RSAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.92727554
2modulation by symbiont of host defense response (GO:0052031)6.92727554
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.92727554
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.92727554
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.92727554
6modulation by symbiont of host immune response (GO:0052553)6.92727554
7cellular response to interferon-alpha (GO:0035457)6.50346544
8positive regulation of interferon-alpha production (GO:0032727)6.49638573
9type I interferon signaling pathway (GO:0060337)6.37076408
10cellular response to type I interferon (GO:0071357)6.37076408
11response to type I interferon (GO:0034340)6.31745238
12regulation of interferon-alpha production (GO:0032647)6.16107636
13response to interferon-alpha (GO:0035455)6.06788208
14response to peptidoglycan (GO:0032494)5.46440038
15cellular response to exogenous dsRNA (GO:0071360)5.42126986
16response to host immune response (GO:0052572)5.05774375
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.05774375
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01589730
19negative regulation of interleukin-12 production (GO:0032695)4.76977122
20positive regulation of cAMP-mediated signaling (GO:0043950)4.75100636
21positive regulation of interferon-beta production (GO:0032728)4.66752769
22cellular response to interferon-beta (GO:0035458)4.63798399
23macrophage activation involved in immune response (GO:0002281)4.63761185
24* negative regulation of viral genome replication (GO:0045071)4.62124799
25neutrophil activation involved in immune response (GO:0002283)4.61582237
26lipopolysaccharide-mediated signaling pathway (GO:0031663)4.57958103
27regulation of interferon-beta biosynthetic process (GO:0045357)4.56409651
28cellular response to virus (GO:0098586)4.49409534
29response to host defenses (GO:0052200)4.48031340
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.48031340
31response to host (GO:0075136)4.48031340
32regulation of T-helper 1 cell differentiation (GO:0045625)4.41512117
33natural killer cell mediated immunity (GO:0002228)4.40804692
34natural killer cell mediated cytotoxicity (GO:0042267)4.40804692
35positive regulation of chemokine biosynthetic process (GO:0045080)4.38703454
36T cell migration (GO:0072678)4.37807381
37immunoglobulin mediated immune response (GO:0016064)4.32976122
38lymphocyte chemotaxis (GO:0048247)4.28987070
39positive regulation of gamma-delta T cell activation (GO:0046645)4.17631528
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.13768808
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.13768808
42positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.13386481
43microglial cell activation (GO:0001774)4.10962250
44response to interferon-beta (GO:0035456)4.09054795
45positive regulation of natural killer cell differentiation (GO:0032825)4.06475935
46regulation of chronic inflammatory response (GO:0002676)4.05496228
47interferon-gamma-mediated signaling pathway (GO:0060333)4.04626744
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.01991297
49positive regulation of heat generation (GO:0031652)4.01756776
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.99219451
51regulation of RIG-I signaling pathway (GO:0039535)3.98212534
52regulation of vitamin D biosynthetic process (GO:0060556)3.96611909
53hydrogen peroxide biosynthetic process (GO:0050665)3.95201036
54regulation of fever generation (GO:0031620)3.89377616
55antigen processing and presentation of endogenous antigen (GO:0019883)3.82400157
56regulation of chemokine biosynthetic process (GO:0045073)3.82032811
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.79127620
58negative regulation of cell killing (GO:0031342)3.74699959
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74699959
60respiratory burst (GO:0045730)3.69844479
61granulocyte activation (GO:0036230)3.68833495
62* regulation of viral genome replication (GO:0045069)3.66222813
63* defense response to virus (GO:0051607)3.64907592
64regulation of interferon-gamma biosynthetic process (GO:0045072)3.60777609
65regulation of T cell tolerance induction (GO:0002664)3.57740995
66regulation of type I interferon-mediated signaling pathway (GO:0060338)3.57642299
67negative regulation of cytokine production involved in immune response (GO:0002719)3.56296597
68negative regulation of T cell mediated immunity (GO:0002710)3.51484998
69cellular response to interferon-gamma (GO:0071346)3.47321995
70reactive oxygen species biosynthetic process (GO:1903409)3.47243637
71response to muramyl dipeptide (GO:0032495)3.43919321
72defense response to protozoan (GO:0042832)3.42734894
73* positive regulation of type 2 immune response (GO:0002830)3.41142612
74regulation of mononuclear cell migration (GO:0071675)3.40710816
75positive regulation of interleukin-12 production (GO:0032735)3.39117131
76myeloid cell activation involved in immune response (GO:0002275)3.38144255
77positive regulation of defense response to virus by host (GO:0002230)3.36845623
78T-helper 1 type immune response (GO:0042088)3.36284727
79regulation of interferon-beta production (GO:0032648)3.34853865
80regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.33293327
81positive regulation of interleukin-17 production (GO:0032740)3.31957794
82positive regulation of lymphocyte migration (GO:2000403)3.30556546
83I-kappaB phosphorylation (GO:0007252)3.30100425
84regulation of MHC class I biosynthetic process (GO:0045343)3.29900826
85superoxide anion generation (GO:0042554)3.27899722
86detection of other organism (GO:0098543)3.25740286
87neutrophil activation (GO:0042119)3.24907125
88macrophage activation (GO:0042116)3.23587143
89response to protozoan (GO:0001562)3.23128640
90regulation of interleukin-12 production (GO:0032655)3.22819103
91monocyte chemotaxis (GO:0002548)3.22697190
92myeloid dendritic cell differentiation (GO:0043011)3.22248467
93B cell mediated immunity (GO:0019724)3.21658476
94negative regulation of myeloid cell apoptotic process (GO:0033033)3.19766204
95eosinophil chemotaxis (GO:0048245)3.19551590
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18849645
97regulation of cytokine secretion involved in immune response (GO:0002739)3.17999609
98* regulation of type 2 immune response (GO:0002828)3.16873360
99regulation of tolerance induction (GO:0002643)3.15556779
100response to exogenous dsRNA (GO:0043330)3.14405141
101natural killer cell activation involved in immune response (GO:0002323)3.13867894
102regulation of defense response to virus by host (GO:0050691)3.12408185
103NIK/NF-kappaB signaling (GO:0038061)3.11850583
104response to interferon-gamma (GO:0034341)3.10972846
105regulation of interleukin-17 production (GO:0032660)3.09606760
106regulation of vitamin metabolic process (GO:0030656)3.07804136
107positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.07535017
108cellular response to lipopolysaccharide (GO:0071222)3.06249181
109positive regulation of response to biotic stimulus (GO:0002833)3.05438000
110regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04708339
111regulation of antigen processing and presentation (GO:0002577)3.04511159
112negative regulation of type I interferon production (GO:0032480)3.04393505
113detection of external biotic stimulus (GO:0098581)3.03903369
114regulation of podosome assembly (GO:0071801)3.03674607
115positive regulation of cellular amide metabolic process (GO:0034250)3.02384996
116leukocyte mediated cytotoxicity (GO:0001909)3.02155064
117detection of molecule of bacterial origin (GO:0032490)3.01632321
118regulation of T-helper cell differentiation (GO:0045622)3.01551747
119germinal center formation (GO:0002467)3.01293395
120cellular response to molecule of bacterial origin (GO:0071219)3.01247542
121positive regulation of NF-kappaB import into nucleus (GO:0042346)3.00782697
122regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.00731582
123positive regulation of chemokine production (GO:0032722)2.99809487
124regulation of heat generation (GO:0031650)2.99529695
125production of molecular mediator involved in inflammatory response (GO:0002532)2.99383038
126positive regulation of antigen processing and presentation (GO:0002579)2.99233706
127detection of bacterium (GO:0016045)2.98833947
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96420594
129negative regulation of type 2 immune response (GO:0002829)2.96132354
130regulation of T-helper 2 cell differentiation (GO:0045628)2.95979886
131negative regulation of interleukin-17 production (GO:0032700)2.95361879
132regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.91722044
133* negative regulation of viral process (GO:0048525)2.91416871
134interferon-gamma secretion (GO:0072643)2.90922733
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.90903474
136regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90864044
137regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.90214723
138regulation of immunoglobulin secretion (GO:0051023)2.89737724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.28486826
2IRF8_21731497_ChIP-ChIP_J774_Mouse8.02937332
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.57911549
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.58990148
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.34141776
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.53265346
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84451873
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.73830636
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.68731343
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.32847764
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.11516199
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91466385
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80136250
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54485394
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39194916
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32959934
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.31788589
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.27423096
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19170917
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90159652
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65989479
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62004192
23PU_27001747_Chip-Seq_BMDM_Mouse1.56364973
24SPI1_23547873_ChIP-Seq_NB4_Human1.55197107
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53388879
26CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50311953
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46920517
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45766035
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40442799
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.39600507
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.37621200
32* MYB_26560356_Chip-Seq_TH2_Human1.35054466
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28047273
34VDR_21846776_ChIP-Seq_THP-1_Human1.27640858
35EGR1_19032775_ChIP-ChIP_M12_Human1.27479105
36VDR_24787735_ChIP-Seq_THP-1_Human1.26958748
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24490827
38MAF_26560356_Chip-Seq_TH1_Human1.19512531
39CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18666945
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.18167086
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17451280
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16003583
43PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14659122
44MYB_26560356_Chip-Seq_TH1_Human1.13328231
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.11046463
46* GATA3_26560356_Chip-Seq_TH2_Human1.10416135
47CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09967695
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.09626685
49RUNX_20019798_ChIP-Seq_JUKART_Human1.08219187
50VDR_24763502_ChIP-Seq_THP-1_Human1.07353793
51SPI1_23127762_ChIP-Seq_K562_Human1.06654989
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06297686
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06150608
54SOX2_20726797_ChIP-Seq_SW620_Human1.03646318
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03214322
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02066828
57SCL_19346495_ChIP-Seq_HPC-7_Human1.02061752
58* GATA1_19941826_ChIP-Seq_K562_Human0.97319209
59GATA3_27048872_Chip-Seq_THYMUS_Human0.96777376
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95815269
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95599754
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93652100
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93360415
64KDM2B_26808549_Chip-Seq_DND41_Human0.93282547
65NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89203850
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89203850
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88877780
68TCF7_22412390_ChIP-Seq_EML_Mouse0.88835779
69* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88284142
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85552462
71CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84984421
72STAT1_20625510_ChIP-Seq_HELA_Human0.84902244
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84222100
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81633273
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78920031
76ESR2_21235772_ChIP-Seq_MCF-7_Human0.77181492
77* GATA1_22025678_ChIP-Seq_K562_Human0.74576106
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74044437
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70689787
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70604129
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70580712
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69911847
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69496790
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.69324682
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67267883
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65478346
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65418244
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.65165526
89TFEB_21752829_ChIP-Seq_HELA_Human0.65163700
90UTX_26944678_Chip-Seq_JUKART_Human0.62878871
91CJUN_26792858_Chip-Seq_BT549_Human0.62603534
92SMRT_27268052_Chip-Seq_Bcells_Human0.62280701
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62194101
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61198863
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60584843
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60212875
97* LXR_22158963_ChIP-Seq_LIVER_Mouse0.59977033
98* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59009662
99* RXR_22158963_ChIP-Seq_LIVER_Mouse0.58981033
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.57922289
101LXR_22292898_ChIP-Seq_THP-1_Human0.57855046
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.56896078
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.56893485
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.56514444
105IKZF1_21737484_ChIP-ChIP_HCT116_Human0.56471749
106MAF_26560356_Chip-Seq_TH2_Human0.55406799
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55340397
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.53899995
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53177429
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.52548774
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.52548774
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.52097814
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.51481911
114* GATA2_19941826_ChIP-Seq_K562_Human0.51014516
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.50802147
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.50766568
117SPI1_20517297_ChIP-Seq_HL60_Human0.50526946
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.50437784
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49976959
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.49675229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.60276556
2MP0006082_CNS_inflammation4.25670564
3MP0001835_abnormal_antigen_presentation4.21998348
4MP0003724_increased_susceptibility_to4.06168791
5MP0003303_peritoneal_inflammation3.89269665
6MP0002148_abnormal_hypersensitivity_rea3.74527989
7MP0003436_decreased_susceptibility_to3.68213109
8MP0005000_abnormal_immune_tolerance3.29643290
9MP0005025_abnormal_response_to3.23113352
10MP0004510_myositis3.19870752
11MP0005387_immune_system_phenotype3.06321826
12MP0001790_abnormal_immune_system3.06321826
13MP0002419_abnormal_innate_immunity2.99654075
14MP0000685_abnormal_immune_system2.69379428
15MP0005671_abnormal_response_to2.57235151
16* MP0002452_abnormal_antigen_presenting2.48890156
17* MP0002723_abnormal_immune_serum2.48741528
18MP0005058_abnormal_lysosome_morphology2.41210371
19* MP0001800_abnormal_humoral_immune2.39970815
20MP0001533_abnormal_skeleton_physiology2.35810871
21MP0009764_decreased_sensitivity_to2.34228704
22MP0004947_skin_inflammation2.22594802
23* MP0001819_abnormal_immune_cell2.05448285
24MP0003075_altered_response_to1.99801651
25MP0003448_altered_tumor_morphology1.97689528
26* MP0002420_abnormal_adaptive_immunity1.96758764
27MP0005451_abnormal_body_composition1.92623295
28MP0008469_abnormal_protein_level1.90925085
29MP0004858_abnormal_nervous_system1.89710925
30MP0005464_abnormal_platelet_physiology1.87081192
31MP0001853_heart_inflammation1.86937658
32MP0009278_abnormal_bone_marrow1.85852754
33MP0001845_abnormal_inflammatory_respons1.83760282
34MP0000604_amyloidosis1.76082069
35MP0002006_tumorigenesis1.71873758
36MP0000343_altered_response_to1.69543631
37MP0010155_abnormal_intestine_physiology1.68777647
38MP0003172_abnormal_lysosome_physiology1.64797090
39MP0005167_abnormal_blood-brain_barrier1.61069123
40MP0005164_abnormal_response_to1.52852424
41MP0002139_abnormal_hepatobiliary_system1.44189754
42MP0005397_hematopoietic_system_phenotyp1.44030694
43MP0001545_abnormal_hematopoietic_system1.44030694
44MP0002998_abnormal_bone_remodeling1.43742795
45MP0009840_abnormal_foam_cell1.41611283
46* MP0000716_abnormal_immune_system1.40909390
47MP0002405_respiratory_system_inflammati1.40302240
48MP0002277_abnormal_respiratory_mucosa1.40154367
49MP0010307_abnormal_tumor_latency1.37701322
50MP0005166_decreased_susceptibility_to1.35911354
51MP0004782_abnormal_surfactant_physiolog1.34986403
52MP0009333_abnormal_splenocyte_physiolog1.34801189
53MP0006054_spinal_hemorrhage1.32705003
54MP0003690_abnormal_glial_cell1.29438932
55* MP0002398_abnormal_bone_marrow1.26712596
56MP0000858_altered_metastatic_potential1.24623925
57MP0003191_abnormal_cellular_cholesterol1.22987963
58MP0003186_abnormal_redox_activity1.22055052
59MP0005310_abnormal_salivary_gland1.18909499
60MP0003806_abnormal_nucleotide_metabolis1.16337491
61MP0009763_increased_sensitivity_to1.14138427
62MP0002166_altered_tumor_susceptibility1.08722574
63* MP0002429_abnormal_blood_cell1.08545921
64MP0005390_skeleton_phenotype1.06636903
65MP0003300_gastrointestinal_ulcer1.06401834
66MP0002332_abnormal_exercise_endurance1.01557797
67MP0000689_abnormal_spleen_morphology0.98796148
68MP0003195_calcinosis0.95710425
69MP0001501_abnormal_sleep_pattern0.90969764
70MP0002722_abnormal_immune_system0.90092850
71MP0010352_gastrointestinal_tract_polyps0.87809228
72MP0003045_fibrosis0.86626145
73MP0003453_abnormal_keratinocyte_physiol0.86051175
74MP0002138_abnormal_hepatobiliary_system0.81701824
75MP0003091_abnormal_cell_migration0.80917794
76MP0003221_abnormal_cardiomyocyte_apopto0.78489171
77MP0000465_gastrointestinal_hemorrhage0.78236307
78MP0000569_abnormal_digit_pigmentation0.77195557
79MP0008260_abnormal_autophagy0.77172123
80MP0001851_eye_inflammation0.74941785
81MP0003656_abnormal_erythrocyte_physiolo0.73947339
82MP0001542_abnormal_bone_strength0.73457260
83MP0008874_decreased_physiological_sensi0.73037511
84MP0001663_abnormal_digestive_system0.72199136
85MP0003646_muscle_fatigue0.71595345
86MP0005076_abnormal_cell_differentiation0.71506524
87MP0008004_abnormal_stomach_pH0.70681824
88MP0000249_abnormal_blood_vessel0.69997339
89MP0005083_abnormal_biliary_tract0.68281688
90MP0002254_reproductive_system_inflammat0.67120730
91MP0003866_abnormal_defecation0.65849839
92MP0003329_amyloid_beta_deposits0.65349027
93MP0003828_pulmonary_edema0.64346702
94MP0008775_abnormal_heart_ventricle0.63902355
95MP0002136_abnormal_kidney_physiology0.62258394
96MP0005023_abnormal_wound_healing0.61667517
97MP0002933_joint_inflammation0.60050700
98MP0005165_increased_susceptibility_to0.58821215
99MP0005319_abnormal_enzyme/_coenzyme0.57988317
100MP0001881_abnormal_mammary_gland0.57873851
101MP0000703_abnormal_thymus_morphology0.57866915
102MP0004808_abnormal_hematopoietic_stem0.57265124
103MP0009765_abnormal_xenobiotic_induced0.56441283
104MP0003763_abnormal_thymus_physiology0.56178038
105MP0002877_abnormal_melanocyte_morpholog0.53864861
106MP0003183_abnormal_peptide_metabolism0.53194057
107MP0003795_abnormal_bone_structure0.51676815
108MP0000920_abnormal_myelination0.50893875
109MP0001958_emphysema0.48902898
110MP0003566_abnormal_cell_adhesion0.48773451
111MP0002693_abnormal_pancreas_physiology0.47374526
112MP0004883_abnormal_blood_vessel0.46773313
113MP0005535_abnormal_body_temperature0.45931248
114MP0000371_diluted_coat_color0.45824088

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.02266738
2Recurrent abscess formation (HP:0002722)6.80892227
3Recurrent bacterial skin infections (HP:0005406)6.61116955
4Autoimmune thrombocytopenia (HP:0001973)6.00193815
5Recurrent gram-negative bacterial infections (HP:0005420)5.95852085
6Abnormality of macrophages (HP:0004311)5.35833989
7Mediastinal lymphadenopathy (HP:0100721)5.29855794
8Increased IgM level (HP:0003496)5.09678745
9Elevated erythrocyte sedimentation rate (HP:0003565)4.98062633
10Basal ganglia calcification (HP:0002135)4.55407130
11Stomatitis (HP:0010280)4.44018996
12Systemic lupus erythematosus (HP:0002725)4.22924648
13Prostate neoplasm (HP:0100787)4.15179754
14Keratoconjunctivitis (HP:0001096)4.13101528
15Vasculitis (HP:0002633)4.07122781
16Recurrent skin infections (HP:0001581)4.06074327
17Tetraparesis (HP:0002273)4.00762649
18Gingivitis (HP:0000230)3.98189874
19Chronic otitis media (HP:0000389)3.91366080
20Orchitis (HP:0100796)3.83269380
21Recurrent viral infections (HP:0004429)3.74893839
22Porencephaly (HP:0002132)3.72172428
23Increased cerebral lipofuscin (HP:0011813)3.70287002
24Myositis (HP:0100614)3.64829309
25Recurrent fungal infections (HP:0002841)3.62675794
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.59010798
27Hypergammaglobulinemia (HP:0010702)3.56446867
28Retrobulbar optic neuritis (HP:0100654)3.55342898
29Optic neuritis (HP:0100653)3.55342898
30Vacuolated lymphocytes (HP:0001922)3.46922139
31Interstitial pulmonary disease (HP:0006530)3.45058231
32T lymphocytopenia (HP:0005403)3.37092774
33Abnormality of T cell number (HP:0011839)3.31745870
34Obstructive lung disease (HP:0006536)3.27965668
35Chronic obstructive pulmonary disease (HP:0006510)3.27965668
36Thick nail (HP:0001805)3.23024719
37Periodontitis (HP:0000704)3.13082819
38Autoimmune hemolytic anemia (HP:0001890)3.02603562
39Gangrene (HP:0100758)3.00997058
40Encephalitis (HP:0002383)2.99516325
41Pustule (HP:0200039)2.99184467
42Axonal loss (HP:0003447)2.83787423
43Nasal polyposis (HP:0100582)2.82083282
44Dysostosis multiplex (HP:0000943)2.81827584
45Urticaria (HP:0001025)2.81378846
46Pulmonary infiltrates (HP:0002113)2.80583183
47Premature loss of primary teeth (HP:0006323)2.79679598
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.77163998
49Cellulitis (HP:0100658)2.74585072
50Recurrent cutaneous fungal infections (HP:0011370)2.71788174
51Chronic mucocutaneous candidiasis (HP:0002728)2.71788174
52Cleft eyelid (HP:0000625)2.66678387
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62473244
54Disinhibition (HP:0000734)2.58019252
55Abnormality of the nasal mucosa (HP:0000433)2.57621675
56Recurrent pneumonia (HP:0006532)2.57272285
57Poor head control (HP:0002421)2.54850331
58Neoplasm of head and neck (HP:0012288)2.53865663
59Esophageal neoplasm (HP:0100751)2.53865663
60Polyneuropathy (HP:0001271)2.46264596
61Recurrent lower respiratory tract infections (HP:0002783)2.44869010
62Abnormality of the endocardium (HP:0004306)2.44718047
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.40595846
64Hepatosplenomegaly (HP:0001433)2.39812269
65Osteomyelitis (HP:0002754)2.39259186
66Increased IgE level (HP:0003212)2.39092592
67Abnormality of B cell number (HP:0010975)2.38273441
68Episodic fever (HP:0001954)2.38220392
69Pulmonary embolism (HP:0002204)2.38022292
70Osteolytic defects of the hand bones (HP:0009699)2.37906227
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.37906227
72Gastrointestinal infarctions (HP:0005244)2.37705680
73Gingival bleeding (HP:0000225)2.37575359
74Hematochezia (HP:0002573)2.35219188
75Amyloidosis (HP:0011034)2.34803576
76Myocardial infarction (HP:0001658)2.34766484
77Leukocytosis (HP:0001974)2.34410504
78Progressive neurologic deterioration (HP:0002344)2.33263449
79Lower limb hyperreflexia (HP:0002395)2.32850289
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32397166
81Chronic sinusitis (HP:0011109)2.32203238
82Vertigo (HP:0002321)2.32090841
83Recurrent bronchitis (HP:0002837)2.32054240
84Plagiocephaly (HP:0001357)2.30696403
85Glomerulonephritis (HP:0000099)2.29972371
86Vertebral compression fractures (HP:0002953)2.29782790
87Bone pain (HP:0002653)2.29603305
88Joint swelling (HP:0001386)2.27589541
89Abnormality of the pericardium (HP:0001697)2.26905255
90Purpura (HP:0000979)2.24816014
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24564617
92Abnormality of polysaccharide metabolism (HP:0011012)2.24564617
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24564617
94Nephritis (HP:0000123)2.24502036
95Petechiae (HP:0000967)2.24421264
96Hemoptysis (HP:0002105)2.23940429
97Prolonged neonatal jaundice (HP:0006579)2.21574116
98Keratitis (HP:0000491)2.20098944
99Abnormality of liposaccharide metabolism (HP:0010968)2.19749088
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.19749088
101Abnormality of glycolipid metabolism (HP:0010969)2.19749088
102Loss of speech (HP:0002371)2.17849589
103Glomerulopathy (HP:0100820)2.17319614
104Spastic tetraparesis (HP:0001285)2.17256210
105Abnormality of the prostate (HP:0008775)2.16092775
106Acne (HP:0001061)2.16044891
107Progressive visual loss (HP:0000529)2.15766858
108Arterial thrombosis (HP:0004420)2.13602776
109Meningitis (HP:0001287)2.12937567
110Urinary glycosaminoglycan excretion (HP:0003541)2.11415114
111Mucopolysacchariduria (HP:0008155)2.11415114
112Anorexia (HP:0002039)2.11127754
113Pathologic fracture (HP:0002756)2.08933826
114Increased serum ferritin (HP:0003281)2.08896712
115B lymphocytopenia (HP:0010976)2.07796010
116Chest pain (HP:0100749)2.07338055
117Abnormality of iron homeostasis (HP:0011031)2.07320571
118Abnormality of T cells (HP:0002843)2.06239237
119Mutism (HP:0002300)2.05032913
120Abnormality of the basal ganglia (HP:0002134)2.04120396
121Hemorrhage of the eye (HP:0011885)2.03348365
122Cheilitis (HP:0100825)2.01746548
123Spontaneous hematomas (HP:0007420)2.01690475
124Nausea (HP:0002018)2.00814523
125Eosinophilia (HP:0001880)1.99610048
126Neurofibrillary tangles (HP:0002185)1.98529402
127Skin ulcer (HP:0200042)1.98270125
128Arthralgia (HP:0002829)1.96578137
129Parakeratosis (HP:0001036)1.95964139
130Keratoconjunctivitis sicca (HP:0001097)1.95606944
131Abnormality of the pleura (HP:0002103)1.95215833
132Memory impairment (HP:0002354)1.91635808
133Peritonitis (HP:0002586)1.90820606
134IgA deficiency (HP:0002720)1.88866824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.15163072
2MAP3K144.25844949
3TYK24.20459903
4TBK14.12258351
5IKBKE3.77887222
6RIPK43.49862710
7IRAK43.25272051
8JAK12.76309728
9JAK32.73572379
10BLK2.68766344
11PIM22.68627923
12IRAK32.62793278
13MAP3K132.29423081
14KIT2.25401228
15IKBKB2.16910100
16PRPF4B2.10328760
17TAOK22.05328173
18ERN11.95264938
19FGFR41.94031485
20TXK1.72430539
21DDR21.66960880
22MAP2K31.66419116
23TAOK11.64232134
24ARAF1.57169539
25MAP3K31.54626222
26MAP3K51.54224317
27CSK1.54135116
28MAP4K11.42232415
29IRAK11.39520976
30MATK1.35972945
31CHUK1.35529452
32BMX1.27387271
33FGFR31.24003442
34EPHA31.20121615
35CDC42BPA1.18641282
36SYK1.16863050
37FGR1.16816884
38EPHB11.16637385
39STK41.16479645
40IRAK21.15990753
41BMPR21.15642217
42TAOK31.12016443
43EIF2AK21.11733005
44HCK1.09196555
45ABL21.05841348
46MST41.04211221
47ZAP701.02908861
48RPS6KA41.02340600
49JAK20.98120701
50MARK30.95764145
51LYN0.95182792
52NEK90.94278416
53PIM10.93754276
54MST1R0.90693884
55LCK0.90292576
56TNK20.86526862
57HIPK20.79298376
58NME20.71631634
59ACVR1B0.69094931
60EGFR0.60804617
61TYRO30.60402680
62MAP2K60.58758659
63DAPK30.58533009
64DYRK30.57982444
65FES0.57258939
66SIK30.57102081
67PRKCD0.56980510
68ABL10.56878714
69CLK10.55180271
70PLK20.54351236
71STK30.52738586
72MAP3K90.51213176
73GRK70.50538378
74ITK0.48891891
75PRKCQ0.47291907
76MOS0.46787961
77CSF1R0.46352074
78YES10.46023885
79RPS6KA50.43107847
80MAPK70.42808728
81KSR20.41590143
82STK100.40795978
83BTK0.40533599
84MAP3K10.38688393
85DAPK20.36189151
86TRPM70.34178601
87NLK0.34039330
88ERBB30.31801581
89ERBB40.31241746
90SIK20.30915468
91MAP3K100.30903617
92MAP3K60.30385769
93ADRBK20.30317307
94FYN0.28236797
95GRK60.27698546
96PRKD20.27686996
97RIPK10.27578504
98MARK20.27008864
99CDK60.25633364
100DYRK1B0.24756099
101PDPK10.23760920
102MAPK110.23323361
103TEC0.22961481
104ALK0.22685131
105CDK40.22488781
106PKN10.21882336
107PDGFRB0.21331654
108PLK40.21331058
109CAMKK20.21113880
110MAP3K110.18514031
111BMPR1B0.17405409
112SGK10.16942078
113MAPK40.16830858
114TESK20.16231247
115MAPKAPK20.15380211
116PDK10.15318333
117CAMK1D0.14210632
118MAPK30.14171283
119IGF1R0.13804469
120SRC0.13095752
121INSR0.12976703
122TGFBR20.12777010
123RPS6KA60.12441529
124PRKCE0.12220450
125PRKG20.11726504
126TESK10.10491871

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.60285028
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.59598223
3Leishmaniasis_Homo sapiens_hsa051403.31889893
4Graft-versus-host disease_Homo sapiens_hsa053323.31469720
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.20438594
6Staphylococcus aureus infection_Homo sapiens_hsa051502.98630514
7Allograft rejection_Homo sapiens_hsa053302.87406596
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.67427386
9Measles_Homo sapiens_hsa051622.56494230
10Legionellosis_Homo sapiens_hsa051342.43301369
11Malaria_Homo sapiens_hsa051442.42478120
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41908381
13* Influenza A_Homo sapiens_hsa051642.41876713
14Pertussis_Homo sapiens_hsa051332.35288236
15Asthma_Homo sapiens_hsa053102.25804171
16TNF signaling pathway_Homo sapiens_hsa046682.22648768
17Rheumatoid arthritis_Homo sapiens_hsa053232.20285193
18Type I diabetes mellitus_Homo sapiens_hsa049402.10193164
19Intestinal immune network for IgA production_Homo sapiens_hsa046722.09768734
20Herpes simplex infection_Homo sapiens_hsa051682.08712251
21Osteoclast differentiation_Homo sapiens_hsa043802.08181273
22Tuberculosis_Homo sapiens_hsa051522.05227386
23African trypanosomiasis_Homo sapiens_hsa051432.00865133
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97254030
25Salmonella infection_Homo sapiens_hsa051321.71974355
26Toxoplasmosis_Homo sapiens_hsa051451.61517578
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59039208
28Hepatitis C_Homo sapiens_hsa051601.56446059
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45032416
30Chemokine signaling pathway_Homo sapiens_hsa040621.38531366
31Phagosome_Homo sapiens_hsa041451.34020861
32Autoimmune thyroid disease_Homo sapiens_hsa053201.33383107
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.28444337
34Hepatitis B_Homo sapiens_hsa051611.25924545
35Lysosome_Homo sapiens_hsa041421.24834508
36Apoptosis_Homo sapiens_hsa042101.21187220
37Antigen processing and presentation_Homo sapiens_hsa046121.14488332
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13451355
39Hematopoietic cell lineage_Homo sapiens_hsa046401.12870904
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08953945
41B cell receptor signaling pathway_Homo sapiens_hsa046621.08054184
42Shigellosis_Homo sapiens_hsa051311.07697004
43Viral myocarditis_Homo sapiens_hsa054161.07597390
44Prion diseases_Homo sapiens_hsa050200.95392697
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92363979
46Amoebiasis_Homo sapiens_hsa051460.90119842
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89154641
48Primary immunodeficiency_Homo sapiens_hsa053400.86466160
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83790637
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81586036
51Prolactin signaling pathway_Homo sapiens_hsa049170.70158508
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.66701692
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63209890
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61829456
55Bladder cancer_Homo sapiens_hsa052190.57773652
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.54203866
57Type II diabetes mellitus_Homo sapiens_hsa049300.52451612
58HIF-1 signaling pathway_Homo sapiens_hsa040660.50934900
59Complement and coagulation cascades_Homo sapiens_hsa046100.50866182
60Acute myeloid leukemia_Homo sapiens_hsa052210.50374387
61Mineral absorption_Homo sapiens_hsa049780.49804492
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.48503575
63Dorso-ventral axis formation_Homo sapiens_hsa043200.47844577
64T cell receptor signaling pathway_Homo sapiens_hsa046600.47486047
65Small cell lung cancer_Homo sapiens_hsa052220.46987078
66Collecting duct acid secretion_Homo sapiens_hsa049660.46366924
67Epstein-Barr virus infection_Homo sapiens_hsa051690.43388858
68Caffeine metabolism_Homo sapiens_hsa002320.43232265
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41235175
70Chronic myeloid leukemia_Homo sapiens_hsa052200.40611081
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.39557645
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38865520
73Arginine biosynthesis_Homo sapiens_hsa002200.35841405
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.35605768
75Viral carcinogenesis_Homo sapiens_hsa052030.34923152
76Pancreatic cancer_Homo sapiens_hsa052120.34898097
77Other glycan degradation_Homo sapiens_hsa005110.34733085
78Notch signaling pathway_Homo sapiens_hsa043300.34258297
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33880165
80Platelet activation_Homo sapiens_hsa046110.32918077
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30952134
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29438595
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28516360
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24541390
85Proteasome_Homo sapiens_hsa030500.20386042
86Systemic lupus erythematosus_Homo sapiens_hsa053220.19735081
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19055320
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18672794
89Insulin resistance_Homo sapiens_hsa049310.18664477
90Tryptophan metabolism_Homo sapiens_hsa003800.18433996
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17844792
92Proteoglycans in cancer_Homo sapiens_hsa052050.17056988
93VEGF signaling pathway_Homo sapiens_hsa043700.16802950
94Sulfur metabolism_Homo sapiens_hsa009200.16772953
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.16053895
96Renal cell carcinoma_Homo sapiens_hsa052110.15509844
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.15452797
98HTLV-I infection_Homo sapiens_hsa051660.14826941
99Non-small cell lung cancer_Homo sapiens_hsa052230.14346500
100Fatty acid biosynthesis_Homo sapiens_hsa000610.13374138
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10957534
102MicroRNAs in cancer_Homo sapiens_hsa052060.10941637
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09593499
104FoxO signaling pathway_Homo sapiens_hsa040680.08920835
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08836377
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07060180
107GnRH signaling pathway_Homo sapiens_hsa049120.06520073
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06437636
109mTOR signaling pathway_Homo sapiens_hsa041500.06315890
110Prostate cancer_Homo sapiens_hsa052150.04912952
111MAPK signaling pathway_Homo sapiens_hsa040100.03513901
112Sphingolipid metabolism_Homo sapiens_hsa006000.03491409
113Endocytosis_Homo sapiens_hsa041440.00947473

Most similar genes based on co-expression Upload to Enrichr

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