RRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)9.96776600
2female mating behavior (GO:0060180)8.51731834
3gamma-aminobutyric acid transport (GO:0015812)7.99957575
4cellular response to electrical stimulus (GO:0071257)7.52132161
5neuronal action potential propagation (GO:0019227)6.60346456
6* protein-chromophore linkage (GO:0018298)6.05011191
7regulation of rhodopsin mediated signaling pathway (GO:0022400)5.55415342
8rhodopsin mediated signaling pathway (GO:0016056)5.23753782
9negative regulation of T cell receptor signaling pathway (GO:0050860)4.78996205
10positive regulation of cellular amide metabolic process (GO:0034250)4.61197897
11polyketide metabolic process (GO:0030638)4.60164442
12doxorubicin metabolic process (GO:0044598)4.60164442
13daunorubicin metabolic process (GO:0044597)4.60164442
14relaxation of smooth muscle (GO:0044557)4.55783959
15eye photoreceptor cell differentiation (GO:0001754)4.54817963
16photoreceptor cell differentiation (GO:0046530)4.54817963
17superoxide anion generation (GO:0042554)4.51630730
18detection of visible light (GO:0009584)4.45389622
19NLS-bearing protein import into nucleus (GO:0006607)4.43320865
20* detection of light stimulus (GO:0009583)4.40411543
21sodium-independent organic anion transport (GO:0043252)4.28935533
22retinal metabolic process (GO:0042574)4.24148606
23* visual perception (GO:0007601)4.22739274
24multicellular organismal reproductive behavior (GO:0033057)4.20541487
25response to pheromone (GO:0019236)4.20320468
26phototransduction, visible light (GO:0007603)4.19003610
27* sensory perception of light stimulus (GO:0050953)4.17306992
28* phototransduction (GO:0007602)4.09756549
29fat-soluble vitamin metabolic process (GO:0006775)4.08466131
30retina development in camera-type eye (GO:0060041)4.06020532
31regulation of DNA-templated transcription, initiation (GO:2000142)3.83671958
32negative regulation of myotube differentiation (GO:0010832)3.83179236
33positive regulation of cGMP biosynthetic process (GO:0030828)3.82575252
34positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.81688966
35negative regulation of mast cell activation (GO:0033004)3.81610474
36negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.80667587
37positive regulation of guanylate cyclase activity (GO:0031284)3.79376046
38regulation of cGMP metabolic process (GO:0030823)3.78159246
39phosphatidylinositol acyl-chain remodeling (GO:0036149)3.72037040
40nephron tubule formation (GO:0072079)3.71398838
41regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.66166162
42retinol metabolic process (GO:0042572)3.66142109
43cell-cell junction maintenance (GO:0045217)3.65585466
44response to peptidoglycan (GO:0032494)3.64393714
45behavioral response to nicotine (GO:0035095)3.62955574
46regulation of cGMP biosynthetic process (GO:0030826)3.54875670
47dendritic cell chemotaxis (GO:0002407)3.52708663
48Sertoli cell development (GO:0060009)3.52529069
49short-term memory (GO:0007614)3.51405081
50adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.50577991
51neutrophil activation involved in immune response (GO:0002283)3.47808791
52keratinocyte development (GO:0003334)3.47317374
53energy homeostasis (GO:0097009)3.41815125
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41651047
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.40891517
56positive regulation of cGMP metabolic process (GO:0030825)3.36665721
57regulation of guanylate cyclase activity (GO:0031282)3.35784976
58phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.24776450
59* detection of abiotic stimulus (GO:0009582)3.24382573
60* detection of external stimulus (GO:0009581)3.24362861
61transmission of nerve impulse (GO:0019226)3.23437731
62positive regulation of vascular permeability (GO:0043117)3.21795721
63dendritic cell migration (GO:0036336)3.21169075
64detection of molecule of bacterial origin (GO:0032490)3.20524771
65long term synaptic depression (GO:0060292)3.18379036
66detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.15317513
67urate metabolic process (GO:0046415)3.12319969
68photoreceptor cell maintenance (GO:0045494)3.11642869
69phosphatidylserine acyl-chain remodeling (GO:0036150)3.11113394
70natural killer cell activation involved in immune response (GO:0002323)3.08950579
71serotonin metabolic process (GO:0042428)3.08879579
72meiotic chromosome segregation (GO:0045132)3.06006931
73maturation of 5.8S rRNA (GO:0000460)3.01648040
74neuronal action potential (GO:0019228)2.99355936
75hydrogen peroxide catabolic process (GO:0042744)2.99316267
76cell junction maintenance (GO:0034331)2.96708157
77regulation of voltage-gated calcium channel activity (GO:1901385)2.92533196
78photoreceptor cell development (GO:0042461)2.92231745
79behavioral response to ethanol (GO:0048149)2.91771199
80negative regulation of myeloid cell apoptotic process (GO:0033033)2.90913209
81neutrophil activation (GO:0042119)2.88438718
82regulation of activation of Janus kinase activity (GO:0010533)2.87379805
83eosinophil chemotaxis (GO:0048245)2.86937975
84detection of other organism (GO:0098543)2.86863356
85eye photoreceptor cell development (GO:0042462)2.86649662
86DNA synthesis involved in DNA repair (GO:0000731)2.86443981
87production of molecular mediator involved in inflammatory response (GO:0002532)2.85227745
88vocalization behavior (GO:0071625)2.84624575
89multi-organism reproductive behavior (GO:0044705)2.84165236
90sensory perception of chemical stimulus (GO:0007606)2.83232076
91cytoplasmic microtubule organization (GO:0031122)2.81911783
92otic vesicle formation (GO:0030916)2.81436350
93extracellular negative regulation of signal transduction (GO:1900116)2.79829641
94extracellular regulation of signal transduction (GO:1900115)2.79829641
95positive regulation of extracellular matrix organization (GO:1903055)2.79593970
96glomerular visceral epithelial cell development (GO:0072015)2.79266748
97reproductive behavior (GO:0019098)2.79165124
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78684654
99regulation of RIG-I signaling pathway (GO:0039535)2.77101945
100positive regulation of DNA-templated transcription, initiation (GO:2000144)2.76409342
101detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.75996332
102cAMP metabolic process (GO:0046058)2.73179569
103DNA integration (GO:0015074)2.71809756
104presynaptic membrane assembly (GO:0097105)2.71029055
105primary amino compound metabolic process (GO:1901160)2.68567541
106retinal rod cell development (GO:0046548)2.68148215
107positive regulation of interleukin-1 beta secretion (GO:0050718)2.67995156
108positive regulation of antigen processing and presentation (GO:0002579)2.67993228
109aminoglycoside antibiotic metabolic process (GO:0030647)2.67889208
110granulocyte activation (GO:0036230)2.67597915
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65851021
112regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64186431
113startle response (GO:0001964)2.63161326
114interferon-gamma production (GO:0032609)2.62873202
115regulation of mast cell activation (GO:0033003)2.62849159
116regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.61258679
117presynaptic membrane organization (GO:0097090)2.60785661
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60607388
119regulation of mitotic spindle checkpoint (GO:1903504)2.60607388
120rRNA methylation (GO:0031167)2.59698287
121negative regulation of viral genome replication (GO:0045071)2.59294561
122positive regulation of heat generation (GO:0031652)2.59240085
123tachykinin receptor signaling pathway (GO:0007217)2.58585271
124regulation of antigen processing and presentation (GO:0002577)2.57992107
125regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.57986315
126somite development (GO:0061053)2.57909060
127oligosaccharide catabolic process (GO:0009313)2.57152068
128adenosine metabolic process (GO:0046085)2.55557530
129cAMP biosynthetic process (GO:0006171)2.54875155
130centriole assembly (GO:0098534)2.54835135
131toxin metabolic process (GO:0009404)2.54439368
132DNA strand renaturation (GO:0000733)2.54142875
133cytochrome complex assembly (GO:0017004)2.53344179
134response to electrical stimulus (GO:0051602)2.51208019
135regulation of inositol phosphate biosynthetic process (GO:0010919)2.51179859
136* sensory perception (GO:0007600)2.50514211
137eosinophil migration (GO:0072677)2.49905335
138superoxide metabolic process (GO:0006801)2.49618655
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.48567899
140regulation of fever generation (GO:0031620)2.47899066
141Peyers patch development (GO:0048541)2.47647719
142mucosal-associated lymphoid tissue development (GO:0048537)2.47647719
143protein heterotetramerization (GO:0051290)2.46237955
144viral entry into host cell (GO:0046718)2.46109206
145phasic smooth muscle contraction (GO:0014821)2.44344296
146positive regulation by symbiont of host defense response (GO:0052509)2.44082656
147modulation by symbiont of host defense response (GO:0052031)2.44082656
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44082656
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44082656
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.44082656
151modulation by symbiont of host immune response (GO:0052553)2.44082656
152positive regulation of monocyte chemotaxis (GO:0090026)2.43958637
153limb bud formation (GO:0060174)2.43645097
154hydrogen peroxide biosynthetic process (GO:0050665)2.43009028
155poly(A)+ mRNA export from nucleus (GO:0016973)2.42898711
156respiratory burst (GO:0045730)2.42538386
157lipoxygenase pathway (GO:0019372)2.42307087
158positive regulation of interleukin-1 secretion (GO:0050716)2.42171248
159histone H3-K36 demethylation (GO:0070544)2.41594228
160regulation of T cell receptor signaling pathway (GO:0050856)2.39245542
161pyrimidine dimer repair (GO:0006290)2.39010538
162regulation of hexokinase activity (GO:1903299)2.38881334
163regulation of glucokinase activity (GO:0033131)2.38881334
164regulation of interleukin-1 beta secretion (GO:0050706)2.38515387
165rRNA modification (GO:0000154)2.38457763
166kinetochore assembly (GO:0051382)2.37961510
167protein K6-linked ubiquitination (GO:0085020)2.36541132
168positive regulation of lymphocyte migration (GO:2000403)2.35753767
169reactive oxygen species biosynthetic process (GO:1903409)2.34405064
170myeloid dendritic cell activation (GO:0001773)2.34041658
171DNA catabolic process, exonucleolytic (GO:0000738)2.33524174
172regulation of timing of cell differentiation (GO:0048505)2.33402641
173replicative senescence (GO:0090399)2.33379915
174positive regulation of T cell migration (GO:2000406)2.32793275
175NIK/NF-kappaB signaling (GO:0038061)2.31120712
176cellular response to gamma radiation (GO:0071480)2.30874209
177mannosylation (GO:0097502)2.30763003
178detection of external biotic stimulus (GO:0098581)2.30396969
179negative regulation of systemic arterial blood pressure (GO:0003085)2.30384472
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29022541
181positive regulation of protein sumoylation (GO:0033235)2.28175426
182DNA double-strand break processing (GO:0000729)2.26955370
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.26785352
184positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.26717780
185mesenchymal cell differentiation involved in renal system development (GO:2001012)2.26351381
186mesenchymal cell differentiation involved in kidney development (GO:0072161)2.26351381
187I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.25489253
188positive regulation of protein homodimerization activity (GO:0090073)2.25431290
189sequestering of actin monomers (GO:0042989)2.24768242
190histamine secretion (GO:0001821)2.24651328
191glycosphingolipid catabolic process (GO:0046479)2.24337461
192positive regulation of interferon-gamma production (GO:0032729)2.24240161
193positive regulation of interferon-alpha production (GO:0032727)2.23848763
194regulation of mast cell degranulation (GO:0043304)2.23082875
195vitamin A metabolic process (GO:0006776)16.7305035
196detection of light stimulus involved in visual perception (GO:0050908)11.3561205
197detection of light stimulus involved in sensory perception (GO:0050962)11.3561205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13370439
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.39416228
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.73483269
4GBX2_23144817_ChIP-Seq_PC3_Human3.19886158
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06810443
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.04696440
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.92377055
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.89554743
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.83843161
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55662622
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51562225
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46156792
13ZNF274_21170338_ChIP-Seq_K562_Hela2.45494428
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44250851
15E2F7_22180533_ChIP-Seq_HELA_Human2.38571758
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.30379451
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.26516633
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24542588
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08207716
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.99204090
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.96850886
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95483631
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91950742
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.91164104
25STAT3_18555785_Chip-Seq_ESCs_Mouse1.87776398
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87036355
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83262890
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83125455
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81666569
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80476482
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80320051
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79840063
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78068241
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.77933542
35AR_21572438_ChIP-Seq_LNCaP_Human1.77868639
36P53_22387025_ChIP-Seq_ESCs_Mouse1.77660513
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.75850168
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74860946
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.72774840
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.72628960
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72203312
42STAT3_23295773_ChIP-Seq_U87_Human1.71411317
43AR_25329375_ChIP-Seq_VCAP_Human1.70592092
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.68036418
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66970074
46EWS_26573619_Chip-Seq_HEK293_Human1.62414890
47BCAT_22108803_ChIP-Seq_LS180_Human1.61653562
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61569277
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.61380371
50P300_19829295_ChIP-Seq_ESCs_Human1.60896524
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.60686607
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.58966646
53CMYC_18555785_Chip-Seq_ESCs_Mouse1.58049573
54SOX2_18555785_Chip-Seq_ESCs_Mouse1.56421735
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55051499
56* TCF4_23295773_ChIP-Seq_U87_Human1.54875149
57ZFX_18555785_Chip-Seq_ESCs_Mouse1.54359964
58IGF1R_20145208_ChIP-Seq_DFB_Human1.52493830
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.50194852
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49922636
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49435542
62* P300_18555785_Chip-Seq_ESCs_Mouse1.49112026
63FUS_26573619_Chip-Seq_HEK293_Human1.47838261
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.47435515
65PU1_27457419_Chip-Seq_LIVER_Mouse1.47008468
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.46967713
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46677256
68RUNX2_22187159_ChIP-Seq_PCA_Human1.44596116
69DROSHA_22980978_ChIP-Seq_HELA_Human1.43775283
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43304742
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.41917441
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39862437
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39285984
74AHR_22903824_ChIP-Seq_MCF-7_Human1.39268795
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39110597
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39107229
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.38999346
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36608752
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36065148
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35954527
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.35723784
82KDM2B_26808549_Chip-Seq_REH_Human1.32816059
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32376982
84* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32307142
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31593524
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30628277
87REST_21632747_ChIP-Seq_MESCs_Mouse1.30467988
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.30350317
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29792335
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29716558
91IRF1_19129219_ChIP-ChIP_H3396_Human1.28280782
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27700360
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27516927
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27249737
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27032820
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.26569850
97ER_23166858_ChIP-Seq_MCF-7_Human1.26532918
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26521777
99RNF2_27304074_Chip-Seq_NSC_Mouse1.26462548
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.26149040
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.25418199
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.25203653
103TCF4_22108803_ChIP-Seq_LS180_Human1.25075279
104SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23253501
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22062939
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22062939
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21962520
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.21701296
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21560413
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20923551
111ELK1_19687146_ChIP-ChIP_HELA_Human1.20760304
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20226009
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19449157
114CJUN_26792858_Chip-Seq_BT549_Human1.19325192
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19102839
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17511581
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.16909002
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16681968
119EZH2_27304074_Chip-Seq_ESCs_Mouse1.15480921
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.15378379
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14502463
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13462765
123SMAD4_21799915_ChIP-Seq_A2780_Human1.11711600
124* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11464208
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11407268
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11407268
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.10820995
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10721076
129JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10309192
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10195043
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09586433
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.09297836
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08866425
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08539662
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07676080
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07594224
137VDR_22108803_ChIP-Seq_LS180_Human1.06267982
138RXR_22108803_ChIP-Seq_LS180_Human1.06193994
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05766753
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04423314
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04024730
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02955155
143KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02894266
144ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01703070
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00432768
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00191457
147TAF15_26573619_Chip-Seq_HEK293_Human0.99849164
148TBL1_22424771_ChIP-Seq_293T_Human0.99165760
149PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98923979
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98872919
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98603621
152GABP_17652178_ChIP-ChIP_JURKAT_Human0.98521654
153JUN_21703547_ChIP-Seq_K562_Human0.97814041
154TP53_16413492_ChIP-PET_HCT116_Human0.95884613
155SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94800947
156* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94753113
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94546125
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94300471
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.94114778
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.93077102
161HOXB7_26014856_ChIP-Seq_BT474_Human0.92870991
162MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91955252
163GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91372842
164STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91286963
165SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91074398
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.90932512
167TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90835775
168RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89457813
169AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88263592
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87894138
171CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87196535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.85599648
2MP0001835_abnormal_antigen_presentation3.33379467
3MP0005171_absent_coat_pigmentation3.19406634
4MP0009780_abnormal_chondrocyte_physiolo3.08434819
5MP0001188_hyperpigmentation3.06187213
6MP0004019_abnormal_vitamin_homeostasis2.73171039
7MP0002148_abnormal_hypersensitivity_rea2.59752222
8MP0009697_abnormal_copulation2.53313768
9MP0002638_abnormal_pupillary_reflex2.51205393
10MP0000566_synostosis2.46818578
11MP0000372_irregular_coat_pigmentation2.43915719
12MP0008058_abnormal_DNA_repair2.35381823
13MP0003011_delayed_dark_adaptation2.32205501
14MP0000015_abnormal_ear_pigmentation2.32013944
15MP0009785_altered_susceptibility_to2.29908873
16MP0005423_abnormal_somatic_nervous2.27400084
17MP0002277_abnormal_respiratory_mucosa2.15278489
18MP0002132_abnormal_respiratory_system2.13930863
19MP0005187_abnormal_penis_morphology2.13331993
20MP0002138_abnormal_hepatobiliary_system2.10381739
21MP0001986_abnormal_taste_sensitivity2.07337097
22MP0003136_yellow_coat_color2.05837195
23MP0002876_abnormal_thyroid_physiology2.04061829
24MP0005671_abnormal_response_to2.02439902
25MP0005646_abnormal_pituitary_gland1.89608299
26MP0003787_abnormal_imprinting1.84433192
27MP0002419_abnormal_innate_immunity1.83098588
28MP0004782_abnormal_surfactant_physiolog1.80591845
29MP0005391_vision/eye_phenotype1.80552903
30MP0010386_abnormal_urinary_bladder1.78609397
31MP0008260_abnormal_autophagy1.74579138
32MP0003724_increased_susceptibility_to1.73739613
33MP0008007_abnormal_cellular_replicative1.68255588
34MP0005000_abnormal_immune_tolerance1.67618437
35MP0006072_abnormal_retinal_apoptosis1.59502793
36MP0005645_abnormal_hypothalamus_physiol1.52752685
37MP0010030_abnormal_orbit_morphology1.52649237
38MP0002163_abnormal_gland_morphology1.52640703
39MP0005025_abnormal_response_to1.52315895
40MP0005075_abnormal_melanosome_morpholog1.51264709
41MP0005387_immune_system_phenotype1.50580552
42MP0001790_abnormal_immune_system1.50580552
43MP0003436_decreased_susceptibility_to1.49798617
44MP0002095_abnormal_skin_pigmentation1.48959081
45MP0002452_abnormal_antigen_presenting1.48738453
46MP0003879_abnormal_hair_cell1.47645227
47MP0010094_abnormal_chromosome_stability1.41607410
48MP0002090_abnormal_vision1.40894018
49MP0008877_abnormal_DNA_methylation1.37992755
50MP0002102_abnormal_ear_morphology1.35407391
51MP0005195_abnormal_posterior_eye1.34123258
52MP0002723_abnormal_immune_serum1.31339475
53MP0001819_abnormal_immune_cell1.29783209
54MP0001800_abnormal_humoral_immune1.28970084
55MP0009046_muscle_twitch1.28050458
56MP0002420_abnormal_adaptive_immunity1.27206549
57MP0005174_abnormal_tail_pigmentation1.27186805
58MP0005409_darkened_coat_color1.26289526
59MP0003786_premature_aging1.26186242
60MP0001119_abnormal_female_reproductive1.23818143
61MP0002938_white_spotting1.23750803
62MP0009764_decreased_sensitivity_to1.23332757
63MP0001186_pigmentation_phenotype1.22023094
64MP0008875_abnormal_xenobiotic_pharmacok1.18976340
65MP0005551_abnormal_eye_electrophysiolog1.17070309
66MP0001324_abnormal_eye_pigmentation1.15772388
67MP0002272_abnormal_nervous_system1.13944189
68MP0000681_abnormal_thyroid_gland1.13326884
69MP0003122_maternal_imprinting1.10017743
70MP0009333_abnormal_splenocyte_physiolog1.08622697
71MP0005310_abnormal_salivary_gland1.08196906
72MP0005379_endocrine/exocrine_gland_phen1.08142340
73MP0002909_abnormal_adrenal_gland1.07520503
74MP0004885_abnormal_endolymph1.07501402
75MP0003186_abnormal_redox_activity1.06898549
76MP0000631_abnormal_neuroendocrine_gland1.06554428
77MP0002075_abnormal_coat/hair_pigmentati1.05797026
78MP0003763_abnormal_thymus_physiology1.05202478
79MP0001968_abnormal_touch/_nociception1.05010787
80MP0003938_abnormal_ear_development1.04367901
81MP0002229_neurodegeneration1.03120653
82MP0000371_diluted_coat_color1.02050344
83MP0005253_abnormal_eye_physiology1.01380189
84MP0003718_maternal_effect1.00899094
85MP0000678_abnormal_parathyroid_gland0.98013811
86MP0005084_abnormal_gallbladder_morpholo0.93986775
87MP0006276_abnormal_autonomic_nervous0.93898504
88MP0004381_abnormal_hair_follicle0.93508633
89MP0001984_abnormal_olfaction0.92745479
90MP0005410_abnormal_fertilization0.90321989
91MP0003111_abnormal_nucleus_morphology0.90254876
92MP0002160_abnormal_reproductive_system0.90059496
93MP0008789_abnormal_olfactory_epithelium0.89964351
94MP0003890_abnormal_embryonic-extraembry0.89414151
95MP0001501_abnormal_sleep_pattern0.88927863
96MP0008057_abnormal_DNA_replication0.88515633
97MP0000685_abnormal_immune_system0.88080086
98MP0003183_abnormal_peptide_metabolism0.87945937
99MP0005464_abnormal_platelet_physiology0.87490562
100MP0000716_abnormal_immune_system0.86848334
101MP0005257_abnormal_intraocular_pressure0.86417375
102MP0005389_reproductive_system_phenotype0.86087690
103MP0002398_abnormal_bone_marrow0.85199809
104MP0006082_CNS_inflammation0.84959923
105MP0001845_abnormal_inflammatory_respons0.84756897
106MP0001853_heart_inflammation0.84604687
107MP0000490_abnormal_crypts_of0.84045267
108MP0002752_abnormal_somatic_nervous0.83011771
109MP0003123_paternal_imprinting0.82741072
110MP0001919_abnormal_reproductive_system0.81258596
111MP0001879_abnormal_lymphatic_vessel0.81094175
112MP0000569_abnormal_digit_pigmentation0.80895429
113MP0002405_respiratory_system_inflammati0.80606744
114MP0002396_abnormal_hematopoietic_system0.80236421
115MP0005408_hypopigmentation0.78252544
116MP0002736_abnormal_nociception_after0.77675989
117MP0002177_abnormal_outer_ear0.77183591
118MP0003119_abnormal_digestive_system0.75481011
119MP0002998_abnormal_bone_remodeling0.75273663
120MP0008004_abnormal_stomach_pH0.75085181
121MP0002233_abnormal_nose_morphology0.75017300
122MP0000026_abnormal_inner_ear0.73964252
123MP0001299_abnormal_eye_distance/0.73086100
124MP0001486_abnormal_startle_reflex0.71302903
125MP0003646_muscle_fatigue0.71212342
126MP0001502_abnormal_circadian_rhythm0.71005760
127MP0009745_abnormal_behavioral_response0.70706502
128MP0003941_abnormal_skin_development0.70438921
129MP0000689_abnormal_spleen_morphology0.69789979
130MP0002282_abnormal_trachea_morphology0.69364526
131MP0003121_genomic_imprinting0.69074050
132MP0001764_abnormal_homeostasis0.68878905
133MP0002429_abnormal_blood_cell0.67836807
134MP0002249_abnormal_larynx_morphology0.67559292
135MP0004147_increased_porphyrin_level0.67281963
136MP0008995_early_reproductive_senescence0.66663950
137MP0000049_abnormal_middle_ear0.66061765
138MP0008775_abnormal_heart_ventricle0.65615006
139MP0003633_abnormal_nervous_system0.60276862
140MP0000647_abnormal_sebaceous_gland0.59210379
141MP0005167_abnormal_blood-brain_barrier0.57932266
142MP0002092_abnormal_eye_morphology0.56721436
143MP0002653_abnormal_ependyma_morphology0.56587944
144MP0003638_abnormal_response/metabolism_0.55288753
145MP0002067_abnormal_sensory_capabilities0.54782690
146MP0002734_abnormal_mechanical_nocicepti0.54777693
147MP0005503_abnormal_tendon_morphology0.52393180
148MP0001485_abnormal_pinna_reflex0.52246838
149MP0005377_hearing/vestibular/ear_phenot0.51088380
150MP0003878_abnormal_ear_physiology0.51088380
151MP0004924_abnormal_behavior0.49705973
152MP0005386_behavior/neurological_phenoty0.49705973
153MP0003698_abnormal_male_reproductive0.49459297
154MP0002882_abnormal_neuron_morphology0.48831119
155MP0000534_abnormal_ureter_morphology0.48370772
156MP0004130_abnormal_muscle_cell0.48217126
157MP0002064_seizures0.47187460
158MP0001346_abnormal_lacrimal_gland0.46142593
159MP0002572_abnormal_emotion/affect_behav0.44818817
160MP0002210_abnormal_sex_determination0.44555881
161MP0003866_abnormal_defecation0.42745659
162MP0001963_abnormal_hearing_physiology0.42489034
163MP0000613_abnormal_salivary_gland0.41650047
164MP0003315_abnormal_perineum_morphology0.40185688
165MP0001270_distended_abdomen0.39980611
166MP0002557_abnormal_social/conspecific_i0.39866381
167MP0009250_abnormal_appendicular_skeleto0.39118379
168MP0002063_abnormal_learning/memory/cond0.38757252
169MP0000653_abnormal_sex_gland0.38172690
170MP0005220_abnormal_exocrine_pancreas0.37400285

Predicted human phenotypes

RankGene SetZ-score
1Decreased electroretinogram (ERG) amplitude (HP:0000654)9.31872118
2Choroideremia (HP:0001139)7.55371119
3Bony spicule pigmentary retinopathy (HP:0007737)6.48595459
4Scotoma (HP:0000575)6.12503747
5Bilateral sensorineural hearing impairment (HP:0008619)5.37574798
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.11967742
7Ulnar claw (HP:0001178)4.67486635
8Chromsome breakage (HP:0040012)4.58593600
9Hyperventilation (HP:0002883)4.36651771
10Macular degeneration (HP:0000608)4.34164962
11Dyschromatopsia (HP:0007641)4.12826705
12Concave nail (HP:0001598)3.99984542
13Retrobulbar optic neuritis (HP:0100654)3.93377917
14Optic neuritis (HP:0100653)3.93377917
15Abnormality of macular pigmentation (HP:0008002)3.78500187
16Hemiparesis (HP:0001269)3.76248062
17Action tremor (HP:0002345)3.74906941
18Central scotoma (HP:0000603)3.74849776
19Pigmentary retinal degeneration (HP:0001146)3.50290723
20Tubular atrophy (HP:0000092)3.48279086
21Recurrent abscess formation (HP:0002722)3.45076476
22Severe visual impairment (HP:0001141)3.25790016
23Abnormal pupillary function (HP:0007686)3.25719993
24Hypopigmentation of the fundus (HP:0007894)3.23367848
25Segmental peripheral demyelination/remyelination (HP:0003481)3.23024652
26Type II diabetes mellitus (HP:0005978)3.14481095
27Abnormal hair whorl (HP:0010721)3.12248792
28Orchitis (HP:0100796)3.09308974
29Hypoplasia of the fovea (HP:0007750)3.08461675
30Aplasia/Hypoplasia of the fovea (HP:0008060)3.08461675
31Prostate neoplasm (HP:0100787)3.06428555
32Recurrent bacterial skin infections (HP:0005406)3.03283890
33Constricted visual fields (HP:0001133)3.00396216
34Upper limb muscle weakness (HP:0003484)2.91901841
35Termporal pattern (HP:0011008)2.88772709
36Insidious onset (HP:0003587)2.88772709
37Type I transferrin isoform profile (HP:0003642)2.86866096
38Photophobia (HP:0000613)2.85177457
39Gaze-evoked nystagmus (HP:0000640)2.81787028
40Absent eyebrow (HP:0002223)2.81566223
41True hermaphroditism (HP:0010459)2.81435671
42Decreased central vision (HP:0007663)2.80076876
43Abnormality of the renal collecting system (HP:0004742)2.79965196
44Abnormality of the dental pulp (HP:0006479)2.75716359
45Myositis (HP:0100614)2.73325017
46Pancreatic fibrosis (HP:0100732)2.71350253
47Duplicated collecting system (HP:0000081)2.70941672
48Hypothermia (HP:0002045)2.66851239
49Short chin (HP:0000331)2.66131817
50White forelock (HP:0002211)2.64991412
51Patchy hypopigmentation of hair (HP:0011365)2.64838953
52Abnormality of the fovea (HP:0000493)2.63848452
53Alveolar cell carcinoma (HP:0006519)2.57428540
54Congenital sensorineural hearing impairment (HP:0008527)2.56051836
55Pendular nystagmus (HP:0012043)2.52949532
56Mediastinal lymphadenopathy (HP:0100721)2.52842365
57Ectopic kidney (HP:0000086)2.52347224
58Febrile seizures (HP:0002373)2.51970903
59Clubbing of toes (HP:0100760)2.49169881
60Attenuation of retinal blood vessels (HP:0007843)2.47386397
61Eczematoid dermatitis (HP:0000976)2.43390295
62Focal seizures (HP:0007359)2.42610483
63Tinnitus (HP:0000360)2.42340099
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.42338005
65Type 2 muscle fiber atrophy (HP:0003554)2.39779122
66Abnormality of the preputium (HP:0100587)2.38160163
67Reduced antithrombin III activity (HP:0001976)2.37890279
68Absent speech (HP:0001344)2.37498331
69Meckel diverticulum (HP:0002245)2.35753329
70Keratoconjunctivitis sicca (HP:0001097)2.34319475
71Peripheral hypomyelination (HP:0007182)2.33307581
72Pancreatic cysts (HP:0001737)2.32936532
73Cone-rod dystrophy (HP:0000548)2.32862424
74Abnormality of chromosome stability (HP:0003220)2.32152250
75Congenital stationary night blindness (HP:0007642)2.29968736
76Medial flaring of the eyebrow (HP:0010747)2.28987829
77Postural tremor (HP:0002174)2.27656420
78Relative macrocephaly (HP:0004482)2.27331849
79Abnormality of the ileum (HP:0001549)2.23730650
80Keratoconus (HP:0000563)2.21652937
81Increased corneal curvature (HP:0100692)2.21652937
82Keratoconjunctivitis (HP:0001096)2.19598816
83Recurrent pneumonia (HP:0006532)2.19343253
84Renal cortical cysts (HP:0000803)2.18761557
85Abolished electroretinogram (ERG) (HP:0000550)2.17674468
86Abnormality of the prostate (HP:0008775)2.15869745
87Abnormal rod and cone electroretinograms (HP:0008323)2.13651382
88Neoplasm of the tracheobronchial system (HP:0100552)2.11160469
89Increased IgM level (HP:0003496)2.10758309
90Birth length less than 3rd percentile (HP:0003561)2.07901090
91Abnormality of incisor morphology (HP:0011063)2.06661541
92Agnosia (HP:0010524)2.03626742
93Premature skin wrinkling (HP:0100678)2.02422494
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01452013
95Pulmonary infiltrates (HP:0002113)2.01123735
96Focal motor seizures (HP:0011153)2.00484293
97Preaxial hand polydactyly (HP:0001177)1.99607454
98Nephrogenic diabetes insipidus (HP:0009806)1.98734067
99Abnormality of DNA repair (HP:0003254)1.98032312
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.97772099
101Meningitis (HP:0001287)1.96013313
102Abnormality of macrophages (HP:0004311)1.95936469
103Cerebellar dysplasia (HP:0007033)1.95874674
104Systemic lupus erythematosus (HP:0002725)1.95800982
105Encephalitis (HP:0002383)1.95016044
106Hypergonadotropic hypogonadism (HP:0000815)1.93778444
107Optic nerve hypoplasia (HP:0000609)1.91190457
108Postaxial foot polydactyly (HP:0001830)1.90153510
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88400317
110Abnormality of dentin (HP:0010299)1.87534772
111Hypoplastic nipples (HP:0002557)1.86157169
112Optic disc pallor (HP:0000543)1.85913684
113Type II lissencephaly (HP:0007260)1.85662724
114Gingivitis (HP:0000230)1.84024163
115Stereotypic behavior (HP:0000733)1.83545164
116Rimmed vacuoles (HP:0003805)1.83516774
117Tubulointerstitial nephritis (HP:0001970)1.81908969
118Aortic valve stenosis (HP:0001650)1.81666733
119Recurrent skin infections (HP:0001581)1.81402221
120Abnormality of male internal genitalia (HP:0000022)1.80038319
121Recurrent gram-negative bacterial infections (HP:0005420)1.78697571
122Absent hair (HP:0002298)1.78614170
123Nephronophthisis (HP:0000090)1.78412695
124IgM deficiency (HP:0002850)1.78280440
125Thyroiditis (HP:0100646)1.78111189
126Abnormality of the renal medulla (HP:0100957)1.77252701
127Increased CSF protein (HP:0002922)1.76736494
1283-Methylglutaconic aciduria (HP:0003535)1.76686749
129Recurrent cutaneous fungal infections (HP:0011370)1.76675179
130Chronic mucocutaneous candidiasis (HP:0002728)1.76675179
131Vasculitis (HP:0002633)1.75934029
132Chronic obstructive pulmonary disease (HP:0006510)1.75802117
133Obstructive lung disease (HP:0006536)1.75802117
134Congenital primary aphakia (HP:0007707)1.75458042
135Recurrent lower respiratory tract infections (HP:0002783)1.75175618
136Acanthocytosis (HP:0001927)1.75161413
137Aplasia/Hypoplasia of the macula (HP:0008059)1.74602099
138Osteomalacia (HP:0002749)1.74324897
139Drooling (HP:0002307)1.73943471
140Muscle fiber atrophy (HP:0100295)1.73670654
141Septo-optic dysplasia (HP:0100842)1.72393678
142Generalized hypopigmentation of hair (HP:0011358)1.72026131
143Tubulointerstitial fibrosis (HP:0005576)1.71831821
144Poor coordination (HP:0002370)1.71427550
145Glomerulopathy (HP:0100820)1.71377340
146Inappropriate behavior (HP:0000719)1.70924502
147Abnormality of the renal cortex (HP:0011035)1.69285269
148Median cleft lip (HP:0000161)1.68335775
149Prolonged neonatal jaundice (HP:0006579)1.68205506
150Protruding tongue (HP:0010808)1.66528929
151Keratitis (HP:0000491)1.64906639
152Stomach cancer (HP:0012126)1.64536706
153Neonatal short-limb short stature (HP:0008921)1.64487399
154Small intestinal stenosis (HP:0012848)1.64381515
155Duodenal stenosis (HP:0100867)1.64381515
156Chronic hepatic failure (HP:0100626)1.64370004
157Retinitis pigmentosa (HP:0000510)1.63994823
158Syringomyelia (HP:0003396)1.63593750
159Spinal cord lesions (HP:0100561)1.63593750
160Impaired proprioception (HP:0010831)1.63389404
161Bone marrow hypocellularity (HP:0005528)1.63357408
162Hypoplastic iliac wings (HP:0002866)1.62845624
163Clumsiness (HP:0002312)1.62525092
164Gastroesophageal reflux (HP:0002020)1.59743985
165Mesangial abnormality (HP:0001966)1.59182197
166Increased connective tissue (HP:0009025)1.56412850
167Excessive salivation (HP:0003781)1.55854944
168Small hand (HP:0200055)1.55040895
169Abnormal drinking behavior (HP:0030082)1.54978501
170Polydipsia (HP:0001959)1.54978501
171Fair hair (HP:0002286)1.52744168
172Blue irides (HP:0000635)1.52473208
173Epileptic encephalopathy (HP:0200134)1.51615017
174Broad-based gait (HP:0002136)1.51410606
175Chorioretinal atrophy (HP:0000533)1.50252212
176Enlarged penis (HP:0000040)1.49849654
177Inability to walk (HP:0002540)1.47023970
178Macroorchidism (HP:0000053)1.45693214
179Horizontal nystagmus (HP:0000666)1.44829486
180Macroglossia (HP:0000158)1.44590395
181Conical tooth (HP:0000698)1.42758500
182Aplasia cutis congenita (HP:0001057)1.42727864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.88207651
2CASK3.49325206
3MAP3K143.43888380
4IRAK43.26911211
5ZAK3.24016447
6PLK43.20617207
7IRAK33.12882196
8TXK2.88584171
9MAP3K92.77865080
10BMPR22.62992360
11WNK42.61158271
12ERBB32.49357558
13SIK32.46885412
14YES12.10096325
15PRPF4B2.08431683
16TIE11.86609391
17MAP4K21.86141966
18BRD41.77523666
19MKNK21.75042510
20EEF2K1.74319240
21AKT31.71548836
22EIF2AK21.68348562
23PTK2B1.68241186
24STK38L1.62495423
25LATS21.59252705
26STK241.57325705
27TNIK1.56214639
28JAK31.52318665
29SGK21.50862156
30SRPK11.44114542
31BUB11.41989337
32IKBKB1.41826160
33MKNK11.41268659
34MAP2K71.40597416
35PINK11.39385308
36TEC1.33905707
37NEK61.33590261
38CHUK1.31854005
39NTRK31.30269276
40STK161.28280355
41MAPKAPK31.27823363
42BMPR1B1.23571087
43MAPKAPK51.20936358
44IKBKE1.19380647
45MUSK1.18054299
46GRK11.15481787
47CDK81.14250802
48NLK1.14056210
49STK391.13214052
50STK381.10096828
51ADRBK11.08932602
52LATS11.08569037
53SIK21.08139962
54PLK21.07422272
55MAPK131.06621417
56IRAK11.06480702
57INSRR1.06333371
58IRAK21.05871970
59ADRBK21.03358513
60EIF2AK31.00933068
61PIM20.98866005
62NUAK10.98477721
63VRK10.95816745
64CDK30.94369843
65PIK3CG0.92501814
66PBK0.91394518
67TAOK20.89701389
68KSR20.89159649
69MAP3K60.88898581
70GRK70.88188726
71CAMK1D0.87797512
72MARK10.86142682
73NEK20.85363801
74KIT0.83963873
75NEK90.81111187
76PRKCG0.81009939
77BRAF0.80084071
78MAP3K40.79876842
79TGFBR20.79868331
80CCNB10.79087017
81TRPM70.77847405
82ERBB20.76322814
83WNK30.75661880
84PRKAA20.74478601
85CSNK1D0.72468074
86MAP3K120.71861366
87RIPK40.71784858
88PIM10.70754050
89ATR0.69039321
90EIF2AK10.68231751
91ACVR1B0.68163855
92SGK30.68078671
93LYN0.66140106
94TGFBR10.65853054
95NTRK20.65267908
96BTK0.65048055
97SGK4940.63681903
98SGK2230.63681903
99TAOK30.61832119
100SYK0.61287700
101TNK20.58701683
102TAF10.56800507
103ERBB40.56750236
104CSNK1A1L0.56750040
105FES0.55704131
106CAMK2A0.54922858
107FGFR20.54304682
108CAMK40.54044863
109EPHA30.53584196
110CLK10.53163954
111PLK30.53070417
112MAP2K10.51513180
113MAP3K130.51280691
114EPHA40.50077962
115DAPK20.49476837
116TSSK60.48122058
117CSNK1G10.47604527
118FRK0.47170889
119RPS6KB10.46806977
120ARAF0.46182092
121EPHA20.46089377
122ROCK10.44513005
123STK40.44097838
124STK30.44035564
125TYK20.43947343
126TBK10.43586179
127DYRK20.42921217
128CAMK1G0.42837043
129CSF1R0.40662933
130PNCK0.40182265
131PRKCB0.40114343
132CSNK1G30.39693260
133OBSCN0.39436835
134CAMK2D0.39274205
135MAPK70.39254691
136RPS6KB20.38463609
137NME10.37999923
138PRKCD0.37646931
139RAF10.37546249
140PRKACG0.37371769
141BLK0.36885481
142PLK10.36728246
143MST40.36655484
144PRKCE0.36466946
145MYLK0.36225194
146PAK30.34897680
147PRKAA10.34876761
148CSNK2A10.34835453
149CHEK20.34817669
150SGK10.34786091
151TTK0.34753032
152PRKACA0.34326535
153CDK50.33587680
154JAK10.33128395
155MST1R0.32426584
156HCK0.30537076
157CSNK1G20.30415034
158BCR0.30237704
159RPS6KA60.29098864
160MARK30.28189145
161MAP3K10.27654637
162PIK3CA0.26560085
163DYRK1A0.26041202

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.42576417
2Caffeine metabolism_Homo sapiens_hsa002323.30904846
3Linoleic acid metabolism_Homo sapiens_hsa005913.29912330
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.88708710
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81784676
6Fanconi anemia pathway_Homo sapiens_hsa034602.79965401
7Homologous recombination_Homo sapiens_hsa034402.45730052
8Tryptophan metabolism_Homo sapiens_hsa003802.45632068
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.43919255
10Allograft rejection_Homo sapiens_hsa053302.37814371
11Graft-versus-host disease_Homo sapiens_hsa053322.36037512
12RNA polymerase_Homo sapiens_hsa030202.25596418
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.15550746
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07722077
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03517834
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00530538
17Mismatch repair_Homo sapiens_hsa034301.88084227
18Phototransduction_Homo sapiens_hsa047441.81293564
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80099740
20Autoimmune thyroid disease_Homo sapiens_hsa053201.78180384
21Measles_Homo sapiens_hsa051621.74566964
22Fatty acid biosynthesis_Homo sapiens_hsa000611.73578487
23Rheumatoid arthritis_Homo sapiens_hsa053231.73554947
24Leishmaniasis_Homo sapiens_hsa051401.72299771
25Type I diabetes mellitus_Homo sapiens_hsa049401.71799526
26Basal transcription factors_Homo sapiens_hsa030221.70759350
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69326244
28Legionellosis_Homo sapiens_hsa051341.69079984
29DNA replication_Homo sapiens_hsa030301.68405360
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67275950
31Base excision repair_Homo sapiens_hsa034101.66928334
32Salivary secretion_Homo sapiens_hsa049701.59571191
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59207891
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58700638
35Proteasome_Homo sapiens_hsa030501.57604771
36Asthma_Homo sapiens_hsa053101.53866034
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52750254
38Glutamatergic synapse_Homo sapiens_hsa047241.46746726
39Dorso-ventral axis formation_Homo sapiens_hsa043201.46076535
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.45917857
41Pyrimidine metabolism_Homo sapiens_hsa002401.44535274
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44420354
43Herpes simplex infection_Homo sapiens_hsa051681.43101257
44One carbon pool by folate_Homo sapiens_hsa006701.40103249
45Other glycan degradation_Homo sapiens_hsa005111.39415469
46GABAergic synapse_Homo sapiens_hsa047271.37575801
47Nitrogen metabolism_Homo sapiens_hsa009101.34916821
48Hematopoietic cell lineage_Homo sapiens_hsa046401.32721116
49Non-homologous end-joining_Homo sapiens_hsa034501.30156886
50Arachidonic acid metabolism_Homo sapiens_hsa005901.29928978
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28011657
52Circadian entrainment_Homo sapiens_hsa047131.27741696
53Regulation of autophagy_Homo sapiens_hsa041401.27329653
54Influenza A_Homo sapiens_hsa051641.24860293
55Staphylococcus aureus infection_Homo sapiens_hsa051501.22427564
56Bile secretion_Homo sapiens_hsa049761.21779057
57Butanoate metabolism_Homo sapiens_hsa006501.21773786
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21384962
59Nucleotide excision repair_Homo sapiens_hsa034201.18571743
60Primary immunodeficiency_Homo sapiens_hsa053401.18062537
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17786270
62Purine metabolism_Homo sapiens_hsa002301.17081373
63Sulfur relay system_Homo sapiens_hsa041221.10518042
64Malaria_Homo sapiens_hsa051441.09830625
65Calcium signaling pathway_Homo sapiens_hsa040201.09640050
66Tuberculosis_Homo sapiens_hsa051521.09409550
67Morphine addiction_Homo sapiens_hsa050321.06225723
68RNA degradation_Homo sapiens_hsa030181.04913952
69Protein export_Homo sapiens_hsa030601.04757380
70Phagosome_Homo sapiens_hsa041451.00456043
71Long-term depression_Homo sapiens_hsa047300.99444736
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.98348036
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97119726
74TNF signaling pathway_Homo sapiens_hsa046680.95845428
75Pertussis_Homo sapiens_hsa051330.94566308
76Mineral absorption_Homo sapiens_hsa049780.94021476
77Complement and coagulation cascades_Homo sapiens_hsa046100.93160508
78Chemical carcinogenesis_Homo sapiens_hsa052040.92494171
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90970593
80Cocaine addiction_Homo sapiens_hsa050300.90370141
81Nicotine addiction_Homo sapiens_hsa050330.87947483
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85499073
83Cell cycle_Homo sapiens_hsa041100.85092414
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83381060
85Epstein-Barr virus infection_Homo sapiens_hsa051690.79081833
86Osteoclast differentiation_Homo sapiens_hsa043800.77948001
87Insulin secretion_Homo sapiens_hsa049110.77204066
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76940604
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75987021
90African trypanosomiasis_Homo sapiens_hsa051430.75784600
91Renin secretion_Homo sapiens_hsa049240.75561701
92ABC transporters_Homo sapiens_hsa020100.75469498
93Lysine degradation_Homo sapiens_hsa003100.74909980
94cAMP signaling pathway_Homo sapiens_hsa040240.74794054
95Chemokine signaling pathway_Homo sapiens_hsa040620.71926403
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71878707
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70268987
98Oxytocin signaling pathway_Homo sapiens_hsa049210.69932048
99Gastric acid secretion_Homo sapiens_hsa049710.68248079
100Basal cell carcinoma_Homo sapiens_hsa052170.67842187
101p53 signaling pathway_Homo sapiens_hsa041150.67729650
102Apoptosis_Homo sapiens_hsa042100.67204196
103Spliceosome_Homo sapiens_hsa030400.67162064
104Sphingolipid metabolism_Homo sapiens_hsa006000.66343710
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.65689093
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.65151219
107Cardiac muscle contraction_Homo sapiens_hsa042600.64780454
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64365834
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63368199
110Thyroid hormone synthesis_Homo sapiens_hsa049180.61282744
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59815243
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59240044
113Salmonella infection_Homo sapiens_hsa051320.58939749
114Fatty acid degradation_Homo sapiens_hsa000710.58670797
115Retinol metabolism_Homo sapiens_hsa008300.57747167
116Vitamin digestion and absorption_Homo sapiens_hsa049770.57588082
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56704803
118Toxoplasmosis_Homo sapiens_hsa051450.56533248
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55563860
120Hepatitis B_Homo sapiens_hsa051610.55256544
121Dilated cardiomyopathy_Homo sapiens_hsa054140.55044408
122Dopaminergic synapse_Homo sapiens_hsa047280.54429767
123Histidine metabolism_Homo sapiens_hsa003400.53979935
124Glutathione metabolism_Homo sapiens_hsa004800.52047077
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50059163
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47314310
127Circadian rhythm_Homo sapiens_hsa047100.47074439
128Hepatitis C_Homo sapiens_hsa051600.46499868
129Arginine and proline metabolism_Homo sapiens_hsa003300.45997391
130Wnt signaling pathway_Homo sapiens_hsa043100.45809477
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45442338
132Vitamin B6 metabolism_Homo sapiens_hsa007500.45131653
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.44851903
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44343198
135Amphetamine addiction_Homo sapiens_hsa050310.44100611
136Serotonergic synapse_Homo sapiens_hsa047260.43431179
137Olfactory transduction_Homo sapiens_hsa047400.42279238
138Collecting duct acid secretion_Homo sapiens_hsa049660.41938058
139Ovarian steroidogenesis_Homo sapiens_hsa049130.41265580
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40759542
141Fat digestion and absorption_Homo sapiens_hsa049750.39530068
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39301253
143Ether lipid metabolism_Homo sapiens_hsa005650.38498252
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38005039
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37892656
146Shigellosis_Homo sapiens_hsa051310.37037794
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35504372
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35390855
149Antigen processing and presentation_Homo sapiens_hsa046120.34907931
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34834240
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34590842
152Fatty acid metabolism_Homo sapiens_hsa012120.34151262
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33376121
154Peroxisome_Homo sapiens_hsa041460.32949513
155TGF-beta signaling pathway_Homo sapiens_hsa043500.32820590
156Pancreatic secretion_Homo sapiens_hsa049720.32416877
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32356288
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.31465710
159Ras signaling pathway_Homo sapiens_hsa040140.31218975
160Oocyte meiosis_Homo sapiens_hsa041140.30893623
161HTLV-I infection_Homo sapiens_hsa051660.30195673
162Steroid biosynthesis_Homo sapiens_hsa001000.29785250
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29592392
164Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29440499
165Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28605684
166Taste transduction_Homo sapiens_hsa047420.27494220
167Metabolic pathways_Homo sapiens_hsa011000.26854001
168Cholinergic synapse_Homo sapiens_hsa047250.26511181
169Lysosome_Homo sapiens_hsa041420.26502609
170Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26277571
171Hippo signaling pathway_Homo sapiens_hsa043900.26157248
172Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25741398
173Notch signaling pathway_Homo sapiens_hsa043300.25138286
174FoxO signaling pathway_Homo sapiens_hsa040680.24913055

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