RRP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.03203408
2nuclear pore complex assembly (GO:0051292)6.01174525
3IMP biosynthetic process (GO:0006188)5.00161856
4ribosomal small subunit biogenesis (GO:0042274)4.97123073
5folic acid-containing compound biosynthetic process (GO:0009396)4.87488216
6mitotic nuclear envelope disassembly (GO:0007077)4.87001658
7DNA unwinding involved in DNA replication (GO:0006268)4.85779399
8nucleobase biosynthetic process (GO:0046112)4.83805312
9membrane disassembly (GO:0030397)4.58172266
10nuclear envelope disassembly (GO:0051081)4.58172266
11protein localization to kinetochore (GO:0034501)4.54634987
12regulation of translational termination (GO:0006449)4.49559501
13pore complex assembly (GO:0046931)4.48433785
14DNA replication initiation (GO:0006270)4.36244293
15pre-miRNA processing (GO:0031054)4.35415120
16ribosome biogenesis (GO:0042254)4.34952825
17IMP metabolic process (GO:0046040)4.34063797
18DNA replication-dependent nucleosome assembly (GO:0006335)4.29134217
19DNA replication-dependent nucleosome organization (GO:0034723)4.29134217
20formation of translation preinitiation complex (GO:0001731)4.23482993
21regulation of translational fidelity (GO:0006450)4.17288445
22ribosome assembly (GO:0042255)4.14331779
23purine nucleobase biosynthetic process (GO:0009113)4.14098738
24response to peptidoglycan (GO:0032494)3.96905765
25DNA strand elongation involved in DNA replication (GO:0006271)3.89202969
26regulation of posttranscriptional gene silencing (GO:0060147)3.83710654
27regulation of gene silencing by miRNA (GO:0060964)3.83710654
28regulation of gene silencing by RNA (GO:0060966)3.83710654
29cellular extravasation (GO:0045123)3.83340670
30DNA duplex unwinding (GO:0032508)3.82365265
31mitotic metaphase plate congression (GO:0007080)3.82294134
32DNA geometric change (GO:0032392)3.81300406
33heterochromatin organization (GO:0070828)3.76640956
34protein localization to chromosome, centromeric region (GO:0071459)3.76283415
35DNA replication checkpoint (GO:0000076)3.75887443
36mitotic sister chromatid segregation (GO:0000070)3.73938996
37viral transcription (GO:0019083)3.72528007
383-UTR-mediated mRNA stabilization (GO:0070935)3.70685298
39DNA strand elongation (GO:0022616)3.70198385
40nuclear envelope organization (GO:0006998)3.69568173
41maturation of SSU-rRNA (GO:0030490)3.60803074
42translational termination (GO:0006415)3.57023996
43tRNA methylation (GO:0030488)3.54885085
44positive regulation of chromosome segregation (GO:0051984)3.53788609
45peptidyl-arginine omega-N-methylation (GO:0035247)3.49741926
46ribosomal small subunit assembly (GO:0000028)3.48456468
47negative regulation of histone methylation (GO:0031061)3.46262611
48pseudouridine synthesis (GO:0001522)3.42545499
49sister chromatid segregation (GO:0000819)3.41895518
50negative regulation of B cell apoptotic process (GO:0002903)3.41865861
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.40991378
52tRNA modification (GO:0006400)3.37058233
53ribonucleoprotein complex biogenesis (GO:0022613)3.35379534
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33982096
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33815526
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33045175
57regulation of histone H3-K9 methylation (GO:0051570)3.27930055
58regulation of spindle organization (GO:0090224)3.26433264
59dosage compensation (GO:0007549)3.25642392
60mitotic chromosome condensation (GO:0007076)3.24769811
61translational elongation (GO:0006414)3.22272971
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20818330
63folic acid metabolic process (GO:0046655)3.17724081
64telomere maintenance via semi-conservative replication (GO:0032201)3.17319223
65histone arginine methylation (GO:0034969)3.17112622
66mitotic sister chromatid cohesion (GO:0007064)3.16925748
67metaphase plate congression (GO:0051310)3.15155512
68chromatin assembly (GO:0031497)3.14084753
69rRNA transcription (GO:0009303)3.13275782
70mRNA transport (GO:0051028)3.11112279
71peptidyl-arginine N-methylation (GO:0035246)3.06800619
72peptidyl-arginine methylation (GO:0018216)3.06800619
73regulation of RNA export from nucleus (GO:0046831)3.05254137
74rRNA processing (GO:0006364)3.04807579
75pentose metabolic process (GO:0019321)3.02912616
76histone H2A monoubiquitination (GO:0035518)3.01320010
77mitotic G1 DNA damage checkpoint (GO:0031571)3.00467482
78regulation of mitotic spindle organization (GO:0060236)3.00195638
79spliceosomal snRNP assembly (GO:0000387)3.00159637
80DNA conformation change (GO:0071103)2.99668731
81mitochondrial RNA metabolic process (GO:0000959)2.99037641
82translational initiation (GO:0006413)2.98306070
83rRNA metabolic process (GO:0016072)2.98036630
84chaperone-mediated protein complex assembly (GO:0051131)2.97687497
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96807677
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.95955430
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.95391852
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95391852
89histone H4-K12 acetylation (GO:0043983)2.91659741
90RNA transport (GO:0050658)2.91366968
91establishment of RNA localization (GO:0051236)2.91366968
92nucleic acid transport (GO:0050657)2.91366968
93chromatin assembly or disassembly (GO:0006333)2.90927138
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90395370
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90395370
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.90395370
97regulation of centrosome cycle (GO:0046605)2.85934871
98regulation of chromosome segregation (GO:0051983)2.85824899
99telomere maintenance via recombination (GO:0000722)2.85814432
100mitotic recombination (GO:0006312)2.84231194
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83598707
102mRNA splicing, via spliceosome (GO:0000398)2.83598707
103negative regulation of mRNA processing (GO:0050686)2.83592654
104RNA splicing, via transesterification reactions (GO:0000375)2.83419596
105response to muramyl dipeptide (GO:0032495)2.83134738
106snRNA processing (GO:0016180)2.82293443
107negative regulation of RNA splicing (GO:0033119)2.81989809
108snRNA metabolic process (GO:0016073)2.81586021
109transcription from mitochondrial promoter (GO:0006390)2.81193226
110ncRNA 3-end processing (GO:0043628)2.80169530
111negative regulation of chromosome segregation (GO:0051985)2.80103579
112tRNA aminoacylation for protein translation (GO:0006418)2.76901682
113attachment of spindle microtubules to kinetochore (GO:0008608)2.75971065
114telomere maintenance via telomere lengthening (GO:0010833)2.75245397
115viral life cycle (GO:0019058)2.74445505
116regulation of histone phosphorylation (GO:0033127)2.74395960
117regulation of B cell apoptotic process (GO:0002902)2.74166744
118respiratory burst (GO:0045730)2.73932904
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73781663
120RNA export from nucleus (GO:0006405)2.73322515
121regulation of sister chromatid cohesion (GO:0007063)2.72464701
122ribosomal large subunit biogenesis (GO:0042273)2.72243965
123ncRNA processing (GO:0034470)2.71257392
124NLS-bearing protein import into nucleus (GO:0006607)2.70637079
125cellular protein complex disassembly (GO:0043624)2.70099212
126establishment of chromosome localization (GO:0051303)2.69574799
127protein localization to chromosome (GO:0034502)2.68433504
128regulation of translational elongation (GO:0006448)2.67611505
129necroptotic process (GO:0070266)2.67436161
130postreplication repair (GO:0006301)2.67032523
131protein targeting to ER (GO:0045047)2.65582079
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65560099
133negative regulation of interleukin-12 production (GO:0032695)2.65323850
134neutrophil mediated immunity (GO:0002446)2.64823938
135cellular component biogenesis (GO:0044085)2.63687074
136leukocyte aggregation (GO:0070486)2.61811702
137cotranslational protein targeting to membrane (GO:0006613)2.61459621
138negative regulation of mRNA metabolic process (GO:1903312)2.61285466
139protein complex disassembly (GO:0043241)2.59999834
140apoptotic process involved in morphogenesis (GO:0060561)2.49795076
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.49007763
142negative regulation of erythrocyte differentiation (GO:0045647)2.46447994
143UTP biosynthetic process (GO:0006228)2.46315499
144protein localization to endoplasmic reticulum (GO:0070972)2.45315259
145positive regulation of histone deacetylation (GO:0031065)2.43367835
146negative regulation of interleukin-8 production (GO:0032717)2.43232329
147nuclear envelope reassembly (GO:0031468)2.43212873
148mitotic nuclear envelope reassembly (GO:0007084)2.43212873
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41606746
150macromolecular complex disassembly (GO:0032984)2.40404801
151modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39155047
152positive regulation by organism of defense response of other organism involved in symbiotic interact2.39155047
153modulation by symbiont of host immune response (GO:0052553)2.39155047
154positive regulation by symbiont of host defense response (GO:0052509)2.39155047
155modulation by symbiont of host defense response (GO:0052031)2.39155047
156modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39155047
157ncRNA metabolic process (GO:0034660)2.39098480
158rRNA modification (GO:0000154)2.38632299
159cellular response to interleukin-4 (GO:0071353)2.36735571
160maturation of 5.8S rRNA (GO:0000460)2.34975801
161mRNA stabilization (GO:0048255)2.34135618
162RNA stabilization (GO:0043489)2.34135618
163RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.32484573
164intracellular estrogen receptor signaling pathway (GO:0030520)2.32252071
165nuclear-transcribed mRNA catabolic process (GO:0000956)2.31024106
166mitotic G1/S transition checkpoint (GO:0044819)2.30836612
167tRNA processing (GO:0008033)2.30826078
168positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.30400435
169RNA catabolic process (GO:0006401)2.30039918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69971283
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16912333
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.10044321
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51363310
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23106478
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11784443
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.83679568
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68532426
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65565893
10MYC_22102868_ChIP-Seq_BL_Human2.63039049
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49215549
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29991534
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.20409842
14XRN2_22483619_ChIP-Seq_HELA_Human2.17809970
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16012541
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14351681
17AR_21909140_ChIP-Seq_LNCAP_Human2.01882418
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.99243651
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98261994
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.93049671
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92342287
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90929573
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90124361
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85316114
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83517206
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82212012
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78579680
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72535499
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71891253
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66114702
31CIITA_25753668_ChIP-Seq_RAJI_Human1.64790726
32MAF_26560356_Chip-Seq_TH1_Human1.64537664
33VDR_24763502_ChIP-Seq_THP-1_Human1.62001826
34KDM5A_27292631_Chip-Seq_BREAST_Human1.61463048
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60990709
36VDR_23849224_ChIP-Seq_CD4+_Human1.59641718
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58661059
38LXR_22292898_ChIP-Seq_THP-1_Human1.57813787
39GABP_19822575_ChIP-Seq_HepG2_Human1.57316318
40* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55550512
41P68_20966046_ChIP-Seq_HELA_Human1.54275426
42FOXP3_21729870_ChIP-Seq_TREG_Human1.53645464
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.52312236
44TTF2_22483619_ChIP-Seq_HELA_Human1.50329927
45MAF_26560356_Chip-Seq_TH2_Human1.49828132
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49741697
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49190234
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49152335
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47959212
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46301765
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46025315
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45998240
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45644241
54DCP1A_22483619_ChIP-Seq_HELA_Human1.44075395
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43917216
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.35959923
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33361579
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33242061
59RACK7_27058665_Chip-Seq_MCF-7_Human1.32987456
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32733536
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31392937
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31381859
63VDR_21846776_ChIP-Seq_THP-1_Human1.28976777
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.27986069
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.27950961
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27910618
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27092220
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26910976
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.26598373
70BCOR_27268052_Chip-Seq_Bcells_Human1.26461428
71* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26373857
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25765262
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25072756
74* SPI1_23547873_ChIP-Seq_NB4_Human1.23799392
75ZNF263_19887448_ChIP-Seq_K562_Human1.23724921
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23355482
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22737796
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22709932
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22358487
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21559173
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21115696
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18974954
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18682919
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18435557
85* SA1_27219007_Chip-Seq_ERYTHROID_Human1.17920442
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17790668
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17280337
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16262840
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16106796
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.15364424
91TFEB_21752829_ChIP-Seq_HELA_Human1.15028802
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14777481
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14291455
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13713421
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.13046982
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12990153
97BCL6_27268052_Chip-Seq_Bcells_Human1.11787619
98E2F1_20622854_ChIP-Seq_HELA_Human1.11653174
99* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11349320
100TP53_22127205_ChIP-Seq_IMR90_Human1.09649666
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.09638896
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09610714
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09470176
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08881405
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08381588
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08381588
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08381588
108* PHF8_20622854_ChIP-Seq_HELA_Human1.08255120
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07972308
110NANOG_21062744_ChIP-ChIP_HESCs_Human1.05696754
111TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04100133
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03777024
113* ATF3_27146783_Chip-Seq_COLON_Human1.02749314
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02537209
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01908633
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98739784
117* TCF7_22412390_ChIP-Seq_EML_Mouse0.97716563
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97423905
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.95799164
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94917179
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94344293
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93570235
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90413892
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90325938
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90163598
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90003104
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89497539
128KDM2B_26808549_Chip-Seq_DND41_Human0.88970112
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88636625
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.88497226
131ELK1_19687146_ChIP-ChIP_HELA_Human0.86463500
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86420864
133UTX_26944678_Chip-Seq_JUKART_Human0.86375644
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85127735
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85045975
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84882126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.35975863
2MP0003111_abnormal_nucleus_morphology4.28549413
3MP0010094_abnormal_chromosome_stability4.03596378
4MP0004957_abnormal_blastocyst_morpholog3.97641562
5MP0008057_abnormal_DNA_replication3.78759838
6MP0003077_abnormal_cell_cycle3.59745121
7MP0010352_gastrointestinal_tract_polyps3.46324630
8MP0002009_preneoplasia3.02675467
9MP0001730_embryonic_growth_arrest2.85507050
10MP0003436_decreased_susceptibility_to2.78050841
11MP0008058_abnormal_DNA_repair2.56329255
12MP0008007_abnormal_cellular_replicative2.47951651
13MP0000350_abnormal_cell_proliferation2.47348253
14MP0008877_abnormal_DNA_methylation2.45039227
15MP0003123_paternal_imprinting2.39857478
16MP0010307_abnormal_tumor_latency2.31150028
17MP0005380_embryogenesis_phenotype2.24485012
18MP0001672_abnormal_embryogenesis/_devel2.24485012
19MP0005083_abnormal_biliary_tract2.19359310
20MP0003705_abnormal_hypodermis_morpholog2.17828952
21MP0005076_abnormal_cell_differentiation2.09891143
22MP0003984_embryonic_growth_retardation2.09540320
23MP0002396_abnormal_hematopoietic_system2.07996315
24MP0008932_abnormal_embryonic_tissue2.06214999
25MP0002088_abnormal_embryonic_growth/wei2.04395926
26MP0002254_reproductive_system_inflammat2.03954897
27MP0005451_abnormal_body_composition2.03847612
28MP0001697_abnormal_embryo_size1.97365066
29MP0003172_abnormal_lysosome_physiology1.96658899
30MP0004197_abnormal_fetal_growth/weight/1.93181061
31MP0002084_abnormal_developmental_patter1.92353346
32MP0002085_abnormal_embryonic_tissue1.84353874
33MP0002080_prenatal_lethality1.84237306
34MP0001873_stomach_inflammation1.83536853
35MP0003786_premature_aging1.83065186
36MP0002086_abnormal_extraembryonic_tissu1.79696586
37MP0003890_abnormal_embryonic-extraembry1.73143781
38MP0000685_abnormal_immune_system1.63316596
39MP0002419_abnormal_innate_immunity1.62040225
40MP0004808_abnormal_hematopoietic_stem1.59017512
41MP0006035_abnormal_mitochondrial_morpho1.57971409
42MP0010030_abnormal_orbit_morphology1.56451735
43MP0003283_abnormal_digestive_organ1.49843717
44MP0004233_abnormal_muscle_weight1.48107664
45MP0004947_skin_inflammation1.42002461
46MP0002653_abnormal_ependyma_morphology1.41446787
47MP0009840_abnormal_foam_cell1.41018346
48MP0001835_abnormal_antigen_presentation1.40262092
49MP0005025_abnormal_response_to1.40118083
50MP0003566_abnormal_cell_adhesion1.39107260
51MP0002166_altered_tumor_susceptibility1.37422626
52MP0009278_abnormal_bone_marrow1.36288715
53MP0002420_abnormal_adaptive_immunity1.35955497
54MP0000313_abnormal_cell_death1.35319148
55MP0003303_peritoneal_inflammation1.34708344
56MP0001819_abnormal_immune_cell1.34509892
57MP0002006_tumorigenesis1.30463793
58MP0001545_abnormal_hematopoietic_system1.29719647
59MP0005397_hematopoietic_system_phenotyp1.29719647
60MP0002269_muscular_atrophy1.27721648
61MP0000015_abnormal_ear_pigmentation1.26370904
62MP0002019_abnormal_tumor_incidence1.26365907
63MP0000750_abnormal_muscle_regeneration1.26140216
64MP0001800_abnormal_humoral_immune1.25840129
65MP0002452_abnormal_antigen_presenting1.24616756
66MP0002723_abnormal_immune_serum1.24226835
67MP0000470_abnormal_stomach_morphology1.23608309
68MP0000733_abnormal_muscle_development1.21955788
69MP0000490_abnormal_crypts_of1.21338332
70MP0002405_respiratory_system_inflammati1.19532508
71MP0002429_abnormal_blood_cell1.19056974
72MP0003119_abnormal_digestive_system1.16592183
73MP0003567_abnormal_fetal_cardiomyocyte1.16226600
74MP0009672_abnormal_birth_weight1.15807668
75MP0005058_abnormal_lysosome_morphology1.15382778
76MP0000537_abnormal_urethra_morphology1.13579555
77MP0005000_abnormal_immune_tolerance1.13348156
78MP0008260_abnormal_autophagy1.12198605
79MP0000716_abnormal_immune_system1.11186544
80MP0003828_pulmonary_edema1.10411959
81MP0005023_abnormal_wound_healing1.08486483
82MP0002210_abnormal_sex_determination1.08070595
83MP0003763_abnormal_thymus_physiology1.06173464
84MP0003121_genomic_imprinting1.05898892
85MP0003221_abnormal_cardiomyocyte_apopto1.05195294
86MP0000703_abnormal_thymus_morphology1.05009203
87MP0005310_abnormal_salivary_gland1.02095331
88MP0006292_abnormal_olfactory_placode1.01649702
89MP0001533_abnormal_skeleton_physiology1.00527214
90MP0001986_abnormal_taste_sensitivity1.00435487
91MP0005499_abnormal_olfactory_system0.98120466
92MP0005394_taste/olfaction_phenotype0.98120466
93MP0001293_anophthalmia0.97731470
94MP0002148_abnormal_hypersensitivity_rea0.97578314
95MP0002277_abnormal_respiratory_mucosa0.97563322
96MP0004381_abnormal_hair_follicle0.96076379
97MP0001145_abnormal_male_reproductive0.95544278
98MP0003718_maternal_effect0.95376991
99MP0000428_abnormal_craniofacial_morphol0.95304895
100MP0008995_early_reproductive_senescence0.95173822
101MP0008770_decreased_survivor_rate0.94753083
102MP0009785_altered_susceptibility_to0.93303488
103MP0006036_abnormal_mitochondrial_physio0.93102317
104MP0001849_ear_inflammation0.92859439
105MP0004084_abnormal_cardiac_muscle0.92517335
106MP0000358_abnormal_cell_content/0.91323492
107MP0001929_abnormal_gametogenesis0.91271092
108MP0005621_abnormal_cell_physiology0.91130378
109MP0009703_decreased_birth_body0.90334809
110MP0003646_muscle_fatigue0.89841161
111MP0005501_abnormal_skin_physiology0.88884454
112MP0001790_abnormal_immune_system0.87982116
113MP0005387_immune_system_phenotype0.87982116
114MP0009333_abnormal_splenocyte_physiolog0.86827992
115MP0005384_cellular_phenotype0.86652823
116MP0002132_abnormal_respiratory_system0.86415524
117MP0004087_abnormal_muscle_fiber0.86034094
118MP0001915_intracranial_hemorrhage0.85233557
119MP0002796_impaired_skin_barrier0.85197842
120MP0000747_muscle_weakness0.83507117
121MP0005671_abnormal_response_to0.81637710
122MP0010630_abnormal_cardiac_muscle0.80745684
123MP0004133_heterotaxia0.79998433
124MP0002163_abnormal_gland_morphology0.79628204
125MP0001853_heart_inflammation0.79288854
126MP0002332_abnormal_exercise_endurance0.79149733
127MP0000579_abnormal_nail_morphology0.78697594
128MP0002092_abnormal_eye_morphology0.78468824
129MP0002925_abnormal_cardiovascular_devel0.78287191
130MP0002111_abnormal_tail_morphology0.77528681
131MP0009053_abnormal_anal_canal0.77493430
132MP0002722_abnormal_immune_system0.77248821
133MP0008961_abnormal_basal_metabolism0.76930102
134MP0000266_abnormal_heart_morphology0.75866662
135MP0000653_abnormal_sex_gland0.75701722
136MP0004858_abnormal_nervous_system0.75542658
137MP0002398_abnormal_bone_marrow0.75106189
138MP0002877_abnormal_melanocyte_morpholog0.74649134
139MP0008789_abnormal_olfactory_epithelium0.70186400
140MP0002106_abnormal_muscle_physiology0.69865361
141MP0000689_abnormal_spleen_morphology0.69503623
142MP0000759_abnormal_skeletal_muscle0.68726885
143MP0004185_abnormal_adipocyte_glucose0.68701063
144MP0003878_abnormal_ear_physiology0.67865663
145MP0005377_hearing/vestibular/ear_phenot0.67865663
146MP0003941_abnormal_skin_development0.66261037
147MP0000858_altered_metastatic_potential0.65451591
148MP0003861_abnormal_nervous_system0.65080120
149MP0003806_abnormal_nucleotide_metabolis0.64783884
150MP0005266_abnormal_metabolism0.64736843
151MP0005623_abnormal_meninges_morphology0.64602792
152MP0002697_abnormal_eye_size0.64384144
153MP0003935_abnormal_craniofacial_develop0.64174600

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.80973871
2Abnormality of cells of the erythroid lineage (HP:0012130)4.67348322
3Ependymoma (HP:0002888)4.36921929
4Selective tooth agenesis (HP:0001592)3.73707772
5Hypoplasia of the pons (HP:0012110)3.49520101
6Stomatitis (HP:0010280)3.48105360
7Birth length less than 3rd percentile (HP:0003561)3.47718863
8Elevated erythrocyte sedimentation rate (HP:0003565)3.44715196
9Abnormality of the columella (HP:0009929)3.43505503
10Reticulocytopenia (HP:0001896)3.39872024
11Abnormality of the pons (HP:0007361)3.37494768
12Microvesicular hepatic steatosis (HP:0001414)3.26621244
13Thrombocytosis (HP:0001894)3.24753225
14Abnormality of the astrocytes (HP:0100707)3.21011711
15Astrocytoma (HP:0009592)3.21011711
16Abnormality of the lower motor neuron (HP:0002366)3.09392821
17Medulloblastoma (HP:0002885)2.94088061
18Degeneration of anterior horn cells (HP:0002398)2.87515167
19Abnormality of the anterior horn cell (HP:0006802)2.87515167
20Myositis (HP:0100614)2.83811387
21Microretrognathia (HP:0000308)2.74749266
22Recurrent cutaneous fungal infections (HP:0011370)2.74020565
23Chronic mucocutaneous candidiasis (HP:0002728)2.74020565
24Increased serum ferritin (HP:0003281)2.66229329
25Colon cancer (HP:0003003)2.64868346
26Abnormality of the labia minora (HP:0012880)2.63798952
27Impulsivity (HP:0100710)2.63565746
28Patellar aplasia (HP:0006443)2.63439027
29Ragged-red muscle fibers (HP:0003200)2.62288037
30Difficulty climbing stairs (HP:0003551)2.61696633
31Abnormality of the calcaneus (HP:0008364)2.59967548
32Breast hypoplasia (HP:0003187)2.59769895
33Pallor (HP:0000980)2.58338068
34Glioma (HP:0009733)2.56449390
35Type II lissencephaly (HP:0007260)2.55184204
36Rhabdomyosarcoma (HP:0002859)2.54742828
37Cerebellar dysplasia (HP:0007033)2.53797985
38Pelvic girdle muscle weakness (HP:0003749)2.51098225
39Cleft eyelid (HP:0000625)2.51098036
40Missing ribs (HP:0000921)2.49442406
41Deviation of the thumb (HP:0009603)2.47498632
42Aplasia/Hypoplasia of the patella (HP:0006498)2.47194040
43Orchitis (HP:0100796)2.47111518
44Trismus (HP:0000211)2.43867858
45Increased connective tissue (HP:0009025)2.43687065
46Cheilitis (HP:0100825)2.42922368
47Basal cell carcinoma (HP:0002671)2.40985213
48Proximal placement of thumb (HP:0009623)2.39411331
49Chromsome breakage (HP:0040012)2.37044968
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.36598725
51Hyperacusis (HP:0010780)2.35807816
52Cerebral hypomyelination (HP:0006808)2.33864272
53Ureteral duplication (HP:0000073)2.32651421
54Neoplasm of striated muscle (HP:0009728)2.32022849
55Prominent nose (HP:0000448)2.32001490
56Increased nuchal translucency (HP:0010880)2.31840023
57Multiple enchondromatosis (HP:0005701)2.30633687
58Progressive external ophthalmoplegia (HP:0000590)2.30495050
59Retrobulbar optic neuritis (HP:0100654)2.30365818
60Optic neuritis (HP:0100653)2.30365818
61Premature ovarian failure (HP:0008209)2.27785776
62Rectal prolapse (HP:0002035)2.26817910
63Abnormal number of incisors (HP:0011064)2.26661070
64Long palpebral fissure (HP:0000637)2.25938537
65Severe muscular hypotonia (HP:0006829)2.24205295
66Agnosia (HP:0010524)2.22636048
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21683133
68Abnormality of reticulocytes (HP:0004312)2.20853128
69Recurrent fungal infections (HP:0002841)2.20206123
70Shoulder girdle muscle weakness (HP:0003547)2.18278501
71Abnormality of T cell physiology (HP:0011840)2.16747817
72Deep palmar crease (HP:0006191)2.16317638
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16060755
74Progressive muscle weakness (HP:0003323)2.14067599
75Fibular aplasia (HP:0002990)2.13659591
76Short thumb (HP:0009778)2.12376037
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.11840234
78Carpal bone hypoplasia (HP:0001498)2.11072876
79Horseshoe kidney (HP:0000085)2.09071746
80Increased cerebral lipofuscin (HP:0011813)2.09036367
81Abnormality of the hip-girdle musculature (HP:0001445)2.06828762
82Abnormality of the musculature of the pelvis (HP:0001469)2.06828762
83Rough bone trabeculation (HP:0100670)2.06707599
84Neoplasm of the oral cavity (HP:0100649)2.05759170
85Absent thumb (HP:0009777)2.05520718
86Rib fusion (HP:0000902)2.05308119
87Cafe-au-lait spot (HP:0000957)2.04376266
88Hypochromic anemia (HP:0001931)2.04333281
89Mediastinal lymphadenopathy (HP:0100721)2.02961514
90Spinal muscular atrophy (HP:0007269)2.02505563
91Amaurosis fugax (HP:0100576)2.02076612
92Urethral obstruction (HP:0000796)2.00280303
93Ulnar deviation of the wrist (HP:0003049)2.00167256
94Abnormality of iron homeostasis (HP:0011031)1.99435907
95Aplasia/hypoplasia of the humerus (HP:0006507)1.99363816
96Absent radius (HP:0003974)1.98186827
97Partial agenesis of the corpus callosum (HP:0001338)1.96846293
98Preauricular skin tag (HP:0000384)1.96764798
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.96533489
100Oral leukoplakia (HP:0002745)1.95824982
101Dysmetric saccades (HP:0000641)1.94649735
102Skin tags (HP:0010609)1.94542851
103Neoplasm of the pancreas (HP:0002894)1.92123732
104Increased density of long bones (HP:0006392)1.90797944
105Atresia of the external auditory canal (HP:0000413)1.90399793
106Abnormality of chromosome stability (HP:0003220)1.90397438
107Distal upper limb amyotrophy (HP:0007149)1.90039096
108Upper limb amyotrophy (HP:0009129)1.90039096
109Short humerus (HP:0005792)1.88708986
110Myelodysplasia (HP:0002863)1.88436569
111Overlapping toe (HP:0001845)1.88187495
112Ectopic kidney (HP:0000086)1.87816584
113Severe visual impairment (HP:0001141)1.87611104
114Aplasia involving forearm bones (HP:0009822)1.86902939
115Absent forearm bone (HP:0003953)1.86902939
116Recurrent bacterial skin infections (HP:0005406)1.86767411
117Hand muscle atrophy (HP:0009130)1.86698506
118Obstructive lung disease (HP:0006536)1.86091371
119Chronic obstructive pulmonary disease (HP:0006510)1.86091371
120High pitched voice (HP:0001620)1.85742333
12111 pairs of ribs (HP:0000878)1.85439882
122Arterial thrombosis (HP:0004420)1.84044249
123Abnormality of subcutaneous fat tissue (HP:0001001)1.83889551
124Radial bowing (HP:0002986)1.83682189
125Short palpebral fissure (HP:0012745)1.82566241
126Myopathic facies (HP:0002058)1.82519899
127Adenoma sebaceum (HP:0009720)1.82366860
128Angiofibromas (HP:0010615)1.82366860
129Areflexia of lower limbs (HP:0002522)1.82006929
130Duplicated collecting system (HP:0000081)1.81751713
131Slender long bone (HP:0003100)1.80539180
132Pseudobulbar signs (HP:0002200)1.80517115
133Pendular nystagmus (HP:0012043)1.80442252
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80376615
135Encephalitis (HP:0002383)1.80136119
136Abnormality of transition element cation homeostasis (HP:0011030)1.79695625
137Long eyelashes (HP:0000527)1.79428940
138Personality changes (HP:0000751)1.79083277
139Clumsiness (HP:0002312)1.79058326
140Abnormality of macrophages (HP:0004311)1.78987449
141Achilles tendon contracture (HP:0001771)1.78821723
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78230719
143Broad distal phalanx of finger (HP:0009836)1.77991684
144Recurrent abscess formation (HP:0002722)1.77913928
145Calcaneovalgus deformity (HP:0001848)1.77893535
146Abnormality of the preputium (HP:0100587)1.77508294
147Meckel diverticulum (HP:0002245)1.76310630
148Resting tremor (HP:0002322)1.75479576
149Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73921211
150Squamous cell carcinoma (HP:0002860)1.73274849
151Muscle fibrillation (HP:0010546)1.72602767
152Large for gestational age (HP:0001520)1.72427745
153Distal lower limb amyotrophy (HP:0008944)1.70996599
154Amyloidosis (HP:0011034)1.70910873
155Metaphyseal cupping (HP:0003021)1.70460348
156Renal duplication (HP:0000075)1.70400634
157Patellar dislocation (HP:0002999)1.70297157
158Abnormality of the ileum (HP:0001549)1.70107539
159Secondary amenorrhea (HP:0000869)1.69660629
160Muscle fiber inclusion bodies (HP:0100299)1.68983543
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.68323418
162Facial hemangioma (HP:0000329)1.68195927
163Self-mutilation (HP:0000742)1.67594212
164Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67559944
165Concave nail (HP:0001598)1.67011178
166Aplasia/Hypoplasia of the sternum (HP:0006714)1.66953435
167Congenital hip dislocation (HP:0001374)1.66834708
168Abnormality of chromosome segregation (HP:0002916)1.66718112
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66700528
170Short 4th metacarpal (HP:0010044)1.66700528
171Supernumerary bones of the axial skeleton (HP:0009144)1.66585713
172Broad hallux (HP:0010055)1.66565836
173Optic nerve coloboma (HP:0000588)1.65416238
174Aplasia/Hypoplasia of the thymus (HP:0010515)1.64830344
175Neoplasm of the adrenal cortex (HP:0100641)1.64506371
176Reticulocytosis (HP:0001923)1.64475756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.92982057
2CDC73.87262829
3SMG13.62513813
4BUB13.47497438
5EEF2K3.20714828
6TSSK62.98384736
7IRAK32.86466903
8WEE12.79857216
9NEK12.60645849
10NEK22.57365657
11IRAK42.43279158
12TTK2.15928161
13EPHA22.15004657
14EIF2AK12.05405756
15TRIB32.04230203
16ALK1.96210811
17TTN1.94638903
18RPS6KB21.92660092
19INSRR1.78854843
20PLK11.65946537
21VRK21.64569889
22LATS21.64392309
23MAP3K101.63938091
24CDK71.61025810
25PKN21.57251321
26CAMK1D1.55915645
27CDK41.55454839
28ERN11.54559647
29ATR1.50685613
30MAP3K81.49527218
31MAP2K21.46554939
32PASK1.46552087
33* CHEK11.43366397
34TAOK11.43029913
35STK101.39606699
36PRPF4B1.34587124
37SCYL21.33938984
38AURKB1.33067648
39TAOK21.32937520
40MAP2K31.30184933
41RPS6KA41.29465160
42MAP3K141.29015854
43SRPK11.27639204
44BRD41.25580717
45PDK31.25379110
46PDK41.25379110
47MTOR1.22755775
48MAP3K131.21020724
49ICK1.20259267
50SIK11.20128054
51NME11.18957963
52CHEK21.18669435
53PAK41.18367221
54PLK31.12398633
55MAP3K111.11739891
56IRAK21.08842195
57MAP4K11.08700726
58ACVR1B1.08440284
59IKBKB1.07849823
60CDK21.06681053
61PRKD21.04825345
62TESK21.03926850
63MARK31.03391219
64RPS6KA61.02574796
65TXK1.01979891
66BRSK21.01244071
67PIM11.00455896
68TBK10.99754126
69MAP3K30.98456376
70MAP3K90.97789586
71RIPK40.95601371
72RPS6KL10.93149997
73RPS6KC10.93149997
74AURKA0.92320759
75ATM0.91799391
76MKNK10.91740053
77PLK40.91191006
78BRSK10.90599282
79TNK20.89166270
80TLK10.88387117
81NME20.85701719
82PRKD30.84085651
83PAK20.82834788
84IRAK10.82723746
85TESK10.81521976
86KIT0.81015138
87MKNK20.80317477
88WNK40.79274037
89CHUK0.78648682
90AKT20.76243868
91BTK0.75063099
92MELK0.71170117
93CDK60.70537829
94PAK10.70512157
95CDK10.68245622
96MARK20.66953112
97TYRO30.66682581
98MAPKAPK30.65143328
99* CSNK1E0.64847812
100BMX0.64728549
101CAMK1G0.64074140
102MAP3K10.63421902
103KSR20.63159468
104PNCK0.62644916
105LATS10.62487964
106STK30.62256367
107RPS6KA50.61695467
108* CSNK2A20.60294969
109STK40.59451097
110TGFBR10.58462436
111ZAK0.57191223
112BRAF0.55902828
113GRK60.55287030
114CDK80.55009461
115PDPK10.54947348
116MOS0.54619767
117PDGFRA0.52425818
118RIPK10.51951729
119MAP3K50.51696802
120CDK190.51696474
121EIF2AK30.51393540
122RPS6KA20.50903915
123DYRK30.50686004
124MAP2K60.49245983
125HCK0.48790205
126LRRK20.48695201
127CSNK1D0.48615180
128PIM20.47255700
129PRKDC0.46745194
130JAK30.46381441
131FGFR10.46241775
132CLK10.45984078
133VRK10.45908104
134IKBKE0.45575675
135PRKCI0.45392092
136ARAF0.45294122
137MAPK110.45238863
138STK38L0.44455104
139FLT30.43392059
140PDK20.40158468
141MAPK140.39845422
142TYK20.39098804
143MAPK150.38649817
144RPS6KA10.38054585
145RPS6KB10.34353482
146GSK3B0.33620824
147ZAP700.33105251
148RAF10.32028994
149CSNK2A10.31985926
150CCNB10.31295090
151PTK60.30671407

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.43491046
2DNA replication_Homo sapiens_hsa030304.10784207
3RNA transport_Homo sapiens_hsa030133.67964864
4Mismatch repair_Homo sapiens_hsa034303.32796598
5One carbon pool by folate_Homo sapiens_hsa006703.22275837
6Spliceosome_Homo sapiens_hsa030403.15185958
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.13684473
8Cell cycle_Homo sapiens_hsa041102.60730458
9RNA polymerase_Homo sapiens_hsa030202.53247008
10Base excision repair_Homo sapiens_hsa034102.47278366
11mRNA surveillance pathway_Homo sapiens_hsa030152.24425813
12Nucleotide excision repair_Homo sapiens_hsa034202.23803412
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16621377
14Homologous recombination_Homo sapiens_hsa034401.96950802
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72105983
16RNA degradation_Homo sapiens_hsa030181.70636772
17Pyrimidine metabolism_Homo sapiens_hsa002401.68539464
18Proteasome_Homo sapiens_hsa030501.59823845
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59413404
20Other glycan degradation_Homo sapiens_hsa005111.58886820
21Fanconi anemia pathway_Homo sapiens_hsa034601.57085787
22p53 signaling pathway_Homo sapiens_hsa041151.55049501
23Biosynthesis of amino acids_Homo sapiens_hsa012301.53599093
24Ribosome_Homo sapiens_hsa030101.46225010
25Non-homologous end-joining_Homo sapiens_hsa034501.41418111
26Basal transcription factors_Homo sapiens_hsa030221.40798645
27B cell receptor signaling pathway_Homo sapiens_hsa046621.36356707
28Osteoclast differentiation_Homo sapiens_hsa043801.32423668
29Vitamin B6 metabolism_Homo sapiens_hsa007501.28798288
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28090798
31Epstein-Barr virus infection_Homo sapiens_hsa051691.25557590
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24306467
33Viral carcinogenesis_Homo sapiens_hsa052031.20147464
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19179589
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.17571921
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16503092
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14761136
38Oocyte meiosis_Homo sapiens_hsa041141.13557257
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09184848
40Leishmaniasis_Homo sapiens_hsa051401.07587338
41mTOR signaling pathway_Homo sapiens_hsa041501.06821290
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.06435896
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05067736
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04700506
45TNF signaling pathway_Homo sapiens_hsa046681.04190274
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.03860450
47MicroRNAs in cancer_Homo sapiens_hsa052061.03334606
48HTLV-I infection_Homo sapiens_hsa051661.03084271
49Selenocompound metabolism_Homo sapiens_hsa004500.98875613
50Chronic myeloid leukemia_Homo sapiens_hsa052200.91142840
51Thyroid cancer_Homo sapiens_hsa052160.90961878
52Pentose phosphate pathway_Homo sapiens_hsa000300.90846389
53Purine metabolism_Homo sapiens_hsa002300.87867853
54Small cell lung cancer_Homo sapiens_hsa052220.87756764
55Systemic lupus erythematosus_Homo sapiens_hsa053220.87680678
56Sulfur relay system_Homo sapiens_hsa041220.84733211
57Herpes simplex infection_Homo sapiens_hsa051680.84587235
58Antigen processing and presentation_Homo sapiens_hsa046120.84340297
59Notch signaling pathway_Homo sapiens_hsa043300.84216748
60Hippo signaling pathway_Homo sapiens_hsa043900.83440231
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83342290
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80357451
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76893126
64Primary immunodeficiency_Homo sapiens_hsa053400.75755993
65HIF-1 signaling pathway_Homo sapiens_hsa040660.72997011
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72945764
67Carbon metabolism_Homo sapiens_hsa012000.72694168
68Acute myeloid leukemia_Homo sapiens_hsa052210.70987810
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70347602
70Tuberculosis_Homo sapiens_hsa051520.70049321
71Fructose and mannose metabolism_Homo sapiens_hsa000510.69083389
72Colorectal cancer_Homo sapiens_hsa052100.67255577
73Adherens junction_Homo sapiens_hsa045200.64276257
74Bladder cancer_Homo sapiens_hsa052190.61614776
75Basal cell carcinoma_Homo sapiens_hsa052170.61431374
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60532046
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60301571
78Pancreatic cancer_Homo sapiens_hsa052120.59895575
79Viral myocarditis_Homo sapiens_hsa054160.58732744
80Toxoplasmosis_Homo sapiens_hsa051450.58699496
81Apoptosis_Homo sapiens_hsa042100.58443241
82Legionellosis_Homo sapiens_hsa051340.58119097
83Hepatitis C_Homo sapiens_hsa051600.56732329
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55166263
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54802759
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.54356077
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.53964209
88Renal cell carcinoma_Homo sapiens_hsa052110.52181700
89TGF-beta signaling pathway_Homo sapiens_hsa043500.51381300
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51330679
91Lysine degradation_Homo sapiens_hsa003100.51308480
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51044348
93MAPK signaling pathway_Homo sapiens_hsa040100.50144113
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46245942
95Proteoglycans in cancer_Homo sapiens_hsa052050.46118111
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45966744
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45426180
98Hepatitis B_Homo sapiens_hsa051610.45261058
99Non-small cell lung cancer_Homo sapiens_hsa052230.44481151
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43969466
101Galactose metabolism_Homo sapiens_hsa000520.43610934
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.42555116
103Shigellosis_Homo sapiens_hsa051310.42028451
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41894109
105Endometrial cancer_Homo sapiens_hsa052130.41442546
106Insulin resistance_Homo sapiens_hsa049310.41124137
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.40774376
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40601298
109T cell receptor signaling pathway_Homo sapiens_hsa046600.40414745
110Tight junction_Homo sapiens_hsa045300.39818474
111Type II diabetes mellitus_Homo sapiens_hsa049300.39650881
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39458814
113ErbB signaling pathway_Homo sapiens_hsa040120.38618582
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37629299
115Prolactin signaling pathway_Homo sapiens_hsa049170.37369061
116Glucagon signaling pathway_Homo sapiens_hsa049220.37239696
117Folate biosynthesis_Homo sapiens_hsa007900.37078962
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36730103
119Pathways in cancer_Homo sapiens_hsa052000.34544084
120VEGF signaling pathway_Homo sapiens_hsa043700.33722253
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32685921
122Hedgehog signaling pathway_Homo sapiens_hsa043400.31835506
123Prostate cancer_Homo sapiens_hsa052150.31824769
124Glioma_Homo sapiens_hsa052140.31594708
125Measles_Homo sapiens_hsa051620.30012137
126Insulin signaling pathway_Homo sapiens_hsa049100.29778741
127Influenza A_Homo sapiens_hsa051640.29361973
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.28662520
129AMPK signaling pathway_Homo sapiens_hsa041520.28438791
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26106435
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25370440
132Alcoholism_Homo sapiens_hsa050340.25174787

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