RREB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)4.53001968
2modulation by symbiont of host defense response (GO:0052031)3.90469627
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.90469627
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.90469627
5positive regulation by organism of defense response of other organism involved in symbiotic interact3.90469627
6modulation by symbiont of host immune response (GO:0052553)3.90469627
7positive regulation by symbiont of host defense response (GO:0052509)3.90469627
8phospholipid homeostasis (GO:0055091)3.87864296
9negative regulation of erythrocyte differentiation (GO:0045647)3.70255857
10interkinetic nuclear migration (GO:0022027)3.64717009
11mannose metabolic process (GO:0006013)3.40654229
12negative regulation of granulocyte differentiation (GO:0030853)3.37899240
13regulation of interferon-beta biosynthetic process (GO:0045357)3.33622976
14regulation of cholesterol storage (GO:0010885)3.31353732
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.30164521
16regulation of sequestering of triglyceride (GO:0010889)3.29927428
17histone H3-K36 demethylation (GO:0070544)3.28922183
18cellular response to ethanol (GO:0071361)3.28492280
19macrophage activation involved in immune response (GO:0002281)3.28459562
20positive regulation of histone deacetylation (GO:0031065)3.24867755
21positive regulation of gamma-delta T cell activation (GO:0046645)3.24141069
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.23274750
23carnitine shuttle (GO:0006853)3.20938372
242-oxoglutarate metabolic process (GO:0006103)3.19123741
25fatty acid transmembrane transport (GO:1902001)3.18168044
26regulation of cholesterol homeostasis (GO:2000188)3.16626293
27cellular response to exogenous dsRNA (GO:0071360)3.12791121
28alpha-linolenic acid metabolic process (GO:0036109)3.12684566
29valine metabolic process (GO:0006573)3.12201736
30desmosome organization (GO:0002934)3.11901806
31urea metabolic process (GO:0019627)3.09254022
32urea cycle (GO:0000050)3.09254022
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09182796
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07783909
35regulation of gamma-delta T cell differentiation (GO:0045586)2.98784548
36positive regulation of B cell differentiation (GO:0045579)2.95820822
37positive regulation of granulocyte differentiation (GO:0030854)2.95524941
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.94570131
39embryonic process involved in female pregnancy (GO:0060136)2.92910176
40positive regulation of fatty acid beta-oxidation (GO:0032000)2.91457587
41regulation of gamma-delta T cell activation (GO:0046643)2.84730700
42regulation of triglyceride catabolic process (GO:0010896)2.83824774
43positive regulation of p38MAPK cascade (GO:1900745)2.82601845
44lysine metabolic process (GO:0006553)2.81993949
45lysine catabolic process (GO:0006554)2.81993949
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81798231
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81798231
48negative regulation of stress fiber assembly (GO:0051497)2.81449556
49complement activation, alternative pathway (GO:0006957)2.80856609
50dicarboxylic acid biosynthetic process (GO:0043650)2.79491471
51positive regulation of lipid catabolic process (GO:0050996)2.77147611
52regulation of fatty acid beta-oxidation (GO:0031998)2.74942812
53histone H3-K4 trimethylation (GO:0080182)2.74931463
54biotin metabolic process (GO:0006768)2.70540247
55positive regulation of protein deacetylation (GO:0090312)2.69474768
56positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68463302
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68166078
58positive regulation of triglyceride biosynthetic process (GO:0010867)2.67178731
59positive regulation of triglyceride metabolic process (GO:0090208)2.67126282
60homocysteine metabolic process (GO:0050667)2.66845568
61apoptotic cell clearance (GO:0043277)2.62408838
62embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61911881
63nitrogen cycle metabolic process (GO:0071941)2.61689783
64amino-acid betaine metabolic process (GO:0006577)2.60931315
65antigen processing and presentation via MHC class Ib (GO:0002475)2.59697278
66peptidyl-glutamic acid carboxylation (GO:0017187)2.58714508
67protein carboxylation (GO:0018214)2.58714508
68serine family amino acid catabolic process (GO:0009071)2.58191078
69low-density lipoprotein particle clearance (GO:0034383)2.58151925
70phospholipid efflux (GO:0033700)2.58012728
71carnitine transmembrane transport (GO:1902603)2.56667605
72regulation of triglyceride biosynthetic process (GO:0010866)2.54745372
73lipoprotein transport (GO:0042953)2.54082875
74regulation of histone H3-K27 methylation (GO:0061085)2.50504338
75cytoplasmic mRNA processing body assembly (GO:0033962)2.50013851
76cellular extravasation (GO:0045123)2.49943349
77pre-miRNA processing (GO:0031054)2.49734339
78regulation of p38MAPK cascade (GO:1900744)2.45536417
79regulation of establishment of cell polarity (GO:2000114)2.44375616
80hepatocyte apoptotic process (GO:0097284)2.44274849
81regulation of granulocyte differentiation (GO:0030852)2.44206457
82regulation of protein activation cascade (GO:2000257)2.44007066
83regulation of triglyceride metabolic process (GO:0090207)2.43381153
84response to muramyl dipeptide (GO:0032495)2.43187042
85positive regulation of fatty acid oxidation (GO:0046321)2.43013578
86establishment of skin barrier (GO:0061436)2.42344395
87monoubiquitinated protein deubiquitination (GO:0035520)2.42309320
88response to host defenses (GO:0052200)2.42011212
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42011212
90response to host (GO:0075136)2.42011212
91negative regulation of actin filament bundle assembly (GO:0032232)2.41854366
92carnitine transport (GO:0015879)2.41394617
93amino-acid betaine transport (GO:0015838)2.41394617
94fatty acid beta-oxidation (GO:0006635)2.41329214
95detection of molecule of bacterial origin (GO:0032490)2.41144426
96regulation of fatty acid oxidation (GO:0046320)2.40492020
97plasma lipoprotein particle clearance (GO:0034381)2.40296232
98plasma lipoprotein particle assembly (GO:0034377)2.39048131
99antigen processing and presentation of endogenous antigen (GO:0019883)2.39035194
100regulation of establishment or maintenance of cell polarity (GO:0032878)2.38574336
101positive regulation of cholesterol efflux (GO:0010875)2.38405597
102response to host immune response (GO:0052572)2.37963503
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37963503
104positive regulation of cholesterol transport (GO:0032376)2.37755122
105positive regulation of sterol transport (GO:0032373)2.37755122
106histone H3-K4 methylation (GO:0051568)2.37195950
107pinocytosis (GO:0006907)2.36708272
108regulation of complement activation (GO:0030449)2.36593934
109positive regulation of lipid storage (GO:0010884)2.36111974
110B cell receptor signaling pathway (GO:0050853)2.35601049
111I-kappaB phosphorylation (GO:0007252)2.35510515
112positive regulation of chemokine secretion (GO:0090197)2.34977658
113protein-lipid complex assembly (GO:0065005)2.34672575
114glucocorticoid receptor signaling pathway (GO:0042921)2.33568619
115negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.33046578
116intestinal epithelial cell development (GO:0060576)2.32108920
117striated muscle atrophy (GO:0014891)2.31813640
118negative regulation of phagocytosis (GO:0050765)2.31565638
119NLS-bearing protein import into nucleus (GO:0006607)2.31069889
120regulation of water loss via skin (GO:0033561)2.31035884
121kynurenine metabolic process (GO:0070189)2.30757441
122iron ion import (GO:0097286)2.30477937
123acylglycerol homeostasis (GO:0055090)2.30446085
124triglyceride homeostasis (GO:0070328)2.30446085
125cysteine metabolic process (GO:0006534)2.30131246
126cell-substrate junction assembly (GO:0007044)2.30093447
127sulfur amino acid catabolic process (GO:0000098)2.29808006
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.28483214
129phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.28427210
130negative regulation of fatty acid transport (GO:2000192)2.27090609
131flavonoid metabolic process (GO:0009812)2.26175884
132regulation of integrin activation (GO:0033623)2.25331443
133peptidyl-lysine trimethylation (GO:0018023)2.24935325
134growth hormone receptor signaling pathway (GO:0060396)2.24391925
135embryonic hemopoiesis (GO:0035162)2.23452992
136insulin-like growth factor receptor signaling pathway (GO:0048009)2.21897986
137peptidyl-lysine methylation (GO:0018022)2.20807485
138early endosome to late endosome transport (GO:0045022)2.20633315
139detection of other organism (GO:0098543)2.19232999
140negative regulation of interleukin-8 production (GO:0032717)2.19044554
141detection of bacterium (GO:0016045)2.18767140
142TOR signaling (GO:0031929)2.17457970
143germinal center formation (GO:0002467)2.17327313
144regulation of B cell receptor signaling pathway (GO:0050855)2.16209132
145megakaryocyte development (GO:0035855)2.15272730
146positive thymic T cell selection (GO:0045059)2.14845839
147histone lysine demethylation (GO:0070076)2.14020901
148response to peptidoglycan (GO:0032494)2.12926775
149corticosteroid receptor signaling pathway (GO:0031958)2.12381664
150cellular response to growth hormone stimulus (GO:0071378)2.12309836
151positive regulation of protein import into nucleus, translocation (GO:0033160)2.11548481
152positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.11491828
153histone lysine methylation (GO:0034968)2.11378465
154phospholipid translocation (GO:0045332)2.11347128
155lipid translocation (GO:0034204)2.11347128
156negative regulation of protein activation cascade (GO:2000258)2.11123633
157negative regulation of fibrinolysis (GO:0051918)2.10289499
158white fat cell differentiation (GO:0050872)2.09976588
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.09883865
160histone demethylation (GO:0016577)2.09075845
161positive regulation of DNA-templated transcription, initiation (GO:2000144)2.07517834
162regulation of germinal center formation (GO:0002634)2.06319162
163JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.05449680
164detection of external biotic stimulus (GO:0098581)2.05233368
165negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.04964124
166negative regulation of T-helper cell differentiation (GO:0045623)2.04964124
167negative regulation of complement activation (GO:0045916)2.04643007
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.04327743
169positive regulation of mRNA catabolic process (GO:0061014)2.04291878
170trophectodermal cell differentiation (GO:0001829)2.04176649
171regulation of B cell differentiation (GO:0045577)2.03902760
172regulation of chemokine secretion (GO:0090196)2.03838343
173protein K48-linked deubiquitination (GO:0071108)2.01992783
174negative regulation of TOR signaling (GO:0032007)2.01514310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.13532114
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.25544481
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.21225828
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.17857609
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12982213
6GATA1_22025678_ChIP-Seq_K562_Human3.04965262
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.03747848
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88782771
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.87912173
10* SCL_19346495_ChIP-Seq_HPC-7_Human2.70859479
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59003134
12MYC_22102868_ChIP-Seq_BL_Human2.48465076
13* IRF8_22096565_ChIP-ChIP_GC-B_Human2.48420097
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.35735694
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26023415
16VDR_21846776_ChIP-Seq_THP-1_Human2.20283955
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11418588
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02227809
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01113275
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98980625
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97058363
22SPI1_23127762_ChIP-Seq_K562_Human1.94520939
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94145518
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89347073
25* IRF8_27001747_Chip-Seq_BMDM_Mouse1.86920193
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86696503
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79221577
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78124412
29KDM2B_26808549_Chip-Seq_DND41_Human1.77911877
30* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77834045
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.76504525
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.75643183
33* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73313713
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.73070297
35* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72387210
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71810679
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71614586
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67826432
39* GATA1_19941827_ChIP-Seq_MEL_Mouse1.67795230
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64319821
41VDR_24763502_ChIP-Seq_THP-1_Human1.63932539
42* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62850592
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62253147
44AHR_22903824_ChIP-Seq_MCF-7_Human1.62157295
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.58452461
46MAF_26560356_Chip-Seq_TH1_Human1.55810538
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55070270
48GATA1_19941826_ChIP-Seq_K562_Human1.53833698
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.51559588
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49312832
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49126713
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.48858517
53RUNX_20019798_ChIP-Seq_JUKART_Human1.48306182
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.45819893
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44634299
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43088919
57UTX_26944678_Chip-Seq_JUKART_Human1.43063270
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.42794550
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41808553
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41789377
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41485992
62LXR_22292898_ChIP-Seq_THP-1_Human1.40781876
63MYB_26560356_Chip-Seq_TH1_Human1.37998374
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.35112589
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33700991
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.30467683
67GATA3_27048872_Chip-Seq_THYMUS_Human1.29832785
68ZNF263_19887448_ChIP-Seq_K562_Human1.29439738
69* GATA2_19941826_ChIP-Seq_K562_Human1.27305034
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27112015
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24921961
72RACK7_27058665_Chip-Seq_MCF-7_Human1.24774598
73CLOCK_20551151_ChIP-Seq_293T_Human1.24318274
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23473579
75NCOR1_26117541_ChIP-Seq_K562_Human1.23283659
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.21977734
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.21977734
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.20188230
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.19170324
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.18822240
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18792854
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17153691
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17153691
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16127347
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15608538
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15179489
87GATA4_25053715_ChIP-Seq_YYC3_Human1.14854133
88* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14373334
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.14141313
90GATA6_25053715_ChIP-Seq_YYC3_Human1.13964433
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.13910228
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11485043
93KDM2B_26808549_Chip-Seq_K562_Human1.10528807
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10167287
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09929633
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.09926249
97* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09878714
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08318017
99TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08198247
100MYB_26560356_Chip-Seq_TH2_Human1.07377574
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07117647
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06665123
103VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06285757
104* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05861420
105PU_27001747_Chip-Seq_BMDM_Mouse1.04403566
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04341796
107* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03158675
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01812484
109* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01611873
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01464544
111* SPI1_23547873_ChIP-Seq_NB4_Human1.01067145
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00764056
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00453616
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99522942
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97672709
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.97294402
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96495502
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96264423
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95766708
120* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95399208
121* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95294620
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94920206
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94063173
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94006894
125VDR_24787735_ChIP-Seq_THP-1_Human0.93047890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.34347126
2MP0005670_abnormal_white_adipose3.14998864
3MP0005360_urolithiasis3.10311166
4MP0005365_abnormal_bile_salt2.91248538
5MP0009840_abnormal_foam_cell2.72184432
6MP0002009_preneoplasia2.63851056
7MP0003191_abnormal_cellular_cholesterol2.60447086
8MP0000569_abnormal_digit_pigmentation2.54237897
9MP0005085_abnormal_gallbladder_physiolo2.52583248
10MP0003705_abnormal_hypodermis_morpholog2.33088503
11MP0009278_abnormal_bone_marrow2.31742581
12MP0003252_abnormal_bile_duct2.30912868
13MP0005397_hematopoietic_system_phenotyp2.20711827
14MP0001545_abnormal_hematopoietic_system2.20711827
15MP0003300_gastrointestinal_ulcer2.13142473
16MP0010329_abnormal_lipoprotein_level2.09284390
17MP0002396_abnormal_hematopoietic_system2.09250248
18MP0005058_abnormal_lysosome_morphology2.08256712
19MP0004130_abnormal_muscle_cell2.02715212
20MP0005666_abnormal_adipose_tissue2.01089155
21MP0004185_abnormal_adipocyte_glucose1.99616086
22MP0003763_abnormal_thymus_physiology1.92124665
23MP0008057_abnormal_DNA_replication1.87820935
24MP0004264_abnormal_extraembryonic_tissu1.84471868
25MP0008961_abnormal_basal_metabolism1.75855938
26MP0003303_peritoneal_inflammation1.69318061
27MP0000609_abnormal_liver_physiology1.67855406
28MP0005409_darkened_coat_color1.66538580
29MP0003828_pulmonary_edema1.65332395
30MP0003566_abnormal_cell_adhesion1.64697220
31MP0004808_abnormal_hematopoietic_stem1.62097554
32MP0005076_abnormal_cell_differentiation1.61515948
33MP0004510_myositis1.60856984
34MP0004381_abnormal_hair_follicle1.60433121
35MP0005464_abnormal_platelet_physiology1.59722632
36MP0003172_abnormal_lysosome_physiology1.57334211
37MP0002166_altered_tumor_susceptibility1.56732094
38MP0000383_abnormal_hair_follicle1.56075175
39MP0010234_abnormal_vibrissa_follicle1.55139338
40MP0003195_calcinosis1.51116835
41MP0002796_impaired_skin_barrier1.48557124
42MP0010678_abnormal_skin_adnexa1.47349716
43MP0005451_abnormal_body_composition1.42856466
44MP0001666_abnormal_nutrient_absorption1.40831198
45MP0010630_abnormal_cardiac_muscle1.40448086
46MP0003436_decreased_susceptibility_to1.33596265
47MP0005319_abnormal_enzyme/_coenzyme1.29864346
48MP0005083_abnormal_biliary_tract1.27376178
49MP0008875_abnormal_xenobiotic_pharmacok1.27134467
50MP0002254_reproductive_system_inflammat1.26871464
51MP0002118_abnormal_lipid_homeostasis1.25745997
52MP0005375_adipose_tissue_phenotype1.25187942
53MP0003045_fibrosis1.20374644
54MP0001835_abnormal_antigen_presentation1.20127872
55MP0002419_abnormal_innate_immunity1.19274904
56MP0002971_abnormal_brown_adipose1.18370565
57MP0000015_abnormal_ear_pigmentation1.17805807
58MP0001661_extended_life_span1.16492988
59MP0002405_respiratory_system_inflammati1.15013067
60MP0003656_abnormal_erythrocyte_physiolo1.14798990
61MP0010352_gastrointestinal_tract_polyps1.14053252
62MP0002998_abnormal_bone_remodeling1.13174552
63MP0004084_abnormal_cardiac_muscle1.11787114
64MP0003646_muscle_fatigue1.10657559
65MP0002420_abnormal_adaptive_immunity1.09193131
66MP0001819_abnormal_immune_cell1.08722584
67MP0002928_abnormal_bile_duct1.08060497
68MP0004087_abnormal_muscle_fiber1.07827036
69MP0005310_abnormal_salivary_gland1.07076944
70MP0004947_skin_inflammation1.06991154
71MP0009115_abnormal_fat_cell1.05766411
72MP0001800_abnormal_humoral_immune1.05092948
73MP0002006_tumorigenesis1.04828964
74MP0005000_abnormal_immune_tolerance1.04488778
75MP0001873_stomach_inflammation1.04410274
76MP0004782_abnormal_surfactant_physiolog1.04220829
77MP0003075_altered_response_to1.04184410
78MP0003453_abnormal_keratinocyte_physiol1.03851925
79MP0000685_abnormal_immune_system1.03676223
80MP0000598_abnormal_liver_morphology0.99816704
81MP0010307_abnormal_tumor_latency0.99596235
82MP0005330_cardiomyopathy0.99045575
83MP0000716_abnormal_immune_system0.95642938
84MP0005220_abnormal_exocrine_pancreas0.94545519
85MP0001851_eye_inflammation0.94362647
86MP0003183_abnormal_peptide_metabolism0.93861921
87MP0001216_abnormal_epidermal_layer0.93520583
88MP0005334_abnormal_fat_pad0.92386973
89MP0005075_abnormal_melanosome_morpholog0.92332924
90MP0000003_abnormal_adipose_tissue0.92058426
91MP0010368_abnormal_lymphatic_system0.91227309
92MP0002452_abnormal_antigen_presenting0.90999670
93MP0005025_abnormal_response_to0.90834439
94MP0005647_abnormal_sex_gland0.89878728
95MP0008469_abnormal_protein_level0.89334060
96MP0005174_abnormal_tail_pigmentation0.88460723
97MP0001790_abnormal_immune_system0.88448940
98MP0005387_immune_system_phenotype0.88448940
99MP0001849_ear_inflammation0.88307198
100MP0002132_abnormal_respiratory_system0.87618711
101MP0002098_abnormal_vibrissa_morphology0.87285433
102MP0002269_muscular_atrophy0.86514549
103MP0005671_abnormal_response_to0.86408254
104MP0010155_abnormal_intestine_physiology0.84777683
105MP0009333_abnormal_splenocyte_physiolog0.84690718
106MP0009931_abnormal_skin_appearance0.84669501
107MP0008995_early_reproductive_senescence0.84347067
108MP0002148_abnormal_hypersensitivity_rea0.84090073
109MP0000751_myopathy0.82940640
110MP0002429_abnormal_blood_cell0.82147559
111MP0002398_abnormal_bone_marrow0.82076149
112MP0002933_joint_inflammation0.82063541
113MP0009763_increased_sensitivity_to0.81958920
114MP0000689_abnormal_spleen_morphology0.81577443
115MP0003724_increased_susceptibility_to0.81168424
116MP0000703_abnormal_thymus_morphology0.81039913
117MP0005385_cardiovascular_system_phenoty0.80652407
118MP0001544_abnormal_cardiovascular_syste0.80652407
119MP0000371_diluted_coat_color0.79991558
120MP0000767_abnormal_smooth_muscle0.79620581
121MP0002722_abnormal_immune_system0.78780616
122MP0002837_dystrophic_cardiac_calcinosis0.78344762
123MP0005275_abnormal_skin_tensile0.78129126
124MP0005167_abnormal_blood-brain_barrier0.78107040
125MP0002138_abnormal_hepatobiliary_system0.77900400
126MP0009643_abnormal_urine_homeostasis0.77509299
127MP0005332_abnormal_amino_acid0.76917512
128MP0009764_decreased_sensitivity_to0.76761753
129MP0005023_abnormal_wound_healing0.76274627
130MP0001845_abnormal_inflammatory_respons0.75651973
131MP0001915_intracranial_hemorrhage0.75320708
132MP0002723_abnormal_immune_serum0.75284294
133MP0000465_gastrointestinal_hemorrhage0.74345086
134MP0004215_abnormal_myocardial_fiber0.73582443
135MP0002060_abnormal_skin_morphology0.72704975
136MP0001853_heart_inflammation0.72225834
137MP0005584_abnormal_enzyme/coenzyme_acti0.71457828
138MP0002086_abnormal_extraembryonic_tissu0.71305633

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal septum (HP:0000419)3.49270276
2Lip pit (HP:0100267)3.44298879
3Abnormality of the fingertips (HP:0001211)3.41751525
4Acute myeloid leukemia (HP:0004808)3.14343744
5Genetic anticipation (HP:0003743)3.09644548
6Complement deficiency (HP:0004431)3.08705090
7Urethral obstruction (HP:0000796)2.93736480
8Cerebral aneurysm (HP:0004944)2.90120310
9Myocardial infarction (HP:0001658)2.85859918
10Abnormality of secondary sexual hair (HP:0009888)2.80550647
11Abnormality of the axillary hair (HP:0100134)2.80550647
12Autoimmune thrombocytopenia (HP:0001973)2.79937487
13Right ventricular cardiomyopathy (HP:0011663)2.74512491
14Periodontitis (HP:0000704)2.71616826
15Deep venous thrombosis (HP:0002625)2.71162870
16Recurrent bacterial skin infections (HP:0005406)2.67745248
17Systemic lupus erythematosus (HP:0002725)2.64024947
18Increased connective tissue (HP:0009025)2.62882782
19Xanthomatosis (HP:0000991)2.59928788
20Hypoalphalipoproteinemia (HP:0003233)2.52557952
21Abnormality of the columella (HP:0009929)2.47879472
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.47563447
23Pustule (HP:0200039)2.46788984
24Hypercholesterolemia (HP:0003124)2.43388271
25Abnormality of complement system (HP:0005339)2.41865123
26Hyperglycinuria (HP:0003108)2.40515066
27Hematochezia (HP:0002573)2.38979485
28Ventricular tachycardia (HP:0004756)2.37544917
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.36284742
30Recurrent abscess formation (HP:0002722)2.34963913
31Recurrent gram-negative bacterial infections (HP:0005420)2.33883707
32Increased IgE level (HP:0003212)2.32990101
33Hyperkalemia (HP:0002153)2.31921462
34Polycythemia (HP:0001901)2.29899314
35Prolonged bleeding time (HP:0003010)2.29706283
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28530910
37Submucous cleft hard palate (HP:0000176)2.28132540
38Dysmetric saccades (HP:0000641)2.26929442
39Glomerulonephritis (HP:0000099)2.25578696
40Hypoglycemic coma (HP:0001325)2.25215352
41Recurrent cutaneous fungal infections (HP:0011370)2.24450532
42Chronic mucocutaneous candidiasis (HP:0002728)2.24450532
43Atrioventricular block (HP:0001678)2.24157820
44Asymmetric septal hypertrophy (HP:0001670)2.22415233
45Impaired platelet aggregation (HP:0003540)2.21966054
46Abnormal platelet function (HP:0011869)2.21966054
47Toxemia of pregnancy (HP:0100603)2.19633199
48Intrahepatic cholestasis (HP:0001406)2.18975549
49Inflammation of the large intestine (HP:0002037)2.17825812
50Esophageal varix (HP:0002040)2.16854459
51Eczematoid dermatitis (HP:0000976)2.14880545
52Neonatal hypoglycemia (HP:0001998)2.14511888
53Gingival bleeding (HP:0000225)2.13067563
54Ureteral obstruction (HP:0006000)2.12905846
55Long eyelashes (HP:0000527)2.11493831
56Fair hair (HP:0002286)2.10756639
57Broad metatarsal (HP:0001783)2.10624473
58Gastrointestinal inflammation (HP:0004386)2.09983066
59Ketosis (HP:0001946)2.09157494
60Sparse lateral eyebrow (HP:0005338)2.08807160
61Persistence of primary teeth (HP:0006335)2.08153293
62Hemorrhage of the eye (HP:0011885)2.07586382
63Aneurysm (HP:0002617)2.06738988
64Anal stenosis (HP:0002025)2.06154364
65Colitis (HP:0002583)2.05348034
66Acute lymphatic leukemia (HP:0006721)2.05065522
67Duplicated collecting system (HP:0000081)2.04827753
68Abnormality of the renal collecting system (HP:0004742)2.04723860
69Autoimmune hemolytic anemia (HP:0001890)2.03901931
70Macroorchidism (HP:0000053)2.03428340
71Hyperlipoproteinemia (HP:0010980)2.03410326
72Fatigue (HP:0012378)2.03350308
73Bundle branch block (HP:0011710)2.02286861
74Hyperammonemia (HP:0001987)2.02281459
75Sudden death (HP:0001699)2.02016998
76Epistaxis (HP:0000421)2.00095401
77Abnormality of the common coagulation pathway (HP:0010990)1.99867806
78Nephritis (HP:0000123)1.98661005
79Reticulocytosis (HP:0001923)1.98347716
80Axonal loss (HP:0003447)1.96973137
81Recurrent fungal infections (HP:0002841)1.95987816
82Decreased circulating renin level (HP:0003351)1.95080421
83Gingivitis (HP:0000230)1.94819556
84Abnormality of the left ventricular outflow tract (HP:0011103)1.94759473
85Subaortic stenosis (HP:0001682)1.94759473
86Ureteral stenosis (HP:0000071)1.94759090
87Hyperglycinemia (HP:0002154)1.94496229
88Joint hemorrhage (HP:0005261)1.94334731
89Abnormality of serine family amino acid metabolism (HP:0010894)1.93177420
90Abnormality of glycine metabolism (HP:0010895)1.93177420
91Recurrent viral infections (HP:0004429)1.92789658
92Malnutrition (HP:0004395)1.92439242
93Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91749472
94Hamartoma of the eye (HP:0010568)1.89799411
95Hypolipoproteinemia (HP:0010981)1.89558308
96Alopecia of scalp (HP:0002293)1.89477889
97Abnormality of the thoracic spine (HP:0100711)1.89059550
98Epidermoid cyst (HP:0200040)1.88888370
99Viral hepatitis (HP:0006562)1.88842025
100Panhypogammaglobulinemia (HP:0003139)1.88246730
101Facial diplegia (HP:0001349)1.88200706
102Prostate neoplasm (HP:0100787)1.87782616
103Spontaneous hematomas (HP:0007420)1.87133762
104Thoracic kyphosis (HP:0002942)1.86538697
105Recurrent skin infections (HP:0001581)1.84162903
106Arterial thrombosis (HP:0004420)1.83893039
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83408097
108Acanthocytosis (HP:0001927)1.82615542
109Abnormality of polysaccharide metabolism (HP:0011012)1.82175859
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82175859
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82175859
112Generalized hypopigmentation of hair (HP:0011358)1.82137762
113Mucopolysacchariduria (HP:0008155)1.82100420
114Urinary glycosaminoglycan excretion (HP:0003541)1.82100420
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81503200
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.80920944
117Coarse hair (HP:0002208)1.80395975
118Advanced eruption of teeth (HP:0006288)1.80124783
119Ectropion (HP:0000656)1.79460962
120Broad face (HP:0000283)1.79339811
121Abnormality of pyrimidine metabolism (HP:0004353)1.79243560
122Ventricular arrhythmia (HP:0004308)1.79025791
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78755027
124Heart block (HP:0012722)1.78636985
125Cellulitis (HP:0100658)1.77935303
126Poikilocytosis (HP:0004447)1.77718590
127Dislocated radial head (HP:0003083)1.76758146
128Hyperglycemia (HP:0003074)1.76313190
129Global brain atrophy (HP:0002283)1.76219904
130Prominent nose (HP:0000448)1.76174026
131Abnormality of T cell physiology (HP:0011840)1.75989762
132Clumsiness (HP:0002312)1.75650304
133Thick nail (HP:0001805)1.74981864
134Abnormality of transition element cation homeostasis (HP:0011030)1.74467409
135Skin nodule (HP:0200036)1.74275787
136Upper motor neuron abnormality (HP:0002127)1.73407843
137Neonatal death (HP:0003811)1.72727411
138Truncal obesity (HP:0001956)1.71392761
139Sandal gap (HP:0001852)1.71240581
140Difficulty running (HP:0009046)1.70617152
141Enlarged penis (HP:0000040)1.70415672
142Pigmentary retinal degeneration (HP:0001146)1.69519778
143Distal lower limb amyotrophy (HP:0008944)1.69317499
144Narrow palate (HP:0000189)1.68705597
145Flat acetabular roof (HP:0003180)1.67965978
146Hyporeflexia of lower limbs (HP:0002600)1.67965454
147Germ cell neoplasia (HP:0100728)1.67848815
148Abnormality of purine metabolism (HP:0004352)1.67513958
149Chronic diarrhea (HP:0002028)1.67503179
150Abnormal atrioventricular conduction (HP:0005150)1.67375904
151Distal lower limb muscle weakness (HP:0009053)1.66180822
152Oligodontia (HP:0000677)1.65478995
153Increased serum ferritin (HP:0003281)1.65395742
154Abnormality of the intrinsic pathway (HP:0010989)1.65386825
155Difficulty climbing stairs (HP:0003551)1.65383598
156Exercise-induced myalgia (HP:0003738)1.65033331
157Increased cerebral lipofuscin (HP:0011813)1.65031098
158Abnormality of iron homeostasis (HP:0011031)1.64909123
159Myoglobinuria (HP:0002913)1.64523175
160Depressed nasal tip (HP:0000437)1.64522771
161Palmoplantar hyperkeratosis (HP:0000972)1.64425837
162Osteolytic defects of the hand bones (HP:0009699)1.63528989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.26991715
2RIPK13.09528278
3CAMK1D3.04470425
4CDK122.87358581
5PKN22.70612214
6TRIB32.65960320
7TAOK32.57733636
8CAMK1G2.48687604
9MAP3K102.40549878
10SIK12.30939920
11MAP4K12.29624033
12LATS11.95417858
13TYK21.69644966
14TGFBR21.69381117
15PTK61.65873544
16TTN1.64676841
17EEF2K1.61626069
18BLK1.57901100
19PRKAA21.52210265
20ACVR1B1.50874625
21RIPK41.50272827
22JAK11.39925734
23PIK3CG1.38680362
24MAP3K71.34262641
25HIPK21.30904438
26STK31.27898931
27FLT31.27174780
28PRPF4B1.26689580
29KIT1.25920962
30DMPK1.20565754
31SMG11.18890753
32NLK1.18756356
33IRAK31.17669432
34MAP2K31.16901349
35MAP3K21.16403338
36BRD41.16096446
37STK381.12857796
38MAP3K131.11115257
39SIK21.10258979
40MTOR1.07951279
41PIK3CA1.07253446
42CDK61.07035649
43SGK31.06991344
44INSRR1.04641680
45MELK1.03643395
46CDK41.02557636
47WNK11.00610074
48CSF1R1.00294706
49TAOK10.99919915
50FGFR40.98406943
51MAPKAPK30.98124080
52STK100.97585095
53ITK0.94165739
54JAK20.93401714
55FER0.93275426
56BCKDK0.92656416
57ZAP700.91459291
58MAPK110.91197171
59RPS6KB20.90692843
60HCK0.89649541
61NEK20.87575167
62MAP3K10.86498474
63CSK0.84201750
64TBK10.82792750
65TNK20.82565374
66MAP3K30.82258658
67CAMK40.82048316
68MATK0.81617005
69PRKAA10.81239356
70MARK20.79896726
71TXK0.78861671
72JAK30.78516765
73MST1R0.78253876
74ICK0.77796379
75MAP3K140.77634974
76FGFR30.75153374
77BTK0.75070597
78STK40.74894159
79MAP2K60.72885194
80CHUK0.71174290
81EPHA20.68792210
82IRAK10.68500059
83FES0.66582513
84CAMK10.65107018
85STK390.64405249
86PIM10.61201544
87CDK90.61059762
88EPHB10.60912296
89MAPK120.60499707
90LCK0.60428626
91BMX0.60277351
92GRK60.59590520
93RPS6KA60.59511799
94SGK20.58801925
95WNK40.57912886
96RPS6KL10.57661370
97PDGFRB0.57188727
98MAPK30.57036372
99PRKD10.55027981
100PDGFRA0.55015156
101IKBKE0.53527478
102PDK10.52896207
103EPHA30.52544819
104MAP2K20.51804965
105STK240.51174210
106DAPK20.50980490
107MAPK10.50187564
108CDC42BPA0.50079050
109TRPM70.49853318
110ALK0.49648009
111PTK20.48900725
112PRKD20.48786095
113IKBKB0.48571605
114BMPR20.47898581
115MAPK70.47405702
116TIE10.46858780
117FRK0.46223594
118TEC0.46052343
119MKNK20.45773110
120PDPK10.44584297
121KDR0.43927358
122LMTK20.43800195
123CAMKK10.43666394
124AKT30.42894704
125ZAK0.42509464
126SCYL20.42028435
127MAP3K60.41382698
128LRRK20.40921206
129ERBB20.40507752
130SYK0.40394769
131PINK10.40121455
132RPS6KC10.40001052

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.87615787
2Lysine degradation_Homo sapiens_hsa003102.66739226
3Staphylococcus aureus infection_Homo sapiens_hsa051502.26458353
4Caffeine metabolism_Homo sapiens_hsa002322.20638710
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.20414021
6Arginine biosynthesis_Homo sapiens_hsa002202.10490193
7Fatty acid degradation_Homo sapiens_hsa000712.07308612
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01457178
9PPAR signaling pathway_Homo sapiens_hsa033201.95678802
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85476161
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79445287
12Complement and coagulation cascades_Homo sapiens_hsa046101.79257805
13ABC transporters_Homo sapiens_hsa020101.74193670
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.65368617
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61283104
16Starch and sucrose metabolism_Homo sapiens_hsa005001.41389590
17Insulin resistance_Homo sapiens_hsa049311.39674105
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38143293
19Bile secretion_Homo sapiens_hsa049761.38027618
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35166058
21Tryptophan metabolism_Homo sapiens_hsa003801.32499617
22Asthma_Homo sapiens_hsa053101.30226257
23Fatty acid metabolism_Homo sapiens_hsa012121.30175308
24Type II diabetes mellitus_Homo sapiens_hsa049301.29208448
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27617785
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26317294
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.26073157
28Vitamin digestion and absorption_Homo sapiens_hsa049771.23304062
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22811926
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.19750435
31Osteoclast differentiation_Homo sapiens_hsa043801.18854551
32Propanoate metabolism_Homo sapiens_hsa006401.18554247
33Fatty acid biosynthesis_Homo sapiens_hsa000611.18302474
34B cell receptor signaling pathway_Homo sapiens_hsa046621.16896772
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11877309
36T cell receptor signaling pathway_Homo sapiens_hsa046601.11843470
37Allograft rejection_Homo sapiens_hsa053301.08477882
38Selenocompound metabolism_Homo sapiens_hsa004501.06463070
39Autoimmune thyroid disease_Homo sapiens_hsa053201.05711926
40Fat digestion and absorption_Homo sapiens_hsa049751.05247785
41TNF signaling pathway_Homo sapiens_hsa046681.05240674
42Graft-versus-host disease_Homo sapiens_hsa053321.05097478
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03065422
44Acute myeloid leukemia_Homo sapiens_hsa052211.00290912
45Linoleic acid metabolism_Homo sapiens_hsa005910.98885199
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97679302
47Prostate cancer_Homo sapiens_hsa052150.97291987
48Glycerolipid metabolism_Homo sapiens_hsa005610.97224445
49Chronic myeloid leukemia_Homo sapiens_hsa052200.96778942
50beta-Alanine metabolism_Homo sapiens_hsa004100.95225043
51Galactose metabolism_Homo sapiens_hsa000520.95212141
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.95154491
53Leishmaniasis_Homo sapiens_hsa051400.94256583
54Histidine metabolism_Homo sapiens_hsa003400.92609194
55Hepatitis C_Homo sapiens_hsa051600.91912870
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91898149
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.90206267
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89274673
59Prolactin signaling pathway_Homo sapiens_hsa049170.88340324
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87586154
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87559308
62Pancreatic cancer_Homo sapiens_hsa052120.86538711
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.86352419
64Retinol metabolism_Homo sapiens_hsa008300.85851688
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84926472
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84328540
67Carbon metabolism_Homo sapiens_hsa012000.83882125
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82864636
69Primary immunodeficiency_Homo sapiens_hsa053400.82504080
70Systemic lupus erythematosus_Homo sapiens_hsa053220.82285698
71Dilated cardiomyopathy_Homo sapiens_hsa054140.81410494
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81228689
73mTOR signaling pathway_Homo sapiens_hsa041500.80011908
74Platelet activation_Homo sapiens_hsa046110.79222195
75MicroRNAs in cancer_Homo sapiens_hsa052060.78711407
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77988928
77Lysosome_Homo sapiens_hsa041420.77434502
78AMPK signaling pathway_Homo sapiens_hsa041520.76910844
79Thyroid cancer_Homo sapiens_hsa052160.76081246
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76048233
81Peroxisome_Homo sapiens_hsa041460.75697640
82Renal cell carcinoma_Homo sapiens_hsa052110.74418449
83Insulin signaling pathway_Homo sapiens_hsa049100.73271198
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72560606
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72104561
86Chemical carcinogenesis_Homo sapiens_hsa052040.71808873
87Choline metabolism in cancer_Homo sapiens_hsa052310.71689685
88Pentose phosphate pathway_Homo sapiens_hsa000300.71584329
89Fructose and mannose metabolism_Homo sapiens_hsa000510.71135342
90Toxoplasmosis_Homo sapiens_hsa051450.70230186
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69088197
92Notch signaling pathway_Homo sapiens_hsa043300.68893894
93Small cell lung cancer_Homo sapiens_hsa052220.68660807
94Circadian rhythm_Homo sapiens_hsa047100.68486943
95Other glycan degradation_Homo sapiens_hsa005110.66401205
96Adherens junction_Homo sapiens_hsa045200.65367541
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.64998230
98Type I diabetes mellitus_Homo sapiens_hsa049400.64952072
99VEGF signaling pathway_Homo sapiens_hsa043700.64144546
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.63006876
101Biosynthesis of amino acids_Homo sapiens_hsa012300.61756880
102Amoebiasis_Homo sapiens_hsa051460.61063817
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60047930
104Non-small cell lung cancer_Homo sapiens_hsa052230.59911784
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59682929
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.58919232
107Glucagon signaling pathway_Homo sapiens_hsa049220.58768274
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57947442
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57735541
110Renin-angiotensin system_Homo sapiens_hsa046140.57259880
111Ovarian steroidogenesis_Homo sapiens_hsa049130.56860661
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56714938
113Viral carcinogenesis_Homo sapiens_hsa052030.56590098
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56542054
115Inositol phosphate metabolism_Homo sapiens_hsa005620.55705945
116Endometrial cancer_Homo sapiens_hsa052130.55154956
117Ether lipid metabolism_Homo sapiens_hsa005650.54464589
118Pertussis_Homo sapiens_hsa051330.52708665
119Influenza A_Homo sapiens_hsa051640.52411161
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.51561160
121HIF-1 signaling pathway_Homo sapiens_hsa040660.51550271
122GnRH signaling pathway_Homo sapiens_hsa049120.51216893
123Tuberculosis_Homo sapiens_hsa051520.51107478
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.50983419
125Proteoglycans in cancer_Homo sapiens_hsa052050.49967938
126Dorso-ventral axis formation_Homo sapiens_hsa043200.49219065
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47765091
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47116568
129FoxO signaling pathway_Homo sapiens_hsa040680.46954936
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.46380990
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44625938
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44569920
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43638984
134Focal adhesion_Homo sapiens_hsa045100.43515171
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.42790964
136Hematopoietic cell lineage_Homo sapiens_hsa046400.41374464
137Herpes simplex infection_Homo sapiens_hsa051680.40547410
138Hepatitis B_Homo sapiens_hsa051610.40541827
139Measles_Homo sapiens_hsa051620.40216647
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.38792318
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38252885

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »