RRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.73329048
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06720596
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.82599515
4ribosomal small subunit biogenesis (GO:0042274)4.63028736
5ribosome biogenesis (GO:0042254)4.57835073
6DNA strand elongation involved in DNA replication (GO:0006271)4.51064130
7locomotory exploration behavior (GO:0035641)4.45356936
8pseudouridine synthesis (GO:0001522)4.45351940
9DNA strand elongation (GO:0022616)4.45351187
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44803405
11negative regulation of microtubule polymerization (GO:0031115)4.42041814
12positive regulation of synapse maturation (GO:0090129)4.38830542
13DNA replication initiation (GO:0006270)4.36653956
14regulation of translational termination (GO:0006449)4.24287431
15synaptic vesicle exocytosis (GO:0016079)4.21068184
16maturation of SSU-rRNA (GO:0030490)4.18646608
17folic acid-containing compound biosynthetic process (GO:0009396)4.09418776
18negative regulation of mRNA processing (GO:0050686)4.05725065
19ribonucleoprotein complex biogenesis (GO:0022613)4.04506832
20tRNA methylation (GO:0030488)4.02371082
21glutamate secretion (GO:0014047)3.99908088
22transcription from mitochondrial promoter (GO:0006390)3.97901968
23regulation of synaptic vesicle exocytosis (GO:2000300)3.94761137
24rRNA transcription (GO:0009303)3.91674864
25sodium ion export (GO:0071436)3.90357048
26regulation of mitochondrial translation (GO:0070129)3.88041037
27telomere maintenance via semi-conservative replication (GO:0032201)3.84866641
28DNA replication checkpoint (GO:0000076)3.83157260
29mitochondrial RNA metabolic process (GO:0000959)3.80778860
30mitotic chromosome condensation (GO:0007076)3.80352763
31regulation of synapse structural plasticity (GO:0051823)3.76532386
32peptidyl-arginine omega-N-methylation (GO:0035247)3.72026599
33positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71307172
34layer formation in cerebral cortex (GO:0021819)3.69716909
35viral mRNA export from host cell nucleus (GO:0046784)3.65330633
36negative regulation of mRNA metabolic process (GO:1903312)3.62149838
37mitotic sister chromatid segregation (GO:0000070)3.47970248
38regulation of synaptic vesicle transport (GO:1902803)3.47690842
39ncRNA 3-end processing (GO:0043628)3.47125282
40neurotransmitter secretion (GO:0007269)3.42713846
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41883486
42tRNA modification (GO:0006400)3.41251866
43proline biosynthetic process (GO:0006561)3.40630058
44exploration behavior (GO:0035640)3.38376665
45nucleobase biosynthetic process (GO:0046112)3.37436965
46* rRNA processing (GO:0006364)3.36648369
47regulation of glutamate receptor signaling pathway (GO:1900449)3.34368819
48cellular potassium ion homeostasis (GO:0030007)3.33970728
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32599185
50IMP biosynthetic process (GO:0006188)3.32127042
51peptidyl-arginine N-methylation (GO:0035246)3.30065506
52peptidyl-arginine methylation (GO:0018216)3.30065506
53activation of protein kinase A activity (GO:0034199)3.29495127
54vocalization behavior (GO:0071625)3.29118965
55cerebellar Purkinje cell layer development (GO:0021680)3.28557061
56regulation of neuronal synaptic plasticity (GO:0048168)3.27451270
57folic acid metabolic process (GO:0046655)3.26573698
58protein complex localization (GO:0031503)3.25520329
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24111922
60ribosome assembly (GO:0042255)3.18505484
61* rRNA metabolic process (GO:0016072)3.18496010
62spliceosomal snRNP assembly (GO:0000387)3.17136043
63telomere maintenance via recombination (GO:0000722)3.15394409
64regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14926211
65GDP-mannose metabolic process (GO:0019673)3.14614609
66peptidyl-lysine dimethylation (GO:0018027)3.14226657
67nucleobase-containing small molecule interconversion (GO:0015949)3.13976987
68protein localization to synapse (GO:0035418)3.11682219
69mitotic nuclear envelope disassembly (GO:0007077)3.11148405
70cellular component biogenesis (GO:0044085)3.10992648
71maturation of 5.8S rRNA (GO:0000460)3.10277255
72cell communication by electrical coupling (GO:0010644)3.08907910
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.08124032
74L-serine metabolic process (GO:0006563)3.06242993
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.05185924
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04003949
77DNA replication-dependent nucleosome organization (GO:0034723)3.02020332
78DNA replication-dependent nucleosome assembly (GO:0006335)3.02020332
79IMP metabolic process (GO:0046040)3.01123403
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01070499
81heterochromatin organization (GO:0070828)3.00757145
82response to pheromone (GO:0019236)2.98937007
83histone arginine methylation (GO:0034969)2.98675754
84sister chromatid segregation (GO:0000819)2.97077421
85DNA unwinding involved in DNA replication (GO:0006268)2.96267965
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95982362
87regulation of NFAT protein import into nucleus (GO:0051532)2.95549818
88pteridine-containing compound biosynthetic process (GO:0042559)2.95498402
89neuromuscular process controlling balance (GO:0050885)2.95286378
90chromatin assembly (GO:0031497)2.92579206
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92482992
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92395390
93regulation of translational fidelity (GO:0006450)2.91391807
94DNA duplex unwinding (GO:0032508)2.90746341
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89586786
96neuromuscular process controlling posture (GO:0050884)2.88614693
97mitotic recombination (GO:0006312)2.88059619
98purine nucleobase biosynthetic process (GO:0009113)2.87809081
99rRNA modification (GO:0000154)2.87632007
100pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.87160569
101protein localization to chromosome, centromeric region (GO:0071459)2.86194070
102* ncRNA processing (GO:0034470)2.84989500
103nuclear envelope disassembly (GO:0051081)2.81544151
104membrane disassembly (GO:0030397)2.81544151
105cellular protein complex localization (GO:0034629)2.81463839
106nuclear envelope reassembly (GO:0031468)2.81095551
107mitotic nuclear envelope reassembly (GO:0007084)2.81095551
108proteasome assembly (GO:0043248)2.79435640
109pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.79319945
110negative regulation of cell size (GO:0045792)2.78233657
111mitotic metaphase plate congression (GO:0007080)2.78206512
112positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76848636
113DNA geometric change (GO:0032392)2.75476773
114chromosome condensation (GO:0030261)2.75380727
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.75248746
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74475834
117Golgi transport vesicle coating (GO:0048200)2.74279572
118COPI coating of Golgi vesicle (GO:0048205)2.74279572
119UTP biosynthetic process (GO:0006228)2.73208282
120DNA conformation change (GO:0071103)2.73055126
121nuclear pore complex assembly (GO:0051292)2.72676498
122regulation of translational elongation (GO:0006448)2.72421955
123glycolytic process (GO:0006096)2.71771778
124regulation of defense response to virus by virus (GO:0050690)2.71704103
125tRNA aminoacylation for protein translation (GO:0006418)2.70464471
126base-excision repair (GO:0006284)2.70296271
127protein-DNA complex disassembly (GO:0032986)2.69799427
128nucleosome disassembly (GO:0006337)2.69799427
129pre-miRNA processing (GO:0031054)2.69315055
130mitochondrial DNA metabolic process (GO:0032042)2.69290142
131RNA methylation (GO:0001510)2.69282241
132regulation of synapse maturation (GO:0090128)2.69159208
133histone H2A acetylation (GO:0043968)2.69042916
134RNA modification (GO:0009451)2.68281403
135tRNA aminoacylation (GO:0043039)2.67957141
136amino acid activation (GO:0043038)2.67957141
137termination of RNA polymerase II transcription (GO:0006369)2.67947715
138mRNA splicing, via spliceosome (GO:0000398)2.67717060
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.67717060
140tetrahydrofolate metabolic process (GO:0046653)2.65936228
141iron-sulfur cluster assembly (GO:0016226)2.63417577
142metallo-sulfur cluster assembly (GO:0031163)2.63417577
143pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63020256
144protein targeting to mitochondrion (GO:0006626)2.62075214
145negative regulation of organelle assembly (GO:1902116)2.55389129
146cerebellar Purkinje cell differentiation (GO:0021702)2.55055033
147antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.53174732
148vesicle transport along microtubule (GO:0047496)2.51966501
149negative regulation of RNA splicing (GO:0033119)2.51120814
150regulation of synaptic plasticity (GO:0048167)2.51105692
151long-term memory (GO:0007616)2.50439375
152spliceosomal tri-snRNP complex assembly (GO:0000244)2.50028482
153positive regulation of membrane potential (GO:0045838)2.49460788
154proline transport (GO:0015824)2.48230550
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.48041080
156signal complex assembly (GO:0007172)2.46867654
157mitotic G1 DNA damage checkpoint (GO:0031571)2.46664872
158antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.46622036
159antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.46622036
160positive regulation of neurotransmitter transport (GO:0051590)2.45482634
161dopamine receptor signaling pathway (GO:0007212)2.43993570
162axon cargo transport (GO:0008088)2.42310128
163ionotropic glutamate receptor signaling pathway (GO:0035235)2.42116204
164establishment of nucleus localization (GO:0040023)2.42019105
165mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.40009086
166membrane repolarization (GO:0086009)2.39777638
167positive regulation of neurotransmitter secretion (GO:0001956)2.39367205
168synaptic transmission, glutamatergic (GO:0035249)2.39261471
169glucocorticoid receptor signaling pathway (GO:0042921)2.36581055
170regulation of chromatin binding (GO:0035561)2.36445953
171neurotransmitter transport (GO:0006836)2.35369746
172adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.35317893
173clathrin coat assembly (GO:0048268)2.34641346
174positive regulation of fibroblast migration (GO:0010763)2.33358746
175calcium ion-dependent exocytosis (GO:0017156)2.32280616
176cellular sodium ion homeostasis (GO:0006883)2.32230552
177membrane depolarization during action potential (GO:0086010)2.31114297
178positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.30967883
179regulation of early endosome to late endosome transport (GO:2000641)2.30742872
180prepulse inhibition (GO:0060134)2.30181399
181regulation of ARF protein signal transduction (GO:0032012)2.28658185
182regulation of neurotransmitter levels (GO:0001505)2.27929371
183organelle transport along microtubule (GO:0072384)2.27478098
184formation of translation preinitiation complex (GO:0001731)2.26409194
185postreplication repair (GO:0006301)2.26350391
186membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.26045976
187cell migration in hindbrain (GO:0021535)2.24856895
188regulation of neurotransmitter secretion (GO:0046928)2.24655716
189regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.24478528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79844052
2E2F7_22180533_ChIP-Seq_HELA_Human3.74091930
3MYC_22102868_ChIP-Seq_BL_Human3.12058000
4EZH2_22144423_ChIP-Seq_EOC_Human2.89957273
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73241626
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70744674
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.46522466
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44242237
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.41296700
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.37266106
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.36023335
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.32213604
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28164322
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16680052
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13854552
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12332771
17* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.07858652
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01723242
19XRN2_22483619_ChIP-Seq_HELA_Human1.96475726
20DCP1A_22483619_ChIP-Seq_HELA_Human1.95529236
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94869915
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93206057
23LXR_22292898_ChIP-Seq_THP-1_Human1.90431308
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86139331
25CIITA_25753668_ChIP-Seq_RAJI_Human1.80160439
26KDM2B_26808549_Chip-Seq_DND41_Human1.77657131
27SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.76001541
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.72967943
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72207244
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71572149
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.70415613
32VDR_21846776_ChIP-Seq_THP-1_Human1.70081395
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68791116
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68505132
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68265294
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65817009
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64548137
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63606980
39REST_21632747_ChIP-Seq_MESCs_Mouse1.62874247
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.62174467
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61247763
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.61038852
43* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60154790
44* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.60044744
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58751236
46TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.55806741
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.54143180
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52821015
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52629726
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52364975
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51963111
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50856199
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.50763138
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50176807
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48530907
56* P68_20966046_ChIP-Seq_HELA_Human1.48301748
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48034829
58* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47915725
59TCF7_22412390_ChIP-Seq_EML_Mouse1.47692625
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46363043
61ZNF263_19887448_ChIP-Seq_K562_Human1.45489586
62FOXP3_21729870_ChIP-Seq_TREG_Human1.45365767
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41762597
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38470106
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36389592
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35281571
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34401560
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33968552
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33431035
70* GABP_19822575_ChIP-Seq_HepG2_Human1.32087831
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30455553
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.29988135
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29646493
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29543531
75SMC4_20622854_ChIP-Seq_HELA_Human1.29529912
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29344492
77* FOXP1_21924763_ChIP-Seq_HESCs_Human1.29259359
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29038864
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28921577
80PHF8_20622854_ChIP-Seq_HELA_Human1.28763165
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28325027
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28231492
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.27854593
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27135489
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25744133
86VDR_23849224_ChIP-Seq_CD4+_Human1.25337005
87KDM2B_26808549_Chip-Seq_K562_Human1.25196336
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.24398243
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23737363
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23086735
91TFEB_21752829_ChIP-Seq_HELA_Human1.23044829
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22958053
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21640284
94BCL6_27268052_Chip-Seq_Bcells_Human1.21473815
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21456498
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.20287633
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20007730
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.18415418
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.17883297
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17293790
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17209373
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17086785
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17024660
104KDM5A_27292631_Chip-Seq_BREAST_Human1.16124361
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16002776
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15372266
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14102597
108TTF2_22483619_ChIP-Seq_HELA_Human1.13886321
109* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13302646
110DROSHA_22980978_ChIP-Seq_HELA_Human1.12897773
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11621574
112* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10963848
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10198442
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.09807230
115MAF_26560356_Chip-Seq_TH2_Human1.09483899
116BCOR_27268052_Chip-Seq_Bcells_Human1.09238812
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08541588
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07344806
119CREB1_26743006_Chip-Seq_LNCaP_Human1.07341383
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06490454
121MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05638625
122UTX_26944678_Chip-Seq_JUKART_Human1.05578393
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05407968
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03379227
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02550486
126* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01941954
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01795370
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01514216
129ZNF274_21170338_ChIP-Seq_K562_Hela1.01408395
130ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01372132
131NCOR1_26117541_ChIP-Seq_K562_Human1.00684266
132* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00621191
133TP53_22127205_ChIP-Seq_IMR90_Human1.00302897
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.00277238
135* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00147837
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99737142
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99681550
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98795742
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98593436
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98113978
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97879612
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97753806
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97191471
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97059878
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.96814393
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96690760
147* CTCF_26484167_Chip-Seq_Bcells_Mouse0.96314404
148RACK7_27058665_Chip-Seq_MCF-7_Human0.95976708
149AR_21909140_ChIP-Seq_LNCAP_Human0.95691339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97098042
2MP0003635_abnormal_synaptic_transmissio3.30788357
3MP0008058_abnormal_DNA_repair3.15978473
4MP0003806_abnormal_nucleotide_metabolis2.73088666
5MP0005058_abnormal_lysosome_morphology2.56337626
6MP0008932_abnormal_embryonic_tissue2.55157299
7MP0005451_abnormal_body_composition2.54521729
8MP0002877_abnormal_melanocyte_morpholog2.49748480
9MP0003123_paternal_imprinting2.49667349
10MP0002063_abnormal_learning/memory/cond2.48513215
11MP0003880_abnormal_central_pattern2.45932098
12MP0002909_abnormal_adrenal_gland2.44954957
13MP0003786_premature_aging2.38585082
14MP0009333_abnormal_splenocyte_physiolog2.31755193
15MP0004270_analgesia2.30710491
16MP0008877_abnormal_DNA_methylation2.24160705
17MP0008057_abnormal_DNA_replication2.22529165
18MP0001968_abnormal_touch/_nociception2.17303585
19MP0009745_abnormal_behavioral_response2.17294274
20MP0003122_maternal_imprinting2.14956555
21MP0002064_seizures2.11304318
22MP0005410_abnormal_fertilization2.09356164
23MP0002653_abnormal_ependyma_morphology2.08433407
24MP0009278_abnormal_bone_marrow2.08132121
25MP0002822_catalepsy2.08001181
26MP0009046_muscle_twitch2.07722240
27MP0004811_abnormal_neuron_physiology2.07139169
28MP0005423_abnormal_somatic_nervous2.05972981
29MP0004233_abnormal_muscle_weight2.05454477
30MP0004858_abnormal_nervous_system2.02021982
31MP0004185_abnormal_adipocyte_glucose1.95882217
32MP0000678_abnormal_parathyroid_gland1.90605799
33MP0003283_abnormal_digestive_organ1.87435566
34MP0002736_abnormal_nociception_after1.81617284
35MP0002572_abnormal_emotion/affect_behav1.77792329
36MP0008961_abnormal_basal_metabolism1.77781107
37MP0003329_amyloid_beta_deposits1.72246631
38MP0008569_lethality_at_weaning1.72242534
39MP0009840_abnormal_foam_cell1.72098749
40MP0003787_abnormal_imprinting1.63895322
41MP0002272_abnormal_nervous_system1.59077610
42MP0003111_abnormal_nucleus_morphology1.58434686
43MP0002734_abnormal_mechanical_nocicepti1.57684388
44MP0005501_abnormal_skin_physiology1.54204101
45MP0006035_abnormal_mitochondrial_morpho1.53390242
46MP0000751_myopathy1.46588662
47MP0002184_abnormal_innervation1.45735137
48MP0002733_abnormal_thermal_nociception1.44808407
49MP0003693_abnormal_embryo_hatching1.44326627
50MP0001730_embryonic_growth_arrest1.41539746
51MP0004957_abnormal_blastocyst_morpholog1.41485981
52MP0002254_reproductive_system_inflammat1.37438190
53MP0001672_abnormal_embryogenesis/_devel1.37013717
54MP0005380_embryogenesis_phenotype1.37013717
55MP0000955_abnormal_spinal_cord1.36726561
56MP0002735_abnormal_chemical_nociception1.36303717
57MP0003121_genomic_imprinting1.35337627
58MP0002089_abnormal_postnatal_growth/wei1.32602549
59MP0010094_abnormal_chromosome_stability1.31842626
60MP0003453_abnormal_keratinocyte_physiol1.31213021
61MP0000013_abnormal_adipose_tissue1.31209621
62MP0003879_abnormal_hair_cell1.30898020
63MP0000003_abnormal_adipose_tissue1.30017318
64MP0003077_abnormal_cell_cycle1.29008910
65MP0000490_abnormal_crypts_of1.27285343
66MP0006036_abnormal_mitochondrial_physio1.26721151
67MP0001970_abnormal_pain_threshold1.25214559
68MP0002019_abnormal_tumor_incidence1.25211809
69MP0002557_abnormal_social/conspecific_i1.21473900
70MP0001873_stomach_inflammation1.20333534
71MP0003984_embryonic_growth_retardation1.19601838
72MP0001853_heart_inflammation1.18389884
73MP0001661_extended_life_span1.18144851
74MP0003186_abnormal_redox_activity1.15272052
75MP0008007_abnormal_cellular_replicative1.15053590
76MP0001849_ear_inflammation1.13202950
77MP0002067_abnormal_sensory_capabilities1.11915932
78MP0002088_abnormal_embryonic_growth/wei1.11812637
79MP0003698_abnormal_male_reproductive1.11783148
80MP0010352_gastrointestinal_tract_polyps1.10356613
81MP0002234_abnormal_pharynx_morphology1.10180203
82MP0001727_abnormal_embryo_implantation1.09279811
83MP0005623_abnormal_meninges_morphology1.08645490
84MP0002152_abnormal_brain_morphology1.08321059
85MP0003315_abnormal_perineum_morphology1.08274932
86MP0002249_abnormal_larynx_morphology1.08139420
87MP0001501_abnormal_sleep_pattern1.08105450
88MP0000537_abnormal_urethra_morphology1.07721594
89MP0002796_impaired_skin_barrier1.06447544
90MP0002882_abnormal_neuron_morphology1.04567081
91MP0001440_abnormal_grooming_behavior1.03033097
92MP0000534_abnormal_ureter_morphology1.00740953
93MP0000681_abnormal_thyroid_gland1.00471502
94MP0005386_behavior/neurological_phenoty0.99857205
95MP0004924_abnormal_behavior0.99857205
96MP0000358_abnormal_cell_content/0.98948759
97MP0002066_abnormal_motor_capabilities/c0.98599901
98MP0004808_abnormal_hematopoietic_stem0.97761137
99MP0010030_abnormal_orbit_morphology0.97740168
100MP0002080_prenatal_lethality0.97545402
101MP0003172_abnormal_lysosome_physiology0.97290526
102MP0001486_abnormal_startle_reflex0.96848582
103MP0003763_abnormal_thymus_physiology0.95988506
104MP0009780_abnormal_chondrocyte_physiolo0.94915600
105MP0000350_abnormal_cell_proliferation0.94869996
106MP0005076_abnormal_cell_differentiation0.92902694
107MP0001545_abnormal_hematopoietic_system0.91837591
108MP0005397_hematopoietic_system_phenotyp0.91837591
109MP0001881_abnormal_mammary_gland0.91716296
110MP0002084_abnormal_developmental_patter0.90305552
111MP0003861_abnormal_nervous_system0.90102214
112MP0003119_abnormal_digestive_system0.89239458
113MP0008995_early_reproductive_senescence0.89237729
114MP0009672_abnormal_birth_weight0.89116715
115MP0008770_decreased_survivor_rate0.88701950
116MP0001216_abnormal_epidermal_layer0.88654945
117MP0008260_abnormal_autophagy0.87576733
118MP0001697_abnormal_embryo_size0.87139417
119MP0000858_altered_metastatic_potential0.85939589
120MP0001348_abnormal_lacrimal_gland0.85892063
121MP0002398_abnormal_bone_marrow0.85770958
122MP0005310_abnormal_salivary_gland0.84114083
123MP0008872_abnormal_physiological_respon0.83946376
124MP0002429_abnormal_blood_cell0.83762445
125MP0001346_abnormal_lacrimal_gland0.83675735
126MP0002269_muscular_atrophy0.82917103
127MP0002722_abnormal_immune_system0.82908760
128MP0005384_cellular_phenotype0.82374259
129MP0000569_abnormal_digit_pigmentation0.82369619
130MP0003718_maternal_effect0.81875183
131MP0010234_abnormal_vibrissa_follicle0.81809485
132MP0002086_abnormal_extraembryonic_tissu0.81270894
133MP0002148_abnormal_hypersensitivity_rea0.81263894
134MP0001929_abnormal_gametogenesis0.80106782
135MP0005375_adipose_tissue_phenotype0.80034251
136MP0005621_abnormal_cell_physiology0.78955210
137MP0001764_abnormal_homeostasis0.78663823
138MP0002396_abnormal_hematopoietic_system0.77834699
139MP0004947_skin_inflammation0.77699956
140MP0004885_abnormal_endolymph0.76247219
141MP0000747_muscle_weakness0.75618590
142MP0003633_abnormal_nervous_system0.75600573
143MP0005499_abnormal_olfactory_system0.75578208
144MP0005394_taste/olfaction_phenotype0.75578208
145MP0010307_abnormal_tumor_latency0.75043032
146MP0002098_abnormal_vibrissa_morphology0.73484129
147MP0001529_abnormal_vocalization0.73467131
148MP0005187_abnormal_penis_morphology0.72812869
149MP0002161_abnormal_fertility/fecundity0.72671502
150MP0001984_abnormal_olfaction0.72082694
151MP0000750_abnormal_muscle_regeneration0.71398752
152MP0004133_heterotaxia0.71339781
153MP0003115_abnormal_respiratory_system0.70772120
154MP0009931_abnormal_skin_appearance0.70421141
155MP0002970_abnormal_white_adipose0.70324845
156MP0003075_altered_response_to0.70002667
157MP0005670_abnormal_white_adipose0.68820410
158MP0000313_abnormal_cell_death0.68749250
159MP0000703_abnormal_thymus_morphology0.67471589
160MP0002111_abnormal_tail_morphology0.67185848
161MP0002069_abnormal_eating/drinking_beha0.67139594
162MP0002085_abnormal_embryonic_tissue0.67101354
163MP0003705_abnormal_hypodermis_morpholog0.67044346
164MP0001919_abnormal_reproductive_system0.66679228
165MP0000689_abnormal_spleen_morphology0.66297081
166MP0002210_abnormal_sex_determination0.66011428
167MP0003221_abnormal_cardiomyocyte_apopto0.65861781
168MP0004197_abnormal_fetal_growth/weight/0.64803965
169MP0000733_abnormal_muscle_development0.63766433
170MP0002163_abnormal_gland_morphology0.63653545
171MP0005083_abnormal_biliary_tract0.62254644
172MP0000716_abnormal_immune_system0.61140206
173MP0006292_abnormal_olfactory_placode0.60847359

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.76812072
2Myokymia (HP:0002411)4.64615619
3Microvesicular hepatic steatosis (HP:0001414)4.33913140
4Progressive muscle weakness (HP:0003323)4.31954484
5Aplasia/Hypoplasia of the sacrum (HP:0008517)4.03409878
6Ragged-red muscle fibers (HP:0003200)3.92469518
7Hyperacusis (HP:0010780)3.87238328
8Visual hallucinations (HP:0002367)3.80798200
9Insomnia (HP:0100785)3.71367319
10Multiple enchondromatosis (HP:0005701)3.66633572
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49909019
12Squamous cell carcinoma (HP:0002860)3.44190615
13Pointed chin (HP:0000307)3.39946563
14Amyotrophic lateral sclerosis (HP:0007354)3.38205196
15Annular pancreas (HP:0001734)3.19559343
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.16567518
17Microretrognathia (HP:0000308)3.16558355
18Birth length less than 3rd percentile (HP:0003561)3.15446832
19Chromsome breakage (HP:0040012)3.09879369
20Abnormal number of erythroid precursors (HP:0012131)3.05521280
21Increased cerebral lipofuscin (HP:0011813)2.97183654
22Ankle clonus (HP:0011448)2.94546853
23Abnormality of cells of the erythroid lineage (HP:0012130)2.90416559
24Focal seizures (HP:0007359)2.87013256
25Elfin facies (HP:0004428)2.85952670
26Depression (HP:0000716)2.85563536
27Renal duplication (HP:0000075)2.83907450
28Septate vagina (HP:0001153)2.80513601
29Focal motor seizures (HP:0011153)2.77661424
30Reticulocytopenia (HP:0001896)2.77544856
31Upper limb amyotrophy (HP:0009129)2.76674524
32Distal upper limb amyotrophy (HP:0007149)2.76674524
33Hand muscle atrophy (HP:0009130)2.76601663
34Impaired vibration sensation in the lower limbs (HP:0002166)2.73458631
35Trismus (HP:0000211)2.70319839
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68359315
37Atrophy/Degeneration involving motor neurons (HP:0007373)2.67456081
38Neoplasm of the heart (HP:0100544)2.66660235
39Abnormality of glycolysis (HP:0004366)2.61050785
40Impaired smooth pursuit (HP:0007772)2.56573904
41Progressive external ophthalmoplegia (HP:0000590)2.56134617
42Ependymoma (HP:0002888)2.54502603
43Urinary urgency (HP:0000012)2.52596139
44Hypercortisolism (HP:0001578)2.52495785
45Overriding aorta (HP:0002623)2.51177183
46Hypergonadotropic hypogonadism (HP:0000815)2.47324785
47Dysmetric saccades (HP:0000641)2.46947338
48Papilledema (HP:0001085)2.45602960
49Poor eye contact (HP:0000817)2.44941980
50Renovascular hypertension (HP:0100817)2.42778104
51Shoulder girdle muscle weakness (HP:0003547)2.42295962
52Cutaneous melanoma (HP:0012056)2.41732764
53Ventricular fibrillation (HP:0001663)2.41133783
54Resting tremor (HP:0002322)2.40654928
55Rough bone trabeculation (HP:0100670)2.40114201
56Breast hypoplasia (HP:0003187)2.39030450
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38895408
58Bowel diverticulosis (HP:0005222)2.38486231
59Abnormality of ocular smooth pursuit (HP:0000617)2.38155234
60Cleft eyelid (HP:0000625)2.35099899
61Increased serum lactate (HP:0002151)2.34339048
62Achilles tendon contracture (HP:0001771)2.34264935
63Large eyes (HP:0001090)2.31903029
64Hypertensive crisis (HP:0100735)2.30998554
65Abnormality of liposaccharide metabolism (HP:0010968)2.26149585
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.26149585
67Abnormality of glycolipid metabolism (HP:0010969)2.26149585
68Testicular atrophy (HP:0000029)2.26026132
69Abnormality of the anterior horn cell (HP:0006802)2.25881888
70Degeneration of anterior horn cells (HP:0002398)2.25881888
71Supranuclear gaze palsy (HP:0000605)2.23266806
72Action tremor (HP:0002345)2.23129360
73Epileptic encephalopathy (HP:0200134)2.22883236
74Increased serum pyruvate (HP:0003542)2.21309687
75Increased serum ferritin (HP:0003281)2.19637194
76Premature ovarian failure (HP:0008209)2.19470369
77Increased nuchal translucency (HP:0010880)2.18736350
78Abnormality of the astrocytes (HP:0100707)2.18525545
79Astrocytoma (HP:0009592)2.18525545
80Pelvic girdle muscle weakness (HP:0003749)2.18448168
81Abnormal social behavior (HP:0012433)2.18019250
82Impaired social interactions (HP:0000735)2.18019250
83Abnormality of the preputium (HP:0100587)2.17953617
84Ulnar bowing (HP:0003031)2.15892367
85Aplasia/Hypoplasia of the patella (HP:0006498)2.15289539
86Horseshoe kidney (HP:0000085)2.14914183
87Abnormality of the umbilical cord (HP:0010881)2.14888529
88Deep palmar crease (HP:0006191)2.13484150
89Type I transferrin isoform profile (HP:0003642)2.13444798
90Diminished motivation (HP:0000745)2.12252427
91Abnormality of cochlea (HP:0000375)2.11365743
92Apathy (HP:0000741)2.10588303
93Intellectual disability, profound (HP:0002187)2.08342946
94Abnormality of the motor neurons (HP:0002450)2.07801380
95Abnormal neuron morphology (HP:0012757)2.07801380
96Truncal ataxia (HP:0002078)2.07678582
97Ankyloglossia (HP:0010296)2.06870227
98Abnormal gallbladder physiology (HP:0012438)2.03052999
99Cholecystitis (HP:0001082)2.03052999
100Spinal canal stenosis (HP:0003416)2.01553292
101Patellar aplasia (HP:0006443)2.01531070
102Entropion (HP:0000621)2.00586401
103Abnormality of the fetal cardiovascular system (HP:0010948)1.99462877
104Abnormal umbilical cord blood vessels (HP:0011403)1.99462877
105Single umbilical artery (HP:0001195)1.99462877
106Urethral obstruction (HP:0000796)1.98587259
107Reduced antithrombin III activity (HP:0001976)1.98093707
108Bundle branch block (HP:0011710)1.97926705
109Progressive cerebellar ataxia (HP:0002073)1.97433597
110Abnormality of reticulocytes (HP:0004312)1.97229430
111Anxiety (HP:0000739)1.97183001
112Neoplasm of the peripheral nervous system (HP:0100007)1.97097716
113Flat cornea (HP:0007720)1.94858697
114Abnormal trabecular bone morphology (HP:0100671)1.93528749
115Ureteral duplication (HP:0000073)1.93339167
116Angiofibromas (HP:0010615)1.93214725
117Adenoma sebaceum (HP:0009720)1.93214725
118Abnormality of the musculature of the pelvis (HP:0001469)1.93164647
119Abnormality of the hip-girdle musculature (HP:0001445)1.93164647
120Hyperthyroidism (HP:0000836)1.93025669
121Postural instability (HP:0002172)1.92903776
122Cerebral hypomyelination (HP:0006808)1.92880992
123Increased intramyocellular lipid droplets (HP:0012240)1.92810671
124Bradykinesia (HP:0002067)1.91267726
125Unsteady gait (HP:0002317)1.90751434
126Abnormality of the carotid arteries (HP:0005344)1.90474311
127Hemiplegia (HP:0002301)1.90352695
128Unilateral renal agenesis (HP:0000122)1.89710776
129Abnormality of the Achilles tendon (HP:0005109)1.89388233
130Absence seizures (HP:0002121)1.89294138
131Urinary bladder sphincter dysfunction (HP:0002839)1.88612583
132Short thumb (HP:0009778)1.88594246
133Increased muscle lipid content (HP:0009058)1.86921971
134Atonic seizures (HP:0010819)1.86573950
135Cerebral aneurysm (HP:0004944)1.86550027
136Abnormality of oral frenula (HP:0000190)1.85252143
137Abnormal number of incisors (HP:0011064)1.83918706
138Megalencephaly (HP:0001355)1.83825274
139Delusions (HP:0000746)1.83157470
140Abnormal eating behavior (HP:0100738)1.82992744
141Torticollis (HP:0000473)1.82645542
142Dysautonomia (HP:0002459)1.82503058
143Patellar dislocation (HP:0002999)1.81789860
144Aplastic anemia (HP:0001915)1.81716700
145Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81545167
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81134161
147Pancytopenia (HP:0001876)1.81008223
148Menstrual irregularities (HP:0000858)1.80543678
149Focal dystonia (HP:0004373)1.80539018
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80297741
151Abnormal protein N-linked glycosylation (HP:0012347)1.80297741
152Abnormal protein glycosylation (HP:0012346)1.80297741
153Abnormal glycosylation (HP:0012345)1.80297741
154Mutism (HP:0002300)1.80245895
155Spastic gait (HP:0002064)1.80220578
156Vaginal fistula (HP:0004320)1.79505796
157Broad distal phalanx of finger (HP:0009836)1.79422785
158Limb-girdle muscle atrophy (HP:0003797)1.79168417
159Absent thumb (HP:0009777)1.79163670
160Proximal placement of thumb (HP:0009623)1.78471212
161Sacral dimple (HP:0000960)1.78153351
162Poikiloderma (HP:0001029)1.77762208
163Hypoventilation (HP:0002791)1.76886672
164Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75970163
165Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75970163
166Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75688650
167Clonus (HP:0002169)1.75057969
168Lactic acidosis (HP:0003128)1.74358021
169Truncus arteriosus (HP:0001660)1.74197002
170Abnormal mitochondria in muscle tissue (HP:0008316)1.73497798
171Abnormality of DNA repair (HP:0003254)1.73133622
172Pseudobulbar signs (HP:0002200)1.73026546
173Selective tooth agenesis (HP:0001592)1.72558273
174Basal cell carcinoma (HP:0002671)1.72436968
175Progressive microcephaly (HP:0000253)1.71969083
176Centrally nucleated skeletal muscle fibers (HP:0003687)1.71714977
177Absent radius (HP:0003974)1.71195750
178Striae distensae (HP:0001065)1.70959896
179Nonimmune hydrops fetalis (HP:0001790)1.69845381
180Increased CSF lactate (HP:0002490)1.68383444
181Abnormality of the columella (HP:0009929)1.68156224
182Nasal polyposis (HP:0100582)1.68110723
183Aplasia/Hypoplasia of the thymus (HP:0010515)1.67710375
184Megalocornea (HP:0000485)1.67555191
185Primitive neuroectodermal tumor (HP:0030065)1.67360178
186Neuroblastic tumors (HP:0004376)1.67360178
187Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67360178
188Neuroblastoma (HP:0003006)1.67360178
189Enlarged penis (HP:0000040)1.67266146
190Deviation of the thumb (HP:0009603)1.67174311
191Opisthotonus (HP:0002179)1.67157751
192Abnormality of subcutaneous fat tissue (HP:0001001)1.66379150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.49248187
2SMG14.29417026
3IRAK34.17533967
4TRIB33.05083880
5MAP3K93.04159279
6VRK22.89834826
7PRKD32.85318320
8NEK12.71717330
9NTRK32.70640587
10EEF2K2.61756154
11SCYL22.51372947
12TESK12.47946295
13MINK12.42636419
14PKN22.19577111
15TESK22.11180245
16PDK32.09239383
17PDK42.09239383
18PIM22.05523391
19CDK122.01970971
20CAMKK12.01913716
21KSR22.01394179
22SRPK11.91529193
23TSSK61.90849013
24EPHA41.84418315
25DAPK11.84157044
26PAK61.80905608
27TLK11.75918252
28MARK11.75601744
29TAOK11.73536561
30DAPK21.68535502
31BUB11.60469548
32MAP3K41.56960650
33ALK1.51707499
34BRSK11.48832496
35CHEK21.48264126
36CDK191.47252426
37BCKDK1.47159853
38MAP3K101.45901545
39CDC71.45130945
40TTK1.41719334
41PASK1.37197298
42SIK21.34764031
43TAF11.31227858
44CDK71.28581546
45NTRK21.26870167
46KSR11.23777270
47NEK21.21536338
48ZAK1.15741477
49MAP2K31.14851901
50PBK1.14445012
51ICK1.12822089
52UHMK11.12101122
53CCNB11.12013274
54CDK41.11136289
55CAMK1D1.11040097
56ERN11.08681164
57PRPF4B1.08435464
58ARAF1.08253975
59RAF11.07699169
60MAPK111.06295465
61STK381.04219725
62TYRO31.03264907
63RIPK11.02356606
64AURKB1.02287571
65ABL21.02028427
66CDK181.00048544
67CDK151.00010541
68MAP3K110.99829512
69LMTK20.99159104
70PAK40.97013492
71CDK140.96582311
72CDK11A0.96161633
73CAMKK20.94414126
74CDK50.93352784
75LATS20.93011806
76VRK10.91592001
77SIK10.90093577
78NME10.88846778
79NTRK10.85819735
80MAP3K120.85442442
81PRKCG0.83206734
82IKBKB0.82445981
83WEE10.82164444
84STK160.82137258
85LRRK20.81650664
86CDK80.79401593
87PDK20.77257563
88IRAK20.77203340
89LIMK10.74005781
90PRKCI0.73452918
91PRKCH0.73353821
92PTK2B0.72932139
93RET0.71369810
94PNCK0.71084548
95TBK10.66276396
96STK40.64580619
97MAP2K40.63246245
98MAPKAPK50.63018085
99EIF2AK10.62995010
100MAP3K30.62669875
101RPS6KA50.62157428
102CSNK1G30.61719393
103ILK0.61238772
104CDK90.61043359
105CAMK10.60640449
106PDGFRA0.59673313
107DAPK30.59634543
108AKT20.59157708
109RPS6KA40.59138875
110EPHA20.58985005
111FGFR10.58305329
112FES0.55898829
113PDK10.55175968
114CDK10.54188961
115BMX0.53334084
116MARK20.53286323
117MAP3K140.52795439
118STK100.52769802
119MAP2K70.51560405
120MAP2K20.48918923
121PIM10.48916620
122CHEK10.48455325
123MAP3K10.48091863
124AURKA0.47620776
125BRAF0.47318990
126MAPKAPK30.47142976
127PAK10.47012384
128RIPK40.45842524
129RPS6KB20.45783780
130MAP4K10.45729089
131CAMK1G0.45707939
132CSNK1A1L0.44881809
133ATM0.44441600
134PLK40.43932757
135PAK20.43669339
136MAP3K80.41858521
137IRAK40.41774889
138ZAP700.41708989
139CSNK2A10.41590722
140CDK20.40903424
141CSNK2A20.40562564
142TAOK20.40190672
143SIK30.39278572
144RPS6KA10.38780143
145KDR0.38423286
146ATR0.38094868
147MAP3K20.37421590
148CHUK0.36194287
149MTOR0.35609103
150CSNK1E0.35019988
151PLK30.34873081
152EIF2AK20.34315947
153PDPK10.34267395
154PLK10.33971629
155MUSK0.33967942
156PAK30.33792261
157CDC42BPA0.33606106
158RPS6KA20.32689070

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.52099012
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96029500
3One carbon pool by folate_Homo sapiens_hsa006702.62610285
4Ribosome_Homo sapiens_hsa030102.58220769
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44968281
6RNA polymerase_Homo sapiens_hsa030202.44878017
7Pyrimidine metabolism_Homo sapiens_hsa002402.40311010
8Homologous recombination_Homo sapiens_hsa034402.36905499
9Long-term potentiation_Homo sapiens_hsa047202.09799525
10Olfactory transduction_Homo sapiens_hsa047402.02065731
11Nicotine addiction_Homo sapiens_hsa050331.83951048
12Circadian entrainment_Homo sapiens_hsa047131.81694763
13Amphetamine addiction_Homo sapiens_hsa050311.78247437
14Oocyte meiosis_Homo sapiens_hsa041141.77645352
15Non-homologous end-joining_Homo sapiens_hsa034501.70628090
16Fanconi anemia pathway_Homo sapiens_hsa034601.67543488
17Selenocompound metabolism_Homo sapiens_hsa004501.65680758
18DNA replication_Homo sapiens_hsa030301.62573518
19Dopaminergic synapse_Homo sapiens_hsa047281.62276873
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60397450
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59417737
22GABAergic synapse_Homo sapiens_hsa047271.52786561
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49870477
24Insulin secretion_Homo sapiens_hsa049111.49175492
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.48211626
26Spliceosome_Homo sapiens_hsa030401.44467930
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.43696848
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43329056
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42436470
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38580991
31Morphine addiction_Homo sapiens_hsa050321.38492188
32Vitamin B6 metabolism_Homo sapiens_hsa007501.35316505
33RNA transport_Homo sapiens_hsa030131.34396796
34Glioma_Homo sapiens_hsa052141.33457570
35Gastric acid secretion_Homo sapiens_hsa049711.33403846
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32504086
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.32109487
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31380131
39Glutamatergic synapse_Homo sapiens_hsa047241.29780309
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29300724
41Oxytocin signaling pathway_Homo sapiens_hsa049211.28569737
42Cholinergic synapse_Homo sapiens_hsa047251.27322235
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26770382
44Salivary secretion_Homo sapiens_hsa049701.26148726
45Other glycan degradation_Homo sapiens_hsa005111.25879517
46Estrogen signaling pathway_Homo sapiens_hsa049151.25011104
47Folate biosynthesis_Homo sapiens_hsa007901.23955541
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.18766504
49Gap junction_Homo sapiens_hsa045401.17493549
50mTOR signaling pathway_Homo sapiens_hsa041501.12124035
51Systemic lupus erythematosus_Homo sapiens_hsa053221.10912013
52mRNA surveillance pathway_Homo sapiens_hsa030151.10711728
53VEGF signaling pathway_Homo sapiens_hsa043701.10570483
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08218480
55Purine metabolism_Homo sapiens_hsa002301.07351470
56Mismatch repair_Homo sapiens_hsa034301.06812668
57Cocaine addiction_Homo sapiens_hsa050301.05350761
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03937252
59Non-small cell lung cancer_Homo sapiens_hsa052231.02596757
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02564254
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01025649
62Galactose metabolism_Homo sapiens_hsa000521.00404642
63Colorectal cancer_Homo sapiens_hsa052100.99858268
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99706628
65GnRH signaling pathway_Homo sapiens_hsa049120.97963403
66Endometrial cancer_Homo sapiens_hsa052130.97321971
67Viral carcinogenesis_Homo sapiens_hsa052030.96194693
68Biosynthesis of amino acids_Homo sapiens_hsa012300.94651163
69Type II diabetes mellitus_Homo sapiens_hsa049300.94205004
70Glucagon signaling pathway_Homo sapiens_hsa049220.93444009
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91387801
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91349849
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90931620
74Renin secretion_Homo sapiens_hsa049240.90923946
75Thyroid cancer_Homo sapiens_hsa052160.89705707
76Chronic myeloid leukemia_Homo sapiens_hsa052200.88272447
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88229631
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87370335
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85674413
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85574222
81Calcium signaling pathway_Homo sapiens_hsa040200.85487841
82HIF-1 signaling pathway_Homo sapiens_hsa040660.85044735
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83760982
84ErbB signaling pathway_Homo sapiens_hsa040120.82192063
85Basal transcription factors_Homo sapiens_hsa030220.81498195
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81314893
87Herpes simplex infection_Homo sapiens_hsa051680.81211339
88Endocytosis_Homo sapiens_hsa041440.79626969
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.79496915
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79374486
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79060495
92Apoptosis_Homo sapiens_hsa042100.78929921
93Cell cycle_Homo sapiens_hsa041100.77941864
94Long-term depression_Homo sapiens_hsa047300.77881857
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77732967
96Alcoholism_Homo sapiens_hsa050340.77108232
97Base excision repair_Homo sapiens_hsa034100.77092240
98Lysine degradation_Homo sapiens_hsa003100.76972424
99Lysosome_Homo sapiens_hsa041420.76965075
100p53 signaling pathway_Homo sapiens_hsa041150.75740363
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75063243
102RNA degradation_Homo sapiens_hsa030180.73948448
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72964519
104Melanogenesis_Homo sapiens_hsa049160.72893266
105Vibrio cholerae infection_Homo sapiens_hsa051100.72633085
106Insulin signaling pathway_Homo sapiens_hsa049100.71450493
107Proteasome_Homo sapiens_hsa030500.70932115
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70100657
109Taste transduction_Homo sapiens_hsa047420.70037798
110cAMP signaling pathway_Homo sapiens_hsa040240.69743981
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67459737
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67459245
113Collecting duct acid secretion_Homo sapiens_hsa049660.65849848
114Cardiac muscle contraction_Homo sapiens_hsa042600.64631856
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64290813
116Pyruvate metabolism_Homo sapiens_hsa006200.64273146
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62691666
118Bladder cancer_Homo sapiens_hsa052190.60988827
119Huntingtons disease_Homo sapiens_hsa050160.59874566
120Sulfur metabolism_Homo sapiens_hsa009200.59021648
121Fructose and mannose metabolism_Homo sapiens_hsa000510.57849974
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.57688981
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56476898
124Oxidative phosphorylation_Homo sapiens_hsa001900.55619247
125HTLV-I infection_Homo sapiens_hsa051660.55524380
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55448679
127Shigellosis_Homo sapiens_hsa051310.54763777
128Acute myeloid leukemia_Homo sapiens_hsa052210.54747688
129Carbon metabolism_Homo sapiens_hsa012000.53678398
130Thyroid hormone synthesis_Homo sapiens_hsa049180.53660189
131N-Glycan biosynthesis_Homo sapiens_hsa005100.53305641
132Parkinsons disease_Homo sapiens_hsa050120.53160497
133MAPK signaling pathway_Homo sapiens_hsa040100.52929590
134Pentose phosphate pathway_Homo sapiens_hsa000300.52785576
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52041615
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51181147
137Rap1 signaling pathway_Homo sapiens_hsa040150.50192393
138T cell receptor signaling pathway_Homo sapiens_hsa046600.49451161
139Dorso-ventral axis formation_Homo sapiens_hsa043200.47395468
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47243719
141Epstein-Barr virus infection_Homo sapiens_hsa051690.46771827
142Glutathione metabolism_Homo sapiens_hsa004800.46725760
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46649485
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46643635
145Dilated cardiomyopathy_Homo sapiens_hsa054140.46550974
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46038123
147Nucleotide excision repair_Homo sapiens_hsa034200.45929906
148Primary immunodeficiency_Homo sapiens_hsa053400.44030617
149Hepatitis B_Homo sapiens_hsa051610.41286423
150Metabolic pathways_Homo sapiens_hsa011000.39084185
151Fatty acid elongation_Homo sapiens_hsa000620.38236193
152Pancreatic cancer_Homo sapiens_hsa052120.37170058
153Notch signaling pathway_Homo sapiens_hsa043300.36577358
154TNF signaling pathway_Homo sapiens_hsa046680.36452275
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.34154693
156MicroRNAs in cancer_Homo sapiens_hsa052060.33140816
157Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32814244
158Prion diseases_Homo sapiens_hsa050200.32424260
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.31472505
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30273199
161B cell receptor signaling pathway_Homo sapiens_hsa046620.29585436
162Arginine and proline metabolism_Homo sapiens_hsa003300.29418352
163Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28988616
164Salmonella infection_Homo sapiens_hsa051320.26737800
165Hepatitis C_Homo sapiens_hsa051600.26696608

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