RRM2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.80805004
2neutrophil activation involved in immune response (GO:0002283)7.11831546
3blood coagulation, intrinsic pathway (GO:0007597)5.84663418
4regulation of platelet activation (GO:0010543)5.73819625
5adenosine receptor signaling pathway (GO:0001973)5.68002859
6regulation of platelet aggregation (GO:0090330)5.50904640
7negative regulation of norepinephrine secretion (GO:0010700)5.33981164
8platelet aggregation (GO:0070527)5.11691735
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99477874
10fatty acid elongation (GO:0030497)4.93805314
11positive regulation of endothelial cell differentiation (GO:0045603)4.86796790
12leukocyte migration involved in inflammatory response (GO:0002523)4.83678780
13negative regulation of heart rate (GO:0010459)4.74122872
14regulation of integrin-mediated signaling pathway (GO:2001044)4.67689099
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.56995981
16positive regulation of mast cell activation (GO:0033005)4.51562531
17regulation of Golgi to plasma membrane protein transport (GO:0042996)4.50486224
18regulation of integrin activation (GO:0033623)4.43513928
19negative regulation of thymocyte apoptotic process (GO:0070244)4.41677693
20megakaryocyte development (GO:0035855)4.36372959
21polyamine biosynthetic process (GO:0006596)4.32458537
22negative regulation of platelet activation (GO:0010544)4.27328999
23lipoxygenase pathway (GO:0019372)4.23471007
24negative regulation of response to food (GO:0032096)4.18866247
25negative regulation of appetite (GO:0032099)4.18866247
26neutrophil activation (GO:0042119)4.17273000
27purinergic nucleotide receptor signaling pathway (GO:0035590)4.16617460
28negative regulation of homotypic cell-cell adhesion (GO:0034111)4.14000319
29platelet formation (GO:0030220)4.08236916
30negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.08006628
31angiogenesis involved in wound healing (GO:0060055)4.07750697
32pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.05784110
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02575491
34innate immune response in mucosa (GO:0002227)4.01673829
35endothelium development (GO:0003158)3.97091438
36regulation of memory T cell differentiation (GO:0043380)3.94916118
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.84936856
38negative regulation of T-helper cell differentiation (GO:0045623)3.84936856
39platelet degranulation (GO:0002576)3.83391818
40low-density lipoprotein particle remodeling (GO:0034374)3.79183929
41sequestering of actin monomers (GO:0042989)3.71329592
42fusion of sperm to egg plasma membrane (GO:0007342)3.69308961
43microtubule depolymerization (GO:0007019)3.66466460
44autophagic vacuole fusion (GO:0000046)3.64428774
45regulation of lipoprotein metabolic process (GO:0050746)3.63318234
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.58270757
47homotypic cell-cell adhesion (GO:0034109)3.57670514
48positive regulation of cAMP-mediated signaling (GO:0043950)3.52278397
49granulocyte activation (GO:0036230)3.51670800
50positive regulation of Rho protein signal transduction (GO:0035025)3.51051767
51negative regulation of neural precursor cell proliferation (GO:2000178)3.51002769
52negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.45056376
53purinergic receptor signaling pathway (GO:0035587)3.44420476
54positive regulation of hemostasis (GO:1900048)3.40743352
55positive regulation of blood coagulation (GO:0030194)3.40743352
56platelet activation (GO:0030168)3.38529028
57regulation of norepinephrine secretion (GO:0014061)3.36042166
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34119441
59G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.33558560
60regulation of megakaryocyte differentiation (GO:0045652)3.32428587
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31649219
62negative regulation of catecholamine secretion (GO:0033604)3.28919157
63positive regulation of protein homodimerization activity (GO:0090073)3.28764711
64mucosal immune response (GO:0002385)3.27313657
65negative regulation of heart contraction (GO:0045822)3.25422981
66negative regulation of protein localization to cell surface (GO:2000009)3.24858515
67positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.21018127
68phagocytosis, engulfment (GO:0006911)3.20981275
69regulation of MHC class II biosynthetic process (GO:0045346)3.20647955
70positive regulation of macrophage differentiation (GO:0045651)3.20613416
71cyclooxygenase pathway (GO:0019371)3.20305825
72regulation of endothelial cell differentiation (GO:0045601)3.18395567
73mitochondrial calcium ion transport (GO:0006851)3.18090622
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16497843
75regulation of T-helper 1 cell differentiation (GO:0045625)3.14541484
76positive regulation of mast cell degranulation (GO:0043306)3.12983560
77positive regulation of mast cell activation involved in immune response (GO:0033008)3.12983560
78positive regulation of systemic arterial blood pressure (GO:0003084)3.12547383
79long-chain fatty acid biosynthetic process (GO:0042759)3.12096551
80positive regulation of granulocyte differentiation (GO:0030854)3.09977992
81purine-containing compound salvage (GO:0043101)3.06554289
82regulation of homotypic cell-cell adhesion (GO:0034110)3.01631870
83regulation of mast cell activation (GO:0033003)2.99947938
84beta-amyloid metabolic process (GO:0050435)2.99120710
85monoamine transport (GO:0015844)2.98713502
86relaxation of smooth muscle (GO:0044557)2.98083215
87pyrimidine nucleoside catabolic process (GO:0046135)2.96880586
88positive regulation of coagulation (GO:0050820)2.96166544
89cellular biogenic amine biosynthetic process (GO:0042401)2.95863210
90organelle membrane fusion (GO:0090174)2.95202401
91adenosine metabolic process (GO:0046085)2.94602535
92negative regulation of calcium ion transport into cytosol (GO:0010523)2.94329786
93pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.93151076
94dopamine transport (GO:0015872)2.92952363
95negative regulation of T cell apoptotic process (GO:0070233)2.92395035
96vesicle targeting (GO:0006903)2.91620321
97organ or tissue specific immune response (GO:0002251)2.91514139
98regulation of macrophage derived foam cell differentiation (GO:0010743)2.90548723
99antibacterial humoral response (GO:0019731)2.88000971
100protein neddylation (GO:0045116)10.0955689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.96326931
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.73871852
3SCL_19346495_ChIP-Seq_HPC-7_Human4.31099517
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.96658905
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19526176
6GATA1_19941826_ChIP-Seq_K562_Human3.16882352
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.16818360
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.93146367
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80720480
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.59050235
11GATA2_19941826_ChIP-Seq_K562_Human2.55819570
12HTT_18923047_ChIP-ChIP_STHdh_Human2.49579054
13HOXB4_20404135_ChIP-ChIP_EML_Mouse2.37695476
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29417438
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24495079
16SPI1_23127762_ChIP-Seq_K562_Human2.23335576
17TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.19093212
18GATA1_22383799_ChIP-Seq_G1ME_Mouse2.18778757
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.14056727
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.13426899
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07864982
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.07105553
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04729659
24EZH2_22144423_ChIP-Seq_EOC_Human2.01599813
25GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.89662520
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87893355
27GATA1_22025678_ChIP-Seq_K562_Human1.86598409
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84391476
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84378532
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75830393
31E2F7_22180533_ChIP-Seq_HELA_Human1.71917134
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70396683
33SALL4_22934838_ChIP-ChIP_CD34+_Human1.69016556
34EWS_26573619_Chip-Seq_HEK293_Human1.68619742
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.68309491
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63050298
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62018512
38IRF1_19129219_ChIP-ChIP_H3396_Human1.61084482
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60509454
40ETS1_22383799_ChIP-Seq_G1ME_Mouse1.60196227
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59953538
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57584775
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53892980
44VDR_22108803_ChIP-Seq_LS180_Human1.49087863
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47599927
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47317509
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47231158
48TAF15_26573619_Chip-Seq_HEK293_Human1.45386940
49IGF1R_20145208_ChIP-Seq_DFB_Human1.44923263
50GBX2_23144817_ChIP-Seq_PC3_Human1.43525791
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37826620
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.35944288
53GATA1_19941827_ChIP-Seq_MEL86_Mouse1.34551380
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32331945
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28291047
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27632926
57SPI1_23547873_ChIP-Seq_NB4_Human1.26888081
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25396216
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24339440
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22023393
61NCOR1_26117541_ChIP-Seq_K562_Human1.18935200
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16991561
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16597161
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.15464419
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15173672
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.15087389
67MYB_26560356_Chip-Seq_TH2_Human1.14504469
68ELK1_19687146_ChIP-ChIP_HELA_Human1.11762474
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.11341560
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08113474
71GATA3_27048872_Chip-Seq_THYMUS_Human1.06706973
72ERG_20517297_ChIP-Seq_VCAP_Human1.05858054
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05047892
74SPI1_20517297_ChIP-Seq_HL60_Human0.97830280
75UTX_26944678_Chip-Seq_JUKART_Human0.96848248
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96794008
77STAT1_20625510_ChIP-Seq_HELA_Human0.96590493
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96433884
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96422903
80GATA3_21878914_ChIP-Seq_MCF-7_Human0.95875912
81GATA3_26560356_Chip-Seq_TH2_Human0.94661623
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92037211
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89658707
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.89593985
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89567195
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89065549
87AR_20517297_ChIP-Seq_VCAP_Human0.87094705
88SOX2_19829295_ChIP-Seq_ESCs_Human0.86405445
89NANOG_19829295_ChIP-Seq_ESCs_Human0.86405445
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80649812
91NANOG_20526341_ChIP-Seq_ESCs_Human0.80410156
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.79163897
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77431732
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75843524
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75754076
96RBPJ_21746931_ChIP-Seq_IB4_Human0.75749729
97LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75222631
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74834257
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74640338
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73767496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.71094787
2MP0008004_abnormal_stomach_pH5.26524426
3MP0003724_increased_susceptibility_to3.98818518
4MP0000465_gastrointestinal_hemorrhage3.55614866
5MP0001835_abnormal_antigen_presentation2.79124738
6MP0005167_abnormal_blood-brain_barrier2.18075881
7MP0000343_altered_response_to2.14645940
8MP0004510_myositis2.12990701
9MP0009697_abnormal_copulation2.07164442
10MP0005084_abnormal_gallbladder_morpholo2.02035485
11MP0005646_abnormal_pituitary_gland2.00577089
12MP0002736_abnormal_nociception_after1.91608512
13MP0005083_abnormal_biliary_tract1.90820737
14MP0004084_abnormal_cardiac_muscle1.89722154
15MP0000230_abnormal_systemic_arterial1.84942091
16MP0008775_abnormal_heart_ventricle1.76103524
17MP0002132_abnormal_respiratory_system1.74747629
18MP0003566_abnormal_cell_adhesion1.74495808
19MP0005671_abnormal_response_to1.69882358
20MP0002398_abnormal_bone_marrow1.68087399
21MP0005410_abnormal_fertilization1.66799008
22MP0008872_abnormal_physiological_respon1.65468563
23MP0006054_spinal_hemorrhage1.64048289
24MP0006276_abnormal_autonomic_nervous1.60539356
25MP0003303_peritoneal_inflammation1.59771361
26MP0005397_hematopoietic_system_phenotyp1.52053146
27MP0001545_abnormal_hematopoietic_system1.52053146
28MP0001879_abnormal_lymphatic_vessel1.51576846
29MP0003638_abnormal_response/metabolism_1.48652213
30MP0001851_eye_inflammation1.41842990
31MP0010155_abnormal_intestine_physiology1.41363128
32MP0002148_abnormal_hypersensitivity_rea1.40547222
33MP0005000_abnormal_immune_tolerance1.38754360
34MP0009763_increased_sensitivity_to1.35254370
35MP0006036_abnormal_mitochondrial_physio1.30861172
36MP0004036_abnormal_muscle_relaxation1.29591406
37MP0006035_abnormal_mitochondrial_morpho1.28222280
38MP0000689_abnormal_spleen_morphology1.26973164
39MP0003828_pulmonary_edema1.26954137
40MP0003136_yellow_coat_color1.20924407
41MP0009333_abnormal_splenocyte_physiolog1.18681735
42MP0008932_abnormal_embryonic_tissue1.17466873
43MP0002429_abnormal_blood_cell1.17151841
44MP0004215_abnormal_myocardial_fiber1.14557387
45MP0002722_abnormal_immune_system1.13969057
46MP0002733_abnormal_thermal_nociception1.13089158
47MP0010368_abnormal_lymphatic_system1.12874292
48MP0003718_maternal_effect1.12363764
49MP0002653_abnormal_ependyma_morphology1.12304031
50MP0002723_abnormal_immune_serum1.09405793
51MP0009765_abnormal_xenobiotic_induced1.09325009
52MP0000249_abnormal_blood_vessel1.09224323
53MP0001800_abnormal_humoral_immune1.06737422
54MP0001968_abnormal_touch/_nociception1.06336041
55MP0004808_abnormal_hematopoietic_stem1.04827052
56MP0004147_increased_porphyrin_level1.03765459
57MP0002452_abnormal_antigen_presenting1.00769722
58MP0000716_abnormal_immune_system0.94679524
59MP0001663_abnormal_digestive_system0.94215268
60MP0002420_abnormal_adaptive_immunity0.93772124
61MP0001765_abnormal_ion_homeostasis0.92453334
62MP0010329_abnormal_lipoprotein_level0.91694934
63MP0001819_abnormal_immune_cell0.90792117
64MP0009642_abnormal_blood_homeostasis0.90774280
65MP0004947_skin_inflammation0.90350343
66MP0000383_abnormal_hair_follicle0.89292626
67MP0000358_abnormal_cell_content/0.87342017
68MP0002138_abnormal_hepatobiliary_system0.86333567
69MP0005535_abnormal_body_temperature0.83949589
70MP0004957_abnormal_blastocyst_morpholog0.82906466
71MP0004130_abnormal_muscle_cell0.82118548
72MP0000703_abnormal_thymus_morphology0.81772980
73MP0003866_abnormal_defecation0.79988111
74MP0003879_abnormal_hair_cell0.77663846
75MP0003111_abnormal_nucleus_morphology0.75743791
76MP0005501_abnormal_skin_physiology0.75628433
77MP0001533_abnormal_skeleton_physiology0.75525812
78MP0010094_abnormal_chromosome_stability0.74326343
79MP0008874_decreased_physiological_sensi0.73050265
80MP0009764_decreased_sensitivity_to0.72748276
81MP0000685_abnormal_immune_system0.72061668
82MP0005025_abnormal_response_to0.70316091
83MP0004381_abnormal_hair_follicle0.70281586
84MP0001970_abnormal_pain_threshold0.70055457
85MP0005187_abnormal_penis_morphology0.70031832
86MP0001845_abnormal_inflammatory_respons0.69740107
87MP0005385_cardiovascular_system_phenoty0.69445989
88MP0001544_abnormal_cardiovascular_syste0.69445989
89MP0005165_increased_susceptibility_to0.68855651
90MP0001790_abnormal_immune_system0.67802835
91MP0005387_immune_system_phenotype0.67802835
92MP0000490_abnormal_crypts_of0.66904334
93MP0002972_abnormal_cardiac_muscle0.66193570
94MP0008260_abnormal_autophagy0.65935465
95MP0008058_abnormal_DNA_repair0.65843625
96MP0002019_abnormal_tumor_incidence0.64193221
97MP0005666_abnormal_adipose_tissue0.63672139
98MP0003698_abnormal_male_reproductive0.62249532
99MP0000015_abnormal_ear_pigmentation0.62139937
100MP0000858_altered_metastatic_potential0.61634129

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.58592062
2Menorrhagia (HP:0000132)9.43001623
3Petechiae (HP:0000967)9.18707442
4Abnormal platelet volume (HP:0011876)9.03353884
5Purpura (HP:0000979)8.32709547
6Epistaxis (HP:0000421)7.25523764
7Gingival bleeding (HP:0000225)6.03958881
8Impaired platelet aggregation (HP:0003540)5.49825861
9Abnormal platelet function (HP:0011869)5.49825861
10Dyschromatopsia (HP:0007641)5.38897732
11Hyperlipoproteinemia (HP:0010980)5.02590031
12Spontaneous hematomas (HP:0007420)4.17099945
13Poikilocytosis (HP:0004447)4.13646516
14Acanthocytosis (HP:0001927)4.06898391
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.43117958
16Abnormal pupillary function (HP:0007686)3.40418024
17Conjunctival telangiectasia (HP:0000524)3.23884547
18Paralysis (HP:0003470)3.07635612
19Bruising susceptibility (HP:0000978)3.07140389
20Renal Fanconi syndrome (HP:0001994)2.96448585
21Abnormal ciliary motility (HP:0012262)2.88693501
22Decreased central vision (HP:0007663)2.85094053
23Abnormality of the vasculature of the conjunctiva (HP:0008054)2.83456585
24Abnormality of the common coagulation pathway (HP:0010990)2.71749131
25Hepatosplenomegaly (HP:0001433)2.67509732
263-Methylglutaconic aciduria (HP:0003535)2.66545689
27Abnormal respiratory motile cilium morphology (HP:0005938)2.64632371
28Abnormal respiratory epithelium morphology (HP:0012253)2.64632371
29Exertional dyspnea (HP:0002875)2.62053395
30Papillary thyroid carcinoma (HP:0002895)2.60649365
31Abnormal auditory evoked potentials (HP:0006958)2.54515460
32Joint swelling (HP:0001386)2.54428272
33Generalized aminoaciduria (HP:0002909)2.54410573
34Abnormality of lateral ventricle (HP:0030047)2.48079209
35Tinnitus (HP:0000360)2.46264071
36Increased IgM level (HP:0003496)2.44244986
37Male infertility (HP:0003251)2.35865924
38Increased density of long bones (HP:0006392)2.31261036
39Hyperthyroidism (HP:0000836)2.30355322
40Abnormal respiratory motile cilium physiology (HP:0012261)2.28006496
41Elevated erythrocyte sedimentation rate (HP:0003565)2.27572551
42Thyroid-stimulating hormone excess (HP:0002925)2.20210746
43Spontaneous abortion (HP:0005268)2.19401905
44Chronic otitis media (HP:0000389)2.18098294
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.14915275
46Absent/shortened dynein arms (HP:0200106)2.14915275
47Joint hemorrhage (HP:0005261)2.11213424
48Encephalitis (HP:0002383)2.09868003
49Upper limb muscle weakness (HP:0003484)2.09727417
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05788739
51Abnormality of alanine metabolism (HP:0010916)2.05788739
52Hyperalaninemia (HP:0003348)2.05788739
53Autoimmune hemolytic anemia (HP:0001890)2.04111348
54Abnormality of iron homeostasis (HP:0011031)2.02087177
55Nausea (HP:0002018)2.00544201
56Prolonged bleeding time (HP:0003010)10.6976889
57Arterial thrombosis (HP:0004420)1.98683871
58Chronic sinusitis (HP:0011109)1.96751178
59Thyroid carcinoma (HP:0002890)1.90977914
60Abnormality of transition element cation homeostasis (HP:0011030)1.88436463
61Obstructive lung disease (HP:0006536)1.79670219
62Chronic obstructive pulmonary disease (HP:0006510)1.79670219
63Abnormality of renal resorption (HP:0011038)1.78703118
64Increased intramyocellular lipid droplets (HP:0012240)1.74386609
65Rhinitis (HP:0012384)1.74187271
66Acute necrotizing encephalopathy (HP:0006965)1.69426384
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69197651
68Xanthomatosis (HP:0000991)1.67896915
69Stomatitis (HP:0010280)1.67633641
70Thrombocytosis (HP:0001894)1.66346227
71Basal ganglia calcification (HP:0002135)1.60590552
72Abnormality of the prostate (HP:0008775)1.59188937
73Central scotoma (HP:0000603)1.57821951
74Abnormality of macrophages (HP:0004311)1.55337507
75Abnormal mitochondria in muscle tissue (HP:0008316)1.55251839
76Hypophosphatemic rickets (HP:0004912)1.54024271
77Thrombophlebitis (HP:0004418)1.53683536
78Infertility (HP:0000789)1.50016807
79Portal hypertension (HP:0001409)1.49855115
80Panhypogammaglobulinemia (HP:0003139)1.49262431
81Short middle phalanx of the 5th finger (HP:0004220)1.49154272
82Acute encephalopathy (HP:0006846)1.49092770
83Tongue fasciculations (HP:0001308)1.49030119
84Hypomagnesemia (HP:0002917)1.48770079
85Leiomyosarcoma (HP:0100243)1.48206524
86Uterine leiomyosarcoma (HP:0002891)1.48206524
87Increased hepatocellular lipid droplets (HP:0006565)1.45952012
88Abnormal spermatogenesis (HP:0008669)1.45388334
89Vertigo (HP:0002321)1.43963516
90Erythema (HP:0010783)1.41949999
91Truncus arteriosus (HP:0001660)1.41935067
92Myelodysplasia (HP:0002863)1.41399525
93Transitional cell carcinoma of the bladder (HP:0006740)1.38868899
94Renal cortical cysts (HP:0000803)1.38778759
95Amaurosis fugax (HP:0100576)1.38691979
96Episodic fever (HP:0001954)1.36566943
97Eosinophilia (HP:0001880)1.34314939
98Increased muscle lipid content (HP:0009058)1.34056163
99Abnormality of the hepatic vasculature (HP:0006707)1.33850462
100Ileus (HP:0002595)1.33848437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.48129440
2RIPK44.16083595
3BMX4.01600112
4MYLK2.95017753
5TEC2.85103577
6TAOK32.78511642
7BTK2.68104300
8EIF2AK12.36881112
9CSF1R2.25839083
10SYK2.10267534
11PTK2B2.07197861
12PIK3CG1.99102210
13STK31.86893293
14ZAK1.80254705
15VRK11.77535776
16GRK51.63086869
17ILK1.62164659
18TESK21.58144948
19ACVR1B1.57324587
20TLK11.56798764
21TRIM281.47332648
22BMPR21.42542405
23ZAP701.40332260
24NUAK11.40244456
25BCKDK1.38814492
26IRAK11.38567466
27TNIK1.32558404
28GRK61.30727562
29LMTK21.29505800
30MARK31.21722748
31STK241.20837039
32FGR1.20709736
33HCK1.16157842
34SIK31.15879784
35PAK11.15782117
36MAP3K51.13275462
37ADRBK21.11687084
38PLK21.11606414
39STK41.05854705
40FES1.05649779
41MAPKAPK31.05637285
42TNK21.03467411
43FLT31.02511827
44LYN1.02294762
45DAPK30.99780760
46CDC70.97000792
47FER0.96984552
48DYRK30.95926528
49TXK0.95724417
50KDR0.92124330
51STK160.91826736
52IKBKB0.85855869
53MATK0.85638679
54BMPR1B0.83434587
55EPHA30.81149407
56PNCK0.80916552
57PLK30.77220664
58PLK40.76858018
59TAOK20.75210697
60MKNK10.74076699
61MINK10.72888638
62ITK0.71556500
63VRK20.69242360
64PKN10.67674905
65MAP2K30.67088289
66ADRBK10.65790320
67RET0.64355926
68ERBB20.64269811
69BRSK20.62735693
70CCNB10.62581352
71DAPK10.59267891
72CDK90.58798399
73RPS6KA50.57117375
74PRKD10.56046651
75SRPK10.51994574
76DYRK20.50859512
77BLK0.50483291
78WNK40.49956878
79EPHB10.46835316
80RPS6KA40.44620789
81PINK10.44517175
82PBK0.43755919
83MAP4K10.43514865
84DYRK1B0.42938982
85PIM10.42261552
86LCK0.41987268
87AURKA0.40944696
88PRKACG0.40935414
89PIM20.36767537
90PKN20.35543135
91PRKG10.35428387
92PRKCD0.34894220
93BUB10.34129763
94NLK0.33555138
95DAPK20.33032611
96CSNK1G30.32821668
97MAP2K10.32274521
98PDK10.31550473
99PRKCQ0.31400993
100DYRK1A0.30008838

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.48507422
2Systemic lupus erythematosus_Homo sapiens_hsa053224.05392078
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.02492583
4SNARE interactions in vesicular transport_Homo sapiens_hsa041303.65564070
5Alcoholism_Homo sapiens_hsa050343.35939502
6Fatty acid elongation_Homo sapiens_hsa000622.88863997
7Mismatch repair_Homo sapiens_hsa034302.62862251
8Hematopoietic cell lineage_Homo sapiens_hsa046402.57786193
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.56185753
10Nitrogen metabolism_Homo sapiens_hsa009102.54162629
11Arachidonic acid metabolism_Homo sapiens_hsa005902.01337969
12Gap junction_Homo sapiens_hsa045401.80668423
13ECM-receptor interaction_Homo sapiens_hsa045121.80578515
14DNA replication_Homo sapiens_hsa030301.79696277
15Viral carcinogenesis_Homo sapiens_hsa052031.67814072
16Shigellosis_Homo sapiens_hsa051311.63293588
17Serotonergic synapse_Homo sapiens_hsa047261.61302042
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60061296
19Glutathione metabolism_Homo sapiens_hsa004801.53488812
20Primary immunodeficiency_Homo sapiens_hsa053401.47900761
21Chemokine signaling pathway_Homo sapiens_hsa040621.44594508
22Collecting duct acid secretion_Homo sapiens_hsa049661.39497126
23Sulfur metabolism_Homo sapiens_hsa009201.23979967
24Parkinsons disease_Homo sapiens_hsa050121.22076347
25Purine metabolism_Homo sapiens_hsa002301.20599009
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.17233573
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07907760
28Pyrimidine metabolism_Homo sapiens_hsa002401.00375724
29Olfactory transduction_Homo sapiens_hsa047400.98952743
30Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97017434
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96710959
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96485133
33Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95453416
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92889938
35Endocytosis_Homo sapiens_hsa041440.92487633
36B cell receptor signaling pathway_Homo sapiens_hsa046620.87690075
37Pancreatic secretion_Homo sapiens_hsa049720.87201691
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84949422
39Glycerolipid metabolism_Homo sapiens_hsa005610.81177225
40Steroid biosynthesis_Homo sapiens_hsa001000.75438601
41Homologous recombination_Homo sapiens_hsa034400.74371649
42Proteasome_Homo sapiens_hsa030500.74282361
43Long-term depression_Homo sapiens_hsa047300.73830426
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.72006896
45Linoleic acid metabolism_Homo sapiens_hsa005910.71401083
46Starch and sucrose metabolism_Homo sapiens_hsa005000.70089099
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68924052
48Phototransduction_Homo sapiens_hsa047440.68832582
49Base excision repair_Homo sapiens_hsa034100.67505273
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63135268
51Huntingtons disease_Homo sapiens_hsa050160.62412337
52Circadian entrainment_Homo sapiens_hsa047130.60848024
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60706291
54Oxidative phosphorylation_Homo sapiens_hsa001900.59608173
55Malaria_Homo sapiens_hsa051440.58937567
56Nucleotide excision repair_Homo sapiens_hsa034200.58310221
57Morphine addiction_Homo sapiens_hsa050320.58070857
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57721379
59One carbon pool by folate_Homo sapiens_hsa006700.56405257
60Phagosome_Homo sapiens_hsa041450.53956182
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53806280
62Cell cycle_Homo sapiens_hsa041100.53179252
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52352266
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.51488864
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51219107
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50549240
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.48861719
68Legionellosis_Homo sapiens_hsa051340.46295458
69Regulation of autophagy_Homo sapiens_hsa041400.44911429
70T cell receptor signaling pathway_Homo sapiens_hsa046600.43854174
71Choline metabolism in cancer_Homo sapiens_hsa052310.41138825
72Fat digestion and absorption_Homo sapiens_hsa049750.40963252
73Pentose phosphate pathway_Homo sapiens_hsa000300.40842516
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40241600
75Pancreatic cancer_Homo sapiens_hsa052120.39844193
76Rap1 signaling pathway_Homo sapiens_hsa040150.38715583
77beta-Alanine metabolism_Homo sapiens_hsa004100.38583210
78Graft-versus-host disease_Homo sapiens_hsa053320.37889172
79Asthma_Homo sapiens_hsa053100.37301347
80Renin-angiotensin system_Homo sapiens_hsa046140.36595963
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36338332
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.36129517
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35162706
84Arginine and proline metabolism_Homo sapiens_hsa003300.34199131
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33585577
86Chemical carcinogenesis_Homo sapiens_hsa052040.32576856
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32232780
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.31743392
89GABAergic synapse_Homo sapiens_hsa047270.31263834
90Spliceosome_Homo sapiens_hsa030400.30645137
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29994911
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28885254
93Allograft rejection_Homo sapiens_hsa053300.27378048
94Fanconi anemia pathway_Homo sapiens_hsa034600.27115505
95Oocyte meiosis_Homo sapiens_hsa041140.26865553
96Staphylococcus aureus infection_Homo sapiens_hsa051500.26550180
97Salmonella infection_Homo sapiens_hsa051320.26207024
98Calcium signaling pathway_Homo sapiens_hsa040200.25798615
99Non-homologous end-joining_Homo sapiens_hsa034500.25395260
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25239754

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »