RRP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.88618899
2DNA deamination (GO:0045006)4.72075759
3DNA replication initiation (GO:0006270)4.60815540
4formation of translation preinitiation complex (GO:0001731)4.59952437
5ribosome biogenesis (GO:0042254)4.57552679
6purine nucleobase biosynthetic process (GO:0009113)4.52703211
7DNA strand elongation involved in DNA replication (GO:0006271)4.52390082
8maturation of SSU-rRNA (GO:0030490)4.47332735
9ribosome assembly (GO:0042255)4.33069601
10DNA strand elongation (GO:0022616)4.30528445
11regulation of translational fidelity (GO:0006450)4.28600009
12establishment of viral latency (GO:0019043)4.28402739
13telomere maintenance via semi-conservative replication (GO:0032201)4.25383408
14folic acid-containing compound biosynthetic process (GO:0009396)4.22686818
15IMP biosynthetic process (GO:0006188)4.20890241
16ribonucleoprotein complex biogenesis (GO:0022613)4.14245932
17DNA unwinding involved in DNA replication (GO:0006268)4.09472981
18mitotic metaphase plate congression (GO:0007080)4.09343978
19protein localization to kinetochore (GO:0034501)4.00629357
20DNA replication checkpoint (GO:0000076)3.99826535
21mitotic nuclear envelope disassembly (GO:0007077)3.99527974
22ribosomal large subunit biogenesis (GO:0042273)3.91863493
23proline biosynthetic process (GO:0006561)3.91013833
24ribosomal small subunit assembly (GO:0000028)3.82941332
25nuclear pore organization (GO:0006999)3.82102581
26DNA replication-dependent nucleosome assembly (GO:0006335)3.76972940
27DNA replication-dependent nucleosome organization (GO:0034723)3.76972940
28* rRNA processing (GO:0006364)3.72077743
29telomere maintenance via recombination (GO:0000722)3.71237409
30mitotic chromosome condensation (GO:0007076)3.70982630
31pseudouridine synthesis (GO:0001522)3.69444408
32spliceosomal snRNP assembly (GO:0000387)3.67572087
33protein maturation by protein folding (GO:0022417)3.67350090
34membrane disassembly (GO:0030397)3.66135728
35nuclear envelope disassembly (GO:0051081)3.66135728
36regulation of mitochondrial translation (GO:0070129)3.64541017
37IMP metabolic process (GO:0046040)3.62710908
38nucleobase-containing small molecule interconversion (GO:0015949)3.60856569
39* rRNA metabolic process (GO:0016072)3.59924702
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.56549314
41folic acid metabolic process (GO:0046655)3.53354746
42nuclear pore complex assembly (GO:0051292)3.52443509
43ribosomal small subunit biogenesis (GO:0042274)3.52035263
44viral transcription (GO:0019083)3.50216731
45rRNA modification (GO:0000154)3.47911500
46translational termination (GO:0006415)3.47412972
47mitotic recombination (GO:0006312)3.47410514
48telomere maintenance via telomere lengthening (GO:0010833)3.46346890
49protein localization to chromosome, centromeric region (GO:0071459)3.45327705
50translational initiation (GO:0006413)3.45052723
51metaphase plate congression (GO:0051310)3.42976593
52translational elongation (GO:0006414)3.29721591
53proteasome assembly (GO:0043248)3.28372266
54CENP-A containing nucleosome assembly (GO:0034080)3.27786533
55transcription from mitochondrial promoter (GO:0006390)3.26827703
56chromatin remodeling at centromere (GO:0031055)3.26706050
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26315050
58rRNA transcription (GO:0009303)3.25851292
59transcription-coupled nucleotide-excision repair (GO:0006283)3.25130231
60mitotic sister chromatid segregation (GO:0000070)3.23962681
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.22893939
62maturation of 5.8S rRNA (GO:0000460)3.21987124
63peptidyl-arginine methylation (GO:0018216)3.21711893
64peptidyl-arginine N-methylation (GO:0035246)3.21711893
65negative regulation of ligase activity (GO:0051352)3.20632656
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20632656
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.20470758
68somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20470758
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.20355998
70termination of RNA polymerase III transcription (GO:0006386)3.20355998
71nuclear envelope reassembly (GO:0031468)3.19658942
72mitotic nuclear envelope reassembly (GO:0007084)3.19658942
73regulation of nuclear cell cycle DNA replication (GO:0033262)3.19063394
74regulation of gene silencing by RNA (GO:0060966)3.18472853
75regulation of posttranscriptional gene silencing (GO:0060147)3.18472853
76regulation of gene silencing by miRNA (GO:0060964)3.18472853
77protein complex localization (GO:0031503)3.14448053
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.14159697
79DNA replication-independent nucleosome assembly (GO:0006336)3.11866460
80DNA replication-independent nucleosome organization (GO:0034724)3.11866460
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09187394
82tRNA aminoacylation for protein translation (GO:0006418)3.07233728
83GDP-mannose metabolic process (GO:0019673)3.06583543
84tRNA methylation (GO:0030488)3.05830034
85DNA duplex unwinding (GO:0032508)3.05657130
86DNA geometric change (GO:0032392)3.03946171
87establishment of chromosome localization (GO:0051303)3.02679129
88Golgi transport vesicle coating (GO:0048200)3.02627409
89COPI coating of Golgi vesicle (GO:0048205)3.02627409
90cellular component biogenesis (GO:0044085)3.02589474
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02556929
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02173295
93tRNA aminoacylation (GO:0043039)3.01082381
94amino acid activation (GO:0043038)3.01082381
95negative regulation of mRNA processing (GO:0050686)2.99086946
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97557237
97regulation of spindle organization (GO:0090224)2.97343579
98establishment of integrated proviral latency (GO:0075713)2.96810703
99heterochromatin organization (GO:0070828)2.96758876
100L-serine metabolic process (GO:0006563)2.96249485
101pentose-phosphate shunt (GO:0006098)2.95904854
102protein K6-linked ubiquitination (GO:0085020)2.95512350
103regulation of translational termination (GO:0006449)2.95145123
104spliceosomal complex assembly (GO:0000245)2.94681743
105termination of RNA polymerase I transcription (GO:0006363)2.94656923
106RNA splicing, via transesterification reactions (GO:0000375)2.94613623
107mitochondrial RNA metabolic process (GO:0000959)2.93255475
108mRNA splicing, via spliceosome (GO:0000398)2.93213513
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93213513
110transcription from RNA polymerase I promoter (GO:0006360)2.92571016
111pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92559544
112kinetochore assembly (GO:0051382)2.92549721
113base-excision repair (GO:0006284)2.91696520
114histone arginine methylation (GO:0034969)2.90956456
115viral mRNA export from host cell nucleus (GO:0046784)2.90328352
116peptidyl-arginine omega-N-methylation (GO:0035247)2.90218911
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90066928
118pteridine-containing compound biosynthetic process (GO:0042559)2.89873007
119protein targeting to mitochondrion (GO:0006626)2.89556172
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88955668
121kinetochore organization (GO:0051383)2.88552657
122* ncRNA processing (GO:0034470)2.88206607
123G1/S transition of mitotic cell cycle (GO:0000082)2.87760536
124cell cycle G1/S phase transition (GO:0044843)2.87760536
125transcription elongation from RNA polymerase I promoter (GO:0006362)2.87504611
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87014093
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86880286
1287-methylguanosine mRNA capping (GO:0006370)2.86591465
129DNA-templated transcription, termination (GO:0006353)2.86433826
130termination of RNA polymerase II transcription (GO:0006369)2.85734148
131nuclear envelope organization (GO:0006998)2.85090264
132regulation of translational elongation (GO:0006448)2.84373632
133NADPH regeneration (GO:0006740)2.84074035
134negative regulation of chromosome segregation (GO:0051985)2.83623053
135negative regulation of RNA splicing (GO:0033119)2.83095940
136SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82174945
137pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.82130517
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82075972
139negative regulation of mRNA metabolic process (GO:1903312)2.82016782
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.81443964
141* ncRNA metabolic process (GO:0034660)2.81020776
142cellular protein complex localization (GO:0034629)2.78873057
143mitochondrial fusion (GO:0008053)2.78170069
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.72094691
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72012258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.54811720
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43943379
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81108283
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.34857079
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23627496
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21391591
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95492084
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95340950
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91774172
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90418093
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.84618429
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.84135588
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76960406
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.67435367
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56063637
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36901067
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32427976
18XRN2_22483619_ChIP-Seq_HELA_Human2.32193717
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31697829
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18412651
21VDR_23849224_ChIP-Seq_CD4+_Human2.12000848
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03822679
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03589831
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02948306
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00891380
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91008868
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89918333
28DCP1A_22483619_ChIP-Seq_HELA_Human1.89900724
29GABP_19822575_ChIP-Seq_HepG2_Human1.88168181
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87455767
31FOXP3_21729870_ChIP-Seq_TREG_Human1.86862029
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85761152
33MYC_22102868_ChIP-Seq_BL_Human1.78313272
34AR_21909140_ChIP-Seq_LNCAP_Human1.76633748
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76253105
36TTF2_22483619_ChIP-Seq_HELA_Human1.75480261
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.75179433
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.71866989
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70208023
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66388343
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63839724
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61744528
43ZNF263_19887448_ChIP-Seq_K562_Human1.61394035
44CIITA_25753668_ChIP-Seq_RAJI_Human1.57715359
45* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54119972
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51709510
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51456965
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51012904
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50927309
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50791286
51KDM5A_27292631_Chip-Seq_BREAST_Human1.48739123
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48578183
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48111427
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46989324
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.43967149
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36579768
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.35072619
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34267961
59ELK1_19687146_ChIP-ChIP_HELA_Human1.33685819
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33260523
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.30534661
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30324328
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.29982173
64* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29706431
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28626154
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24647472
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24588897
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22697038
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17915605
70* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17162871
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17042528
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16665792
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15444828
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15444828
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15444828
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15252531
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.14698614
78TFEB_21752829_ChIP-Seq_HELA_Human1.13980287
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13032391
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.12782495
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12125415
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11932291
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10784528
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09963710
85LXR_22292898_ChIP-Seq_THP-1_Human1.09631963
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08254634
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06732800
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05677711
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05589149
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05580622
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05421531
92VDR_21846776_ChIP-Seq_THP-1_Human1.05307958
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03536623
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01855902
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00446527
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00432765
97* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00094448
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99779002
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99620183
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97964782
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97861945
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97097372
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96660369
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96652106
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96525786
106RACK7_27058665_Chip-Seq_MCF-7_Human0.96322811
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96296084
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95758725
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.95104387
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94563413
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94409010
112* FOXP1_21924763_ChIP-Seq_HESCs_Human0.94323530
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93594110
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93209657
115ATF3_27146783_Chip-Seq_COLON_Human0.92831590
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92664515
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91605902
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91552257
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91518651
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.89334943
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89296475
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.86876285
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86367552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.57985809
2MP0003111_abnormal_nucleus_morphology4.68857533
3MP0004957_abnormal_blastocyst_morpholog4.56234794
4MP0010094_abnormal_chromosome_stability4.44414803
5MP0003077_abnormal_cell_cycle3.97968234
6MP0008057_abnormal_DNA_replication3.94381541
7MP0008058_abnormal_DNA_repair3.45152021
8MP0005451_abnormal_body_composition2.89627856
9MP0008932_abnormal_embryonic_tissue2.74516029
10MP0008007_abnormal_cellular_replicative2.64500330
11MP0010352_gastrointestinal_tract_polyps2.48239488
12MP0001730_embryonic_growth_arrest2.47789618
13MP0002396_abnormal_hematopoietic_system2.39526950
14MP0000350_abnormal_cell_proliferation2.33800972
15MP0003806_abnormal_nucleotide_metabolis2.14108577
16MP0003786_premature_aging2.10732252
17MP0003123_paternal_imprinting2.09064218
18MP0002877_abnormal_melanocyte_morpholog2.06256177
19MP0010307_abnormal_tumor_latency1.94103700
20MP0005380_embryogenesis_phenotype1.90072415
21MP0001672_abnormal_embryogenesis/_devel1.90072415
22MP0004185_abnormal_adipocyte_glucose1.86262052
23MP0003718_maternal_effect1.81091043
24MP0004233_abnormal_muscle_weight1.80642270
25MP0004133_heterotaxia1.78920964
26MP0000490_abnormal_crypts_of1.76756685
27MP0001697_abnormal_embryo_size1.76732249
28MP0003705_abnormal_hypodermis_morpholog1.74417327
29MP0002080_prenatal_lethality1.70502244
30MP0003984_embryonic_growth_retardation1.70015903
31MP0008877_abnormal_DNA_methylation1.69881024
32MP0002088_abnormal_embryonic_growth/wei1.65314303
33MP0002085_abnormal_embryonic_tissue1.63853699
34MP0009333_abnormal_splenocyte_physiolog1.56152119
35MP0002084_abnormal_developmental_patter1.53887671
36MP0002796_impaired_skin_barrier1.53657408
37MP0000313_abnormal_cell_death1.53471253
38MP0008260_abnormal_autophagy1.53293044
39MP0002086_abnormal_extraembryonic_tissu1.48045792
40MP0002019_abnormal_tumor_incidence1.47860018
41MP0001661_extended_life_span1.40862031
42MP0010030_abnormal_orbit_morphology1.40161201
43MP0003763_abnormal_thymus_physiology1.40019833
44MP0009697_abnormal_copulation1.38669922
45MP0005058_abnormal_lysosome_morphology1.37723225
46MP0004197_abnormal_fetal_growth/weight/1.37195777
47MP0006292_abnormal_olfactory_placode1.36595228
48MP0002132_abnormal_respiratory_system1.30842401
49MP0001293_anophthalmia1.30675749
50MP0010234_abnormal_vibrissa_follicle1.28947817
51MP0000358_abnormal_cell_content/1.25073236
52MP0004808_abnormal_hematopoietic_stem1.22999716
53MP0000678_abnormal_parathyroid_gland1.22796739
54MP0005257_abnormal_intraocular_pressure1.22439317
55MP0001545_abnormal_hematopoietic_system1.21268457
56MP0005397_hematopoietic_system_phenotyp1.21268457
57MP0002653_abnormal_ependyma_morphology1.17356864
58MP0000703_abnormal_thymus_morphology1.15008459
59MP0002210_abnormal_sex_determination1.13709281
60MP0003890_abnormal_embryonic-extraembry1.08428854
61MP0003941_abnormal_skin_development1.07914781
62MP0003119_abnormal_digestive_system1.07055651
63MP0002060_abnormal_skin_morphology1.06571554
64MP0002722_abnormal_immune_system1.05189731
65MP0001145_abnormal_male_reproductive1.03438894
66MP0003567_abnormal_fetal_cardiomyocyte1.03087521
67MP0002398_abnormal_bone_marrow1.02709340
68MP0004858_abnormal_nervous_system1.01043763
69MP0000689_abnormal_spleen_morphology1.01004205
70MP0009840_abnormal_foam_cell0.99964786
71MP0003453_abnormal_keratinocyte_physiol0.98569204
72MP0005075_abnormal_melanosome_morpholog0.97879652
73MP0000750_abnormal_muscle_regeneration0.97376693
74MP0002160_abnormal_reproductive_system0.96864683
75MP0001881_abnormal_mammary_gland0.96117687
76MP0000858_altered_metastatic_potential0.94710354
77MP0006035_abnormal_mitochondrial_morpho0.94186605
78MP0005076_abnormal_cell_differentiation0.92776234
79MP0003315_abnormal_perineum_morphology0.88285492
80MP0005384_cellular_phenotype0.88222388
81MP0005023_abnormal_wound_healing0.87556544
82MP0002111_abnormal_tail_morphology0.86915721
83MP0003186_abnormal_redox_activity0.85967080
84MP0002089_abnormal_postnatal_growth/wei0.84870542
85MP0001216_abnormal_epidermal_layer0.84553042
86MP0003121_genomic_imprinting0.83355760
87MP0000653_abnormal_sex_gland0.82639433
88MP0001929_abnormal_gametogenesis0.82403861
89MP0005330_cardiomyopathy0.81336057
90MP0000762_abnormal_tongue_morphology0.81256809
91MP0002429_abnormal_blood_cell0.79704669
92MP0002163_abnormal_gland_morphology0.79645720
93MP0009278_abnormal_bone_marrow0.78861601
94MP0005621_abnormal_cell_physiology0.78826207
95MP0000537_abnormal_urethra_morphology0.77133527
96MP0001915_intracranial_hemorrhage0.76787194
97MP0005389_reproductive_system_phenotype0.76179368
98MP0001853_heart_inflammation0.75737560
99MP0002254_reproductive_system_inflammat0.75399797
100MP0004272_abnormal_basement_membrane0.73222390
101MP0005266_abnormal_metabolism0.71936309
102MP0003221_abnormal_cardiomyocyte_apopto0.71749532
103MP0005666_abnormal_adipose_tissue0.71672960
104MP0000747_muscle_weakness0.70664385
105MP0009672_abnormal_birth_weight0.69279277
106MP0000733_abnormal_muscle_development0.67209246
107MP0005623_abnormal_meninges_morphology0.66921376
108MP0009931_abnormal_skin_appearance0.66853415
109MP0000467_abnormal_esophagus_morphology0.66619783
110MP0000751_myopathy0.66467831
111MP0008438_abnormal_cutaneous_collagen0.66133415
112MP0003566_abnormal_cell_adhesion0.65053015
113MP0001119_abnormal_female_reproductive0.64975253
114MP0001243_abnormal_dermal_layer0.64967859
115MP0000371_diluted_coat_color0.64335730
116MP0009379_abnormal_foot_pigmentation0.63973663
117MP0000477_abnormal_intestine_morphology0.63805521
118MP0000716_abnormal_immune_system0.63593021
119MP0006036_abnormal_mitochondrial_physio0.63303711
120MP0002405_respiratory_system_inflammati0.63174218
121MP0000428_abnormal_craniofacial_morphol0.62128634
122MP0001727_abnormal_embryo_implantation0.61561983
123MP0002006_tumorigenesis0.61299803
124MP0002075_abnormal_coat/hair_pigmentati0.60736844
125MP0002092_abnormal_eye_morphology0.60398999
126MP0001849_ear_inflammation0.60335837
127MP0002269_muscular_atrophy0.60202518
128MP0003878_abnormal_ear_physiology0.59504067
129MP0005377_hearing/vestibular/ear_phenot0.59504067
130MP0005501_abnormal_skin_physiology0.57615830
131MP0003283_abnormal_digestive_organ0.57614591
132MP0008770_decreased_survivor_rate0.57318598
133MP0009053_abnormal_anal_canal0.55711332
134MP0001919_abnormal_reproductive_system0.53960431
135MP0008789_abnormal_olfactory_epithelium0.53188055
136MP0004264_abnormal_extraembryonic_tissu0.51872492
137MP0003937_abnormal_limbs/digits/tail_de0.51128424

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.80061810
2Microvesicular hepatic steatosis (HP:0001414)4.45102183
3Breast hypoplasia (HP:0003187)4.30926212
4Reticulocytopenia (HP:0001896)3.97251565
5Abnormality of cells of the erythroid lineage (HP:0012130)3.90225738
6Rough bone trabeculation (HP:0100670)3.78577589
7Abnormal number of erythroid precursors (HP:0012131)3.78508584
8Oral leukoplakia (HP:0002745)3.74820315
9Selective tooth agenesis (HP:0001592)3.66824572
10Cerebral hypomyelination (HP:0006808)3.58099112
11Ependymoma (HP:0002888)3.46370301
12Patellar aplasia (HP:0006443)3.41664467
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40485881
14Chromsome breakage (HP:0040012)3.27315028
15Aplasia/Hypoplasia of the patella (HP:0006498)3.20776369
16Degeneration of anterior horn cells (HP:0002398)3.18388524
17Abnormality of the anterior horn cell (HP:0006802)3.18388524
18Carpal bone hypoplasia (HP:0001498)3.15342584
19Absent radius (HP:0003974)3.15267765
20Ragged-red muscle fibers (HP:0003200)3.15121486
21Abnormality of glycolysis (HP:0004366)3.14480308
22Colon cancer (HP:0003003)2.98923111
23Absent thumb (HP:0009777)2.98489310
24Multiple enchondromatosis (HP:0005701)2.95017143
25Trismus (HP:0000211)2.94394581
26Aplasia involving forearm bones (HP:0009822)2.93045427
27Absent forearm bone (HP:0003953)2.93045427
28Meckel diverticulum (HP:0002245)2.91941323
29Medulloblastoma (HP:0002885)2.90412170
30Aplastic anemia (HP:0001915)2.88166775
31Abnormality of the preputium (HP:0100587)2.86821931
32Abnormal gallbladder physiology (HP:0012438)2.86609320
33Cholecystitis (HP:0001082)2.86609320
34Abnormality of the ileum (HP:0001549)2.85447593
35Microretrognathia (HP:0000308)2.84310584
36Increased serum pyruvate (HP:0003542)2.78501971
37Premature graying of hair (HP:0002216)2.76843638
38Abnormality of the labia minora (HP:0012880)2.75340208
39Agnosia (HP:0010524)2.73507309
40Abnormal trabecular bone morphology (HP:0100671)2.70425720
41Progressive external ophthalmoplegia (HP:0000590)2.69936046
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.68528480
43Pallor (HP:0000980)2.67019002
44Abnormality of chromosome stability (HP:0003220)2.65793590
45Macrocytic anemia (HP:0001972)2.64337666
46Type I transferrin isoform profile (HP:0003642)2.58017324
47Hyperacusis (HP:0010780)2.57277710
48Myelodysplasia (HP:0002863)2.57236815
49Abnormal number of incisors (HP:0011064)2.57089787
50Neoplasm of the pancreas (HP:0002894)2.56469685
51Premature ovarian failure (HP:0008209)2.56294888
52Bone marrow hypocellularity (HP:0005528)2.51783909
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49732951
54Achilles tendon contracture (HP:0001771)2.46638473
55Impulsivity (HP:0100710)2.42595798
56Supernumerary spleens (HP:0009799)2.41324916
57Rhabdomyosarcoma (HP:0002859)2.38293478
58Aplasia/hypoplasia of the humerus (HP:0006507)2.36592933
59Progressive muscle weakness (HP:0003323)2.34466840
60Tracheoesophageal fistula (HP:0002575)2.33214677
61Cellular immunodeficiency (HP:0005374)2.32450470
62Glossoptosis (HP:0000162)2.31018793
63Small intestinal stenosis (HP:0012848)2.29938805
64Duodenal stenosis (HP:0100867)2.29938805
65Prominent nose (HP:0000448)2.28731531
66Facial hemangioma (HP:0000329)2.26899942
67Hypokinesia (HP:0002375)2.26243207
68Testicular atrophy (HP:0000029)2.24470234
69Basal cell carcinoma (HP:0002671)2.23553177
70Vertebral compression fractures (HP:0002953)2.22283492
71Premature rupture of membranes (HP:0001788)2.20781627
72Glioma (HP:0009733)2.20586450
7311 pairs of ribs (HP:0000878)2.20276077
74Spastic diplegia (HP:0001264)2.18206463
75Neoplasm of the oral cavity (HP:0100649)2.18160862
76Squamous cell carcinoma (HP:0002860)2.17007724
77Abnormal glycosylation (HP:0012345)2.16769029
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16769029
79Abnormal protein N-linked glycosylation (HP:0012347)2.16769029
80Abnormal protein glycosylation (HP:0012346)2.16769029
81Astrocytoma (HP:0009592)2.16495448
82Abnormality of the astrocytes (HP:0100707)2.16495448
83Secondary amenorrhea (HP:0000869)2.14908416
84Insomnia (HP:0100785)2.14626947
85Sloping forehead (HP:0000340)2.14511331
86Duplicated collecting system (HP:0000081)2.14060349
87Hypergonadotropic hypogonadism (HP:0000815)2.13784621
88Proximal placement of thumb (HP:0009623)2.13485583
89Cleft eyelid (HP:0000625)2.12322190
90Increased serum lactate (HP:0002151)2.12077343
91Deviation of the thumb (HP:0009603)2.11644894
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10408116
93Lymphoma (HP:0002665)2.09241958
94Abnormality of the Achilles tendon (HP:0005109)2.08295208
95Reduced antithrombin III activity (HP:0001976)2.08274643
96Atresia of the external auditory canal (HP:0000413)2.06558980
97Broad distal phalanx of finger (HP:0009836)2.05945227
98Horseshoe kidney (HP:0000085)2.05866318
99Asplenia (HP:0001746)2.04399372
100Atrophy/Degeneration involving motor neurons (HP:0007373)2.03925479
101Missing ribs (HP:0000921)2.01131004
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01098953
103Pancytopenia (HP:0001876)1.99488799
104Hepatocellular necrosis (HP:0001404)1.99011563
105Abnormalities of placenta or umbilical cord (HP:0001194)1.98585219
106Hypertensive crisis (HP:0100735)1.98552561
107CNS hypomyelination (HP:0003429)1.98231843
108Increased intramyocellular lipid droplets (HP:0012240)1.97816775
109Abnormality of the fetal cardiovascular system (HP:0010948)1.96882316
110Abnormal umbilical cord blood vessels (HP:0011403)1.96882316
111Single umbilical artery (HP:0001195)1.96882316
112Abnormal mitochondria in muscle tissue (HP:0008316)1.96836687
113Triphalangeal thumb (HP:0001199)1.96352781
114Rib fusion (HP:0000902)1.93816737
115Spinal muscular atrophy (HP:0007269)1.93013210
116Sparse eyelashes (HP:0000653)1.92951835
117Short thumb (HP:0009778)1.92930649
118Exercise intolerance (HP:0003546)1.92591230
119Abdominal situs inversus (HP:0003363)1.92296163
120Abnormality of abdominal situs (HP:0011620)1.92296163
121Shoulder girdle muscle weakness (HP:0003547)1.91671407
122Cafe-au-lait spot (HP:0000957)1.91144524
123Orthostatic hypotension (HP:0001278)1.90867701
124Abnormality of the duodenum (HP:0002246)1.90851793
125Upper limb muscle weakness (HP:0003484)1.90496568
126Short humerus (HP:0005792)1.90259073
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.90188605
128Amaurosis fugax (HP:0100576)1.87364017
129Ureteral duplication (HP:0000073)1.87171155
130Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86454648
131Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86454648
132Personality changes (HP:0000751)1.86453817
133Abnormality of the umbilical cord (HP:0010881)1.86070790
134Megaloblastic anemia (HP:0001889)1.85976045
135Abnormal lung lobation (HP:0002101)1.85346293
136Generalized amyotrophy (HP:0003700)1.84671604
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.83041416
138Ectopic kidney (HP:0000086)1.82627371
139Acute encephalopathy (HP:0006846)1.81805116
140Abnormality of DNA repair (HP:0003254)1.80833934
141Long palpebral fissure (HP:0000637)1.80190561
142Increased muscle lipid content (HP:0009058)1.79785891
143Increased connective tissue (HP:0009025)1.79669767
144Increased CSF lactate (HP:0002490)1.79665313
145Slender long bone (HP:0003100)1.79566800
146Nonimmune hydrops fetalis (HP:0001790)1.79182405
147Increased nuchal translucency (HP:0010880)1.79104808
148Abnormality of the renal collecting system (HP:0004742)1.78844595
149Breech presentation (HP:0001623)1.77841527
150Lactic acidosis (HP:0003128)1.77467577
151Abnormality of reticulocytes (HP:0004312)1.77273202
152Increased hepatocellular lipid droplets (HP:0006565)1.77174767
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77165041
154Facial cleft (HP:0002006)1.76907407
155Abnormality of the carotid arteries (HP:0005344)1.74966439
156Neoplasm of striated muscle (HP:0009728)1.74547723
157Reticulocytosis (HP:0001923)1.73868981
158Entropion (HP:0000621)1.72873801
159Acute necrotizing encephalopathy (HP:0006965)1.72742668
160Overriding aorta (HP:0002623)1.71876159
161Truncus arteriosus (HP:0001660)1.71583278
162Mitochondrial inheritance (HP:0001427)1.70494547
163Reduced subcutaneous adipose tissue (HP:0003758)1.69040968
164Pelvic girdle muscle weakness (HP:0003749)1.67029471
165Biconcave vertebral bodies (HP:0004586)1.65208877
166Premature skin wrinkling (HP:0100678)1.64627005
167Myopathic facies (HP:0002058)1.64198225
168Respiratory difficulties (HP:0002880)1.62713134
169Redundant skin (HP:0001582)1.62048982
170Elbow flexion contracture (HP:0002987)1.61321391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.05431862
2VRK24.53988223
3WEE13.99732823
4SMG13.70231580
5CDC73.50375314
6EIF2AK12.91548678
7TSSK62.68626035
8TTK2.65554117
9EPHA22.47063163
10NEK22.42439611
11PBK2.35739705
12SRPK12.27505512
13NME22.27421820
14TESK22.13115773
15NEK12.04947208
16PLK42.02366456
17PLK11.97315693
18CDK71.88580282
19RPS6KB21.86715034
20STK161.84597256
21CDK121.78945220
22EIF2AK31.74029820
23PIM21.71518393
24ZAK1.67438262
25TRIB31.62903874
26ARAF1.60937794
27EEF2K1.59252382
28ATR1.58276386
29VRK11.58186759
30DYRK31.53572587
31AURKB1.53314479
32ACVR1B1.48673587
33STK101.47279932
34TLK11.47077887
35CHEK21.46675623
36MAP3K81.43308517
37BRSK21.41340227
38AURKA1.40390457
39CDK41.38311135
40RPS6KA41.36537328
41TAF11.36257680
42PLK31.29070730
43PASK1.28867081
44CHEK11.28671246
45MAP4K11.28666887
46MAP3K111.14173304
47AKT31.14044194
48ERN11.11605410
49ICK1.11445530
50PIM11.11004403
51PRPF4B1.09763190
52MKNK11.09517859
53SCYL21.07900776
54PAK41.07416591
55MST1R1.06659338
56BRSK10.98561667
57MAPKAPK30.98529215
58STK40.94462641
59LATS20.93682666
60BRAF0.92976889
61TAOK20.90586785
62CDK20.86408995
63MKNK20.85782785
64LMTK20.85720291
65KDR0.84392054
66ALK0.83361271
67LIMK10.82867907
68MST40.81814214
69PAK10.80845917
70MAP2K30.80419491
71ATM0.77423699
72MAP3K100.77220329
73PRKCI0.76130236
74SIK10.75660924
75CSNK2A20.74396149
76FLT30.73578960
77ILK0.73523909
78PNCK0.72045306
79TESK10.69168059
80TTN0.69060817
81TGFBR10.66242707
82ERBB40.65383280
83CSNK2A10.63335869
84DAPK30.60775568
85ZAP700.60640751
86BMX0.57914608
87MAPK110.57693720
88LRRK20.57687858
89BCKDK0.56412988
90CCNB10.56237338
91EIF2AK20.55920959
92RPS6KA50.55872586
93ABL20.55437466
94CDK10.55041652
95MTOR0.54397345
96NME10.54357423
97STK38L0.54150665
98RAF10.53321161
99GRK60.51813917
100CDK90.51556684
101AKT20.50701302
102CSNK1G30.46108770
103CSNK1E0.44846038
104PKN20.44334398
105BRD40.42779328
106CDK60.41158148
107CDK80.41125500
108MAP3K30.40794248
109MAP2K20.40579944
110PDK20.40104531
111CLK10.38957092
112PINK10.38818541
113PAK20.37867416
114DYRK20.34507202
115STK30.33744412
116MELK0.32823794
117JAK30.32203686
118IKBKB0.31709526
119IRAK30.31283600
120TBK10.31124982
121MET0.30211384
122IRAK20.29615834
123PTK20.28798764
124MOS0.27803231
125CHUK0.27607498
126PRKDC0.27260851
127DAPK10.25127849
128TXK0.24222471
129MAPKAPK20.21227649
130RPS6KA10.20735194

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70371771
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.17528693
3Mismatch repair_Homo sapiens_hsa034304.02583870
4RNA polymerase_Homo sapiens_hsa030203.82074278
5Ribosome_Homo sapiens_hsa030103.39745697
6Spliceosome_Homo sapiens_hsa030403.35883905
7RNA transport_Homo sapiens_hsa030133.22877077
8Proteasome_Homo sapiens_hsa030503.18232846
9Base excision repair_Homo sapiens_hsa034103.06024978
10One carbon pool by folate_Homo sapiens_hsa006702.84788227
11Homologous recombination_Homo sapiens_hsa034402.81524957
12Nucleotide excision repair_Homo sapiens_hsa034202.76105359
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70244119
14Pyrimidine metabolism_Homo sapiens_hsa002402.65045515
15Cell cycle_Homo sapiens_hsa041102.42652603
16Fanconi anemia pathway_Homo sapiens_hsa034602.14694571
17RNA degradation_Homo sapiens_hsa030181.79555361
18Basal transcription factors_Homo sapiens_hsa030221.71943036
19mRNA surveillance pathway_Homo sapiens_hsa030151.70497262
20Non-homologous end-joining_Homo sapiens_hsa034501.69117237
21p53 signaling pathway_Homo sapiens_hsa041151.66443265
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43140413
23Purine metabolism_Homo sapiens_hsa002301.39879979
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29058459
25Epstein-Barr virus infection_Homo sapiens_hsa051691.25595599
26Vitamin B6 metabolism_Homo sapiens_hsa007501.22604116
27Fatty acid elongation_Homo sapiens_hsa000621.21527032
28Biosynthesis of amino acids_Homo sapiens_hsa012301.11542545
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.11271213
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.08610843
31Folate biosynthesis_Homo sapiens_hsa007901.08575977
32Pyruvate metabolism_Homo sapiens_hsa006201.06984273
33Systemic lupus erythematosus_Homo sapiens_hsa053221.04920097
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04837428
35Pentose phosphate pathway_Homo sapiens_hsa000301.03183515
36Sulfur relay system_Homo sapiens_hsa041221.02889636
37Viral carcinogenesis_Homo sapiens_hsa052030.92203716
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92011807
39Oxidative phosphorylation_Homo sapiens_hsa001900.89738416
40Herpes simplex infection_Homo sapiens_hsa051680.88854296
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.85339026
42Antigen processing and presentation_Homo sapiens_hsa046120.76265893
43Selenocompound metabolism_Homo sapiens_hsa004500.74445082
44HTLV-I infection_Homo sapiens_hsa051660.71669005
45Oocyte meiosis_Homo sapiens_hsa041140.70259006
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70038417
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68313930
48Fructose and mannose metabolism_Homo sapiens_hsa000510.67192284
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65797280
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61370695
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60267904
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58661377
53Thyroid cancer_Homo sapiens_hsa052160.58392908
54Primary immunodeficiency_Homo sapiens_hsa053400.57238838
55Carbon metabolism_Homo sapiens_hsa012000.54045382
56Small cell lung cancer_Homo sapiens_hsa052220.53410693
57Legionellosis_Homo sapiens_hsa051340.52449862
58Glutathione metabolism_Homo sapiens_hsa004800.49888904
59Apoptosis_Homo sapiens_hsa042100.48760481
60Huntingtons disease_Homo sapiens_hsa050160.48308883
61MicroRNAs in cancer_Homo sapiens_hsa052060.47694024
62Vibrio cholerae infection_Homo sapiens_hsa051100.47019416
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46891402
64Alzheimers disease_Homo sapiens_hsa050100.45882207
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42974694
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42280878
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42096994
68Sulfur metabolism_Homo sapiens_hsa009200.41942456
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.41861373
70Phenylalanine metabolism_Homo sapiens_hsa003600.41763137
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41743976
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41318037
73Steroid biosynthesis_Homo sapiens_hsa001000.41286419
74Hippo signaling pathway_Homo sapiens_hsa043900.41198101
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38729171
76Bladder cancer_Homo sapiens_hsa052190.37954933
77Measles_Homo sapiens_hsa051620.37798769
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37143658
79Other glycan degradation_Homo sapiens_hsa005110.36544700
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34186466
81Acute myeloid leukemia_Homo sapiens_hsa052210.33493012
82Shigellosis_Homo sapiens_hsa051310.33022603
83TGF-beta signaling pathway_Homo sapiens_hsa043500.32893131
84Galactose metabolism_Homo sapiens_hsa000520.32455463
85HIF-1 signaling pathway_Homo sapiens_hsa040660.32380247
86Pancreatic cancer_Homo sapiens_hsa052120.32325066
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31990648
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29625124
89Alcoholism_Homo sapiens_hsa050340.28419835
90Fatty acid metabolism_Homo sapiens_hsa012120.28005358
91Notch signaling pathway_Homo sapiens_hsa043300.27640148
92Colorectal cancer_Homo sapiens_hsa052100.27033583
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.26847412
94Basal cell carcinoma_Homo sapiens_hsa052170.26777287
95Hepatitis B_Homo sapiens_hsa051610.26327648
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25323455
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24158873
98Non-small cell lung cancer_Homo sapiens_hsa052230.23684095
99Arginine biosynthesis_Homo sapiens_hsa002200.23398425
100Metabolic pathways_Homo sapiens_hsa011000.23025931
101Arginine and proline metabolism_Homo sapiens_hsa003300.21725491
102Parkinsons disease_Homo sapiens_hsa050120.21295635
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20037800
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19851647
105Lysine degradation_Homo sapiens_hsa003100.19236889
106Chronic myeloid leukemia_Homo sapiens_hsa052200.18383683
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18368046
108Prion diseases_Homo sapiens_hsa050200.17407208
109Influenza A_Homo sapiens_hsa051640.16809124
110Pathways in cancer_Homo sapiens_hsa052000.16472341
111N-Glycan biosynthesis_Homo sapiens_hsa005100.16415543
112mTOR signaling pathway_Homo sapiens_hsa041500.15840388
113Allograft rejection_Homo sapiens_hsa053300.15466626
114Hematopoietic cell lineage_Homo sapiens_hsa046400.14940626
115Protein export_Homo sapiens_hsa030600.14672121
116Asthma_Homo sapiens_hsa053100.14558752
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13719070
118Hedgehog signaling pathway_Homo sapiens_hsa043400.12310752
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11972598
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.10968211
121Viral myocarditis_Homo sapiens_hsa054160.10765079
122Regulation of autophagy_Homo sapiens_hsa041400.09442393
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09251895
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08071872
125Arachidonic acid metabolism_Homo sapiens_hsa005900.06339086

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