RRN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.57774422
2nuclear pore complex assembly (GO:0051292)5.31052161
3IMP biosynthetic process (GO:0006188)5.14890580
4mitotic metaphase plate congression (GO:0007080)5.13247746
5COPI coating of Golgi vesicle (GO:0048205)4.78084785
6Golgi transport vesicle coating (GO:0048200)4.78084785
7purine nucleobase biosynthetic process (GO:0009113)4.77331551
8nucleobase biosynthetic process (GO:0046112)4.76129871
9establishment of integrated proviral latency (GO:0075713)4.47378506
10mitotic sister chromatid cohesion (GO:0007064)4.39854027
11pore complex assembly (GO:0046931)4.31961309
12IMP metabolic process (GO:0046040)4.29273879
13metaphase plate congression (GO:0051310)4.25485152
14protein localization to kinetochore (GO:0034501)4.21278046
15DNA replication initiation (GO:0006270)4.17666359
16mitotic nuclear envelope disassembly (GO:0007077)4.11166158
17DNA replication checkpoint (GO:0000076)4.07951676
18chromatin remodeling at centromere (GO:0031055)4.00258286
19CENP-A containing nucleosome assembly (GO:0034080)3.98908602
20regulation of sister chromatid cohesion (GO:0007063)3.98062260
21* ribosome biogenesis (GO:0042254)3.96807017
22COPII vesicle coating (GO:0048208)3.90691122
23establishment of chromosome localization (GO:0051303)3.85878275
24DNA replication-dependent nucleosome assembly (GO:0006335)3.84024360
25DNA replication-dependent nucleosome organization (GO:0034723)3.84024360
26regulation of posttranscriptional gene silencing (GO:0060147)3.83456653
27regulation of gene silencing by miRNA (GO:0060964)3.83456653
28regulation of gene silencing by RNA (GO:0060966)3.83456653
29protein K6-linked ubiquitination (GO:0085020)3.82946691
30nuclear envelope disassembly (GO:0051081)3.82387487
31membrane disassembly (GO:0030397)3.82387487
32kinetochore organization (GO:0051383)3.76968480
33spliceosomal tri-snRNP complex assembly (GO:0000244)3.75876599
34mitotic sister chromatid segregation (GO:0000070)3.72694850
35DNA strand elongation involved in DNA replication (GO:0006271)3.71524765
36DNA topological change (GO:0006265)3.70259581
37DNA ligation (GO:0006266)3.63485893
38ribosome assembly (GO:0042255)3.63217086
39regulation of spindle organization (GO:0090224)3.62605914
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.59246997
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.59246997
42DNA strand elongation (GO:0022616)3.54516407
43non-recombinational repair (GO:0000726)3.52832316
44double-strand break repair via nonhomologous end joining (GO:0006303)3.52832316
45protein localization to chromosome, centromeric region (GO:0071459)3.52381498
46establishment of viral latency (GO:0019043)3.52082288
47DNA replication-independent nucleosome organization (GO:0034724)3.51894231
48DNA replication-independent nucleosome assembly (GO:0006336)3.51894231
49kinetochore assembly (GO:0051382)3.49834080
50maturation of 5.8S rRNA (GO:0000460)3.48063131
51telomere maintenance via semi-conservative replication (GO:0032201)3.43812182
52spindle checkpoint (GO:0031577)3.42983858
53regulation of helicase activity (GO:0051095)3.42559970
54histone exchange (GO:0043486)3.39029200
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.37519507
56tRNA aminoacylation for protein translation (GO:0006418)3.36742161
57attachment of spindle microtubules to kinetochore (GO:0008608)3.36691439
58sister chromatid segregation (GO:0000819)3.36445063
59formation of translation preinitiation complex (GO:0001731)3.35169611
60histone H2B ubiquitination (GO:0033523)3.32621579
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.30679762
62DNA duplex unwinding (GO:0032508)3.29790876
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.28833842
64regulation of mitotic spindle checkpoint (GO:1903504)3.26845862
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26845862
66DNA geometric change (GO:0032392)3.25996989
67meiotic chromosome segregation (GO:0045132)3.25939843
68tRNA aminoacylation (GO:0043039)3.24937080
69amino acid activation (GO:0043038)3.24937080
70negative regulation of chromosome segregation (GO:0051985)3.24748350
71rRNA modification (GO:0000154)3.24340877
72cellular protein complex localization (GO:0034629)3.23809402
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.23082062
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23082062
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23082062
76negative regulation of sister chromatid segregation (GO:0033046)3.23082062
77regulation of RNA export from nucleus (GO:0046831)3.22943612
78mitotic spindle checkpoint (GO:0071174)3.22183155
79regulation of translational fidelity (GO:0006450)3.22179543
80regulation of translational initiation (GO:0006446)3.20800560
81telomere maintenance via recombination (GO:0000722)3.20626170
82regulation of mitotic metaphase/anaphase transition (GO:0030071)3.19745041
83spindle assembly checkpoint (GO:0071173)3.19341644
84positive regulation of chromosome segregation (GO:0051984)3.19089696
85mitotic recombination (GO:0006312)3.17368943
86mitotic spindle assembly checkpoint (GO:0007094)3.16501471
87inner cell mass cell proliferation (GO:0001833)3.15762536
88cullin deneddylation (GO:0010388)3.15477362
89DNA unwinding involved in DNA replication (GO:0006268)3.15433535
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12155068
91regulation of mitotic sister chromatid separation (GO:0010965)3.11886245
92regulation of mitotic sister chromatid segregation (GO:0033047)3.11886245
93regulation of sister chromatid segregation (GO:0033045)3.11886245
94regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11377296
95spliceosomal snRNP assembly (GO:0000387)3.10307359
96transcription-coupled nucleotide-excision repair (GO:0006283)3.10015804
97regulation of translational termination (GO:0006449)3.09851969
98regulation of centrosome cycle (GO:0046605)3.07978211
99regulation of chromosome segregation (GO:0051983)3.07955961
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07565247
101nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.06971089
102mitotic chromosome condensation (GO:0007076)3.06279394
103termination of RNA polymerase I transcription (GO:0006363)3.05900312
104regulation of centriole replication (GO:0046599)3.04843527
105paraxial mesoderm development (GO:0048339)3.04669621
106telomere maintenance via telomere lengthening (GO:0010833)3.04252030
107regulation of mitotic spindle organization (GO:0060236)3.04068209
108histone arginine methylation (GO:0034969)3.03309187
109RNA-dependent DNA replication (GO:0006278)3.01453042
110ribonucleoprotein complex disassembly (GO:0032988)3.00860765
111transcription elongation from RNA polymerase I promoter (GO:0006362)3.00432700
112chromosome segregation (GO:0007059)2.98438772
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97472256
114DNA double-strand break processing (GO:0000729)2.97144915
115regulation of mitochondrial translation (GO:0070129)2.96814151
116stress granule assembly (GO:0034063)2.96656524
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95851696
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95851696
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.95851696
120snRNA processing (GO:0016180)2.95378778
121protein deneddylation (GO:0000338)2.95231213
122regulation of DNA damage checkpoint (GO:2000001)2.94232042
123protein complex localization (GO:0031503)2.92623637
124microtubule depolymerization (GO:0007019)2.90968462
1257-methylguanosine mRNA capping (GO:0006370)2.90330743
126nucleotide-excision repair, DNA gap filling (GO:0006297)2.90244692
127regulation of transcription from RNA polymerase I promoter (GO:0006356)2.88873874
128mitochondrial DNA replication (GO:0006264)2.88353955
129folic acid-containing compound biosynthetic process (GO:0009396)2.88045788
130viral mRNA export from host cell nucleus (GO:0046784)2.86448206
1317-methylguanosine RNA capping (GO:0009452)2.86088439
132regulation of nucleobase-containing compound transport (GO:0032239)2.85592371
133mitochondrial DNA metabolic process (GO:0032042)2.85565393
134nuclear envelope organization (GO:0006998)2.85517595
135transcription from mitochondrial promoter (GO:0006390)2.83153082
136protein localization to chromosome (GO:0034502)2.82857996
137positive regulation of translational initiation (GO:0045948)2.81459866
138peptidyl-arginine omega-N-methylation (GO:0035247)2.78806184
139dosage compensation (GO:0007549)2.77393787
140mRNA transport (GO:0051028)2.77388403
141DNA conformation change (GO:0071103)2.74592197
142sister chromatid cohesion (GO:0007062)2.73196327
143rRNA transcription (GO:0009303)2.72783391
144regulation of translational elongation (GO:0006448)2.72315245
145negative regulation of mRNA processing (GO:0050686)2.70611092
146ribosomal large subunit biogenesis (GO:0042273)2.65871689
147ribonucleoprotein complex subunit organization (GO:0071826)2.63443217
148mRNA splicing, via spliceosome (GO:0000398)2.61383016
149RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61383016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26021481
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.10725321
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.77707997
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73501453
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30378695
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11299932
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98016146
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91795497
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.81598587
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.78563698
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75325503
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60246026
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59687137
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.57182532
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54144804
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53255704
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52197842
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43281338
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41034923
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.40092820
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39742477
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.36539748
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34249438
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.27430642
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16520914
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10904272
27AR_21909140_ChIP-Seq_LNCAP_Human2.09096292
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08517669
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06984766
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04641750
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04502698
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.97834803
33VDR_23849224_ChIP-Seq_CD4+_Human1.97491304
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96679587
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96135654
36XRN2_22483619_ChIP-Seq_HELA_Human1.93617778
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89378480
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86894612
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85211759
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.82036698
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81750848
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79367835
43ELK1_19687146_ChIP-ChIP_HELA_Human1.79308834
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.77477098
45* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76811075
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.75919613
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74532334
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.74102358
49FOXP3_21729870_ChIP-Seq_TREG_Human1.72903588
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72042434
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68300900
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68300900
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68300900
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66891763
55CLOCK_20551151_ChIP-Seq_293T_Human1.66870003
56DCP1A_22483619_ChIP-Seq_HELA_Human1.65980938
57TTF2_22483619_ChIP-Seq_HELA_Human1.60616676
58* GABP_19822575_ChIP-Seq_HepG2_Human1.58391260
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51830175
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51511237
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46819435
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43248451
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38911855
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38426323
65* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37920616
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37766495
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.36967252
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34036617
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.33892841
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33661358
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33062998
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.30820041
73KDM5A_27292631_Chip-Seq_BREAST_Human1.30794072
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30591263
75* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27710132
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27406719
77CIITA_25753668_ChIP-Seq_RAJI_Human1.27164242
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25009578
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22737481
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21277022
81CHD1_26751641_Chip-Seq_LNCaP_Human1.18068185
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17644054
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15858206
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15701116
85ZNF263_19887448_ChIP-Seq_K562_Human1.15050786
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.14479096
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14474234
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13939426
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12392840
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10522872
91IGF1R_20145208_ChIP-Seq_DFB_Human1.09630135
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08934806
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08130303
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.06588028
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06509816
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03883076
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03266854
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03171903
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02604230
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00751860
101SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00552521
102* NANOG_16153702_ChIP-ChIP_HESCs_Human1.00185239
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00102825
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99689546
105EWS_26573619_Chip-Seq_HEK293_Human0.99443422
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96005144
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95847500
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.95313634
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95256567
110MYC_18940864_ChIP-ChIP_HL60_Human0.94823768
111TFEB_21752829_ChIP-Seq_HELA_Human0.94741735
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94623113
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93837059
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93540079
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93027532
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92626056
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92467442
118* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92447886
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91636541
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91157073
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90349988
122ELF5_23300383_ChIP-Seq_T47D_Human0.90035736
123* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89869297
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89645767
125FUS_26573619_Chip-Seq_HEK293_Human0.88041321
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87134533
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.87110477
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86974396
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86816140
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86707952
131* SOX2_16153702_ChIP-ChIP_HESCs_Human0.85951015
132NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85689537
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85649992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86702381
2MP0010094_abnormal_chromosome_stability4.40577487
3MP0003111_abnormal_nucleus_morphology4.16963718
4MP0004957_abnormal_blastocyst_morpholog3.90106551
5MP0010234_abnormal_vibrissa_follicle3.76930973
6MP0003077_abnormal_cell_cycle3.60053459
7MP0008058_abnormal_DNA_repair3.40483253
8MP0008057_abnormal_DNA_replication3.36146978
9MP0008007_abnormal_cellular_replicative3.23690460
10MP0008877_abnormal_DNA_methylation2.84228392
11MP0003123_paternal_imprinting2.82356460
12MP0008932_abnormal_embryonic_tissue2.62699033
13MP0003786_premature_aging2.41295327
14MP0001730_embryonic_growth_arrest2.34480567
15MP0000350_abnormal_cell_proliferation2.32504314
16MP0002009_preneoplasia2.31038565
17MP0003718_maternal_effect2.14180045
18MP0010307_abnormal_tumor_latency2.03793088
19MP0005367_renal/urinary_system_phenotyp2.02501388
20MP0000516_abnormal_urinary_system2.02501388
21MP0003121_genomic_imprinting1.96192655
22MP0003315_abnormal_perineum_morphology1.87882754
23* MP0005380_embryogenesis_phenotype1.87368364
24* MP0001672_abnormal_embryogenesis/_devel1.87368364
25MP0004185_abnormal_adipocyte_glucose1.85073249
26MP0010030_abnormal_orbit_morphology1.75378997
27MP0006292_abnormal_olfactory_placode1.74088457
28MP0010352_gastrointestinal_tract_polyps1.69935009
29* MP0001697_abnormal_embryo_size1.67767180
30MP0004197_abnormal_fetal_growth/weight/1.64830767
31* MP0003984_embryonic_growth_retardation1.61349500
32* MP0002085_abnormal_embryonic_tissue1.60268146
33* MP0002088_abnormal_embryonic_growth/wei1.57133151
34MP0003890_abnormal_embryonic-extraembry1.54543256
35MP0003119_abnormal_digestive_system1.49986821
36MP0003806_abnormal_nucleotide_metabolis1.48789702
37MP0010678_abnormal_skin_adnexa1.48556175
38* MP0002084_abnormal_developmental_patter1.46786543
39MP0003787_abnormal_imprinting1.45140222
40* MP0002080_prenatal_lethality1.42072353
41MP0002160_abnormal_reproductive_system1.41741208
42MP0002653_abnormal_ependyma_morphology1.40173364
43MP0009053_abnormal_anal_canal1.37616383
44MP0003567_abnormal_fetal_cardiomyocyte1.36781601
45MP0002086_abnormal_extraembryonic_tissu1.36200543
46MP0003941_abnormal_skin_development1.35306608
47MP0002210_abnormal_sex_determination1.29816087
48MP0000013_abnormal_adipose_tissue1.29457143
49MP0003950_abnormal_plasma_membrane1.27846148
50MP0003656_abnormal_erythrocyte_physiolo1.27711414
51MP0004133_heterotaxia1.24574001
52MP0001727_abnormal_embryo_implantation1.24556782
53MP0005451_abnormal_body_composition1.20855450
54MP0008789_abnormal_olfactory_epithelium1.20201131
55MP0000566_synostosis1.19868417
56MP0001293_anophthalmia1.19134684
57MP0005076_abnormal_cell_differentiation1.18567101
58* MP0000313_abnormal_cell_death1.17764798
59MP0008260_abnormal_autophagy1.16319540
60MP0001188_hyperpigmentation1.14242670
61MP0004264_abnormal_extraembryonic_tissu1.14141809
62MP0003937_abnormal_limbs/digits/tail_de1.13108162
63MP0001119_abnormal_female_reproductive1.10840856
64MP0002751_abnormal_autonomic_nervous1.10289701
65MP0000627_abnormal_mammary_gland1.09073290
66MP0001661_extended_life_span1.08517968
67MP0001145_abnormal_male_reproductive1.06457553
68MP0002396_abnormal_hematopoietic_system1.06009767
69MP0002006_tumorigenesis1.05067653
70MP0002166_altered_tumor_susceptibility1.02052816
71MP0005389_reproductive_system_phenotype1.01861782
72MP0002111_abnormal_tail_morphology1.00868387
73MP0002234_abnormal_pharynx_morphology0.99678209
74MP0001849_ear_inflammation0.97285528
75MP0001286_abnormal_eye_development0.96609526
76MP0000653_abnormal_sex_gland0.95834247
77MP0005394_taste/olfaction_phenotype0.95005917
78MP0005499_abnormal_olfactory_system0.95005917
79MP0002098_abnormal_vibrissa_morphology0.94387391
80MP0009703_decreased_birth_body0.91737862
81MP0004782_abnormal_surfactant_physiolog0.91171940
82MP0005501_abnormal_skin_physiology0.91136590
83MP0000579_abnormal_nail_morphology0.91105791
84MP0001929_abnormal_gametogenesis0.90491874
85MP0000747_muscle_weakness0.90365189
86MP0001881_abnormal_mammary_gland0.87974071
87MP0000762_abnormal_tongue_morphology0.87042272
88MP0002019_abnormal_tumor_incidence0.86945807
89MP0005623_abnormal_meninges_morphology0.86580428
90MP0002877_abnormal_melanocyte_morpholog0.86041514
91MP0004808_abnormal_hematopoietic_stem0.86029274
92MP0003755_abnormal_palate_morphology0.85948132
93MP0002796_impaired_skin_barrier0.85439515
94MP0001216_abnormal_epidermal_layer0.84736133
95MP0000490_abnormal_crypts_of0.83508010
96MP0005384_cellular_phenotype0.82582669
97MP0002092_abnormal_eye_morphology0.82407660
98MP0005666_abnormal_adipose_tissue0.81751490
99MP0000432_abnormal_head_morphology0.81598315
100MP0009672_abnormal_birth_weight0.81143273
101MP0000049_abnormal_middle_ear0.80498956
102MP0004233_abnormal_muscle_weight0.80016109
103MP0003943_abnormal_hepatobiliary_system0.79752165
104MP0004087_abnormal_muscle_fiber0.78796353
105MP0000733_abnormal_muscle_development0.78724500
106MP0003868_abnormal_feces_composition0.78155691
107MP0001919_abnormal_reproductive_system0.77547273
108MP0003186_abnormal_redox_activity0.77470346
109MP0005408_hypopigmentation0.76671048
110MP0005621_abnormal_cell_physiology0.75108095
111* MP0003861_abnormal_nervous_system0.74874531
112MP0001529_abnormal_vocalization0.73798233
113MP0009697_abnormal_copulation0.73072394
114MP0003115_abnormal_respiratory_system0.72270731
115MP0000383_abnormal_hair_follicle0.72193503
116MP0003936_abnormal_reproductive_system0.71653387
117MP0004084_abnormal_cardiac_muscle0.70855300
118MP0002177_abnormal_outer_ear0.70701278
119MP0000537_abnormal_urethra_morphology0.70677712
120MP0003646_muscle_fatigue0.70426747
121MP0005266_abnormal_metabolism0.69297912
122MP0003221_abnormal_cardiomyocyte_apopto0.68905064
123MP0005248_abnormal_Harderian_gland0.68782458
124MP0000759_abnormal_skeletal_muscle0.67599559
125MP0002114_abnormal_axial_skeleton0.67578785
126MP0002697_abnormal_eye_size0.66436647
127MP0000003_abnormal_adipose_tissue0.66210696
128MP0000428_abnormal_craniofacial_morphol0.65506633
129MP0001186_pigmentation_phenotype0.64808669
130MP0000015_abnormal_ear_pigmentation0.64641841
131MP0003763_abnormal_thymus_physiology0.63899557
132MP0002233_abnormal_nose_morphology0.63480676
133MP0001915_intracranial_hemorrhage0.63449431
134MP0002269_muscular_atrophy0.63362050
135MP0000377_abnormal_hair_follicle0.63048517
136MP0010630_abnormal_cardiac_muscle0.62420701
137MP0003699_abnormal_female_reproductive0.62058359
138MP0000358_abnormal_cell_content/0.61589624
139MP0006035_abnormal_mitochondrial_morpho0.61047947
140MP0003566_abnormal_cell_adhesion0.59418892
141MP0003935_abnormal_craniofacial_develop0.58817644

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.25801144
2Degeneration of anterior horn cells (HP:0002398)4.56030935
3Abnormality of the anterior horn cell (HP:0006802)4.56030935
4Progressive external ophthalmoplegia (HP:0000590)4.32057480
5Abnormality of the labia minora (HP:0012880)4.27699146
6Carpal bone hypoplasia (HP:0001498)4.06955299
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.98916259
8Breast hypoplasia (HP:0003187)3.90656399
9Chromsome breakage (HP:0040012)3.90324688
10Insidious onset (HP:0003587)3.76621308
11Termporal pattern (HP:0011008)3.76621308
12Microvesicular hepatic steatosis (HP:0001414)3.66936878
13Patellar aplasia (HP:0006443)3.55475557
14Impulsivity (HP:0100710)3.49911441
15Aplasia/Hypoplasia of the patella (HP:0006498)3.31973289
16Rectal fistula (HP:0100590)3.26914093
17Rectovaginal fistula (HP:0000143)3.26914093
18Abnormality of the musculature of the pelvis (HP:0001469)3.25744648
19Abnormality of the hip-girdle musculature (HP:0001445)3.25744648
20Absent radius (HP:0003974)3.15594791
21Ependymoma (HP:0002888)3.14841080
22Cortical dysplasia (HP:0002539)3.11554701
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.11255307
24Intestinal fistula (HP:0100819)3.06881784
25Meckel diverticulum (HP:0002245)3.03253390
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.99936234
27Ectopic kidney (HP:0000086)2.96720350
28Aplasia involving forearm bones (HP:0009822)2.93531046
29Absent forearm bone (HP:0003953)2.93531046
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.91286239
31Abnormality of the ileum (HP:0001549)2.88471708
32Abnormality of chromosome stability (HP:0003220)2.84854773
33Supernumerary spleens (HP:0009799)2.83564391
34Sensory axonal neuropathy (HP:0003390)2.80543746
35Abnormality of the preputium (HP:0100587)2.79149609
36Curly hair (HP:0002212)2.74445277
37Medulloblastoma (HP:0002885)2.72442817
38Asymmetry of the thorax (HP:0001555)2.71542664
39Thyroid carcinoma (HP:0002890)2.68476904
40Agnosia (HP:0010524)2.65560925
41Spastic diplegia (HP:0001264)2.62123516
42Aplasia/hypoplasia of the humerus (HP:0006507)2.60536437
43Absent thumb (HP:0009777)2.60225570
44Urinary urgency (HP:0000012)2.58572955
45Volvulus (HP:0002580)2.55861475
46Vaginal fistula (HP:0004320)2.54118720
47Abnormality of glycolysis (HP:0004366)2.53036589
48Increased serum pyruvate (HP:0003542)2.50467435
49Rimmed vacuoles (HP:0003805)2.48747386
50Stenosis of the external auditory canal (HP:0000402)2.47654412
51Increased nuchal translucency (HP:0010880)2.46827027
52Abnormality of the astrocytes (HP:0100707)2.45317863
53Astrocytoma (HP:0009592)2.45317863
54Exercise-induced muscle cramps (HP:0003710)2.45284325
55Horseshoe kidney (HP:0000085)2.43626292
56Duodenal stenosis (HP:0100867)2.43024380
57Small intestinal stenosis (HP:0012848)2.43024380
58Selective tooth agenesis (HP:0001592)2.41009391
59Multiple enchondromatosis (HP:0005701)2.40129031
60Lower limb hyperreflexia (HP:0002395)2.39427876
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.37990258
62Short humerus (HP:0005792)2.36505856
63Shawl scrotum (HP:0000049)2.36174415
64Tongue fasciculations (HP:0001308)2.33824895
65Glioma (HP:0009733)2.32557686
66Nephroblastoma (Wilms tumor) (HP:0002667)2.31308674
67Embryonal renal neoplasm (HP:0011794)2.30625230
68Progressive muscle weakness (HP:0003323)2.30404530
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.30088174
70Rhabdomyosarcoma (HP:0002859)2.29120395
71Colon cancer (HP:0003003)2.28925604
72Abnormal lung lobation (HP:0002101)2.28706863
73Resting tremor (HP:0002322)2.28589299
74Breast aplasia (HP:0100783)2.26966852
75Missing ribs (HP:0000921)2.26573806
76Cerebral hypomyelination (HP:0006808)2.22545885
77Short 1st metacarpal (HP:0010034)2.22165465
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.22165465
79Sloping forehead (HP:0000340)2.15479702
80Spinal muscular atrophy (HP:0007269)2.14005124
81Oral leukoplakia (HP:0002745)2.12418632
82Aplasia/Hypoplasia involving the musculature (HP:0001460)2.12407352
83Anal stenosis (HP:0002025)2.12049357
84Gonadotropin excess (HP:0000837)2.10730740
8511 pairs of ribs (HP:0000878)2.10223133
86Muscle fibrillation (HP:0010546)2.09448420
87Transitional cell carcinoma of the bladder (HP:0006740)2.09250825
88Abnormality of the duodenum (HP:0002246)2.08356300
89Microglossia (HP:0000171)2.08226841
90Myelodysplasia (HP:0002863)2.08042986
91Proximal placement of thumb (HP:0009623)2.06939606
92Aplasia/Hypoplasia of the breasts (HP:0010311)2.06915136
93Vertebral arch anomaly (HP:0008438)2.06370795
94Orthostatic hypotension (HP:0001278)2.04532836
95Limb-girdle muscle atrophy (HP:0003797)2.04240576
96Rough bone trabeculation (HP:0100670)2.01605071
97Abnormality of the left ventricular outflow tract (HP:0011103)2.01281500
98Subaortic stenosis (HP:0001682)2.01281500
99Bladder neoplasm (HP:0009725)2.00123476
100Bladder carcinoma (HP:0002862)2.00123476
101Bone marrow hypocellularity (HP:0005528)1.99063610
102Fused cervical vertebrae (HP:0002949)1.97133605
103Micronodular cirrhosis (HP:0001413)1.96248575
104Breast carcinoma (HP:0003002)1.95102999
105Horizontal nystagmus (HP:0000666)1.95075667
106Leiomyosarcoma (HP:0100243)1.94822788
107Uterine leiomyosarcoma (HP:0002891)1.94822788
108Short thumb (HP:0009778)1.94812313
109Spastic paraplegia (HP:0001258)1.93553927
110Premature ovarian failure (HP:0008209)1.93028481
111Secondary amenorrhea (HP:0000869)1.93025636
112Long clavicles (HP:0000890)1.91724541
113Abnormality of the corticospinal tract (HP:0002492)1.91626345
114Rib fusion (HP:0000902)1.90989828
115Overlapping toe (HP:0001845)1.90438042
116Amyotrophic lateral sclerosis (HP:0007354)1.90321983
117Back pain (HP:0003418)1.90034356
118Irregular epiphyses (HP:0010582)1.87126310
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85526129
120Triphalangeal thumb (HP:0001199)1.85450374
121Deep philtrum (HP:0002002)1.84904487
122Shoulder girdle muscle weakness (HP:0003547)1.84531282
123Limb-girdle muscle weakness (HP:0003325)1.83883551
124Cafe-au-lait spot (HP:0000957)1.83343141
125Cystic hygroma (HP:0000476)1.82334059
126Subacute progressive viral hepatitis (HP:0006572)1.82211240
127Embryonal neoplasm (HP:0002898)1.80195834
128Abnormality of the 1st metacarpal (HP:0010009)1.79592698
129Optic nerve coloboma (HP:0000588)1.79424242
130Neoplasm of the pancreas (HP:0002894)1.77468272
131Upper limb muscle weakness (HP:0003484)1.77386978
132Gastrointestinal carcinoma (HP:0002672)1.77344884
133Malignant gastrointestinal tract tumors (HP:0006749)1.77344884
134Cutaneous melanoma (HP:0012056)1.76551400
135Papillary thyroid carcinoma (HP:0002895)1.76382575
136Deviation of the thumb (HP:0009603)1.74083801
137Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73555712
138Tracheoesophageal fistula (HP:0002575)1.73335960
139Pelvic girdle muscle weakness (HP:0003749)1.71681017
140Premature graying of hair (HP:0002216)1.71298743
141Abnormality of the carotid arteries (HP:0005344)1.70565087
142Freckling (HP:0001480)1.70314847
143Entropion (HP:0000621)1.69878380
144Intestinal atresia (HP:0011100)1.68488691
145Limb hypertonia (HP:0002509)1.68425343
146Biliary tract neoplasm (HP:0100574)1.68308430
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68062025
148Neoplasm of the thyroid gland (HP:0100031)1.65707739
149Septate vagina (HP:0001153)1.65640946
150Paraplegia (HP:0010550)1.65221765
151Impaired vibration sensation in the lower limbs (HP:0002166)1.64962201
152Poikiloderma (HP:0001029)1.63428879
153Facial cleft (HP:0002006)1.62774778
154Neoplasm of the oral cavity (HP:0100649)1.62100895
155Hypoglycemic coma (HP:0001325)1.62009379
156Tetraparesis (HP:0002273)1.61271600
157Abnormality of abdominal situs (HP:0011620)1.61101139
158Abdominal situs inversus (HP:0003363)1.61101139
159Symptomatic seizures (HP:0011145)1.60743849
160Slender long bone (HP:0003100)1.60709541
161Disinhibition (HP:0000734)1.60451799
162Pancreatic islet-cell hyperplasia (HP:0004510)1.60350541
163Exercise-induced myalgia (HP:0003738)1.59989262
164Amaurosis fugax (HP:0100576)1.59903704
165Type 2 muscle fiber atrophy (HP:0003554)1.59876374
166Postnatal microcephaly (HP:0005484)1.59610876
167Clubbing of toes (HP:0100760)1.58866017
168Septo-optic dysplasia (HP:0100842)1.58832006
169Abnormality of the metopic suture (HP:0005556)1.57754072
170Prominent metopic ridge (HP:0005487)1.57643817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.50744887
2SRPK13.50571419
3EIF2AK13.44078188
4WEE13.34808455
5CDC73.21344735
6AKT33.13307781
7NEK12.79629936
8TSSK62.67266415
9MKNK12.66614639
10PLK32.61845238
11STK38L2.57010581
12BRSK22.56507867
13MKNK22.52857454
14ZAK2.52750937
15TRIM282.36125882
16PLK42.24904782
17PLK12.06218191
18EIF2AK31.95657374
19TTK1.92424202
20CDK121.90341664
21NEK21.70072337
22KSR11.63179589
23EPHA21.60237529
24BRSK11.59295390
25MUSK1.58546644
26ERBB31.57018027
27VRK11.54195518
28MST1R1.51184673
29CHEK21.49773462
30PBK1.45142068
31BRAF1.42755981
32PASK1.37523307
33PKN21.37518675
34ATR1.37183278
35EIF2AK21.36994366
36AURKB1.29312947
37PLK21.28439984
38ACVR1B1.28157416
39AURKA1.25342365
40CDK71.25020051
41STK241.21178804
42MAP3K101.19362117
43TAF11.17399177
44MAP3K91.16618423
45CHEK11.14126437
46EEF2K1.13277894
47RPS6KB21.10181315
48LATS21.08988076
49NEK61.07045826
50SGK21.05397117
51CCNB11.04895661
52IRAK31.03322673
53MST41.01487381
54PIM10.93679792
55CSNK1G10.92477477
56ATM0.90384215
57CDK90.90240019
58STK40.88813445
59TLK10.88078782
60YES10.88064624
61PRPF4B0.87299380
62CSNK1G30.86836480
63PDGFRA0.85850234
64STK160.85158801
65PDK30.84084800
66PDK40.84084800
67* CDK20.83444479
68RAF10.81246881
69KSR20.79180646
70RPS6KA40.75763494
71LATS10.74657906
72CSNK1G20.74502886
73BRD40.73825070
74PDK20.72841340
75CDK80.71481534
76MAP2K70.71460834
77CSNK1A1L0.70981556
78MAP3K120.70924378
79MAP3K40.69476112
80CDK10.69131736
81FGFR10.68986300
82SMG10.68227559
83ARAF0.68073328
84ALK0.67133474
85CDK40.66893284
86CDK30.66333506
87STK30.65466200
88MAP3K50.64405186
89PRKCI0.63993280
90SIK30.63647907
91MAP3K80.62357661
92MELK0.61957576
93BMPR20.61712848
94EPHA30.61658322
95ERBB40.61547952
96SCYL20.60745389
97PINK10.56589585
98CLK10.56470481
99MARK30.56445918
100RPS6KB10.54814447
101* CSNK2A10.54551836
102PNCK0.54381918
103BCR0.53663694
104CSNK2A20.52838610
105SGK30.51866835
106DYRK20.51742921
107MET0.51710421
108DYRK30.51652555
109TESK20.49594608
110NEK90.48415853
111LIMK10.44032737
112OBSCN0.43355140
113CASK0.42984098
114PIM20.41315716
115FLT30.40235118
116NUAK10.40129665
117TRIB30.39629594
118FGFR30.39344721
119RPS6KC10.39291666
120RPS6KL10.39291666
121TGFBR10.39076147
122CSNK1D0.38814079
123MAPK140.35798996
124AKT20.35773451
125TAOK20.35540531
126STK100.34353581
127SGK2230.34132022
128SGK4940.34132022
129PAK20.33672756
130TESK10.33455849
131CSNK1E0.33387662
132PAK10.33379599
133CDK180.32698470
134CHUK0.32546151
135MAP3K140.30796717
136TRPM70.30036445
137RPS6KA60.29460199
138CDK60.29088197
139PRKDC0.27529404
140PAK40.26053024

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.48198812
2DNA replication_Homo sapiens_hsa030304.21570043
3Mismatch repair_Homo sapiens_hsa034304.11411334
4RNA polymerase_Homo sapiens_hsa030203.66120429
5RNA transport_Homo sapiens_hsa030133.51115563
6Proteasome_Homo sapiens_hsa030503.13503980
7Cell cycle_Homo sapiens_hsa041103.07020952
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05172218
9Spliceosome_Homo sapiens_hsa030403.01846384
10Homologous recombination_Homo sapiens_hsa034402.96072087
11Nucleotide excision repair_Homo sapiens_hsa034202.90043279
12One carbon pool by folate_Homo sapiens_hsa006702.84555812
13Base excision repair_Homo sapiens_hsa034102.77534377
14Fanconi anemia pathway_Homo sapiens_hsa034602.49708139
15Basal transcription factors_Homo sapiens_hsa030222.46094608
16Pyrimidine metabolism_Homo sapiens_hsa002402.28212618
17RNA degradation_Homo sapiens_hsa030182.20468687
18mRNA surveillance pathway_Homo sapiens_hsa030152.14888226
19Non-homologous end-joining_Homo sapiens_hsa034502.07279206
20p53 signaling pathway_Homo sapiens_hsa041151.71467414
21Purine metabolism_Homo sapiens_hsa002301.48253857
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36355041
23Oocyte meiosis_Homo sapiens_hsa041141.34667979
24Epstein-Barr virus infection_Homo sapiens_hsa051691.30113666
25Ribosome_Homo sapiens_hsa030101.25458921
26Systemic lupus erythematosus_Homo sapiens_hsa053221.13343712
27Vitamin B6 metabolism_Homo sapiens_hsa007501.11380034
28Circadian rhythm_Homo sapiens_hsa047101.05569126
29Viral carcinogenesis_Homo sapiens_hsa052031.01934679
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01527702
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00761553
32Thyroid cancer_Homo sapiens_hsa052160.98089248
33Propanoate metabolism_Homo sapiens_hsa006400.97007452
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90454443
35Chronic myeloid leukemia_Homo sapiens_hsa052200.88892507
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88537545
37Pyruvate metabolism_Homo sapiens_hsa006200.88006908
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.86768717
39Biosynthesis of amino acids_Homo sapiens_hsa012300.85809300
40MicroRNAs in cancer_Homo sapiens_hsa052060.82792880
41Steroid biosynthesis_Homo sapiens_hsa001000.82685367
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80652719
43Hippo signaling pathway_Homo sapiens_hsa043900.77210100
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76657337
45Pancreatic cancer_Homo sapiens_hsa052120.71329903
46Selenocompound metabolism_Homo sapiens_hsa004500.71253470
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71207944
48TGF-beta signaling pathway_Homo sapiens_hsa043500.69659766
49Insulin signaling pathway_Homo sapiens_hsa049100.69490470
50HTLV-I infection_Homo sapiens_hsa051660.67238019
51Herpes simplex infection_Homo sapiens_hsa051680.65931896
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65246286
53Prolactin signaling pathway_Homo sapiens_hsa049170.62729624
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62724627
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62676623
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62672275
57Alcoholism_Homo sapiens_hsa050340.59611770
58AMPK signaling pathway_Homo sapiens_hsa041520.58966557
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58532594
60Lysine degradation_Homo sapiens_hsa003100.57330959
61Antigen processing and presentation_Homo sapiens_hsa046120.54714703
62Fructose and mannose metabolism_Homo sapiens_hsa000510.54499781
63Colorectal cancer_Homo sapiens_hsa052100.51093174
64Huntingtons disease_Homo sapiens_hsa050160.51003611
65Proteoglycans in cancer_Homo sapiens_hsa052050.50684322
66Fatty acid metabolism_Homo sapiens_hsa012120.50388987
67Melanoma_Homo sapiens_hsa052180.49637843
68Adherens junction_Homo sapiens_hsa045200.49154754
69Measles_Homo sapiens_hsa051620.49075226
70Fatty acid elongation_Homo sapiens_hsa000620.48278482
71Basal cell carcinoma_Homo sapiens_hsa052170.47626905
72Endometrial cancer_Homo sapiens_hsa052130.46557953
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.45710147
74Inositol phosphate metabolism_Homo sapiens_hsa005620.44217775
75Carbon metabolism_Homo sapiens_hsa012000.44120529
76Vibrio cholerae infection_Homo sapiens_hsa051100.43835362
77ErbB signaling pathway_Homo sapiens_hsa040120.43471673
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.42143908
79Renal cell carcinoma_Homo sapiens_hsa052110.41712280
80Fatty acid biosynthesis_Homo sapiens_hsa000610.41595357
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40869792
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39930547
83HIF-1 signaling pathway_Homo sapiens_hsa040660.39074197
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39063439
85Legionellosis_Homo sapiens_hsa051340.38112286
86Acute myeloid leukemia_Homo sapiens_hsa052210.37324138
87Small cell lung cancer_Homo sapiens_hsa052220.35747638
88T cell receptor signaling pathway_Homo sapiens_hsa046600.35268595
89Tight junction_Homo sapiens_hsa045300.35148882
90mTOR signaling pathway_Homo sapiens_hsa041500.35023998
91Sphingolipid metabolism_Homo sapiens_hsa006000.34335799
92Pentose phosphate pathway_Homo sapiens_hsa000300.34044764
93Glioma_Homo sapiens_hsa052140.32723958
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32260830
95Galactose metabolism_Homo sapiens_hsa000520.31506377
96Insulin resistance_Homo sapiens_hsa049310.31432225
97FoxO signaling pathway_Homo sapiens_hsa040680.31190662
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30954702
99Prostate cancer_Homo sapiens_hsa052150.30729482
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.30296349
101Hedgehog signaling pathway_Homo sapiens_hsa043400.30016653
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.29925637
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29911823
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29684541
105Glucagon signaling pathway_Homo sapiens_hsa049220.29678219
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29629246
107Pathways in cancer_Homo sapiens_hsa052000.28260208
108Bladder cancer_Homo sapiens_hsa052190.27831055
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27243073
110Apoptosis_Homo sapiens_hsa042100.27078861
111Notch signaling pathway_Homo sapiens_hsa043300.25158001
112Arachidonic acid metabolism_Homo sapiens_hsa005900.24921103
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23683212
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23391266
115Wnt signaling pathway_Homo sapiens_hsa043100.23102710
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20692651
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20346842
118Influenza A_Homo sapiens_hsa051640.19359917
119Regulation of autophagy_Homo sapiens_hsa041400.17466017
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16563324
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15393388
122Glutathione metabolism_Homo sapiens_hsa004800.14682404
123N-Glycan biosynthesis_Homo sapiens_hsa005100.14558867
124Hepatitis B_Homo sapiens_hsa051610.12684096
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12313214
126Type I diabetes mellitus_Homo sapiens_hsa049400.10776811
127Metabolic pathways_Homo sapiens_hsa011000.10609231
128Viral myocarditis_Homo sapiens_hsa054160.07856340
129Shigellosis_Homo sapiens_hsa051310.05949673
130Phototransduction_Homo sapiens_hsa047440.05238487
131Non-small cell lung cancer_Homo sapiens_hsa052230.04999509
132Protein export_Homo sapiens_hsa030600.04310155

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