RRN3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.01648213
2regulation of B cell receptor signaling pathway (GO:0050855)5.71653366
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52149661
4positive regulation of B cell differentiation (GO:0045579)4.45231591
5regulation of gamma-delta T cell activation (GO:0046643)4.14681645
6neutrophil activation involved in immune response (GO:0002283)4.14332661
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.11525112
8mast cell activation (GO:0045576)4.06671938
9negative thymic T cell selection (GO:0045060)4.05338506
10negative regulation of cell killing (GO:0031342)4.05188060
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05188060
12negative T cell selection (GO:0043383)4.03194515
13positive regulation of granulocyte differentiation (GO:0030854)4.00359081
14cellular extravasation (GO:0045123)3.99190629
15regulation of gamma-delta T cell differentiation (GO:0045586)3.98742599
16positive thymic T cell selection (GO:0045059)3.96013154
17B cell receptor signaling pathway (GO:0050853)3.92815011
18T cell migration (GO:0072678)3.89174569
19antigen processing and presentation of endogenous antigen (GO:0019883)3.78720134
20negative regulation of interleukin-12 production (GO:0032695)3.77956569
21regulation of B cell differentiation (GO:0045577)3.77757536
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.65029102
23immunoglobulin mediated immune response (GO:0016064)3.61093812
24regulation of alpha-beta T cell proliferation (GO:0046640)3.59331537
25mast cell activation involved in immune response (GO:0002279)3.55688049
26mast cell degranulation (GO:0043303)3.55688049
27positive T cell selection (GO:0043368)3.52441081
28cellular response to interleukin-15 (GO:0071350)3.48306181
29myeloid cell activation involved in immune response (GO:0002275)3.45198480
30regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.44147454
31leukocyte degranulation (GO:0043299)3.41959005
32regulation of mast cell activation (GO:0033003)3.41704656
33positive regulation of mast cell activation (GO:0033005)3.34647362
34regulation of tolerance induction (GO:0002643)3.32864823
35response to peptidoglycan (GO:0032494)3.30729118
36neutrophil activation (GO:0042119)3.29289372
37negative regulation of B cell proliferation (GO:0030889)3.29224300
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28139222
39negative regulation of T cell mediated immunity (GO:0002710)3.26458063
40response to interleukin-15 (GO:0070672)3.26221738
41negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.23009039
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17777582
43regulation of T cell tolerance induction (GO:0002664)3.16923522
44antigen receptor-mediated signaling pathway (GO:0050851)3.16609259
45interferon-gamma production (GO:0032609)3.15395912
46mature B cell differentiation involved in immune response (GO:0002313)3.13346748
47activated T cell proliferation (GO:0050798)3.12940941
48T cell selection (GO:0045058)3.12186645
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12094988
50mature B cell differentiation (GO:0002335)3.09626170
51interferon-gamma-mediated signaling pathway (GO:0060333)3.06525345
52regulation of regulatory T cell differentiation (GO:0045589)3.04839158
53microglial cell activation (GO:0001774)3.03339890
54positive regulation of mast cell degranulation (GO:0043306)3.02047028
55positive regulation of mast cell activation involved in immune response (GO:0033008)3.02047028
56regulation of mast cell degranulation (GO:0043304)3.01589894
57positive regulation of alpha-beta T cell proliferation (GO:0046641)2.99355448
58T cell costimulation (GO:0031295)2.98482308
59tolerance induction (GO:0002507)2.97864722
60granulocyte activation (GO:0036230)2.97798569
61positive regulation by symbiont of host defense response (GO:0052509)2.95825482
62modulation by symbiont of host defense response (GO:0052031)2.95825482
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95825482
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95825482
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.95825482
66modulation by symbiont of host immune response (GO:0052553)2.95825482
67lymphocyte costimulation (GO:0031294)2.94992971
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94103342
69positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93018338
70Peyers patch development (GO:0048541)2.92332663
71mucosal-associated lymphoid tissue development (GO:0048537)2.92332663
72regulation of granulocyte differentiation (GO:0030852)2.91378669
73positive regulation of tolerance induction (GO:0002645)2.89857637
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.89811726
75regulation of hypersensitivity (GO:0002883)2.89421475
76macrophage activation involved in immune response (GO:0002281)2.88926990
77T cell receptor signaling pathway (GO:0050852)2.87434164
78detection of molecule of bacterial origin (GO:0032490)2.87265711
79B cell mediated immunity (GO:0019724)2.86312001
80regulation of B cell proliferation (GO:0030888)2.85598091
81detection of other organism (GO:0098543)2.83609757
82defense response to protozoan (GO:0042832)2.83246281
83regulation of alpha-beta T cell activation (GO:0046634)2.83151144
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83139604
85regulation of mast cell activation involved in immune response (GO:0033006)2.83110153
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81898177
87response to host immune response (GO:0052572)2.81898177
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81693686
89regulation of natural killer cell mediated immunity (GO:0002715)2.81693686
90positive regulation of interleukin-2 production (GO:0032743)2.80478677
91thymic T cell selection (GO:0045061)2.80274006
92regulation of antigen processing and presentation (GO:0002577)2.80150165
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79338325
94T cell proliferation (GO:0042098)2.78885417
95negative regulation of alpha-beta T cell activation (GO:0046636)2.78680295
96leukocyte aggregation (GO:0070486)2.78038664
97regulation of T cell mediated cytotoxicity (GO:0001914)2.76008338
98regulation of T cell receptor signaling pathway (GO:0050856)2.75345242
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.74960485
100response to muramyl dipeptide (GO:0032495)2.72939217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.48274375
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.74546087
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.55935840
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.28804223
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.21654967
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22610980
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15781792
8RUNX_20019798_ChIP-Seq_JUKART_Human3.03219399
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90358958
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.81804297
11MYB_26560356_Chip-Seq_TH2_Human2.78206463
12SCL_19346495_ChIP-Seq_HPC-7_Human2.73872881
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73628219
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58730616
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52721954
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43562135
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43395656
18SPI1_23547873_ChIP-Seq_NB4_Human2.33930952
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23512046
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14964948
21GATA3_27048872_Chip-Seq_THYMUS_Human2.11246044
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10381637
23GATA3_26560356_Chip-Seq_TH2_Human2.09424980
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04477266
25MYB_26560356_Chip-Seq_TH1_Human2.00307679
26VDR_24787735_ChIP-Seq_THP-1_Human2.00254023
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96926584
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90916914
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89532978
30SPI1_23127762_ChIP-Seq_K562_Human1.70032221
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69188716
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67595966
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66718954
34VDR_24763502_ChIP-Seq_THP-1_Human1.59509567
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57767134
36GATA1_22025678_ChIP-Seq_K562_Human1.53299571
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51047760
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49175259
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.46094384
40VDR_22108803_ChIP-Seq_LS180_Human1.44606665
41IGF1R_20145208_ChIP-Seq_DFB_Human1.43918652
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42138338
43MAF_26560356_Chip-Seq_TH1_Human1.40664071
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39186092
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.38434401
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.29834151
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29789621
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29444274
49VDR_23849224_ChIP-Seq_CD4+_Human1.28438388
50UTX_26944678_Chip-Seq_JUKART_Human1.25401672
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.24191038
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22981622
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21908839
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17932246
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16973564
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.14783614
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14652627
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13788353
59CIITA_25753668_ChIP-Seq_RAJI_Human1.13148969
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07261664
61ER_23166858_ChIP-Seq_MCF-7_Human1.03760221
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03488723
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03467442
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02637143
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00952379
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00761528
67MAF_26560356_Chip-Seq_TH2_Human0.99201762
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97990289
69SMRT_27268052_Chip-Seq_Bcells_Human0.97253856
70PRDM14_20953172_ChIP-Seq_ESCs_Human0.97088691
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97047416
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96341099
73PU_27001747_Chip-Seq_BMDM_Mouse0.96234596
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95247603
75FOXP3_21729870_ChIP-Seq_TREG_Human0.94904898
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94502910
77TAF15_26573619_Chip-Seq_HEK293_Human0.92589444
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90842872
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90324640
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89739362
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87323782
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87065669
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.87002078
84TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84490612
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83257516
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81747479
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80675424
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80124879
89TP53_22573176_ChIP-Seq_HFKS_Human0.79264615
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79263543
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78838727
92CBP_20019798_ChIP-Seq_JUKART_Human0.78838727
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77994360
94GABP_17652178_ChIP-ChIP_JURKAT_Human0.77404326
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.75468629
96* GATA3_26560356_Chip-Seq_TH1_Human0.75431758
97NANOG_19829295_ChIP-Seq_ESCs_Human0.74640663
98SOX2_19829295_ChIP-Seq_ESCs_Human0.74640663
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74631131
100EWS_26573619_Chip-Seq_HEK293_Human0.73889879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.25502388
2MP0005671_abnormal_response_to4.16917902
3MP0003724_increased_susceptibility_to3.93252992
4MP0005000_abnormal_immune_tolerance3.23828775
5MP0001800_abnormal_humoral_immune3.22665674
6MP0003436_decreased_susceptibility_to3.00817437
7MP0009785_altered_susceptibility_to2.98464987
8MP0003763_abnormal_thymus_physiology2.87867171
9MP0002723_abnormal_immune_serum2.68207730
10MP0002452_abnormal_antigen_presenting2.65214312
11MP0000685_abnormal_immune_system2.65178791
12MP0000569_abnormal_digit_pigmentation2.63143236
13MP0005387_immune_system_phenotype2.56873965
14MP0001790_abnormal_immune_system2.56873965
15MP0002420_abnormal_adaptive_immunity2.56625460
16MP0002148_abnormal_hypersensitivity_rea2.56433153
17MP0001819_abnormal_immune_cell2.54592587
18MP0002419_abnormal_innate_immunity2.54025195
19MP0005025_abnormal_response_to2.47439100
20MP0003303_peritoneal_inflammation2.36976017
21MP0009764_decreased_sensitivity_to2.12650787
22MP0005464_abnormal_platelet_physiology2.12105585
23MP0002398_abnormal_bone_marrow2.08953769
24MP0002405_respiratory_system_inflammati2.07929386
25MP0000716_abnormal_immune_system2.00470620
26MP0003828_pulmonary_edema1.99836315
27MP0006082_CNS_inflammation1.95777430
28MP0000689_abnormal_spleen_morphology1.87298555
29MP0001845_abnormal_inflammatory_respons1.74847331
30MP0009333_abnormal_splenocyte_physiolog1.71253229
31MP0002722_abnormal_immune_system1.71089633
32MP0001853_heart_inflammation1.68511294
33MP0002429_abnormal_blood_cell1.61457878
34MP0010155_abnormal_intestine_physiology1.60712628
35MP0003656_abnormal_erythrocyte_physiolo1.57887543
36MP0005075_abnormal_melanosome_morpholog1.57823276
37MP0001533_abnormal_skeleton_physiology1.56780464
38MP0002132_abnormal_respiratory_system1.56485816
39MP0000465_gastrointestinal_hemorrhage1.56303498
40MP0003866_abnormal_defecation1.55429457
41MP0003183_abnormal_peptide_metabolism1.55343029
42MP0005084_abnormal_gallbladder_morpholo1.53828713
43MP0000703_abnormal_thymus_morphology1.52894086
44MP0009278_abnormal_bone_marrow1.44882126
45MP0002166_altered_tumor_susceptibility1.41697878
46MP0005310_abnormal_salivary_gland1.39252998
47MP0001545_abnormal_hematopoietic_system1.38616805
48MP0005397_hematopoietic_system_phenotyp1.38616805
49MP0008961_abnormal_basal_metabolism1.36220354
50MP0002396_abnormal_hematopoietic_system1.32355468
51MP0008469_abnormal_protein_level1.29903895
52MP0004947_skin_inflammation1.28141551
53MP0004381_abnormal_hair_follicle1.25906671
54MP0003300_gastrointestinal_ulcer1.22696042
55MP0009765_abnormal_xenobiotic_induced1.21752511
56MP0002138_abnormal_hepatobiliary_system1.17075021
57MP0004147_increased_porphyrin_level1.12022061
58MP0001986_abnormal_taste_sensitivity1.08785485
59MP0002009_preneoplasia1.07993348
60MP0009763_increased_sensitivity_to1.06002909
61MP0003172_abnormal_lysosome_physiology1.02967504
62MP0001851_eye_inflammation1.01351756
63MP0002822_catalepsy0.99891124
64MP0003191_abnormal_cellular_cholesterol0.99303944
65MP0002006_tumorigenesis0.98860735
66MP0005167_abnormal_blood-brain_barrier0.97108265
67MP0005410_abnormal_fertilization0.95958663
68MP0005174_abnormal_tail_pigmentation0.95940433
69MP0004808_abnormal_hematopoietic_stem0.95635681
70MP0004883_abnormal_blood_vessel0.94772662
71MP0008004_abnormal_stomach_pH0.94355073
72MP0000015_abnormal_ear_pigmentation0.93122983
73MP0002933_joint_inflammation0.88652600
74MP0003806_abnormal_nucleotide_metabolis0.87300110
75MP0002998_abnormal_bone_remodeling0.82437976
76MP0003045_fibrosis0.79993711
77MP0008877_abnormal_DNA_methylation0.77656365
78MP0006035_abnormal_mitochondrial_morpho0.77220000
79MP0005166_decreased_susceptibility_to0.77084574
80MP0000858_altered_metastatic_potential0.70966363
81MP0000249_abnormal_blood_vessel0.70853466
82MP0000343_altered_response_to0.69896275
83MP0001873_stomach_inflammation0.67173567
84MP0005164_abnormal_response_to0.66805681
85MP0008995_early_reproductive_senescence0.66733436
86MP0004484_altered_response_of0.64087528
87MP0008875_abnormal_xenobiotic_pharmacok0.63916606
88MP0001501_abnormal_sleep_pattern0.62679684
89MP0002019_abnormal_tumor_incidence0.62105003
90MP0003075_altered_response_to0.61622475
91MP0002136_abnormal_kidney_physiology0.61441671
92MP0006072_abnormal_retinal_apoptosis0.60863485
93MP0005390_skeleton_phenotype0.59767084
94MP0005365_abnormal_bile_salt0.59618494
95MP0001663_abnormal_digestive_system0.59538049
96MP0003252_abnormal_bile_duct0.59205564
97MP0003646_muscle_fatigue0.57641032
98MP0006054_spinal_hemorrhage0.57462562
99MP0002277_abnormal_respiratory_mucosa0.55410802
100MP0003787_abnormal_imprinting0.55401650

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.84550542
2Myositis (HP:0100614)4.41338281
3Recurrent bacterial skin infections (HP:0005406)4.23944845
4T lymphocytopenia (HP:0005403)4.10695854
5Optic neuritis (HP:0100653)4.07346395
6Retrobulbar optic neuritis (HP:0100654)4.07346395
7Recurrent abscess formation (HP:0002722)4.07125464
8Abnormality of T cell number (HP:0011839)3.96913942
9Recurrent fungal infections (HP:0002841)3.96561574
10Stomatitis (HP:0010280)3.89082458
11Panhypogammaglobulinemia (HP:0003139)3.77620544
12Recurrent cutaneous fungal infections (HP:0011370)3.76747926
13Chronic mucocutaneous candidiasis (HP:0002728)3.76747926
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.75692413
15Orchitis (HP:0100796)3.67424038
16Mediastinal lymphadenopathy (HP:0100721)3.62168598
17Meningitis (HP:0001287)3.54179755
18Recurrent viral infections (HP:0004429)3.52821326
19Vasculitis (HP:0002633)3.49617550
20Abnormality of T cells (HP:0002843)3.41913066
21Gastrointestinal infarctions (HP:0005244)3.40425190
22Encephalitis (HP:0002383)3.37300714
23IgG deficiency (HP:0004315)3.36580046
24Recurrent skin infections (HP:0001581)3.32426517
25Agammaglobulinemia (HP:0004432)3.31006421
26Autoimmune hemolytic anemia (HP:0001890)3.21364481
27Keratoconjunctivitis sicca (HP:0001097)3.14129105
28Eczematoid dermatitis (HP:0000976)3.11828085
29Obstructive lung disease (HP:0006536)3.05597302
30Chronic obstructive pulmonary disease (HP:0006510)3.05597302
31Abnormality of the prostate (HP:0008775)3.05333440
32Eosinophilia (HP:0001880)2.99544718
33Hemoptysis (HP:0002105)2.99375100
34Keratoconjunctivitis (HP:0001096)2.99307059
35Pulmonary infiltrates (HP:0002113)2.96221372
36Abnormality of B cell number (HP:0010975)2.92835762
37Abnormality of eosinophils (HP:0001879)2.91957289
38Leukocytosis (HP:0001974)2.91571566
39Granulocytopenia (HP:0001913)2.86774360
40IgM deficiency (HP:0002850)2.83526618
41Abnormality of glycolipid metabolism (HP:0010969)2.82300923
42Abnormality of liposaccharide metabolism (HP:0010968)2.82300923
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.82300923
44Recurrent bronchitis (HP:0002837)2.81413128
45Pustule (HP:0200039)2.80925814
46Severe combined immunodeficiency (HP:0004430)2.80177514
47Abnormality of T cell physiology (HP:0011840)2.75553723
48Abnormality of macrophages (HP:0004311)2.71050487
49Colitis (HP:0002583)2.64199635
50Chest pain (HP:0100749)2.63568112
51Absent/shortened dynein arms (HP:0200106)2.61357159
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.61357159
53Epistaxis (HP:0000421)2.60249498
54Arterial thrombosis (HP:0004420)2.59456834
55Gangrene (HP:0100758)2.59227543
56Increased IgM level (HP:0003496)2.58887685
57Congenital, generalized hypertrichosis (HP:0004540)2.52807288
58Autoimmune thrombocytopenia (HP:0001973)2.48483900
59Thick nail (HP:0001805)2.47240784
60Pancreatic islet-cell hyperplasia (HP:0004510)2.45981349
61Recurrent gram-negative bacterial infections (HP:0005420)2.45799129
62Inflammation of the large intestine (HP:0002037)2.44666009
63B lymphocytopenia (HP:0010976)2.44020297
64Prolonged bleeding time (HP:0003010)2.40437747
65Recurrent sinusitis (HP:0011108)2.34802160
66Chronic sinusitis (HP:0011109)2.30886896
67Pulmonary embolism (HP:0002204)2.26590012
68Polyneuropathy (HP:0001271)2.24598675
69Abnormality of the columella (HP:0009929)2.23467737
70Long foot (HP:0001833)2.22571435
71Abnormality of the pleura (HP:0002103)2.21212054
72Gastrointestinal inflammation (HP:0004386)2.20371272
73Thyroiditis (HP:0100646)2.17907787
74Joint swelling (HP:0001386)2.17756452
75Combined immunodeficiency (HP:0005387)2.17537814
76Spontaneous hematomas (HP:0007420)2.16709635
77Anorexia (HP:0002039)2.15575714
78Abnormality of male internal genitalia (HP:0000022)2.13734112
79Fatigue (HP:0012378)2.10226258
80Verrucae (HP:0200043)2.08540537
81Papilloma (HP:0012740)2.08540537
82Amaurosis fugax (HP:0100576)2.08457107
83Vertigo (HP:0002321)2.04793838
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02410933
85Lymphopenia (HP:0001888)2.02131872
86Urticaria (HP:0001025)2.01149954
87Amyloidosis (HP:0011034)1.96777312
88Abnormality of iron homeostasis (HP:0011031)1.95542090
89Gingival bleeding (HP:0000225)1.95356378
90Stomach cancer (HP:0012126)1.93383113
91Keratitis (HP:0000491)1.93084024
92Glomerulopathy (HP:0100820)1.92864281
93Skin rash (HP:0000988)1.91961069
94Chronic diarrhea (HP:0002028)1.90219683
95Abnormality of transition element cation homeostasis (HP:0011030)1.88491571
96Bronchitis (HP:0012387)1.87955360
97Increased serum ferritin (HP:0003281)1.87865894
98IgA deficiency (HP:0002720)1.87798706
99Abnormality of cells of the lymphoid lineage (HP:0012140)1.86969480
100Thrombocytosis (HP:0001894)1.86474371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.08850082
2TXK4.24430848
3TAOK33.78676333
4MAP4K13.40683926
5BLK3.16899862
6BCKDK2.82692297
7FES2.39325664
8KIT2.36781292
9SYK2.35654598
10MAP3K142.32403024
11RIPK42.31593253
12BTK2.19415763
13GRK62.13629547
14JAK31.98975617
15TEC1.97761966
16ZAP701.86054864
17IKBKE1.85451770
18ITK1.81097321
19CSK1.71198992
20TYK21.70940699
21PINK11.70653500
22BMPR21.65299310
23IKBKB1.65257859
24LYN1.61187239
25ADRBK21.59683116
26TBK11.43366065
27MAP4K21.40469803
28JAK11.39215212
29LCK1.36465829
30MARK31.34617985
31CSF1R1.31170341
32HCK1.26582120
33GRK71.25824081
34TRPM71.21706919
35IRAK41.14987977
36TLK11.14889849
37FGR1.10080288
38MATK1.09747251
39PIK3CG1.03185098
40KDR0.98702837
41EIF2AK30.97122208
42PRKCQ0.94645439
43TESK20.92304163
44IRAK10.91932290
45MAP2K30.91810263
46FRK0.87743745
47ZAK0.84252577
48PIM10.82313431
49MAPK110.79642560
50CDK190.78175908
51TGFBR20.77270293
52TNK20.75595878
53JAK20.72457296
54MST40.67924582
55ACVR1B0.62037309
56IGF1R0.60753637
57MAPK120.60382972
58CHUK0.55864315
59CDK40.53026945
60MAP3K50.52091889
61VRK10.52007355
62MAP2K20.51976169
63ABL10.51928690
64EGFR0.50396646
65MAPK130.48660899
66EIF2AK20.40082552
67CLK10.39833733
68FYN0.39608981
69CDK60.38263128
70MAPK150.35763486
71PDK10.34661668
72RPS6KA50.34291573
73MAP3K10.33882787
74INSR0.33549043
75MAPK70.33245237
76NUAK10.33194973
77ADRBK10.33171033
78FLT30.33047375
79IRAK20.32507810
80CDK80.30416314
81GRK10.30250843
82RPS6KA40.29215054
83SGK20.28035520
84FGFR30.27843334
85MAPKAPK30.25964111
86IRAK30.25753851
87STK100.25738804
88MAP3K110.24936211
89OBSCN0.24654759
90ERBB20.24422848
91CAMK40.24238793
92HIPK20.24207202
93PTK2B0.22820621
94PRKD20.22676079
95TAOK10.22513540
96MAPK30.21521461
97ERBB30.17257244
98SIK20.16483829
99MAPK40.16151902
100MAP3K30.15828278

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.95596511
2Asthma_Homo sapiens_hsa053103.83262439
3Allograft rejection_Homo sapiens_hsa053303.71952510
4Autoimmune thyroid disease_Homo sapiens_hsa053203.56225987
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.40236281
6Primary immunodeficiency_Homo sapiens_hsa053403.23881565
7Staphylococcus aureus infection_Homo sapiens_hsa051502.81686268
8Type I diabetes mellitus_Homo sapiens_hsa049402.79890305
9Leishmaniasis_Homo sapiens_hsa051402.72834141
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.66964668
11Antigen processing and presentation_Homo sapiens_hsa046122.52670614
12Hematopoietic cell lineage_Homo sapiens_hsa046402.13796484
13Rheumatoid arthritis_Homo sapiens_hsa053232.09725477
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08244489
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.03280361
16Osteoclast differentiation_Homo sapiens_hsa043801.95109330
17B cell receptor signaling pathway_Homo sapiens_hsa046621.94186362
18Viral myocarditis_Homo sapiens_hsa054161.85806902
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85743480
20T cell receptor signaling pathway_Homo sapiens_hsa046601.75483450
21Tuberculosis_Homo sapiens_hsa051521.67474707
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65612433
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51002530
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47675986
25Measles_Homo sapiens_hsa051621.43764294
26Toxoplasmosis_Homo sapiens_hsa051451.40372574
27Herpes simplex infection_Homo sapiens_hsa051681.38932808
28Legionellosis_Homo sapiens_hsa051341.30954480
29Malaria_Homo sapiens_hsa051441.27600235
30Influenza A_Homo sapiens_hsa051641.24879782
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20514854
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.17392314
33Chemokine signaling pathway_Homo sapiens_hsa040621.13973464
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10767850
35Systemic lupus erythematosus_Homo sapiens_hsa053221.09434403
36Platelet activation_Homo sapiens_hsa046111.06959778
37Phagosome_Homo sapiens_hsa041451.03368824
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03284250
39TNF signaling pathway_Homo sapiens_hsa046681.00533916
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99493117
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98857138
42Pertussis_Homo sapiens_hsa051330.92361695
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91116549
44Other glycan degradation_Homo sapiens_hsa005110.84866705
45Apoptosis_Homo sapiens_hsa042100.81609820
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80689624
47Hepatitis B_Homo sapiens_hsa051610.74612946
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71489165
49Olfactory transduction_Homo sapiens_hsa047400.69271509
50Epstein-Barr virus infection_Homo sapiens_hsa051690.68116746
51Acute myeloid leukemia_Homo sapiens_hsa052210.65794652
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59973562
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.55439301
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55125936
55Lysosome_Homo sapiens_hsa041420.54185250
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53280133
57HTLV-I infection_Homo sapiens_hsa051660.52432442
58African trypanosomiasis_Homo sapiens_hsa051430.52142267
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.50006650
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48588343
61Shigellosis_Homo sapiens_hsa051310.48492523
62Non-small cell lung cancer_Homo sapiens_hsa052230.47387607
63Regulation of autophagy_Homo sapiens_hsa041400.46997815
64Phototransduction_Homo sapiens_hsa047440.43237559
65Dorso-ventral axis formation_Homo sapiens_hsa043200.42822393
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41795402
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39742217
68Salmonella infection_Homo sapiens_hsa051320.37779493
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35738019
70Viral carcinogenesis_Homo sapiens_hsa052030.33860517
71Salivary secretion_Homo sapiens_hsa049700.32762946
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31932682
73Arachidonic acid metabolism_Homo sapiens_hsa005900.31798734
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31461846
75FoxO signaling pathway_Homo sapiens_hsa040680.31063770
76Linoleic acid metabolism_Homo sapiens_hsa005910.30498111
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30406246
78Chemical carcinogenesis_Homo sapiens_hsa052040.29415342
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29157165
80Ovarian steroidogenesis_Homo sapiens_hsa049130.29013359
81Hepatitis C_Homo sapiens_hsa051600.27511738
82Fanconi anemia pathway_Homo sapiens_hsa034600.27237315
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27191053
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25343645
85Collecting duct acid secretion_Homo sapiens_hsa049660.21740295
86Renin secretion_Homo sapiens_hsa049240.20255094
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18028492
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.17753215
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.16742531
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15955145
91Prolactin signaling pathway_Homo sapiens_hsa049170.14817770
92Taste transduction_Homo sapiens_hsa047420.14546147
93Nitrogen metabolism_Homo sapiens_hsa009100.13839404
94Pancreatic cancer_Homo sapiens_hsa052120.13600690
95Oxytocin signaling pathway_Homo sapiens_hsa049210.13048684
96MAPK signaling pathway_Homo sapiens_hsa040100.12998614
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.12971417
98Ether lipid metabolism_Homo sapiens_hsa005650.12833642
99Calcium signaling pathway_Homo sapiens_hsa040200.12568095
100Homologous recombination_Homo sapiens_hsa034400.11677244

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