369978
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15818740
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15213423
60Estrogen signaling pathway_Homo sapiens_hsa049151.12841497
61Glioma_Homo sapiens_hsa052141.07629883
62Dorso-ventral axis formation_Homo sapiens_hsa043201.06812228
63ErbB signaling pathway_Homo sapiens_hsa040121.06136329
64Oocyte meiosis_Homo sapiens_hsa041141.05743129
65Alzheimers disease_Homo sapiens_hsa050101.02800474
66Axon guidance_Homo sapiens_hsa043601.02547400
67Huntingtons disease_Homo sapiens_hsa050161.00957992
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00440206
69Melanogenesis_Homo sapiens_hsa049160.99094914
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97161872
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.94635205
72Choline metabolism in cancer_Homo sapiens_hsa052310.94138640
73Fatty acid metabolism_Homo sapiens_hsa012120.94032017
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93952259
75Collecting duct acid secretion_Homo sapiens_hsa049660.92998327
76Fructose and mannose metabolism_Homo sapiens_hsa000510.91401451
77* mTOR signaling pathway_Homo sapiens_hsa041500.91218080
78beta-Alanine metabolism_Homo sapiens_hsa004100.90003262
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88599840
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87419871
81Inositol phosphate metabolism_Homo sapiens_hsa005620.84661506
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79293336
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78504193
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.76260326
85Selenocompound metabolism_Homo sapiens_hsa004500.75997628
86Ether lipid metabolism_Homo sapiens_hsa005650.75100310
87MAPK signaling pathway_Homo sapiens_hsa040100.74882889
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74449030
89VEGF signaling pathway_Homo sapiens_hsa043700.72584015
90Rap1 signaling pathway_Homo sapiens_hsa040150.72457630
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68328406
92Non-homologous end-joining_Homo sapiens_hsa034500.67767657
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67554297
94Non-small cell lung cancer_Homo sapiens_hsa052230.67382865
95Ras signaling pathway_Homo sapiens_hsa040140.67168732
96Type I diabetes mellitus_Homo sapiens_hsa049400.66903874
97Dilated cardiomyopathy_Homo sapiens_hsa054140.65960459
98Thyroid hormone synthesis_Homo sapiens_hsa049180.65423401
99Wnt signaling pathway_Homo sapiens_hsa043100.64373292
100Cardiac muscle contraction_Homo sapiens_hsa042600.63579175
101Vibrio cholerae infection_Homo sapiens_hsa051100.63056560
102Ovarian steroidogenesis_Homo sapiens_hsa049130.62724128
103Tryptophan metabolism_Homo sapiens_hsa003800.62549293
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62536406
105Linoleic acid metabolism_Homo sapiens_hsa005910.62498025
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61810659
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61632228
108Alcoholism_Homo sapiens_hsa050340.61150539
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.59636618
110Pancreatic secretion_Homo sapiens_hsa049720.59153303
111Hedgehog signaling pathway_Homo sapiens_hsa043400.58757902
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58179148
113Thyroid cancer_Homo sapiens_hsa052160.58100426
114Endometrial cancer_Homo sapiens_hsa052130.57997036
115Phototransduction_Homo sapiens_hsa047440.57870367
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.56964347
117RNA degradation_Homo sapiens_hsa030180.55189177
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55167584
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55127894
120Endocytosis_Homo sapiens_hsa041440.53359752
121Glucagon signaling pathway_Homo sapiens_hsa049220.52000267
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51221680
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50671729
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49728289
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49255143
126Sulfur relay system_Homo sapiens_hsa041220.48444336
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48420201
128Colorectal cancer_Homo sapiens_hsa052100.48293140
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47996577
130Metabolic pathways_Homo sapiens_hsa011000.47372695
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45888373
132Renal cell carcinoma_Homo sapiens_hsa052110.44900809
133Prion diseases_Homo sapiens_hsa050200.44588827
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44555928
135Bile secretion_Homo sapiens_hsa049760.43282009
136mRNA surveillance pathway_Homo sapiens_hsa030150.43064907
137Galactose metabolism_Homo sapiens_hsa000520.43019479
138Folate biosynthesis_Homo sapiens_hsa007900.42992938
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41630492
140Sulfur metabolism_Homo sapiens_hsa009200.40801389
141Fatty acid degradation_Homo sapiens_hsa000710.39899252
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.39763640
143Insulin signaling pathway_Homo sapiens_hsa049100.39478878
144Tight junction_Homo sapiens_hsa045300.39349903
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37108993
146Fanconi anemia pathway_Homo sapiens_hsa034600.36365935
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36157568
148ABC transporters_Homo sapiens_hsa020100.35931900
149RNA polymerase_Homo sapiens_hsa030200.26342616
150Carbon metabolism_Homo sapiens_hsa012000.25797519
151Chemical carcinogenesis_Homo sapiens_hsa052040.25332050

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