RRP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.84307660
2ribosomal small subunit assembly (GO:0000028)4.76594541
3DNA strand elongation involved in DNA replication (GO:0006271)4.71825496
4nucleobase biosynthetic process (GO:0046112)4.70786615
5DNA replication initiation (GO:0006270)4.47433219
6DNA strand elongation (GO:0022616)4.46522806
7IMP biosynthetic process (GO:0006188)4.46071438
8protein prenylation (GO:0018342)4.46069980
9prenylation (GO:0097354)4.46069980
10DNA unwinding involved in DNA replication (GO:0006268)4.41920293
11telomere maintenance via semi-conservative replication (GO:0032201)4.39645189
12purine nucleobase biosynthetic process (GO:0009113)4.38744268
13formation of translation preinitiation complex (GO:0001731)4.35748693
14DNA deamination (GO:0045006)4.28878527
15ribosomal large subunit biogenesis (GO:0042273)4.24483508
16ribosome assembly (GO:0042255)4.22153785
17folic acid-containing compound biosynthetic process (GO:0009396)4.16483197
18ribosome biogenesis (GO:0042254)4.14450586
19ribosomal small subunit biogenesis (GO:0042274)4.11931910
20viral transcription (GO:0019083)4.11712018
21translational termination (GO:0006415)4.11211944
22ribonucleoprotein complex biogenesis (GO:0022613)4.11068055
23IMP metabolic process (GO:0046040)4.02188211
24DNA replication checkpoint (GO:0000076)3.97367697
25mitotic metaphase plate congression (GO:0007080)3.93049090
26telomere maintenance via recombination (GO:0000722)3.90843731
27translational elongation (GO:0006414)3.80696407
28protein localization to kinetochore (GO:0034501)3.78913776
29mitotic nuclear envelope disassembly (GO:0007077)3.76970168
30translational initiation (GO:0006413)3.75759097
31CENP-A containing nucleosome assembly (GO:0034080)3.75128717
32respiratory chain complex IV assembly (GO:0008535)3.70064593
33mitotic recombination (GO:0006312)3.68409155
34* rRNA processing (GO:0006364)3.67835506
35chromatin remodeling at centromere (GO:0031055)3.63575231
36platelet dense granule organization (GO:0060155)3.62231140
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58295215
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57387152
39nuclear pore organization (GO:0006999)3.56621851
40telomere maintenance via telomere lengthening (GO:0010833)3.55356695
41rRNA modification (GO:0000154)3.54498733
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54204026
43* rRNA metabolic process (GO:0016072)3.54078580
44DNA replication-dependent nucleosome assembly (GO:0006335)3.52426128
45DNA replication-dependent nucleosome organization (GO:0034723)3.52426128
46nuclear envelope disassembly (GO:0051081)3.48815892
47membrane disassembly (GO:0030397)3.48815892
48cotranslational protein targeting to membrane (GO:0006613)3.48006184
49protein targeting to ER (GO:0045047)3.47461620
50DNA replication-independent nucleosome organization (GO:0034724)3.46578076
51DNA replication-independent nucleosome assembly (GO:0006336)3.46578076
52L-fucose catabolic process (GO:0042355)3.45362661
53fucose catabolic process (GO:0019317)3.45362661
54L-fucose metabolic process (GO:0042354)3.45362661
55replication fork processing (GO:0031297)3.41688329
56folic acid metabolic process (GO:0046655)3.40729710
57nuclear pore complex assembly (GO:0051292)3.38838495
58spliceosomal snRNP assembly (GO:0000387)3.38800231
59metaphase plate congression (GO:0051310)3.37073215
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36886977
61pseudouridine synthesis (GO:0001522)3.34848466
62protein localization to chromosome, centromeric region (GO:0071459)3.33963856
63proteasome assembly (GO:0043248)3.31048536
64S-adenosylmethionine metabolic process (GO:0046500)3.30523184
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29210788
66protein localization to endoplasmic reticulum (GO:0070972)3.28862012
67synapsis (GO:0007129)3.23318415
68cellular protein complex disassembly (GO:0043624)3.21293862
69protein import into peroxisome matrix (GO:0016558)3.21167479
70maturation of 5.8S rRNA (GO:0000460)3.19904668
71regulation of spindle organization (GO:0090224)3.19311401
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.19152974
73viral life cycle (GO:0019058)3.17314724
74viral mRNA export from host cell nucleus (GO:0046784)3.17165062
75histone H2A acetylation (GO:0043968)3.16841659
76kinetochore organization (GO:0051383)3.16629578
77cytochrome complex assembly (GO:0017004)3.16316880
78RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16030021
79protein complex biogenesis (GO:0070271)3.14955227
80water-soluble vitamin biosynthetic process (GO:0042364)3.14107821
81positive regulation of prostaglandin secretion (GO:0032308)3.13893539
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11314696
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.11314696
84NADH dehydrogenase complex assembly (GO:0010257)3.11314696
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10552044
86translation (GO:0006412)3.09482184
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07697891
88mitochondrial respiratory chain complex assembly (GO:0033108)3.05730328
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.05529249
90termination of RNA polymerase III transcription (GO:0006386)3.05529249
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04382497
92male meiosis I (GO:0007141)3.04350056
93preassembly of GPI anchor in ER membrane (GO:0016254)3.04154238
94cell cycle G1/S phase transition (GO:0044843)3.03441064
95G1/S transition of mitotic cell cycle (GO:0000082)3.03441064
96double-strand break repair via homologous recombination (GO:0000724)3.02894947
97DNA double-strand break processing (GO:0000729)3.02781789
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02671553
99cellular component biogenesis (GO:0044085)3.02539601
100recombinational repair (GO:0000725)3.01625992
101histone exchange (GO:0043486)3.01448000
102regulation of meiosis I (GO:0060631)3.00429008
103protein K11-linked deubiquitination (GO:0035871)3.00316652
104protein K6-linked ubiquitination (GO:0085020)2.99914290
105establishment of chromosome localization (GO:0051303)2.98742170
106negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98558431
107negative regulation of translation, ncRNA-mediated (GO:0040033)2.98558431
108regulation of translation, ncRNA-mediated (GO:0045974)2.98558431
109establishment of integrated proviral latency (GO:0075713)2.97340500
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96443392
111transcription-coupled nucleotide-excision repair (GO:0006283)2.96313081
112spliceosomal complex assembly (GO:0000245)2.96022498
113parental behavior (GO:0060746)2.95122703
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.91859784
115protein complex disassembly (GO:0043241)2.90544128
116rRNA methylation (GO:0031167)2.90039703
117DNA duplex unwinding (GO:0032508)2.89961733
118kinetochore assembly (GO:0051382)2.89850875
119DNA geometric change (GO:0032392)2.88105833
120termination of RNA polymerase I transcription (GO:0006363)2.86943377
121negative regulation of DNA-dependent DNA replication (GO:2000104)2.85897887
122glucosamine-containing compound catabolic process (GO:1901072)2.85152468
123mannosylation (GO:0097502)2.84700133
124* ncRNA processing (GO:0034470)2.83619089
125intracellular protein transmembrane import (GO:0044743)2.82741948
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.80073442
127attachment of spindle microtubules to kinetochore (GO:0008608)2.79880036
128negative regulation of ligase activity (GO:0051352)2.79619751
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79619751
130transcription from RNA polymerase I promoter (GO:0006360)2.78419233
131chromatin assembly or disassembly (GO:0006333)2.78174893
132ether lipid metabolic process (GO:0046485)2.78144278
133mRNA catabolic process (GO:0006402)2.77266861
134tRNA methylation (GO:0030488)2.76841868
135macromolecular complex disassembly (GO:0032984)2.76767035
136nuclear envelope organization (GO:0006998)2.75918142
137cellular ketone body metabolic process (GO:0046950)2.75867452
138* ncRNA metabolic process (GO:0034660)2.75332004
139RNA catabolic process (GO:0006401)2.74989800
140telomere organization (GO:0032200)2.74879735
141telomere maintenance (GO:0000723)2.74430866
142peptidyl-histidine modification (GO:0018202)2.74366421
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72835489
144positive regulation of fatty acid transport (GO:2000193)2.71890036
145piRNA metabolic process (GO:0034587)2.71661671
146dopamine transport (GO:0015872)2.71056118
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70274643
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.70274643
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67503782
150base-excision repair, AP site formation (GO:0006285)2.65301573
151mitochondrial RNA metabolic process (GO:0000959)2.64789603
152indolalkylamine metabolic process (GO:0006586)2.62257042
153protein-cofactor linkage (GO:0018065)2.60134338
154DNA catabolic process, exonucleolytic (GO:0000738)2.59270888
155meiotic chromosome segregation (GO:0045132)2.59194083
156DNA-dependent DNA replication (GO:0006261)2.55578037
157positive regulation of icosanoid secretion (GO:0032305)2.55468620
158ketone body metabolic process (GO:1902224)2.55415958
159pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.52279502
160behavioral response to nicotine (GO:0035095)2.51504492
161detection of light stimulus involved in sensory perception (GO:0050962)2.50599072
162detection of light stimulus involved in visual perception (GO:0050908)2.50599072
163methionine biosynthetic process (GO:0009086)2.50181081
164DNA methylation involved in gamete generation (GO:0043046)2.50169656
165signal peptide processing (GO:0006465)2.48330329
166reciprocal DNA recombination (GO:0035825)2.48318035
167reciprocal meiotic recombination (GO:0007131)2.48318035
168negative regulation of T-helper cell differentiation (GO:0045623)2.48053199
169negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.48053199
170lactate metabolic process (GO:0006089)2.47672838
171inositol phosphate catabolic process (GO:0071545)2.45368403
172RNA destabilization (GO:0050779)2.39755914
173GPI anchor metabolic process (GO:0006505)2.39722156
174meiosis I (GO:0007127)2.38211526
175dentate gyrus development (GO:0021542)2.37744559
176response to xenobiotic stimulus (GO:0009410)2.37545282
177tRNA processing (GO:0008033)2.37122779
178positive regulation of uterine smooth muscle contraction (GO:0070474)2.37101525
179tryptophan metabolic process (GO:0006568)2.37065450
180negative regulation of alpha-beta T cell differentiation (GO:0046639)2.35711884
181sister chromatid cohesion (GO:0007062)2.35666470
182regulation of glucokinase activity (GO:0033131)2.33880434
183regulation of hexokinase activity (GO:1903299)2.33880434
184heparin biosynthetic process (GO:0030210)2.33830513
185heparin metabolic process (GO:0030202)2.33830513
186cell wall macromolecule metabolic process (GO:0044036)2.33481372
187mitochondrial DNA replication (GO:0006264)2.33351561
188postreplication repair (GO:0006301)2.31908244
189histone mRNA metabolic process (GO:0008334)2.30146172
190regulation of DNA endoreduplication (GO:0032875)2.29534657
191phosphorylated carbohydrate dephosphorylation (GO:0046838)2.28871317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05651843
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.25111498
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.52495571
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89401949
5ZNF274_21170338_ChIP-Seq_K562_Hela3.65129444
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.38111919
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27792299
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20504269
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06667642
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.94519752
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.94440547
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93098508
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91950103
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91372221
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86680137
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84297746
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.83734738
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58676136
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44495973
20XRN2_22483619_ChIP-Seq_HELA_Human2.37080682
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34406387
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25063534
23* VDR_23849224_ChIP-Seq_CD4+_Human2.22455414
24AR_21909140_ChIP-Seq_LNCAP_Human2.19218793
25EWS_26573619_Chip-Seq_HEK293_Human2.18193066
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11283554
27DCP1A_22483619_ChIP-Seq_HELA_Human2.10983935
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.07401525
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07238802
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99064631
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96847422
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94383847
33FOXP3_21729870_ChIP-Seq_TREG_Human1.92836448
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92318899
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.89954165
36GABP_19822575_ChIP-Seq_HepG2_Human1.89088898
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88448305
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86483510
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84106965
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83518137
41* TTF2_22483619_ChIP-Seq_HELA_Human1.82269499
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82008561
43IGF1R_20145208_ChIP-Seq_DFB_Human1.81479277
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.79292847
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76021419
46ELK1_19687146_ChIP-ChIP_HELA_Human1.72699495
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72136473
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70571876
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66086330
50FUS_26573619_Chip-Seq_HEK293_Human1.65488545
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65140861
52MYC_22102868_ChIP-Seq_BL_Human1.64109404
53CIITA_25753668_ChIP-Seq_RAJI_Human1.60729960
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60547034
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60221368
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59129995
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57930181
58VDR_22108803_ChIP-Seq_LS180_Human1.56931189
59TAF15_26573619_Chip-Seq_HEK293_Human1.56416621
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.56318875
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53520690
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52243137
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50638728
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49219335
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48055619
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46714837
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.44788150
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.44560172
69ER_23166858_ChIP-Seq_MCF-7_Human1.43269464
70KDM5A_27292631_Chip-Seq_BREAST_Human1.38682432
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38313161
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36242730
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34679630
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32898935
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32231072
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31733059
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31687262
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.31469566
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30151312
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27767771
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26725137
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26359177
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26270835
84P300_19829295_ChIP-Seq_ESCs_Human1.25980562
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25702276
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22378196
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22312677
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22057271
89TP53_22573176_ChIP-Seq_HFKS_Human1.21104608
90GATA3_26560356_Chip-Seq_TH2_Human1.20898196
91TFEB_21752829_ChIP-Seq_HELA_Human1.20318087
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20025374
93IRF1_19129219_ChIP-ChIP_H3396_Human1.16944716
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15621297
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14744348
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14034772
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13029095
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.12342305
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11540848
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09318216
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08757912
102IRF8_22096565_ChIP-ChIP_GC-B_Human1.07432696
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06593023
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06380229
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05025544
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04794479
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04692442
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04123012
109STAT3_23295773_ChIP-Seq_U87_Human1.02265258
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99856533
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.99833714
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99596887
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97891513
114SPI1_23547873_ChIP-Seq_NB4_Human0.97771693
115FOXA1_25329375_ChIP-Seq_VCAP_Human0.97524018
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97524018
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97456089
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97068941
119CBP_20019798_ChIP-Seq_JUKART_Human0.97068941
120VDR_21846776_ChIP-Seq_THP-1_Human0.96640666
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96055808
122SOX2_19829295_ChIP-Seq_ESCs_Human0.94984085
123NANOG_19829295_ChIP-Seq_ESCs_Human0.94984085
124TCF4_23295773_ChIP-Seq_U87_Human0.94790146
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94217740
126MYC_18940864_ChIP-ChIP_HL60_Human0.93242387
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.92522236
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92491827
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92242109
130SMAD4_21799915_ChIP-Seq_A2780_Human0.91937762
131GBX2_23144817_ChIP-Seq_PC3_Human0.91156026
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.90420727
133AR_20517297_ChIP-Seq_VCAP_Human0.88594200
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.88217057
135NCOR_22424771_ChIP-Seq_293T_Human0.87710581
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87681840
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86980910
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86607056
139PHF8_20622853_ChIP-Seq_HELA_Human0.85877167
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85716369
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.85294873
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85207014
143BCAT_22108803_ChIP-Seq_LS180_Human0.85159647
144* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84824696
145GATA3_26560356_Chip-Seq_TH1_Human0.83486767
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.83237941
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83153894
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82916027
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82026364
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82008176
151TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78136849
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76734009
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74780358
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74466562
155FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73114440
156OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72798827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.48409905
2MP0004957_abnormal_blastocyst_morpholog4.19072847
3MP0003111_abnormal_nucleus_morphology4.05375550
4MP0010094_abnormal_chromosome_stability3.91236675
5MP0003077_abnormal_cell_cycle3.59321792
6MP0008057_abnormal_DNA_replication3.07571584
7MP0008058_abnormal_DNA_repair2.89503914
8MP0000015_abnormal_ear_pigmentation2.70950601
9MP0008007_abnormal_cellular_replicative2.67413279
10MP0008932_abnormal_embryonic_tissue2.54713430
11MP0002396_abnormal_hematopoietic_system2.53886501
12MP0002837_dystrophic_cardiac_calcinosis2.44448544
13MP0003123_paternal_imprinting2.38300754
14MP0004142_abnormal_muscle_tone2.33299689
15MP0003646_muscle_fatigue2.18191821
16MP0010352_gastrointestinal_tract_polyps2.16287326
17MP0001730_embryonic_growth_arrest2.14269105
18MP0003195_calcinosis2.10693663
19MP0000372_irregular_coat_pigmentation2.09304052
20MP0000350_abnormal_cell_proliferation2.06991716
21MP0006072_abnormal_retinal_apoptosis2.04308858
22MP0005645_abnormal_hypothalamus_physiol1.98997143
23MP0005253_abnormal_eye_physiology1.96149026
24MP0002876_abnormal_thyroid_physiology1.93360430
25MP0006292_abnormal_olfactory_placode1.93000838
26MP0002102_abnormal_ear_morphology1.86183696
27MP0010030_abnormal_orbit_morphology1.81741067
28MP0003786_premature_aging1.75093472
29MP0009697_abnormal_copulation1.70305952
30MP0008877_abnormal_DNA_methylation1.67318569
31MP0002095_abnormal_skin_pigmentation1.67106969
32MP0000490_abnormal_crypts_of1.64153075
33MP0001986_abnormal_taste_sensitivity1.61248735
34MP0000685_abnormal_immune_system1.61215452
35MP0004808_abnormal_hematopoietic_stem1.60453719
36MP0005551_abnormal_eye_electrophysiolog1.59139467
37MP0003806_abnormal_nucleotide_metabolis1.58955466
38MP0003718_maternal_effect1.58679519
39MP0001697_abnormal_embryo_size1.58397326
40MP0005380_embryogenesis_phenotype1.58188103
41MP0001672_abnormal_embryogenesis/_devel1.58188103
42MP0010307_abnormal_tumor_latency1.55943190
43MP0005379_endocrine/exocrine_gland_phen1.54186617
44MP0009333_abnormal_splenocyte_physiolog1.54108420
45MP0005174_abnormal_tail_pigmentation1.51364155
46MP0002080_prenatal_lethality1.49555008
47MP0003567_abnormal_fetal_cardiomyocyte1.46687630
48MP0006054_spinal_hemorrhage1.45539267
49MP0000516_abnormal_urinary_system1.43188742
50MP0005367_renal/urinary_system_phenotyp1.43188742
51MP0002138_abnormal_hepatobiliary_system1.43109610
52MP0003984_embryonic_growth_retardation1.40795841
53MP0002088_abnormal_embryonic_growth/wei1.39426252
54MP0000371_diluted_coat_color1.38181032
55MP0003763_abnormal_thymus_physiology1.34686452
56MP0001764_abnormal_homeostasis1.32655724
57MP0002019_abnormal_tumor_incidence1.32372935
58MP0004197_abnormal_fetal_growth/weight/1.31751755
59MP0004147_increased_porphyrin_level1.31554880
60MP0002938_white_spotting1.31340847
61MP0003566_abnormal_cell_adhesion1.30871656
62MP0005023_abnormal_wound_healing1.30726391
63MP0002085_abnormal_embryonic_tissue1.30361192
64MP0009046_muscle_twitch1.29713059
65MP0001545_abnormal_hematopoietic_system1.28194008
66MP0005397_hematopoietic_system_phenotyp1.28194008
67MP0005408_hypopigmentation1.27207715
68MP0003186_abnormal_redox_activity1.27173114
69MP0000427_abnormal_hair_cycle1.26483252
70MP0001929_abnormal_gametogenesis1.25407511
71MP0001835_abnormal_antigen_presentation1.24774790
72MP0002928_abnormal_bile_duct1.24627917
73MP0002086_abnormal_extraembryonic_tissu1.23746506
74MP0000313_abnormal_cell_death1.22830047
75MP0002163_abnormal_gland_morphology1.21358380
76MP0000569_abnormal_digit_pigmentation1.20368585
77MP0008438_abnormal_cutaneous_collagen1.19658577
78MP0001968_abnormal_touch/_nociception1.18130560
79MP0000537_abnormal_urethra_morphology1.17136644
80MP0002084_abnormal_developmental_patter1.15793675
81MP0005220_abnormal_exocrine_pancreas1.15734613
82MP0002693_abnormal_pancreas_physiology1.15692258
83MP0003705_abnormal_hypodermis_morpholog1.14889631
84MP0002132_abnormal_respiratory_system1.13909345
85MP0008995_early_reproductive_senescence1.13774694
86MP0001853_heart_inflammation1.13471698
87MP0006035_abnormal_mitochondrial_morpho1.13112216
88MP0000703_abnormal_thymus_morphology1.11716478
89MP0000631_abnormal_neuroendocrine_gland1.10651565
90MP0000858_altered_metastatic_potential1.09033539
91MP0001944_abnormal_pancreas_morphology1.07195039
92MP0002398_abnormal_bone_marrow1.06611423
93MP0005084_abnormal_gallbladder_morpholo1.05074443
94MP0002722_abnormal_immune_system1.04799170
95MP0005647_abnormal_sex_gland1.03895316
96MP0010386_abnormal_urinary_bladder1.02234909
97MP0003787_abnormal_imprinting1.01418195
98MP0003698_abnormal_male_reproductive1.00609855
99MP0000689_abnormal_spleen_morphology0.99285628
100MP0005332_abnormal_amino_acid0.99023975
101MP0001293_anophthalmia0.98786820
102MP0008872_abnormal_physiological_respon0.97413872
103MP0001873_stomach_inflammation0.97335917
104MP0005410_abnormal_fertilization0.95267264
105MP0000358_abnormal_cell_content/0.94376682
106MP0003121_genomic_imprinting0.94246784
107MP0000465_gastrointestinal_hemorrhage0.92998381
108MP0003315_abnormal_perineum_morphology0.92350232
109MP0005083_abnormal_biliary_tract0.91670541
110MP0008875_abnormal_xenobiotic_pharmacok0.90093635
111MP0009053_abnormal_anal_canal0.89631807
112MP0009379_abnormal_foot_pigmentation0.87476704
113MP0000750_abnormal_muscle_regeneration0.87129242
114MP0000538_abnormal_urinary_bladder0.84027356
115MP0003941_abnormal_skin_development0.83142373
116MP0002429_abnormal_blood_cell0.82934815
117MP0001915_intracranial_hemorrhage0.82896878
118MP0002111_abnormal_tail_morphology0.82617714
119MP0005395_other_phenotype0.82607272
120MP0005646_abnormal_pituitary_gland0.81821258
121MP0002723_abnormal_immune_serum0.81257752
122MP0008961_abnormal_basal_metabolism0.80623533
123MP0003221_abnormal_cardiomyocyte_apopto0.80438221
124MP0001542_abnormal_bone_strength0.79118916
125MP0005266_abnormal_metabolism0.79057150
126MP0002210_abnormal_sex_determination0.78473474
127MP0003252_abnormal_bile_duct0.77524975
128MP0005310_abnormal_salivary_gland0.77046555
129MP0002638_abnormal_pupillary_reflex0.75347977
130MP0005384_cellular_phenotype0.75156509
131MP0001243_abnormal_dermal_layer0.75013967
132MP0004043_abnormal_pH_regulation0.75003096
133MP0005000_abnormal_immune_tolerance0.74977627
134MP0002075_abnormal_coat/hair_pigmentati0.73274422
135MP0005621_abnormal_cell_physiology0.72922392
136MP0001119_abnormal_female_reproductive0.72808961
137MP0004145_abnormal_muscle_electrophysio0.71958170
138MP0000716_abnormal_immune_system0.69581834
139MP0001145_abnormal_male_reproductive0.68424140
140MP0003937_abnormal_limbs/digits/tail_de0.67988398
141MP0005076_abnormal_cell_differentiation0.66665813
142MP0005075_abnormal_melanosome_morpholog0.66463686
143MP0005503_abnormal_tendon_morphology0.66168353
144MP0002160_abnormal_reproductive_system0.65219433
145MP0000428_abnormal_craniofacial_morphol0.62530788
146MP0005671_abnormal_response_to0.62527880
147MP0009672_abnormal_birth_weight0.62021169
148MP0003279_aneurysm0.61888327
149MP0002405_respiratory_system_inflammati0.61486296
150MP0005389_reproductive_system_phenotype0.60970626
151MP0000653_abnormal_sex_gland0.60693787
152MP0003890_abnormal_embryonic-extraembry0.58487228
153MP0000733_abnormal_muscle_development0.57880018
154MP0005508_abnormal_skeleton_morphology0.57734816
155MP0003448_altered_tumor_morphology0.57291589
156MP0005275_abnormal_skin_tensile0.56227248
157MP0002452_abnormal_antigen_presenting0.55939237
158MP0000477_abnormal_intestine_morphology0.55066797
159MP0002420_abnormal_adaptive_immunity0.54934440
160MP0006036_abnormal_mitochondrial_physio0.54549179
161MP0001800_abnormal_humoral_immune0.54153176
162MP0003119_abnormal_digestive_system0.53892976
163MP0001819_abnormal_immune_cell0.53309749
164MP0001919_abnormal_reproductive_system0.52698276
165MP0002282_abnormal_trachea_morphology0.52138877

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.66023219
2Abnormality of cells of the erythroid lineage (HP:0012130)4.42203654
3Reticulocytopenia (HP:0001896)4.36545415
4Abnormal number of erythroid precursors (HP:0012131)4.18561593
5Chronic hepatic failure (HP:0100626)3.83401632
6Thyroiditis (HP:0100646)3.65848705
7Pancreatic cysts (HP:0001737)3.57549148
8Albinism (HP:0001022)3.54207597
9Breast hypoplasia (HP:0003187)3.44615914
10Selective tooth agenesis (HP:0001592)3.36734610
11Degeneration of anterior horn cells (HP:0002398)3.33603050
12Abnormality of the anterior horn cell (HP:0006802)3.33603050
13Oral leukoplakia (HP:0002745)3.26033792
14Carpal bone hypoplasia (HP:0001498)3.25017069
15Severe combined immunodeficiency (HP:0004430)3.22639186
16Pallor (HP:0000980)3.20684922
17Rough bone trabeculation (HP:0100670)3.16397782
18Abnormality of midbrain morphology (HP:0002418)3.14299725
19Molar tooth sign on MRI (HP:0002419)3.14299725
20Colon cancer (HP:0003003)3.07309745
21Aplastic anemia (HP:0001915)2.97456739
22B lymphocytopenia (HP:0010976)2.95978087
23Abnormality of the renal cortex (HP:0011035)2.94057099
24Patellar aplasia (HP:0006443)2.93524749
25Macrocytic anemia (HP:0001972)2.91800308
263-Methylglutaconic aciduria (HP:0003535)2.91042247
27Abnormality of B cell number (HP:0010975)2.90729688
28Microretrognathia (HP:0000308)2.86580760
29Pancreatic fibrosis (HP:0100732)2.86167350
30Trismus (HP:0000211)2.83483367
31Panhypogammaglobulinemia (HP:0003139)2.82946129
32Multiple enchondromatosis (HP:0005701)2.82655980
33Aplasia/Hypoplasia of the patella (HP:0006498)2.76859297
34Chromsome breakage (HP:0040012)2.68385211
35Hypothermia (HP:0002045)2.64842629
36Nephronophthisis (HP:0000090)2.64336129
37Congenital stationary night blindness (HP:0007642)2.62708386
38Neoplasm of the adrenal cortex (HP:0100641)2.61592235
39Glossoptosis (HP:0000162)2.57858691
40Thrombocytosis (HP:0001894)2.56824343
4111 pairs of ribs (HP:0000878)2.56231351
42Combined immunodeficiency (HP:0005387)2.56015694
43Increased CSF lactate (HP:0002490)2.55965520
44Renal cortical cysts (HP:0000803)2.54133173
45Attenuation of retinal blood vessels (HP:0007843)2.52025837
46Cerebral hypomyelination (HP:0006808)2.46609472
47Hypoplasia of the thymus (HP:0000778)2.44480546
48Cutaneous melanoma (HP:0012056)2.44007397
49IgG deficiency (HP:0004315)2.41208223
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40364939
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37174196
52True hermaphroditism (HP:0010459)2.36158599
53Meckel diverticulum (HP:0002245)2.33221125
54Hepatic necrosis (HP:0002605)2.32772048
55Absent thumb (HP:0009777)2.32428233
56Homocystinuria (HP:0002156)2.32016238
57Abnormality of homocysteine metabolism (HP:0010919)2.32016238
58Abnormal trabecular bone morphology (HP:0100671)2.30310377
59Slender long bone (HP:0003100)2.29560474
60Abnormality of T cell physiology (HP:0011840)2.28080043
61Abnormality of the renal medulla (HP:0100957)2.27830442
62Mitochondrial inheritance (HP:0001427)2.27612417
63Abnormality of the preputium (HP:0100587)2.27170467
64Protrusio acetabuli (HP:0003179)2.26604309
65Premature graying of hair (HP:0002216)2.26000616
66Abnormality of the umbilical cord (HP:0010881)2.25612457
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25204733
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25204733
69Abnormality of chromosome stability (HP:0003220)2.24584354
70Hepatocellular necrosis (HP:0001404)2.24194602
71Absent radius (HP:0003974)2.22712731
72Progressive muscle weakness (HP:0003323)2.22665770
73Fair hair (HP:0002286)2.22552382
74Myelodysplasia (HP:0002863)2.22310874
75Abnormality of DNA repair (HP:0003254)2.21617373
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17770022
77Neoplasm of the pancreas (HP:0002894)2.15391629
78Missing ribs (HP:0000921)2.15143693
79Methylmalonic acidemia (HP:0002912)2.14631802
80Sparse eyelashes (HP:0000653)2.13330843
81Medial flaring of the eyebrow (HP:0010747)2.12572206
82Progressive macrocephaly (HP:0004481)2.12361933
83Absent forearm bone (HP:0003953)2.12216115
84Aplasia involving forearm bones (HP:0009822)2.12216115
85Delayed CNS myelination (HP:0002188)2.11423396
86Abnormality of the ileum (HP:0001549)2.11213998
87Ketosis (HP:0001946)2.09523285
88Cleft eyelid (HP:0000625)2.08972506
89Ankle contracture (HP:0006466)2.07930591
90Abnormality of methionine metabolism (HP:0010901)2.07173971
91Secondary amenorrhea (HP:0000869)2.06692512
92Premature ovarian failure (HP:0008209)2.06687060
93Volvulus (HP:0002580)2.05821431
94Irregular epiphyses (HP:0010582)2.04388292
95Pendular nystagmus (HP:0012043)2.03549614
96Abnormality of the calcaneus (HP:0008364)2.03195946
97Type I transferrin isoform profile (HP:0003642)2.03052166
98Abnormality of T cells (HP:0002843)2.00626040
99Acute necrotizing encephalopathy (HP:0006965)2.00377298
100Entropion (HP:0000621)2.00335493
101Generalized aminoaciduria (HP:0002909)1.98874402
102Atresia of the external auditory canal (HP:0000413)1.97163332
103Medulloblastoma (HP:0002885)1.97025919
104Short middle phalanx of the 5th finger (HP:0004220)1.96577458
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.96049560
106IgM deficiency (HP:0002850)1.95083846
107Methylmalonic aciduria (HP:0012120)1.94919432
108Cellular immunodeficiency (HP:0005374)1.93312434
109Bone marrow hypocellularity (HP:0005528)1.93254806
110Hyperventilation (HP:0002883)1.93033519
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92101931
112Abnormality of alanine metabolism (HP:0010916)1.92101931
113Hyperalaninemia (HP:0003348)1.92101931
114Muscle fiber atrophy (HP:0100295)1.91070083
115Acute encephalopathy (HP:0006846)1.90157964
116Hematochezia (HP:0002573)1.90090585
117Ureteral duplication (HP:0000073)1.89840864
118Hypoproteinemia (HP:0003075)1.88061827
119Bile duct proliferation (HP:0001408)1.87834265
120Abnormal biliary tract physiology (HP:0012439)1.87834265
121Small intestinal stenosis (HP:0012848)1.87287013
122Duodenal stenosis (HP:0100867)1.87287013
123Squamous cell carcinoma (HP:0002860)1.86622807
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86245434
125Agnosia (HP:0010524)1.86072847
126Absent epiphyses (HP:0010577)1.85467050
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85467050
128Abnormality of vitamin B metabolism (HP:0004340)1.85424313
129Deviation of the thumb (HP:0009603)1.85393462
130Triphalangeal thumb (HP:0001199)1.84390416
131Cervical subluxation (HP:0003308)1.84165474
132Small hand (HP:0200055)1.82947270
133Stomach cancer (HP:0012126)1.82721723
134Pancytopenia (HP:0001876)1.82299785
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.82223517
136Microvesicular hepatic steatosis (HP:0001414)1.82115786
137Basal cell carcinoma (HP:0002671)1.81698642
138Megaloblastic anemia (HP:0001889)1.80844995
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.80500460
140Horseshoe kidney (HP:0000085)1.80479153
141Generalized hypopigmentation of hair (HP:0011358)1.79802008
142Abnormal mitochondria in muscle tissue (HP:0008316)1.79794418
143Calcaneovalgus deformity (HP:0001848)1.78741252
144Type 2 muscle fiber atrophy (HP:0003554)1.78039585
145Poor head control (HP:0002421)1.77566821
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77239332
147Abnormal rod and cone electroretinograms (HP:0008323)1.77170871
148Metaphyseal dysplasia (HP:0100255)1.76990501
149Abnormal number of incisors (HP:0011064)1.76721734
150Furrowed tongue (HP:0000221)1.76258155
151Tracheoesophageal fistula (HP:0002575)1.76158993
152Clubbing of toes (HP:0100760)1.76092365
153Reduced antithrombin III activity (HP:0001976)1.75704125
154Decreased circulating renin level (HP:0003351)1.75632379
155Proximal placement of thumb (HP:0009623)1.75044599
156Rhabdomyosarcoma (HP:0002859)1.74665590
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.74501531
158Constricted visual fields (HP:0001133)1.73994553
159Congenital primary aphakia (HP:0007707)1.73462444
160Sloping forehead (HP:0000340)1.73403689
161Abnormal lung lobation (HP:0002101)1.73041704
162Ependymoma (HP:0002888)1.72396880
163Hypoplasia of the fovea (HP:0007750)1.72143808
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.72143808
165Biconcave vertebral bodies (HP:0004586)1.71747470
166Tubular atrophy (HP:0000092)1.70980404
167T lymphocytopenia (HP:0005403)1.70953969
168Hypoplasia of the radius (HP:0002984)1.70529710
169Abnormality of T cell number (HP:0011839)1.70261921
170Abnormality of reticulocytes (HP:0004312)1.69313890
171Postnatal microcephaly (HP:0005484)1.69293983
172Lactic acidosis (HP:0003128)1.68945315
173Sclerocornea (HP:0000647)1.68121021
174Abnormality of urine glucose concentration (HP:0011016)1.68054767
175Glycosuria (HP:0003076)1.68054767
176Eosinophilia (HP:0001880)1.67824526
177Widely spaced teeth (HP:0000687)1.67773748
178Inability to walk (HP:0002540)1.67526848
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66807190
180Increased serum lactate (HP:0002151)1.66286408
181Abnormality of the metopic suture (HP:0005556)1.66053809
182Stomatitis (HP:0010280)1.65485715
183Ketoacidosis (HP:0001993)1.65039413
184Lymphoma (HP:0002665)1.64947003
185Severe visual impairment (HP:0001141)1.64876746
186High pitched voice (HP:0001620)1.64674134
187Stillbirth (HP:0003826)1.64557260
188Optic disc pallor (HP:0000543)1.64463972
189Increased hepatocellular lipid droplets (HP:0006565)1.64081381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.67467575
2BUB14.23297769
3WEE13.94307166
4MAP4K23.80988174
5CDC73.63023850
6EIF2AK13.22267929
7NME22.89385948
8NUAK12.76088611
9SRPK12.42567752
10NEK22.38310578
11BRSK22.14652854
12CCNB12.09858084
13ACVR1B2.08055155
14PLK42.05808795
15BMPR1B2.05711277
16INSRR2.05065655
17RPS6KA41.96393433
18EIF2AK31.96250380
19PDK21.95755009
20STK161.95112200
21TSSK61.91524082
22TTK1.89021016
23ADRBK21.86060649
24MKNK11.81493180
25TESK21.81056590
26RPS6KB21.75091566
27NEK11.69571501
28GRK11.69490327
29CDK71.69313035
30PLK11.64205086
31PINK11.60829642
32VRK11.59458861
33AKT31.56912307
34PASK1.55183197
35AURKB1.55031163
36STK101.54480499
37MAP3K81.48681729
38TGFBR11.48052448
39TLK11.44607436
40DYRK31.43807627
41TAOK31.42889904
42VRK21.42630802
43MKNK21.42490333
44TXK1.40384625
45PIM21.38133322
46ATR1.37442085
47MAPK131.37012447
48SCYL21.36769355
49KDR1.35465438
50OXSR11.31786554
51STK391.31717406
52EPHA21.31521870
53PLK31.31015366
54EEF2K1.27403996
55WNK41.22167266
56LRRK21.19000126
57WNK31.17561844
58BRSK11.13878725
59ZAK1.11474432
60CDK41.11100332
61CHEK21.10397604
62AURKA1.09107170
63IKBKB1.08131693
64MAP3K41.06936521
65TESK11.06481951
66TRIM281.06175083
67TNIK1.06123027
68MAP4K11.03270169
69FLT31.03063556
70PAK31.01693879
71CHEK10.98897164
72PAK40.96884524
73MAP2K30.94144234
74NTRK30.89551991
75PIM10.85671483
76MAP3K110.82316260
77JAK30.80104624
78CLK10.80020198
79LATS20.79023335
80CSNK1A1L0.78432372
81ZAP700.78114200
82STK40.77931706
83CAMKK20.75139505
84PNCK0.74726431
85PLK20.73945052
86TAOK20.71017021
87MAP2K70.70260876
88PAK10.70142421
89STK38L0.69923672
90CDK20.68187065
91ITK0.68082784
92PHKG20.66806316
93PHKG10.66806316
94MAP2K60.66791822
95CSNK2A20.66056577
96MAPKAPK30.65940235
97CDK80.65605786
98PKN20.65327426
99ERBB30.65162844
100MAP3K100.64735747
101ATM0.63482135
102CSNK2A10.63326465
103RPS6KA50.60988622
104EIF2AK20.60379693
105CSNK1G10.59327181
106BTK0.57928018
107ALK0.57722807
108ILK0.55739737
109MAP3K30.54255900
110STK30.53963774
111CSNK1G30.53750265
112CAMK1G0.51857256
113CDK120.50847920
114CDK60.49916076
115SYK0.49728431
116PAK20.49079243
117IRAK10.48904112
118BCKDK0.48595740
119STK240.48332275
120PKN10.47813251
121NME10.47659676
122HIPK20.47337048
123NEK90.45993436
124CDK10.44871457
125PRKAA10.44459418
126RAF10.43859376
127LIMK10.43790164
128PRKCI0.42548455
129TEC0.42500240
130ABL20.42436015
131TRIB30.41405260
132MST40.40949323
133BRD40.39970532
134BRAF0.39760528
135MELK0.39095916
136MAPK110.38614590
137LYN0.38051602
138PRKCE0.37916466
139FGFR20.37849603
140IRAK30.37408438
141IRAK20.36800120
142PDK30.36246354
143PDK40.36246354
144KIT0.36044911
145ADRBK10.35904644
146DYRK20.35887485
147CSNK1G20.35170337
148MET0.34878873
149PRKACB0.34678994
150PRKAA20.34202692
151PBK0.34023464
152BMPR20.33605516
153BLK0.32337947
154NLK0.32040279
155DAPK10.31536244
156TTN0.31124921
157CSNK1A10.30572816
158PTK2B0.29579059
159MARK30.29208192
160CDK190.28777261

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75165502
2Mismatch repair_Homo sapiens_hsa034303.88271549
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79246281
4Ribosome_Homo sapiens_hsa030103.74360259
5RNA polymerase_Homo sapiens_hsa030203.40108023
6Proteasome_Homo sapiens_hsa030503.37812191
7Spliceosome_Homo sapiens_hsa030403.07981857
8RNA transport_Homo sapiens_hsa030133.07908744
9One carbon pool by folate_Homo sapiens_hsa006702.83296111
10Base excision repair_Homo sapiens_hsa034102.80272425
11Homologous recombination_Homo sapiens_hsa034402.69802654
12Nucleotide excision repair_Homo sapiens_hsa034202.68235246
13Pyrimidine metabolism_Homo sapiens_hsa002402.57240809
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47184731
15Cell cycle_Homo sapiens_hsa041102.45980586
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.42762731
17Butanoate metabolism_Homo sapiens_hsa006502.38442270
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09821106
19Non-homologous end-joining_Homo sapiens_hsa034501.99184341
20Fanconi anemia pathway_Homo sapiens_hsa034601.76541515
21RNA degradation_Homo sapiens_hsa030181.75412529
22Sulfur metabolism_Homo sapiens_hsa009201.74854443
23Basal transcription factors_Homo sapiens_hsa030221.63663632
24p53 signaling pathway_Homo sapiens_hsa041151.63550235
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61916927
26Phototransduction_Homo sapiens_hsa047441.61757887
27Oxidative phosphorylation_Homo sapiens_hsa001901.54688906
28Regulation of autophagy_Homo sapiens_hsa041401.47039617
29mRNA surveillance pathway_Homo sapiens_hsa030151.38295838
30Parkinsons disease_Homo sapiens_hsa050121.36846051
31Purine metabolism_Homo sapiens_hsa002301.29845201
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29050156
33Propanoate metabolism_Homo sapiens_hsa006401.25453333
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24432564
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22922588
36Protein export_Homo sapiens_hsa030601.20379595
37Epstein-Barr virus infection_Homo sapiens_hsa051691.16213319
38Peroxisome_Homo sapiens_hsa041461.15900000
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.12925724
40Systemic lupus erythematosus_Homo sapiens_hsa053221.12588295
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09993613
42Selenocompound metabolism_Homo sapiens_hsa004501.08129348
43Folate biosynthesis_Homo sapiens_hsa007901.06694093
44Caffeine metabolism_Homo sapiens_hsa002321.06190489
45Tryptophan metabolism_Homo sapiens_hsa003801.05397409
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.04235136
47Nitrogen metabolism_Homo sapiens_hsa009101.03367341
48Sulfur relay system_Homo sapiens_hsa041221.03212698
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97863698
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95618800
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95208375
52Viral carcinogenesis_Homo sapiens_hsa052030.95074834
53Linoleic acid metabolism_Homo sapiens_hsa005910.95039734
54Type I diabetes mellitus_Homo sapiens_hsa049400.94930650
55Herpes simplex infection_Homo sapiens_hsa051680.92163055
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91831667
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89052813
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87140941
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.86868739
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.86229950
61Antigen processing and presentation_Homo sapiens_hsa046120.85048651
62Pentose phosphate pathway_Homo sapiens_hsa000300.81087793
63Graft-versus-host disease_Homo sapiens_hsa053320.79593753
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79041740
65HTLV-I infection_Homo sapiens_hsa051660.71600192
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70720271
67Small cell lung cancer_Homo sapiens_hsa052220.70666186
68Vitamin B6 metabolism_Homo sapiens_hsa007500.68934885
69Ether lipid metabolism_Homo sapiens_hsa005650.68576227
70Glutathione metabolism_Homo sapiens_hsa004800.67761547
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.67160221
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66565069
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64572955
74Thyroid cancer_Homo sapiens_hsa052160.64109787
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61363651
76Taste transduction_Homo sapiens_hsa047420.59680450
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59342681
78Legionellosis_Homo sapiens_hsa051340.59306140
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.59188641
80N-Glycan biosynthesis_Homo sapiens_hsa005100.58565574
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58504878
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58353994
83Alzheimers disease_Homo sapiens_hsa050100.57747620
84Fatty acid elongation_Homo sapiens_hsa000620.56169255
85MicroRNAs in cancer_Homo sapiens_hsa052060.56003809
86Allograft rejection_Homo sapiens_hsa053300.55685022
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55279606
88Shigellosis_Homo sapiens_hsa051310.54011390
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53449289
90Chemical carcinogenesis_Homo sapiens_hsa052040.52420200
91Apoptosis_Homo sapiens_hsa042100.52302811
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52003290
93Asthma_Homo sapiens_hsa053100.51126666
94Oocyte meiosis_Homo sapiens_hsa041140.48597441
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47476888
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47285089
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46637157
98TGF-beta signaling pathway_Homo sapiens_hsa043500.46597777
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45769232
100Measles_Homo sapiens_hsa051620.45408731
101Primary immunodeficiency_Homo sapiens_hsa053400.45236475
102Steroid biosynthesis_Homo sapiens_hsa001000.45216227
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44116871
104Carbon metabolism_Homo sapiens_hsa012000.40913231
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.40660310
106Autoimmune thyroid disease_Homo sapiens_hsa053200.38558365
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38324954
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37032217
109Bladder cancer_Homo sapiens_hsa052190.36776486
110Circadian rhythm_Homo sapiens_hsa047100.36008738
111Lysine degradation_Homo sapiens_hsa003100.35965213
112Dorso-ventral axis formation_Homo sapiens_hsa043200.35595967
113Viral myocarditis_Homo sapiens_hsa054160.34398281
114Chronic myeloid leukemia_Homo sapiens_hsa052200.34306221
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34151319
116Hepatitis B_Homo sapiens_hsa051610.33385684
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33068494
118Hematopoietic cell lineage_Homo sapiens_hsa046400.32989659
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31660021
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30310767
121Hippo signaling pathway_Homo sapiens_hsa043900.29080182
122HIF-1 signaling pathway_Homo sapiens_hsa040660.27255215
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26764648
124Acute myeloid leukemia_Homo sapiens_hsa052210.25314130
125Metabolic pathways_Homo sapiens_hsa011000.23899655
126Basal cell carcinoma_Homo sapiens_hsa052170.23788849
127Galactose metabolism_Homo sapiens_hsa000520.23502407
128Huntingtons disease_Homo sapiens_hsa050160.23453707
129Colorectal cancer_Homo sapiens_hsa052100.22784913
130Influenza A_Homo sapiens_hsa051640.21355573
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21202066
132Alcoholism_Homo sapiens_hsa050340.20302105
133Pathways in cancer_Homo sapiens_hsa052000.19470849
134Arginine and proline metabolism_Homo sapiens_hsa003300.18194173
135Renin-angiotensin system_Homo sapiens_hsa046140.17832016
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.16819114
137Arachidonic acid metabolism_Homo sapiens_hsa005900.15772264
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15752441
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14875004
140Adherens junction_Homo sapiens_hsa045200.14671164
141Notch signaling pathway_Homo sapiens_hsa043300.14354640
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13184737
143Leishmaniasis_Homo sapiens_hsa051400.12834454
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.12716959
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12646890
146Prostate cancer_Homo sapiens_hsa052150.12345062
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12096588

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