ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.08042815
2	cell proliferation in forebrain (GO:0021846)	4.69857073
3	DNA deamination (GO:0045006)	4.09006050
4	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64561285
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64561285
6	NADH dehydrogenase complex assembly (GO:0010257)	3.64561285
7	sulfation (GO:0051923)	3.63831316
8	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.61617918
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.61211783
10	tryptophan catabolic process (GO:0006569)	3.47672339
11	indole-containing compound catabolic process (GO:0042436)	3.47672339
12	indolalkylamine catabolic process (GO:0046218)	3.47672339
13	kynurenine metabolic process (GO:0070189)	3.45952004
14	regulation of cilium movement (GO:0003352)	3.41620936
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41223008
16	somite development (GO:0061053)	3.36663157
17	protein complex biogenesis (GO:0070271)	3.34551836
18	parturition (GO:0007567)	3.30641446
19	adaptation of signaling pathway (GO:0023058)	3.28667278
20	protein polyglutamylation (GO:0018095)	3.21461567
21	cellular response to ATP (GO:0071318)	3.18292545
22	indolalkylamine metabolic process (GO:0006586)	3.14121063
23	negative regulation of mast cell activation (GO:0033004)	3.11523180
24	fucose catabolic process (GO:0019317)	3.08466843
25	L-fucose metabolic process (GO:0042354)	3.08466843
26	L-fucose catabolic process (GO:0042355)	3.08466843
27	regulation of microtubule-based movement (GO:0060632)	3.07659203
28	dentate gyrus development (GO:0021542)	3.05553106
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03510526
30	negative regulation of telomere maintenance (GO:0032205)	3.03098789
31	protein neddylation (GO:0045116)	3.02453644
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.01726768
33	tryptophan metabolic process (GO:0006568)	2.89168326
34	negative regulation of response to food (GO:0032096)	2.88916443
35	negative regulation of appetite (GO:0032099)	2.88916443
36	regulation of mesoderm development (GO:2000380)	2.88475418
37	negative regulation of systemic arterial blood pressure (GO:0003085)	2.85496085
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83542789
39	endoderm formation (GO:0001706)	2.83255112
40	detection of light stimulus involved in visual perception (GO:0050908)	2.80195662
41	detection of light stimulus involved in sensory perception (GO:0050962)	2.80195662
42	cellular biogenic amine catabolic process (GO:0042402)	2.79904949
43	amine catabolic process (GO:0009310)	2.79904949
44	tongue development (GO:0043586)	2.75077316
45	cellular response to exogenous dsRNA (GO:0071360)	2.74802150
46	regulation of germinal center formation (GO:0002634)	2.67202537
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.65309353
48	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.64992951
49	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.64608512
50	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63454944
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63416693
52	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.63077572
53	membrane repolarization during action potential (GO:0086011)	2.61285987
54	magnesium ion transport (GO:0015693)	2.55976476
55	positive regulation of defense response to virus by host (GO:0002230)	2.55103790
56	synaptic transmission, cholinergic (GO:0007271)	2.54885040
57	epithelial cilium movement (GO:0003351)	2.54733319
58	platelet dense granule organization (GO:0060155)	2.50349642
59	positive regulation of T cell apoptotic process (GO:0070234)	2.49048306
60	axoneme assembly (GO:0035082)	2.47513245
61	negative regulation of T cell differentiation in thymus (GO:0033085)	2.46171663
62	cardiovascular system development (GO:0072358)	2.46162842
63	negative regulation of astrocyte differentiation (GO:0048712)	2.45784832
64	mannosylation (GO:0097502)	2.45445022
65	gamma-aminobutyric acid transport (GO:0015812)	2.44687788
66	NAD biosynthetic process (GO:0009435)	2.42800453
67	cellular anion homeostasis (GO:0030002)	2.40804809
68	substrate-independent telencephalic tangential migration (GO:0021826)	2.39053526
69	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.39053526
70	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.38517009
71	kidney morphogenesis (GO:0060993)	2.36334154
72	neuronal action potential (GO:0019228)	2.36262345
73	membrane depolarization during action potential (GO:0086010)	2.31187627
74	chaperone-mediated protein transport (GO:0072321)	2.30728156
75	lysosome localization (GO:0032418)	2.29437848
76	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.28956975
77	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.28591037
78	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.27838276
79	positive regulation of fatty acid transport (GO:2000193)	2.27655668
80	transmission of nerve impulse (GO:0019226)	2.27539846
81	regulation of gene silencing by RNA (GO:0060966)	2.27533103
82	regulation of posttranscriptional gene silencing (GO:0060147)	2.27533103
83	regulation of gene silencing by miRNA (GO:0060964)	2.27533103
84	positive regulation of cAMP-mediated signaling (GO:0043950)	2.27510447
85	indole-containing compound metabolic process (GO:0042430)	2.27464158
86	nonmotile primary cilium assembly (GO:0035058)	2.26916808
87	N-acetylglucosamine metabolic process (GO:0006044)	2.26278912
88	photoreceptor cell development (GO:0042461)	2.25683260
89	positive regulation of fatty acid oxidation (GO:0046321)	2.25572341
90	piRNA metabolic process (GO:0034587)	2.25471705
91	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.25425578
92	pituitary gland development (GO:0021983)	2.25182349
93	DNA methylation involved in gamete generation (GO:0043046)	2.24939251
94	GPI anchor metabolic process (GO:0006505)	2.24869339
95	head development (GO:0060322)	2.24605400
96	negative regulation of Rho protein signal transduction (GO:0035024)	2.24529406
97	pyrimidine nucleobase catabolic process (GO:0006208)	2.24507841
98	regulation of thymocyte apoptotic process (GO:0070243)	2.24143480
99	regulation of sequestering of triglyceride (GO:0010889)	2.22890753
100	regulation of glomerulus development (GO:0090192)	2.22443595

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.18189709
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81688271
3	VDR_22108803_ChIP-Seq_LS180_Human	2.77150336
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.69432028
5	IRF1_19129219_ChIP-ChIP_H3396_Human	2.43010635
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.14741461
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.11695745
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09297013
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.03726269
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.98877221
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88668375
12	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86770837
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85685019
14	REST_21632747_ChIP-Seq_MESCs_Mouse	1.85366278
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84752952
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.83881974
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83385497
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75281935
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69008997
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68357988
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.67998847
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.64303728
23	EWS_26573619_Chip-Seq_HEK293_Human	1.64119469
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.59962179
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59064747
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58857464
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.58753637
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.57260113
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56197856
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53669009
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51092789
32	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.50335116
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49019978
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48207142
35	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.46674723
36	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.45640973
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44925715
38	P300_19829295_ChIP-Seq_ESCs_Human	1.44583757
39	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42217707
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41116804
41	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.39188333
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.36795787
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36323240
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36323240
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.35026813
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32519713
47	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31721206
48	FUS_26573619_Chip-Seq_HEK293_Human	1.30519317
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28544545
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.27656985
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27368310
52	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27284776
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26565392
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24771618
55	NCOR_22424771_ChIP-Seq_293T_Human	1.23435563
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23155803
57	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18091596
58	* CBP_20019798_ChIP-Seq_JUKART_Human	1.18091596
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17889549
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17022865
61	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15763658
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14927040
63	STAT3_23295773_ChIP-Seq_U87_Human	1.14302756
64	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14083321
65	TCF4_23295773_ChIP-Seq_U87_Human	1.12396357
66	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.11889984
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11420034
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11420034
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11141311
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09974403
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.09406034
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.09086194
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08391680
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06683634
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06486087
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05948327
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.05624186
78	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.05624186
79	AR_25329375_ChIP-Seq_VCAP_Human	1.04376775
80	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04312299
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04263416
82	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03577311
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03403101
84	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02610811
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.02468602
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.02302305
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00912114
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00165086
89	ERA_21632823_ChIP-Seq_H3396_Human	0.99082653
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98769670
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.98722756
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97248262
93	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.96236767
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95864351
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95753964
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.95531884
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94418443
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94374879
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93699877
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92620994

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.52610247
2	MP0002653_abnormal_ependyma_morphology	2.59846073
3	MP0001986_abnormal_taste_sensitivity	2.53319143
4	MP0005646_abnormal_pituitary_gland	2.36859724
5	MP0008877_abnormal_DNA_methylation	2.33452552
6	MP0002876_abnormal_thyroid_physiology	2.26783702
7	MP0003787_abnormal_imprinting	2.23570207
8	MP0000569_abnormal_digit_pigmentation	2.23408038
9	MP0004885_abnormal_endolymph	2.19608206
10	MP0003646_muscle_fatigue	2.17493344
11	MP0001485_abnormal_pinna_reflex	2.16751871
12	MP0002837_dystrophic_cardiac_calcinosis	1.99120702
13	MP0002138_abnormal_hepatobiliary_system	1.97673960
14	MP0005551_abnormal_eye_electrophysiolog	1.95751368
15	MP0005174_abnormal_tail_pigmentation	1.91890684
16	MP0002102_abnormal_ear_morphology	1.90021879
17	MP0000631_abnormal_neuroendocrine_gland	1.86783737
18	MP0003136_yellow_coat_color	1.85648162
19	MP0008789_abnormal_olfactory_epithelium	1.81942706
20	MP0001968_abnormal_touch/_nociception	1.81704245
21	MP0004142_abnormal_muscle_tone	1.80932066
22	MP0002638_abnormal_pupillary_reflex	1.78303703
23	MP0002272_abnormal_nervous_system	1.75950663
24	MP0002163_abnormal_gland_morphology	1.65684551
25	MP0004133_heterotaxia	1.62247365
26	MP0004130_abnormal_muscle_cell	1.58966040
27	MP0009745_abnormal_behavioral_response	1.58752091
28	MP0008872_abnormal_physiological_respon	1.54871882
29	MP0009379_abnormal_foot_pigmentation	1.53238930
30	MP0003195_calcinosis	1.44761269
31	MP0003878_abnormal_ear_physiology	1.44496485
32	MP0005377_hearing/vestibular/ear_phenot	1.44496485
33	MP0004145_abnormal_muscle_electrophysio	1.39708157
34	MP0000049_abnormal_middle_ear	1.38527949
35	MP0006072_abnormal_retinal_apoptosis	1.36488057
36	MP0003724_increased_susceptibility_to	1.36349438
37	MP0002733_abnormal_thermal_nociception	1.33414270
38	MP0005671_abnormal_response_to	1.30991272
39	MP0005423_abnormal_somatic_nervous	1.29013943
40	MP0002938_white_spotting	1.28728142
41	MP0004742_abnormal_vestibular_system	1.28635625
42	MP0002160_abnormal_reproductive_system	1.28502737
43	MP0000015_abnormal_ear_pigmentation	1.27686688
44	MP0005394_taste/olfaction_phenotype	1.26256263
45	MP0005499_abnormal_olfactory_system	1.26256263
46	MP0009046_muscle_twitch	1.21873318
47	MP0005389_reproductive_system_phenotype	1.21608508
48	MP0001501_abnormal_sleep_pattern	1.19784908
49	MP0001970_abnormal_pain_threshold	1.19114855
50	MP0001440_abnormal_grooming_behavior	1.18723414
51	MP0002557_abnormal_social/conspecific_i	1.18406235
52	MP0006276_abnormal_autonomic_nervous	1.14490987
53	MP0002572_abnormal_emotion/affect_behav	1.12829005
54	MP0008775_abnormal_heart_ventricle	1.12272497
55	MP0002064_seizures	1.12212169
56	MP0005195_abnormal_posterior_eye	1.11187786
57	MP0003879_abnormal_hair_cell	1.10752521
58	MP0002735_abnormal_chemical_nociception	1.09567109
59	MP0005084_abnormal_gallbladder_morpholo	1.08781222
60	MP0002095_abnormal_skin_pigmentation	1.06991646
61	MP0003011_delayed_dark_adaptation	1.05064186
62	MP0005645_abnormal_hypothalamus_physiol	1.04292114
63	MP0000026_abnormal_inner_ear	1.04183631
64	MP0003880_abnormal_central_pattern	1.04116547
65	MP0000778_abnormal_nervous_system	1.03406832
66	MP0002736_abnormal_nociception_after	1.02381493
67	MP0003635_abnormal_synaptic_transmissio	1.00730835
68	MP0003938_abnormal_ear_development	0.99174327
69	MP0002063_abnormal_learning/memory/cond	0.97915975
70	MP0001502_abnormal_circadian_rhythm	0.97470437
71	MP0002928_abnormal_bile_duct	0.97134137
72	MP0005253_abnormal_eye_physiology	0.96205777
73	MP0001984_abnormal_olfaction	0.96170033
74	MP0003121_genomic_imprinting	0.94655568
75	MP0005379_endocrine/exocrine_gland_phen	0.93468048
76	MP0000372_irregular_coat_pigmentation	0.92947879
77	MP0002752_abnormal_somatic_nervous	0.92806325
78	MP0001963_abnormal_hearing_physiology	0.92610032
79	MP0002067_abnormal_sensory_capabilities	0.92242484
80	MP0002184_abnormal_innervation	0.91981837
81	MP0001919_abnormal_reproductive_system	0.91130994
82	MP0005075_abnormal_melanosome_morpholog	0.90581510
83	MP0000427_abnormal_hair_cycle	0.89609532
84	MP0000230_abnormal_systemic_arterial	0.89224564
85	MP0008875_abnormal_xenobiotic_pharmacok	0.84421499
86	MP0004859_abnormal_synaptic_plasticity	0.80318964
87	MP0001905_abnormal_dopamine_level	0.79866902
88	MP0009764_decreased_sensitivity_to	0.79255094
89	MP0000955_abnormal_spinal_cord	0.78630339
90	MP0001800_abnormal_humoral_immune	0.77621511
91	MP0003122_maternal_imprinting	0.77332646
92	MP0002277_abnormal_respiratory_mucosa	0.76944673
93	MP0001188_hyperpigmentation	0.76766735
94	MP0001663_abnormal_digestive_system	0.76038849
95	MP0002229_neurodegeneration	0.75052766
96	MP0001486_abnormal_startle_reflex	0.74400796
97	MP0001293_anophthalmia	0.74083719
98	MP0000685_abnormal_immune_system	0.73003930
99	MP0001324_abnormal_eye_pigmentation	0.71105159
100	MP0009765_abnormal_xenobiotic_induced	0.70892793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.02063365
2	Pancreatic fibrosis (HP:0100732)	3.80398949
3	Nephronophthisis (HP:0000090)	3.69364590
4	Congenital stationary night blindness (HP:0007642)	3.66284460
5	True hermaphroditism (HP:0010459)	3.55115905
6	Abnormality of midbrain morphology (HP:0002418)	3.45880567
7	Molar tooth sign on MRI (HP:0002419)	3.45880567
8	Abnormality of the renal medulla (HP:0100957)	3.07200495
9	Abolished electroretinogram (ERG) (HP:0000550)	2.99852424
10	Pendular nystagmus (HP:0012043)	2.96451702
11	Absent thumb (HP:0009777)	2.71201392
12	Genetic anticipation (HP:0003743)	2.71067344
13	Type II lissencephaly (HP:0007260)	2.68094625
14	Abnormality of the renal cortex (HP:0011035)	2.62455839
15	Asplenia (HP:0001746)	2.61059147
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.60888412
17	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.59724675
18	Congenital, generalized hypertrichosis (HP:0004540)	2.56288863
19	Progressive cerebellar ataxia (HP:0002073)	2.55386153
20	Rib fusion (HP:0000902)	2.53765213
21	Abnormality of DNA repair (HP:0003254)	2.53713844
22	Medial flaring of the eyebrow (HP:0010747)	2.53532175
23	Sclerocornea (HP:0000647)	2.52990188
24	Agitation (HP:0000713)	2.39212109
25	3-Methylglutaconic aciduria (HP:0003535)	2.37556633
26	Cystic liver disease (HP:0006706)	2.35294355
27	Ectopic kidney (HP:0000086)	2.35096009
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.34548941
29	Methylmalonic acidemia (HP:0002912)	2.32268062
30	Short 1st metacarpal (HP:0010034)	2.32104131
31	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.32104131
32	Abnormal number of erythroid precursors (HP:0012131)	2.31143092
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.30858476
34	Tubular atrophy (HP:0000092)	2.28565903
35	Abnormal drinking behavior (HP:0030082)	2.23706620
36	Polydipsia (HP:0001959)	2.23706620
37	Septo-optic dysplasia (HP:0100842)	2.23472329
38	Thyroiditis (HP:0100646)	2.23044861
39	Chronic hepatic failure (HP:0100626)	2.22885730
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21519371
41	Absent/shortened dynein arms (HP:0200106)	2.21519371
42	Abnormality of the renal collecting system (HP:0004742)	2.20340054
43	Abnormality of the nasal septum (HP:0000419)	2.18449921
44	Stenosis of the external auditory canal (HP:0000402)	2.18068013
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17785324
46	Reticulocytopenia (HP:0001896)	2.16940458
47	Thyroid-stimulating hormone excess (HP:0002925)	2.14828821
48	Attenuation of retinal blood vessels (HP:0007843)	2.14716750
49	IgG deficiency (HP:0004315)	2.14430280
50	Optic nerve hypoplasia (HP:0000609)	2.11862019
51	Severe combined immunodeficiency (HP:0004430)	2.06736033
52	Gait imbalance (HP:0002141)	2.05522017
53	Furrowed tongue (HP:0000221)	2.05493798
54	Bony spicule pigmentary retinopathy (HP:0007737)	2.04559245
55	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.03732133
56	Adrenal hypoplasia (HP:0000835)	2.01780477
57	Abnormality of B cell number (HP:0010975)	1.99947852
58	Acute necrotizing encephalopathy (HP:0006965)	1.99927561
59	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.98666080
60	Mitochondrial inheritance (HP:0001427)	1.98424602
61	Methylmalonic aciduria (HP:0012120)	1.98361567
62	Abnormality of the 1st metacarpal (HP:0010009)	1.98357028
63	Polyuria (HP:0000103)	1.97895710
64	Congenital hepatic fibrosis (HP:0002612)	1.96063188
65	Abnormal respiratory epithelium morphology (HP:0012253)	1.94326477
66	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94326477
67	Increased corneal curvature (HP:0100692)	1.94188116
68	Keratoconus (HP:0000563)	1.94188116
69	Renal cortical cysts (HP:0000803)	1.93062209
70	Severe visual impairment (HP:0001141)	1.91252604
71	Tachypnea (HP:0002789)	1.90326027
72	Congenital primary aphakia (HP:0007707)	1.89312194
73	Male pseudohermaphroditism (HP:0000037)	1.88647249
74	Cerebellar dysplasia (HP:0007033)	1.87502090
75	Broad-based gait (HP:0002136)	1.85937938
76	Porencephaly (HP:0002132)	1.85804886
77	Anencephaly (HP:0002323)	1.85546191
78	Concave nail (HP:0001598)	1.84292657
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84227175
80	Abnormality of alanine metabolism (HP:0010916)	1.84227175
81	Hyperalaninemia (HP:0003348)	1.84227175
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84040748
83	Hyperthyroidism (HP:0000836)	1.82220204
84	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.81967013
85	Congenital sensorineural hearing impairment (HP:0008527)	1.81310057
86	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80613966
87	Short femoral neck (HP:0100864)	1.79717992
88	Decreased central vision (HP:0007663)	1.79383613
89	Increased CSF lactate (HP:0002490)	1.79283685
90	Inability to walk (HP:0002540)	1.79042125
91	Nephrogenic diabetes insipidus (HP:0009806)	1.78797903
92	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78065791
93	Decreased circulating renin level (HP:0003351)	1.78016120
94	Short hallux (HP:0010109)	1.77751844
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77614595
96	Optic nerve coloboma (HP:0000588)	1.77063158
97	Postaxial foot polydactyly (HP:0001830)	1.75954390
98	Gaze-evoked nystagmus (HP:0000640)	1.75743195
99	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.75123983
100	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.75036878

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.53027685
2	ADRBK2	3.38259678
3	BMPR1B	3.11646605
4	TAOK3	3.05252205
5	TLK1	3.02715764
6	GRK1	2.89177466
7	WNK4	2.80005892
8	TXK	2.43877622
9	CASK	2.33988426
10	ZAK	2.20460174
11	PINK1	1.92884272
12	ACVR1B	1.92161543
13	WNK3	1.78108123
14	NUAK1	1.73916488
15	MAPK13	1.71048794
16	PIK3CA	1.52748506
17	MAP4K2	1.52452787
18	MAP3K9	1.41573473
19	INSRR	1.36686224
20	MUSK	1.33065431
21	BCKDK	1.30859277
22	NTRK2	1.30266476
23	STK39	1.30141451
24	DYRK2	1.26500555
25	IKBKB	1.22791863
26	CAMKK2	1.08650539
27	GRK7	1.05615746
28	TEC	1.05298815
29	MAP3K4	1.05072600
30	RPS6KA6	1.01726083
31	MAPK15	1.01430309
32	ADRBK1	1.01094672
33	SGK2	0.97159565
34	SYK	0.96558035
35	MARK3	0.96166777
36	PHKG1	0.95441516
37	PHKG2	0.95441516
38	PRKCG	0.95380177
39	TGFBR1	0.94408310
40	NEK1	0.93351968
41	OXSR1	0.93059907
42	MAP2K7	0.88775833
43	STK11	0.88513302
44	KIT	0.84682869
45	CAMK1	0.84521596
46	DAPK2	0.84111370
47	ITK	0.83186422
48	TNIK	0.82066028
49	TIE1	0.80399158
50	PAK3	0.78182370
51	PLK2	0.77019081
52	STK16	0.75983421
53	GRK6	0.75417025
54	DYRK3	0.75328307
55	PRKCQ	0.74556177
56	MARK1	0.74271353
57	IKBKE	0.73691983
58	MAP4K1	0.71730202
59	SGK494	0.70849542
60	SGK223	0.70849542
61	RPS6KC1	0.68745812
62	RPS6KL1	0.68745812
63	PRKCI	0.68579637
64	NTRK3	0.68350182
65	NEK2	0.67991113
66	CSNK1G2	0.67412146
67	AKT3	0.66217534
68	SIK2	0.65148783
69	CDK8	0.65005698
70	BTK	0.64823714
71	CHUK	0.64059721
72	TNK2	0.62092657
73	FGFR2	0.61942593
74	PRKCE	0.61229249
75	PRKD2	0.59878573
76	MAP2K2	0.59721459
77	CSNK1G3	0.59524465
78	VRK1	0.59198119
79	MKNK2	0.58191019
80	PRKACA	0.57579821
81	CSNK1A1	0.56719063
82	LYN	0.53403076
83	RPS6KA5	0.52656969
84	MAP3K7	0.52286299
85	LCK	0.51475093
86	RPS6KA2	0.51039297
87	PIM1	0.50915256
88	TYRO3	0.50460702
89	CAMK4	0.49992400
90	CSNK1A1L	0.49729281
91	CSNK1G1	0.48962668
92	SGK1	0.46035906
93	NLK	0.45777194
94	GRK5	0.45098998
95	CDK19	0.45059862
96	MAPKAPK3	0.44516725
97	PKN1	0.42348084
98	TAF1	0.41670569
99	MARK2	0.40745740
100	MAP2K6	0.40381283

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78205601
2	Phototransduction_Homo sapiens_hsa04744	2.71149990
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.66891111
4	Ribosome_Homo sapiens_hsa03010	2.45227008
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.43662633
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.39175189
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.30192367
8	Nicotine addiction_Homo sapiens_hsa05033	2.13469226
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10155807
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99466913
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96928319
12	Primary immunodeficiency_Homo sapiens_hsa05340	1.96207686
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90532063
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.87606633
15	Parkinsons disease_Homo sapiens_hsa05012	1.86936162
16	RNA polymerase_Homo sapiens_hsa03020	1.85542499
17	Asthma_Homo sapiens_hsa05310	1.84163711
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73084378
19	Morphine addiction_Homo sapiens_hsa05032	1.65579083
20	Basal transcription factors_Homo sapiens_hsa03022	1.58405538
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55158989
22	Homologous recombination_Homo sapiens_hsa03440	1.55057141
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54378153
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37238835
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34421673
26	Olfactory transduction_Homo sapiens_hsa04740	1.30902601
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30723946
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25756330
29	Alzheimers disease_Homo sapiens_hsa05010	1.24894243
30	RNA degradation_Homo sapiens_hsa03018	1.24851887
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.24541901
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.21924247
33	Caffeine metabolism_Homo sapiens_hsa00232	1.20639096
34	Taste transduction_Homo sapiens_hsa04742	1.20163032
35	Butanoate metabolism_Homo sapiens_hsa00650	1.15572406
36	Huntingtons disease_Homo sapiens_hsa05016	1.13083510
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12992893
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.11438098
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10118513
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09483593
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.08864812
42	Protein export_Homo sapiens_hsa03060	1.08428037
43	Allograft rejection_Homo sapiens_hsa05330	1.08013694
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05468216
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.03215165
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.00305969
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.99153443
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.97235061
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95714387
50	Serotonergic synapse_Homo sapiens_hsa04726	0.95282716
51	Insulin secretion_Homo sapiens_hsa04911	0.95171831
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92959317
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92906754
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91982405
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91673594
56	Circadian entrainment_Homo sapiens_hsa04713	0.91468254
57	GABAergic synapse_Homo sapiens_hsa04727	0.88542302
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87721083
59	Regulation of autophagy_Homo sapiens_hsa04140	0.85911561
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.85259797
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83925879
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82504969
63	Cholinergic synapse_Homo sapiens_hsa04725	0.79253443
64	Sulfur relay system_Homo sapiens_hsa04122	0.75951369
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75856059
66	Peroxisome_Homo sapiens_hsa04146	0.75303901
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74495975
68	Retinol metabolism_Homo sapiens_hsa00830	0.69801988
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65823937
70	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64665922
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.64268106
72	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62278134
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61688351
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.61272443
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59557490
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.59369981
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57670752
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54013757
79	Cocaine addiction_Homo sapiens_hsa05030	0.53173794
80	Sulfur metabolism_Homo sapiens_hsa00920	0.51263093
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.51050586
82	Purine metabolism_Homo sapiens_hsa00230	0.50793437
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50776006
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.48487906
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48298665
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47242319
87	ABC transporters_Homo sapiens_hsa02010	0.45722867
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44952634
89	Salivary secretion_Homo sapiens_hsa04970	0.44627040
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.44370799
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43424246
92	Gastric acid secretion_Homo sapiens_hsa04971	0.43257540
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43132151
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.40888202
95	Axon guidance_Homo sapiens_hsa04360	0.39974761
96	One carbon pool by folate_Homo sapiens_hsa00670	0.38911947
97	Long-term depression_Homo sapiens_hsa04730	0.37413421
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.36709173
99	Metabolic pathways_Homo sapiens_hsa01100	0.36631847
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.36548015

RRN3P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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