RSBN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.57926591
2positive regulation of gamma-delta T cell activation (GO:0046645)4.68229194
3nucleobase catabolic process (GO:0046113)4.42973206
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24357142
5mitotic sister chromatid cohesion (GO:0007064)4.21140393
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21016731
7negative regulation of cell killing (GO:0031342)4.21016731
8definitive hemopoiesis (GO:0060216)3.80328962
9positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.73862590
10mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.73862590
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73554341
12monoubiquitinated protein deubiquitination (GO:0035520)3.67216794
13regulation of gamma-delta T cell differentiation (GO:0045586)3.61862008
14pre-miRNA processing (GO:0031054)3.57235993
15nuclear pore complex assembly (GO:0051292)3.55607278
16regulation of histone H3-K9 methylation (GO:0051570)3.52291580
17cytoplasmic mRNA processing body assembly (GO:0033962)3.51472923
18central nervous system projection neuron axonogenesis (GO:0021952)3.41773003
19behavioral response to nicotine (GO:0035095)3.40797464
20regulation of gamma-delta T cell activation (GO:0046643)3.37012932
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36600089
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36600089
23negative T cell selection (GO:0043383)3.32994858
24negative regulation of histone methylation (GO:0031061)3.32320602
25presynaptic membrane assembly (GO:0097105)3.31429616
26presynaptic membrane organization (GO:0097090)3.30743521
27behavioral response to ethanol (GO:0048149)3.25285414
28negative thymic T cell selection (GO:0045060)3.24302708
29activated T cell proliferation (GO:0050798)3.22989210
30positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.11648979
31regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.11648979
32centriole replication (GO:0007099)3.07647754
33positive regulation of histone deacetylation (GO:0031065)3.03532669
34resolution of meiotic recombination intermediates (GO:0000712)3.03154595
35regulation of RNA export from nucleus (GO:0046831)3.03127359
36regulation of DNA endoreduplication (GO:0032875)3.02455350
37somite development (GO:0061053)3.01973478
38positive thymic T cell selection (GO:0045059)3.01668862
39nuclear pore organization (GO:0006999)3.01173862
40protein K11-linked deubiquitination (GO:0035871)3.01147018
41antigen processing and presentation of endogenous antigen (GO:0019883)2.98141534
42dendritic spine morphogenesis (GO:0060997)2.97469947
43DNA unwinding involved in DNA replication (GO:0006268)2.93237462
44T cell homeostasis (GO:0043029)2.93143420
45nonmotile primary cilium assembly (GO:0035058)2.91268439
46megakaryocyte development (GO:0035855)2.89304428
47transmission of nerve impulse (GO:0019226)2.88464829
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87897580
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.87897580
50regulation of translation, ncRNA-mediated (GO:0045974)2.87897580
51mRNA splice site selection (GO:0006376)2.87818416
52RNA stabilization (GO:0043489)2.83617266
53mRNA stabilization (GO:0048255)2.83617266
54forebrain neuron differentiation (GO:0021879)2.83404672
55positive T cell selection (GO:0043368)2.83368712
56limb bud formation (GO:0060174)2.83161764
57protein-DNA complex disassembly (GO:0032986)2.82753166
58nucleosome disassembly (GO:0006337)2.82753166
593-UTR-mediated mRNA stabilization (GO:0070935)2.81383898
60positive regulation of erythrocyte differentiation (GO:0045648)2.81087294
61thymic T cell selection (GO:0045061)2.80985380
62central nervous system neuron axonogenesis (GO:0021955)2.79765539
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79155644
64histone H3-K4 trimethylation (GO:0080182)2.78427543
65intraciliary transport (GO:0042073)2.77810344
66glial cell proliferation (GO:0014009)2.77728334
67nerve growth factor signaling pathway (GO:0038180)2.76524599
68neuron cell-cell adhesion (GO:0007158)2.76271844
69T cell selection (GO:0045058)2.73756432
70positive regulation of developmental pigmentation (GO:0048087)2.73335196
71positive regulation of mitochondrial fission (GO:0090141)2.73202208
72DNA topological change (GO:0006265)2.72597505
73embryonic hemopoiesis (GO:0035162)2.69341218
74regulation of erythrocyte differentiation (GO:0045646)2.69054225
75epithelial cell differentiation involved in kidney development (GO:0035850)2.68816032
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.68636770
77positive regulation of B cell differentiation (GO:0045579)2.67253950
78histone mRNA catabolic process (GO:0071044)2.66871128
79establishment of protein localization to Golgi (GO:0072600)2.65567184
80ribosomal small subunit assembly (GO:0000028)2.64696477
81pore complex assembly (GO:0046931)2.64137889
82synapse assembly (GO:0007416)2.63271873
83positive regulation of granulocyte differentiation (GO:0030854)2.62310051
84ionotropic glutamate receptor signaling pathway (GO:0035235)2.62271975
85alternative mRNA splicing, via spliceosome (GO:0000380)2.62202535
86B cell homeostasis (GO:0001782)2.62114609
87negative regulation of RNA splicing (GO:0033119)2.61498409
88dentate gyrus development (GO:0021542)2.61317429
89protein targeting to Golgi (GO:0000042)2.61042264
90peptidyl-lysine trimethylation (GO:0018023)2.58234475
91glucocorticoid receptor signaling pathway (GO:0042921)2.57911751
92positive regulation of mRNA processing (GO:0050685)2.57184520
93phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.57054232
94regulation of telomere maintenance (GO:0032204)2.56527527
95positive regulation of mRNA catabolic process (GO:0061014)2.56503656
96regulation of B cell receptor signaling pathway (GO:0050855)2.56306355
97embryonic epithelial tube formation (GO:0001838)2.55221149
98regulation of nucleobase-containing compound transport (GO:0032239)2.53853092
99mast cell activation (GO:0045576)2.53816455
100chromatin assembly (GO:0031497)2.53574611
101positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53466150
102histone H3-K9 methylation (GO:0051567)2.53002846
103lymphocyte homeostasis (GO:0002260)2.52929054
104germ cell migration (GO:0008354)2.52887650
105negative regulation of erythrocyte differentiation (GO:0045647)2.52806209
106sequestering of actin monomers (GO:0042989)2.52561180
107histone H3-K9 demethylation (GO:0033169)2.52519553
108fucose catabolic process (GO:0019317)2.52255371
109L-fucose metabolic process (GO:0042354)2.52255371
110L-fucose catabolic process (GO:0042355)2.52255371
111positive regulation of mRNA metabolic process (GO:1903313)2.52027160
112B cell receptor signaling pathway (GO:0050853)2.51954141
113kidney morphogenesis (GO:0060993)2.51789784
114response to interleukin-15 (GO:0070672)2.51725564
115establishment of mitochondrion localization (GO:0051654)2.51702048
116interferon-gamma production (GO:0032609)2.51442524
117positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50207585
118negative regulation of DNA repair (GO:0045738)2.50016007
119positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49916940
120regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49916940
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48239199
122histone H3-K4 methylation (GO:0051568)2.47567980
123negative regulation of B cell proliferation (GO:0030889)2.46738683
124positive regulation of growth hormone secretion (GO:0060124)2.46620362
125DNA demethylation (GO:0080111)2.46295186
126regulation of regulatory T cell differentiation (GO:0045589)2.46186440
127retrograde transport, vesicle recycling within Golgi (GO:0000301)2.45853240
128regulation of B cell differentiation (GO:0045577)2.45414277
129neuron fate determination (GO:0048664)2.44844769
130regulation of mRNA stability (GO:0043488)2.44175099
131histone deubiquitination (GO:0016578)2.43768531
132cerebellar Purkinje cell differentiation (GO:0021702)2.43340570
133gamma-aminobutyric acid transport (GO:0015812)2.43302362
134antigen processing and presentation via MHC class Ib (GO:0002475)2.42979826
135startle response (GO:0001964)2.41473251
136neuronal action potential (GO:0019228)2.40738340
137protein localization to cilium (GO:0061512)2.40676974
138peptidyl-lysine methylation (GO:0018022)2.40455453
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40284701
140epithelial cilium movement (GO:0003351)2.38497620
141regulation of mRNA catabolic process (GO:0061013)2.37813708
142pyrimidine dimer repair (GO:0006290)2.37431370
143translesion synthesis (GO:0019985)2.36838314
144negative regulation of phagocytosis (GO:0050765)2.36737555
145viral transcription (GO:0019083)2.36594101
146positive regulation of mRNA 3-end processing (GO:0031442)2.36048239
147T cell migration (GO:0072678)2.35919691
148axonal fasciculation (GO:0007413)2.35661781
149lymphoid progenitor cell differentiation (GO:0002320)2.35643306
150peptidyl-lysine dimethylation (GO:0018027)2.34776240
151negative regulation of mast cell activation (GO:0033004)2.34394526
152olfactory bulb development (GO:0021772)2.33731914
153corticosteroid receptor signaling pathway (GO:0031958)2.33704108
154regulation of RNA stability (GO:0043487)2.33069689
155epithelial tube formation (GO:0072175)2.32617100
156positive regulation of protein deacetylation (GO:0090312)2.32411529
157dosage compensation (GO:0007549)2.31750266
158postsynaptic membrane organization (GO:0001941)2.31389691
159cellular response to interleukin-15 (GO:0071350)2.30799996
160translational termination (GO:0006415)2.30727736
161interkinetic nuclear migration (GO:0022027)2.30578782
162peptidyl-threonine dephosphorylation (GO:0035970)2.30572625
163histone H3-K9 modification (GO:0061647)2.30558538
164T cell differentiation (GO:0030217)2.30372641
165acrosome assembly (GO:0001675)2.29776730
166regulation of collateral sprouting (GO:0048670)2.29577635
167auditory behavior (GO:0031223)2.28704295
168neuron recognition (GO:0008038)2.28254446
169mechanosensory behavior (GO:0007638)2.28117540
170sister chromatid cohesion (GO:0007062)2.27517601
171negative regulation of histone modification (GO:0031057)2.27326136
172DNA double-strand break processing (GO:0000729)2.27265316
173histone lysine methylation (GO:0034968)2.27141536
174RNA destabilization (GO:0050779)2.26744169
175negative regulation of neurotransmitter transport (GO:0051589)2.26546018
176microtubule depolymerization (GO:0007019)2.26099224
177regulation of pigment cell differentiation (GO:0050932)2.26098695
178glutamate receptor signaling pathway (GO:0007215)2.26075316
179nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.25377915
180neural tube formation (GO:0001841)2.24141013
181regulation of histone methylation (GO:0031060)2.22222598
182negative regulation of T cell mediated immunity (GO:0002710)2.22181041

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.96861445
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.16043353
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.17050766
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13998326
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95647388
6EZH2_22144423_ChIP-Seq_EOC_Human3.79361124
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.76473758
8IGF1R_20145208_ChIP-Seq_DFB_Human3.67817426
9MYC_22102868_ChIP-Seq_BL_Human3.64885030
10SCL_19346495_ChIP-Seq_HPC-7_Human3.23601035
11ZNF274_21170338_ChIP-Seq_K562_Hela3.19333279
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.08963939
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99589003
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76852015
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72400062
16TAF15_26573619_Chip-Seq_HEK293_Human2.72260421
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70504604
18GBX2_23144817_ChIP-Seq_PC3_Human2.69084889
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.60265784
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56739014
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49638397
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49199453
23VDR_21846776_ChIP-Seq_THP-1_Human2.47295849
24FUS_26573619_Chip-Seq_HEK293_Human2.41047570
25VDR_22108803_ChIP-Seq_LS180_Human2.40477681
26* MYB_26560356_Chip-Seq_TH2_Human2.39155775
27RUNX_20019798_ChIP-Seq_JUKART_Human2.38683004
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38636925
29EWS_26573619_Chip-Seq_HEK293_Human2.36982414
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35550942
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.29736200
32* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23575098
33* MYB_26560356_Chip-Seq_TH1_Human2.13862273
34MAF_26560356_Chip-Seq_TH1_Human2.13432065
35SALL1_21062744_ChIP-ChIP_HESCs_Human2.06528130
36UTX_26944678_Chip-Seq_JUKART_Human2.04487686
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00604067
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99768276
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97533171
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95259779
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93952190
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93028367
43VDR_24763502_ChIP-Seq_THP-1_Human1.92996640
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92490594
45* P300_19829295_ChIP-Seq_ESCs_Human1.89279433
46IRF1_19129219_ChIP-ChIP_H3396_Human1.86369070
47* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84493968
48* ER_23166858_ChIP-Seq_MCF-7_Human1.82757980
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78260425
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76495424
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74785269
52RNF2_27304074_Chip-Seq_NSC_Mouse1.74499690
53CIITA_25753668_ChIP-Seq_RAJI_Human1.73196600
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.73152404
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72792719
56* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71857353
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70150521
58* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69819941
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69658827
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68729795
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66958723
62GATA1_22025678_ChIP-Seq_K562_Human1.66910933
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65889497
64* KDM2B_26808549_Chip-Seq_DND41_Human1.63861799
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63033179
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62365475
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61494531
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61494531
69GATA3_27048872_Chip-Seq_THYMUS_Human1.61270486
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.61084279
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60853546
72SMAD4_21799915_ChIP-Seq_A2780_Human1.56669432
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55716412
74* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54238300
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.53648215
76* SPI1_23547873_ChIP-Seq_NB4_Human1.51572073
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50506672
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50066491
79* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49506037
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49199601
81REST_21632747_ChIP-Seq_MESCs_Mouse1.48964594
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46902688
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46384311
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46021285
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45527465
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.44940759
87CBP_20019798_ChIP-Seq_JUKART_Human1.44350291
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44350291
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41206972
90STAT3_23295773_ChIP-Seq_U87_Human1.40693660
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.37029221
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36654346
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36300623
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35336035
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.34603762
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.34196207
97TCF4_23295773_ChIP-Seq_U87_Human1.33166522
98* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32593745
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32533732
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30333510
101BCAT_22108803_ChIP-Seq_LS180_Human1.28759212
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.28197118
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.27810247
104* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27702958
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27688880
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26239676
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25514202
108PU_27001747_Chip-Seq_BMDM_Mouse1.25318252
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.24579915
110* VDR_23849224_ChIP-Seq_CD4+_Human1.24359286
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23605827
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22777254
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22597282
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.21849431
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21478838
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20723119
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19445341
118* SPI1_23127762_ChIP-Seq_K562_Human1.19324926
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.17328196
120TP53_22573176_ChIP-Seq_HFKS_Human1.17088080
121AR_25329375_ChIP-Seq_VCAP_Human1.16753280
122* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16233772
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16200353
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15680634
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.14932129
126ETS1_22383799_ChIP-Seq_G1ME_Mouse1.14870575
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14130880
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.13985611
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13117786
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11972084
131* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11900435
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11574210
133* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11249277
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10200528
135RUNX2_22187159_ChIP-Seq_PCA_Human1.08798612
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06868958
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06494685
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05422043
139REST_18959480_ChIP-ChIP_MESCs_Mouse1.05221122
140* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05200462
141AR_21572438_ChIP-Seq_LNCaP_Human1.05074130
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03996505
143* MAF_26560356_Chip-Seq_TH2_Human1.03501140
144P53_22387025_ChIP-Seq_ESCs_Mouse1.03498020
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03392942
146SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01770012
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01507411
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99289457
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98175953
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.97742600
151MYC_18940864_ChIP-ChIP_HL60_Human0.97352362
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97190358
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96628446
154TCF4_22108803_ChIP-Seq_LS180_Human0.95442889
155* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95242591
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93442931
157EZH2_27304074_Chip-Seq_ESCs_Mouse0.93089108
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92637732
159FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92224678
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.92166180
161PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91574652
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.91454088
163* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90178225
164HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89478010
165* NCOR1_26117541_ChIP-Seq_K562_Human0.89299392
166SMAD_19615063_ChIP-ChIP_OVARY_Human0.87973553
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87123828
168RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86121853
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85595588
170ELK1_19687146_ChIP-ChIP_HELA_Human0.81252543
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80848051
172NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80667319
173KDM5A_27292631_Chip-Seq_BREAST_Human0.80373986
174ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80018436
175GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79529527
176GATA1_19941826_ChIP-Seq_K562_Human0.79290401
177PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78492096
178YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77289881
179ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76213789
180GATA3_26560356_Chip-Seq_TH2_Human0.75039802
181NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75023038
182* CHD1_26751641_Chip-Seq_LNCaP_Human0.73920803
183VDR_24787735_ChIP-Seq_THP-1_Human0.73539819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.30794952
2MP0003303_peritoneal_inflammation3.25299661
3MP0004808_abnormal_hematopoietic_stem2.91955769
4MP0000569_abnormal_digit_pigmentation2.83808061
5MP0003763_abnormal_thymus_physiology2.77008091
6MP0002166_altered_tumor_susceptibility2.55108043
7MP0005671_abnormal_response_to2.50009180
8MP0002396_abnormal_hematopoietic_system2.49356440
9MP0005174_abnormal_tail_pigmentation2.39973309
10MP0005076_abnormal_cell_differentiation2.32195915
11MP0002398_abnormal_bone_marrow2.26530382
12MP0005645_abnormal_hypothalamus_physiol2.23389354
13MP0000778_abnormal_nervous_system2.22157853
14MP0003300_gastrointestinal_ulcer2.18344227
15MP0001800_abnormal_humoral_immune2.10319374
16MP0001529_abnormal_vocalization2.10095417
17MP0008057_abnormal_DNA_replication2.09244888
18MP0002009_preneoplasia2.06031808
19MP0006054_spinal_hemorrhage2.04994462
20MP0000703_abnormal_thymus_morphology2.00817715
21MP0005423_abnormal_somatic_nervous1.95311707
22MP0001835_abnormal_antigen_presentation1.94829617
23MP0002006_tumorigenesis1.90377993
24MP0010352_gastrointestinal_tract_polyps1.85971014
25MP0010094_abnormal_chromosome_stability1.85221043
26MP0002420_abnormal_adaptive_immunity1.84587563
27MP0003787_abnormal_imprinting1.83278354
28MP0001819_abnormal_immune_cell1.81404443
29MP0002638_abnormal_pupillary_reflex1.78686884
30MP0002452_abnormal_antigen_presenting1.76676045
31MP0000716_abnormal_immune_system1.76269825
32MP0003122_maternal_imprinting1.76088619
33MP0004142_abnormal_muscle_tone1.75847629
34MP0005000_abnormal_immune_tolerance1.75405662
35MP0002722_abnormal_immune_system1.72435831
36MP0005397_hematopoietic_system_phenotyp1.71908399
37MP0001545_abnormal_hematopoietic_system1.71908399
38MP0006276_abnormal_autonomic_nervous1.70714219
39MP0002723_abnormal_immune_serum1.70418025
40MP0003436_decreased_susceptibility_to1.69164606
41MP0000685_abnormal_immune_system1.66633077
42MP0005387_immune_system_phenotype1.65038747
43MP0001790_abnormal_immune_system1.65038747
44MP0000689_abnormal_spleen_morphology1.62894501
45MP0002822_catalepsy1.61714932
46MP0001968_abnormal_touch/_nociception1.60807751
47MP0003635_abnormal_synaptic_transmissio1.60122165
48MP0000631_abnormal_neuroendocrine_gland1.59445077
49MP0002095_abnormal_skin_pigmentation1.58450186
50MP0001188_hyperpigmentation1.56656522
51MP0001984_abnormal_olfaction1.55622366
52MP0003077_abnormal_cell_cycle1.55300332
53MP0002405_respiratory_system_inflammati1.55000997
54MP0005464_abnormal_platelet_physiology1.54281210
55MP0002877_abnormal_melanocyte_morpholog1.52845987
56MP0002429_abnormal_blood_cell1.52552256
57MP0001486_abnormal_startle_reflex1.51521007
58MP0004742_abnormal_vestibular_system1.51429283
59MP0010155_abnormal_intestine_physiology1.51348766
60MP0005646_abnormal_pituitary_gland1.51018143
61MP0009745_abnormal_behavioral_response1.49779120
62MP0010234_abnormal_vibrissa_follicle1.47957241
63MP0000015_abnormal_ear_pigmentation1.46027431
64MP0003111_abnormal_nucleus_morphology1.44256254
65MP0000490_abnormal_crypts_of1.43557689
66MP0009785_altered_susceptibility_to1.43551915
67MP0006072_abnormal_retinal_apoptosis1.43319759
68MP0008995_early_reproductive_senescence1.43263356
69MP0005025_abnormal_response_to1.42734569
70MP0005084_abnormal_gallbladder_morpholo1.41131959
71MP0009046_muscle_twitch1.40338884
72MP0002063_abnormal_learning/memory/cond1.40259473
73MP0009278_abnormal_bone_marrow1.38838839
74MP0000465_gastrointestinal_hemorrhage1.38779268
75MP0002735_abnormal_chemical_nociception1.37317127
76MP0010307_abnormal_tumor_latency1.36380246
77MP0005394_taste/olfaction_phenotype1.36174082
78MP0005499_abnormal_olfactory_system1.36174082
79MP0002272_abnormal_nervous_system1.32619992
80MP0002277_abnormal_respiratory_mucosa1.31982193
81MP0003866_abnormal_defecation1.31130741
82MP0005253_abnormal_eye_physiology1.30711631
83MP0002572_abnormal_emotion/affect_behav1.30473527
84MP0002184_abnormal_innervation1.30275263
85MP0004270_analgesia1.27389459
86MP0004924_abnormal_behavior1.26913121
87MP0005386_behavior/neurological_phenoty1.26913121
88MP0002751_abnormal_autonomic_nervous1.26188872
89MP0002067_abnormal_sensory_capabilities1.25091394
90MP0005410_abnormal_fertilization1.24412366
91MP0009333_abnormal_splenocyte_physiolog1.23481303
92MP0002736_abnormal_nociception_after1.22543909
93MP0008877_abnormal_DNA_methylation1.21967761
94MP0008789_abnormal_olfactory_epithelium1.21802202
95MP0000537_abnormal_urethra_morphology1.21602069
96MP0002419_abnormal_innate_immunity1.21178605
97MP0002064_seizures1.20429339
98MP0005075_abnormal_melanosome_morpholog1.20343080
99MP0002557_abnormal_social/conspecific_i1.19986204
100MP0008007_abnormal_cellular_replicative1.17412272
101MP0000350_abnormal_cell_proliferation1.16449127
102MP0005367_renal/urinary_system_phenotyp1.15790615
103MP0000516_abnormal_urinary_system1.15790615
104MP0003943_abnormal_hepatobiliary_system1.13272985
105MP0002102_abnormal_ear_morphology1.13117598
106MP0004885_abnormal_endolymph1.12861054
107MP0003221_abnormal_cardiomyocyte_apopto1.12136427
108MP0001293_anophthalmia1.10526351
109MP0005551_abnormal_eye_electrophysiolog1.09549299
110MP0002019_abnormal_tumor_incidence1.07986947
111MP0008058_abnormal_DNA_repair1.07223376
112MP0002148_abnormal_hypersensitivity_rea1.07097780
113MP0004811_abnormal_neuron_physiology1.05272500
114MP0000955_abnormal_spinal_cord1.04776232
115MP0004947_skin_inflammation1.03824635
116MP0002928_abnormal_bile_duct1.02117736
117MP0003121_genomic_imprinting1.01706219
118MP0001851_eye_inflammation1.01080505
119MP0002909_abnormal_adrenal_gland1.00217975
120MP0001873_stomach_inflammation1.00093635
121MP0002882_abnormal_neuron_morphology0.99432934
122MP0000372_irregular_coat_pigmentation0.98536891
123MP0002734_abnormal_mechanical_nocicepti0.98334156
124MP0001845_abnormal_inflammatory_respons0.98029933
125MP0004133_heterotaxia0.96925290
126MP0004147_increased_porphyrin_level0.95693735
127MP0004859_abnormal_synaptic_plasticity0.92085233
128MP0002152_abnormal_brain_morphology0.91917000
129MP0000371_diluted_coat_color0.89299418
130MP0003890_abnormal_embryonic-extraembry0.89255944
131MP0004145_abnormal_muscle_electrophysio0.88202518
132MP0002752_abnormal_somatic_nervous0.87295803
133MP0001970_abnormal_pain_threshold0.86871240
134MP0002086_abnormal_extraembryonic_tissu0.85888086
135MP0000313_abnormal_cell_death0.83030322
136MP0003567_abnormal_fetal_cardiomyocyte0.81575213
137MP0008961_abnormal_basal_metabolism0.81504432
138MP0003172_abnormal_lysosome_physiology0.81414407
139MP0002075_abnormal_coat/hair_pigmentati0.80708236
140MP0003698_abnormal_male_reproductive0.80330973
141MP0002084_abnormal_developmental_patter0.80166219
142MP0003938_abnormal_ear_development0.80154401
143MP0000383_abnormal_hair_follicle0.79551027
144MP0004197_abnormal_fetal_growth/weight/0.79438568
145MP0006292_abnormal_olfactory_placode0.79185168
146MP0001348_abnormal_lacrimal_gland0.78661263
147MP0000858_altered_metastatic_potential0.78069830
148MP0008872_abnormal_physiological_respon0.77515250
149MP0002160_abnormal_reproductive_system0.77497418
150MP0002733_abnormal_thermal_nociception0.75777492
151MP0003861_abnormal_nervous_system0.75359708
152MP0000427_abnormal_hair_cycle0.74540431
153MP0002210_abnormal_sex_determination0.74438596
154MP0001697_abnormal_embryo_size0.74426759
155MP0002925_abnormal_cardiovascular_devel0.74203809
156MP0003448_altered_tumor_morphology0.73987584
157MP0001502_abnormal_circadian_rhythm0.73923015
158MP0001915_intracranial_hemorrhage0.72841252
159MP0009703_decreased_birth_body0.72475472
160MP0001929_abnormal_gametogenesis0.72301975
161MP0005409_darkened_coat_color0.72012413
162MP0008770_decreased_survivor_rate0.71842396
163MP0002088_abnormal_embryonic_growth/wei0.71485319
164MP0001905_abnormal_dopamine_level0.71482778
165MP0003045_fibrosis0.71338732
166MP0005187_abnormal_penis_morphology0.71327546
167MP0003984_embryonic_growth_retardation0.70109777
168MP0000647_abnormal_sebaceous_gland0.69371029
169MP0005391_vision/eye_phenotype0.68984450
170MP0003693_abnormal_embryo_hatching0.68475127
171MP0004484_altered_response_of0.68421626
172MP0000733_abnormal_muscle_development0.68067358
173MP0002092_abnormal_eye_morphology0.67866682
174MP0001986_abnormal_taste_sensitivity0.67599539

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.27710410
2Volvulus (HP:0002580)3.83837486
3Hyperventilation (HP:0002883)3.70147553
4Thrombocytosis (HP:0001894)3.58565537
5Type II lissencephaly (HP:0007260)3.27685944
6Medial flaring of the eyebrow (HP:0010747)3.16284822
7Retinal dysplasia (HP:0007973)3.07801150
8Gait imbalance (HP:0002141)3.07130949
9B lymphocytopenia (HP:0010976)2.95403001
10Abnormality of B cell number (HP:0010975)2.95403001
11Recurrent viral infections (HP:0004429)2.93926065
12Pancreatic cysts (HP:0001737)2.90004140
13Congenital primary aphakia (HP:0007707)2.86559270
14Febrile seizures (HP:0002373)2.83204449
15Drooling (HP:0002307)2.83118707
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80889234
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.80889234
18Nasal polyposis (HP:0100582)2.80715705
19Myositis (HP:0100614)2.78281272
20Recurrent fungal infections (HP:0002841)2.77792582
21Excessive salivation (HP:0003781)2.74817438
22Nephrogenic diabetes insipidus (HP:0009806)2.70385885
23Panhypogammaglobulinemia (HP:0003139)2.67583653
24Focal motor seizures (HP:0011153)2.65671675
25Recurrent bronchitis (HP:0002837)2.65087676
26Thyroiditis (HP:0100646)2.64877120
27Chronic otitis media (HP:0000389)2.60988041
28Absent frontal sinuses (HP:0002688)2.58924574
29Lissencephaly (HP:0001339)2.58896146
30IgM deficiency (HP:0002850)2.57968283
31Nephronophthisis (HP:0000090)2.53342654
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.49622777
33Pancreatic fibrosis (HP:0100732)2.49409912
34T lymphocytopenia (HP:0005403)2.47999282
35Abnormality of the nasal mucosa (HP:0000433)2.43941080
36Short 4th metacarpal (HP:0010044)2.42750263
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42750263
38Molar tooth sign on MRI (HP:0002419)2.41976058
39Abnormality of midbrain morphology (HP:0002418)2.41976058
40Acute myeloid leukemia (HP:0004808)2.41213971
41Macroorchidism (HP:0000053)2.40656352
42Hyperacusis (HP:0010780)2.40617780
43Gastrointestinal inflammation (HP:0004386)2.40411294
44True hermaphroditism (HP:0010459)2.40054543
45Eczematoid dermatitis (HP:0000976)2.39554488
46Inflammation of the large intestine (HP:0002037)2.38384377
47Chest pain (HP:0100749)2.37886455
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37424729
49Absent speech (HP:0001344)2.36746648
50Stomatitis (HP:0010280)2.34849367
51Basal cell carcinoma (HP:0002671)2.34147074
52Limb dystonia (HP:0002451)2.33979063
53Subacute progressive viral hepatitis (HP:0006572)2.32941626
54Long eyelashes (HP:0000527)2.32786728
55Colitis (HP:0002583)2.30678188
56Heterotopia (HP:0002282)2.29652506
57Viral hepatitis (HP:0006562)2.28941846
58Recurrent cutaneous fungal infections (HP:0011370)2.26318725
59Chronic mucocutaneous candidiasis (HP:0002728)2.26318725
60Abnormality of the corticospinal tract (HP:0002492)2.25940050
61Abnormality of T cell number (HP:0011839)2.24797505
62Pachygyria (HP:0001302)2.24778921
63Genital tract atresia (HP:0001827)2.24535811
64Oligodactyly (hands) (HP:0001180)2.23712478
65Recurrent abscess formation (HP:0002722)2.22885130
66Cellulitis (HP:0100658)2.22285013
67Chronic hepatic failure (HP:0100626)2.21892981
68Hypothermia (HP:0002045)2.20432367
69Amaurosis fugax (HP:0100576)2.19913024
70Abnormality of the renal medulla (HP:0100957)2.19026287
71Meningitis (HP:0001287)2.18578394
72Recurrent bacterial skin infections (HP:0005406)2.17585988
73Prominent nose (HP:0000448)2.16824963
74Arterial thrombosis (HP:0004420)2.16277191
75Papillary thyroid carcinoma (HP:0002895)2.16142401
76Agammaglobulinemia (HP:0004432)2.14811400
77Vaginal atresia (HP:0000148)2.13501007
78Poor coordination (HP:0002370)2.13166084
79Widely spaced teeth (HP:0000687)2.12133436
80Cortical dysplasia (HP:0002539)2.12130497
81Abnormality of T cells (HP:0002843)2.12106607
82Abolished electroretinogram (ERG) (HP:0000550)2.09593442
83Lip pit (HP:0100267)2.06377126
84Spinal cord lesions (HP:0100561)2.05773235
85Syringomyelia (HP:0003396)2.05773235
86Lymphopenia (HP:0001888)2.05292433
87Thyroid-stimulating hormone excess (HP:0002925)2.04746835
88Amyotrophic lateral sclerosis (HP:0007354)2.03640665
89Chronic obstructive pulmonary disease (HP:0006510)2.03613795
90Obstructive lung disease (HP:0006536)2.03613795
91Increased density of long bones (HP:0006392)2.02632207
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.02555849
93Progressive cerebellar ataxia (HP:0002073)2.02193978
94Mediastinal lymphadenopathy (HP:0100721)2.01993876
95Aplasia/Hypoplasia of the tibia (HP:0005772)2.01867517
96Inability to walk (HP:0002540)2.01650888
973-Methylglutaconic aciduria (HP:0003535)2.00315633
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99575914
99Abnormality of the labia minora (HP:0012880)1.98860778
100Cupped ear (HP:0000378)1.98834935
101Severe combined immunodeficiency (HP:0004430)1.97296234
102Medulloblastoma (HP:0002885)1.95147546
103Intestinal atresia (HP:0011100)1.94694508
104Gastrointestinal infarctions (HP:0005244)1.94434564
105Cerebellar dysplasia (HP:0007033)1.91780274
106Broad-based gait (HP:0002136)1.91257320
107Obsessive-compulsive behavior (HP:0000722)1.90548811
108Bronchitis (HP:0012387)1.90403378
109Stomach cancer (HP:0012126)1.89491304
110Thyroid carcinoma (HP:0002890)1.89486724
111Short tibia (HP:0005736)1.89059555
112Specific learning disability (HP:0001328)1.89032858
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88502654
114Genetic anticipation (HP:0003743)1.88366276
115Hypochromic anemia (HP:0001931)1.87211986
116Broad palm (HP:0001169)1.87071095
117Abnormality of the renal cortex (HP:0011035)1.86853105
118Dislocated radial head (HP:0003083)1.86640838
119Narrow forehead (HP:0000341)1.86100707
120Growth hormone deficiency (HP:0000824)1.85711515
121Cutis marmorata (HP:0000965)1.85669586
122Tented upper lip vermilion (HP:0010804)1.84733988
123Methylmalonic acidemia (HP:0002912)1.83550459
124Recurrent sinusitis (HP:0011108)1.82437768
125Agitation (HP:0000713)1.81894367
126Truncal obesity (HP:0001956)1.80604304
127Decreased central vision (HP:0007663)1.79837262
128Retrobulbar optic neuritis (HP:0100654)1.79283116
129Optic neuritis (HP:0100653)1.79283116
130Epileptic encephalopathy (HP:0200134)1.79237288
131Abnormality of T cell physiology (HP:0011840)1.79102755
132Narrow palate (HP:0000189)1.78762367
133Rectal prolapse (HP:0002035)1.78500301
134Congenital stationary night blindness (HP:0007642)1.77728679
135Abnormality of salivation (HP:0100755)1.77369631
136Hypoplasia of the thymus (HP:0000778)1.76909613
137Vasculitis (HP:0002633)1.76784916
138Hematochezia (HP:0002573)1.76706339
139Abnormality of ocular smooth pursuit (HP:0000617)1.76534093
140Tubulointerstitial nephritis (HP:0001970)1.76317971
141Elevated erythrocyte sedimentation rate (HP:0003565)1.76186063
142Impaired smooth pursuit (HP:0007772)1.75166851
143Polyphagia (HP:0002591)1.75064724
144Abnormal rod and cone electroretinograms (HP:0008323)1.74931660
145Hypoplastic iliac wings (HP:0002866)1.74922298
146Papilledema (HP:0001085)1.74740476
147Bicuspid aortic valve (HP:0001647)1.73940340
148Gaze-evoked nystagmus (HP:0000640)1.73272682
149Supernumerary spleens (HP:0009799)1.73265813
150Neoplasm of the oral cavity (HP:0100649)1.72455108
151Abnormality of eosinophils (HP:0001879)1.72374626
152Postaxial hand polydactyly (HP:0001162)1.72211122
153Abnormality of the radial head (HP:0003995)1.71432850
154Atonic seizures (HP:0010819)1.71376100
155Morphological abnormality of the pyramidal tract (HP:0002062)1.71211208
156Protruding tongue (HP:0010808)1.70994535
157Prominent nasal bridge (HP:0000426)1.70606408
158Eosinophilia (HP:0001880)1.70402846
159Inappropriate behavior (HP:0000719)1.70221132
160Focal seizures (HP:0007359)1.70180345
161Hip dysplasia (HP:0001385)1.69946827
162Recurrent skin infections (HP:0001581)1.69751435
163Transitional cell carcinoma of the bladder (HP:0006740)1.69664547
164Optic nerve coloboma (HP:0000588)1.68907988
165Lymphoma (HP:0002665)1.68451305
166Gastrointestinal stroma tumor (HP:0100723)1.68404659
167Increased nuchal translucency (HP:0010880)1.68365356
168Combined immunodeficiency (HP:0005387)1.68137239
169Poor eye contact (HP:0000817)1.66497941
170Myelodysplasia (HP:0002863)1.65836573
171Thick eyebrow (HP:0000574)1.65133443
172Hepatoblastoma (HP:0002884)1.64758425
173Hemoptysis (HP:0002105)1.64665802
174Broad foot (HP:0001769)1.64612424
175Colon cancer (HP:0003003)1.64282965
176Progressive inability to walk (HP:0002505)1.63286230
177Intellectual disability, severe (HP:0010864)1.63199777
178Tapered finger (HP:0001182)1.62830905
17911 pairs of ribs (HP:0000878)1.62540119
180Gastrointestinal carcinoma (HP:0002672)1.62271701
181Renal cortical cysts (HP:0000803)1.59633252
182Cystic liver disease (HP:0006706)1.59108821
183Polymicrogyria (HP:0002126)1.57995792
184Dyskinesia (HP:0100660)1.57963755
185Dandy-Walker malformation (HP:0001305)1.57650751
186Optic nerve hypoplasia (HP:0000609)1.57115217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.54603774
2EEF2K3.04439521
3MAP3K42.88985924
4CDK122.78440537
5MAPK132.52565225
6MAP4K22.46379552
7TXK2.41922739
8FRK2.41118599
9CASK2.30008133
10CAMKK22.19989932
11PKN22.15200384
12WNK32.13127009
13CDK192.12029746
14TRIM282.04206334
15BCR2.02179829
16MAP3K102.01479946
17NEK21.97751628
18BTK1.95686827
19CCNB11.92581514
20ITK1.91660246
21SIK21.91644673
22DYRK21.89527761
23PNCK1.89070579
24TEC1.80691164
25STK101.78559532
26BRD41.77543002
27NTRK21.76854816
28TGFBR11.75228845
29JAK31.74745936
30TGFBR21.71912182
31ERBB31.67689191
32MAP2K71.64196741
33HIPK21.62067678
34SCYL21.47742515
35TAOK31.47619050
36ZAP701.47516663
37CDK61.46553482
38CSNK1G21.45716212
39FGFR31.44123427
40STK31.43452971
41CDC71.42395406
42PINK11.40180998
43MAP3K61.38842579
44LRRK21.34542296
45MAP2K41.33343237
46LCK1.31430165
47HCK1.28695781
48MAP3K141.23170897
49MARK11.22920941
50ALK1.18967864
51SYK1.18256738
52GRK61.16587212
53CSF1R1.12734411
54PDGFRB1.10745507
55PASK1.10742929
56CDK91.10639253
57KIT1.09305284
58CHUK1.08897220
59JAK11.05528535
60FES1.05298740
61DYRK31.05201782
62ADRBK21.02827037
63PIM11.02172263
64ATR1.01776047
65SGK21.00585819
66TLK10.98586496
67TBK10.97356498
68TAOK10.95761490
69ZAK0.94588187
70NUAK10.93951863
71YES10.93619593
72PTK60.92927823
73IRAK40.92621888
74RET0.90223568
75CSNK1G30.90213766
76IKBKE0.90063603
77MAP2K30.89707155
78RIPK10.87764801
79PAK30.86914857
80KSR10.86117289
81TAF10.84845802
82CAMK1G0.84509629
83MINK10.82413839
84CSNK1G10.82234668
85SRPK10.80014290
86DYRK1A0.79912138
87CAMKK10.79230255
88SGK2230.77830269
89SGK4940.77830269
90FGFR10.76337892
91RPS6KB20.76087217
92STK110.74070868
93SIK30.73364045
94ATM0.73241037
95CDK30.72989159
96RPS6KB10.71918324
97MARK30.70875662
98IRAK10.70521318
99RPS6KA40.69965733
100FLT30.69555068
101CSK0.68670879
102CHEK10.67321454
103ACVR1B0.66526190
104NTRK30.66340713
105RPS6KA50.65133508
106RIPK40.64791668
107EPHA40.64186963
108LYN0.63886311
109JAK20.63743335
110CAMK1D0.62022439
111IKBKB0.61652865
112GRK10.61300586
113MARK20.60192697
114TESK10.59366791
115TNIK0.58913534
116MKNK20.58332985
117OXSR10.58192954
118MKNK10.57995822
119BCKDK0.57236228
120EPHA30.56994031
121CLK10.55619409
122TYK20.55190795
123DYRK1B0.53928918
124SGK30.53177490
125NLK0.52928678
126CSNK1D0.52709120
127CDK20.52540499
128PDGFRA0.51945956
129BRSK20.51653056
130CHEK20.51090588
131STK240.50854150
132PDK10.50523585
133MTOR0.50080532
134CAMK40.49652085
135PRKCQ0.49334341
136PRKCE0.47524049
137BMPR1B0.46973216
138VRK10.46512643
139RPS6KA20.46362396
140SGK10.46233046
141UHMK10.44624466
142ICK0.43374817
143MAPK140.42583136
144EIF2AK20.42572754
145PRKCG0.42560742
146LATS10.42140540
147CSNK1A1L0.41488200
148PRKCZ0.41457628
149FGFR20.41129132
150PLK20.38442148
151PRKG10.37816837
152CDK50.36638108
153PRKAA10.36047059
154MAP2K60.35162289
155PKN10.34296992
156CAMK2A0.33718215
157DAPK20.32595492
158CAMK10.31129549

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01736276
2Primary immunodeficiency_Homo sapiens_hsa053402.14213009
3B cell receptor signaling pathway_Homo sapiens_hsa046621.88882196
4Regulation of autophagy_Homo sapiens_hsa041401.72102524
5GABAergic synapse_Homo sapiens_hsa047271.71457588
6Morphine addiction_Homo sapiens_hsa050321.71293345
7Basal transcription factors_Homo sapiens_hsa030221.68658958
8T cell receptor signaling pathway_Homo sapiens_hsa046601.68619024
9Leishmaniasis_Homo sapiens_hsa051401.63995971
10Taste transduction_Homo sapiens_hsa047421.62595151
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62321685
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61402973
13Glutamatergic synapse_Homo sapiens_hsa047241.60846812
14Dopaminergic synapse_Homo sapiens_hsa047281.57593860
15Osteoclast differentiation_Homo sapiens_hsa043801.55031894
16Protein export_Homo sapiens_hsa030601.51770811
17Measles_Homo sapiens_hsa051621.51561129
18Antigen processing and presentation_Homo sapiens_hsa046121.51313267
19Long-term depression_Homo sapiens_hsa047301.49911186
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49457382
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48223832
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47848029
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.46220653
24Circadian entrainment_Homo sapiens_hsa047131.44845401
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41694584
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40546198
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39791489
28Amphetamine addiction_Homo sapiens_hsa050311.39355926
29Cocaine addiction_Homo sapiens_hsa050301.38712226
30Chronic myeloid leukemia_Homo sapiens_hsa052201.38509493
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36780791
32Circadian rhythm_Homo sapiens_hsa047101.35121400
33Olfactory transduction_Homo sapiens_hsa047401.33382040
34Herpes simplex infection_Homo sapiens_hsa051681.28843851
35Systemic lupus erythematosus_Homo sapiens_hsa053221.25491879
36mTOR signaling pathway_Homo sapiens_hsa041501.21629198
37mRNA surveillance pathway_Homo sapiens_hsa030151.20850898
38Colorectal cancer_Homo sapiens_hsa052101.20472268
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20165951
40Type I diabetes mellitus_Homo sapiens_hsa049401.20058842
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.19438552
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.19160802
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.18736455
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18542474
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17274658
46Cholinergic synapse_Homo sapiens_hsa047251.16686722
47Acute myeloid leukemia_Homo sapiens_hsa052211.16586921
48Toxoplasmosis_Homo sapiens_hsa051451.16135258
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14941749
50Ether lipid metabolism_Homo sapiens_hsa005651.14540183
51Hematopoietic cell lineage_Homo sapiens_hsa046401.13237995
52Chemokine signaling pathway_Homo sapiens_hsa040621.12502253
53Hepatitis B_Homo sapiens_hsa051611.12248115
54TNF signaling pathway_Homo sapiens_hsa046681.11749282
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11509059
56Viral carcinogenesis_Homo sapiens_hsa052031.09211050
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.08803891
58Platelet activation_Homo sapiens_hsa046111.03228918
59Viral myocarditis_Homo sapiens_hsa054161.02597703
60Asthma_Homo sapiens_hsa053101.02266162
61Serotonergic synapse_Homo sapiens_hsa047261.01011812
62Autoimmune thyroid disease_Homo sapiens_hsa053201.00895714
63Non-small cell lung cancer_Homo sapiens_hsa052231.00537240
64Butanoate metabolism_Homo sapiens_hsa006500.99127190
65Influenza A_Homo sapiens_hsa051640.99042529
66MicroRNAs in cancer_Homo sapiens_hsa052060.98799849
67Spliceosome_Homo sapiens_hsa030400.98513273
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98472959
69HTLV-I infection_Homo sapiens_hsa051660.97786126
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.96969711
71Pancreatic cancer_Homo sapiens_hsa052120.96760722
72DNA replication_Homo sapiens_hsa030300.96558676
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95415387
74Alcoholism_Homo sapiens_hsa050340.93652383
75Long-term potentiation_Homo sapiens_hsa047200.92663944
76Small cell lung cancer_Homo sapiens_hsa052220.92341417
77Cell cycle_Homo sapiens_hsa041100.91962936
78RNA polymerase_Homo sapiens_hsa030200.91941501
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90382063
80VEGF signaling pathway_Homo sapiens_hsa043700.89428968
81Axon guidance_Homo sapiens_hsa043600.89334490
82Prolactin signaling pathway_Homo sapiens_hsa049170.89243789
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87842113
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87452088
85Mismatch repair_Homo sapiens_hsa034300.87052578
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86255815
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85874766
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85798244
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85174865
90Nitrogen metabolism_Homo sapiens_hsa009100.85100149
91Endometrial cancer_Homo sapiens_hsa052130.84742987
92Legionellosis_Homo sapiens_hsa051340.82879371
93Shigellosis_Homo sapiens_hsa051310.82265777
94Linoleic acid metabolism_Homo sapiens_hsa005910.81030538
95Parkinsons disease_Homo sapiens_hsa050120.80821707
96Renin secretion_Homo sapiens_hsa049240.80443150
97Type II diabetes mellitus_Homo sapiens_hsa049300.79914375
98Graft-versus-host disease_Homo sapiens_hsa053320.78551292
99RNA degradation_Homo sapiens_hsa030180.78178892
100Apoptosis_Homo sapiens_hsa042100.77359964
101Epstein-Barr virus infection_Homo sapiens_hsa051690.76801325
102Non-homologous end-joining_Homo sapiens_hsa034500.76330484
103Oxytocin signaling pathway_Homo sapiens_hsa049210.74476516
104Tuberculosis_Homo sapiens_hsa051520.74052288
105RNA transport_Homo sapiens_hsa030130.73336634
106Thyroid cancer_Homo sapiens_hsa052160.72850327
107Glioma_Homo sapiens_hsa052140.71548141
108FoxO signaling pathway_Homo sapiens_hsa040680.71458847
109Gap junction_Homo sapiens_hsa045400.70897703
110Allograft rejection_Homo sapiens_hsa053300.70764117
111MAPK signaling pathway_Homo sapiens_hsa040100.70250274
112Inositol phosphate metabolism_Homo sapiens_hsa005620.69106486
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68911763
114cAMP signaling pathway_Homo sapiens_hsa040240.68439349
115Renal cell carcinoma_Homo sapiens_hsa052110.67652007
116Ribosome_Homo sapiens_hsa030100.67446752
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67393253
118Estrogen signaling pathway_Homo sapiens_hsa049150.67284181
119Salmonella infection_Homo sapiens_hsa051320.66867721
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66689216
121p53 signaling pathway_Homo sapiens_hsa041150.66374241
122Notch signaling pathway_Homo sapiens_hsa043300.65895638
123ErbB signaling pathway_Homo sapiens_hsa040120.65890967
124Oocyte meiosis_Homo sapiens_hsa041140.65725390
125Fanconi anemia pathway_Homo sapiens_hsa034600.65439007
126Proteoglycans in cancer_Homo sapiens_hsa052050.65219627
127Prostate cancer_Homo sapiens_hsa052150.64955106
128Salivary secretion_Homo sapiens_hsa049700.64632258
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62235039
130Oxidative phosphorylation_Homo sapiens_hsa001900.61997561
131Dorso-ventral axis formation_Homo sapiens_hsa043200.61541306
132N-Glycan biosynthesis_Homo sapiens_hsa005100.61318275
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61043774
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60953739
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60206596
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59788592
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.58905792
138Pathways in cancer_Homo sapiens_hsa052000.58322531
139Base excision repair_Homo sapiens_hsa034100.57892756
140Hepatitis C_Homo sapiens_hsa051600.57400680
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56921176
142Phototransduction_Homo sapiens_hsa047440.56180552
143Lysine degradation_Homo sapiens_hsa003100.55600680
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54634359
145Wnt signaling pathway_Homo sapiens_hsa043100.53978689
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53938226
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53498691
148Insulin secretion_Homo sapiens_hsa049110.50241407
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50074326
150Choline metabolism in cancer_Homo sapiens_hsa052310.48251516
151Calcium signaling pathway_Homo sapiens_hsa040200.47485218
152Peroxisome_Homo sapiens_hsa041460.47338061
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46424416
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45297024
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44985221
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44684231
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.42297850

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