ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.08183506
2	base-excision repair, AP site formation (GO:0006285)	4.07686621
3	metallo-sulfur cluster assembly (GO:0031163)	3.89912794
4	iron-sulfur cluster assembly (GO:0016226)	3.89912794
5	DNA deamination (GO:0045006)	3.88051688
6	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.78381303
7	tRNA modification (GO:0006400)	3.70044595
8	negative regulation of B cell apoptotic process (GO:0002903)	3.66953983
9	GDP-mannose metabolic process (GO:0019673)	3.50752472
10	pyrimidine nucleotide catabolic process (GO:0006244)	3.43901242
11	dosage compensation (GO:0007549)	3.42206732
12	protein complex biogenesis (GO:0070271)	3.26892505
13	phosphatidylglycerol biosynthetic process (GO:0006655)	3.24351920
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19401958
15	L-fucose catabolic process (GO:0042355)	3.16938711
16	fucose catabolic process (GO:0019317)	3.16938711
17	L-fucose metabolic process (GO:0042354)	3.16938711
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.15157908
19	positive regulation of granulocyte differentiation (GO:0030854)	3.15040406
20	pseudouridine synthesis (GO:0001522)	3.14781074
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.14771712
22	NADH dehydrogenase complex assembly (GO:0010257)	3.14771712
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.14771712
24	meiotic chromosome segregation (GO:0045132)	3.09466024
25	mannosylation (GO:0097502)	3.07972688
26	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.02568924
27	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.02104498
28	deoxyribonucleotide catabolic process (GO:0009264)	2.99068775
29	replication fork processing (GO:0031297)	2.98285946
30	negative regulation of telomere maintenance (GO:0032205)	2.97046379
31	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.96980365
32	axoneme assembly (GO:0035082)	2.96586287
33	purine deoxyribonucleotide catabolic process (GO:0009155)	2.93941667
34	histone H3-K9 methylation (GO:0051567)	2.89069787
35	rRNA modification (GO:0000154)	2.89008751
36	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.88404634
37	ubiquinone biosynthetic process (GO:0006744)	2.84858391
38	response to misfolded protein (GO:0051788)	2.84670315
39	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.83656545
40	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.82856740
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82694752
42	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.82557312
43	rRNA catabolic process (GO:0016075)	2.81479108
44	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.79975411
45	cilium or flagellum-dependent cell motility (GO:0001539)	2.79328258
46	cellular response to exogenous dsRNA (GO:0071360)	2.77329489
47	tRNA processing (GO:0008033)	2.73683572
48	snRNA processing (GO:0016180)	2.73009182
49	DNA replication checkpoint (GO:0000076)	2.73002358
50	cytochrome complex assembly (GO:0017004)	2.70083761
51	mismatch repair (GO:0006298)	2.65843611
52	maturation of SSU-rRNA (GO:0030490)	2.65613073
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.64093083
54	deoxyribose phosphate catabolic process (GO:0046386)	2.62674861
55	peptidyl-histidine modification (GO:0018202)	2.61441011
56	RNA modification (GO:0009451)	2.61364800
57	regulation of mitochondrial translation (GO:0070129)	2.60820314
58	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.59779558
59	negative regulation of mRNA processing (GO:0050686)	2.59104740
60	mRNA splice site selection (GO:0006376)	2.59048539
61	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.58339026
62	establishment of mitochondrion localization (GO:0051654)	2.58221445
63	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.58175973
64	ribosomal small subunit assembly (GO:0000028)	2.58081106
65	Peyers patch development (GO:0048541)	2.56881239
66	mucosal-associated lymphoid tissue development (GO:0048537)	2.56881239
67	DNA strand renaturation (GO:0000733)	2.56031202
68	ubiquinone metabolic process (GO:0006743)	2.55559859
69	nucleosome disassembly (GO:0006337)	2.55462747
70	protein-DNA complex disassembly (GO:0032986)	2.55462747
71	pyrimidine dimer repair (GO:0006290)	2.54211809
72	DNA modification (GO:0006304)	2.54157920
73	kinetochore assembly (GO:0051382)	2.54062601
74	negative thymic T cell selection (GO:0045060)	2.53817019
75	telomere maintenance via semi-conservative replication (GO:0032201)	2.52578786
76	translesion synthesis (GO:0019985)	2.51396946
77	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.50858656
78	respiratory chain complex IV assembly (GO:0008535)	2.50646487
79	transcription from RNA polymerase III promoter (GO:0006383)	2.50184534
80	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.49850104
81	purine deoxyribonucleotide metabolic process (GO:0009151)	2.48578161
82	mast cell activation involved in immune response (GO:0002279)	2.48572687
83	mast cell degranulation (GO:0043303)	2.48572687
84	DNA strand elongation involved in DNA replication (GO:0006271)	2.46856200
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46615255
86	amino acid salvage (GO:0043102)	2.44804837
87	L-methionine salvage (GO:0071267)	2.44804837
88	L-methionine biosynthetic process (GO:0071265)	2.44804837
89	reciprocal DNA recombination (GO:0035825)	2.44005388
90	reciprocal meiotic recombination (GO:0007131)	2.44005388
91	rRNA methylation (GO:0031167)	2.41611319
92	2-deoxyribonucleotide metabolic process (GO:0009394)	2.41400059
93	snRNA metabolic process (GO:0016073)	2.40962637
94	negative regulation of cell aging (GO:0090344)	2.40735092
95	response to pheromone (GO:0019236)	2.40325699
96	histone H3-K9 modification (GO:0061647)	2.39114068
97	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.37249398
98	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.37249398
99	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.37100480
100	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.37100480

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.08609108
2	CIITA_25753668_ChIP-Seq_RAJI_Human	2.87471949
3	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.86592027
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.70520561
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.69298330
6	VDR_21846776_ChIP-Seq_THP-1_Human	2.69038808
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.68243207
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.57775015
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41423571
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.29485566
11	XRN2_22483619_ChIP-Seq_HELA_Human	2.29464816
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.25903641
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.20976668
14	GABP_19822575_ChIP-Seq_HepG2_Human	2.07996075
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.02573373
16	P68_20966046_ChIP-Seq_HELA_Human	2.01745438
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01283139
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98048613
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.98021298
20	MYC_22102868_ChIP-Seq_BL_Human	1.97427058
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90534361
22	KDM5A_27292631_Chip-Seq_BREAST_Human	1.89455561
23	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88043969
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87990104
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.86664931
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.80812436
27	BCL6_27268052_Chip-Seq_Bcells_Human	1.79975282
28	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.79327396
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79080790
30	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.77491498
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77484135
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.74402558
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72035509
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.71637266
35	MAF_26560356_Chip-Seq_TH2_Human	1.70714272
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.66703973
37	PHF8_20622854_ChIP-Seq_HELA_Human	1.64009551
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.62751523
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.61712355
40	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.56849626
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55062956
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.53769494
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.52243692
44	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51882656
45	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.50326985
46	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.50286144
47	BCOR_27268052_Chip-Seq_Bcells_Human	1.50100294
48	ERA_21632823_ChIP-Seq_H3396_Human	1.44691863
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.44043800
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.42237118
51	UTX_26944678_Chip-Seq_JUKART_Human	1.41534241
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.39775982
53	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.39703111
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.38489161
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.37278976
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36370630
57	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.34571413
58	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.34525560
59	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.33573368
60	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.31035692
61	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29635645
62	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29432656
63	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.27578131
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.25301283
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23627449
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.23209597
67	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23113871
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.23048677
69	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.22647452
70	CTCF_20526341_ChIP-Seq_ESCs_Human	1.21880978
71	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.21036236
72	MAF_26560356_Chip-Seq_TH1_Human	1.20364372
73	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19863521
74	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.19618954
75	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19214776
76	SMC4_20622854_ChIP-Seq_HELA_Human	1.18140165
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.18042905
78	P300_27268052_Chip-Seq_Bcells_Human	1.17994763
79	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.17309853
80	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15430368
81	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15138574
82	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13473805
83	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12399450
84	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.11102241
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.10934580
86	LXR_22292898_ChIP-Seq_THP-1_Human	1.10884771
87	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.09474119
88	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07253670
89	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.05311254
90	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.04671908
91	CTCF_27219007_Chip-Seq_Bcells_Human	1.04420772
92	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04237257
93	CTCF_21964334_Chip-Seq_Bcells_Human	1.04116839
94	RAC3_21632823_ChIP-Seq_H3396_Human	1.03533878
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03341725
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02950810
97	EZH2_22144423_ChIP-Seq_EOC_Human	1.02759790
98	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.01540113
99	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.01460109
100	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.01329665

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	2.82994895
2	MP0001986_abnormal_taste_sensitivity	2.81516815
3	MP0010094_abnormal_chromosome_stability	2.55896080
4	MP0005423_abnormal_somatic_nervous	2.53479567
5	MP0003136_yellow_coat_color	2.46104577
6	MP0008058_abnormal_DNA_repair	2.22147258
7	MP0006292_abnormal_olfactory_placode	2.21912869
8	MP0008995_early_reproductive_senescence	2.18280261
9	MP0005645_abnormal_hypothalamus_physiol	2.13248043
10	MP0002736_abnormal_nociception_after	1.92454733
11	MP0003111_abnormal_nucleus_morphology	1.88060585
12	MP0002735_abnormal_chemical_nociception	1.86122573
13	MP0002822_catalepsy	1.84437016
14	MP0006276_abnormal_autonomic_nervous	1.84362448
15	MP0002653_abnormal_ependyma_morphology	1.80695725
16	MP0009278_abnormal_bone_marrow	1.78738526
17	MP0005174_abnormal_tail_pigmentation	1.73190116
18	MP0005646_abnormal_pituitary_gland	1.71000053
19	MP0001188_hyperpigmentation	1.69560881
20	MP0003693_abnormal_embryo_hatching	1.65481344
21	MP0003787_abnormal_imprinting	1.58005193
22	MP0006035_abnormal_mitochondrial_morpho	1.57957597
23	MP0005551_abnormal_eye_electrophysiolog	1.51342422
24	MP0003786_premature_aging	1.48570799
25	MP0005499_abnormal_olfactory_system	1.48182040
26	MP0005394_taste/olfaction_phenotype	1.48182040
27	MP0001502_abnormal_circadian_rhythm	1.46250206
28	MP0003763_abnormal_thymus_physiology	1.38938616
29	MP0001905_abnormal_dopamine_level	1.37359675
30	MP0009745_abnormal_behavioral_response	1.34519696
31	MP0004043_abnormal_pH_regulation	1.34309509
32	MP0009046_muscle_twitch	1.34170656
33	MP0004859_abnormal_synaptic_plasticity	1.32873231
34	MP0003635_abnormal_synaptic_transmissio	1.29138980
35	MP0005171_absent_coat_pigmentation	1.27941810
36	MP0008872_abnormal_physiological_respon	1.27845937
37	MP0004142_abnormal_muscle_tone	1.24932771
38	MP0001529_abnormal_vocalization	1.21155044
39	MP0002638_abnormal_pupillary_reflex	1.20791037
40	MP0001970_abnormal_pain_threshold	1.20487888
41	MP0005083_abnormal_biliary_tract	1.19882072
42	MP0003077_abnormal_cell_cycle	1.19502767
43	MP0004133_heterotaxia	1.17770549
44	MP0003880_abnormal_central_pattern	1.15084223
45	MP0002063_abnormal_learning/memory/cond	1.14791434
46	MP0000631_abnormal_neuroendocrine_gland	1.14311288
47	MP0002572_abnormal_emotion/affect_behav	1.14182516
48	MP0001984_abnormal_olfaction	1.14035287
49	MP0008877_abnormal_DNA_methylation	1.13973197
50	MP0008057_abnormal_DNA_replication	1.12012846
51	MP0005075_abnormal_melanosome_morpholog	1.12006166
52	MP0004381_abnormal_hair_follicle	1.11594494
53	MP0002733_abnormal_thermal_nociception	1.10744642
54	MP0002064_seizures	1.07529490
55	MP0005253_abnormal_eye_physiology	1.07451559
56	MP0006072_abnormal_retinal_apoptosis	1.07296450
57	MP0005671_abnormal_response_to	1.06652473
58	MP0002396_abnormal_hematopoietic_system	1.05246190
59	MP0000703_abnormal_thymus_morphology	1.04597561
60	MP0001346_abnormal_lacrimal_gland	1.03875223
61	MP0002272_abnormal_nervous_system	1.03299513
62	MP0004147_increased_porphyrin_level	1.03177969
63	MP0002398_abnormal_bone_marrow	1.03037222
64	MP0006036_abnormal_mitochondrial_physio	1.02217869
65	MP0002557_abnormal_social/conspecific_i	1.01716801
66	MP0001800_abnormal_humoral_immune	1.01290437
67	MP0002019_abnormal_tumor_incidence	0.98807901
68	MP0002160_abnormal_reproductive_system	0.97518901
69	MP0001486_abnormal_startle_reflex	0.95817064
70	MP0005220_abnormal_exocrine_pancreas	0.93990979
71	MP0003698_abnormal_male_reproductive	0.93969139
72	MP0000689_abnormal_spleen_morphology	0.91369643
73	MP0000015_abnormal_ear_pigmentation	0.89262326
74	MP0008789_abnormal_olfactory_epithelium	0.89157196
75	MP0001929_abnormal_gametogenesis	0.88771696
76	MP0008961_abnormal_basal_metabolism	0.88098836
77	MP0002067_abnormal_sensory_capabilities	0.88066724
78	MP0003646_muscle_fatigue	0.87626186
79	MP0002249_abnormal_larynx_morphology	0.83960743
80	MP0000716_abnormal_immune_system	0.83071890
81	MP0008875_abnormal_xenobiotic_pharmacok	0.83001040
82	MP0005386_behavior/neurological_phenoty	0.82252755
83	MP0004924_abnormal_behavior	0.82252755
84	MP0002722_abnormal_immune_system	0.81308600
85	MP0002420_abnormal_adaptive_immunity	0.80968341
86	MP0001819_abnormal_immune_cell	0.78821039
87	MP0001963_abnormal_hearing_physiology	0.78337878
88	MP0000778_abnormal_nervous_system	0.77349383
89	MP0002210_abnormal_sex_determination	0.77222677
90	MP0002752_abnormal_somatic_nervous	0.77196455
91	MP0001873_stomach_inflammation	0.76955912
92	MP0002429_abnormal_blood_cell	0.75964631
93	MP0004742_abnormal_vestibular_system	0.74271721
94	MP0002723_abnormal_immune_serum	0.74154056
95	MP0008007_abnormal_cellular_replicative	0.73852029
96	MP0002102_abnormal_ear_morphology	0.73565817
97	MP0001145_abnormal_male_reproductive	0.73496500
98	MP0000026_abnormal_inner_ear	0.72814641
99	MP0002009_preneoplasia	0.72553484
100	MP0000358_abnormal_cell_content/	0.72531723

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	3.75312289
2	Retinal dysplasia (HP:0007973)	3.12637160
3	Patellar aplasia (HP:0006443)	3.06189208
4	Cerebellar dysplasia (HP:0007033)	3.03959249
5	Abnormal number of erythroid precursors (HP:0012131)	3.01248338
6	Panhypogammaglobulinemia (HP:0003139)	3.01105649
7	Aplasia/Hypoplasia of the patella (HP:0006498)	2.87837939
8	Congenital stationary night blindness (HP:0007642)	2.83614684
9	Hypoplasia of the pons (HP:0012110)	2.79006772
10	Type II lissencephaly (HP:0007260)	2.75427957
11	Attenuation of retinal blood vessels (HP:0007843)	2.65008497
12	Abnormality of cells of the erythroid lineage (HP:0012130)	2.62577628
13	Nephronophthisis (HP:0000090)	2.61891210
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55994868
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.55518492
16	Hepatocellular necrosis (HP:0001404)	2.54128263
17	Abnormality of the pons (HP:0007361)	2.53530987
18	Rib fusion (HP:0000902)	2.52696493
19	Progressive microcephaly (HP:0000253)	2.51847188
20	Chronic hepatic failure (HP:0100626)	2.45852728
21	Pancreatic cysts (HP:0001737)	2.44037356
22	Reticulocytopenia (HP:0001896)	2.42435397
23	Abnormality of midbrain morphology (HP:0002418)	2.36077678
24	Molar tooth sign on MRI (HP:0002419)	2.36077678
25	Poikiloderma (HP:0001029)	2.35657248
26	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.30648364
27	Agammaglobulinemia (HP:0004432)	2.30279528
28	Absent thumb (HP:0009777)	2.30121148
29	Abnormality of DNA repair (HP:0003254)	2.30046358
30	Testicular atrophy (HP:0000029)	2.28860061
31	Mitochondrial inheritance (HP:0001427)	2.26941000
32	Severe combined immunodeficiency (HP:0004430)	2.23493040
33	Increased intramyocellular lipid droplets (HP:0012240)	2.21586081
34	Lissencephaly (HP:0001339)	2.21330356
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17014544
36	Abnormality of the renal medulla (HP:0100957)	2.15248395
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.14597820
38	Increased CSF lactate (HP:0002490)	2.13893502
39	Ragged-red muscle fibers (HP:0003200)	2.13369116
40	Increased muscle lipid content (HP:0009058)	2.12104195
41	Chromsome breakage (HP:0040012)	2.09313406
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.09123721
43	True hermaphroditism (HP:0010459)	2.08508399
44	Abnormal biliary tract physiology (HP:0012439)	2.06200333
45	Bile duct proliferation (HP:0001408)	2.06200333
46	Pancreatic fibrosis (HP:0100732)	2.06085085
47	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.04135552
48	IgG deficiency (HP:0004315)	2.03184097
49	Optic nerve coloboma (HP:0000588)	2.01664288
50	3-Methylglutaconic aciduria (HP:0003535)	2.01652089
51	Abnormality of the renal collecting system (HP:0004742)	2.01418049
52	Duplicated collecting system (HP:0000081)	2.01184980
53	Lipid accumulation in hepatocytes (HP:0006561)	2.01064230
54	Absent speech (HP:0001344)	2.00209413
55	Abnormality of the columella (HP:0009929)	1.99439756
56	Abnormal mitochondria in muscle tissue (HP:0008316)	1.98429731
57	Stomach cancer (HP:0012126)	1.95527853
58	Squamous cell carcinoma (HP:0002860)	1.93617416
59	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93487831
60	Dicarboxylic aciduria (HP:0003215)	1.93042003
61	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93042003
62	Hepatic necrosis (HP:0002605)	1.92939384
63	Short thumb (HP:0009778)	1.92866429
64	Inability to walk (HP:0002540)	1.91923997
65	Increased serum lactate (HP:0002151)	1.91805771
66	Abnormality of B cell number (HP:0010975)	1.91316021
67	Increased hepatocellular lipid droplets (HP:0006565)	1.90195888
68	Genetic anticipation (HP:0003743)	1.88077960
69	Methylmalonic aciduria (HP:0012120)	1.87978146
70	Tubulointerstitial nephritis (HP:0001970)	1.87009633
71	Acute lymphatic leukemia (HP:0006721)	1.85285593
72	Decreased central vision (HP:0007663)	1.82419511
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.81877380
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.81877380
75	Abnormal protein glycosylation (HP:0012346)	1.81877380
76	Abnormal glycosylation (HP:0012345)	1.81877380
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81187144
78	Abnormality of the ileum (HP:0001549)	1.79132838
79	Intestinal fistula (HP:0100819)	1.78335934
80	Protruding tongue (HP:0010808)	1.78009086
81	Sloping forehead (HP:0000340)	1.77556941
82	Meckel diverticulum (HP:0002245)	1.75899183
83	Medial flaring of the eyebrow (HP:0010747)	1.75665986
84	Clumsiness (HP:0002312)	1.73282413
85	B lymphocytopenia (HP:0010976)	1.71209297
86	Hypoplasia of the brainstem (HP:0002365)	1.69783515
87	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.69783515
88	Tented upper lip vermilion (HP:0010804)	1.69308740
89	Impulsivity (HP:0100710)	1.69189022
90	Polydipsia (HP:0001959)	1.67774511
91	Abnormal drinking behavior (HP:0030082)	1.67774511
92	Occipital encephalocele (HP:0002085)	1.67467459
93	Homocystinuria (HP:0002156)	1.67458063
94	Abnormality of homocysteine metabolism (HP:0010919)	1.67458063
95	Opisthotonus (HP:0002179)	1.67038248
96	Cystic liver disease (HP:0006706)	1.66596488
97	Absent radius (HP:0003974)	1.65854038
98	Broad distal phalanx of finger (HP:0009836)	1.65827708
99	High anterior hairline (HP:0009890)	1.65667251
100	Progressive inability to walk (HP:0002505)	1.64375153

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.56169692
2	TLK1	3.22425095
3	SIK2	3.05949787
4	MAP4K2	2.65721251
5	BCKDK	2.57599517
6	MAPK15	2.50081353
7	TAOK3	2.45006689
8	MAP4K1	2.22079368
9	MAP2K7	2.15179700
10	SRPK1	1.97453139
11	TNK2	1.94358939
12	PIM2	1.85797748
13	WNK4	1.81183532
14	VRK2	1.73448911
15	FRK	1.67913296
16	CSNK1A1L	1.61630167
17	CDK12	1.60917531
18	STK16	1.57297430
19	ATR	1.56881318
20	MAP3K4	1.55428868
21	MAPK13	1.53618242
22	TXK	1.52796403
23	NUAK1	1.52272015
24	GRK6	1.50086016
25	TRIM28	1.45809657
26	CSNK1G3	1.45232521
27	RPS6KA5	1.41047656
28	DYRK2	1.35408723
29	NME1	1.35160104
30	VRK1	1.34053988
31	TESK2	1.34010391
32	CDC7	1.29364940
33	MAP3K11	1.26055163
34	BTK	1.18255548
35	PINK1	1.09659095
36	KDR	1.07153427
37	KIT	1.05313433
38	NTRK2	1.03996695
39	CSNK1G2	1.01884369
40	CSNK1G1	1.01026808
41	CDK4	0.99088397
42	ADRBK2	0.95402648
43	AURKA	0.95250732
44	BMPR1B	0.95194284
45	DAPK2	0.94415396
46	PIM1	0.92006970
47	MAPK11	0.90347751
48	EEF2K	0.85007371
49	MAP2K6	0.84902980
50	CHEK2	0.84742605
51	SYK	0.84694458
52	IKBKB	0.83933391
53	NEK2	0.83780748
54	INSRR	0.81544765
55	MAP2K4	0.80118175
56	CAMKK1	0.79511461
57	CCNB1	0.79433019
58	FES	0.79063649
59	ITK	0.71550829
60	WNK3	0.70444012
61	RPS6KA6	0.69657511
62	MAP3K7	0.69583244
63	TEC	0.69037855
64	MATK	0.68699979
65	FLT3	0.67932173
66	DAPK1	0.67925385
67	MAPKAPK5	0.63468054
68	IKBKE	0.61946496
69	PKN1	0.61876381
70	MARK2	0.61399459
71	BRD4	0.61332624
72	CDK2	0.59229602
73	MKNK1	0.58722296
74	BLK	0.58481731
75	LYN	0.58213212
76	TBK1	0.56518308
77	PRKAA1	0.56056214
78	PRKCQ	0.55158384
79	ATM	0.54585694
80	CHEK1	0.53050202
81	CAMK1	0.52380360
82	RPS6KC1	0.51846673
83	RPS6KL1	0.51846673
84	PLK1	0.51454971
85	LCK	0.51140555
86	MAPK12	0.46700859
87	CSF1R	0.46384478
88	MARK1	0.46206699
89	MAPK3	0.45145789
90	MAPK8	0.43306238
91	CAMK1D	0.42171594
92	PRKCI	0.41984567
93	CDK7	0.41942951
94	RPS6KA1	0.41861680
95	CAMK4	0.41831372
96	EPHA4	0.41486030
97	CSNK1A1	0.41183823
98	CDK1	0.40318301
99	CDK19	0.37656593
100	CSNK1D	0.37512853

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	3.46811606
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.43612384
3	Base excision repair_Homo sapiens_hsa03410	3.40451398
4	DNA replication_Homo sapiens_hsa03030	3.19308061
5	Homologous recombination_Homo sapiens_hsa03440	3.10787154
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.77175283
7	RNA polymerase_Homo sapiens_hsa03020	2.73601219
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.59208037
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.40622228
10	Ribosome_Homo sapiens_hsa03010	1.96081816
11	Pyrimidine metabolism_Homo sapiens_hsa00240	1.95167500
12	Nicotine addiction_Homo sapiens_hsa05033	1.92619564
13	Spliceosome_Homo sapiens_hsa03040	1.89031367
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86518703
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.85037398
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83528294
17	Mismatch repair_Homo sapiens_hsa03430	1.82309389
18	Phototransduction_Homo sapiens_hsa04744	1.81814061
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.79510752
20	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.62653441
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62619341
22	RNA degradation_Homo sapiens_hsa03018	1.58188316
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.55811329
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55797522
25	Asthma_Homo sapiens_hsa05310	1.47997656
26	Purine metabolism_Homo sapiens_hsa00230	1.38557282
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36558262
28	RNA transport_Homo sapiens_hsa03013	1.36049768
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.32295295
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31313473
31	Taste transduction_Homo sapiens_hsa04742	1.28434537
32	Alcoholism_Homo sapiens_hsa05034	1.27047174
33	Lysine degradation_Homo sapiens_hsa00310	1.25271614
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.15572502
35	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.13593256
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.13282028
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12067071
38	Basal transcription factors_Homo sapiens_hsa03022	1.08129778
39	Parkinsons disease_Homo sapiens_hsa05012	1.07689283
40	Allograft rejection_Homo sapiens_hsa05330	1.04889422
41	Morphine addiction_Homo sapiens_hsa05032	1.03657126
42	One carbon pool by folate_Homo sapiens_hsa00670	1.02257145
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01947925
44	Olfactory transduction_Homo sapiens_hsa04740	1.00516976
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.99298806
46	Huntingtons disease_Homo sapiens_hsa05016	0.98544278
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98475346
48	Butanoate metabolism_Homo sapiens_hsa00650	0.96814610
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.95320686
50	Regulation of autophagy_Homo sapiens_hsa04140	0.93781193
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.90799269
52	ABC transporters_Homo sapiens_hsa02010	0.85383729
53	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83674393
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77755047
55	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77689702
56	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.74810653
57	Peroxisome_Homo sapiens_hsa04146	0.74554172
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74428300
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74268370
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.73154502
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.72949002
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70910406
63	GABAergic synapse_Homo sapiens_hsa04727	0.70876615
64	Herpes simplex infection_Homo sapiens_hsa05168	0.69630206
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.63636284
66	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.56536589
67	Cell cycle_Homo sapiens_hsa04110	0.55864745
68	Circadian entrainment_Homo sapiens_hsa04713	0.55378202
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53593990
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.50503818
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49650060
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47793867
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47415096
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.47273703
75	Metabolic pathways_Homo sapiens_hsa01100	0.46178248
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.44819232
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42414254
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40633934
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39416035
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.38365955
81	Circadian rhythm_Homo sapiens_hsa04710	0.37609887
82	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34878838
83	Cocaine addiction_Homo sapiens_hsa05030	0.33833346
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32030773
85	Alzheimers disease_Homo sapiens_hsa05010	0.32013937
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.30945766
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30332090
88	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29275560
89	Antigen processing and presentation_Homo sapiens_hsa04612	0.28039794
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27241026
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.26916000
92	Cholinergic synapse_Homo sapiens_hsa04725	0.24369756
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23734729
94	Salivary secretion_Homo sapiens_hsa04970	0.22517214
95	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.21354446
96	Nitrogen metabolism_Homo sapiens_hsa00910	0.20514838
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.19301787
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.19228015
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18601588
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.18551214

RRP7BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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