RRAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.55492816
2low-density lipoprotein particle clearance (GO:0034383)4.40748683
3extracellular fibril organization (GO:0043206)4.04496676
4cell migration involved in heart development (GO:0060973)3.96140111
5fibril organization (GO:0097435)3.78395445
6basement membrane organization (GO:0071711)3.78134625
7stress fiber assembly (GO:0043149)3.59853602
8type B pancreatic cell proliferation (GO:0044342)3.59327663
9retina vasculature morphogenesis in camera-type eye (GO:0061299)3.55189104
10vascular endothelial growth factor signaling pathway (GO:0038084)3.51430509
11regulation of cholesterol storage (GO:0010885)3.47202148
12protein heterotrimerization (GO:0070208)3.45282417
13apoptotic cell clearance (GO:0043277)3.34081866
14negative regulation of smooth muscle cell migration (GO:0014912)3.33627923
15cell adhesion mediated by integrin (GO:0033627)3.32030231
16protein localization to endosome (GO:0036010)3.30228181
17regulation of sequestering of triglyceride (GO:0010889)3.30056585
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24914971
19extracellular matrix assembly (GO:0085029)3.24624878
20endothelial cell morphogenesis (GO:0001886)3.18651173
21positive regulation of receptor recycling (GO:0001921)3.15756747
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.15564778
23hemidesmosome assembly (GO:0031581)3.09758293
24substrate-dependent cell migration (GO:0006929)3.07861042
25hyaluronan catabolic process (GO:0030214)3.02316107
26positive regulation of blood vessel endothelial cell migration (GO:0043536)3.00153034
27regulation of early endosome to late endosome transport (GO:2000641)2.97732879
28regulation of extracellular matrix disassembly (GO:0010715)2.97504093
29protein retention in ER lumen (GO:0006621)2.95987792
30surfactant homeostasis (GO:0043129)2.91958190
31renal filtration (GO:0097205)2.90871273
32positive regulation of extracellular matrix organization (GO:1903055)2.90290535
33positive regulation of p38MAPK cascade (GO:1900745)2.89117903
34angiogenesis involved in wound healing (GO:0060055)2.88213529
35negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87671965
36adhesion of symbiont to host (GO:0044406)2.87055535
37Golgi transport vesicle coating (GO:0048200)2.86406258
38COPI coating of Golgi vesicle (GO:0048205)2.86406258
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86250240
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84231215
41complement activation, alternative pathway (GO:0006957)2.83291001
42endodermal cell differentiation (GO:0035987)2.81075652
43cellular response to vitamin (GO:0071295)2.79553019
44keratan sulfate catabolic process (GO:0042340)2.79456376
45skin morphogenesis (GO:0043589)2.78778630
46plasma lipoprotein particle clearance (GO:0034381)2.77163636
47pinocytosis (GO:0006907)2.74953605
48sequestering of extracellular ligand from receptor (GO:0035581)2.74511142
49endothelial cell chemotaxis (GO:0035767)2.72693104
50adhesion of symbiont to host cell (GO:0044650)2.68723555
51virion attachment to host cell (GO:0019062)2.68723555
52branching involved in salivary gland morphogenesis (GO:0060445)2.67444532
53chondrocyte proliferation (GO:0035988)2.67143878
54cell-substrate junction assembly (GO:0007044)2.64632937
55brown fat cell differentiation (GO:0050873)2.64130787
56regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63583751
57collagen catabolic process (GO:0030574)2.63097093
58growth hormone receptor signaling pathway (GO:0060396)2.62948351
59positive regulation of fatty acid oxidation (GO:0046321)2.62484973
60positive regulation of endothelial cell apoptotic process (GO:2000353)2.62401664
61glomerular filtration (GO:0003094)2.61625162
62regulation of metalloenzyme activity (GO:0048552)2.61556750
63transcytosis (GO:0045056)2.61171302
64negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59898469
65positive regulation of fatty acid beta-oxidation (GO:0032000)2.59816058
66bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58795201
67wound healing, spreading of epidermal cells (GO:0035313)2.58224633
68positive regulation of lipid storage (GO:0010884)2.58136647
69venous blood vessel morphogenesis (GO:0048845)2.57812234
70peptidyl-proline hydroxylation (GO:0019511)2.57701651
71adherens junction assembly (GO:0034333)2.57432169
72hypotonic response (GO:0006971)2.57270657
73lymph vessel development (GO:0001945)2.57057295
74regulation of plasminogen activation (GO:0010755)2.55800847
75regulation of p38MAPK cascade (GO:1900744)2.55406180
76membrane raft organization (GO:0031579)2.55032200
77tooth mineralization (GO:0034505)2.54481882
78epithelial cell-cell adhesion (GO:0090136)2.54217365
79negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53193783
80response to laminar fluid shear stress (GO:0034616)2.52426147
81lymphangiogenesis (GO:0001946)2.50969636
82kidney mesenchyme development (GO:0072074)2.47480560
83fatty acid transmembrane transport (GO:1902001)2.47443611
84multicellular organismal metabolic process (GO:0044236)2.47208081
85negative regulation of protein autophosphorylation (GO:0031953)2.47111760
86multicellular organismal catabolic process (GO:0044243)2.46560427
87plasma membrane repair (GO:0001778)2.46507450
88wound healing, spreading of cells (GO:0044319)2.46200829
89negative regulation of chondrocyte differentiation (GO:0032331)2.46016993
90valine metabolic process (GO:0006573)2.46011375
91collagen fibril organization (GO:0030199)2.45931485
92focal adhesion assembly (GO:0048041)2.45116200
93cell-substrate adherens junction assembly (GO:0007045)2.45116200
94blood vessel endothelial cell migration (GO:0043534)2.45061578
95negative regulation of adherens junction organization (GO:1903392)2.44810574
96negative regulation of focal adhesion assembly (GO:0051895)2.44810574
97negative regulation of cell junction assembly (GO:1901889)2.44810574
98peptidyl-glutamic acid carboxylation (GO:0017187)2.44524464
99protein carboxylation (GO:0018214)2.44524464
100endothelium development (GO:0003158)2.44231230
101negative regulation of fibrinolysis (GO:0051918)2.44052245
102negative regulation of cardiac muscle tissue growth (GO:0055022)2.43481250
103negative regulation of heart growth (GO:0061117)2.43481250
104positive regulation of blood coagulation (GO:0030194)2.41373253
105positive regulation of hemostasis (GO:1900048)2.41373253
106glomerular basement membrane development (GO:0032836)2.41171964
107cellular response to nutrient (GO:0031670)2.40913020
108regulation of endothelial cell differentiation (GO:0045601)2.38937940
109embryo implantation (GO:0007566)2.38893776
110cortical actin cytoskeleton organization (GO:0030866)2.38841445
111cell migration involved in sprouting angiogenesis (GO:0002042)2.38626155
112glial cell migration (GO:0008347)2.38388691
113triglyceride catabolic process (GO:0019433)2.38219380
114regulation of smooth muscle cell migration (GO:0014910)2.38017145
115positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.37878186
116negative regulation of protein localization to plasma membrane (GO:1903077)2.37191193
117protein hydroxylation (GO:0018126)2.37144688
118extracellular matrix organization (GO:0030198)2.36899898
119decidualization (GO:0046697)2.36569393
120extracellular structure organization (GO:0043062)2.35878742
121detection of molecule of bacterial origin (GO:0032490)2.35833820
122protein maturation by protein folding (GO:0022417)2.35371609
123negative regulation of cartilage development (GO:0061037)2.35324390
124endocardial cushion development (GO:0003197)2.35004477
125regulation of complement activation (GO:0030449)2.34978950
126cellular response to growth hormone stimulus (GO:0071378)2.34547435
127endocytic recycling (GO:0032456)2.32814361
128regulation of integrin-mediated signaling pathway (GO:2001044)2.32111276
129negative regulation of nitric-oxide synthase activity (GO:0051001)2.31995168
130regulation of collagen metabolic process (GO:0010712)2.31943176
131alpha-linolenic acid metabolic process (GO:0036109)2.31690749
132regulation of blood vessel endothelial cell migration (GO:0043535)2.30809080
133regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.29694167
134white fat cell differentiation (GO:0050872)2.29312910
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.29009788
136positive regulation of coagulation (GO:0050820)2.28023063
137regulation of protein activation cascade (GO:2000257)2.27766779
138positive regulation of triglyceride metabolic process (GO:0090208)2.27748030
139regulation of macrophage cytokine production (GO:0010935)2.27374846
140regulation of tight junction assembly (GO:2000810)2.26494316
141negative regulation of lipid storage (GO:0010888)2.25389114
142regulation of SMAD protein import into nucleus (GO:0060390)2.23454288
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23063839
144positive regulation of lipid catabolic process (GO:0050996)2.23017431
145collagen metabolic process (GO:0032963)2.22922870
146atrioventricular valve morphogenesis (GO:0003181)2.22667040
147fatty acid beta-oxidation (GO:0006635)2.22398690
148extracellular matrix disassembly (GO:0022617)2.20461467
149negative regulation of fatty acid transport (GO:2000192)2.20204593
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.20099414
151regulation of fatty acid oxidation (GO:0046320)2.19678823
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.18771700
153fibrinolysis (GO:0042730)2.17946015
154regulation of integrin activation (GO:0033623)2.17476556
155epoxygenase P450 pathway (GO:0019373)2.16741642
156mesodermal cell differentiation (GO:0048333)2.16595616
157response to fluid shear stress (GO:0034405)2.15951252
158sarcomere organization (GO:0045214)2.15868823
159heart trabecula formation (GO:0060347)2.15388159
160regulation of fatty acid beta-oxidation (GO:0031998)2.15291979
161blood vessel maturation (GO:0001955)2.15150782
162multicellular organismal macromolecule metabolic process (GO:0044259)2.15065510
163glomerular visceral epithelial cell development (GO:0072015)2.14454004
164regulation of heterotypic cell-cell adhesion (GO:0034114)2.14154438
165negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.13861236
166positive regulation of wound healing (GO:0090303)2.13028429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.42774331
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.94846025
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.16362093
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.76437280
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.71682322
6CLOCK_20551151_ChIP-Seq_293T_Human3.12728026
7* RXR_22158963_ChIP-Seq_LIVER_Mouse2.76878226
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68997683
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.59288893
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.45399834
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39619224
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.27592666
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26318206
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21347726
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06881273
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.06317624
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.02066893
18ZNF263_19887448_ChIP-Seq_K562_Human1.97168073
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93427146
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.92465452
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.86158070
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84049657
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.81729346
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81308168
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81148492
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.81033580
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78598325
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71970450
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69543070
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61727272
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59323846
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58387647
33RACK7_27058665_Chip-Seq_MCF-7_Human1.56742736
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.54148483
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.53861266
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52916637
37* CJUN_26792858_Chip-Seq_BT549_Human1.52100840
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49266498
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.47193631
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.47193631
41VDR_21846776_ChIP-Seq_THP-1_Human1.46027857
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44234898
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40466731
44LXR_22292898_ChIP-Seq_THP-1_Human1.37453985
45SMC3_22415368_ChIP-Seq_MEFs_Mouse1.37202098
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35916214
47* SOX2_20726797_ChIP-Seq_SW620_Human1.35431307
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34968841
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34265285
50TP53_22127205_ChIP-Seq_IMR90_Human1.33781631
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.33721201
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33648502
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32966898
54* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31350219
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30879541
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.30193806
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29854263
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.28696085
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26975836
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26975836
61ATF3_27146783_Chip-Seq_COLON_Human1.25637543
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24708035
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23837805
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22779506
65KDM2B_26808549_Chip-Seq_K562_Human1.22463975
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21913287
67VDR_24763502_ChIP-Seq_THP-1_Human1.21685085
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21101431
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20778927
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18822973
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.16811568
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16768124
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16508249
74* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14983478
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14514726
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13224805
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13224805
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12949569
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11637335
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10373176
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.10353166
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.08925024
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08271087
84TCF7_22412390_ChIP-Seq_EML_Mouse1.08004737
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07370920
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07370920
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07370920
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06803858
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06532289
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.05776963
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04201840
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04062899
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03481285
94* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03137365
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02972304
96SA1_22415368_ChIP-Seq_MEFs_Mouse1.02812495
97* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02594359
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02091193
99* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00988112
100* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00119014
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00096803
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99830660
103UBF1/2_26484160_Chip-Seq_HMECs_Human0.99415118
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.99183257
105KDM2B_26808549_Chip-Seq_DND41_Human0.97662317
106IRF8_27001747_Chip-Seq_BMDM_Mouse0.97337387
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.96518489
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.96182579
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95997200
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95270373
111* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95006716
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94890626
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94846412
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94718050
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.93206630
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93136417
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92381651
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91383478
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.90458979
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90400481
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90178309
122GATA1_19941826_ChIP-Seq_K562_Human0.89370900
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.89358731
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89044295
125GATA4_25053715_ChIP-Seq_YYC3_Human0.88015627
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87532210
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86947596
128BRD4_25478319_ChIP-Seq_HGPS_Human0.86652116
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.86183139
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84871283
131* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83327103
132* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82303744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.46989015
2MP0003705_abnormal_hypodermis_morpholog3.39030942
3MP0004272_abnormal_basement_membrane3.02313313
4MP0005275_abnormal_skin_tensile2.77683918
5MP0010368_abnormal_lymphatic_system2.76895653
6MP0003279_aneurysm2.45513883
7MP0001879_abnormal_lymphatic_vessel2.29355230
8MP0003566_abnormal_cell_adhesion2.26180820
9MP0001958_emphysema2.23719792
10MP0005257_abnormal_intraocular_pressure2.23121105
11MP0005670_abnormal_white_adipose2.06283006
12MP0004130_abnormal_muscle_cell1.95781412
13MP0003191_abnormal_cellular_cholesterol1.91757306
14MP0004185_abnormal_adipocyte_glucose1.90370419
15MP0004084_abnormal_cardiac_muscle1.81842833
16MP0003724_increased_susceptibility_to1.81195141
17MP0003828_pulmonary_edema1.80533564
18MP0002837_dystrophic_cardiac_calcinosis1.77282689
19MP0000343_altered_response_to1.75870118
20MP0005503_abnormal_tendon_morphology1.72475946
21MP0005666_abnormal_adipose_tissue1.68241121
22MP0006054_spinal_hemorrhage1.62927399
23MP0005023_abnormal_wound_healing1.60166271
24MP0005360_urolithiasis1.57411490
25MP0009840_abnormal_foam_cell1.53247086
26MP0000767_abnormal_smooth_muscle1.49531911
27MP0002295_abnormal_pulmonary_circulatio1.46271663
28MP0005623_abnormal_meninges_morphology1.46028271
29MP0008775_abnormal_heart_ventricle1.44789877
30MP0000750_abnormal_muscle_regeneration1.43612013
31MP0006138_congestive_heart_failure1.40563346
32MP0001849_ear_inflammation1.37568792
33MP0005330_cardiomyopathy1.36514407
34MP0002139_abnormal_hepatobiliary_system1.35679608
35MP0010030_abnormal_orbit_morphology1.35090230
36MP0003091_abnormal_cell_migration1.33064723
37MP0003950_abnormal_plasma_membrane1.30859573
38MP0005375_adipose_tissue_phenotype1.30850033
39MP0005167_abnormal_blood-brain_barrier1.28565804
40MP0010329_abnormal_lipoprotein_level1.28032586
41MP0004858_abnormal_nervous_system1.27618777
42MP0005083_abnormal_biliary_tract1.27485005
43MP0004036_abnormal_muscle_relaxation1.24814580
44MP0001544_abnormal_cardiovascular_syste1.24078950
45MP0005385_cardiovascular_system_phenoty1.24078950
46MP0004087_abnormal_muscle_fiber1.23714049
47MP0002060_abnormal_skin_morphology1.22271619
48MP0009278_abnormal_bone_marrow1.22263997
49MP0010352_gastrointestinal_tract_polyps1.22200777
50MP0010630_abnormal_cardiac_muscle1.21156087
51MP0003045_fibrosis1.20601406
52MP0000751_myopathy1.18177099
53MP0003300_gastrointestinal_ulcer1.16128415
54MP0001533_abnormal_skeleton_physiology1.12864248
55* MP0000249_abnormal_blood_vessel1.12245657
56MP0000733_abnormal_muscle_development1.12180109
57* MP0005164_abnormal_response_to1.09690632
58MP0005058_abnormal_lysosome_morphology1.09114236
59MP0000013_abnormal_adipose_tissue1.07038062
60MP0003186_abnormal_redox_activity1.06511143
61MP0002972_abnormal_cardiac_muscle1.06175428
62MP0001243_abnormal_dermal_layer1.05610710
63MP0008260_abnormal_autophagy1.05593926
64MP0005409_darkened_coat_color1.05118412
65MP0009384_cardiac_valve_regurgitation1.04738396
66MP0002254_reproductive_system_inflammat1.04672389
67MP0003436_decreased_susceptibility_to1.03631063
68MP0002108_abnormal_muscle_morphology1.01386024
69MP0002128_abnormal_blood_circulation1.00394776
70MP0005464_abnormal_platelet_physiology0.99590313
71MP0005451_abnormal_body_composition0.99009336
72MP0003448_altered_tumor_morphology0.95836512
73MP0005165_increased_susceptibility_to0.95585281
74MP0003453_abnormal_keratinocyte_physiol0.95158690
75MP0002138_abnormal_hepatobiliary_system0.94623536
76MP0000749_muscle_degeneration0.94503147
77MP0009053_abnormal_anal_canal0.94407278
78MP0002168_other_aberrant_phenotype0.93346639
79MP0005085_abnormal_gallbladder_physiolo0.93028032
80MP0008875_abnormal_xenobiotic_pharmacok0.92316131
81MP0003252_abnormal_bile_duct0.91943443
82* MP0001614_abnormal_blood_vessel0.91290999
83MP0005595_abnormal_vascular_smooth0.91193920
84MP0005620_abnormal_muscle_contractility0.91183834
85MP0002998_abnormal_bone_remodeling0.90967513
86MP0001542_abnormal_bone_strength0.89812675
87MP0005365_abnormal_bile_salt0.88788917
88MP0005508_abnormal_skeleton_morphology0.88273474
89MP0000003_abnormal_adipose_tissue0.87017338
90MP0002971_abnormal_brown_adipose0.86721357
91MP0000858_altered_metastatic_potential0.85245749
92MP0002877_abnormal_melanocyte_morpholog0.85181843
93MP0002166_altered_tumor_susceptibility0.84968276
94MP0002118_abnormal_lipid_homeostasis0.84226525
95MP0005319_abnormal_enzyme/_coenzyme0.84025649
96MP0002796_impaired_skin_barrier0.83707458
97MP0000609_abnormal_liver_physiology0.83625214
98MP0009764_decreased_sensitivity_to0.83592607
99MP0008004_abnormal_stomach_pH0.82371156
100MP0002332_abnormal_exercise_endurance0.82280656
101MP0005390_skeleton_phenotype0.82197577
102MP0003303_peritoneal_inflammation0.82057586
103MP0006082_CNS_inflammation0.81952554
104MP0009785_altered_susceptibility_to0.80354920
105MP0004510_myositis0.80160129
106MP0003795_abnormal_bone_structure0.79051911
107MP0009643_abnormal_urine_homeostasis0.78372787
108MP0000685_abnormal_immune_system0.77639617
109MP0004947_skin_inflammation0.77442776
110MP0005332_abnormal_amino_acid0.77368278
111MP0009115_abnormal_fat_cell0.76692721
112MP0002933_joint_inflammation0.76591408
113MP0000762_abnormal_tongue_morphology0.76308572
114MP0000604_amyloidosis0.75993137
115MP0003075_altered_response_to0.74246388
116MP0003329_amyloid_beta_deposits0.73807223
117MP0002896_abnormal_bone_mineralization0.73738303
118MP0000759_abnormal_skeletal_muscle0.73260835
119MP0000163_abnormal_cartilage_morphology0.72574761
120MP0001348_abnormal_lacrimal_gland0.71584238
121MP0005166_decreased_susceptibility_to0.70584989
122MP0001661_extended_life_span0.70119913
123MP0002113_abnormal_skeleton_development0.70061437
124MP0000747_muscle_weakness0.69459063
125MP0009780_abnormal_chondrocyte_physiolo0.68104384
126MP0002148_abnormal_hypersensitivity_rea0.68093163
127MP0005501_abnormal_skin_physiology0.68087390
128MP0002419_abnormal_innate_immunity0.62466930
129MP0002133_abnormal_respiratory_system0.61153972
130MP0005388_respiratory_system_phenotype0.61153972

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.79886274
2Premature rupture of membranes (HP:0001788)4.47937018
3Broad metatarsal (HP:0001783)3.86072580
4Right ventricular cardiomyopathy (HP:0011663)3.69177085
5Increased connective tissue (HP:0009025)3.53376112
6Cerebral aneurysm (HP:0004944)3.50195591
7Aortic dissection (HP:0002647)3.46515848
8Aortic aneurysm (HP:0004942)3.33927244
9Ankle contracture (HP:0006466)3.33039393
10Muscle fiber splitting (HP:0003555)3.20856193
11Hyporeflexia of lower limbs (HP:0002600)3.05476147
12Type 1 muscle fiber predominance (HP:0003803)3.05192360
13Polycythemia (HP:0001901)3.05042546
14Deep venous thrombosis (HP:0002625)3.04626099
15Atrophic scars (HP:0001075)3.03719957
16Peritonitis (HP:0002586)3.01325994
17Shallow orbits (HP:0000586)3.00957976
18Spondylolisthesis (HP:0003302)2.83270718
19Slender build (HP:0001533)2.75181819
20Spinal rigidity (HP:0003306)2.73555949
21Complement deficiency (HP:0004431)2.68711934
22Abnormality of dentin (HP:0010299)2.64808370
23Joint stiffness (HP:0001387)2.62401130
24Abnormality of liposaccharide metabolism (HP:0010968)2.61229761
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.61229761
26Abnormality of glycolipid metabolism (HP:0010969)2.61229761
27Xanthomatosis (HP:0000991)2.59397886
28Myocardial infarction (HP:0001658)2.59050307
29Dysostosis multiplex (HP:0000943)2.58623410
30Ventricular tachycardia (HP:0004756)2.58174682
31Systemic lupus erythematosus (HP:0002725)2.54865702
32Genu recurvatum (HP:0002816)2.52548020
33Aneurysm (HP:0002617)2.51829898
34Esophageal varix (HP:0002040)2.48577201
35Hemorrhage of the eye (HP:0011885)2.43363725
36Exercise-induced muscle cramps (HP:0003710)2.38158341
37Mitral regurgitation (HP:0001653)2.37847442
38Osteolytic defects of the hand bones (HP:0009699)2.37023533
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.37023533
40Distal lower limb amyotrophy (HP:0008944)2.36789993
41Lipoatrophy (HP:0100578)2.36371296
42Vertebral compression fractures (HP:0002953)2.36084544
43Hematochezia (HP:0002573)2.34969127
44Abnormal hemoglobin (HP:0011902)2.34226689
45Fragile skin (HP:0001030)2.34122771
46Increased variability in muscle fiber diameter (HP:0003557)2.33943485
47Acanthosis nigricans (HP:0000956)2.33195073
48Mitral valve prolapse (HP:0001634)2.32925363
49Biconcave vertebral bodies (HP:0004586)2.28501112
50Cervical subluxation (HP:0003308)2.27827874
51Asymmetric septal hypertrophy (HP:0001670)2.27609545
52Mucopolysacchariduria (HP:0008155)2.27081120
53Urinary glycosaminoglycan excretion (HP:0003541)2.27081120
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26632101
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26632101
56Abnormality of polysaccharide metabolism (HP:0011012)2.26632101
57Sudden death (HP:0001699)2.25937540
58Aortic regurgitation (HP:0001659)2.25145145
59Blue sclerae (HP:0000592)2.24496083
60Abnormality of complement system (HP:0005339)2.24413497
61Nephritis (HP:0000123)2.23662446
62Joint laxity (HP:0001388)2.22720424
63Thin bony cortex (HP:0002753)2.21276800
64Axonal loss (HP:0003447)2.21016437
65Dilatation of the ascending aorta (HP:0005111)2.20798860
66Interstitial pulmonary disease (HP:0006530)2.20510385
67Short nail (HP:0001799)2.19982759
68Achilles tendon contracture (HP:0001771)2.19251730
69Upper limb amyotrophy (HP:0009129)2.18911255
70Distal upper limb amyotrophy (HP:0007149)2.18911255
71Nonimmune hydrops fetalis (HP:0001790)2.13856504
72Neonatal short-limb short stature (HP:0008921)2.13632028
73Vascular tortuosity (HP:0004948)2.12808029
74Abnormality of skeletal muscle fiber size (HP:0012084)2.09628421
75Aortic valve stenosis (HP:0001650)2.09380249
76Round ear (HP:0100830)2.09120831
77Mesangial abnormality (HP:0001966)2.07651113
78Ulnar bowing (HP:0003031)2.07240144
79Nuclear cataract (HP:0100018)2.04276105
80Reduced subcutaneous adipose tissue (HP:0003758)2.04177967
81Abnormality of the acetabulum (HP:0003170)2.03598721
82Bone cyst (HP:0012062)2.03332148
83Hyperextensible skin (HP:0000974)2.03247143
84Difficulty running (HP:0009046)2.02497036
85Hyperlipoproteinemia (HP:0010980)2.02354008
86Abnormality of the Achilles tendon (HP:0005109)2.01456564
87Wrist flexion contracture (HP:0001239)2.01118779
88Camptodactyly of toe (HP:0001836)1.99589488
89Disproportionate tall stature (HP:0001519)1.98722427
90Abnormal cartilage morphology (HP:0002763)1.96840517
91Ovoid vertebral bodies (HP:0003300)1.95625778
92Hypoalphalipoproteinemia (HP:0003233)1.95553245
93Emphysema (HP:0002097)1.94966419
94Wormian bones (HP:0002645)1.93193338
95Spontaneous hematomas (HP:0007420)1.92162635
96Generalized amyotrophy (HP:0003700)1.92102248
97Pulmonary artery stenosis (HP:0004415)1.91249471
98Lymphangioma (HP:0100764)1.89891062
99Short hallux (HP:0010109)1.89648502
100Difficulty climbing stairs (HP:0003551)1.88899392
101Turricephaly (HP:0000262)1.88697544
102Mildly elevated creatine phosphokinase (HP:0008180)1.87951901
103Ulnar deviation of the wrist (HP:0003049)1.87066609
104Cardiovascular calcification (HP:0011915)1.85754479
105Chondrocalcinosis (HP:0000934)1.85709901
106Soft skin (HP:0000977)1.85705816
107Bladder diverticulum (HP:0000015)1.85223439
108Myoglobinuria (HP:0002913)1.84959111
109Bowel diverticulosis (HP:0005222)1.82629745
110Abnormality of proline metabolism (HP:0010907)1.82483920
111Hydroxyprolinuria (HP:0003080)1.82483920
112Amyloidosis (HP:0011034)1.81618567
113Stridor (HP:0010307)1.81366475
114Coxa vara (HP:0002812)1.80970072
115EMG: myopathic abnormalities (HP:0003458)1.80103515
116Elbow flexion contracture (HP:0002987)1.79213245
117Scapular winging (HP:0003691)1.77878327
118Abnormal delivery (HP:0001787)1.77731521
119Venous abnormality (HP:0002624)1.77598344
120Follicular hyperkeratosis (HP:0007502)1.77054342
121Natal tooth (HP:0000695)1.76587721
122Ectopia lentis (HP:0001083)1.76271417
123Bronchomalacia (HP:0002780)1.76201914
124Flat acetabular roof (HP:0003180)1.76004140
125Bowing of the arm (HP:0006488)1.75788395
126Bowed forearm bones (HP:0003956)1.75788395
127Skin nodule (HP:0200036)1.74906358
128Abnormality of the nasal mucosa (HP:0000433)1.74565193
129Distal lower limb muscle weakness (HP:0009053)1.73942385
130Arterial tortuosity (HP:0005116)1.73499236
131Rectal prolapse (HP:0002035)1.73489486
132Aplasia/Hypoplasia of the hallux (HP:0008362)1.72927265
133Purpura (HP:0000979)1.71845215
134Mitral stenosis (HP:0001718)1.71716341
135Overgrowth (HP:0001548)1.71267998
136Hypertriglyceridemia (HP:0002155)1.70629172
137Tetraparesis (HP:0002273)1.70429266
138Abnormality of Sharpey fibers (HP:0100685)1.68358648
139Myotonia (HP:0002486)1.68346024
140Beaking of vertebral bodies (HP:0004568)1.68258106
141Broad face (HP:0000283)1.68160909
142Hypoventilation (HP:0002791)1.60758738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.97958051
2ERN13.40996039
3TTN3.17109681
4TIE13.08244022
5MYLK2.68987802
6PKN22.29073655
7KDR2.27574294
8TGFBR22.23845077
9IRAK32.21092379
10RIPK12.20693930
11EPHB12.12262990
12SIK11.98903409
13EPHA21.83944151
14ARAF1.78007493
15PDGFRA1.75659101
16NME21.72986187
17FGFR41.70227021
18BCKDK1.68641470
19MAP2K31.66980901
20LRRK21.62760977
21PRPF4B1.61195888
22CDC42BPA1.60620526
23MET1.58428686
24PTK61.53580053
25DDR21.49748356
26BMX1.47856999
27MST1R1.47782706
28MAP3K31.44945519
29DMPK1.44703337
30LATS11.42750225
31TAOK21.40764161
32PRKD21.39255328
33EPHA31.36580350
34TGFBR11.26700082
35TBK11.25807931
36CAMK1D1.23891918
37LATS21.21744428
38ILK1.20513757
39NEK91.19035209
40PTK21.13955027
41PAK41.07581870
42MAP3K61.04914591
43FER1.03317343
44PTK2B1.02857762
45PAK21.02521314
46PIM21.01896334
47TYK20.99472319
48MAPKAPK30.99339105
49TRPM70.98500804
50* EPHB20.98464036
51MAP2K10.92153871
52JAK30.91147785
53CSK0.90959872
54MAP2K20.90466014
55SMG10.90195141
56PIK3CA0.88880753
57STK100.88355090
58ICK0.85911755
59MAP3K130.85307791
60MST40.85141268
61DAPK30.84033962
62TESK20.83949437
63MAP3K140.83905104
64BLK0.83901710
65FGFR30.82777040
66STK380.82103616
67STK30.81766875
68LMTK20.81590590
69ABL20.81087764
70JAK10.80968991
71RPS6KA20.80264818
72PRKD10.77331689
73GRK70.77269838
74MAPK70.76744996
75GRK50.73229189
76ROCK10.72885042
77PDGFRB0.71656925
78MAP3K110.71379268
79PRKG20.69168629
80TESK10.66818884
81LIMK10.66570276
82RET0.65852590
83CDK60.65643167
84KIT0.65448688
85PDK20.64652861
86RPS6KA40.62354483
87STK38L0.61667716
88PAK10.61466118
89PAK30.60871104
90PIK3CG0.59602410
91BRAF0.58402049
92ADRBK10.58205378
93MATK0.57732492
94CAMK1G0.57471572
95FLT30.57407347
96MAP3K120.56967059
97KSR20.56362966
98PRKAA20.54475134
99RPS6KC10.54473905
100RPS6KL10.54473905
101MARK20.54246707
102OBSCN0.54175285
103MAP3K70.52523769
104MTOR0.52268106
105GSK3A0.52132735
106TAOK10.50953132
107ROCK20.50188791
108JAK20.49878348
109IKBKB0.48349760
110FGFR10.47986128
111MAP3K10.47243266
112NTRK10.47016935
113ZAP700.46415701
114MOS0.44354856
115CAMK2G0.44279648
116HIPK20.43975090
117PRKD30.43919473
118NLK0.41912775
119WNK40.41685194
120EGFR0.41680058
121MAPK120.41674207
122FGFR20.41502840
123MAPK40.41078403
124PDPK10.40943550
125IKBKE0.40269015
126ERBB40.39715835
127CHUK0.38954265
128MAPKAPK20.38828658
129MAP3K80.38395795
130MARK30.38329690
131PDK30.36311446
132RPS6KA60.35420709
133MUSK0.30674012

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.85006910
2PPAR signaling pathway_Homo sapiens_hsa033202.31075951
3ECM-receptor interaction_Homo sapiens_hsa045122.30436041
4Staphylococcus aureus infection_Homo sapiens_hsa051502.24717204
5Caffeine metabolism_Homo sapiens_hsa002322.20500616
6Complement and coagulation cascades_Homo sapiens_hsa046102.14682374
7Fatty acid degradation_Homo sapiens_hsa000712.11702479
8Focal adhesion_Homo sapiens_hsa045101.79965310
9Fatty acid metabolism_Homo sapiens_hsa012121.72342334
10Amoebiasis_Homo sapiens_hsa051461.72228947
11Galactose metabolism_Homo sapiens_hsa000521.72106384
12Malaria_Homo sapiens_hsa051441.71087742
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64522119
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62703977
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59463714
16Sulfur metabolism_Homo sapiens_hsa009201.54990696
17Propanoate metabolism_Homo sapiens_hsa006401.54929480
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48501281
19Nitrogen metabolism_Homo sapiens_hsa009101.47668221
20Arginine biosynthesis_Homo sapiens_hsa002201.43887233
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43651177
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35633149
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.34428477
24Adherens junction_Homo sapiens_hsa045201.33432865
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33024821
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30979125
27* Proteoglycans in cancer_Homo sapiens_hsa052051.29805514
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25405139
29Tryptophan metabolism_Homo sapiens_hsa003801.25268002
30Fatty acid biosynthesis_Homo sapiens_hsa000611.24522379
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24444543
32Dilated cardiomyopathy_Homo sapiens_hsa054141.24132353
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.23930774
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.23798769
35Leishmaniasis_Homo sapiens_hsa051401.21772877
36Toxoplasmosis_Homo sapiens_hsa051451.19204764
37Chemical carcinogenesis_Homo sapiens_hsa052041.17978723
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17331286
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17062450
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16226441
41Sulfur relay system_Homo sapiens_hsa041221.15967106
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14140693
43Small cell lung cancer_Homo sapiens_hsa052221.13258189
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13057362
45Pertussis_Homo sapiens_hsa051331.12327701
46Bladder cancer_Homo sapiens_hsa052191.11259769
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08606838
48Fructose and mannose metabolism_Homo sapiens_hsa000511.07410187
49Peroxisome_Homo sapiens_hsa041461.02538414
50Viral myocarditis_Homo sapiens_hsa054160.98341771
51Phenylalanine metabolism_Homo sapiens_hsa003600.97796699
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97534659
53Vibrio cholerae infection_Homo sapiens_hsa051100.97450801
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.96966146
55Carbon metabolism_Homo sapiens_hsa012000.96192034
56Endocytosis_Homo sapiens_hsa041440.95970862
57beta-Alanine metabolism_Homo sapiens_hsa004100.94376511
58Insulin resistance_Homo sapiens_hsa049310.93829548
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91117206
60Starch and sucrose metabolism_Homo sapiens_hsa005000.89816208
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87618035
62Lysosome_Homo sapiens_hsa041420.86550718
63Renin-angiotensin system_Homo sapiens_hsa046140.84631433
64Fat digestion and absorption_Homo sapiens_hsa049750.84035932
65Tyrosine metabolism_Homo sapiens_hsa003500.82730293
66Pyruvate metabolism_Homo sapiens_hsa006200.82584350
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82047301
68Osteoclast differentiation_Homo sapiens_hsa043800.79613407
69TNF signaling pathway_Homo sapiens_hsa046680.79141374
70Salmonella infection_Homo sapiens_hsa051320.79122528
71TGF-beta signaling pathway_Homo sapiens_hsa043500.79002850
72Legionellosis_Homo sapiens_hsa051340.78245927
73Pancreatic cancer_Homo sapiens_hsa052120.78215408
74Protein digestion and absorption_Homo sapiens_hsa049740.77998359
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76211950
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75268287
77Glycerolipid metabolism_Homo sapiens_hsa005610.75186455
78HIF-1 signaling pathway_Homo sapiens_hsa040660.74853993
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74705812
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72583901
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72477076
82* Phospholipase D signaling pathway_Homo sapiens_hsa040720.71580310
83Bile secretion_Homo sapiens_hsa049760.71415093
84* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68995555
85Fatty acid elongation_Homo sapiens_hsa000620.68394091
86Chronic myeloid leukemia_Homo sapiens_hsa052200.66611294
87Rheumatoid arthritis_Homo sapiens_hsa053230.65992410
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.65823072
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65693157
90Prion diseases_Homo sapiens_hsa050200.64817164
91Histidine metabolism_Homo sapiens_hsa003400.64349582
92* Tight junction_Homo sapiens_hsa045300.63557053
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.63318648
94Glutathione metabolism_Homo sapiens_hsa004800.63280411
95Platelet activation_Homo sapiens_hsa046110.62306065
96Hippo signaling pathway_Homo sapiens_hsa043900.61735154
97Arginine and proline metabolism_Homo sapiens_hsa003300.60872881
98Mineral absorption_Homo sapiens_hsa049780.60116995
99Tuberculosis_Homo sapiens_hsa051520.59634126
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59034626
101Acute myeloid leukemia_Homo sapiens_hsa052210.58483316
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.58421291
103GnRH signaling pathway_Homo sapiens_hsa049120.57693717
104AMPK signaling pathway_Homo sapiens_hsa041520.56743384
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.56611588
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56464799
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56202417
108Pentose phosphate pathway_Homo sapiens_hsa000300.56102205
109Insulin signaling pathway_Homo sapiens_hsa049100.56009609
110Retinol metabolism_Homo sapiens_hsa008300.55905809
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55728960
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54661025
113Renal cell carcinoma_Homo sapiens_hsa052110.54133354
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53828858
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53789489
116Shigellosis_Homo sapiens_hsa051310.53537382
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53528124
118Phagosome_Homo sapiens_hsa041450.53000593
119Apoptosis_Homo sapiens_hsa042100.52899642
120Hematopoietic cell lineage_Homo sapiens_hsa046400.52569802
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.51381991
122Other glycan degradation_Homo sapiens_hsa005110.51092894
123Melanoma_Homo sapiens_hsa052180.51038951
124Gap junction_Homo sapiens_hsa045400.49455463
125Sphingolipid metabolism_Homo sapiens_hsa006000.49440880
126Notch signaling pathway_Homo sapiens_hsa043300.48595180
127* Rap1 signaling pathway_Homo sapiens_hsa040150.47256145
128Pathways in cancer_Homo sapiens_hsa052000.46856771
129Hepatitis C_Homo sapiens_hsa051600.46548910
130VEGF signaling pathway_Homo sapiens_hsa043700.46125408
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.45812271
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45523333
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.44638792
134Influenza A_Homo sapiens_hsa051640.44444599
135Hepatitis B_Homo sapiens_hsa051610.44100900
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43649701
137Chemokine signaling pathway_Homo sapiens_hsa040620.43585926
138Thyroid cancer_Homo sapiens_hsa052160.43284364
139* HTLV-I infection_Homo sapiens_hsa051660.42009829
140African trypanosomiasis_Homo sapiens_hsa051430.40923138
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.40617044
142Estrogen signaling pathway_Homo sapiens_hsa049150.40508134

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