RRBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)4.35397196
2hemidesmosome assembly (GO:0031581)4.22858517
3regulation of apoptotic cell clearance (GO:2000425)3.91070829
4peptidyl-glutamic acid carboxylation (GO:0017187)3.87720576
5protein carboxylation (GO:0018214)3.87720576
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79252950
7negative regulation of fibrinolysis (GO:0051918)3.69677027
8sulfur amino acid catabolic process (GO:0000098)3.65954567
9L-phenylalanine catabolic process (GO:0006559)3.63660771
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63660771
11cell-substrate junction assembly (GO:0007044)3.63556076
12very-low-density lipoprotein particle assembly (GO:0034379)3.60563374
13bile acid and bile salt transport (GO:0015721)3.58949265
14desmosome organization (GO:0002934)3.56884719
15negative regulation of fatty acid transport (GO:2000192)3.54794959
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53803591
17L-phenylalanine metabolic process (GO:0006558)3.53803591
18positive regulation of extracellular matrix organization (GO:1903055)3.52448472
19regulation of cholesterol homeostasis (GO:2000188)3.52121870
20low-density lipoprotein particle clearance (GO:0034383)3.48191193
21COPI coating of Golgi vesicle (GO:0048205)3.44607579
22Golgi transport vesicle coating (GO:0048200)3.44607579
234-hydroxyproline metabolic process (GO:0019471)3.43985502
24complement activation, alternative pathway (GO:0006957)3.43312206
25alpha-linolenic acid metabolic process (GO:0036109)3.42808471
26apoptotic cell clearance (GO:0043277)3.40317130
27intestinal absorption (GO:0050892)3.38876213
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38602277
29homocysteine metabolic process (GO:0050667)3.32866478
30plasma lipoprotein particle clearance (GO:0034381)3.31357681
31regulation of protein activation cascade (GO:2000257)3.29294000
32positive regulation of fatty acid beta-oxidation (GO:0032000)3.25839501
33regulation of extracellular matrix disassembly (GO:0010715)3.25054849
34regulation of fibrinolysis (GO:0051917)3.23131324
35cysteine metabolic process (GO:0006534)3.20671612
36protein retention in ER lumen (GO:0006621)3.18194211
37regulation of complement activation (GO:0030449)3.16734723
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16299743
39lipoprotein metabolic process (GO:0042157)3.13792878
40regulation of triglyceride catabolic process (GO:0010896)3.13389407
41COPII vesicle coating (GO:0048208)3.11980678
42high-density lipoprotein particle remodeling (GO:0034375)3.11761781
43pinocytosis (GO:0006907)3.09650921
44urea cycle (GO:0000050)3.09353355
45urea metabolic process (GO:0019627)3.09353355
46protein localization to endosome (GO:0036010)3.06760675
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05102216
48adherens junction assembly (GO:0034333)3.04414814
49reverse cholesterol transport (GO:0043691)3.04054928
50aromatic amino acid family catabolic process (GO:0009074)3.03364445
51phospholipid homeostasis (GO:0055091)3.02392494
52negative regulation of sterol transport (GO:0032372)3.02175935
53negative regulation of cholesterol transport (GO:0032375)3.02175935
54cell-substrate adherens junction assembly (GO:0007045)2.99287799
55focal adhesion assembly (GO:0048041)2.99287799
56epithelial cell-cell adhesion (GO:0090136)2.98709990
57chondrocyte proliferation (GO:0035988)2.96532243
58regulation of fatty acid beta-oxidation (GO:0031998)2.96030838
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95888019
60regulation of extracellular matrix organization (GO:1903053)2.95860839
61phospholipid efflux (GO:0033700)2.94210150
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91802319
63positive regulation of lipid catabolic process (GO:0050996)2.88919406
64endocardial cushion development (GO:0003197)2.88451107
65protein-lipid complex remodeling (GO:0034368)2.86726377
66macromolecular complex remodeling (GO:0034367)2.86726377
67plasma lipoprotein particle remodeling (GO:0034369)2.86726377
68regulation of cholesterol storage (GO:0010885)2.84860884
69glyoxylate metabolic process (GO:0046487)2.84616425
70epoxygenase P450 pathway (GO:0019373)2.83546043
71cholesterol homeostasis (GO:0042632)2.83421655
72sterol homeostasis (GO:0055092)2.83402292
73lysine catabolic process (GO:0006554)2.83323171
74lysine metabolic process (GO:0006553)2.83323171
75skin morphogenesis (GO:0043589)2.82804416
76regulation of plasminogen activation (GO:0010755)2.82575167
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82543627
78kynurenine metabolic process (GO:0070189)2.82043526
79positive regulation of p38MAPK cascade (GO:1900745)2.80994580
80protein-lipid complex assembly (GO:0065005)2.80896625
81positive regulation of nuclease activity (GO:0032075)2.80331984
82acylglycerol homeostasis (GO:0055090)2.80083763
83triglyceride homeostasis (GO:0070328)2.80083763
84hypotonic response (GO:0006971)2.79976440
85endodermal cell differentiation (GO:0035987)2.79197660
86regulation of cholesterol biosynthetic process (GO:0045540)2.77268904
87nitrogen cycle metabolic process (GO:0071941)2.76515399
88transcytosis (GO:0045056)2.74506424
89basement membrane organization (GO:0071711)2.74306985
90positive regulation of lipoprotein lipase activity (GO:0051006)2.73887489
91positive regulation of triglyceride lipase activity (GO:0061365)2.73887489
92low-density lipoprotein particle remodeling (GO:0034374)2.73808235
93cell adhesion mediated by integrin (GO:0033627)2.73328708
94endothelial cell morphogenesis (GO:0001886)2.72143443
95plasma lipoprotein particle assembly (GO:0034377)2.71668442
96positive regulation of endothelial cell apoptotic process (GO:2000353)2.71610660
97collagen fibril organization (GO:0030199)2.71275075
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.70614258
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70349503
100positive regulation of fatty acid oxidation (GO:0046321)2.70233712
101cellular modified amino acid catabolic process (GO:0042219)2.69787763
102positive regulation of triglyceride metabolic process (GO:0090208)2.69531926
103surfactant homeostasis (GO:0043129)2.69302390
104semaphorin-plexin signaling pathway (GO:0071526)2.68777059
105bile acid metabolic process (GO:0008206)2.68073021
106extracellular matrix disassembly (GO:0022617)2.67980267
107collagen metabolic process (GO:0032963)2.65904362
108endoplasmic reticulum unfolded protein response (GO:0030968)2.65143043
109regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.65031777
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64646147
111mesodermal cell differentiation (GO:0048333)2.63073430
112acute-phase response (GO:0006953)2.62266612
113fibrinolysis (GO:0042730)2.61958728
114bile acid biosynthetic process (GO:0006699)2.61888111
115barbed-end actin filament capping (GO:0051016)2.59442913
116branching involved in mammary gland duct morphogenesis (GO:0060444)2.59358689
117cholesterol efflux (GO:0033344)2.59348241
118peptidyl-proline hydroxylation (GO:0019511)2.57979176
119exocrine pancreas development (GO:0031017)2.57553139
120adhesion of symbiont to host (GO:0044406)2.57068709
121vascular endothelial growth factor signaling pathway (GO:0038084)2.56408367
122multicellular organismal macromolecule metabolic process (GO:0044259)2.56357430
123negative regulation of lipid transport (GO:0032369)2.56327684
124protein heterotrimerization (GO:0070208)2.55968482
125proline biosynthetic process (GO:0006561)2.55263320
126cellular glucuronidation (GO:0052695)2.54431896
127cellular response to unfolded protein (GO:0034620)2.53420593
128regulation of glucose import in response to insulin stimulus (GO:2001273)2.53397876
129regulation of nuclease activity (GO:0032069)2.53167071
130negative regulation of protein activation cascade (GO:2000258)2.52441600
131tryptophan catabolic process (GO:0006569)2.51779556
132indole-containing compound catabolic process (GO:0042436)2.51779556
133indolalkylamine catabolic process (GO:0046218)2.51779556
134plasma lipoprotein particle organization (GO:0071827)2.51590134
135tryptophan metabolic process (GO:0006568)2.51370166
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.51265756
137hyaluronan catabolic process (GO:0030214)2.50572377
138positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49945802
139negative regulation of blood coagulation (GO:0030195)2.49848213
140negative regulation of hemostasis (GO:1900047)2.49848213
141mannose metabolic process (GO:0006013)2.48535864
142positive regulation of osteoblast proliferation (GO:0033690)2.48462212
143collagen catabolic process (GO:0030574)2.48148290
144protein-lipid complex subunit organization (GO:0071825)2.47596070
145stress fiber assembly (GO:0043149)2.47513455
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47354566
147regulation of cholesterol esterification (GO:0010872)2.46493908
148ER-nucleus signaling pathway (GO:0006984)2.46368851
149regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45875081
150proline metabolic process (GO:0006560)2.45624158
151embryonic process involved in female pregnancy (GO:0060136)2.44387583
152multicellular organismal metabolic process (GO:0044236)2.43386722
153actin filament depolymerization (GO:0030042)2.43300321
154positive regulation of fatty acid biosynthetic process (GO:0045723)2.42717670
155complement activation, classical pathway (GO:0006958)2.42504255
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40218568
157hyaluronan metabolic process (GO:0030212)2.39953096
158negative regulation of coagulation (GO:0050819)2.39280545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.07212986
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.54868278
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.20014231
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.14672972
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.88093091
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62778793
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.86341214
8CLOCK_20551151_ChIP-Seq_293T_Human2.85603034
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79698488
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79375605
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63678900
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59696079
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46912272
14* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45642392
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04419875
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03403923
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00487207
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96004527
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90951516
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.88906518
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.88793388
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87011129
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.82413639
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81870156
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72745462
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67867471
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66209724
28* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64261469
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61358817
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.60895596
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.59807166
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59684238
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54182462
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52954753
35* GATA6_25053715_ChIP-Seq_YYC3_Human1.52654487
36* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51167167
37RACK7_27058665_Chip-Seq_MCF-7_Human1.51113349
38* GATA4_25053715_ChIP-Seq_YYC3_Human1.49295607
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47955013
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47549804
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47194827
42KDM2B_26808549_Chip-Seq_K562_Human1.46625943
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.46426248
44* TP53_22127205_ChIP-Seq_IMR90_Human1.43846111
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43477259
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40915832
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39211029
48ATF3_27146783_Chip-Seq_COLON_Human1.38910312
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.36463554
50LXR_22292898_ChIP-Seq_THP-1_Human1.35953405
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34348828
52SOX2_20726797_ChIP-Seq_SW620_Human1.31986073
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31148211
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30662243
55* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30458223
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30090226
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28065762
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24758910
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24486867
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22306070
61AR_21909140_ChIP-Seq_LNCAP_Human1.21286451
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20526583
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17580473
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.17340247
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.17340247
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16715942
67ZNF263_19887448_ChIP-Seq_K562_Human1.16484708
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16048065
69TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15450859
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14040617
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.12729169
72CJUN_26792858_Chip-Seq_BT549_Human1.12451783
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12439723
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12311023
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.11955887
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10806374
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10284322
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09957403
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09957403
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09511850
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08673034
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07205067
83* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07170845
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06445108
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06238589
86GATA1_22025678_ChIP-Seq_K562_Human1.06167924
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06026571
88TCF7_22412390_ChIP-Seq_EML_Mouse1.04655509
89* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02681322
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02315175
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00966048
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00919396
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00425043
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99573524
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99071960
96* RUNX1_27514584_Chip-Seq_MCF-7_Human0.98524466
97KDM2B_26808549_Chip-Seq_DND41_Human0.98053324
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98007656
99SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97914707
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97139552
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97011384
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96841333
103STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96762190
104SMC4_20622854_ChIP-Seq_HELA_Human0.96699585
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95572237
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95465322
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95451248
108* IRF8_27001747_Chip-Seq_BMDM_Mouse0.94384643
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93715130
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93452405
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93162368
112MYC_22102868_ChIP-Seq_BL_Human0.92898480
113VDR_21846776_ChIP-Seq_THP-1_Human0.92475597
114CREB1_26743006_Chip-Seq_LNCaP_Human0.92347046
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92304184
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92178973
117NCOR1_26117541_ChIP-Seq_K562_Human0.92027655
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91915061
119GATA1_19941826_ChIP-Seq_K562_Human0.91444083
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91295360
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.90756648
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90572260
123BRD4_25478319_ChIP-Seq_HGPS_Human0.90269035
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90263583
125* TP53_23651856_ChIP-Seq_MEFs_Mouse0.89791410
126* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89008263
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.88665918
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88163204
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87943174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.12555285
2MP0003705_abnormal_hypodermis_morpholog3.99574168
3MP0005360_urolithiasis3.88763379
4MP0002139_abnormal_hepatobiliary_system3.72651465
5MP0005365_abnormal_bile_salt3.16763758
6MP0005085_abnormal_gallbladder_physiolo3.03298233
7MP0003252_abnormal_bile_duct2.80315631
8MP0001666_abnormal_nutrient_absorption2.45027999
9MP0005275_abnormal_skin_tensile2.42178556
10MP0009840_abnormal_foam_cell2.33753840
11MP0005083_abnormal_biliary_tract2.24933220
12MP0010234_abnormal_vibrissa_follicle2.19289340
13MP0005409_darkened_coat_color2.01790582
14MP0003300_gastrointestinal_ulcer1.94378732
15MP0008875_abnormal_xenobiotic_pharmacok1.92852731
16MP0003566_abnormal_cell_adhesion1.92260384
17MP0004272_abnormal_basement_membrane1.89970344
18MP0003191_abnormal_cellular_cholesterol1.88842285
19MP0010329_abnormal_lipoprotein_level1.88149612
20MP0005451_abnormal_body_composition1.85427244
21MP0010352_gastrointestinal_tract_polyps1.72829012
22MP0005503_abnormal_tendon_morphology1.69228453
23MP0003950_abnormal_plasma_membrane1.61229632
24MP0004858_abnormal_nervous_system1.61187430
25MP0002089_abnormal_postnatal_growth/wei1.60676676
26MP0003806_abnormal_nucleotide_metabolis1.59642596
27MP0003279_aneurysm1.58093972
28MP0005257_abnormal_intraocular_pressure1.54829843
29MP0005023_abnormal_wound_healing1.53746694
30MP0004264_abnormal_extraembryonic_tissu1.53145846
31MP0005058_abnormal_lysosome_morphology1.52585466
32MP0009384_cardiac_valve_regurgitation1.51269789
33MP0005076_abnormal_cell_differentiation1.46351935
34MP0003941_abnormal_skin_development1.46312559
35MP0006054_spinal_hemorrhage1.45522160
36MP0002060_abnormal_skin_morphology1.45314028
37MP0003283_abnormal_digestive_organ1.41601694
38MP0004185_abnormal_adipocyte_glucose1.41366191
39MP0003868_abnormal_feces_composition1.40112388
40MP0000609_abnormal_liver_physiology1.33384097
41MP0003195_calcinosis1.29097720
42MP0005670_abnormal_white_adipose1.26871226
43MP0005220_abnormal_exocrine_pancreas1.26239361
44MP0003172_abnormal_lysosome_physiology1.23946376
45MP0009053_abnormal_anal_canal1.22925898
46MP0002896_abnormal_bone_mineralization1.20895383
47MP0010368_abnormal_lymphatic_system1.20639890
48MP0002118_abnormal_lipid_homeostasis1.20136672
49MP0003045_fibrosis1.19533780
50MP0000858_altered_metastatic_potential1.19025275
51MP0000566_synostosis1.18900456
52MP0001958_emphysema1.18685267
53MP0005666_abnormal_adipose_tissue1.17902089
54MP0005332_abnormal_amino_acid1.13650737
55MP0000751_myopathy1.11152391
56MP0002877_abnormal_melanocyte_morpholog1.10126370
57MP0000762_abnormal_tongue_morphology1.08928388
58MP0009643_abnormal_urine_homeostasis1.07929448
59MP0005319_abnormal_enzyme/_coenzyme1.07491349
60MP0010030_abnormal_orbit_morphology1.04825475
61MP0002138_abnormal_hepatobiliary_system1.04089573
62MP0005408_hypopigmentation1.02395775
63MP0005375_adipose_tissue_phenotype1.01688167
64MP0003329_amyloid_beta_deposits0.99716315
65MP0005164_abnormal_response_to0.99537462
66MP0001243_abnormal_dermal_layer0.95998878
67MP0004019_abnormal_vitamin_homeostasis0.95120829
68MP0003453_abnormal_keratinocyte_physiol0.94991571
69MP0001849_ear_inflammation0.94983309
70MP0000003_abnormal_adipose_tissue0.93772520
71MP0002168_other_aberrant_phenotype0.93604530
72MP0003091_abnormal_cell_migration0.92274151
73MP0000598_abnormal_liver_morphology0.92113741
74MP0002295_abnormal_pulmonary_circulatio0.90344032
75MP0001533_abnormal_skeleton_physiology0.89875726
76MP0000467_abnormal_esophagus_morphology0.89511843
77MP0000678_abnormal_parathyroid_gland0.89434416
78MP0000767_abnormal_smooth_muscle0.88816426
79MP0000534_abnormal_ureter_morphology0.88006288
80MP0005508_abnormal_skeleton_morphology0.86260198
81MP0003303_peritoneal_inflammation0.84994283
82MP0008260_abnormal_autophagy0.82987624
83MP0004947_skin_inflammation0.80669057
84MP0002254_reproductive_system_inflammat0.79216639
85MP0005623_abnormal_meninges_morphology0.79099872
86MP0004782_abnormal_surfactant_physiolog0.78993810
87MP0000462_abnormal_digestive_system0.77998900
88MP0001348_abnormal_lacrimal_gland0.77938902
89MP0001216_abnormal_epidermal_layer0.77288827
90MP0001299_abnormal_eye_distance/0.75687080
91MP0001614_abnormal_blood_vessel0.75601579
92MP0001661_extended_life_span0.75313313
93MP0001542_abnormal_bone_strength0.75203243
94MP0002108_abnormal_muscle_morphology0.74990587
95MP0009780_abnormal_chondrocyte_physiolo0.73906158
96MP0009278_abnormal_bone_marrow0.73499178
97MP0003385_abnormal_body_wall0.73435358
98MP0000733_abnormal_muscle_development0.72807374
99MP0003436_decreased_susceptibility_to0.72765750
100MP0005390_skeleton_phenotype0.72646275
101MP0002928_abnormal_bile_duct0.71665512
102MP0001915_intracranial_hemorrhage0.70647512
103MP0003183_abnormal_peptide_metabolism0.70361654
104MP0000537_abnormal_urethra_morphology0.69992164
105MP0002998_abnormal_bone_remodeling0.69288734
106MP0005621_abnormal_cell_physiology0.68908138
107MP0003942_abnormal_urinary_system0.68311770
108MP0005165_increased_susceptibility_to0.67847240
109MP0002933_joint_inflammation0.67786941
110MP0002796_impaired_skin_barrier0.67732329
111MP0005501_abnormal_skin_physiology0.67603454
112MP0006138_congestive_heart_failure0.66835886
113MP0005595_abnormal_vascular_smooth0.66447675
114MP0000163_abnormal_cartilage_morphology0.66413458
115MP0003795_abnormal_bone_structure0.65321272
116MP0000013_abnormal_adipose_tissue0.64672533
117MP0002115_abnormal_skeleton_extremities0.64429711
118MP0005197_abnormal_uvea_morphology0.63996789
119MP0004233_abnormal_muscle_weight0.63961493
120MP0002925_abnormal_cardiovascular_devel0.63507322
121MP0001756_abnormal_urination0.61302460
122MP0002128_abnormal_blood_circulation0.60954687
123MP0004130_abnormal_muscle_cell0.60677619
124MP0000477_abnormal_intestine_morphology0.60482865
125MP0003115_abnormal_respiratory_system0.60152591
126MP0010678_abnormal_skin_adnexa0.57572207
127MP0010307_abnormal_tumor_latency0.56503770
128MP0000249_abnormal_blood_vessel0.55654998
129MP0008469_abnormal_protein_level0.55012332
130MP0002136_abnormal_kidney_physiology0.54645698
131MP0009763_increased_sensitivity_to0.54643093
132MP0001881_abnormal_mammary_gland0.54159002
133MP0005084_abnormal_gallbladder_morpholo0.54081016
134MP0010630_abnormal_cardiac_muscle0.53755123
135MP0001944_abnormal_pancreas_morphology0.53647773
136MP0000604_amyloidosis0.53481935
137MP0004197_abnormal_fetal_growth/weight/0.52540351
138MP0005334_abnormal_fat_pad0.52537539
139MP0010155_abnormal_intestine_physiology0.52472798

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.52706700
2Premature rupture of membranes (HP:0001788)4.28256285
3Deep venous thrombosis (HP:0002625)4.07806827
4Xanthomatosis (HP:0000991)3.59497530
5Intrahepatic cholestasis (HP:0001406)3.57845781
6Cerebral aneurysm (HP:0004944)3.46811573
7Complement deficiency (HP:0004431)3.36116360
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35116456
9Vascular tortuosity (HP:0004948)3.18897319
10Peritonitis (HP:0002586)3.17267892
11Arterial tortuosity (HP:0005116)3.14710590
12Myocardial infarction (HP:0001658)3.05365376
13Aortic dissection (HP:0002647)2.99127877
14Abnormality of the common coagulation pathway (HP:0010990)2.95955514
15Cervical subluxation (HP:0003308)2.95537026
16Atrophic scars (HP:0001075)2.91869180
17Shallow orbits (HP:0000586)2.88613131
18Right ventricular cardiomyopathy (HP:0011663)2.77085136
19Ankle contracture (HP:0006466)2.76925494
20Abnormality of glutamine family amino acid metabolism (HP:0010902)2.74499020
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73434456
22Abnormality of complement system (HP:0005339)2.73328791
23Mitral valve prolapse (HP:0001634)2.73307331
24Hypoglycemic coma (HP:0001325)2.72832455
25Abnormality of the intrinsic pathway (HP:0010989)2.72765805
26Abnormality of carpal bone ossification (HP:0006257)2.67291422
27Abnormality of dentin (HP:0010299)2.66115677
28Flat acetabular roof (HP:0003180)2.57234537
29Aortic aneurysm (HP:0004942)2.57135054
30Aneurysm (HP:0002617)2.55927288
31Hypoalphalipoproteinemia (HP:0003233)2.54874339
32Systemic lupus erythematosus (HP:0002725)2.51525374
33Hypobetalipoproteinemia (HP:0003563)2.48379877
34Broad metatarsal (HP:0001783)2.48164986
35Abnormal ossification of hand bones (HP:0005921)2.40991497
36Blue sclerae (HP:0000592)2.40657965
37Hypolipoproteinemia (HP:0010981)2.40528542
38Fat malabsorption (HP:0002630)2.38246534
39Increased connective tissue (HP:0009025)2.38031763
40Short nail (HP:0001799)2.32175204
41Prolonged partial thromboplastin time (HP:0003645)2.31997569
42Abnormality of the Achilles tendon (HP:0005109)2.31823820
43Epidermoid cyst (HP:0200040)2.30990458
44Fragile skin (HP:0001030)2.30653901
45Esophageal varix (HP:0002040)2.30032811
46Broad face (HP:0000283)2.29657287
47Follicular hyperkeratosis (HP:0007502)2.29320193
48Skin nodule (HP:0200036)2.26306909
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.23565089
50Hyperlipoproteinemia (HP:0010980)2.22586764
51Cupped ribs (HP:0000887)2.21867164
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21384910
53Hydroxyprolinuria (HP:0003080)2.21250625
54Abnormality of proline metabolism (HP:0010907)2.21250625
55Natal tooth (HP:0000695)2.20604254
56Hyperacusis (HP:0010780)2.19212690
57Asymmetry of the thorax (HP:0001555)2.17130599
58Achilles tendon contracture (HP:0001771)2.17120631
59Ulnar bowing (HP:0003031)2.13996147
60Bladder diverticulum (HP:0000015)2.13389086
61Soft skin (HP:0000977)2.13304932
62Glomerulonephritis (HP:0000099)2.12733232
63Disproportionate tall stature (HP:0001519)2.11459797
64Dilatation of the ascending aorta (HP:0005111)2.11231063
65Coxa vara (HP:0002812)2.11099646
66Ectopia lentis (HP:0001083)2.10263424
67Abnormal cartilage morphology (HP:0002763)2.09144108
68Elbow flexion contracture (HP:0002987)2.08187708
69Urinary glycosaminoglycan excretion (HP:0003541)2.07527328
70Mucopolysacchariduria (HP:0008155)2.07527328
71Cardiovascular calcification (HP:0011915)2.07215338
72Hypoplastic ischia (HP:0003175)2.05589385
73Advanced eruption of teeth (HP:0006288)2.05530352
74Joint laxity (HP:0001388)2.04147324
75Turricephaly (HP:0000262)2.03254248
76Neonatal short-limb short stature (HP:0008921)2.03249733
77Thin bony cortex (HP:0002753)2.02763275
78Osteolytic defects of the hand bones (HP:0009699)2.02524797
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.02524797
80Protuberant abdomen (HP:0001538)2.02364124
81Joint hemorrhage (HP:0005261)2.02005710
82Abdominal distention (HP:0003270)2.01871547
83Genu recurvatum (HP:0002816)2.01416561
84Menorrhagia (HP:0000132)2.01383198
85Mildly elevated creatine phosphokinase (HP:0008180)1.99238392
86Distal lower limb amyotrophy (HP:0008944)1.98785352
87Hypercholesterolemia (HP:0003124)1.98403957
88Abnormal hand bone ossification (HP:0010660)1.97817208
89Small epiphyses (HP:0010585)1.97053957
90Abnormality of the ischium (HP:0003174)1.96739692
91Mitral regurgitation (HP:0001653)1.96259599
92Nephritis (HP:0000123)1.96196573
93Mitral stenosis (HP:0001718)1.95721097
94Abnormality of the acetabulum (HP:0003170)1.94928867
95Hemorrhage of the eye (HP:0011885)1.94636426
96Spondylolisthesis (HP:0003302)1.94606016
97Alopecia of scalp (HP:0002293)1.93731168
98Nonimmune hydrops fetalis (HP:0001790)1.91255520
99Abnormal tarsal ossification (HP:0008369)1.90749195
100Abnormal foot bone ossification (HP:0010675)1.90534385
101Dysostosis multiplex (HP:0000943)1.89990309
102Abnormal delivery (HP:0001787)1.88362452
103Ketosis (HP:0001946)1.88359217
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87536264
105Abnormality of polysaccharide metabolism (HP:0011012)1.87536264
106Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87536264
107Bronchomalacia (HP:0002780)1.87018256
108Hyperglycemia (HP:0003074)1.84377295
109Biconcave vertebral bodies (HP:0004586)1.83024479
110Neonatal death (HP:0003811)1.82852190
111Hypoglycemic seizures (HP:0002173)1.81771501
112Aortic regurgitation (HP:0001659)1.81383798
113Wormian bones (HP:0002645)1.80686318
114Back pain (HP:0003418)1.80505803
115Tibial bowing (HP:0002982)1.79037568
116Vertebral compression fractures (HP:0002953)1.78967507
117Lymphangioma (HP:0100764)1.78316844
118Spinal rigidity (HP:0003306)1.78067554
119Hyperammonemia (HP:0001987)1.77594227
120Hematochezia (HP:0002573)1.77141162
121Distal upper limb amyotrophy (HP:0007149)1.77013503
122Upper limb amyotrophy (HP:0009129)1.77013503
123Malnutrition (HP:0004395)1.76796143
124Type 1 muscle fiber predominance (HP:0003803)1.76263128
125Hyperextensible skin (HP:0000974)1.75751641
126Abnormality of purine metabolism (HP:0004352)1.73671758
127Renal duplication (HP:0000075)1.73650463
128Vascular calcification (HP:0004934)1.73437761
129Osteoarthritis (HP:0002758)1.69897462
130Flared iliac wings (HP:0002869)1.68521177
131Premature skin wrinkling (HP:0100678)1.67170255
132Increased variability in muscle fiber diameter (HP:0003557)1.66698125
133Epiphyseal dysplasia (HP:0002656)1.65408882
134Ovoid vertebral bodies (HP:0003300)1.64641920
135Joint stiffness (HP:0001387)1.63140945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.37062517
2TRIB33.86345171
3PKN22.98317624
4SIK12.92439541
5LATS12.56682088
6RIPK12.45590772
7MST1R2.29866201
8TAOK32.29043746
9PTK62.25777397
10SMG12.23863475
11FRK2.22235702
12DDR22.20070660
13TTN2.04353824
14PDGFRA2.01291457
15PIK3CA1.90425252
16EPHB11.84430589
17CDK121.80460656
18CAMK1D1.78296600
19FGFR41.78033800
20MET1.75771276
21TGFBR21.63937659
22MYLK1.63787073
23BCKDK1.61809873
24MAP3K101.61525868
25NTRK11.48682663
26PTK21.46370575
27MAP2K21.43077516
28EEF2K1.32784386
29CAMK1G1.32158564
30TESK11.32070971
31EPHA21.31632472
32AKT31.30776224
33PAK21.27831392
34PRPF4B1.25522845
35BMX1.23715577
36MTOR1.22364677
37FLT31.19161486
38INSRR1.18415334
39MAP3K31.14829152
40PAK41.12917451
41EPHA31.11417976
42STK31.10296254
43STK101.06314654
44LRRK21.04916284
45JAK11.01756719
46ICK1.01461437
47EPHB20.98673183
48PDGFRB0.96937632
49PRKD20.96272226
50STK380.91217293
51MAPKAPK30.90524258
52TYK20.88847321
53TBK10.88501073
54CDK60.87896853
55MAP3K20.87432397
56MAP2K30.87219191
57CSK0.84526528
58FER0.84512057
59DMPK0.84316125
60MAP3K60.83951914
61RPS6KA20.83125936
62NEK90.82132131
63IRAK30.79090752
64TRPM70.73981546
65NUAK10.69522125
66WNK10.69055228
67MARK20.68938655
68NME20.68579045
69PIK3CG0.67483344
70MAPK150.67149090
71ERBB40.66207134
72MAP3K80.66035948
73PRKG20.65790068
74LATS20.64294200
75SCYL20.64038904
76GSK3A0.63501629
77JAK20.62615681
78KDR0.62088831
79TAOK20.61774696
80TYRO30.61772861
81CSF1R0.61029596
82FGFR30.60711986
83MAP3K70.59782745
84RET0.58661625
85DYRK1B0.58349073
86MAP2K10.57576036
87CHUK0.56848710
88PRKAA20.56614128
89MAPK110.56307466
90MELK0.55340080
91ERBB20.54567243
92FGFR10.52690937
93STK38L0.52363494
94RPS6KA40.51192473
95LMTK20.50568735
96PRKD10.50215648
97PIM20.48241039
98CDK70.47647828
99MAP3K10.47514525
100WNK40.45444415
101ZAP700.44946156
102KSR20.44391369
103TAOK10.44107553
104JAK30.43677170
105LIMK10.43494503
106MAP3K130.42760519
107RPS6KB20.42224397
108PAK30.40401951
109EGFR0.39301577
110RPS6KC10.37931737
111RPS6KL10.37931737
112INSR0.37479089
113MAPKAPK20.37093932
114CDK40.37004506
115FGFR20.36976415
116KIT0.36035075
117CDC42BPA0.35305563
118ARAF0.35212156
119IGF1R0.34993586
120ROCK20.34874457
121CDK90.34290660
122MOS0.33933124
123MAP3K140.33012295
124HIPK20.32768937
125PRKCH0.32157618
126SRC0.32060853
127PDPK10.31701802
128ABL20.31118808
129ABL10.30161853
130SGK30.29918398
131ROCK10.29333322
132ILK0.29285505

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.77123105
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74213742
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.67493117
4Fat digestion and absorption_Homo sapiens_hsa049752.40643882
5Complement and coagulation cascades_Homo sapiens_hsa046102.37131026
6Arginine biosynthesis_Homo sapiens_hsa002202.19803057
7Tryptophan metabolism_Homo sapiens_hsa003802.11714125
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.03288432
9Fatty acid degradation_Homo sapiens_hsa000712.00596265
10Staphylococcus aureus infection_Homo sapiens_hsa051501.99825616
11Caffeine metabolism_Homo sapiens_hsa002321.98611752
12Sulfur metabolism_Homo sapiens_hsa009201.93629445
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93147376
14PPAR signaling pathway_Homo sapiens_hsa033201.82068447
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.78746939
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72951393
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70142132
18Protein digestion and absorption_Homo sapiens_hsa049741.63265272
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57618691
20Bile secretion_Homo sapiens_hsa049761.55231015
21Selenocompound metabolism_Homo sapiens_hsa004501.52757491
22Starch and sucrose metabolism_Homo sapiens_hsa005001.51588370
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49515992
24ECM-receptor interaction_Homo sapiens_hsa045121.48935420
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48668302
26Lysine degradation_Homo sapiens_hsa003101.38865814
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38785945
28Fatty acid metabolism_Homo sapiens_hsa012121.36586637
29Histidine metabolism_Homo sapiens_hsa003401.36377183
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28954575
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.22762450
32Chemical carcinogenesis_Homo sapiens_hsa052041.22682109
33* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20539782
34Propanoate metabolism_Homo sapiens_hsa006401.17733469
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16527502
36Thyroid hormone synthesis_Homo sapiens_hsa049181.15850266
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13770881
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10871474
39Vitamin digestion and absorption_Homo sapiens_hsa049771.06972933
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.05781104
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04087322
42Peroxisome_Homo sapiens_hsa041461.03548929
43ABC transporters_Homo sapiens_hsa020101.02834814
44Folate biosynthesis_Homo sapiens_hsa007901.02619545
45Butanoate metabolism_Homo sapiens_hsa006501.02258144
46beta-Alanine metabolism_Homo sapiens_hsa004101.00232609
47Notch signaling pathway_Homo sapiens_hsa043300.99836150
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97688740
49Amoebiasis_Homo sapiens_hsa051460.95824867
50Focal adhesion_Homo sapiens_hsa045100.95771508
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.95149556
52Thyroid cancer_Homo sapiens_hsa052160.95006061
53Renin-angiotensin system_Homo sapiens_hsa046140.91989334
54Insulin resistance_Homo sapiens_hsa049310.90613983
55Adherens junction_Homo sapiens_hsa045200.90220578
56Bladder cancer_Homo sapiens_hsa052190.87573515
57Arginine and proline metabolism_Homo sapiens_hsa003300.86909149
58Retinol metabolism_Homo sapiens_hsa008300.86797481
59Phenylalanine metabolism_Homo sapiens_hsa003600.86541810
60Glycerolipid metabolism_Homo sapiens_hsa005610.86080455
61Galactose metabolism_Homo sapiens_hsa000520.85366102
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84289393
63Steroid biosynthesis_Homo sapiens_hsa001000.82544361
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77848338
65Carbon metabolism_Homo sapiens_hsa012000.76936976
66Pertussis_Homo sapiens_hsa051330.76523110
67Other glycan degradation_Homo sapiens_hsa005110.76413859
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76256844
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75839218
70Lysosome_Homo sapiens_hsa041420.75764111
71Pyruvate metabolism_Homo sapiens_hsa006200.75203229
72Small cell lung cancer_Homo sapiens_hsa052220.74998300
73Tyrosine metabolism_Homo sapiens_hsa003500.73440729
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72822012
75Proteoglycans in cancer_Homo sapiens_hsa052050.70567368
76Acute myeloid leukemia_Homo sapiens_hsa052210.70157284
77Tight junction_Homo sapiens_hsa045300.70116226
78Non-small cell lung cancer_Homo sapiens_hsa052230.69582278
79Sphingolipid metabolism_Homo sapiens_hsa006000.68636840
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67923233
81Endometrial cancer_Homo sapiens_hsa052130.67580078
82Biosynthesis of amino acids_Homo sapiens_hsa012300.67416726
83Vibrio cholerae infection_Homo sapiens_hsa051100.66665775
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65690589
85Insulin signaling pathway_Homo sapiens_hsa049100.64448620
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63818908
87Sulfur relay system_Homo sapiens_hsa041220.62817772
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62800554
89Dilated cardiomyopathy_Homo sapiens_hsa054140.62689962
90VEGF signaling pathway_Homo sapiens_hsa043700.62472280
91Chronic myeloid leukemia_Homo sapiens_hsa052200.61986700
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.59421649
93Hepatitis C_Homo sapiens_hsa051600.57967411
94One carbon pool by folate_Homo sapiens_hsa006700.57204273
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57194593
96Renal cell carcinoma_Homo sapiens_hsa052110.56062083
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55387267
98Prion diseases_Homo sapiens_hsa050200.54847845
99TNF signaling pathway_Homo sapiens_hsa046680.54169104
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53482013
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.53222243
102Mineral absorption_Homo sapiens_hsa049780.52531353
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52517655
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51614909
105Glioma_Homo sapiens_hsa052140.51497297
106Toxoplasmosis_Homo sapiens_hsa051450.51453921
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51168281
108Hippo signaling pathway_Homo sapiens_hsa043900.50822052
109Pathways in cancer_Homo sapiens_hsa052000.49625575
110Pancreatic secretion_Homo sapiens_hsa049720.48541881
111mTOR signaling pathway_Homo sapiens_hsa041500.48355752
112Glucagon signaling pathway_Homo sapiens_hsa049220.48250764
113Malaria_Homo sapiens_hsa051440.48007845
114HIF-1 signaling pathway_Homo sapiens_hsa040660.47303262
115Vitamin B6 metabolism_Homo sapiens_hsa007500.46815949
116Glutathione metabolism_Homo sapiens_hsa004800.46613580
117ErbB signaling pathway_Homo sapiens_hsa040120.46288218
118Fatty acid biosynthesis_Homo sapiens_hsa000610.44484173
119Fructose and mannose metabolism_Homo sapiens_hsa000510.43468910
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.42031582
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.42020244
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41550868
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40382729
124Prostate cancer_Homo sapiens_hsa052150.39968322
125AMPK signaling pathway_Homo sapiens_hsa041520.39444758
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39438421
127N-Glycan biosynthesis_Homo sapiens_hsa005100.38266578
128Pentose phosphate pathway_Homo sapiens_hsa000300.37576767
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37157392
130Linoleic acid metabolism_Homo sapiens_hsa005910.36735476
131TGF-beta signaling pathway_Homo sapiens_hsa043500.34570021
132Leishmaniasis_Homo sapiens_hsa051400.33291622
133Pancreatic cancer_Homo sapiens_hsa052120.33204737
134MicroRNAs in cancer_Homo sapiens_hsa052060.33008731

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »