ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in sensory perception (GO:0050962)	5.42651981
2	detection of light stimulus involved in visual perception (GO:0050908)	5.42651981
3	postsynaptic membrane organization (GO:0001941)	5.38559391
4	presynaptic membrane assembly (GO:0097105)	5.33173970
5	neuron fate determination (GO:0048664)	4.84484842
6	regulation of cilium movement (GO:0003352)	4.68263435
7	protein K6-linked ubiquitination (GO:0085020)	4.51827441
8	protein-cofactor linkage (GO:0018065)	4.38509477
9	presynaptic membrane organization (GO:0097090)	4.33322613
10	chaperone-mediated protein transport (GO:0072321)	4.27209017
11	DNA damage response, detection of DNA damage (GO:0042769)	4.16468313
12	neuron cell-cell adhesion (GO:0007158)	4.05546549
13	auditory behavior (GO:0031223)	3.96535191
14	behavioral response to nicotine (GO:0035095)	3.95032116
15	negative regulation of cell aging (GO:0090344)	3.93366393
16	pyrimidine dimer repair (GO:0006290)	3.76864919
17	response to auditory stimulus (GO:0010996)	3.75996448
18	protein-chromophore linkage (GO:0018298)	3.71666351
19	cell proliferation in forebrain (GO:0021846)	3.66620880
20	regulation of female receptivity (GO:0045924)	3.62764958
21	amine catabolic process (GO:0009310)	3.62499555
22	cellular biogenic amine catabolic process (GO:0042402)	3.62499555
23	axonal fasciculation (GO:0007413)	3.56548357
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.46300907
25	neurotransmitter-gated ion channel clustering (GO:0072578)	3.43020483
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.41861937
27	positive regulation of mitochondrial fission (GO:0090141)	3.27828296
28	lysine catabolic process (GO:0006554)	3.26442149
29	lysine metabolic process (GO:0006553)	3.26442149
30	vocalization behavior (GO:0071625)	3.24674730
31	transepithelial transport (GO:0070633)	3.23023080
32	folic acid metabolic process (GO:0046655)	3.22610937
33	sequestering of actin monomers (GO:0042989)	3.21200811
34	sodium-independent organic anion transport (GO:0043252)	3.18433496
35	female mating behavior (GO:0060180)	3.18001076
36	retinal cone cell development (GO:0046549)	3.13121866
37	mechanosensory behavior (GO:0007638)	3.09555175
38	regulation of DNA-templated transcription, initiation (GO:2000142)	3.09315479
39	regulation of microtubule-based movement (GO:0060632)	3.09231580
40	dendritic spine morphogenesis (GO:0060997)	3.06535127
41	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.06037610
42	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.06037610
43	regulation of translation, ncRNA-mediated (GO:0045974)	3.06037610
44	replication fork processing (GO:0031297)	3.04531720
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.03676285
46	ncRNA catabolic process (GO:0034661)	3.02860965
47	aspartate family amino acid catabolic process (GO:0009068)	3.01064493
48	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	2.98811943
49	histone H3-K4 trimethylation (GO:0080182)	2.97531527
50	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.97482525
51	retinal ganglion cell axon guidance (GO:0031290)	2.95231146
52	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.93997425
53	inner mitochondrial membrane organization (GO:0007007)	2.93263175
54	DNA strand elongation (GO:0022616)	2.91449808
55	spinal cord association neuron differentiation (GO:0021527)	2.90471018
56	establishment of integrated proviral latency (GO:0075713)	2.87413846
57	L-methionine salvage (GO:0071267)	2.85878215
58	L-methionine biosynthetic process (GO:0071265)	2.85878215
59	amino acid salvage (GO:0043102)	2.85878215
60	nucleobase catabolic process (GO:0046113)	2.81324415
61	nonmotile primary cilium assembly (GO:0035058)	2.81267072
62	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81221674
63	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.80897142
64	negative regulation of response to food (GO:0032096)	2.78235966
65	negative regulation of appetite (GO:0032099)	2.78235966
66	DNA strand renaturation (GO:0000733)	2.78061283
67	positive regulation of synapse assembly (GO:0051965)	2.77542693
68	gamma-aminobutyric acid transport (GO:0015812)	2.75383165
69	tryptophan catabolic process (GO:0006569)	2.71559340
70	indole-containing compound catabolic process (GO:0042436)	2.71559340
71	indolalkylamine catabolic process (GO:0046218)	2.71559340
72	estrogen biosynthetic process (GO:0006703)	2.69847307
73	DNA strand elongation involved in DNA replication (GO:0006271)	2.69172189
74	hematopoietic stem cell proliferation (GO:0071425)	2.67110538
75	translational termination (GO:0006415)	2.65963075
76	photoreceptor cell development (GO:0042461)	2.65426350
77	methionine biosynthetic process (GO:0009086)	2.64670052
78	cranial nerve morphogenesis (GO:0021602)	2.63415318
79	kinetochore assembly (GO:0051382)	2.63389264
80	forebrain neuron differentiation (GO:0021879)	2.62775126
81	tongue development (GO:0043586)	2.61628540
82	cilium morphogenesis (GO:0060271)	2.59770139
83	S-adenosylmethionine metabolic process (GO:0046500)	2.59647427
84	negative regulation of DNA binding (GO:0043392)	2.58435577
85	tetrahydrofolate metabolic process (GO:0046653)	2.58145607
86	rRNA catabolic process (GO:0016075)	2.57694821
87	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.53065142
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.52693480
89	viral transcription (GO:0019083)	2.51850846
90	polyamine metabolic process (GO:0006595)	2.51007467
91	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.47310736
92	hepatocyte differentiation (GO:0070365)	2.46387547
93	neuron recognition (GO:0008038)	2.45912879
94	protein heterotetramerization (GO:0051290)	2.45222910
95	neuronal action potential (GO:0019228)	2.43915009
96	brain morphogenesis (GO:0048854)	2.40587197
97	neuronal stem cell maintenance (GO:0097150)	2.40381086
98	neural tube formation (GO:0001841)	2.40314668
99	regulation of DNA endoreduplication (GO:0032875)	2.39237439
100	sulfation (GO:0051923)	2.39043276

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.37275317
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.96809182
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.48543538
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.38945166
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17947792
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.76746220
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71387710
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56926846
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.55509527
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.32591131
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.27735158
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.00283933
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.99838776
14	EWS_26573619_Chip-Seq_HEK293_Human	1.87318288
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.86197740
16	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.79251296
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.70289227
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70254592
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.70254592
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.70009804
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68606878
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68314770
23	FUS_26573619_Chip-Seq_HEK293_Human	1.66888492
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66783801
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64133357
26	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.63033284
27	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61749140
28	VDR_22108803_ChIP-Seq_LS180_Human	1.60118593
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.58471207
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54426118
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51300121
32	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.48698415
33	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.48138621
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43662040
35	P300_19829295_ChIP-Seq_ESCs_Human	1.42310432
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41810414
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38766493
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38141062
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36711870
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35942119
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.35132233
42	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34501105
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33144754
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31763283
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.31439714
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31050146
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30753278
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28176974
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26934322
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26223179
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22584920
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22559345
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19686923
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.19269121
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19195282
56	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.17713490
57	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14473570
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.12194142
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11600239
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11395380
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.11197933
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10813599
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10743623
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10102802
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.09901020
66	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09719437
67	E2F7_22180533_ChIP-Seq_HELA_Human	1.09650443
68	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08300804
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08142296
70	RXR_22108803_ChIP-Seq_LS180_Human	1.07854433
71	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.07270297
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07184339
73	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06832538
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06685117
75	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04837900
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.04387578
77	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03701806
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.03341006
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03341006
80	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02713042
81	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01837383
82	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01724492
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01001652
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.00748366
85	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.00732655
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99788156
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.99684198
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97967710
89	STAT3_23295773_ChIP-Seq_U87_Human	0.97653068
90	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97076386
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.95819696
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.95640382
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94936398
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94454911
95	NCOR_22424771_ChIP-Seq_293T_Human	0.93257950
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.91771327
97	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91152486
98	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90803171
99	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.89810660
100	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.88788600

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	4.30907697
2	MP0010030_abnormal_orbit_morphology	3.85267417
3	MP0008789_abnormal_olfactory_epithelium	3.56784305
4	MP0006292_abnormal_olfactory_placode	3.41412237
5	MP0003136_yellow_coat_color	3.38545760
6	MP0001529_abnormal_vocalization	3.24634936
7	MP0005248_abnormal_Harderian_gland	3.19667323
8	MP0005394_taste/olfaction_phenotype	3.08235929
9	MP0005499_abnormal_olfactory_system	3.08235929
10	MP0003880_abnormal_central_pattern	2.81258453
11	MP0001984_abnormal_olfaction	2.58153966
12	MP0001346_abnormal_lacrimal_gland	2.54333607
13	MP0000049_abnormal_middle_ear	2.34446495
14	MP0002736_abnormal_nociception_after	2.29995779
15	MP0006276_abnormal_autonomic_nervous	2.27840159
16	MP0000566_synostosis	2.24384453
17	MP0004742_abnormal_vestibular_system	2.13624566
18	MP0005253_abnormal_eye_physiology	2.06648111
19	MP0002249_abnormal_larynx_morphology	2.05244152
20	MP0000778_abnormal_nervous_system	2.02363069
21	MP0001968_abnormal_touch/_nociception	1.99973045
22	MP0003011_delayed_dark_adaptation	1.88034524
23	MP0000026_abnormal_inner_ear	1.77190876
24	MP0000647_abnormal_sebaceous_gland	1.72357128
25	MP0002822_catalepsy	1.71381555
26	MP0004147_increased_porphyrin_level	1.64588175
27	MP0000631_abnormal_neuroendocrine_gland	1.61881083
28	MP0005551_abnormal_eye_electrophysiolog	1.61162263
29	MP0002234_abnormal_pharynx_morphology	1.59876574
30	MP0003890_abnormal_embryonic-extraembry	1.52819797
31	MP0001485_abnormal_pinna_reflex	1.48967713
32	MP0002735_abnormal_chemical_nociception	1.46483663
33	MP0004885_abnormal_endolymph	1.43427555
34	MP0009379_abnormal_foot_pigmentation	1.41792281
35	MP0002098_abnormal_vibrissa_morphology	1.40604052
36	MP0003938_abnormal_ear_development	1.39680440
37	MP0001502_abnormal_circadian_rhythm	1.39189893
38	MP0001293_anophthalmia	1.35906588
39	MP0008875_abnormal_xenobiotic_pharmacok	1.35806319
40	MP0002928_abnormal_bile_duct	1.35270118
41	MP0003879_abnormal_hair_cell	1.34311420
42	MP0005391_vision/eye_phenotype	1.33617548
43	MP0008058_abnormal_DNA_repair	1.33356182
44	MP0002938_white_spotting	1.31059605
45	MP0001963_abnormal_hearing_physiology	1.27377259
46	MP0005171_absent_coat_pigmentation	1.26480567
47	MP0008877_abnormal_DNA_methylation	1.25451386
48	MP0006072_abnormal_retinal_apoptosis	1.24579344
49	MP0004142_abnormal_muscle_tone	1.24248741
50	MP0005423_abnormal_somatic_nervous	1.23900751
51	MP0005195_abnormal_posterior_eye	1.22201783
52	MP0005408_hypopigmentation	1.21508254
53	MP0001270_distended_abdomen	1.20538872
54	MP0002557_abnormal_social/conspecific_i	1.19804536
55	MP0002233_abnormal_nose_morphology	1.18186918
56	MP0000579_abnormal_nail_morphology	1.17404815
57	MP0000569_abnormal_digit_pigmentation	1.11379188
58	MP0003137_abnormal_impulse_conducting	1.10182964
59	MP0000372_irregular_coat_pigmentation	1.09501873
60	MP0004133_heterotaxia	1.07677235
61	MP0001286_abnormal_eye_development	1.06754407
62	MP0002277_abnormal_respiratory_mucosa	1.06597741
63	MP0005084_abnormal_gallbladder_morpholo	1.05332169
64	MP0002752_abnormal_somatic_nervous	1.05133546
65	MP0003122_maternal_imprinting	1.01126656
66	MP0003861_abnormal_nervous_system	0.99585982
67	MP0002272_abnormal_nervous_system	0.99426227
68	MP0008057_abnormal_DNA_replication	0.96403322
69	MP0000427_abnormal_hair_cycle	0.96073437
70	MP0002102_abnormal_ear_morphology	0.96006159
71	MP0009697_abnormal_copulation	0.95904740
72	MP0001486_abnormal_startle_reflex	0.95624682
73	MP0002067_abnormal_sensory_capabilities	0.95556231
74	MP0003755_abnormal_palate_morphology	0.94926680
75	MP0000383_abnormal_hair_follicle	0.94479887
76	MP0003787_abnormal_imprinting	0.90961109
77	MP0002697_abnormal_eye_size	0.90159862
78	MP0001324_abnormal_eye_pigmentation	0.90005339
79	MP0009745_abnormal_behavioral_response	0.85643457
80	MP0002734_abnormal_mechanical_nocicepti	0.82905616
81	MP0002572_abnormal_emotion/affect_behav	0.80916510
82	MP0002064_seizures	0.79703672
83	MP0003119_abnormal_digestive_system	0.79693202
84	MP0009053_abnormal_anal_canal	0.77959251
85	MP0003937_abnormal_limbs/digits/tail_de	0.77831749
86	MP0009250_abnormal_appendicular_skeleto	0.76756515
87	MP0010094_abnormal_chromosome_stability	0.76677790
88	MP0003635_abnormal_synaptic_transmissio	0.76395918
89	MP0003121_genomic_imprinting	0.76113927
90	MP0001764_abnormal_homeostasis	0.75635735
91	MP0001661_extended_life_span	0.74580162
92	MP0002116_abnormal_craniofacial_bone	0.73179431
93	MP0002152_abnormal_brain_morphology	0.72813950
94	MP0002882_abnormal_neuron_morphology	0.72647770
95	MP0002092_abnormal_eye_morphology	0.71920552
96	MP0006035_abnormal_mitochondrial_morpho	0.69455915
97	MP0003115_abnormal_respiratory_system	0.68585170
98	MP0005646_abnormal_pituitary_gland	0.66165300
99	MP0002111_abnormal_tail_morphology	0.65827716
100	MP0001986_abnormal_taste_sensitivity	0.61159390

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of abdominal situs (HP:0011620)	4.91124161
2	Abdominal situs inversus (HP:0003363)	4.91124161
3	Concave nail (HP:0001598)	4.17805110
4	Nephrogenic diabetes insipidus (HP:0009806)	3.64807830
5	Rib fusion (HP:0000902)	3.46070596
6	Gait imbalance (HP:0002141)	3.34521305
7	Congenital stationary night blindness (HP:0007642)	3.31167974
8	Increased hepatocellular lipid droplets (HP:0006565)	3.29911987
9	Congenital primary aphakia (HP:0007707)	3.29223328
10	Abnormal number of erythroid precursors (HP:0012131)	3.21059793
11	True hermaphroditism (HP:0010459)	3.16622229
12	Abnormality of the pons (HP:0007361)	3.15333965
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.07982596
14	Increased intramyocellular lipid droplets (HP:0012240)	3.06545145
15	Abnormality of the aortic arch (HP:0012303)	2.89479765
16	Cerebral hypomyelination (HP:0006808)	2.85100714
17	Medial flaring of the eyebrow (HP:0010747)	2.84305946
18	Neonatal respiratory distress (HP:0002643)	2.83752363
19	Lipid accumulation in hepatocytes (HP:0006561)	2.78694824
20	Hypoplasia of the pons (HP:0012110)	2.78502672
21	Conjugated hyperbilirubinemia (HP:0002908)	2.78130099
22	Mitochondrial inheritance (HP:0001427)	2.76450683
23	Hyperventilation (HP:0002883)	2.75554937
24	Retinal dysplasia (HP:0007973)	2.74322904
25	Renal hypoplasia (HP:0000089)	2.72823157
26	Oligodactyly (HP:0012165)	2.67470160
27	Renal Fanconi syndrome (HP:0001994)	2.64752568
28	Hepatocellular necrosis (HP:0001404)	2.58786821
29	Chorioretinal atrophy (HP:0000533)	2.58675735
30	Pancreatic fibrosis (HP:0100732)	2.58502425
31	Patellar aplasia (HP:0006443)	2.57834766
32	Molar tooth sign on MRI (HP:0002419)	2.56786929
33	Abnormality of midbrain morphology (HP:0002418)	2.56786929
34	Decreased central vision (HP:0007663)	2.53816518
35	Pancreatic cysts (HP:0001737)	2.53615043
36	Split foot (HP:0001839)	2.47964183
37	Aplasia/Hypoplasia of the patella (HP:0006498)	2.46839277
38	Respiratory difficulties (HP:0002880)	2.44413098
39	Genital tract atresia (HP:0001827)	2.42970283
40	Cortical dysplasia (HP:0002539)	2.39988189
41	Transposition of the great arteries (HP:0001669)	2.39967425
42	Abnormal connection of the cardiac segments (HP:0011545)	2.39967425
43	Abnormal ventriculo-arterial connection (HP:0011563)	2.39967425
44	Rectal fistula (HP:0100590)	2.35535230
45	Rectovaginal fistula (HP:0000143)	2.35535230
46	Increased CSF lactate (HP:0002490)	2.34941663
47	Vaginal atresia (HP:0000148)	2.34054685
48	Increased muscle lipid content (HP:0009058)	2.31326501
49	Mesangial abnormality (HP:0001966)	2.29884881
50	Attenuation of retinal blood vessels (HP:0007843)	2.28476865
51	Aplasia/Hypoplasia of the lens (HP:0008063)	2.28276042
52	Postaxial foot polydactyly (HP:0001830)	2.26598274
53	Large for gestational age (HP:0001520)	2.25347158
54	Anterior segment dysgenesis (HP:0007700)	2.23297857
55	Oligodactyly (hands) (HP:0001180)	2.22117317
56	Congenital, generalized hypertrichosis (HP:0004540)	2.21230681
57	Hyperglycinemia (HP:0002154)	2.19003851
58	Poor coordination (HP:0002370)	2.17376138
59	Facial hemangioma (HP:0000329)	2.14749722
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13795950
61	Prolonged neonatal jaundice (HP:0006579)	2.13456654
62	Abnormality of the diencephalon (HP:0010662)	2.09447070
63	Broad metatarsal (HP:0001783)	2.07938775
64	Abnormality of DNA repair (HP:0003254)	2.07663321
65	Exertional dyspnea (HP:0002875)	2.07490478
66	Intestinal atresia (HP:0011100)	2.05800255
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01769766
68	Hepatic necrosis (HP:0002605)	2.01344536
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98850037
70	Hip dysplasia (HP:0001385)	1.95970576
71	Specific learning disability (HP:0001328)	1.95155479
72	Intestinal fistula (HP:0100819)	1.94766131
73	Anencephaly (HP:0002323)	1.92485076
74	Renal dysplasia (HP:0000110)	1.88811957
75	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.88671380
76	Hypoplasia of the brainstem (HP:0002365)	1.88671380
77	Renal tubular dysfunction (HP:0000124)	1.87298825
78	Vaginal fistula (HP:0004320)	1.86238408
79	Acute necrotizing encephalopathy (HP:0006965)	1.86066518
80	Poikiloderma (HP:0001029)	1.85880015
81	Astigmatism (HP:0000483)	1.85311599
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82284398
83	Anophthalmia (HP:0000528)	1.81415196
84	Annular pancreas (HP:0001734)	1.80511822
85	Generalized myoclonic seizures (HP:0002123)	1.80167089
86	Broad-based gait (HP:0002136)	1.79832864
87	Abnormality of the renal medulla (HP:0100957)	1.79720139
88	Chronic hepatic failure (HP:0100626)	1.79066365
89	Hypoplasia of the ulna (HP:0003022)	1.78794447
90	Neoplasm of the adrenal cortex (HP:0100641)	1.78423167
91	Testicular atrophy (HP:0000029)	1.77945517
92	Hyperphosphaturia (HP:0003109)	1.77192410
93	Abnormality of renal resorption (HP:0011038)	1.76986622
94	Polyphagia (HP:0002591)	1.76325768
95	Septo-optic dysplasia (HP:0100842)	1.74309416
96	Postaxial hand polydactyly (HP:0001162)	1.73708365
97	Gastrointestinal atresia (HP:0002589)	1.70992444
98	Severe Myopia (HP:0011003)	1.68746675
99	Hemivertebrae (HP:0002937)	1.67620139
100	Esophageal atresia (HP:0002032)	1.66635617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.67311526
2	VRK2	3.98086865
3	WNK3	3.32569818
4	EPHA4	2.88994754
5	CASK	2.70093235
6	FRK	2.69262920
7	PINK1	2.48995548
8	PLK4	2.44508200
9	MAP2K7	2.39616721
10	CDK19	2.39170218
11	STK38L	2.23655568
12	PLK2	2.14113108
13	NTRK2	1.99843856
14	MAP4K2	1.93464891
15	MARK1	1.93259091
16	CDK8	1.73422875
17	DYRK2	1.73270714
18	VRK1	1.71904544
19	BMPR1B	1.66892719
20	DYRK1B	1.66025501
21	DYRK1A	1.55297891
22	ADRBK2	1.54840240
23	CCNB1	1.49356129
24	GRK1	1.48465562
25	OXSR1	1.40537315
26	TAF1	1.39522877
27	BCKDK	1.38520247
28	CSNK1G3	1.38190801
29	CSNK1A1L	1.26331631
30	MAPK15	1.22205795
31	TAOK3	1.18885257
32	ERBB3	1.13853352
33	BRD4	1.12129402
34	PASK	1.10134852
35	PAK3	1.08328245
36	CSNK1G2	1.08278379
37	MAP3K7	1.04357065
38	NUAK1	1.04061151
39	CSNK1G1	0.99590625
40	EPHB2	0.95143352
41	MAPK13	0.94074942
42	TNK2	0.93296573
43	TGFBR1	0.91976111
44	MAP3K4	0.88655582
45	KSR1	0.87784497
46	AKT3	0.83672385
47	SRPK1	0.80629054
48	INSRR	0.78545269
49	GRK5	0.78044112
50	DAPK2	0.76048780
51	CDK14	0.74900636
52	SMG1	0.74743458
53	FGFR2	0.72431575
54	CDK15	0.71326650
55	ADRBK1	0.69564572
56	CDK3	0.69341384
57	CDK11A	0.67957838
58	CDK18	0.66731226
59	DAPK3	0.63680149
60	STK11	0.63527144
61	PRKCG	0.63145972
62	TESK2	0.62469851
63	CHEK2	0.62440256
64	PIM2	0.62211088
65	PRKAA1	0.61000631
66	PLK1	0.58743265
67	CDK9	0.57928992
68	ZAK	0.57663445
69	MAPKAPK5	0.57577413
70	ATR	0.57270730
71	BCR	0.55614587
72	TYK2	0.55392934
73	PDK2	0.55000494
74	STK38	0.54910829
75	MKNK2	0.54134199
76	SGK223	0.53564518
77	SGK494	0.53564518
78	LRRK2	0.49915924
79	PLK3	0.49717275
80	OBSCN	0.48712580
81	AURKA	0.48683406
82	CSNK1E	0.47739746
83	TNIK	0.45869673
84	MAP3K6	0.45524369
85	MAP2K4	0.45103555
86	NME1	0.44616803
87	CSNK1D	0.43818722
88	CSNK1A1	0.43757103
89	PRKACA	0.43144799
90	UHMK1	0.41338962
91	CDK5	0.39204103
92	MKNK1	0.38608677
93	CAMK4	0.38602145
94	CSNK2A1	0.37529043
95	MELK	0.37178472
96	EIF2AK2	0.35672291
97	WNK4	0.35603361
98	CSNK2A2	0.35491343
99	PRKD3	0.35336019
100	BUB1	0.34298611

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.69301867
2	One carbon pool by folate_Homo sapiens_hsa00670	3.10366262
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93452472
4	Ribosome_Homo sapiens_hsa03010	2.69008078
5	Protein export_Homo sapiens_hsa03060	2.67318717
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34260734
7	RNA polymerase_Homo sapiens_hsa03020	2.25519377
8	Parkinsons disease_Homo sapiens_hsa05012	2.21038510
9	Mismatch repair_Homo sapiens_hsa03430	2.08469410
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.93037448
11	DNA replication_Homo sapiens_hsa03030	1.92252912
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.91441451
13	Nicotine addiction_Homo sapiens_hsa05033	1.80793853
14	Base excision repair_Homo sapiens_hsa03410	1.78637566
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.78170216
16	Homologous recombination_Homo sapiens_hsa03440	1.77649394
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76069861
18	Phototransduction_Homo sapiens_hsa04744	1.73873350
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73547526
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70928616
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.68965631
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.65296905
23	Huntingtons disease_Homo sapiens_hsa05016	1.65190027
24	Taste transduction_Homo sapiens_hsa04742	1.59407183
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.55014555
26	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.54643262
27	Circadian rhythm_Homo sapiens_hsa04710	1.52681078
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48970804
29	Alzheimers disease_Homo sapiens_hsa05010	1.48563679
30	Butanoate metabolism_Homo sapiens_hsa00650	1.45970157
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.42972516
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.38820329
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33232841
34	Arginine and proline metabolism_Homo sapiens_hsa00330	1.31400129
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.31203304
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25301180
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20309481
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19875880
39	Proteasome_Homo sapiens_hsa03050	1.18857866
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.18519611
41	GABAergic synapse_Homo sapiens_hsa04727	1.16825987
42	Lysine degradation_Homo sapiens_hsa00310	1.15179428
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15110645
44	RNA degradation_Homo sapiens_hsa03018	1.13913712
45	Basal transcription factors_Homo sapiens_hsa03022	1.11669905
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10678476
47	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.10091220
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07878299
49	Glutathione metabolism_Homo sapiens_hsa00480	1.04760164
50	Spliceosome_Homo sapiens_hsa03040	1.02164143
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01592460
52	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01062488
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99897964
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98265800
55	Histidine metabolism_Homo sapiens_hsa00340	0.96751351
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94881542
57	Caffeine metabolism_Homo sapiens_hsa00232	0.91338934
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91140841
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.90607444
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89061094
61	Purine metabolism_Homo sapiens_hsa00230	0.86121919
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.83805591
63	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80181205
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77113784
65	Regulation of autophagy_Homo sapiens_hsa04140	0.73709699
66	Fatty acid degradation_Homo sapiens_hsa00071	0.72329740
67	Peroxisome_Homo sapiens_hsa04146	0.72200803
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70923606
69	Morphine addiction_Homo sapiens_hsa05032	0.67238670
70	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.66663923
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.66565213
72	Metabolic pathways_Homo sapiens_hsa01100	0.66176822
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64490010
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61359100
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.61146581
76	Axon guidance_Homo sapiens_hsa04360	0.59807871
77	Olfactory transduction_Homo sapiens_hsa04740	0.57307286
78	Circadian entrainment_Homo sapiens_hsa04713	0.54822190
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.53829221
80	Propanoate metabolism_Homo sapiens_hsa00640	0.49345971
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48561889
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.48249826
83	RNA transport_Homo sapiens_hsa03013	0.45759623
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43655462
85	Retinol metabolism_Homo sapiens_hsa00830	0.42211389
86	Alcoholism_Homo sapiens_hsa05034	0.40641898
87	Mineral absorption_Homo sapiens_hsa04978	0.39129217
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38526264
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.38463147
90	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38113080
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.36666634
92	Hippo signaling pathway_Homo sapiens_hsa04390	0.35166678
93	p53 signaling pathway_Homo sapiens_hsa04115	0.32378643
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.31431191
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.29510682
96	Cell cycle_Homo sapiens_hsa04110	0.29288750
97	Fatty acid elongation_Homo sapiens_hsa00062	0.28382391
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27574970
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25363485
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24986325

RRM2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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