RS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)9.93005362
2positive regulation of guanylate cyclase activity (GO:0031284)9.28966706
3* visual perception (GO:0007601)8.70082447
4* sensory perception of light stimulus (GO:0050953)8.60213265
5regulation of guanylate cyclase activity (GO:0031282)8.38160186
6cellular response to light stimulus (GO:0071482)7.63016414
7photoreceptor cell differentiation (GO:0046530)7.30068984
8eye photoreceptor cell differentiation (GO:0001754)7.30068984
9detection of external stimulus (GO:0009581)7.14629911
10detection of abiotic stimulus (GO:0009582)7.01152850
11retina development in camera-type eye (GO:0060041)6.57026810
12regulation of cGMP metabolic process (GO:0030823)6.07285842
13positive regulation of cGMP biosynthetic process (GO:0030828)5.48384254
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.45434510
15regulation of cGMP biosynthetic process (GO:0030826)5.14034850
16cellular response to radiation (GO:0071478)4.95946197
17positive regulation of cGMP metabolic process (GO:0030825)4.84253715
18nonmotile primary cilium assembly (GO:0035058)4.80870912
19detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.70402471
20cell morphogenesis involved in neuron differentiation (GO:0048667)4.58384918
21receptor guanylyl cyclase signaling pathway (GO:0007168)4.51030886
22regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.44446882
23neuronal action potential propagation (GO:0019227)4.34624551
24neuron fate determination (GO:0048664)4.32802729
25behavioral response to nicotine (GO:0035095)4.32750268
26estrogen biosynthetic process (GO:0006703)4.23295923
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17944074
28neurotransmitter-gated ion channel clustering (GO:0072578)4.15693776
29regulation of clathrin-mediated endocytosis (GO:2000369)4.12212094
30* sensory perception (GO:0007600)4.11066002
31primitive streak formation (GO:0090009)3.93744521
32pyrimidine nucleobase catabolic process (GO:0006208)3.92581445
33response to light stimulus (GO:0009416)3.91097060
34neurofilament cytoskeleton organization (GO:0060052)3.90356380
35prenylation (GO:0097354)3.88908654
36protein prenylation (GO:0018342)3.88908654
37cerebral cortex radially oriented cell migration (GO:0021799)3.88055951
38regulation of voltage-gated calcium channel activity (GO:1901385)3.82766114
39neuron development (GO:0048666)3.71635660
40* adaptation of signaling pathway (GO:0023058)3.71022924
41tongue development (GO:0043586)3.67201823
42positive regulation of gastrulation (GO:2000543)3.65633052
43synaptic transmission, cholinergic (GO:0007271)3.62525881
44somite rostral/caudal axis specification (GO:0032525)3.59397496
45regulation of feeding behavior (GO:0060259)3.57338590
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.52874215
47tachykinin receptor signaling pathway (GO:0007217)3.44258636
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39929949
49piRNA metabolic process (GO:0034587)3.39900357
50protein localization to synapse (GO:0035418)3.39055995
51central nervous system projection neuron axonogenesis (GO:0021952)3.38833225
52response to dietary excess (GO:0002021)3.37471091
53negative regulation of receptor-mediated endocytosis (GO:0048261)3.34092126
54retina homeostasis (GO:0001895)3.32760331
55response to amphetamine (GO:0001975)3.31798968
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29186341
57regulation of dopamine metabolic process (GO:0042053)3.24937961
58regulation of catecholamine metabolic process (GO:0042069)3.24937961
59CDP-diacylglycerol biosynthetic process (GO:0016024)3.23717814
60hindbrain development (GO:0030902)3.19901442
61neuron recognition (GO:0008038)3.18558196
62short-term memory (GO:0007614)3.16238476
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15546471
64mitochondrion distribution (GO:0048311)3.13768676
65positive regulation of action potential (GO:0045760)3.11917021
66postsynaptic membrane organization (GO:0001941)3.11119657
67retinoid metabolic process (GO:0001523)3.10423550
68membrane hyperpolarization (GO:0060081)3.09817111
69axoneme assembly (GO:0035082)3.09443307
70presynaptic membrane assembly (GO:0097105)3.09226453
71exploration behavior (GO:0035640)3.07051213
72regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.06999286
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06969980
74sympathetic nervous system development (GO:0048485)3.06739223
75regulation of respiratory system process (GO:0044065)3.06130989
76positive regulation of neurotransmitter transport (GO:0051590)3.06059357
77glycine transport (GO:0015816)3.05369428
78central nervous system neuron axonogenesis (GO:0021955)3.05073459
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04501480
80behavioral response to ethanol (GO:0048149)3.03078592
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01763773
82regulation of collateral sprouting (GO:0048670)3.01629462
83nucleobase catabolic process (GO:0046113)3.00991933
84regulation of cellular respiration (GO:0043457)2.99552474
85cell migration in hindbrain (GO:0021535)2.98800602
86positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.96951254
87chemosensory behavior (GO:0007635)2.95853200
88positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.94876462
89regulation of penile erection (GO:0060405)2.94285117
90CDP-diacylglycerol metabolic process (GO:0046341)2.93069061
91dendrite morphogenesis (GO:0048813)2.89541442
92regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88896981
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88896981
94phospholipid translocation (GO:0045332)2.88741912
95lipid translocation (GO:0034204)2.88741912
96regulation of neurotransmitter uptake (GO:0051580)2.88568581
97regulation of DNA methylation (GO:0044030)2.87957902
98diterpenoid metabolic process (GO:0016101)2.87202244
99response to histamine (GO:0034776)2.86860645
100neuron-neuron synaptic transmission (GO:0007270)2.86486173
101serotonin metabolic process (GO:0042428)2.85988919
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.85712241
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82889017
104L-amino acid import (GO:0043092)2.81730050
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.81242917
106positive regulation of dendritic spine development (GO:0060999)2.80316388
107positive regulation of cell cycle G2/M phase transition (GO:1902751)2.80044348
108positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.80044348
109gamma-aminobutyric acid transport (GO:0015812)2.79455815
110specification of organ identity (GO:0010092)2.79263425
111positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.79180267
112dopamine biosynthetic process (GO:0042416)2.78773931
113negative regulation of appetite (GO:0032099)2.76593927
114negative regulation of response to food (GO:0032096)2.76593927
115positive regulation of sodium ion transmembrane transport (GO:1902307)2.76546559
116regulation of respiratory gaseous exchange (GO:0043576)2.76275229
117regulation of female gonad development (GO:2000194)2.75962171
118multicellular organism reproduction (GO:0032504)2.75728517
119detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.69878986
120axonal fasciculation (GO:0007413)2.69115468
121synaptic vesicle maturation (GO:0016188)2.68959223
122response to radiation (GO:0009314)2.68617153
123glycerophospholipid catabolic process (GO:0046475)2.68588306
124DNA methylation involved in gamete generation (GO:0043046)2.68467468
125dopaminergic neuron differentiation (GO:0071542)2.68170307
126negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66957223
127adult walking behavior (GO:0007628)2.66728836
128terpenoid metabolic process (GO:0006721)2.62898832
129response to cocaine (GO:0042220)2.62835249
130establishment of mitochondrion localization (GO:0051654)2.62027454
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60937337
132post-embryonic morphogenesis (GO:0009886)2.60442937
133glycosphingolipid biosynthetic process (GO:0006688)2.59933822
134positive regulation of ERBB signaling pathway (GO:1901186)2.59895814
135membrane depolarization during action potential (GO:0086010)2.59525165
136presynaptic membrane organization (GO:0097090)2.59358244
137detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58801197
138transmission of nerve impulse (GO:0019226)2.58265315
139negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.57144098
140glutamate receptor signaling pathway (GO:0007215)2.55466800
141positive regulation of synapse assembly (GO:0051965)2.55428957
142retinol metabolic process (GO:0042572)2.54674443
143icosanoid secretion (GO:0032309)2.52268161
144arachidonic acid secretion (GO:0050482)2.52268161
145regulation of meiosis I (GO:0060631)2.52171427
146cellular response to abiotic stimulus (GO:0071214)2.52070971
147axon extension (GO:0048675)2.51556233
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.51448770
149detection of chemical stimulus involved in sensory perception (GO:0050907)2.49974085
150lipoprotein transport (GO:0042953)2.42369661
151negative regulation of cation channel activity (GO:2001258)2.41742087
152dopamine receptor signaling pathway (GO:0007212)2.40362633
153righting reflex (GO:0060013)2.37821393
154negative regulation of calcium ion transmembrane transport (GO:1903170)2.36162122
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.36162122
156mitochondrion transport along microtubule (GO:0047497)2.35719139
157establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.35719139
158protein heterotetramerization (GO:0051290)2.33393414
159startle response (GO:0001964)2.31609632
160positive regulation of cyclase activity (GO:0031281)2.29221947
161behavioral response to cocaine (GO:0048148)2.27803864
162synaptic transmission, dopaminergic (GO:0001963)2.17795540
163cellular potassium ion homeostasis (GO:0030007)2.17213464
164regulation of rhodopsin mediated signaling pathway (GO:0022400)18.4907488
165rhodopsin mediated signaling pathway (GO:0016056)18.1072157
166retinal cone cell development (GO:0046549)15.2993487
167photoreceptor cell development (GO:0042461)12.4879677
168photoreceptor cell maintenance (GO:0045494)12.2089329
169eye photoreceptor cell development (GO:0042462)11.8648942
170detection of light stimulus involved in visual perception (GO:0050908)11.0541295
171detection of light stimulus involved in sensory perception (GO:0050962)11.0541295
172phototransduction (GO:0007602)10.7914250
173phototransduction, visible light (GO:0007603)10.7912160
174retinal rod cell development (GO:0046548)10.3199627
175detection of visible light (GO:0009584)10.2691289
176detection of light stimulus (GO:0009583)10.1963166
177GMP metabolic process (GO:0046037)10.1855308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22030599
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.48204282
3* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.45686180
4GBX2_23144817_ChIP-Seq_PC3_Human3.15474640
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79429163
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76754647
7VDR_22108803_ChIP-Seq_LS180_Human2.65409169
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.18394753
9DROSHA_22980978_ChIP-Seq_HELA_Human2.12577921
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08889728
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07199313
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06626817
13* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02809899
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.00458657
15EZH2_22144423_ChIP-Seq_EOC_Human10.1018347
16AR_21572438_ChIP-Seq_LNCaP_Human1.93688693
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92132110
18BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.84719476
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83920544
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82560292
21SMAD3_21741376_ChIP-Seq_HESCs_Human1.81955088
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80748843
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.68582129
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.66364413
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64085192
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63291667
27REST_21632747_ChIP-Seq_MESCs_Mouse1.63117708
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62026294
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61776650
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61466283
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61175123
32IGF1R_20145208_ChIP-Seq_DFB_Human1.58966418
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.55623949
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.55036654
35AR_19668381_ChIP-Seq_PC3_Human1.53616822
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.53591627
37TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.53289841
38RNF2_27304074_Chip-Seq_NSC_Mouse1.51024594
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49485908
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47960089
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47960089
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.44702505
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44414037
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.44336700
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43598445
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43547098
47TAF15_26573619_Chip-Seq_HEK293_Human1.43127481
48ZNF274_21170338_ChIP-Seq_K562_Hela1.40567703
49KDM2B_26808549_Chip-Seq_K562_Human1.38318338
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37170345
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37090030
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.35942190
53STAT3_23295773_ChIP-Seq_U87_Human1.35748860
54TBL1_22424771_ChIP-Seq_293T_Human1.35159962
55AR_25329375_ChIP-Seq_VCAP_Human1.33773995
56P300_19829295_ChIP-Seq_ESCs_Human1.33466839
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.33305751
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.33288573
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32506805
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.31432392
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.29187266
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26413894
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25733331
64BCAT_22108803_ChIP-Seq_LS180_Human1.25694039
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.25342963
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24450506
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23403871
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23225810
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.22782121
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22055729
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21478593
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.18590357
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17680609
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14081725
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13391090
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.12400528
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.11709204
78ER_23166858_ChIP-Seq_MCF-7_Human1.10217341
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.10073079
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09563336
81TCF4_23295773_ChIP-Seq_U87_Human1.08203254
82JUN_21703547_ChIP-Seq_K562_Human1.08157097
83SMAD4_21741376_ChIP-Seq_HESCs_Human1.06837892
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06092795
85EGR1_19032775_ChIP-ChIP_M12_Human1.06058545
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05456446
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05018811
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04677606
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04330407
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04148444
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03377126
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.03280514
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03133643
94WDR5_24793694_ChIP-Seq_LNCAP_Human1.02648423
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02309894
96CTCF_27219007_Chip-Seq_Bcells_Human1.02167377
97AHR_22903824_ChIP-Seq_MCF-7_Human1.01683094
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01321270
99CBP_20019798_ChIP-Seq_JUKART_Human1.01321270
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.00683427
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00409662
102IRF1_19129219_ChIP-ChIP_H3396_Human0.99854180
103EWS_26573619_Chip-Seq_HEK293_Human0.99623911
104NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.99223073
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98762240
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.98665999
107FUS_26573619_Chip-Seq_HEK293_Human0.97474666
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96029372
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95924084
110CBP_21632823_ChIP-Seq_H3396_Human0.95513055
111GF1_26923725_Chip-Seq_HPCs_Mouse0.95009965
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94547277
113SMC4_20622854_ChIP-Seq_HELA_Human0.94302638
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.94288713
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94220162
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.93469540
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.92924300
118TAF2_19829295_ChIP-Seq_ESCs_Human0.92787533
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92729952
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92399116
121* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92311848
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92120145
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91863666
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91457384
125DPY_21335234_ChIP-Seq_ESCs_Mouse0.91171066
126* OCT1_27270436_Chip-Seq_PROSTATE_Human0.90225499
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88714793
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88661874
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88541009
130CBX2_27304074_Chip-Seq_ESCs_Mouse0.88479102
131NCOR_22424771_ChIP-Seq_293T_Human0.87401437
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87398080
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87398080
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.87371291
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.87034282
136KDM2B_26808549_Chip-Seq_REH_Human0.86931526
137* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86470412
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.86173464
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86069616
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85093572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.56765451
2MP0005253_abnormal_eye_physiology6.97482683
3MP0006072_abnormal_retinal_apoptosis6.54945604
4MP0003950_abnormal_plasma_membrane3.93477448
5* MP0005195_abnormal_posterior_eye3.81980113
6MP0005391_vision/eye_phenotype3.39022362
7* MP0001324_abnormal_eye_pigmentation3.17961790
8MP0002090_abnormal_vision3.05517376
9MP0002638_abnormal_pupillary_reflex2.91410627
10MP0002229_neurodegeneration2.67422589
11MP0005423_abnormal_somatic_nervous2.49042272
12MP0008877_abnormal_DNA_methylation2.36547131
13MP0003879_abnormal_hair_cell2.22225245
14MP0002736_abnormal_nociception_after2.18201969
15MP0002234_abnormal_pharynx_morphology2.17914207
16MP0003787_abnormal_imprinting2.16003230
17MP0001764_abnormal_homeostasis2.14918055
18MP0003011_delayed_dark_adaptation11.3175331
19* MP0002752_abnormal_somatic_nervous1.89875454
20MP0003121_genomic_imprinting1.81405694
21MP0006276_abnormal_autonomic_nervous1.76443224
22MP0001986_abnormal_taste_sensitivity1.76233210
23MP0003122_maternal_imprinting1.67961439
24MP0002735_abnormal_chemical_nociception1.60328303
25MP0009379_abnormal_foot_pigmentation1.59665546
26MP0001188_hyperpigmentation1.58523179
27MP0003718_maternal_effect1.53876027
28MP0004133_heterotaxia1.51369446
29MP0002653_abnormal_ependyma_morphology1.47274105
30MP0004019_abnormal_vitamin_homeostasis1.43647638
31MP0002733_abnormal_thermal_nociception1.43406186
32MP0000955_abnormal_spinal_cord1.39747238
33* MP0002882_abnormal_neuron_morphology1.38137197
34MP0000049_abnormal_middle_ear1.36824497
35MP0001440_abnormal_grooming_behavior1.34340878
36MP0001502_abnormal_circadian_rhythm1.20008721
37MP0000569_abnormal_digit_pigmentation1.16134907
38MP0003942_abnormal_urinary_system1.15627547
39MP0003136_yellow_coat_color1.11360291
40MP0003123_paternal_imprinting1.09192386
41MP0001293_anophthalmia1.06106531
42MP0004233_abnormal_muscle_weight1.05168784
43MP0002876_abnormal_thyroid_physiology1.05090572
44MP0006292_abnormal_olfactory_placode1.04355899
45MP0004885_abnormal_endolymph1.03997022
46MP0001984_abnormal_olfaction1.03925322
47MP0001529_abnormal_vocalization1.03225367
48MP0003119_abnormal_digestive_system1.01653988
49MP0002837_dystrophic_cardiac_calcinosis1.00747574
50MP0004270_analgesia0.99578815
51MP0005197_abnormal_uvea_morphology0.97571101
52MP0002751_abnormal_autonomic_nervous0.97303607
53MP0001486_abnormal_startle_reflex0.94014293
54MP0001485_abnormal_pinna_reflex0.90013603
55MP0002233_abnormal_nose_morphology0.89133099
56MP0003861_abnormal_nervous_system0.88698153
57MP0003938_abnormal_ear_development0.87291553
58MP0002069_abnormal_eating/drinking_beha0.84643220
59MP0003634_abnormal_glial_cell0.82868425
60MP0010030_abnormal_orbit_morphology0.81778130
61MP0000427_abnormal_hair_cycle0.80295155
62MP0003755_abnormal_palate_morphology0.79600743
63MP0003880_abnormal_central_pattern0.78703035
64MP0005394_taste/olfaction_phenotype0.77615609
65MP0005499_abnormal_olfactory_system0.77615609
66MP0003385_abnormal_body_wall0.77267603
67MP0002332_abnormal_exercise_endurance0.74818285
68MP0002272_abnormal_nervous_system0.74586785
69MP0009250_abnormal_appendicular_skeleto0.73910454
70MP0002160_abnormal_reproductive_system0.73471038
71MP0002210_abnormal_sex_determination0.71758496
72MP0002127_abnormal_cardiovascular_syste0.70367508
73MP0001299_abnormal_eye_distance/0.66949144
74MP0000534_abnormal_ureter_morphology0.66638872
75MP0005187_abnormal_penis_morphology0.66115276
76MP0008789_abnormal_olfactory_epithelium0.63348901
77MP0004859_abnormal_synaptic_plasticity0.62395516
78MP0009046_muscle_twitch0.61559364
79MP0001286_abnormal_eye_development0.61214694
80MP0002064_seizures0.60840186
81MP0002734_abnormal_mechanical_nocicepti0.59015269
82MP0003635_abnormal_synaptic_transmissio0.56679119
83MP0001963_abnormal_hearing_physiology0.56326148
84MP0000465_gastrointestinal_hemorrhage0.49204741
85MP0002063_abnormal_learning/memory/cond0.46454420
86MP0005376_homeostasis/metabolism_phenot0.46182147
87MP0002067_abnormal_sensory_capabilities0.44619911
88MP0002572_abnormal_emotion/affect_behav0.43531654
89MP0001968_abnormal_touch/_nociception0.41815640
90MP0002102_abnormal_ear_morphology0.40231667
91MP0004742_abnormal_vestibular_system0.40191052
92MP0009745_abnormal_behavioral_response0.40171532
93MP0004924_abnormal_behavior0.39415463
94MP0005386_behavior/neurological_phenoty0.39415463
95MP0004215_abnormal_myocardial_fiber0.36020532
96MP0008004_abnormal_stomach_pH0.35261599
97MP0005248_abnormal_Harderian_gland0.34048015
98MP0010386_abnormal_urinary_bladder0.33798585
99MP0000631_abnormal_neuroendocrine_gland0.32941426
100MP0000026_abnormal_inner_ear0.32211837
101MP0003890_abnormal_embryonic-extraembry0.30745204
102MP0004782_abnormal_surfactant_physiolog0.30024967
103MP0009780_abnormal_chondrocyte_physiolo0.29266429
104MP0003045_fibrosis0.29114330
105MP0004085_abnormal_heartbeat0.27113491
106MP0008569_lethality_at_weaning0.26427642
107MP0004043_abnormal_pH_regulation0.25768669
108MP0002697_abnormal_eye_size0.25444733
109MP0002184_abnormal_innervation0.25319655
110MP0004142_abnormal_muscle_tone0.24923961
111MP0002066_abnormal_motor_capabilities/c0.24189224
112MP0002152_abnormal_brain_morphology0.23587429
113MP0005620_abnormal_muscle_contractility0.23368912
114MP0000778_abnormal_nervous_system0.23336969
115MP0004145_abnormal_muscle_electrophysio0.23326088
116MP0005646_abnormal_pituitary_gland0.22159105
117MP0005193_abnormal_anterior_eye0.20364779
118MP0001915_intracranial_hemorrhage0.20153590
119MP0003632_abnormal_nervous_system0.20111439
120MP0004811_abnormal_neuron_physiology0.18711235
121MP0005595_abnormal_vascular_smooth0.18338214
122MP0003633_abnormal_nervous_system0.16941097
123MP0001905_abnormal_dopamine_level0.16627194
124MP0003943_abnormal_hepatobiliary_system0.16395205
125MP0002928_abnormal_bile_duct0.16310260
126MP0002557_abnormal_social/conspecific_i0.15207279
127MP0003252_abnormal_bile_duct0.14451298
128MP0005076_abnormal_cell_differentiation0.14000831
129MP0001661_extended_life_span0.13966009
130MP0003631_nervous_system_phenotype0.13903557
131MP0003646_muscle_fatigue0.12835179
132MP0001501_abnormal_sleep_pattern0.12030991
133MP0002108_abnormal_muscle_morphology0.11844207
134MP0001970_abnormal_pain_threshold0.11616186
135MP0001177_atelectasis0.11258127
136MP0001879_abnormal_lymphatic_vessel0.08923364
137MP0000001_mammalian_phenotype0.08134744
138MP0002909_abnormal_adrenal_gland0.07918457
139MP0003638_abnormal_response/metabolism_0.07630636
140MP0003956_abnormal_body_size0.07481848
141MP0000749_muscle_degeneration0.07326229

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)8.99131853
2Chorioretinal atrophy (HP:0000533)8.95111618
3Dyschromatopsia (HP:0007641)8.69145616
4Central scotoma (HP:0000603)8.61731505
5Pendular nystagmus (HP:0012043)7.97293673
6Abnormality of macular pigmentation (HP:0008002)7.89127270
7Scotoma (HP:0000575)7.76996030
8Attenuation of retinal blood vessels (HP:0007843)7.62467604
9Abolished electroretinogram (ERG) (HP:0000550)7.09951078
10Decreased central vision (HP:0007663)6.39309876
11Photophobia (HP:0000613)5.72088048
12Type II diabetes mellitus (HP:0005978)5.67866328
13Vitreoretinal degeneration (HP:0000655)5.29298221
14Macular degeneration (HP:0000608)5.16282714
15Keratoconus (HP:0000563)5.11737696
16Increased corneal curvature (HP:0100692)5.11737696
17Myokymia (HP:0002411)5.11406387
18Cone-rod dystrophy (HP:0000548)5.05860437
19Posterior subcapsular cataract (HP:0007787)4.85517234
20Severe visual impairment (HP:0001141)4.79595806
21Constricted visual fields (HP:0001133)4.66134117
22Choroideremia (HP:0001139)4.61228821
23Retinitis pigmentosa (HP:0000510)4.46211836
24Limb dystonia (HP:0002451)4.34390780
25Focal motor seizures (HP:0011153)4.22517531
26Focal seizures (HP:0007359)4.15978011
27Shawl scrotum (HP:0000049)3.83984312
28Hyperventilation (HP:0002883)3.82206114
29Decreased electroretinogram (ERG) amplitude (HP:0000654)3.80559527
30Septo-optic dysplasia (HP:0100842)3.58803041
31Drooling (HP:0002307)3.36408217
32Poor eye contact (HP:0000817)3.25584534
33Abnormality of abdominal situs (HP:0011620)3.13886497
34Abdominal situs inversus (HP:0003363)3.13886497
35Excessive salivation (HP:0003781)3.08811669
36Action tremor (HP:0002345)3.02208655
37Subcapsular cataract (HP:0000523)2.97970585
38Bilateral microphthalmos (HP:0007633)2.87058656
39Protruding tongue (HP:0010808)2.77838568
40Congenital sensorineural hearing impairment (HP:0008527)2.74638267
41Amblyopia (HP:0000646)2.73896581
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.73016500
43High anterior hairline (HP:0009890)2.64054189
44Tented upper lip vermilion (HP:0010804)2.60998993
45Optic disc pallor (HP:0000543)2.59211244
46Wide nasal bridge (HP:0000431)2.54452408
47Abnormal eating behavior (HP:0100738)2.54208222
48Annular pancreas (HP:0001734)2.53714119
49Impaired social interactions (HP:0000735)2.53017496
50Abnormal social behavior (HP:0012433)2.53017496
51Abnormal hair whorl (HP:0010721)2.46838583
52Fair hair (HP:0002286)2.44436952
53Hemiparesis (HP:0001269)2.41654243
54Hepatoblastoma (HP:0002884)2.41342920
55* Progressive visual loss (HP:0000529)2.41259468
56Dialeptic seizures (HP:0011146)2.34505778
57Gait imbalance (HP:0002141)2.32322387
58Tubular atrophy (HP:0000092)2.31851158
59Congenital primary aphakia (HP:0007707)2.30338564
60Abnormality of the renal medulla (HP:0100957)2.25855688
61Epileptiform EEG discharges (HP:0011182)2.23618788
62Abnormal ciliary motility (HP:0012262)2.22752232
63Abnormality of the labia minora (HP:0012880)2.19889209
64Atonic seizures (HP:0010819)2.19500041
65Hypsarrhythmia (HP:0002521)2.17608248
66Absent septum pellucidum (HP:0001331)2.17250819
67Optic nerve hypoplasia (HP:0000609)2.15463243
68EEG with generalized epileptiform discharges (HP:0011198)2.14934521
69Exotropia (HP:0000577)2.13958906
70Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.10397528
71Generalized tonic-clonic seizures (HP:0002069)2.10397490
72Nephrogenic diabetes insipidus (HP:0009806)2.05635013
73Osteomalacia (HP:0002749)2.04199270
74Pachygyria (HP:0001302)2.03359296
75Fetal akinesia sequence (HP:0001989)2.03322903
76Poor suck (HP:0002033)2.00851067
77Congenital stationary night blindness (HP:0007642)14.0844152
78Bony spicule pigmentary retinopathy (HP:0007737)12.0313547
79Absent rod-and cone-mediated responses on ERG (HP:0007688)10.7652085
80Abnormal rod and cone electroretinograms (HP:0008323)10.2344483
81Medial flaring of the eyebrow (HP:0010747)1.96762154
82Absent speech (HP:0001344)1.92639218
83Esotropia (HP:0000565)1.92236921
84Abnormality of the renal cortex (HP:0011035)1.92096581
85Absence seizures (HP:0002121)1.88658117
86Maternal diabetes (HP:0009800)1.87239404
87Acute lymphatic leukemia (HP:0006721)1.85494766
88Palpebral edema (HP:0100540)1.83145233
89Lissencephaly (HP:0001339)1.83116343
90Impulsivity (HP:0100710)1.81808313
91Polyphagia (HP:0002591)1.77481057
92Hyperthyroidism (HP:0000836)1.77480078
93Poor coordination (HP:0002370)1.77157541
94Gastroesophageal reflux (HP:0002020)1.75890965
95Papillary thyroid carcinoma (HP:0002895)1.73208961
96Torticollis (HP:0000473)1.72917779
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72676502
98Abnormality of the septum pellucidum (HP:0007375)1.72118155
99Retinal dysplasia (HP:0007973)1.71811922
100Abnormality of cells of the erythroid lineage (HP:0012130)1.71168361
101Inappropriate behavior (HP:0000719)1.70989387
102Sensory axonal neuropathy (HP:0003390)1.70318552
103Hypoventilation (HP:0002791)1.67193391
104Abnormal drinking behavior (HP:0030082)1.65948025
105Polydipsia (HP:0001959)1.65948025
106Polar cataract (HP:0010696)1.65690869
107Generalized hypopigmentation of hair (HP:0011358)1.65261854
108Abnormal respiratory motile cilium physiology (HP:0012261)1.64129109
109Narrow forehead (HP:0000341)1.64098588
110Thyroid-stimulating hormone excess (HP:0002925)1.63967159
111Horizontal nystagmus (HP:0000666)1.63637684
112Optic atrophy (HP:0000648)1.62588328
113CNS hypomyelination (HP:0003429)1.62107011
114Vaginal atresia (HP:0000148)1.60907230
115Interstitial pulmonary disease (HP:0006530)1.57828258
116Genital tract atresia (HP:0001827)1.54870703
117Severe Myopia (HP:0011003)1.46796377
118True hermaphroditism (HP:0010459)1.45946867
119Pancreatic fibrosis (HP:0100732)1.42939704
120Aplasia/Hypoplasia of the lens (HP:0008063)1.36873824
121Dysdiadochokinesis (HP:0002075)1.32355104
122Abnormality of the fovea (HP:0000493)1.25791480
123Epileptic encephalopathy (HP:0200134)1.24306389
124Hypoplasia of the fovea (HP:0007750)1.20407503
125Aplasia/Hypoplasia of the fovea (HP:0008060)1.20407503
126Astigmatism (HP:0000483)1.15572391
127Febrile seizures (HP:0002373)1.15442452
128Pancreatic cysts (HP:0001737)1.12943962
129Cystic liver disease (HP:0006706)1.12177303
130Progressive cerebellar ataxia (HP:0002073)1.01609804
131Recurrent sinusitis (HP:0011108)1.01392896
132Aplasia/Hypoplasia of the tongue (HP:0010295)0.97409203
133Truncal ataxia (HP:0002078)0.96415531
134Specific learning disability (HP:0001328)0.93152495
135Aplasia/Hypoplasia of the macula (HP:0008059)0.92826120
136Left ventricular hypertrophy (HP:0001712)0.92447916
137Broad foot (HP:0001769)0.92017456
138Sclerocornea (HP:0000647)0.90105499
139Visual hallucinations (HP:0002367)0.89942582
140Hypermetropia (HP:0000540)0.87920822
141Asthma (HP:0002099)0.87554642
142Aplasia/Hypoplasia affecting the retina (HP:0008061)0.85333036
143Decreased testicular size (HP:0008734)0.84011901
144Genetic anticipation (HP:0003743)0.82630197
145Molar tooth sign on MRI (HP:0002419)0.80905995
146Abnormality of midbrain morphology (HP:0002418)0.80905995
147Furrowed tongue (HP:0000221)0.79619120
148Prolonged QT interval (HP:0001657)0.77843554
149* Retinal detachment (HP:0000541)0.76764148
150Cerebellar dysplasia (HP:0007033)0.75517205
151Abnormality of dental color (HP:0011073)0.72205120
152Anencephaly (HP:0002323)0.71057470
153Broad-based gait (HP:0002136)0.70720900
154Chronic hepatic failure (HP:0100626)0.69315052
155Congenital hepatic fibrosis (HP:0002612)0.68369118
156Postaxial hand polydactyly (HP:0001162)0.67843547
157Lymphopenia (HP:0001888)0.66467793
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.66079258
159Dental crowding (HP:0000678)0.65777704
160Hypodontia (HP:0000668)0.65744348
161Short foot (HP:0001773)0.64730973
162Abnormality of the fingertips (HP:0001211)0.63495909
163Corneal dystrophy (HP:0001131)0.62604316
164Gaze-evoked nystagmus (HP:0000640)0.61703929
165Abnormal EKG (HP:0003115)0.60611245
166Abnormality of cells of the lymphoid lineage (HP:0012140)0.59743677
167Generalized myoclonic seizures (HP:0002123)0.59259883
168Nephronophthisis (HP:0000090)0.59158075
169Postaxial foot polydactyly (HP:0001830)0.59149250
170Partial agenesis of the corpus callosum (HP:0001338)0.58891657
171Macroorchidism (HP:0000053)0.57006726
172Syncope (HP:0001279)0.56897107
173Aqueductal stenosis (HP:0002410)0.56851646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.08415447
2WNK34.47541403
3PINK13.21027474
4MAP3K93.06492405
5TNIK2.85533279
6IRAK22.42578650
7TRIM282.12483841
8GRK111.8005184
9DYRK21.89365281
10CDK191.87498733
11SIK21.70807742
12ADRBK11.55570619
13BMPR1B1.54520123
14CAMK1G1.53217335
15EPHA41.52583729
16CSNK1G31.46496621
17CSNK1G21.45041518
18MAP3K101.38594186
19MAPK121.37413779
20TAOK21.37382401
21MAPK71.37198401
22BRAF1.36585349
23INSRR1.31376239
24CAMK1D1.31069570
25BRD41.29203733
26HIPK21.26140934
27CDK121.25157912
28SGK4941.23943770
29SGK2231.23943770
30CSNK1G11.23425304
31ARAF1.21374169
32MARK11.20140965
33DMPK1.19708789
34MAP3K41.18480609
35PTK2B1.17442927
36PAK31.17257154
37SGK21.12613374
38CSNK1A1L1.12222697
39CSNK1D1.12072357
40AKT31.10488526
41TAOK31.09446599
42PAK61.07991481
43PNCK1.07305719
44KSR11.04542413
45PRKD31.03184673
46PRKCH1.02622851
47STK381.01954890
48OXSR10.99568423
49ERBB20.93813975
50SGK30.92619034
51RPS6KA40.91107337
52WNK10.88718010
53PRKCZ0.87331786
54CDK150.82854914
55STK160.82102118
56LATS20.81944200
57TYRO30.81591466
58CDK180.80528756
59ICK0.80471970
60CAMKK10.78621050
61DYRK1A0.77025154
62PRKCE0.76237252
63CDK11A0.75897874
64CDK140.75207100
65PRKCB0.73484287
66PLK20.72863224
67LATS10.71794152
68CDK30.71220725
69FES0.71003869
70CAMK2D0.70186344
71MAP2K70.69928982
72GRK50.69884704
73PRKCI0.69576318
74UHMK10.69007081
75EPHB20.68031133
76PRKAA10.67739328
77CASK0.67294988
78MAP3K130.66919430
79ADRBK20.65836395
80PRKAA20.62359560
81BCR0.60885237
82PRKACG0.60828536
83NEK60.59892179
84RPS6KA30.57828490
85TTK0.55624819
86SGK10.55356447
87MYLK0.54961585
88MAPKAPK50.52517703
89CSNK1A10.51979978
90MOS0.51809264
91CAMK2B0.51610448
92CDK50.50294595
93PKN10.49897836
94ZAK0.49732775
95MAPKAPK30.49066622
96PRKD20.48788868
97PRKCQ0.47832866
98CAMK10.47251755
99CDK90.47092897
100MAP3K120.46606475
101TAOK10.46506366
102GSK3B0.46187399
103AURKA0.45581976
104PRKDC0.45408151
105NUAK10.43703548
106MAPK140.42919110
107MAPK100.42774339
108NTRK30.41424357
109PRPF4B0.40908379
110CAMK40.40090764
111CAMK2A0.40088687
112NEK10.39252699
113DYRK1B0.39019883
114MAPK90.38382276
115STK110.38093163
116MAP4K20.37296819
117PHKG10.37075316
118PHKG20.37075316
119PRKCG0.37042811
120ACVR1B0.36956582
121PIK3CA0.36373243
122PLK30.36370514
123MAP2K40.36296057
124EPHA30.35435598
125PRKACA0.35083610
126MKNK20.34665715
127MARK30.34287732
128FRK0.33832632
129CAMK2G0.33783613
130CDK10.33595667
131MAP3K70.33178778
132AKT20.32961925
133PLK10.32711152
134PRKACB0.31543923
135NTRK20.31145034
136MAPK130.31087129
137RPS6KB10.30145873
138MINK10.29636369
139PRKCA0.28853097
140YES10.26544894
141SIK10.25643560
142PDK20.23925382
143WNK40.23034178
144MAPK80.22317134
145NEK20.21890974
146STK390.21484414
147CSNK1E0.21031383
148ATM0.20780924
149PRKG10.20311552
150MAPK30.19787011
151CHEK20.19176995

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15864558
2Phototransduction_Homo sapiens_hsa0474415.9316749
3Dorso-ventral axis formation_Homo sapiens_hsa043201.89103390
4Folate biosynthesis_Homo sapiens_hsa007901.80430981
5Oxidative phosphorylation_Homo sapiens_hsa001901.58918743
6Synaptic vesicle cycle_Homo sapiens_hsa047211.57243286
7Basal transcription factors_Homo sapiens_hsa030221.51611840
8Olfactory transduction_Homo sapiens_hsa047401.48148385
9Parkinsons disease_Homo sapiens_hsa050121.45776375
10Long-term depression_Homo sapiens_hsa047301.45355602
11Steroid biosynthesis_Homo sapiens_hsa001001.36289552
12Regulation of autophagy_Homo sapiens_hsa041401.32262742
13GABAergic synapse_Homo sapiens_hsa047271.22818175
14Huntingtons disease_Homo sapiens_hsa050161.18914674
15Oocyte meiosis_Homo sapiens_hsa041141.18750240
16Gap junction_Homo sapiens_hsa045401.05596189
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05345974
18Sulfur relay system_Homo sapiens_hsa041221.04176119
19Axon guidance_Homo sapiens_hsa043601.02364437
20Alzheimers disease_Homo sapiens_hsa050100.99223483
21Cholinergic synapse_Homo sapiens_hsa047250.93522159
22Hedgehog signaling pathway_Homo sapiens_hsa043400.93042595
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90854633
24Hippo signaling pathway_Homo sapiens_hsa043900.88751060
25Retinol metabolism_Homo sapiens_hsa008300.87977196
26Morphine addiction_Homo sapiens_hsa050320.87721429
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87142012
28Glutamatergic synapse_Homo sapiens_hsa047240.86586474
29Ovarian steroidogenesis_Homo sapiens_hsa049130.85357033
30Circadian rhythm_Homo sapiens_hsa047100.85168890
31Circadian entrainment_Homo sapiens_hsa047130.84698227
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81495867
33Protein export_Homo sapiens_hsa030600.79112268
34Dopaminergic synapse_Homo sapiens_hsa047280.78138694
35Nitrogen metabolism_Homo sapiens_hsa009100.76540823
36Ribosome_Homo sapiens_hsa030100.71254593
37Basal cell carcinoma_Homo sapiens_hsa052170.70542856
38Serotonergic synapse_Homo sapiens_hsa047260.69776892
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68919078
40ABC transporters_Homo sapiens_hsa020100.67089468
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65101603
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63790303
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.61228815
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60346266
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59959256
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59829914
47Nicotine addiction_Homo sapiens_hsa050330.57632193
48Insulin secretion_Homo sapiens_hsa049110.57557291
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53295032
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52997005
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51304012
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48442302
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47914736
54Oxytocin signaling pathway_Homo sapiens_hsa049210.46539347
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46503791
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46220755
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45955613
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45668762
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42942679
60Butanoate metabolism_Homo sapiens_hsa006500.41821916
61Prion diseases_Homo sapiens_hsa050200.40835955
62Purine metabolism_Homo sapiens_hsa002300.40304106
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38991757
64Fat digestion and absorption_Homo sapiens_hsa049750.38809447
65Rap1 signaling pathway_Homo sapiens_hsa040150.38213426
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38016293
67cAMP signaling pathway_Homo sapiens_hsa040240.37261195
68Renin secretion_Homo sapiens_hsa049240.35708665
69Caffeine metabolism_Homo sapiens_hsa002320.35280017
70Salivary secretion_Homo sapiens_hsa049700.35271729
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.35160688
72Inositol phosphate metabolism_Homo sapiens_hsa005620.33509256
73Dilated cardiomyopathy_Homo sapiens_hsa054140.32893422
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32633142
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32508853
76Gastric acid secretion_Homo sapiens_hsa049710.30214432
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29715656
78Glycerolipid metabolism_Homo sapiens_hsa005610.28604701
79Cocaine addiction_Homo sapiens_hsa050300.28527908
80Fructose and mannose metabolism_Homo sapiens_hsa000510.28486296
81Cardiac muscle contraction_Homo sapiens_hsa042600.28239281
82Long-term potentiation_Homo sapiens_hsa047200.27942400
83Fatty acid elongation_Homo sapiens_hsa000620.27504607
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.27448262
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27033556
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26978632
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26946875
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25631308
89mTOR signaling pathway_Homo sapiens_hsa041500.24594066
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24466732
91Chemokine signaling pathway_Homo sapiens_hsa040620.23113963
92Amphetamine addiction_Homo sapiens_hsa050310.21540639
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21264760
94Type II diabetes mellitus_Homo sapiens_hsa049300.20833648
95Lysine degradation_Homo sapiens_hsa003100.20279661
96Arginine biosynthesis_Homo sapiens_hsa002200.18920858
97Calcium signaling pathway_Homo sapiens_hsa040200.18586946
98Ras signaling pathway_Homo sapiens_hsa040140.16646716
99Glucagon signaling pathway_Homo sapiens_hsa049220.16613368
100Alcoholism_Homo sapiens_hsa050340.16515646
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.15495994
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.15258959
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14870107
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.14754643
105GnRH signaling pathway_Homo sapiens_hsa049120.13848431
106HIF-1 signaling pathway_Homo sapiens_hsa040660.13803195
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13219954
108Pancreatic secretion_Homo sapiens_hsa049720.13217800
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12515837
110MAPK signaling pathway_Homo sapiens_hsa040100.12305605
111Collecting duct acid secretion_Homo sapiens_hsa049660.11738078
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11618589
113AMPK signaling pathway_Homo sapiens_hsa041520.11546677
114Tight junction_Homo sapiens_hsa045300.11212269
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10632160
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09787777
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09784886
118Ether lipid metabolism_Homo sapiens_hsa005650.09672169
119Bile secretion_Homo sapiens_hsa049760.09593863
120Mineral absorption_Homo sapiens_hsa049780.09459565
121Linoleic acid metabolism_Homo sapiens_hsa005910.08942778
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.08656737
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.08160995
124Thyroid hormone synthesis_Homo sapiens_hsa049180.07963792
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06877686
126Taste transduction_Homo sapiens_hsa047420.06690328
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06664389
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06655560
129Choline metabolism in cancer_Homo sapiens_hsa052310.06591669
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.06269254
131Wnt signaling pathway_Homo sapiens_hsa043100.05789888
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.05585634
133Glioma_Homo sapiens_hsa052140.05559141
134Fatty acid biosynthesis_Homo sapiens_hsa000610.04385321
135Galactose metabolism_Homo sapiens_hsa000520.04124601
136mRNA surveillance pathway_Homo sapiens_hsa030150.03941498
137Insulin resistance_Homo sapiens_hsa049310.03868883
138ErbB signaling pathway_Homo sapiens_hsa040120.03497756
139Melanogenesis_Homo sapiens_hsa049160.03460420

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