RRP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.79995770
2nuclear pore complex assembly (GO:0051292)4.65987220
3IMP biosynthetic process (GO:0006188)4.55907504
4protein localization to kinetochore (GO:0034501)4.53977478
5DNA replication initiation (GO:0006270)4.47683357
6nucleobase biosynthetic process (GO:0046112)4.46682723
7DNA unwinding involved in DNA replication (GO:0006268)4.46156576
8DNA strand elongation involved in DNA replication (GO:0006271)4.33320536
9maturation of SSU-rRNA (GO:0030490)4.26363076
10regulation of translational fidelity (GO:0006450)4.24652884
11protein complex localization (GO:0031503)4.23385674
12mitotic nuclear envelope disassembly (GO:0007077)4.14781869
13DNA strand elongation (GO:0022616)4.13638743
14mitotic metaphase plate congression (GO:0007080)4.06444846
15telomere maintenance via semi-conservative replication (GO:0032201)3.98951964
16purine nucleobase biosynthetic process (GO:0009113)3.98725251
17folic acid-containing compound biosynthetic process (GO:0009396)3.95791296
18ribosome biogenesis (GO:0042254)3.95220459
19cellular protein complex localization (GO:0034629)3.94449435
20DNA replication-dependent nucleosome organization (GO:0034723)3.89513693
21DNA replication-dependent nucleosome assembly (GO:0006335)3.89513693
22IMP metabolic process (GO:0046040)3.89479550
23formation of translation preinitiation complex (GO:0001731)3.85903821
24DNA replication checkpoint (GO:0000076)3.84718790
25ribosome assembly (GO:0042255)3.84511118
26heterochromatin organization (GO:0070828)3.81803869
27nuclear envelope disassembly (GO:0051081)3.80782111
28membrane disassembly (GO:0030397)3.80782111
29DNA topological change (GO:0006265)3.79526948
30ribosomal small subunit assembly (GO:0000028)3.78532707
31protein localization to chromosome, centromeric region (GO:0071459)3.72290213
32kinetochore organization (GO:0051383)3.68082404
33ribonucleoprotein complex biogenesis (GO:0022613)3.67174142
34negative regulation of mRNA processing (GO:0050686)3.66956171
35telomere maintenance via recombination (GO:0000722)3.64210716
36chromatin remodeling at centromere (GO:0031055)3.60964936
37pore complex assembly (GO:0046931)3.60941274
38CENP-A containing nucleosome assembly (GO:0034080)3.57623091
39metaphase plate congression (GO:0051310)3.57513225
40mitotic recombination (GO:0006312)3.56123430
41DNA duplex unwinding (GO:0032508)3.55917407
42DNA geometric change (GO:0032392)3.55186280
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52253417
44regulation of translational termination (GO:0006449)3.51654565
45negative regulation of mRNA metabolic process (GO:1903312)3.48736977
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.48476679
47ribosomal large subunit biogenesis (GO:0042273)3.47947249
48telomere maintenance via telomere lengthening (GO:0010833)3.44807572
49non-recombinational repair (GO:0000726)3.43540365
50double-strand break repair via nonhomologous end joining (GO:0006303)3.43540365
51DNA replication-independent nucleosome organization (GO:0034724)3.41308997
52DNA replication-independent nucleosome assembly (GO:0006336)3.41308997
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.39981949
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39981949
55regulation of posttranscriptional gene silencing (GO:0060147)3.37656528
56regulation of gene silencing by miRNA (GO:0060964)3.37656528
57regulation of gene silencing by RNA (GO:0060966)3.37656528
58pre-miRNA processing (GO:0031054)3.36314682
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.35991438
60* rRNA processing (GO:0006364)3.34632597
61mitotic sister chromatid segregation (GO:0000070)3.34110087
62kinetochore assembly (GO:0051382)3.33110560
63mitotic chromosome condensation (GO:0007076)3.31949793
64spliceosomal snRNP assembly (GO:0000387)3.28986428
65ribosomal small subunit biogenesis (GO:0042274)3.28246528
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.26966325
67regulation of spindle organization (GO:0090224)3.25805656
68pseudouridine synthesis (GO:0001522)3.25082104
69* rRNA metabolic process (GO:0016072)3.24642329
70L-serine metabolic process (GO:0006563)3.20976982
71attachment of spindle microtubules to kinetochore (GO:0008608)3.20970645
72termination of RNA polymerase II transcription (GO:0006369)3.20290432
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18420314
74chromosome condensation (GO:0030261)3.17699957
75establishment of chromosome localization (GO:0051303)3.17148696
76regulation of chromosome segregation (GO:0051983)3.14538168
77rRNA transcription (GO:0009303)3.14129332
78regulation of RNA export from nucleus (GO:0046831)3.10805221
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10572080
80regulation of sister chromatid cohesion (GO:0007063)3.08996242
81sister chromatid segregation (GO:0000819)3.08846093
82translational termination (GO:0006415)3.08218198
83viral transcription (GO:0019083)3.07781363
84histone exchange (GO:0043486)3.07716098
85regulation of helicase activity (GO:0051095)3.06568380
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.06404454
87negative regulation of sister chromatid segregation (GO:0033046)3.06404454
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06404454
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06404454
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06404454
91mismatch repair (GO:0006298)3.06374592
92mRNA transport (GO:0051028)3.05061524
93ATP-dependent chromatin remodeling (GO:0043044)3.04963779
94rRNA modification (GO:0000154)3.03013554
95positive regulation of chromosome segregation (GO:0051984)3.02829844
96RNA splicing, via transesterification reactions (GO:0000375)3.02760911
97maturation of 5.8S rRNA (GO:0000460)3.02432550
98mitotic spindle checkpoint (GO:0071174)3.02419170
99tRNA aminoacylation for protein translation (GO:0006418)3.02262023
100transcription from mitochondrial promoter (GO:0006390)3.02003112
101meiotic chromosome segregation (GO:0045132)3.01319637
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00092174
103mRNA splicing, via spliceosome (GO:0000398)3.00092174
104translational initiation (GO:0006413)2.99813810
105V(D)J recombination (GO:0033151)2.99806479
106chromatin assembly (GO:0031497)2.99796635
107chromatin assembly or disassembly (GO:0006333)2.98315464
108amino acid activation (GO:0043038)2.97904402
109tRNA aminoacylation (GO:0043039)2.97904402
110establishment of integrated proviral latency (GO:0075713)2.97689932
111mitotic sister chromatid cohesion (GO:0007064)2.96633297
112regulation of histone H3-K9 methylation (GO:0051570)2.96003753
113spliceosomal complex assembly (GO:0000245)2.95692493
114DNA synthesis involved in DNA repair (GO:0000731)2.95004269
115DNA conformation change (GO:0071103)2.93895458
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93688129
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93688129
118establishment of viral latency (GO:0019043)2.93407225
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93015063
120mitotic spindle assembly checkpoint (GO:0007094)2.92638160
121regulation of mitotic spindle organization (GO:0060236)2.92244125
122negative regulation of histone methylation (GO:0031061)2.91965968
123DNA ligation (GO:0006266)2.91371227
124mitochondrial RNA metabolic process (GO:0000959)2.90316291
125regulation of centrosome cycle (GO:0046605)2.90268680
126transcription-coupled nucleotide-excision repair (GO:0006283)2.89195753
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.87995835
128protein K6-linked ubiquitination (GO:0085020)2.87634159
129viral mRNA export from host cell nucleus (GO:0046784)2.87273867
130telomere maintenance (GO:0000723)2.86971673
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86220552
132telomere organization (GO:0032200)2.85934158
133nuclear envelope organization (GO:0006998)2.85459771
134translational elongation (GO:0006414)2.84272877
135negative regulation of RNA splicing (GO:0033119)2.84238341
136histone arginine methylation (GO:0034969)2.83112092
137negative regulation of chromosome segregation (GO:0051985)2.83047948
138peptidyl-arginine omega-N-methylation (GO:0035247)2.82877193
139spindle checkpoint (GO:0031577)2.82073216
140transcription elongation from RNA polymerase I promoter (GO:0006362)2.81939033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.53479118
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45233557
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11835417
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95423881
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23516095
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22644020
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17484054
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95525601
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.76210957
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76112135
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76024640
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.51773552
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47802860
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35870775
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35358475
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.35057269
17XRN2_22483619_ChIP-Seq_HELA_Human2.26014950
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24460715
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23713191
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18527941
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13808114
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.09170034
23VDR_23849224_ChIP-Seq_CD4+_Human2.04565690
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.02908485
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02068280
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94281079
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93540309
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92696001
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91839110
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91059286
31AR_21909140_ChIP-Seq_LNCAP_Human1.91040473
32MYC_22102868_ChIP-Seq_BL_Human1.87303012
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85164224
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84498782
35TTF2_22483619_ChIP-Seq_HELA_Human1.81577290
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78245191
37CIITA_25753668_ChIP-Seq_RAJI_Human1.77366018
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74638802
39DCP1A_22483619_ChIP-Seq_HELA_Human1.73531984
40GABP_19822575_ChIP-Seq_HepG2_Human1.68683738
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66501955
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.66039307
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62858044
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58191301
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57581349
46ELK1_19687146_ChIP-ChIP_HELA_Human1.55284851
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55121773
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53758543
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52744302
50KDM5A_27292631_Chip-Seq_BREAST_Human1.49554105
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.48705559
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48548190
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.47279244
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44532038
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42050372
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41864400
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41188794
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.39706424
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38877477
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37049214
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37049214
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37049214
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35384135
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29425444
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28689395
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28091225
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20710393
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17639498
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16651332
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15771893
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13731813
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12752083
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12134986
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09383534
75TFEB_21752829_ChIP-Seq_HELA_Human1.08955944
76* SRF_21415370_ChIP-Seq_HL-1_Mouse1.08800454
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08620745
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07858013
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06229610
80CHD1_26751641_Chip-Seq_LNCaP_Human1.06071123
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05650617
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05293740
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03990182
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02007200
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.00084857
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00074494
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99463042
88MYC_18940864_ChIP-ChIP_HL60_Human0.98298815
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97370899
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96995057
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95477819
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94423565
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94070559
94TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93497705
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93192852
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92925044
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92062103
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91690519
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90915363
100ZNF263_19887448_ChIP-Seq_K562_Human0.90150623
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89171728
102VDR_21846776_ChIP-Seq_THP-1_Human0.88958401
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88904423
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88043365
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87819827
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.87129306
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86446299
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86105050
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84732082
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84718573
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84547575
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83220393
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74405628
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72661293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.02162764
2MP0010094_abnormal_chromosome_stability4.78224766
3MP0003111_abnormal_nucleus_morphology4.42802007
4MP0008057_abnormal_DNA_replication4.22344630
5MP0004957_abnormal_blastocyst_morpholog4.19960418
6MP0003077_abnormal_cell_cycle3.88820442
7MP0008058_abnormal_DNA_repair3.56845165
8MP0008007_abnormal_cellular_replicative2.72261947
9MP0003123_paternal_imprinting2.61355774
10MP0008932_abnormal_embryonic_tissue2.52513226
11MP0002396_abnormal_hematopoietic_system2.40474192
12MP0002877_abnormal_melanocyte_morpholog2.36925292
13MP0010352_gastrointestinal_tract_polyps2.35619413
14MP0000350_abnormal_cell_proliferation2.32013443
15MP0001730_embryonic_growth_arrest2.31975290
16MP0008877_abnormal_DNA_methylation2.10988175
17MP0003786_premature_aging1.98596050
18MP0005380_embryogenesis_phenotype1.93809200
19MP0001672_abnormal_embryogenesis/_devel1.93809200
20MP0003890_abnormal_embryonic-extraembry1.86854143
21MP0001697_abnormal_embryo_size1.79638904
22MP0000537_abnormal_urethra_morphology1.79079914
23MP0003121_genomic_imprinting1.78898689
24MP0010307_abnormal_tumor_latency1.78068270
25MP0002009_preneoplasia1.76625069
26MP0002085_abnormal_embryonic_tissue1.74390970
27MP0010030_abnormal_orbit_morphology1.74347489
28MP0003984_embryonic_growth_retardation1.72808307
29MP0003705_abnormal_hypodermis_morpholog1.70830299
30MP0002088_abnormal_embryonic_growth/wei1.69695154
31MP0002084_abnormal_developmental_patter1.68869393
32MP0006292_abnormal_olfactory_placode1.66934434
33MP0004197_abnormal_fetal_growth/weight/1.62885046
34MP0009697_abnormal_copulation1.60627253
35MP0004233_abnormal_muscle_weight1.60616477
36MP0002080_prenatal_lethality1.58689825
37MP0000490_abnormal_crypts_of1.58267089
38MP0002086_abnormal_extraembryonic_tissu1.51423268
39MP0004185_abnormal_adipocyte_glucose1.51063595
40MP0001293_anophthalmia1.50292159
41MP0004808_abnormal_hematopoietic_stem1.48272027
42MP0000313_abnormal_cell_death1.45400591
43MP0003763_abnormal_thymus_physiology1.42008488
44MP0003718_maternal_effect1.32268109
45MP0004133_heterotaxia1.30962211
46MP0005076_abnormal_cell_differentiation1.30406987
47MP0002019_abnormal_tumor_incidence1.30093397
48MP0002796_impaired_skin_barrier1.27146242
49MP0003941_abnormal_skin_development1.25150771
50MP0000703_abnormal_thymus_morphology1.19770171
51MP0005501_abnormal_skin_physiology1.17906856
52MP0003567_abnormal_fetal_cardiomyocyte1.17757093
53MP0003119_abnormal_digestive_system1.15262890
54MP0010234_abnormal_vibrissa_follicle1.12886996
55MP0009333_abnormal_splenocyte_physiolog1.12786920
56MP0001661_extended_life_span1.12344598
57MP0002210_abnormal_sex_determination1.10995568
58MP0001346_abnormal_lacrimal_gland1.08644500
59MP0002653_abnormal_ependyma_morphology1.07659807
60MP0006035_abnormal_mitochondrial_morpho1.06903600
61MP0003221_abnormal_cardiomyocyte_apopto1.04070951
62MP0001145_abnormal_male_reproductive0.98524251
63MP0002398_abnormal_bone_marrow0.97321786
64MP0002111_abnormal_tail_morphology0.96696001
65MP0005623_abnormal_meninges_morphology0.96054965
66MP0002722_abnormal_immune_system0.93913069
67MP0003937_abnormal_limbs/digits/tail_de0.91795468
68MP0003315_abnormal_perineum_morphology0.90056424
69MP0001286_abnormal_eye_development0.89389035
70MP0000689_abnormal_spleen_morphology0.87455760
71MP0003385_abnormal_body_wall0.85490940
72MP0001545_abnormal_hematopoietic_system0.83779570
73MP0005397_hematopoietic_system_phenotyp0.83779570
74MP0000653_abnormal_sex_gland0.83294055
75MP0000566_synostosis0.82870060
76MP0005451_abnormal_body_composition0.82358900
77MP0003806_abnormal_nucleotide_metabolis0.82257550
78MP0002160_abnormal_reproductive_system0.81563361
79MP0009672_abnormal_birth_weight0.81468998
80MP0001929_abnormal_gametogenesis0.81468404
81MP0009703_decreased_birth_body0.81420483
82MP0000428_abnormal_craniofacial_morphol0.81006070
83MP0001119_abnormal_female_reproductive0.78691504
84MP0005384_cellular_phenotype0.78475907
85MP0001849_ear_inflammation0.77256955
86MP0006072_abnormal_retinal_apoptosis0.76980967
87MP0000678_abnormal_parathyroid_gland0.76659398
88MP0002006_tumorigenesis0.75434234
89MP0002938_white_spotting0.74397156
90MP0000432_abnormal_head_morphology0.74093526
91MP0000627_abnormal_mammary_gland0.72853519
92MP0002166_altered_tumor_susceptibility0.72085955
93MP0001915_intracranial_hemorrhage0.71626704
94MP0001881_abnormal_mammary_gland0.71450352
95MP0003787_abnormal_imprinting0.71118861
96MP0005621_abnormal_cell_physiology0.70727849
97MP0002429_abnormal_blood_cell0.70447839
98MP0000358_abnormal_cell_content/0.70092886
99MP0000579_abnormal_nail_morphology0.70050115
100MP0009053_abnormal_anal_canal0.69508143
101MP0003115_abnormal_respiratory_system0.68835764
102MP0003942_abnormal_urinary_system0.68730382
103MP0008260_abnormal_autophagy0.68682836
104MP0005389_reproductive_system_phenotype0.67569786
105MP0002092_abnormal_eye_morphology0.67409104
106MP0000049_abnormal_middle_ear0.66307953
107MP0005023_abnormal_wound_healing0.66283490
108MP0001727_abnormal_embryo_implantation0.66235254
109MP0005391_vision/eye_phenotype0.65680434
110MP0002233_abnormal_nose_morphology0.65091848
111MP0000516_abnormal_urinary_system0.64493618
112MP0005367_renal/urinary_system_phenotyp0.64493618
113MP0008789_abnormal_olfactory_epithelium0.64381283
114MP0003453_abnormal_keratinocyte_physiol0.62090215
115MP0003935_abnormal_craniofacial_develop0.61010795
116MP0003861_abnormal_nervous_system0.61005384
117MP0004264_abnormal_extraembryonic_tissu0.60741172
118MP0000858_altered_metastatic_potential0.60513957
119MP0001216_abnormal_epidermal_layer0.60208383
120MP0000733_abnormal_muscle_development0.60092179
121MP0000477_abnormal_intestine_morphology0.59604848
122MP0002697_abnormal_eye_size0.59550712
123MP0002925_abnormal_cardiovascular_devel0.59100271
124MP0000762_abnormal_tongue_morphology0.59060002
125MP0002249_abnormal_larynx_morphology0.58927094
126MP0003936_abnormal_reproductive_system0.58864676
127MP0002114_abnormal_axial_skeleton0.58857330
128MP0000716_abnormal_immune_system0.58255751
129MP0002075_abnormal_coat/hair_pigmentati0.58201243
130MP0002132_abnormal_respiratory_system0.57613349
131MP0005394_taste/olfaction_phenotype0.56843322
132MP0005499_abnormal_olfactory_system0.56843322
133MP0003943_abnormal_hepatobiliary_system0.56661744
134MP0003566_abnormal_cell_adhesion0.56631293

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.46133570
2Chromsome breakage (HP:0040012)4.26853726
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.19640456
4Reticulocytopenia (HP:0001896)3.80920344
5Ependymoma (HP:0002888)3.75787585
6Medulloblastoma (HP:0002885)3.62246380
7Multiple enchondromatosis (HP:0005701)3.53292796
8Colon cancer (HP:0003003)3.35860271
9Breast hypoplasia (HP:0003187)3.34676794
10Abnormality of the labia minora (HP:0012880)3.31379288
11Progressive muscle weakness (HP:0003323)3.29586675
12Microvesicular hepatic steatosis (HP:0001414)3.27692824
13Selective tooth agenesis (HP:0001592)3.20951324
14Patellar aplasia (HP:0006443)3.14450040
15Progressive external ophthalmoplegia (HP:0000590)3.09929981
16Abnormality of chromosome stability (HP:0003220)3.09830488
17Meckel diverticulum (HP:0002245)3.09814343
18Abnormality of the ileum (HP:0001549)2.97406426
19Oral leukoplakia (HP:0002745)2.95312222
20Abnormality of the preputium (HP:0100587)2.94765746
21Aplasia/Hypoplasia of the patella (HP:0006498)2.92238746
22Abnormal number of incisors (HP:0011064)2.88779443
23Absent radius (HP:0003974)2.87268410
24Supernumerary spleens (HP:0009799)2.84255169
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.81370054
26Absent thumb (HP:0009777)2.80448424
27Ectopic kidney (HP:0000086)2.76869663
28Cortical dysplasia (HP:0002539)2.72329640
29Carpal bone hypoplasia (HP:0001498)2.69569852
30Abnormality of the anterior horn cell (HP:0006802)2.69041369
31Degeneration of anterior horn cells (HP:0002398)2.69041369
32Aplasia involving forearm bones (HP:0009822)2.67239111
33Absent forearm bone (HP:0003953)2.67239111
34Rhabdomyosarcoma (HP:0002859)2.65964751
35Impulsivity (HP:0100710)2.64562866
36Agnosia (HP:0010524)2.63389545
37Myelodysplasia (HP:0002863)2.62577006
38Rough bone trabeculation (HP:0100670)2.52606204
39Aplastic anemia (HP:0001915)2.51998616
40High anterior hairline (HP:0009890)2.51942785
41Astrocytoma (HP:0009592)2.50828616
42Abnormality of the astrocytes (HP:0100707)2.50828616
43Abnormality of cells of the erythroid lineage (HP:0012130)2.49728602
44Glioma (HP:0009733)2.43617839
45Duplicated collecting system (HP:0000081)2.42647899
46Abnormal number of erythroid precursors (HP:0012131)2.41172956
47Duodenal stenosis (HP:0100867)2.39985070
48Small intestinal stenosis (HP:0012848)2.39985070
4911 pairs of ribs (HP:0000878)2.39556788
50Premature graying of hair (HP:0002216)2.37844872
51Septate vagina (HP:0001153)2.36067840
52Hyperacusis (HP:0010780)2.34387750
53Abnormal lung lobation (HP:0002101)2.34348984
54Neoplasm of the oral cavity (HP:0100649)2.33086980
55Cerebral hypomyelination (HP:0006808)2.30964768
56Basal cell carcinoma (HP:0002671)2.30435043
57Bone marrow hypocellularity (HP:0005528)2.29239332
58Abnormality of the fetal cardiovascular system (HP:0010948)2.28861745
59Abnormal umbilical cord blood vessels (HP:0011403)2.28861745
60Single umbilical artery (HP:0001195)2.28861745
61Sloping forehead (HP:0000340)2.28015914
62Proximal placement of thumb (HP:0009623)2.26247511
63Abnormality of glycolysis (HP:0004366)2.25933489
64Deviation of the thumb (HP:0009603)2.24925239
65Volvulus (HP:0002580)2.24052045
66Horseshoe kidney (HP:0000085)2.23623727
67Increased nuchal translucency (HP:0010880)2.19625565
68Tracheoesophageal fistula (HP:0002575)2.19476275
69Atresia of the external auditory canal (HP:0000413)2.18059365
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.18014331
71Missing ribs (HP:0000921)2.17704590
72Neoplasm of the pancreas (HP:0002894)2.17124065
73Neoplasm of striated muscle (HP:0009728)2.16581294
74Spastic diplegia (HP:0001264)2.14572586
75Abnormality of the umbilical cord (HP:0010881)2.14335336
76Choanal atresia (HP:0000453)2.14016497
77Amaurosis fugax (HP:0100576)2.13313044
78Abnormality of the renal collecting system (HP:0004742)2.12270343
79Rib fusion (HP:0000902)2.11876249
80Abnormality of DNA repair (HP:0003254)2.09218382
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08043704
82Cellular immunodeficiency (HP:0005374)2.07985067
83Short thumb (HP:0009778)2.07375715
84Urethral obstruction (HP:0000796)2.07253218
85Abnormality of abdominal situs (HP:0011620)2.06722795
86Abdominal situs inversus (HP:0003363)2.06722795
87Abnormality of the carotid arteries (HP:0005344)2.06555739
88Facial cleft (HP:0002006)2.06222879
89Nephroblastoma (Wilms tumor) (HP:0002667)2.05932039
90Abnormality of the duodenum (HP:0002246)2.05493005
91Triphalangeal thumb (HP:0001199)2.02750892
92Abnormality of cochlea (HP:0000375)2.02240573
93Squamous cell carcinoma (HP:0002860)2.00675576
94Asplenia (HP:0001746)1.99974197
95Anal stenosis (HP:0002025)1.98285682
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97927185
97Embryonal neoplasm (HP:0002898)1.97495446
98Intestinal fistula (HP:0100819)1.97325209
99Dysmetric saccades (HP:0000641)1.97163623
100Pallor (HP:0000980)1.96646697
101Trismus (HP:0000211)1.95923952
102Overlapping toe (HP:0001845)1.94237358
103Supernumerary bones of the axial skeleton (HP:0009144)1.93721320
104Prominent nose (HP:0000448)1.93634228
105Ragged-red muscle fibers (HP:0003200)1.93244109
106Macrocytic anemia (HP:0001972)1.92778547
107Embryonal renal neoplasm (HP:0011794)1.90539574
108Skull defect (HP:0001362)1.90152878
109Deep philtrum (HP:0002002)1.89261528
110Aplasia/hypoplasia of the humerus (HP:0006507)1.88305475
111Cafe-au-lait spot (HP:0000957)1.88081255
112Neoplasm of the adrenal cortex (HP:0100641)1.87889711
113Pendular nystagmus (HP:0012043)1.87320933
114Lymphoma (HP:0002665)1.87052587
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.86041791
116Rectovaginal fistula (HP:0000143)1.84920486
117Rectal fistula (HP:0100590)1.84920486
118Optic nerve coloboma (HP:0000588)1.84810705
119Premature ovarian failure (HP:0008209)1.82838739
120Abnormality of chromosome segregation (HP:0002916)1.82174638
121Asymmetry of the thorax (HP:0001555)1.80678812
122Abnormality of oral frenula (HP:0000190)1.80452983
123Increased serum pyruvate (HP:0003542)1.79482850
124Clubbing of toes (HP:0100760)1.79326898
125Preauricular skin tag (HP:0000384)1.79252625
126Overriding aorta (HP:0002623)1.78669108
127Insomnia (HP:0100785)1.78085458
128Long eyelashes (HP:0000527)1.76071274
129Supernumerary ribs (HP:0005815)1.75808502
130Congenital stationary night blindness (HP:0007642)1.75459744
131Cleft eyelid (HP:0000625)1.75456309
132Abnormal trabecular bone morphology (HP:0100671)1.75232396
133Ankyloglossia (HP:0010296)1.72203448
134Trigonocephaly (HP:0000243)1.72090440
135Capillary hemangiomas (HP:0005306)1.72081072
136Glossoptosis (HP:0000162)1.71278667
137Abnormality of the calcaneus (HP:0008364)1.70256006
138Sensory axonal neuropathy (HP:0003390)1.69495349
139Broad distal phalanx of finger (HP:0009836)1.69024277
140Abnormality of homocysteine metabolism (HP:0010919)1.66714552
141Homocystinuria (HP:0002156)1.66714552
142Secondary amenorrhea (HP:0000869)1.65243448
143Ulnar bowing (HP:0003031)1.64944995
144Orthostatic hypotension (HP:0001278)1.64319674
145Duplication of thumb phalanx (HP:0009942)1.63091964
146Arteriovenous malformation (HP:0100026)1.62614107
147Impaired proprioception (HP:0010831)1.62032281
148Obsessive-compulsive behavior (HP:0000722)1.59141651
149Shoulder girdle muscle weakness (HP:0003547)1.58986056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.22471844
2WEE13.79899787
3BUB13.61699322
4SMG13.50086907
5CDK123.11003205
6TSSK63.03310870
7SRPK12.99349496
8EIF2AK12.75181898
9TTK2.73269448
10NEK22.39401981
11PASK2.25567590
12MKNK12.17041342
13ATR2.03505479
14VRK22.03429087
15PLK12.02032498
16PLK42.01587420
17MKNK22.00685860
18TAF11.98871077
19CDK71.95590440
20BRSK21.94894327
21NEK11.87057394
22RPS6KB21.85266676
23PLK31.81026993
24BRD41.71334197
25EEF2K1.69866158
26EPHA21.66038048
27TLK11.63769327
28CHEK21.63653730
29AURKB1.62365634
30ICK1.58061622
31CHEK11.55758688
32VRK11.48001289
33CDK41.46693271
34EIF2AK31.43255181
35ZAK1.43121538
36ALK1.39758245
37STK101.37680150
38TESK21.34914978
39MAP3K81.34665540
40ACVR1B1.31932127
41TRIB31.28631323
42STK41.20257591
43RPS6KA41.19381019
44ATM1.17575924
45TGFBR11.14123934
46NME21.12541593
47STK161.12364506
48PIM11.12071639
49MAP4K11.10398564
50AURKA1.09862712
51CDK21.08581708
52BRSK11.00517504
53CDK80.98981373
54PRPF4B0.98458634
55DYRK30.96077683
56IRAK30.94644539
57PAK40.91839059
58MAP3K100.90849640
59PNCK0.88576848
60CDK10.81594649
61CSNK2A20.79279028
62CAMK1G0.77930205
63CAMK1D0.77499267
64STK38L0.75976286
65FLT30.74626442
66CLK10.74112842
67MELK0.73632558
68PKN20.72544148
69TAOK20.72065710
70TRIM280.68513237
71CDK60.67826287
72MTOR0.66459639
73LATS20.65754435
74CCNB10.65507073
75EIF2AK20.64584215
76TXK0.62997738
77CSNK2A10.62608660
78ERBB40.62161938
79PIM20.61658494
80STK30.57278676
81SCYL20.56256383
82PBK0.55511869
83FGFR40.55495063
84PRKCI0.55226281
85RPS6KA50.53690095
86CSNK1E0.53015254
87MST1R0.51946105
88AKT30.51746167
89PRKDC0.51567368
90PAK10.49521422
91AKT20.46700811
92MAPK140.46426556
93TEC0.46318546
94MAP2K30.45837544
95PDGFRA0.45293248
96CSNK1G30.44968699
97JAK30.44605385
98CSNK1G10.43789444
99FGFR10.42823602
100BTK0.42603104
101RAF10.42594357
102CSNK1A1L0.42467660
103TTN0.42405559
104DAPK10.41590460
105CSNK1D0.41103702
106CHUK0.39628526
107MAP3K90.38536660
108PAK20.37698336
109NTRK10.36913176
110CDK90.36447265
111LRRK20.34983669
112PDK20.34424847
113MAP3K30.34340169
114RPS6KB10.34004577
115YES10.33497992
116MAPK110.32802651
117GSK3B0.32646509
118CDK11A0.31043804
119AKT10.30776594
120CDK30.30640314
121MST40.29894717
122NME10.29527120
123ZAP700.29260858
124MAPK10.29094529
125CSF1R0.27771569
126CDK150.27323950
127CDK180.27299487
128BRAF0.27236772
129LATS10.24874402
130MARK30.24142563

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61531171
2Mismatch repair_Homo sapiens_hsa034304.33966812
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08703553
4Spliceosome_Homo sapiens_hsa030403.48358050
5RNA transport_Homo sapiens_hsa030133.32202718
6RNA polymerase_Homo sapiens_hsa030203.17489235
7One carbon pool by folate_Homo sapiens_hsa006703.09435784
8Homologous recombination_Homo sapiens_hsa034403.03368371
9Base excision repair_Homo sapiens_hsa034103.02027397
10Ribosome_Homo sapiens_hsa030102.96606537
11Nucleotide excision repair_Homo sapiens_hsa034202.86742714
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.82237157
13Cell cycle_Homo sapiens_hsa041102.67631288
14Fanconi anemia pathway_Homo sapiens_hsa034602.54465106
15Proteasome_Homo sapiens_hsa030502.32001640
16Pyrimidine metabolism_Homo sapiens_hsa002402.24914736
17Non-homologous end-joining_Homo sapiens_hsa034502.21968943
18RNA degradation_Homo sapiens_hsa030182.15592717
19mRNA surveillance pathway_Homo sapiens_hsa030152.08218216
20Basal transcription factors_Homo sapiens_hsa030221.99533015
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76670803
22p53 signaling pathway_Homo sapiens_hsa041151.52421161
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49758091
24Purine metabolism_Homo sapiens_hsa002301.27475991
25Epstein-Barr virus infection_Homo sapiens_hsa051691.22193913
26Systemic lupus erythematosus_Homo sapiens_hsa053221.15558311
27Carbon metabolism_Homo sapiens_hsa012001.14192758
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11426301
29Herpes simplex infection_Homo sapiens_hsa051681.05384033
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04123068
31Viral carcinogenesis_Homo sapiens_hsa052031.03761653
32Cyanoamino acid metabolism_Homo sapiens_hsa004600.98483884
33Pyruvate metabolism_Homo sapiens_hsa006200.90833824
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90568808
35HTLV-I infection_Homo sapiens_hsa051660.86409659
36Steroid biosynthesis_Homo sapiens_hsa001000.85058578
37Antigen processing and presentation_Homo sapiens_hsa046120.82376494
38MicroRNAs in cancer_Homo sapiens_hsa052060.80003872
39Phototransduction_Homo sapiens_hsa047440.79397190
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78069732
41Oocyte meiosis_Homo sapiens_hsa041140.74959349
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74401828
43Primary immunodeficiency_Homo sapiens_hsa053400.74375304
44Biosynthesis of amino acids_Homo sapiens_hsa012300.73370097
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73062137
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.70253973
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69207384
48Non-small cell lung cancer_Homo sapiens_hsa052230.68927460
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63926838
50Pancreatic cancer_Homo sapiens_hsa052120.63281085
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63201497
52Small cell lung cancer_Homo sapiens_hsa052220.62909632
53Selenocompound metabolism_Homo sapiens_hsa004500.62585869
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62288146
55Thyroid cancer_Homo sapiens_hsa052160.61954068
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61110287
57Notch signaling pathway_Homo sapiens_hsa043300.58447548
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.57884437
59TGF-beta signaling pathway_Homo sapiens_hsa043500.57259440
60Basal cell carcinoma_Homo sapiens_hsa052170.56149482
61Measles_Homo sapiens_hsa051620.55440980
62Hippo signaling pathway_Homo sapiens_hsa043900.53927343
63Endometrial cancer_Homo sapiens_hsa052130.53286187
64Pentose phosphate pathway_Homo sapiens_hsa000300.50747427
65Legionellosis_Homo sapiens_hsa051340.49431410
66Colorectal cancer_Homo sapiens_hsa052100.46817430
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46275274
68Chronic myeloid leukemia_Homo sapiens_hsa052200.42752010
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.42000056
70Lysine degradation_Homo sapiens_hsa003100.41124430
71Apoptosis_Homo sapiens_hsa042100.40719809
72Hepatitis B_Homo sapiens_hsa051610.40682451
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40459823
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39972399
75Alcoholism_Homo sapiens_hsa050340.39569247
76Glioma_Homo sapiens_hsa052140.39121557
77HIF-1 signaling pathway_Homo sapiens_hsa040660.38461079
78Fructose and mannose metabolism_Homo sapiens_hsa000510.37986549
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.37849477
80Allograft rejection_Homo sapiens_hsa053300.37397855
81Acute myeloid leukemia_Homo sapiens_hsa052210.36532534
82Pathways in cancer_Homo sapiens_hsa052000.35501185
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33828345
84Renal cell carcinoma_Homo sapiens_hsa052110.33691834
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33460854
86Sulfur relay system_Homo sapiens_hsa041220.31594664
87Viral myocarditis_Homo sapiens_hsa054160.30657167
88Folate biosynthesis_Homo sapiens_hsa007900.30606238
89mTOR signaling pathway_Homo sapiens_hsa041500.30525589
90Hedgehog signaling pathway_Homo sapiens_hsa043400.28581174
91Protein export_Homo sapiens_hsa030600.28528101
92Hematopoietic cell lineage_Homo sapiens_hsa046400.28077590
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27771787
94Type I diabetes mellitus_Homo sapiens_hsa049400.26961531
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26795704
96Adherens junction_Homo sapiens_hsa045200.26305429
97Influenza A_Homo sapiens_hsa051640.26222880
98T cell receptor signaling pathway_Homo sapiens_hsa046600.26011275
99Autoimmune thyroid disease_Homo sapiens_hsa053200.25994391
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25297596
101Vitamin B6 metabolism_Homo sapiens_hsa007500.24980843
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24346794
103Proteoglycans in cancer_Homo sapiens_hsa052050.23960706
104Prostate cancer_Homo sapiens_hsa052150.23749329
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23643252
106Bladder cancer_Homo sapiens_hsa052190.22965516
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22886340
108Insulin signaling pathway_Homo sapiens_hsa049100.22826984
109Wnt signaling pathway_Homo sapiens_hsa043100.22230363
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21915573
111AMPK signaling pathway_Homo sapiens_hsa041520.21710888
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.21385247
113Galactose metabolism_Homo sapiens_hsa000520.20940562
114Fatty acid elongation_Homo sapiens_hsa000620.20916535
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.19996673
116Shigellosis_Homo sapiens_hsa051310.19261377
117Arginine and proline metabolism_Homo sapiens_hsa003300.19193632
118Glutathione metabolism_Homo sapiens_hsa004800.18180855
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18052507
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17740685
121Asthma_Homo sapiens_hsa053100.17449555
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16626831
123N-Glycan biosynthesis_Homo sapiens_hsa005100.16243458
124Melanoma_Homo sapiens_hsa052180.16112182

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