RRNAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.98514903
2polyketide metabolic process (GO:0030638)6.98514903
3doxorubicin metabolic process (GO:0044598)6.98514903
4regulation of nuclear cell cycle DNA replication (GO:0033262)5.55552315
5positive regulation of DNA-dependent DNA replication (GO:2000105)4.95129904
6cellular ketone body metabolic process (GO:0046950)4.70672359
7histone H4-K12 acetylation (GO:0043983)4.67994466
8ketone body metabolic process (GO:1902224)4.57092451
9histone H4-K8 acetylation (GO:0043982)4.28007744
10histone H4-K5 acetylation (GO:0043981)4.28007744
11maintenance of protein location in nucleus (GO:0051457)4.19813647
12aminoglycoside antibiotic metabolic process (GO:0030647)4.14130852
13negative regulation of telomere maintenance (GO:0032205)4.12553101
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.94464473
15GDP-mannose metabolic process (GO:0019673)3.92717430
16cytochrome complex assembly (GO:0017004)3.91290733
17nucleoside diphosphate catabolic process (GO:0009134)3.89095682
18interferon-gamma production (GO:0032609)3.87278461
19S-adenosylmethionine metabolic process (GO:0046500)3.83331178
20homocysteine metabolic process (GO:0050667)3.77412588
21DNA deamination (GO:0045006)3.75963964
22phosphatidylethanolamine biosynthetic process (GO:0006646)3.72622428
23somite rostral/caudal axis specification (GO:0032525)3.72157996
24DNA methylation involved in gamete generation (GO:0043046)3.65571341
25C-terminal protein lipidation (GO:0006501)3.59839270
26histone H3-K4 trimethylation (GO:0080182)3.59716740
27phosphatidylethanolamine metabolic process (GO:0046337)3.58804976
28folic acid metabolic process (GO:0046655)3.56669228
29response to pheromone (GO:0019236)3.55171125
30cellular response to ATP (GO:0071318)3.53535065
31regulation of telomere maintenance (GO:0032204)3.52111172
32sulfur amino acid catabolic process (GO:0000098)3.48874564
33ribosomal small subunit biogenesis (GO:0042274)3.45282331
34regulation of MHC class I biosynthetic process (GO:0045343)3.42984063
35pyrimidine dimer repair (GO:0006290)3.40959903
36mast cell activation involved in immune response (GO:0002279)3.38064855
37mast cell degranulation (GO:0043303)3.38064855
38regulation of hydrogen peroxide metabolic process (GO:0010310)3.37997778
39regulation of response to osmotic stress (GO:0047484)3.33029077
40mannosylation (GO:0097502)3.32161283
41peptidyl-histidine modification (GO:0018202)3.27294573
42acrosome reaction (GO:0007340)3.27087038
43regulation of cilium movement (GO:0003352)3.25674909
44male meiosis I (GO:0007141)3.23799237
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19108139
46tRNA modification (GO:0006400)3.18281541
47organic cation transport (GO:0015695)3.18154820
48protein localization to cilium (GO:0061512)3.12270267
49C-terminal protein amino acid modification (GO:0018410)3.10537141
50regulation of telomere maintenance via telomerase (GO:0032210)3.10529543
51histone H4-K16 acetylation (GO:0043984)3.08230351
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07523870
53sperm motility (GO:0030317)3.07458908
54meiotic chromosome segregation (GO:0045132)3.06084824
55gonadal mesoderm development (GO:0007506)3.05709909
56endocrine pancreas development (GO:0031018)3.04914186
57cilium or flagellum-dependent cell motility (GO:0001539)3.03064025
58mannose metabolic process (GO:0006013)2.99455191
59signal peptide processing (GO:0006465)2.98620810
60negative regulation of telomerase activity (GO:0051974)2.98040151
61regulation of hexokinase activity (GO:1903299)2.97708854
62regulation of glucokinase activity (GO:0033131)2.97708854
63histone H3-K36 demethylation (GO:0070544)2.95350608
64nephron tubule morphogenesis (GO:0072078)2.95094946
65nephron epithelium morphogenesis (GO:0072088)2.95094946
66histone H3-K4 methylation (GO:0051568)2.94164142
67pseudouridine synthesis (GO:0001522)2.93944895
68tRNA methylation (GO:0030488)2.89664816
69DNA replication checkpoint (GO:0000076)2.88873713
70protein polyglutamylation (GO:0018095)2.88362918
71CENP-A containing nucleosome assembly (GO:0034080)2.88078275
72glycerophospholipid catabolic process (GO:0046475)2.86650189
73cellular extravasation (GO:0045123)2.84682849
74water-soluble vitamin biosynthetic process (GO:0042364)2.83826198
75phosphatidylglycerol biosynthetic process (GO:0006655)2.80077194
76positive regulation of histone deacetylation (GO:0031065)2.79668697
77regulation of B cell apoptotic process (GO:0002902)2.79578761
78pteridine-containing compound metabolic process (GO:0042558)2.79194931
79cardiolipin metabolic process (GO:0032048)2.79108502
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77565071
81L-phenylalanine metabolic process (GO:0006558)2.76467203
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.76467203
83regulation of DNA-dependent DNA replication (GO:0090329)2.75315525
84axoneme assembly (GO:0035082)2.75260775
85heme transport (GO:0015886)2.74952553
86positive regulation of triglyceride biosynthetic process (GO:0010867)2.74301386
87spliceosomal complex assembly (GO:0000245)2.74045536
88regulation of mitochondrial translation (GO:0070129)2.71586168
89folic acid-containing compound metabolic process (GO:0006760)2.70821705
90chromatin remodeling at centromere (GO:0031055)2.70159424
91synapsis (GO:0007129)2.69881357
92misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.68876646
93protein complex biogenesis (GO:0070271)2.68058094
94GPI anchor biosynthetic process (GO:0006506)2.67896164
95kinetochore assembly (GO:0051382)2.67801214
96L-phenylalanine catabolic process (GO:0006559)2.66018858
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66018858
98glutathione biosynthetic process (GO:0006750)2.64908791
99mast cell activation (GO:0045576)2.64516886
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64322632
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64322632
102positive regulation of glycolytic process (GO:0045821)2.64057691
103L-alpha-amino acid transmembrane transport (GO:1902475)2.60705765
104tetrahydrofolate metabolic process (GO:0046653)2.60290554
105modulation by virus of host process (GO:0019054)2.58560115
106male meiosis (GO:0007140)2.56609306
107dendritic cell chemotaxis (GO:0002407)2.55615556
108DNA damage response, detection of DNA damage (GO:0042769)2.55049622
109poly(A)+ mRNA export from nucleus (GO:0016973)2.54877260
110DNA synthesis involved in DNA repair (GO:0000731)2.53665971
111alanine transport (GO:0032328)2.53563365
112quinone metabolic process (GO:1901661)2.53129408
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.53103323
114NADH dehydrogenase complex assembly (GO:0010257)2.53103323
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53103323
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.52530950
117short-chain fatty acid metabolic process (GO:0046459)2.52339183
118regulation of cytokine production involved in inflammatory response (GO:1900015)2.50935139
119mitochondrial respiratory chain complex assembly (GO:0033108)2.50875503
120negative regulation of gluconeogenesis (GO:0045721)2.50816861
121ribonucleoprotein complex biogenesis (GO:0022613)2.50560292
122rRNA transcription (GO:0009303)2.50198358
123axonemal dynein complex assembly (GO:0070286)2.49820007
124negative regulation of execution phase of apoptosis (GO:1900118)2.49457722
125transcription from RNA polymerase I promoter (GO:0006360)2.48303299
126response to ATP (GO:0033198)2.48144958
127termination of RNA polymerase III transcription (GO:0006386)2.47789018
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.47789018
129negative regulation of epidermis development (GO:0045683)2.47665912
130piRNA metabolic process (GO:0034587)2.47385490
131negative regulation of cell aging (GO:0090344)2.46273533
132preassembly of GPI anchor in ER membrane (GO:0016254)2.45718632
133basic amino acid transport (GO:0015802)2.45306433
134negative regulation of interleukin-2 production (GO:0032703)2.44266640
135regulation of triglyceride biosynthetic process (GO:0010866)2.44261673
136* rRNA modification (GO:0000154)2.44134596
137tachykinin receptor signaling pathway (GO:0007217)2.42620192
138methionine biosynthetic process (GO:0009086)2.42316478
139meiosis I (GO:0007127)2.42287867
140pteridine-containing compound biosynthetic process (GO:0042559)2.42171549
141glycolipid biosynthetic process (GO:0009247)2.42067434
142GPI anchor metabolic process (GO:0006505)2.42016993
143positive regulation of glycogen biosynthetic process (GO:0045725)2.40749442
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39934464
145omega-hydroxylase P450 pathway (GO:0097267)2.39391333
146cornea development in camera-type eye (GO:0061303)2.39381591
147regulation of respiratory burst (GO:0060263)2.38903325
148dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.38615217
149nucleoside transmembrane transport (GO:1901642)2.38478466
150regulation of histone H3-K4 methylation (GO:0051569)2.38419344
151centriole assembly (GO:0098534)2.37994491
152positive regulation of glycogen metabolic process (GO:0070875)2.37750232
153transcription elongation from RNA polymerase I promoter (GO:0006362)2.36852439
154negative regulation of fibroblast apoptotic process (GO:2000270)2.36659000
155epithelial cell fate commitment (GO:0072148)2.36267434
156detection of light stimulus involved in sensory perception (GO:0050962)2.36185247
157detection of light stimulus involved in visual perception (GO:0050908)2.36185247
158ribosome biogenesis (GO:0042254)2.35462069
159negative regulation of fatty acid metabolic process (GO:0045922)2.35013688
160multicellular organism reproduction (GO:0032504)2.34566922
161negative regulation of cell size (GO:0045792)2.34485280
162retinol metabolic process (GO:0042572)2.34412697
163regulation of fibroblast apoptotic process (GO:2000269)2.33776239
164negative regulation of epidermal cell differentiation (GO:0045605)2.33278202
165positive regulation of protein homodimerization activity (GO:0090073)2.32605949
166regulation of synapse maturation (GO:0090128)2.32086044
167* rRNA methylation (GO:0031167)2.31477808
168presynaptic membrane assembly (GO:0097105)2.31005908
169synaptic transmission, glutamatergic (GO:0035249)2.30127345
170microtubule depolymerization (GO:0007019)2.28716771
171ventricular system development (GO:0021591)2.28331293
172nonmotile primary cilium assembly (GO:0035058)2.27478258
173positive regulation of developmental pigmentation (GO:0048087)2.27281181
174respiratory chain complex IV assembly (GO:0008535)2.26221876
175cellular component biogenesis (GO:0044085)2.25574308
176ionotropic glutamate receptor signaling pathway (GO:0035235)2.24982578
177T cell migration (GO:0072678)2.24846303
178motile cilium assembly (GO:0044458)2.23864614
179regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.22601721
180replicative senescence (GO:0090399)2.22493415
181DNA replication-independent nucleosome organization (GO:0034724)2.22153283
182DNA replication-independent nucleosome assembly (GO:0006336)2.22153283
183histone H2A acetylation (GO:0043968)2.21413962
184somatic hypermutation of immunoglobulin genes (GO:0016446)2.21175788
185somatic diversification of immune receptors via somatic mutation (GO:0002566)2.21175788
186cell proliferation in forebrain (GO:0021846)2.20979706
187negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.19837126
188regulation of rhodopsin mediated signaling pathway (GO:0022400)2.19798248
189negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.18522768
190negative regulation of translation, ncRNA-mediated (GO:0040033)2.18522768
191regulation of translation, ncRNA-mediated (GO:0045974)2.18522768
192tRNA processing (GO:0008033)2.17499000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.04206645
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.03038368
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.82241383
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.49133330
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.34868975
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.34868975
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.34868975
8E2F7_22180533_ChIP-Seq_HELA_Human3.11889866
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.99190282
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.86193901
11P68_20966046_ChIP-Seq_HELA_Human2.60410457
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.56730540
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.49791416
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47012417
15IRF1_19129219_ChIP-ChIP_H3396_Human2.40958969
16GBX2_23144817_ChIP-Seq_PC3_Human2.27254979
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27154652
18BCL6_27268052_Chip-Seq_Bcells_Human2.26298386
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22378435
20LXR_22292898_ChIP-Seq_THP-1_Human2.19094363
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18957166
22BCOR_27268052_Chip-Seq_Bcells_Human2.17933244
23ELF1_20517297_ChIP-Seq_JURKAT_Human2.17533237
24E2F1_20622854_ChIP-Seq_HELA_Human2.16997872
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15964916
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14701762
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12748227
28KDM5A_27292631_Chip-Seq_BREAST_Human2.10846741
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09887036
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.04535900
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02410114
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.98982897
33VDR_21846776_ChIP-Seq_THP-1_Human1.98829302
34PHF8_20622854_ChIP-Seq_HELA_Human1.96115502
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.93875221
36XRN2_22483619_ChIP-Seq_HELA_Human1.91685162
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89166269
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89027823
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85326798
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.84923661
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.83383889
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82187428
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.81483260
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80255340
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78752271
46* FOXP1_21924763_ChIP-Seq_HESCs_Human1.77852120
47GABP_19822575_ChIP-Seq_HepG2_Human1.76443348
48FOXP3_21729870_ChIP-Seq_TREG_Human1.75700683
49CTCF_27219007_Chip-Seq_Bcells_Human1.74653184
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.74324743
51SA1_27219007_Chip-Seq_Bcells_Human1.73395602
52ERA_21632823_ChIP-Seq_H3396_Human1.73215667
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72900511
54RACK7_27058665_Chip-Seq_MCF-7_Human1.71790924
55RNF2_27304074_Chip-Seq_NSC_Mouse1.63148037
56SMC4_20622854_ChIP-Seq_HELA_Human1.62831239
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.62272473
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60199804
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.59471823
60CTCF_20526341_ChIP-Seq_ESCs_Human1.59332781
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59156150
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58918003
63RARB_24833708_ChIP-Seq_LIVER_Mouse1.57601374
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.57203034
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.57103728
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54921841
67EZH2_22144423_ChIP-Seq_EOC_Human1.53065030
68VDR_22108803_ChIP-Seq_LS180_Human1.52513136
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51960018
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51141342
71MAF_26560356_Chip-Seq_TH2_Human1.50829625
72P300_27268052_Chip-Seq_Bcells_Human1.48022939
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47770097
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47351857
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47149707
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46690102
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45809115
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.45159774
79DCP1A_22483619_ChIP-Seq_HELA_Human1.43148124
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42946805
81CREB1_26743006_Chip-Seq_LNCaP_Human1.41947814
82OCT4_20526341_ChIP-Seq_ESCs_Human1.40831692
83RAC3_21632823_ChIP-Seq_H3396_Human1.39780863
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39697918
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.38387059
86TAF2_19829295_ChIP-Seq_ESCs_Human1.36923002
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36823312
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.36241715
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.34827472
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33541233
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.32686851
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29390861
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27505578
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26822426
95CIITA_25753668_ChIP-Seq_RAJI_Human1.26743632
96NCOR1_26117541_ChIP-Seq_K562_Human1.26627477
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24696877
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23348387
99VDR_23849224_ChIP-Seq_CD4+_Human1.23256624
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.23113601
101IGF1R_20145208_ChIP-Seq_DFB_Human1.23034779
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22895568
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22586269
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22128376
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21845419
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20407315
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20335115
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19942107
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19905118
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19521078
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.19366849
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18589275
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18488436
114CTCF_21964334_Chip-Seq_Bcells_Human1.17636421
115ZNF274_21170338_ChIP-Seq_K562_Hela1.17198936
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16709640
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16390095
118TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15010917
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.14211181
120LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13721254
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13479764
122RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13091702
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12261843
124MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12138147
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12005321
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11637552
127MYC_18555785_ChIP-Seq_MESCs_Mouse1.11565531
128P53_21459846_ChIP-Seq_SAOS-2_Human1.10964157
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10916126
130NANOG_20526341_ChIP-Seq_ESCs_Human1.10893607
131TP63_22573176_ChIP-Seq_HFKS_Human1.10588952
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10396742
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06819659
134MYC_19829295_ChIP-Seq_ESCs_Human1.05877250
135P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05859167
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05386299
137TTF2_22483619_ChIP-Seq_HELA_Human1.04272953
138TFEB_21752829_ChIP-Seq_HELA_Human1.02638817
139ELK1_19687146_ChIP-ChIP_HELA_Human1.02561401
140RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02485143
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02226175
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02226175
143NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02212272
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01817355
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01346955
146POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00945752
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.99160974
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98860622
149ZFX_18555785_Chip-Seq_ESCs_Mouse0.98370298
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98303106
151RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98224692
152JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97917490
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97334980
154MAF_26560356_Chip-Seq_TH1_Human0.97320969
155GATA1_19941826_ChIP-Seq_K562_Human0.96929631
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.96889712
157CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96705158
158SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96576180
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95636763
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95530997
161GATA1_26923725_Chip-Seq_HPCs_Mouse0.94851186
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94505053
163REST_21632747_ChIP-Seq_MESCs_Mouse0.94395802
164TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94296910
165MYC_18940864_ChIP-ChIP_HL60_Human0.93589836
166E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93255011
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.93159479
168E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91820498
169SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91015310
170SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89613954
171EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89225640
172KLF4_18555785_Chip-Seq_ESCs_Mouse0.88720371
173SOX2_16153702_ChIP-ChIP_HESCs_Human0.87940107
174SCL_19346495_ChIP-Seq_HPC-7_Human0.87103431
175SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86825669
176E2F1_18555785_Chip-Seq_ESCs_Mouse0.86269631
177MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86043856
178LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85457323
179SALL1_21062744_ChIP-ChIP_HESCs_Human0.85365643
180P300_18555785_Chip-Seq_ESCs_Mouse0.85154776
181CTCF_18555785_Chip-Seq_ESCs_Mouse0.84430886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.29348544
2MP0001188_hyperpigmentation3.08992176
3MP0005083_abnormal_biliary_tract2.95564503
4MP0005423_abnormal_somatic_nervous2.91997723
5MP0001986_abnormal_taste_sensitivity2.88135286
6MP0008875_abnormal_xenobiotic_pharmacok2.83273542
7MP0003183_abnormal_peptide_metabolism2.72905770
8MP0005394_taste/olfaction_phenotype2.46232552
9MP0005499_abnormal_olfactory_system2.46232552
10MP0005075_abnormal_melanosome_morpholog2.44244756
11MP0008058_abnormal_DNA_repair2.41122386
12MP0001661_extended_life_span2.38712228
13MP0008057_abnormal_DNA_replication2.34426360
14MP0005332_abnormal_amino_acid2.28614192
15MP0002277_abnormal_respiratory_mucosa2.26300303
16MP0005410_abnormal_fertilization2.21216341
17MP0003172_abnormal_lysosome_physiology2.11782994
18MP0000372_irregular_coat_pigmentation2.10386811
19MP0000678_abnormal_parathyroid_gland2.02482832
20MP0001944_abnormal_pancreas_morphology2.02103507
21MP0003122_maternal_imprinting1.99492775
22MP0003011_delayed_dark_adaptation1.99369887
23MP0003890_abnormal_embryonic-extraembry1.97823456
24MP0005365_abnormal_bile_salt1.96198104
25MP0005377_hearing/vestibular/ear_phenot1.94680234
26MP0003878_abnormal_ear_physiology1.94680234
27MP0003136_yellow_coat_color1.94601347
28MP0004381_abnormal_hair_follicle1.91906883
29MP0002693_abnormal_pancreas_physiology1.90659286
30MP0001764_abnormal_homeostasis1.87381533
31MP0003787_abnormal_imprinting1.84049637
32MP0002139_abnormal_hepatobiliary_system1.81263210
33MP0004019_abnormal_vitamin_homeostasis1.81134323
34MP0008995_early_reproductive_senescence1.80869465
35MP0002638_abnormal_pupillary_reflex1.79352841
36MP0005174_abnormal_tail_pigmentation1.74574563
37MP0000566_synostosis1.73283360
38MP0002928_abnormal_bile_duct1.73064235
39MP0006036_abnormal_mitochondrial_physio1.72156088
40MP0003111_abnormal_nucleus_morphology1.70923189
41MP0000015_abnormal_ear_pigmentation1.70561248
42MP0004142_abnormal_muscle_tone1.70535554
43MP0005646_abnormal_pituitary_gland1.70014277
44MP0008007_abnormal_cellular_replicative1.64399378
45MP0003938_abnormal_ear_development1.55633618
46MP0005253_abnormal_eye_physiology1.55323014
47MP0003646_muscle_fatigue1.54226153
48MP0002837_dystrophic_cardiac_calcinosis1.54144574
49MP0010329_abnormal_lipoprotein_level1.51214525
50MP0003121_genomic_imprinting1.49996878
51MP0003698_abnormal_male_reproductive1.49083685
52MP0001929_abnormal_gametogenesis1.47593470
53MP0008789_abnormal_olfactory_epithelium1.47565920
54MP0004147_increased_porphyrin_level1.46495690
55MP0003786_premature_aging1.46397801
56MP0005257_abnormal_intraocular_pressure1.45865867
57MP0010234_abnormal_vibrissa_follicle1.45408757
58MP0002909_abnormal_adrenal_gland1.44462341
59MP0005171_absent_coat_pigmentation1.44194078
60MP0002132_abnormal_respiratory_system1.43366706
61MP0010094_abnormal_chromosome_stability1.43264638
62MP0002938_white_spotting1.43180308
63MP0009379_abnormal_foot_pigmentation1.42300753
64MP0002396_abnormal_hematopoietic_system1.41294091
65MP0001919_abnormal_reproductive_system1.40683922
66MP0002653_abnormal_ependyma_morphology1.40010143
67MP0005409_darkened_coat_color1.39744084
68MP0001502_abnormal_circadian_rhythm1.39565140
69MP0005220_abnormal_exocrine_pancreas1.39306360
70MP0005451_abnormal_body_composition1.38883694
71MP0009840_abnormal_foam_cell1.38767181
72MP0001968_abnormal_touch/_nociception1.38608793
73MP0000049_abnormal_middle_ear1.37038582
74MP0000013_abnormal_adipose_tissue1.35435549
75MP0005058_abnormal_lysosome_morphology1.33086516
76MP0005551_abnormal_eye_electrophysiolog1.28689571
77MP0005360_urolithiasis1.27637310
78MP0006072_abnormal_retinal_apoptosis1.26294788
79MP0003195_calcinosis1.25362797
80MP0005671_abnormal_response_to1.23930792
81MP0002210_abnormal_sex_determination1.22659909
82MP0003880_abnormal_central_pattern1.22484476
83MP0001486_abnormal_startle_reflex1.22026972
84MP0004133_heterotaxia1.20271892
85MP0000538_abnormal_urinary_bladder1.19091321
86MP0005670_abnormal_white_adipose1.18622243
87MP0005636_abnormal_mineral_homeostasis1.18405044
88MP0002572_abnormal_emotion/affect_behav1.17074579
89MP0009643_abnormal_urine_homeostasis1.16479878
90MP0001756_abnormal_urination1.15676480
91MP0002102_abnormal_ear_morphology1.14439605
92MP0001765_abnormal_ion_homeostasis1.14270598
93MP0008877_abnormal_DNA_methylation1.13951162
94MP0002078_abnormal_glucose_homeostasis1.13707525
95MP0005085_abnormal_gallbladder_physiolo1.10309470
96MP0003763_abnormal_thymus_physiology1.09331290
97MP0002254_reproductive_system_inflammat1.08669883
98MP0002163_abnormal_gland_morphology1.08321505
99MP0003943_abnormal_hepatobiliary_system1.07383487
100MP0002876_abnormal_thyroid_physiology1.07176879
101MP0001873_stomach_inflammation1.05828321
102MP0001145_abnormal_male_reproductive1.05472246
103MP0005310_abnormal_salivary_gland1.05413915
104MP0002272_abnormal_nervous_system1.04160995
105MP0009046_muscle_twitch1.03085245
106MP0008260_abnormal_autophagy1.02286279
107MP0005389_reproductive_system_phenotype1.01567113
108MP0003693_abnormal_embryo_hatching1.01046006
109MP0002751_abnormal_autonomic_nervous0.99863371
110MP0005391_vision/eye_phenotype0.99179074
111MP0002118_abnormal_lipid_homeostasis0.98803843
112MP0000003_abnormal_adipose_tissue0.98130397
113MP0002752_abnormal_somatic_nervous0.96738372
114MP0000631_abnormal_neuroendocrine_gland0.94776291
115MP0001984_abnormal_olfaction0.94152282
116MP0006035_abnormal_mitochondrial_morpho0.93417954
117MP0000778_abnormal_nervous_system0.93198365
118MP0002184_abnormal_innervation0.92268001
119MP0005408_hypopigmentation0.91497142
120MP0002822_catalepsy0.91478376
121MP0003077_abnormal_cell_cycle0.91363002
122MP0008932_abnormal_embryonic_tissue0.90287428
123MP0008872_abnormal_physiological_respon0.90015938
124MP0000609_abnormal_liver_physiology0.89198407
125MP0000026_abnormal_inner_ear0.89189629
126MP0004043_abnormal_pH_regulation0.88570511
127MP0002249_abnormal_larynx_morphology0.88179756
128MP0000653_abnormal_sex_gland0.88120981
129MP0005367_renal/urinary_system_phenotyp0.87131761
130MP0000516_abnormal_urinary_system0.87131761
131MP0004264_abnormal_extraembryonic_tissu0.87127045
132MP0001324_abnormal_eye_pigmentation0.85798908
133MP0009745_abnormal_behavioral_response0.85114971
134MP0002127_abnormal_cardiovascular_syste0.85054514
135MP0000762_abnormal_tongue_morphology0.84473971
136MP0001835_abnormal_antigen_presentation0.84001269
137MP0000703_abnormal_thymus_morphology0.83761963
138MP0005319_abnormal_enzyme/_coenzyme0.82527658
139MP0003953_abnormal_hormone_level0.82326984
140MP0006276_abnormal_autonomic_nervous0.81934105
141MP0004145_abnormal_muscle_electrophysio0.81615440
142MP0004885_abnormal_endolymph0.80894601
143MP0001800_abnormal_humoral_immune0.80513891
144MP0004957_abnormal_blastocyst_morpholog0.80348075
145MP0000427_abnormal_hair_cycle0.79251205
146MP0002160_abnormal_reproductive_system0.79139770
147MP0005584_abnormal_enzyme/coenzyme_acti0.78004583
148MP0003635_abnormal_synaptic_transmissio0.77441556
149MP0005645_abnormal_hypothalamus_physiol0.77259063
150MP0002064_seizures0.76864586
151MP0005535_abnormal_body_temperature0.76590649
152MP0001293_anophthalmia0.75199507
153MP0002063_abnormal_learning/memory/cond0.74424654
154MP0002557_abnormal_social/conspecific_i0.72147690
155MP0003315_abnormal_perineum_morphology0.70497924
156MP0002233_abnormal_nose_morphology0.70450273
157MP0002114_abnormal_axial_skeleton0.70066367
158MP0001963_abnormal_hearing_physiology0.69052683
159MP0002075_abnormal_coat/hair_pigmentati0.68958693
160MP0005379_endocrine/exocrine_gland_phen0.68578239
161MP0001270_distended_abdomen0.68129688
162MP0001186_pigmentation_phenotype0.67796460
163MP0002095_abnormal_skin_pigmentation0.67115111
164MP0002398_abnormal_bone_marrow0.66696333
165MP0001905_abnormal_dopamine_level0.65274486
166MP0001286_abnormal_eye_development0.65192955
167MP0010386_abnormal_urinary_bladder0.65100286

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.60641462
2Chromsome breakage (HP:0040012)4.89626503
3Bilateral microphthalmos (HP:0007633)3.87722782
4Duplicated collecting system (HP:0000081)3.57974236
5Squamous cell carcinoma (HP:0002860)3.30502994
6Abnormality of the renal collecting system (HP:0004742)3.29984328
7Ketoacidosis (HP:0001993)3.19914620
8Congenital stationary night blindness (HP:0007642)3.13673412
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.06737975
10Meckel diverticulum (HP:0002245)3.02175986
11Large for gestational age (HP:0001520)2.93238247
12Abnormality of the ileum (HP:0001549)2.88867064
13Nephroblastoma (Wilms tumor) (HP:0002667)2.83495749
14Ketosis (HP:0001946)2.83105127
15Acute lymphatic leukemia (HP:0006721)2.82176157
16Prostate neoplasm (HP:0100787)2.80999144
17Type I transferrin isoform profile (HP:0003642)2.77986592
18Hepatocellular necrosis (HP:0001404)2.76954422
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75764042
20Abnormality of the preputium (HP:0100587)2.73482726
21Mitochondrial inheritance (HP:0001427)2.73083958
22Hepatic necrosis (HP:0002605)2.72759281
23Hypoplasia of the fovea (HP:0007750)2.72198566
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.72198566
253-Methylglutaconic aciduria (HP:0003535)2.70907273
26Microvesicular hepatic steatosis (HP:0001414)2.69261973
27Hyperthyroidism (HP:0000836)2.69244641
28Embryonal renal neoplasm (HP:0011794)2.66559200
29Febrile seizures (HP:0002373)2.64345509
30Hypochromic microcytic anemia (HP:0004840)2.63298942
31Hyperinsulinemic hypoglycemia (HP:0000825)2.62252129
32Severe visual impairment (HP:0001141)2.59967197
33Nephronophthisis (HP:0000090)2.59812493
34Chronic hepatic failure (HP:0100626)2.59767950
35Abnormality of homocysteine metabolism (HP:0010919)2.59403012
36Homocystinuria (HP:0002156)2.59403012
37Clubbing of toes (HP:0100760)2.52173998
38Bifid tongue (HP:0010297)2.49403880
39Duplication of thumb phalanx (HP:0009942)2.46257448
40Acute necrotizing encephalopathy (HP:0006965)2.45541039
41Anomalous pulmonary venous return (HP:0010772)2.45130446
42Tubular atrophy (HP:0000092)2.43339437
43Truncus arteriosus (HP:0001660)2.42602972
44Absent thumb (HP:0009777)2.41057005
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40949611
46Cutaneous melanoma (HP:0012056)2.38892384
47Partial duplication of thumb phalanx (HP:0009944)2.37029684
48Neoplasm of the adrenal cortex (HP:0100641)2.36608576
49Reduced antithrombin III activity (HP:0001976)2.35708736
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.35461414
51Absent/shortened dynein arms (HP:0200106)2.35461414
52Acute encephalopathy (HP:0006846)2.35142943
53Molar tooth sign on MRI (HP:0002419)2.34855730
54Abnormality of midbrain morphology (HP:0002418)2.34855730
55Increased CSF lactate (HP:0002490)2.33771097
56Tented upper lip vermilion (HP:0010804)2.33453472
57Stridor (HP:0010307)2.33146432
58Abnormal mitochondria in muscle tissue (HP:0008316)2.31205533
59Progressive macrocephaly (HP:0004481)2.30941403
60Lipid accumulation in hepatocytes (HP:0006561)2.29919851
61Pendular nystagmus (HP:0012043)2.28480671
62Bony spicule pigmentary retinopathy (HP:0007737)2.26400169
63Stomach cancer (HP:0012126)2.26134244
64Hypokinesia (HP:0002375)2.26023102
65Polydipsia (HP:0001959)2.24839730
66Abnormal drinking behavior (HP:0030082)2.24839730
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23039612
68Aplastic anemia (HP:0001915)2.22098436
69Ependymoma (HP:0002888)2.21974084
70Pancreatic fibrosis (HP:0100732)2.18787166
71Methylmalonic aciduria (HP:0012120)2.17737570
72Rib fusion (HP:0000902)2.16406613
73Pancreatic cysts (HP:0001737)2.16341056
74Dicarboxylic aciduria (HP:0003215)2.15524571
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15524571
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14818297
77Septo-optic dysplasia (HP:0100842)2.13214673
78Abnormal lung lobation (HP:0002101)2.12970825
79Medulloblastoma (HP:0002885)2.12847632
80Abnormality of secondary sexual hair (HP:0009888)2.12838117
81Abnormality of the axillary hair (HP:0100134)2.12838117
82Facial cleft (HP:0002006)2.12640953
83Supernumerary spleens (HP:0009799)2.12536384
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11273513
85Abnormality of urine glucose concentration (HP:0011016)2.10921730
86Glycosuria (HP:0003076)2.10921730
87Abnormal respiratory motile cilium morphology (HP:0005938)2.10536274
88Abnormal respiratory epithelium morphology (HP:0012253)2.10536274
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.09593878
90Renal Fanconi syndrome (HP:0001994)2.07484724
91Birth length less than 3rd percentile (HP:0003561)2.05205758
92Agammaglobulinemia (HP:0004432)2.04571630
93Optic disc pallor (HP:0000543)2.03636759
94Abnormality of the pupil (HP:0000615)2.01497199
95Severe muscular hypotonia (HP:0006829)2.00808780
96Widely patent fontanelles and sutures (HP:0004492)2.00663205
97Abnormality of the pulmonary veins (HP:0011718)2.00155951
98Progressive microcephaly (HP:0000253)2.00018765
99Panhypogammaglobulinemia (HP:0003139)1.99937408
100Abnormality of chromosome stability (HP:0003220)1.99496637
101Hypoalbuminemia (HP:0003073)1.98915981
102Abnormal albumin level (HP:0012116)1.98915981
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98508849
104Nasolacrimal duct obstruction (HP:0000579)1.98266758
105Cystic liver disease (HP:0006706)1.97298750
106Nasal polyposis (HP:0100582)1.95690556
107Bone marrow hypocellularity (HP:0005528)1.95446659
108Abnormality of the fovea (HP:0000493)1.95099716
109Anterior segment dysgenesis (HP:0007700)1.94693055
110Triphalangeal thumb (HP:0001199)1.94590258
111Small intestinal stenosis (HP:0012848)1.94323660
112Duodenal stenosis (HP:0100867)1.94323660
113Hyperventilation (HP:0002883)1.93663666
114Abnormality of the renal medulla (HP:0100957)1.92742482
115Vaginal fistula (HP:0004320)1.92272747
116Abnormality of DNA repair (HP:0003254)1.91406865
117Diminished movement (HP:0002374)1.91402592
118Abnormality of the pons (HP:0007361)1.91362407
119Increased muscle lipid content (HP:0009058)1.91284259
120Methylmalonic acidemia (HP:0002912)1.90729612
121Dyschromatopsia (HP:0007641)1.89988360
122Delayed CNS myelination (HP:0002188)1.89960597
123Hypoplasia of the pons (HP:0012110)1.89872775
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89565379
125Increased hepatocellular lipid droplets (HP:0006565)1.89504939
126Myopathic facies (HP:0002058)1.89248909
127Protruding tongue (HP:0010808)1.89120467
128Partial duplication of the phalanx of hand (HP:0009999)1.88155432
129Abnormal rod and cone electroretinograms (HP:0008323)1.87712743
130Intestinal fistula (HP:0100819)1.87694230
131Cheilitis (HP:0100825)1.86510546
132Poor suck (HP:0002033)1.86058422
133Occipital encephalocele (HP:0002085)1.85101177
134Rectal fistula (HP:0100590)1.84047396
135Rectovaginal fistula (HP:0000143)1.84047396
136Aganglionic megacolon (HP:0002251)1.82282704
137Supernumerary bones of the axial skeleton (HP:0009144)1.81598344
138True hermaphroditism (HP:0010459)1.81554734
139Scrotal hypoplasia (HP:0000046)1.80891317
140Abnormality of renal excretion (HP:0011036)1.80795459
141Abnormality of the prostate (HP:0008775)1.80524693
142Cleft eyelid (HP:0000625)1.79400404
143Sclerocornea (HP:0000647)1.79111123
144Cerebellar dysplasia (HP:0007033)1.78728356
145Congenital sensorineural hearing impairment (HP:0008527)1.78439340
146Respiratory failure (HP:0002878)1.77307101
147Abnormality of the lacrimal duct (HP:0011481)1.77301822
148Meningocele (HP:0002435)1.77186956
149Epileptic encephalopathy (HP:0200134)1.77095674
150Abnormal urine output (HP:0012590)1.76464849
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.76238414
152Rhabdomyosarcoma (HP:0002859)1.75835209
153Constricted visual fields (HP:0001133)1.75702519
154Abnormal ciliary motility (HP:0012262)1.75547152
155Type II lissencephaly (HP:0007260)1.75369307
156Hypoglycemic coma (HP:0001325)1.74796394
157Broad-based gait (HP:0002136)1.74255917
158Late onset (HP:0003584)1.74017308
159Abnormality of endocrine pancreas physiology (HP:0012093)1.73924930
160Abnormality of the pancreatic islet cells (HP:0006476)1.73924930
161Attenuation of retinal blood vessels (HP:0007843)1.73389606
162Embryonal neoplasm (HP:0002898)1.73294784
163Abnormal hair whorl (HP:0010721)1.72015246
164Optic nerve hypoplasia (HP:0000609)1.71583354
165Abnormality of polysaccharide metabolism (HP:0011012)1.71415382
166Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71415382
167Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71415382
168Myelodysplasia (HP:0002863)1.70359603
169Thyroid-stimulating hormone excess (HP:0002925)1.69519117
170Cerebral edema (HP:0002181)1.69387167
171Atelectasis (HP:0100750)1.68696735
172Testicular atrophy (HP:0000029)1.67929197
173Abnormality of the nasolacrimal system (HP:0000614)1.66634454
174Retrobulbar optic neuritis (HP:0100654)1.66405897
175Optic neuritis (HP:0100653)1.66405897
176Neoplasm of striated muscle (HP:0009728)1.66077834
177Reticulocytopenia (HP:0001896)1.65890019
178Supernumerary ribs (HP:0005815)1.65711583
179Progressive external ophthalmoplegia (HP:0000590)1.64391885
180Increased IgM level (HP:0003496)1.61044340
181Abnormal biliary tract physiology (HP:0012439)1.59384452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.32766357
2PIK3CG4.46907274
3FRK3.92577592
4ADRBK23.21262790
5CDK123.08224495
6IRAK32.86974464
7SIK22.65660967
8TNIK2.52173945
9GRK12.48088548
10STK162.41268446
11GRK52.40153527
12TRIB32.35322366
13ERN12.33448188
14INSRR2.28383544
15BRD42.24584261
16IRAK42.17502913
17SRPK12.13982401
18ZAK2.11175076
19FGFR21.91510645
20PHKG11.90580169
21PHKG21.90580169
22NME11.84325685
23GRK71.83468253
24SIK11.81054326
25MAP3K141.79353254
26AKT31.78270461
27TAOK31.77934401
28GRK61.77923511
29MAP3K21.77859130
30MAPK71.76688941
31IRAK21.73619215
32NTRK31.71644826
33CDK31.65017365
34PRKD31.64696217
35WNK41.62890932
36TXK1.61842666
37TLK11.58924324
38CSF1R1.55835945
39IRAK11.53708713
40EIF2AK21.52312190
41CASK1.51551583
42TAF11.50200135
43BCKDK1.48173586
44VRK11.45376882
45MKNK21.45186923
46CLK11.43187172
47PRKD21.40870032
48PRPF4B1.40484644
49KIT1.38387812
50MAP3K101.38118858
51TTK1.32473303
52YES11.28256562
53VRK21.27721770
54MAPKAPK31.26019265
55MAP4K21.25863005
56SMG11.20947778
57TGFBR21.15939228
58MARK21.09730499
59PLK41.08886521
60MAP2K71.07657875
61MAP4K11.07219205
62MATK1.06354482
63BMPR21.05386789
64DAPK21.03712524
65PNCK1.02744725
66CDK71.01641175
67KSR21.00722861
68MST1R1.00511973
69TSSK60.97804061
70CAMK40.95506165
71MAPK110.95054732
72MAP3K30.92799920
73NEK20.92526040
74PLK10.91418332
75IKBKB0.87955354
76DYRK1A0.86389741
77PRKAA10.84792105
78TNK20.84454245
79MARK10.83801021
80MAP2K20.83084656
81NEK60.83067654
82BRSK20.82401453
83WEE10.81775653
84FLT30.80699550
85WNK10.78303345
86MKNK10.77295501
87NME20.77049658
88CSNK1G30.76084696
89PDPK10.75679459
90RIPK40.74552119
91MAP3K110.74038158
92CHEK20.73495579
93MAPKAPK50.73031312
94CDC42BPA0.72385960
95PINK10.72151363
96MARK30.70792684
97MAP3K10.70552223
98ATR0.69810228
99PTK60.69368418
100STK110.67610690
101PRKAA20.65962922
102EIF2AK30.65157467
103CSNK1G10.64545849
104CDK80.63439044
105MAP2K60.62006607
106STK380.61133253
107MAPK130.60784967
108MAP3K130.59557295
109BRSK10.59176351
110CHEK10.58155581
111MAP2K10.57870144
112DAPK10.57533421
113TEC0.57234112
114MUSK0.57215401
115PASK0.56411437
116TRIM280.55683298
117EPHA40.54888807
118ADRBK10.54806448
119CAMK2B0.54718612
120EEF2K0.54165393
121TYK20.54110241
122FGFR30.52990942
123BMPR1B0.52571233
124FES0.51779533
125RPS6KA50.51258627
126TBK10.47961911
127PKN10.47074948
128OXSR10.46624020
129PDK10.46365831
130MAP2K30.46263142
131PRKCZ0.44287793
132MAPK120.44113750
133PRKG20.43677209
134ACVR1B0.43510218
135CSNK1A10.43142202
136ATM0.42889765
137MAP3K70.42684180
138SIK30.41928414
139KSR10.41753364
140CAMK10.40614181
141HIPK20.40466362
142LCK0.39903755
143CHUK0.39159387
144LYN0.38845524
145PAK30.38183670
146PDK20.38126622
147NTRK20.37827524
148EPHA20.36855930
149PRKCI0.35725407
150NLK0.35700561
151CSNK1G20.35617175
152MAP2K40.35398262
153DYRK30.35195350
154AURKA0.34954664
155BTK0.30259860
156CDK10.29133193
157IGF1R0.28561912
158PRKCD0.28038833
159DYRK20.27090599
160SGK20.26891142
161CSK0.26510968
162PRKCG0.26424084
163BLK0.26108075
164EIF2AK10.25642843
165SYK0.25445019
166GSK3B0.25423632
167PRKG10.24559724

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.65985544
2Fanconi anemia pathway_Homo sapiens_hsa034603.48332199
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.73979207
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67943187
5Ribosome_Homo sapiens_hsa030102.66215320
6RNA polymerase_Homo sapiens_hsa030202.62213082
7Homologous recombination_Homo sapiens_hsa034402.38630671
8Mismatch repair_Homo sapiens_hsa034302.31282044
9Phototransduction_Homo sapiens_hsa047442.30215361
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18585944
11Sulfur metabolism_Homo sapiens_hsa009202.11917984
12Nicotine addiction_Homo sapiens_hsa050332.05550208
13Vitamin B6 metabolism_Homo sapiens_hsa007502.05339131
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.00795609
15Butanoate metabolism_Homo sapiens_hsa006502.00283362
16Primary immunodeficiency_Homo sapiens_hsa053401.85941805
17DNA replication_Homo sapiens_hsa030301.84513728
18RNA degradation_Homo sapiens_hsa030181.81619302
19Arachidonic acid metabolism_Homo sapiens_hsa005901.78536021
20Spliceosome_Homo sapiens_hsa030401.76215856
21Basal transcription factors_Homo sapiens_hsa030221.72813548
22Non-homologous end-joining_Homo sapiens_hsa034501.68410315
23Arginine biosynthesis_Homo sapiens_hsa002201.63577968
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59492973
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58955963
26Pyrimidine metabolism_Homo sapiens_hsa002401.58655948
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57251947
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55820814
29Graft-versus-host disease_Homo sapiens_hsa053321.54522866
30Nucleotide excision repair_Homo sapiens_hsa034201.49249182
31ABC transporters_Homo sapiens_hsa020101.44473252
32Folate biosynthesis_Homo sapiens_hsa007901.42424758
33Collecting duct acid secretion_Homo sapiens_hsa049661.41565238
34Taste transduction_Homo sapiens_hsa047421.36173507
35Selenocompound metabolism_Homo sapiens_hsa004501.35948583
36Base excision repair_Homo sapiens_hsa034101.35211511
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34187546
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34156789
39Linoleic acid metabolism_Homo sapiens_hsa005911.33376474
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32382256
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27636570
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26982602
43Ether lipid metabolism_Homo sapiens_hsa005651.19885079
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18981205
45Autoimmune thyroid disease_Homo sapiens_hsa053201.17930104
46Fatty acid degradation_Homo sapiens_hsa000711.14523074
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14359604
48Purine metabolism_Homo sapiens_hsa002301.14266021
49Allograft rejection_Homo sapiens_hsa053301.14065254
50mRNA surveillance pathway_Homo sapiens_hsa030151.13006409
51Retinol metabolism_Homo sapiens_hsa008301.10975854
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10809042
53Fatty acid metabolism_Homo sapiens_hsa012121.10680888
54Parkinsons disease_Homo sapiens_hsa050121.09147891
55Tryptophan metabolism_Homo sapiens_hsa003801.03323410
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.02209721
57Morphine addiction_Homo sapiens_hsa050321.00869568
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99689239
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.99624755
60Chemical carcinogenesis_Homo sapiens_hsa052040.99059751
61Inositol phosphate metabolism_Homo sapiens_hsa005620.98873604
62Peroxisome_Homo sapiens_hsa041460.98606481
63Metabolic pathways_Homo sapiens_hsa011000.97003694
64Protein export_Homo sapiens_hsa030600.96925514
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96243296
66Serotonergic synapse_Homo sapiens_hsa047260.95710526
67N-Glycan biosynthesis_Homo sapiens_hsa005100.94485491
68RNA transport_Homo sapiens_hsa030130.94274823
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.93622678
70Caffeine metabolism_Homo sapiens_hsa002320.93475583
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92674296
72Fatty acid elongation_Homo sapiens_hsa000620.91167651
73Glutamatergic synapse_Homo sapiens_hsa047240.90147172
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89952505
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89268577
76Vitamin digestion and absorption_Homo sapiens_hsa049770.89106294
77Regulation of autophagy_Homo sapiens_hsa041400.87707163
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87356289
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87350063
80Hematopoietic cell lineage_Homo sapiens_hsa046400.87125050
81beta-Alanine metabolism_Homo sapiens_hsa004100.85831486
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84950327
83Insulin secretion_Homo sapiens_hsa049110.84602703
84Nitrogen metabolism_Homo sapiens_hsa009100.84399422
85Tyrosine metabolism_Homo sapiens_hsa003500.84225513
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81924478
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81715559
88T cell receptor signaling pathway_Homo sapiens_hsa046600.81635634
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.81514856
90Olfactory transduction_Homo sapiens_hsa047400.80595186
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80093194
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78921541
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78013313
94mTOR signaling pathway_Homo sapiens_hsa041500.76580271
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76383756
96GABAergic synapse_Homo sapiens_hsa047270.75755368
97Acute myeloid leukemia_Homo sapiens_hsa052210.74684359
98Mineral absorption_Homo sapiens_hsa049780.73467070
99B cell receptor signaling pathway_Homo sapiens_hsa046620.73268818
100Type I diabetes mellitus_Homo sapiens_hsa049400.72984380
101Insulin resistance_Homo sapiens_hsa049310.70534376
102Lysosome_Homo sapiens_hsa041420.70347582
103Phenylalanine metabolism_Homo sapiens_hsa003600.68829593
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68525715
105Measles_Homo sapiens_hsa051620.67845449
106Herpes simplex infection_Homo sapiens_hsa051680.66734053
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.63286393
108Propanoate metabolism_Homo sapiens_hsa006400.62541355
109Histidine metabolism_Homo sapiens_hsa003400.62175781
110Glutathione metabolism_Homo sapiens_hsa004800.61956135
111Cell cycle_Homo sapiens_hsa041100.61757771
112Fat digestion and absorption_Homo sapiens_hsa049750.60848588
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59417957
114One carbon pool by folate_Homo sapiens_hsa006700.58376382
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.57615033
116Fructose and mannose metabolism_Homo sapiens_hsa000510.57000960
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56446648
118Sphingolipid metabolism_Homo sapiens_hsa006000.55906584
119Type II diabetes mellitus_Homo sapiens_hsa049300.55141250
120Steroid biosynthesis_Homo sapiens_hsa001000.55018253
121Alzheimers disease_Homo sapiens_hsa050100.54990572
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54965995
123Calcium signaling pathway_Homo sapiens_hsa040200.54384190
124Lysine degradation_Homo sapiens_hsa003100.53620881
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53589744
126Oxidative phosphorylation_Homo sapiens_hsa001900.51875952
127Epstein-Barr virus infection_Homo sapiens_hsa051690.50940776
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50628139
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49115610
130Other glycan degradation_Homo sapiens_hsa005110.49005323
131Arginine and proline metabolism_Homo sapiens_hsa003300.47478844
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47191276
133Choline metabolism in cancer_Homo sapiens_hsa052310.47155822
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46060808
135Circadian rhythm_Homo sapiens_hsa047100.45951585
136Glycerolipid metabolism_Homo sapiens_hsa005610.45687917
137Proteasome_Homo sapiens_hsa030500.44666328
138Fatty acid biosynthesis_Homo sapiens_hsa000610.44500702
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.41324137
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.39774433
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.39142056
142p53 signaling pathway_Homo sapiens_hsa041150.39121389
143Circadian entrainment_Homo sapiens_hsa047130.39105511
144cAMP signaling pathway_Homo sapiens_hsa040240.38982875
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.38833327
146Asthma_Homo sapiens_hsa053100.38342333
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38163629
148Ras signaling pathway_Homo sapiens_hsa040140.37139631
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35899008
150AMPK signaling pathway_Homo sapiens_hsa041520.35254884
151Influenza A_Homo sapiens_hsa051640.35121515
152Amphetamine addiction_Homo sapiens_hsa050310.34915081
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34743423
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34198627
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.33974330
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.33260006
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33187501
158African trypanosomiasis_Homo sapiens_hsa051430.32651605
159NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32120750
160Ovarian steroidogenesis_Homo sapiens_hsa049130.31599888
161Huntingtons disease_Homo sapiens_hsa050160.29556658
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28795541
163Axon guidance_Homo sapiens_hsa043600.28126096
164Cholinergic synapse_Homo sapiens_hsa047250.28020472
165Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27726415

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