RRP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.89783267
2DNA deamination (GO:0045006)4.80359985
3nucleobase biosynthetic process (GO:0046112)4.69156575
4formation of translation preinitiation complex (GO:0001731)4.65930381
5ribosomal small subunit assembly (GO:0000028)4.60541828
6purine nucleobase biosynthetic process (GO:0009113)4.55908679
7ribosome biogenesis (GO:0042254)4.50739265
8DNA strand elongation involved in DNA replication (GO:0006271)4.48522925
9ribosomal large subunit biogenesis (GO:0042273)4.45548828
10DNA replication initiation (GO:0006270)4.40561494
11ribosome assembly (GO:0042255)4.35519601
12ribonucleoprotein complex biogenesis (GO:0022613)4.34227100
13DNA strand elongation (GO:0022616)4.27873721
14DNA double-strand break processing (GO:0000729)4.27429932
15telomere maintenance via semi-conservative replication (GO:0032201)4.25118974
16DNA replication checkpoint (GO:0000076)4.22040518
17mitotic metaphase plate congression (GO:0007080)4.21565979
18ribosomal small subunit biogenesis (GO:0042274)4.06164728
19viral transcription (GO:0019083)3.98787227
20translational termination (GO:0006415)3.97028837
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.95126349
22rRNA processing (GO:0006364)3.87419340
23DNA unwinding involved in DNA replication (GO:0006268)3.87371442
24regulation of mitotic spindle checkpoint (GO:1903504)3.85374006
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.85374006
26chaperone-mediated protein transport (GO:0072321)3.80575310
27telomere maintenance via recombination (GO:0000722)3.79878072
28IMP biosynthetic process (GO:0006188)3.79379509
29protein localization to kinetochore (GO:0034501)3.79193754
30replication fork processing (GO:0031297)3.79165036
31pseudouridine synthesis (GO:0001522)3.78305592
32translational initiation (GO:0006413)3.75518571
33rRNA metabolic process (GO:0016072)3.75425730
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.74820574
35mitotic nuclear envelope disassembly (GO:0007077)3.69404736
36translational elongation (GO:0006414)3.67898964
37folic acid-containing compound biosynthetic process (GO:0009396)3.67340400
38proteasome assembly (GO:0043248)3.67106544
39spliceosomal snRNP assembly (GO:0000387)3.66631978
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66272458
41CENP-A containing nucleosome assembly (GO:0034080)3.63244853
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.62971949
43metaphase plate congression (GO:0051310)3.61606019
44chromatin remodeling at centromere (GO:0031055)3.60820690
45telomere maintenance via telomere lengthening (GO:0010833)3.59342945
46water-soluble vitamin biosynthetic process (GO:0042364)3.58360471
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57511341
48mitotic recombination (GO:0006312)3.57448615
49rRNA modification (GO:0000154)3.56924969
50respiratory chain complex IV assembly (GO:0008535)3.55033320
51DNA replication-dependent nucleosome assembly (GO:0006335)3.49403321
52DNA replication-dependent nucleosome organization (GO:0034723)3.49403321
53nuclear pore organization (GO:0006999)3.46017582
54termination of RNA polymerase III transcription (GO:0006386)3.44006985
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.44006985
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41046456
57nuclear envelope disassembly (GO:0051081)3.40947795
58membrane disassembly (GO:0030397)3.40947795
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.39771936
60isotype switching (GO:0045190)3.39771936
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.39771936
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39738985
63folic acid metabolic process (GO:0046655)3.38682660
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38544103
65mitochondrial respiratory chain complex assembly (GO:0033108)3.37444332
66protein complex biogenesis (GO:0070271)3.36375816
67kinetochore organization (GO:0051383)3.36183970
68regulation of DNA endoreduplication (GO:0032875)3.35256237
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34486060
70cullin deneddylation (GO:0010388)3.34033642
71DNA replication-independent nucleosome assembly (GO:0006336)3.31594647
72DNA replication-independent nucleosome organization (GO:0034724)3.31594647
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30650761
74IMP metabolic process (GO:0046040)3.29820611
75maturation of 5.8S rRNA (GO:0000460)3.29691895
76synapsis (GO:0007129)3.29513689
77cotranslational protein targeting to membrane (GO:0006613)3.29326061
78protein targeting to ER (GO:0045047)3.28902568
79protein localization to chromosome, centromeric region (GO:0071459)3.28727781
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27371591
81cellular component biogenesis (GO:0044085)3.25102032
82transcription-coupled nucleotide-excision repair (GO:0006283)3.24095656
83regulation of nuclear cell cycle DNA replication (GO:0033262)3.24036358
84cytochrome complex assembly (GO:0017004)3.23674377
85kinetochore assembly (GO:0051382)3.23290058
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23016350
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.22805528
88viral mRNA export from host cell nucleus (GO:0046784)3.20899301
89termination of RNA polymerase I transcription (GO:0006363)3.20896326
90translation (GO:0006412)3.17673981
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15982147
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.15982147
93NADH dehydrogenase complex assembly (GO:0010257)3.15982147
94nuclear pore complex assembly (GO:0051292)3.14408788
95protein deneddylation (GO:0000338)3.13258387
96DNA catabolic process, exonucleolytic (GO:0000738)3.12964204
97cellular protein complex disassembly (GO:0043624)3.12901391
98establishment of chromosome localization (GO:0051303)3.12095517
99transcription from RNA polymerase I promoter (GO:0006360)3.11147585
100spliceosomal complex assembly (GO:0000245)3.10897341
101establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10714947
102telomere maintenance via telomerase (GO:0007004)3.10354528
103protein localization to endoplasmic reticulum (GO:0070972)3.10163924
104protein K6-linked ubiquitination (GO:0085020)3.08476503
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.08398502
106somatic hypermutation of immunoglobulin genes (GO:0016446)3.07314953
107somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07314953
108G1/S transition of mitotic cell cycle (GO:0000082)3.06772864
109cell cycle G1/S phase transition (GO:0044843)3.06772864
110viral life cycle (GO:0019058)3.06637523
111regulation of centriole replication (GO:0046599)3.05976170
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04743126
113negative regulation of ligase activity (GO:0051352)3.04743126
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04637597
1157-methylguanosine mRNA capping (GO:0006370)3.03803110
116regulation of spindle organization (GO:0090224)3.03486573
117histone exchange (GO:0043486)3.02481055
118ncRNA processing (GO:0034470)3.02048209
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01569836
120DNA damage response, detection of DNA damage (GO:0042769)3.01439537
121regulation of mitochondrial translation (GO:0070129)2.97576246
1227-methylguanosine RNA capping (GO:0009452)2.97453139
123RNA capping (GO:0036260)2.97453139
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97263835
125attachment of spindle microtubules to kinetochore (GO:0008608)2.96155141
126double-strand break repair via nonhomologous end joining (GO:0006303)2.94338175
127non-recombinational repair (GO:0000726)2.94338175
128negative regulation of chromosome segregation (GO:0051985)2.93241527
129ncRNA metabolic process (GO:0034660)2.93081030
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92390554
131establishment of integrated proviral latency (GO:0075713)2.92061466
132somatic recombination of immunoglobulin gene segments (GO:0016447)2.91914601
133DNA-templated transcription, termination (GO:0006353)2.91805907
134mitotic sister chromatid segregation (GO:0000070)2.91632085
135protein neddylation (GO:0045116)2.91431624
136negative regulation of sister chromatid segregation (GO:0033046)2.90807553
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.90807553
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90807553
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90807553
140RNA splicing, via transesterification reactions (GO:0000375)2.90286013
141rRNA methylation (GO:0031167)2.90113036
142ATP synthesis coupled proton transport (GO:0015986)2.86799643
143energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86799643
144recombinational repair (GO:0000725)2.86215952
145double-strand break repair via homologous recombination (GO:0000724)2.85383712
146regulation of helicase activity (GO:0051095)2.84920473
147histone mRNA metabolic process (GO:0008334)2.83332796
148somatic diversification of immunoglobulins (GO:0016445)2.77369813
149lactate metabolic process (GO:0006089)2.76579412
150postreplication repair (GO:0006301)2.71955976
151spindle checkpoint (GO:0031577)2.71667905
152mitochondrial RNA metabolic process (GO:0000959)2.69459384
153resolution of meiotic recombination intermediates (GO:0000712)2.68562566
154transcription from mitochondrial promoter (GO:0006390)2.68496180
155protein targeting to mitochondrion (GO:0006626)2.64974122
156DNA-dependent DNA replication (GO:0006261)2.64746247
157mitotic spindle checkpoint (GO:0071174)2.62874339
158RNA-dependent DNA replication (GO:0006278)2.58098597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.54499310
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.68912898
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74858382
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45077497
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36609651
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.34988374
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25766992
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.18535928
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14883718
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.14458191
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.07846462
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.05702893
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04221701
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93093293
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84387228
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.70361447
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50178823
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45399071
19ZNF274_21170338_ChIP-Seq_K562_Hela2.44727899
20* XRN2_22483619_ChIP-Seq_HELA_Human2.42329533
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39573990
22* VDR_23849224_ChIP-Seq_CD4+_Human2.34648449
23EWS_26573619_Chip-Seq_HEK293_Human2.30675989
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26626470
25VDR_22108803_ChIP-Seq_LS180_Human2.20701772
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14764837
27DCP1A_22483619_ChIP-Seq_HELA_Human2.11672230
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09023605
29FUS_26573619_Chip-Seq_HEK293_Human2.08106451
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06205590
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.05959324
32* FOXP3_21729870_ChIP-Seq_TREG_Human2.03563690
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03174654
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00600718
35AR_21909140_ChIP-Seq_LNCAP_Human1.98826812
36* GABP_19822575_ChIP-Seq_HepG2_Human1.95883891
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95388271
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95263122
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93535585
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91893166
41TTF2_22483619_ChIP-Seq_HELA_Human1.91880651
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84765059
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.83643104
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82397811
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78178300
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76574063
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73258450
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71913226
49ELK1_19687146_ChIP-ChIP_HELA_Human1.70285628
50* YY1_21170310_ChIP-Seq_MESCs_Mouse1.67149938
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66694747
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65932887
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62398500
54* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61599600
55P300_19829295_ChIP-Seq_ESCs_Human1.61229422
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61174487
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58930510
58TAF15_26573619_Chip-Seq_HEK293_Human1.58389155
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58300162
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57727887
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57070159
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.56863346
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56424341
64IGF1R_20145208_ChIP-Seq_DFB_Human1.54236470
65KDM5A_27292631_Chip-Seq_BREAST_Human1.53029486
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52929922
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52178135
68CIITA_25753668_ChIP-Seq_RAJI_Human1.48907864
69* SRF_21415370_ChIP-Seq_HL-1_Mouse1.47227641
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39659614
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39559813
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39348004
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35866741
74MYC_22102868_ChIP-Seq_BL_Human1.35363195
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.33869088
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31554579
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30647868
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29161936
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29036903
80* NOTCH1_21737748_ChIP-Seq_TLL_Human1.26409263
81* EZH2_27294783_Chip-Seq_NPCs_Mouse1.25471691
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.25322485
83GBX2_23144817_ChIP-Seq_PC3_Human1.24886933
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22789817
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22727094
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22060836
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21692487
88* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21438591
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18848582
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.18772403
91* NFE2_27457419_Chip-Seq_LIVER_Mouse1.18474544
92TFEB_21752829_ChIP-Seq_HELA_Human1.17366168
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17169662
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15114696
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13856530
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13730350
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13385125
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12545949
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10880633
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10793072
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10547605
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10151314
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09160778
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09093949
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.07437535
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05847179
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05443145
108ER_23166858_ChIP-Seq_MCF-7_Human1.04984348
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03647304
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02506255
111SOX2_19829295_ChIP-Seq_ESCs_Human1.02161036
112NANOG_19829295_ChIP-Seq_ESCs_Human1.02161036
113* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01977985
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98794320
115MYC_18940864_ChIP-ChIP_HL60_Human0.98650245
116* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98254727
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98042810
118CBP_20019798_ChIP-Seq_JUKART_Human0.98042810
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97748377
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97653225
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95577696
122IRF1_19129219_ChIP-ChIP_H3396_Human0.95041658
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92914540
124* TP53_22573176_ChIP-Seq_HFKS_Human0.92859907
125* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92829186
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92813990
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91618587
128* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91506752
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91165239
130* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90571519
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89890008
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89867946
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89211977
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89105444
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89105444
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89105444
137* P300_18555785_Chip-Seq_ESCs_Mouse0.89069641
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89006213
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88999433
140* P53_22387025_ChIP-Seq_ESCs_Mouse0.88108481
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87432011
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.86082414
143SPI1_23547873_ChIP-Seq_NB4_Human0.85054931
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84656226
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83026512
146* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81789440
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80960038
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80815559
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.80647678
150* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79586181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.86990086
2MP0003111_abnormal_nucleus_morphology4.62044277
3MP0004957_abnormal_blastocyst_morpholog4.59449486
4MP0010094_abnormal_chromosome_stability4.49128720
5MP0003077_abnormal_cell_cycle4.03643854
6MP0008057_abnormal_DNA_replication3.95584943
7MP0008058_abnormal_DNA_repair3.67227544
8MP0008007_abnormal_cellular_replicative2.93802819
9MP0008932_abnormal_embryonic_tissue2.76544720
10MP0003123_paternal_imprinting2.69778172
11MP0002102_abnormal_ear_morphology2.45785394
12MP0001730_embryonic_growth_arrest2.37083984
13MP0002396_abnormal_hematopoietic_system2.31490163
14MP0003786_premature_aging2.29525930
15MP0000350_abnormal_cell_proliferation2.21239322
16MP0010352_gastrointestinal_tract_polyps2.14933972
17MP0000372_irregular_coat_pigmentation2.09165638
18MP0006072_abnormal_retinal_apoptosis2.06430861
19MP0008877_abnormal_DNA_methylation2.04404804
20MP0003806_abnormal_nucleotide_metabolis1.98719982
21MP0003718_maternal_effect1.93117629
22MP0002837_dystrophic_cardiac_calcinosis1.87885613
23MP0003646_muscle_fatigue1.81122045
24MP0001672_abnormal_embryogenesis/_devel1.80033838
25MP0005380_embryogenesis_phenotype1.80033838
26MP0003195_calcinosis1.79583807
27MP0001697_abnormal_embryo_size1.71622304
28MP0010030_abnormal_orbit_morphology1.66903323
29MP0000490_abnormal_crypts_of1.66569916
30MP0003984_embryonic_growth_retardation1.61055447
31MP0010307_abnormal_tumor_latency1.60757876
32MP0002080_prenatal_lethality1.59972873
33MP0002088_abnormal_embryonic_growth/wei1.56501694
34MP0002085_abnormal_embryonic_tissue1.48742439
35MP0002751_abnormal_autonomic_nervous1.48171288
36MP0002234_abnormal_pharynx_morphology1.47510572
37MP0003567_abnormal_fetal_cardiomyocyte1.46504097
38MP0000313_abnormal_cell_death1.45245862
39MP0006292_abnormal_olfactory_placode1.44922303
40MP0004197_abnormal_fetal_growth/weight/1.43117797
41MP0003787_abnormal_imprinting1.42172901
42MP0002019_abnormal_tumor_incidence1.40169991
43MP0009333_abnormal_splenocyte_physiolog1.38964544
44MP0002086_abnormal_extraembryonic_tissu1.37780022
45MP0002084_abnormal_developmental_patter1.34525990
46MP0001188_hyperpigmentation1.33382643
47MP0001293_anophthalmia1.32460782
48MP0001529_abnormal_vocalization1.31740819
49MP0005253_abnormal_eye_physiology1.30243989
50MP0003136_yellow_coat_color1.29090611
51MP0004215_abnormal_myocardial_fiber1.26067952
52MP0000631_abnormal_neuroendocrine_gland1.25920095
53MP0004808_abnormal_hematopoietic_stem1.25670553
54MP0003941_abnormal_skin_development1.25382166
55MP0001485_abnormal_pinna_reflex1.24352501
56MP0005551_abnormal_eye_electrophysiolog1.21939841
57MP0003315_abnormal_perineum_morphology1.21735978
58MP0002210_abnormal_sex_determination1.21063441
59MP0003186_abnormal_redox_activity1.16272824
60MP0003890_abnormal_embryonic-extraembry1.13225146
61MP0005397_hematopoietic_system_phenotyp1.12060845
62MP0001545_abnormal_hematopoietic_system1.12060845
63MP0002233_abnormal_nose_morphology1.10443786
64MP0001145_abnormal_male_reproductive1.09869410
65MP0002736_abnormal_nociception_after1.08818812
66MP0005187_abnormal_penis_morphology1.07755124
67MP0001984_abnormal_olfaction1.06630206
68MP0004145_abnormal_muscle_electrophysio1.06114713
69MP0003121_genomic_imprinting1.06056904
70MP0000647_abnormal_sebaceous_gland1.05379052
71MP0000358_abnormal_cell_content/1.04821291
72MP0005084_abnormal_gallbladder_morpholo1.04496673
73MP0008872_abnormal_physiological_respon1.02167028
74MP0003011_delayed_dark_adaptation1.01792466
75MP0002160_abnormal_reproductive_system1.00667852
76MP0000516_abnormal_urinary_system0.99396395
77MP0005367_renal/urinary_system_phenotyp0.99396395
78MP0004147_increased_porphyrin_level0.99327053
79MP0000703_abnormal_thymus_morphology0.97392116
80MP0003763_abnormal_thymus_physiology0.97353857
81MP0008789_abnormal_olfactory_epithelium0.96294140
82MP0003755_abnormal_palate_morphology0.95004228
83MP0004133_heterotaxia0.94667037
84MP0008775_abnormal_heart_ventricle0.92646874
85MP0000653_abnormal_sex_gland0.91849269
86MP0005646_abnormal_pituitary_gland0.90996986
87MP0002132_abnormal_respiratory_system0.90826493
88MP0003119_abnormal_digestive_system0.90620954
89MP0002722_abnormal_immune_system0.90224474
90MP0001929_abnormal_gametogenesis0.88769420
91MP0002090_abnormal_vision0.88156713
92MP0005389_reproductive_system_phenotype0.87510741
93MP0002111_abnormal_tail_morphology0.87133060
94MP0000689_abnormal_spleen_morphology0.87068875
95MP0000427_abnormal_hair_cycle0.86941456
96MP0002398_abnormal_bone_marrow0.86928337
97MP0000858_altered_metastatic_potential0.86827329
98MP0002638_abnormal_pupillary_reflex0.85592728
99MP0001119_abnormal_female_reproductive0.83647689
100MP0009250_abnormal_appendicular_skeleto0.83604789
101MP0003137_abnormal_impulse_conducting0.82195460
102MP0005384_cellular_phenotype0.79424439
103MP0003698_abnormal_male_reproductive0.79214586
104MP0008995_early_reproductive_senescence0.78618671
105MP0005391_vision/eye_phenotype0.77439498
106MP0002254_reproductive_system_inflammat0.76787004
107MP0005023_abnormal_wound_healing0.76341815
108MP0005408_hypopigmentation0.75784456
109MP0001853_heart_inflammation0.75759473
110MP0001324_abnormal_eye_pigmentation0.75594418
111MP0009046_muscle_twitch0.75582287
112MP0002163_abnormal_gland_morphology0.75211963
113MP0002282_abnormal_trachea_morphology0.75031182
114MP0005076_abnormal_cell_differentiation0.74856792
115MP0001968_abnormal_touch/_nociception0.74754662
116MP0009672_abnormal_birth_weight0.74745440
117MP0005075_abnormal_melanosome_morpholog0.74667400
118MP0006276_abnormal_autonomic_nervous0.74442113
119MP0000750_abnormal_muscle_regeneration0.74156336
120MP0005174_abnormal_tail_pigmentation0.73327606
121MP0005645_abnormal_hypothalamus_physiol0.72765053
122MP0002095_abnormal_skin_pigmentation0.72594296
123MP0003937_abnormal_limbs/digits/tail_de0.72178254
124MP0006035_abnormal_mitochondrial_morpho0.71440422
125MP0002429_abnormal_blood_cell0.71182459
126MP0006036_abnormal_mitochondrial_physio0.70742590
127MP0005621_abnormal_cell_physiology0.70465754
128MP0000537_abnormal_urethra_morphology0.70436485
129MP0003221_abnormal_cardiomyocyte_apopto0.70094797
130MP0001286_abnormal_eye_development0.69119285
131MP0006054_spinal_hemorrhage0.67837732
132MP0009053_abnormal_anal_canal0.67247325
133MP0009379_abnormal_foot_pigmentation0.67036076
134MP0002653_abnormal_ependyma_morphology0.65096039
135MP0001919_abnormal_reproductive_system0.63967827
136MP0002092_abnormal_eye_morphology0.63013823
137MP0000428_abnormal_craniofacial_morphol0.61844958
138MP0001915_intracranial_hemorrhage0.61593822
139MP0002938_white_spotting0.60712991
140MP0005266_abnormal_metabolism0.60694889
141MP0000477_abnormal_intestine_morphology0.60021666
142MP0000716_abnormal_immune_system0.55191695
143MP0003705_abnormal_hypodermis_morpholog0.54839339
144MP0009703_decreased_birth_body0.54426730
145MP0003936_abnormal_reproductive_system0.53628109
146MP0005395_other_phenotype0.53160035
147MP0000049_abnormal_middle_ear0.52924288
148MP0004264_abnormal_extraembryonic_tissu0.51732683
149MP0000432_abnormal_head_morphology0.51327826
150MP0001764_abnormal_homeostasis0.47394963
151MP0008260_abnormal_autophagy0.47028566
152MP0009697_abnormal_copulation0.46678934

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.43274708
2Abnormality of cells of the erythroid lineage (HP:0012130)4.83897086
3Abnormal number of erythroid precursors (HP:0012131)4.40534134
4Reticulocytopenia (HP:0001896)4.34771743
5Breast hypoplasia (HP:0003187)4.22245763
6Oral leukoplakia (HP:0002745)3.63866943
7Selective tooth agenesis (HP:0001592)3.50573890
8Carpal bone hypoplasia (HP:0001498)3.46276878
9Rough bone trabeculation (HP:0100670)3.43336195
10Patellar aplasia (HP:0006443)3.42043253
11Chromsome breakage (HP:0040012)3.40831822
12Acute necrotizing encephalopathy (HP:0006965)3.40376479
13Macrocytic anemia (HP:0001972)3.30848693
14Colon cancer (HP:0003003)3.27104716
15Aplasia/Hypoplasia of the patella (HP:0006498)3.26180560
16Cerebral hypomyelination (HP:0006808)3.18685747
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17847794
18Acute encephalopathy (HP:0006846)3.07529451
19Progressive macrocephaly (HP:0004481)3.04923163
20Degeneration of anterior horn cells (HP:0002398)3.04822776
21Abnormality of the anterior horn cell (HP:0006802)3.04822776
22Increased CSF lactate (HP:0002490)2.93485713
23Absent thumb (HP:0009777)2.92918926
24Pallor (HP:0000980)2.92689461
25Aplastic anemia (HP:0001915)2.91069382
26Methylmalonic acidemia (HP:0002912)2.89580666
27Increased hepatocellular lipid droplets (HP:0006565)2.89257916
28Abnormal mitochondria in muscle tissue (HP:0008316)2.88118131
29Trismus (HP:0000211)2.86944912
30Mitochondrial inheritance (HP:0001427)2.86789498
31Meckel diverticulum (HP:0002245)2.81231893
32Pancreatic cysts (HP:0001737)2.76504755
33Absent radius (HP:0003974)2.76490644
34Impulsivity (HP:0100710)2.73505023
35Abnormality of the preputium (HP:0100587)2.72648875
36Medulloblastoma (HP:0002885)2.69246272
37Pancreatic fibrosis (HP:0100732)2.68429868
38Microretrognathia (HP:0000308)2.68420994
39Volvulus (HP:0002580)2.67508326
40Abnormality of the ileum (HP:0001549)2.66878564
41Abnormality of chromosome stability (HP:0003220)2.66135897
42Microvesicular hepatic steatosis (HP:0001414)2.65905711
43Premature graying of hair (HP:0002216)2.65244182
44Lipid accumulation in hepatocytes (HP:0006561)2.64400146
45Agnosia (HP:0010524)2.61749115
46Ependymoma (HP:0002888)2.58184834
4711 pairs of ribs (HP:0000878)2.57912009
48Aplasia involving forearm bones (HP:0009822)2.56353643
49Absent forearm bone (HP:0003953)2.56353643
50Abnormal trabecular bone morphology (HP:0100671)2.53892574
51Multiple enchondromatosis (HP:0005701)2.52704501
52Neoplasm of the pancreas (HP:0002894)2.49031744
53True hermaphroditism (HP:0010459)2.48923938
54Horseshoe kidney (HP:0000085)2.45850006
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45611675
56Hepatocellular necrosis (HP:0001404)2.43871361
57Myelodysplasia (HP:0002863)2.42313220
58Abnormality of methionine metabolism (HP:0010901)2.37615177
59Abnormal number of incisors (HP:0011064)2.37379844
60Congenital, generalized hypertrichosis (HP:0004540)2.36279201
61Supernumerary spleens (HP:0009799)2.34728181
62Hyperglycinemia (HP:0002154)2.33935183
63Abnormality of serum amino acid levels (HP:0003112)2.30534168
64Premature ovarian failure (HP:0008209)2.30485047
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.30364374
66Abnormality of midbrain morphology (HP:0002418)2.29774046
67Molar tooth sign on MRI (HP:0002419)2.29774046
68Methylmalonic aciduria (HP:0012120)2.28436562
69Progressive muscle weakness (HP:0003323)2.28008318
70Cerebral edema (HP:0002181)2.27889651
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26677627
72Atresia of the external auditory canal (HP:0000413)2.25723326
73Bone marrow hypocellularity (HP:0005528)2.25522965
74Cleft eyelid (HP:0000625)2.24538873
75Muscle fiber atrophy (HP:0100295)2.24491354
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23841812
77Abnormality of alanine metabolism (HP:0010916)2.23841812
78Hyperalaninemia (HP:0003348)2.23841812
79Small intestinal stenosis (HP:0012848)2.23585466
80Duodenal stenosis (HP:0100867)2.23585466
81Hepatic necrosis (HP:0002605)2.22730943
82Abnormality of the labia minora (HP:0012880)2.22236781
83Abnormal lung lobation (HP:0002101)2.21519186
84Secondary amenorrhea (HP:0000869)2.19417219
85Type 2 muscle fiber atrophy (HP:0003554)2.19118601
86Cellular immunodeficiency (HP:0005374)2.18500483
87Rhabdomyosarcoma (HP:0002859)2.16938164
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15402025
89Neoplasm of the adrenal cortex (HP:0100641)2.13889804
90Irregular epiphyses (HP:0010582)2.12476774
91Glossoptosis (HP:0000162)2.11641263
92Pendular nystagmus (HP:0012043)2.10530961
93Nephronophthisis (HP:0000090)2.10360591
94Megaloblastic anemia (HP:0001889)2.09277078
95Neoplasm of the adrenal gland (HP:0100631)2.09070700
96Tracheoesophageal fistula (HP:0002575)2.08364153
97Type I transferrin isoform profile (HP:0003642)2.08100664
98Intestinal atresia (HP:0011100)2.07757511
99Triphalangeal thumb (HP:0001199)2.07171922
100Hypoplasia of the radius (HP:0002984)2.05618050
101Sloping forehead (HP:0000340)2.05449083
102Glioma (HP:0009733)2.04871191
103Facial cleft (HP:0002006)2.03328683
104Sparse eyelashes (HP:0000653)2.03259479
105Stenosis of the external auditory canal (HP:0000402)2.02331665
106Thrombocytosis (HP:0001894)2.00354033
107Abolished electroretinogram (ERG) (HP:0000550)1.99131114
108Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98151248
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98151248
110Basal cell carcinoma (HP:0002671)1.97063615
111Pancytopenia (HP:0001876)1.97029371
112Squamous cell carcinoma (HP:0002860)1.96731743
113Slender long bone (HP:0003100)1.96045374
114Renal Fanconi syndrome (HP:0001994)1.93294847
115Ureteral duplication (HP:0000073)1.93174593
116Optic disc pallor (HP:0000543)1.91294157
117Abnormality of the duodenum (HP:0002246)1.91273612
118Ectopic kidney (HP:0000086)1.91114580
119Pancreatic islet-cell hyperplasia (HP:0004510)1.90912512
1203-Methylglutaconic aciduria (HP:0003535)1.87929671
121Clubbing of toes (HP:0100760)1.87479995
122Leukodystrophy (HP:0002415)1.87045629
123Abnormality of the umbilical cord (HP:0010881)1.85396165
124Increased serum lactate (HP:0002151)1.85315434
125Short thumb (HP:0009778)1.84491582
126Lactic acidosis (HP:0003128)1.84072837
127Abnormality of pyrimidine metabolism (HP:0004353)1.83902554
128Congenital stationary night blindness (HP:0007642)1.83737659
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.83727121
130Missing ribs (HP:0000921)1.83319636
131Duplicated collecting system (HP:0000081)1.81015145
132Lymphoma (HP:0002665)1.80438130
133Abnormal spermatogenesis (HP:0008669)1.79123870
134Astrocytoma (HP:0009592)1.78609885
135Abnormality of the astrocytes (HP:0100707)1.78609885
136Abnormality of the renal cortex (HP:0011035)1.78388322
137Proximal placement of thumb (HP:0009623)1.77747768
138Progressive inability to walk (HP:0002505)1.77439084
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77342967
140Aplasia/hypoplasia of the humerus (HP:0006507)1.77255898
141CNS hypomyelination (HP:0003429)1.76425881
142Abnormality of vitamin B metabolism (HP:0004340)1.76011095
143Respiratory failure (HP:0002878)1.75408121
144Small hand (HP:0200055)1.75244252
145Deviation of the thumb (HP:0009603)1.74861704
146Renal cortical cysts (HP:0000803)1.74682475
147Embryonal renal neoplasm (HP:0011794)1.74589711
148Sclerocornea (HP:0000647)1.74234852
149Nephroblastoma (Wilms tumor) (HP:0002667)1.74204233
150Abnormality of the renal medulla (HP:0100957)1.74097926
151Abnormality of the carotid arteries (HP:0005344)1.74046925
152Abnormality of serine family amino acid metabolism (HP:0010894)1.73918001
153Abnormality of glycine metabolism (HP:0010895)1.73918001
154Meningioma (HP:0002858)1.72582255
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.71152724
156Spinal muscular atrophy (HP:0007269)1.71015871
157Hypothermia (HP:0002045)1.70762956
158Neoplasm of the colon (HP:0100273)1.70236922
159Bilateral microphthalmos (HP:0007633)1.69966180
160Amaurosis fugax (HP:0100576)1.68967234
161Poor head control (HP:0002421)1.68653055
162Gastrointestinal atresia (HP:0002589)1.68606170
163Hyperglycinuria (HP:0003108)1.66369862
164Medial flaring of the eyebrow (HP:0010747)1.66024717
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.65924586
166Septo-optic dysplasia (HP:0100842)1.65669838
167Homocystinuria (HP:0002156)1.65403035
168Abnormality of homocysteine metabolism (HP:0010919)1.65403035
169Lethargy (HP:0001254)1.65058696
170Abnormality of the pons (HP:0007361)1.63536127
171Exertional dyspnea (HP:0002875)1.61558480
172Dandy-Walker malformation (HP:0001305)1.60504427
173Increased serum pyruvate (HP:0003542)1.59438304
174Hypoplastic pelvis (HP:0008839)1.58994258
175Male pseudohermaphroditism (HP:0000037)1.58573958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.96041849
2WEE14.13807959
3EIF2AK13.77337623
4CDC73.53387681
5FRK2.98633095
6SRPK12.83177941
7TRIM282.82861217
8NUAK12.79990664
9NME22.72221247
10WNK32.69878154
11PLK42.59730387
12EIF2AK32.49998504
13TSSK62.47973812
14NEK22.39745448
15STK162.37654847
16VRK22.28608006
17TTK2.22700349
18TNIK2.15291458
19BMPR1B2.12108352
20PLK11.98453560
21ACVR1B1.97186689
22MKNK11.94924446
23BRSK21.92162528
24VRK11.85952305
25DYRK31.84727013
26TESK21.82174080
27RPS6KB21.79385100
28MKNK21.79318826
29CDK71.76404452
30ERBB31.73509150
31NEK11.69812477
32EPHA21.68137856
33TAF11.63993986
34PLK31.63006844
35AURKB1.60559564
36TLK11.56291318
37ZAK1.55071822
38RPS6KA41.54515015
39ATR1.54445583
40PASK1.46400127
41MAP4K21.44791992
42PLK21.35850754
43BCR1.34278169
44GRK11.34138772
45CHEK21.32331493
46AURKA1.31804795
47MAP3K81.29667252
48PIM21.26671285
49BRSK11.21204034
50CDK121.19525949
51ADRBK21.18790317
52CHEK11.14797667
53CDK41.14395810
54SCYL21.10875160
55STK101.06353301
56CASK1.05980959
57STK391.05190444
58OXSR11.03752416
59KDR1.01735745
60TGFBR11.01519680
61CSNK1G10.98902069
62INSRR0.97548578
63PAK40.95644218
64CCNB10.95082511
65MAP3K40.92666426
66EIF2AK20.91299067
67TAOK20.90657070
68PIM10.87715268
69IRAK30.80387197
70CSNK1G20.79355824
71ATM0.79127571
72CSNK2A20.78834855
73ALK0.78668336
74FGFR20.78570832
75STK38L0.78087787
76CDK20.77478626
77CSNK1G30.73896857
78STK40.73473835
79MAPKAPK30.73256842
80MAP3K110.73134395
81PINK10.73079813
82CSNK2A10.71975179
83OBSCN0.71938760
84CDK80.70699568
85TESK10.70657557
86EEF2K0.69853777
87PAK10.68772638
88PRKCI0.65635266
89WNK40.63224262
90NME10.62956096
91TRPM70.62665043
92MAP2K30.61749672
93PAK30.61683461
94BRAF0.60222384
95STK30.59464851
96CSNK1A1L0.55789715
97PRKCG0.55073763
98RPS6KA50.54629641
99FLT30.54216750
100MELK0.52872151
101CDK10.52753183
102PNCK0.52749432
103PHKG10.52345098
104PHKG20.52345098
105BCKDK0.49628104
106MAP3K30.49590160
107MAPKAPK50.49403586
108CDK30.48620078
109SIK30.48434364
110MAPK130.48253653
111BRD40.47242148
112LATS20.47138701
113PRKCE0.46357140
114MUSK0.46197210
115LRRK20.45723267
116AKT30.43947766
117NLK0.43871458
118PBK0.42057563
119FGFR10.42029930
120CDK60.41401679
121MAP4K10.40432759
122CSNK1E0.38715807
123MINK10.38436399
124ILK0.36541992
125STK240.36489089
126DYRK20.35346479
127ABL20.34379113
128ERBB40.34230384
129MST40.33879205
130AKT20.33555309
131MAP2K70.33443438
132LATS10.32340463
133CSNK1A10.31097490
134ADRBK10.30663727
135IKBKB0.29433325
136DMPK0.28551119
137PRKDC0.28115233
138TEC0.26787953
139PAK20.26487930
140MTOR0.26361591
141IRAK40.25817775
142ZAP700.25238114
143MARK30.25150803
144MAP3K50.20901060
145LIMK10.19596045
146MAPKAPK20.18875858
147PDK20.17868852

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62431646
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.17442423
3Mismatch repair_Homo sapiens_hsa034304.01224080
4Ribosome_Homo sapiens_hsa030103.95781299
5RNA polymerase_Homo sapiens_hsa030203.81147623
6Proteasome_Homo sapiens_hsa030503.69310140
7Spliceosome_Homo sapiens_hsa030403.35436888
8RNA transport_Homo sapiens_hsa030133.20158222
9Homologous recombination_Homo sapiens_hsa034402.86684120
10Base excision repair_Homo sapiens_hsa034102.80709720
11Nucleotide excision repair_Homo sapiens_hsa034202.77128913
12Pyrimidine metabolism_Homo sapiens_hsa002402.67292938
13One carbon pool by folate_Homo sapiens_hsa006702.59392726
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51324817
15Cell cycle_Homo sapiens_hsa041102.45929295
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06470185
17Fanconi anemia pathway_Homo sapiens_hsa034602.05586694
18Basal transcription factors_Homo sapiens_hsa030221.99521362
19Non-homologous end-joining_Homo sapiens_hsa034501.93844593
20RNA degradation_Homo sapiens_hsa030181.91903075
21Propanoate metabolism_Homo sapiens_hsa006401.85105818
22mRNA surveillance pathway_Homo sapiens_hsa030151.54687442
23p53 signaling pathway_Homo sapiens_hsa041151.51463889
24Purine metabolism_Homo sapiens_hsa002301.45544179
25Steroid biosynthesis_Homo sapiens_hsa001001.44182706
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40774672
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38085566
28Alzheimers disease_Homo sapiens_hsa050101.31847659
29Vitamin B6 metabolism_Homo sapiens_hsa007501.28791513
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21483890
31Butanoate metabolism_Homo sapiens_hsa006501.21277666
32Pyruvate metabolism_Homo sapiens_hsa006201.19746838
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15390155
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.11664253
35Folate biosynthesis_Homo sapiens_hsa007901.11233913
36Fatty acid elongation_Homo sapiens_hsa000621.01912922
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.00514398
38Phototransduction_Homo sapiens_hsa047440.97543251
39Systemic lupus erythematosus_Homo sapiens_hsa053220.96460071
40Sulfur metabolism_Homo sapiens_hsa009200.93244801
41Sulfur relay system_Homo sapiens_hsa041220.93008561
42Protein export_Homo sapiens_hsa030600.91175283
43Biosynthesis of amino acids_Homo sapiens_hsa012300.88540466
44Selenocompound metabolism_Homo sapiens_hsa004500.88383611
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.87675877
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86888953
47Pentose phosphate pathway_Homo sapiens_hsa000300.86784246
48Antigen processing and presentation_Homo sapiens_hsa046120.86622345
49Herpes simplex infection_Homo sapiens_hsa051680.85911729
50Nitrogen metabolism_Homo sapiens_hsa009100.84705885
51Tryptophan metabolism_Homo sapiens_hsa003800.83939410
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81505561
53Peroxisome_Homo sapiens_hsa041460.78155538
54Cardiac muscle contraction_Homo sapiens_hsa042600.76184077
55Viral carcinogenesis_Homo sapiens_hsa052030.76128686
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68426287
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68256226
58Oocyte meiosis_Homo sapiens_hsa041140.67959085
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63044297
60Huntingtons disease_Homo sapiens_hsa050160.61773792
61HTLV-I infection_Homo sapiens_hsa051660.61584963
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61444659
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61139493
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.60034232
65Glutathione metabolism_Homo sapiens_hsa004800.59945146
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57931041
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57168438
68beta-Alanine metabolism_Homo sapiens_hsa004100.56898216
69Thyroid cancer_Homo sapiens_hsa052160.55429608
70Caffeine metabolism_Homo sapiens_hsa002320.54790316
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53324038
72Retinol metabolism_Homo sapiens_hsa008300.53134176
73Vitamin digestion and absorption_Homo sapiens_hsa049770.52754972
74Legionellosis_Homo sapiens_hsa051340.50033568
75Fructose and mannose metabolism_Homo sapiens_hsa000510.49762311
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48861633
77Nicotine addiction_Homo sapiens_hsa050330.48460151
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46592082
79Carbon metabolism_Homo sapiens_hsa012000.45031586
80Fatty acid degradation_Homo sapiens_hsa000710.44990173
81Linoleic acid metabolism_Homo sapiens_hsa005910.43941763
82Small cell lung cancer_Homo sapiens_hsa052220.43328829
83Fatty acid metabolism_Homo sapiens_hsa012120.43063176
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42817397
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41075781
86Parkinsons disease_Homo sapiens_hsa050120.40082099
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39995617
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39363433
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38445503
90Primary immunodeficiency_Homo sapiens_hsa053400.37915516
91Apoptosis_Homo sapiens_hsa042100.37878606
92Chemical carcinogenesis_Homo sapiens_hsa052040.36995075
93Taste transduction_Homo sapiens_hsa047420.36957395
94MicroRNAs in cancer_Homo sapiens_hsa052060.35929574
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35831462
96Ether lipid metabolism_Homo sapiens_hsa005650.34605914
97Galactose metabolism_Homo sapiens_hsa000520.34543819
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33200303
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32435363
100Wnt signaling pathway_Homo sapiens_hsa043100.31212354
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31062853
102TGF-beta signaling pathway_Homo sapiens_hsa043500.30951749
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.30839856
104Metabolic pathways_Homo sapiens_hsa011000.30282749
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30127536
106Shigellosis_Homo sapiens_hsa051310.28841991
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28094095
108Measles_Homo sapiens_hsa051620.27986701
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.27856026
110N-Glycan biosynthesis_Homo sapiens_hsa005100.27482451
111Olfactory transduction_Homo sapiens_hsa047400.27372875
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27364067
113Hippo signaling pathway_Homo sapiens_hsa043900.27345627
114Collecting duct acid secretion_Homo sapiens_hsa049660.26691911
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.26602539
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24792986
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24611260
118Basal cell carcinoma_Homo sapiens_hsa052170.22360003
119Arginine and proline metabolism_Homo sapiens_hsa003300.21916135
120Hepatitis B_Homo sapiens_hsa051610.20546669
121Oxidative phosphorylation_Homo sapiens_hsa001900.19093069
122Alcoholism_Homo sapiens_hsa050340.18870544
123Regulation of autophagy_Homo sapiens_hsa041400.18785809
124Bladder cancer_Homo sapiens_hsa052190.18373245
125Acute myeloid leukemia_Homo sapiens_hsa052210.17864992
126HIF-1 signaling pathway_Homo sapiens_hsa040660.17469289
127Arachidonic acid metabolism_Homo sapiens_hsa005900.16031424
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15672739
129Colorectal cancer_Homo sapiens_hsa052100.15597948
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15126638
131Influenza A_Homo sapiens_hsa051640.14471835
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12334146
133Pathways in cancer_Homo sapiens_hsa052000.12128244
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11890104
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11154561
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.09451225
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08940592
138Hedgehog signaling pathway_Homo sapiens_hsa043400.07924216
139Notch signaling pathway_Homo sapiens_hsa043300.07827853
140Hematopoietic cell lineage_Homo sapiens_hsa046400.06959381
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.06766255
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06638108

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