RSBN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.81795057
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.77563505
3DNA deamination (GO:0045006)4.26650449
4regulation of gamma-delta T cell differentiation (GO:0045586)4.15752329
5regulation of gamma-delta T cell activation (GO:0046643)4.12764747
6neural tube formation (GO:0001841)3.80246432
7behavioral response to nicotine (GO:0035095)3.77688452
8interferon-gamma production (GO:0032609)3.72270525
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67281764
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67281764
11antigen processing and presentation of endogenous antigen (GO:0019883)3.64654830
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.62232626
13regulation of regulatory T cell differentiation (GO:0045589)3.59369833
14myeloid dendritic cell activation (GO:0001773)3.58901937
15regulation of B cell receptor signaling pathway (GO:0050855)3.54857174
16definitive hemopoiesis (GO:0060216)3.52178134
17negative regulation of telomere maintenance (GO:0032205)3.46021389
18defense response to protozoan (GO:0042832)3.43863086
19response to type I interferon (GO:0034340)3.39956236
20negative regulation of cell killing (GO:0031342)3.37454937
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37454937
22response to pheromone (GO:0019236)3.36330653
23type I interferon signaling pathway (GO:0060337)3.34510003
24cellular response to type I interferon (GO:0071357)3.34510003
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32838340
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32590273
27myeloid dendritic cell differentiation (GO:0043011)3.30178687
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29024476
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.29024476
30modulation by symbiont of host immune response (GO:0052553)3.29024476
31positive regulation by symbiont of host defense response (GO:0052509)3.29024476
32modulation by symbiont of host defense response (GO:0052031)3.29024476
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29024476
34regulation of telomere maintenance (GO:0032204)3.27766046
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26382270
36positive regulation of B cell differentiation (GO:0045579)3.25100231
37regulation of interleukin-12 biosynthetic process (GO:0045075)3.24051629
38T cell migration (GO:0072678)3.23268049
39protein K11-linked deubiquitination (GO:0035871)3.18579771
40neutrophil activation (GO:0042119)3.17674531
41response to protozoan (GO:0001562)3.17479592
42regulation of B cell differentiation (GO:0045577)3.16334660
43T cell homeostasis (GO:0043029)3.15273910
44protein polyglutamylation (GO:0018095)3.10070764
45immunoglobulin mediated immune response (GO:0016064)3.09027148
46megakaryocyte development (GO:0035855)3.07110164
47B cell receptor signaling pathway (GO:0050853)3.05276556
48establishment of protein localization to Golgi (GO:0072600)3.04909210
49regulation of DNA endoreduplication (GO:0032875)3.04219713
50rRNA catabolic process (GO:0016075)3.03260220
51mast cell activation (GO:0045576)3.01984147
52granulocyte activation (GO:0036230)3.00502487
53mature B cell differentiation (GO:0002335)2.99577758
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98908402
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.98908402
56regulation of translation, ncRNA-mediated (GO:0045974)2.98908402
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97720864
58positive regulation of interferon-alpha production (GO:0032727)2.97434254
59replication fork processing (GO:0031297)2.96954515
60positive regulation of interleukin-2 production (GO:0032743)2.96856899
61neutrophil activation involved in immune response (GO:0002283)2.96080120
62response to peptidoglycan (GO:0032494)2.95496628
63detection of light stimulus involved in visual perception (GO:0050908)2.93950929
64detection of light stimulus involved in sensory perception (GO:0050962)2.93950929
65L-fucose catabolic process (GO:0042355)2.91391003
66fucose catabolic process (GO:0019317)2.91391003
67L-fucose metabolic process (GO:0042354)2.91391003
68activated T cell proliferation (GO:0050798)2.91099142
69piRNA metabolic process (GO:0034587)2.87888318
70regulation of interferon-alpha production (GO:0032647)2.85429904
71positive regulation of humoral immune response (GO:0002922)2.85319793
72positive regulation of natural killer cell differentiation (GO:0032825)2.84910320
73interferon-gamma-mediated signaling pathway (GO:0060333)2.83973289
74negative T cell selection (GO:0043383)2.82521087
75antigen processing and presentation via MHC class Ib (GO:0002475)2.82038506
76response to interleukin-15 (GO:0070672)2.81777428
77regulation of alpha-beta T cell proliferation (GO:0046640)2.81562491
78NIK/NF-kappaB signaling (GO:0038061)2.80910854
79histone H3-K4 trimethylation (GO:0080182)2.79445232
80B cell proliferation (GO:0042100)2.79254055
81lymphocyte homeostasis (GO:0002260)2.79037546
82natural killer cell activation (GO:0030101)2.78826516
83cellular response to zinc ion (GO:0071294)2.78751504
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77922326
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76727606
86cardiovascular system development (GO:0072358)2.76187599
87protein targeting to Golgi (GO:0000042)2.76010659
88negative regulation of viral genome replication (GO:0045071)2.75369462
89leukocyte aggregation (GO:0070486)2.75333560
90regulation of interferon-beta biosynthetic process (GO:0045357)2.74929347
91B cell homeostasis (GO:0001782)2.74674837
92negative thymic T cell selection (GO:0045060)2.72977660
93positive regulation of defense response to virus by host (GO:0002230)2.72066939
94response to muramyl dipeptide (GO:0032495)2.71680277
95lymph node development (GO:0048535)2.71486224
96double-strand break repair via homologous recombination (GO:0000724)2.71324245
97recombinational repair (GO:0000725)2.70668679
98negative regulation of T cell mediated immunity (GO:0002710)2.70585996
99histone H3-K9 methylation (GO:0051567)2.70356400
100cellular response to interleukin-15 (GO:0071350)2.68837427
101male meiosis I (GO:0007141)2.68139101
102histone mRNA catabolic process (GO:0071044)2.67997909
103T-helper 1 type immune response (GO:0042088)2.67010261
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66109563
105protein-cofactor linkage (GO:0018065)2.65386144
106JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65095479
107regulation of germinal center formation (GO:0002634)2.64579752
108alpha-beta T cell activation (GO:0046631)2.64360181
109regulation of T cell receptor signaling pathway (GO:0050856)2.64119145
110positive regulation of isotype switching (GO:0045830)2.63903536
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63639933
112CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.63527373
113positive thymic T cell selection (GO:0045059)2.61948719
114response to interferon-alpha (GO:0035455)2.60993445
115positive regulation of immunoglobulin mediated immune response (GO:0002891)2.60152574
116positive regulation of B cell mediated immunity (GO:0002714)2.60152574
117positive regulation of DNA recombination (GO:0045911)2.59157791
118germinal center formation (GO:0002467)2.58551959
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58236456
120negative regulation of phagocytosis (GO:0050765)2.57782477
121positive regulation of interferon-beta production (GO:0032728)2.57164802
122positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56806840
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56581006
124myeloid cell activation involved in immune response (GO:0002275)2.55977319
125negative regulation of B cell proliferation (GO:0030889)2.55075227
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55066133
127dendritic cell differentiation (GO:0097028)2.54937143
128positive regulation of antigen processing and presentation (GO:0002579)2.54653011
129cellular response to interferon-beta (GO:0035458)2.54120505
130cell proliferation in forebrain (GO:0021846)2.53887835
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.53041052
132detection of other organism (GO:0098543)2.52914246
133leukocyte homeostasis (GO:0001776)2.50796508
134epithelial cilium movement (GO:0003351)2.50565134
135macrophage activation involved in immune response (GO:0002281)2.50421315
136myeloid leukocyte activation (GO:0002274)2.50222045
137positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49953508
138cornea development in camera-type eye (GO:0061303)2.49610689
139T-helper cell differentiation (GO:0042093)2.49399227
140DNA methylation involved in gamete generation (GO:0043046)2.48701069
141regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48183751
142preassembly of GPI anchor in ER membrane (GO:0016254)2.47916082
143DNA demethylation (GO:0080111)2.47177477
144embryonic epithelial tube formation (GO:0001838)2.46806881
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46653085
146somatic hypermutation of immunoglobulin genes (GO:0016446)2.45465246
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45465246
148histone H3-K9 modification (GO:0061647)2.45006786
149mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43825538
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.43825538
151NADH dehydrogenase complex assembly (GO:0010257)2.43825538
152indolalkylamine metabolic process (GO:0006586)2.43618866
153sulfation (GO:0051923)2.43574484
154centriole replication (GO:0007099)2.43108452
155mast cell degranulation (GO:0043303)2.41265407
156mast cell activation involved in immune response (GO:0002279)2.41265407
157peptidyl-lysine trimethylation (GO:0018023)2.38070743
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36742627
159indole-containing compound catabolic process (GO:0042436)2.35992083
160indolalkylamine catabolic process (GO:0046218)2.35992083
161tryptophan catabolic process (GO:0006569)2.35992083
162synapsis (GO:0007129)2.35493867
163microtubule anchoring (GO:0034453)2.35428541
164axoneme assembly (GO:0035082)2.34522784
165positive regulation of granulocyte differentiation (GO:0030854)2.33371225
166otic vesicle formation (GO:0030916)2.31759689
167DNA double-strand break processing (GO:0000729)2.31734802
168regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.31139189
169tachykinin receptor signaling pathway (GO:0007217)2.31083506
170protein localization to Golgi apparatus (GO:0034067)2.30975815
171interferon-gamma secretion (GO:0072643)2.30859580
172inositol phosphate catabolic process (GO:0071545)2.29624673
173monoubiquitinated protein deubiquitination (GO:0035520)2.28859071
174regulation of memory T cell differentiation (GO:0043380)2.28109140
175kidney morphogenesis (GO:0060993)2.27134587
176resolution of meiotic recombination intermediates (GO:0000712)2.26651445
177cytidine deamination (GO:0009972)2.26403921
178cytidine metabolic process (GO:0046087)2.26403921
179cytidine catabolic process (GO:0006216)2.26403921
180DNA modification (GO:0006304)2.26152643
181dentate gyrus development (GO:0021542)2.26059460
182protein complex biogenesis (GO:0070271)2.24521313
183ncRNA catabolic process (GO:0034661)2.24139724
184regulation of telomere maintenance via telomerase (GO:0032210)2.23920571
185regulation of mitotic spindle checkpoint (GO:1903504)2.23305743
186regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.23305743
187epithelial tube formation (GO:0072175)2.22852920
188membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22769702
189tryptophan metabolic process (GO:0006568)2.22645004
190regulation of action potential (GO:0098900)2.22621283
191interkinetic nuclear migration (GO:0022027)2.20532007
192somite development (GO:0061053)2.20318583
193regulation of establishment of cell polarity (GO:2000114)2.19419840
194DNA methylation or demethylation (GO:0044728)2.19098128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.83113680
2E2F7_22180533_ChIP-Seq_HELA_Human5.30921540
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.90800563
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.60325312
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.34989666
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.17599253
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.91802833
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81054790
9SCL_19346495_ChIP-Seq_HPC-7_Human3.78163995
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64245252
11EZH2_22144423_ChIP-Seq_EOC_Human3.47496871
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.26601942
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.11520210
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08944493
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00398674
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.99807917
17GBX2_23144817_ChIP-Seq_PC3_Human2.98370518
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92053179
19ZNF274_21170338_ChIP-Seq_K562_Hela2.90092509
20GATA1_22025678_ChIP-Seq_K562_Human2.77749656
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74298483
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61955849
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60267992
24* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58199061
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54853085
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52278913
27RUNX_20019798_ChIP-Seq_JUKART_Human2.49735117
28IGF1R_20145208_ChIP-Seq_DFB_Human2.45173105
29MYB_26560356_Chip-Seq_TH2_Human2.41709342
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.36712645
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34472371
32EWS_26573619_Chip-Seq_HEK293_Human2.29078018
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26645695
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.24782238
35MYB_26560356_Chip-Seq_TH1_Human2.19403619
36SPI1_23547873_ChIP-Seq_NB4_Human2.13599703
37TAF15_26573619_Chip-Seq_HEK293_Human2.10670357
38* FUS_26573619_Chip-Seq_HEK293_Human2.07908915
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05953499
40VDR_22108803_ChIP-Seq_LS180_Human2.05937359
41ER_23166858_ChIP-Seq_MCF-7_Human2.04333111
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99415948
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98734838
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94919648
45MAF_26560356_Chip-Seq_TH1_Human1.92997152
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.92690947
47P300_19829295_ChIP-Seq_ESCs_Human1.84655262
48IRF1_19129219_ChIP-ChIP_H3396_Human1.80042869
49* RUNX1_22412390_ChIP-Seq_EML_Mouse1.79867383
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79393910
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.78732435
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.78402369
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73993051
54VDR_21846776_ChIP-Seq_THP-1_Human1.72108083
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71565326
56MYC_22102868_ChIP-Seq_BL_Human1.71016096
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69767996
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69310605
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69310605
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68096834
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67180900
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66047780
63VDR_24763502_ChIP-Seq_THP-1_Human1.65212212
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64746020
65* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64710141
66* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61658680
67* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59314831
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58685773
69PU_27001747_Chip-Seq_BMDM_Mouse1.58102322
70* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56761614
71UTX_26944678_Chip-Seq_JUKART_Human1.53862984
72TCF7_22412390_ChIP-Seq_EML_Mouse1.51737426
73STAT3_23295773_ChIP-Seq_U87_Human1.47809745
74BCAT_22108803_ChIP-Seq_LS180_Human1.47099292
75TP53_22573176_ChIP-Seq_HFKS_Human1.46892307
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46604086
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44446461
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44049804
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43380322
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43244164
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41646167
82* TCF4_23295773_ChIP-Seq_U87_Human1.41254581
83GATA3_27048872_Chip-Seq_THYMUS_Human1.40733150
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40395445
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40162230
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39793140
87* SMAD4_21799915_ChIP-Seq_A2780_Human1.39606382
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38493872
89CBP_20019798_ChIP-Seq_JUKART_Human1.38493872
90* SPI1_23127762_ChIP-Seq_K562_Human1.36825240
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36571983
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36174606
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.35682911
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34831224
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34361635
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.33452142
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32926002
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.32059504
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.29526714
100MYC_18940864_ChIP-ChIP_HL60_Human1.27414078
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25359474
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24521478
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24021308
104AR_25329375_ChIP-Seq_VCAP_Human1.23714640
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23457543
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23452819
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.22438286
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22420306
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21352390
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.19789398
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19687397
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19457251
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19196534
114RNF2_27304074_Chip-Seq_NSC_Mouse1.18897515
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18251157
116* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17245001
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16193043
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.14884581
119REST_21632747_ChIP-Seq_MESCs_Mouse1.13472697
120TCF4_22108803_ChIP-Seq_LS180_Human1.13030024
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12971014
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12762482
123RUNX2_22187159_ChIP-Seq_PCA_Human1.11716312
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10148358
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09620133
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09319355
127AR_21572438_ChIP-Seq_LNCaP_Human1.09141059
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09048625
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.08989663
130* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07971526
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07820197
132* PIAS1_25552417_ChIP-Seq_VCAP_Human1.07788456
133VDR_24787735_ChIP-Seq_THP-1_Human1.06941149
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05620848
135FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05343043
136* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04506851
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02781220
138SOX2_19829295_ChIP-Seq_ESCs_Human1.02757390
139NANOG_19829295_ChIP-Seq_ESCs_Human1.02757390
140NCOR_22424771_ChIP-Seq_293T_Human1.02552243
141FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01532429
142FOXA1_25329375_ChIP-Seq_VCAP_Human1.01532429
143* SMRT_27268052_Chip-Seq_Bcells_Human1.00840563
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00342736
145GATA3_26560356_Chip-Seq_TH2_Human1.00156752
146TAL1_26923725_Chip-Seq_HPCs_Mouse1.00007693
147MAF_26560356_Chip-Seq_TH2_Human0.99955774
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99848321
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99265566
150* CIITA_25753668_ChIP-Seq_RAJI_Human0.95934163
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.95668620
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95521025
153GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95340326
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.93091837
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92926978
156ELK1_19687146_ChIP-ChIP_HELA_Human0.91057349
157ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90825670
158PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90819856
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90180220
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88056740
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86531764
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.80738768
163* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79478966
164VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77731290
165PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76632918
166* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76320551
167VDR_23849224_ChIP-Seq_CD4+_Human0.76176972
168BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76010448
169FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75870736
170NCOR1_26117541_ChIP-Seq_K562_Human0.73821497
171GATA2_19941826_ChIP-Seq_K562_Human0.71537753
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70608985
173FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69898626
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69685764
175CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69385308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.15956643
2MP0005671_abnormal_response_to3.48175769
3MP0009785_altered_susceptibility_to3.01057321
4MP0001800_abnormal_humoral_immune2.86550056
5MP0005000_abnormal_immune_tolerance2.81022354
6MP0000685_abnormal_immune_system2.71947752
7MP0002148_abnormal_hypersensitivity_rea2.68930790
8MP0002452_abnormal_antigen_presenting2.65059098
9MP0005387_immune_system_phenotype2.63475666
10MP0001790_abnormal_immune_system2.63475666
11MP0003436_decreased_susceptibility_to2.58034037
12MP0002723_abnormal_immune_serum2.56627306
13MP0003763_abnormal_thymus_physiology2.52561531
14MP0005025_abnormal_response_to2.47645009
15MP0002420_abnormal_adaptive_immunity2.46617124
16MP0001819_abnormal_immune_cell2.46400340
17MP0003724_increased_susceptibility_to2.45255122
18MP0004808_abnormal_hematopoietic_stem2.43770336
19MP0002396_abnormal_hematopoietic_system2.38543064
20MP0002419_abnormal_innate_immunity2.34577465
21MP0002398_abnormal_bone_marrow2.34251630
22MP0002166_altered_tumor_susceptibility2.22899266
23MP0002006_tumorigenesis2.19463235
24MP0005174_abnormal_tail_pigmentation2.15837030
25MP0000716_abnormal_immune_system2.08856643
26MP0006082_CNS_inflammation2.07277712
27MP0008057_abnormal_DNA_replication2.02098002
28MP0005464_abnormal_platelet_physiology2.01062751
29MP0010155_abnormal_intestine_physiology1.96959559
30MP0003121_genomic_imprinting1.96518736
31MP0002102_abnormal_ear_morphology1.95808331
32MP0004510_myositis1.95419130
33MP0002638_abnormal_pupillary_reflex1.94855811
34MP0005397_hematopoietic_system_phenotyp1.90554801
35MP0001545_abnormal_hematopoietic_system1.90554801
36MP0003303_peritoneal_inflammation1.87930851
37MP0000569_abnormal_digit_pigmentation1.86552406
38MP0003195_calcinosis1.86123059
39MP0001853_heart_inflammation1.84251298
40MP0002405_respiratory_system_inflammati1.82934367
41MP0002722_abnormal_immune_system1.80085949
42MP0005646_abnormal_pituitary_gland1.76504871
43MP0000689_abnormal_spleen_morphology1.76195146
44MP0006072_abnormal_retinal_apoptosis1.75389402
45MP0002429_abnormal_blood_cell1.74667131
46MP0005310_abnormal_salivary_gland1.69793793
47MP0005551_abnormal_eye_electrophysiolog1.67883618
48MP0000703_abnormal_thymus_morphology1.67881874
49MP0003646_muscle_fatigue1.67221620
50MP0000015_abnormal_ear_pigmentation1.65578013
51MP0005645_abnormal_hypothalamus_physiol1.62207235
52MP0001873_stomach_inflammation1.60665007
53MP0000631_abnormal_neuroendocrine_gland1.59882704
54MP0001845_abnormal_inflammatory_respons1.55037856
55MP0004142_abnormal_muscle_tone1.53476190
56MP0005075_abnormal_melanosome_morpholog1.53061193
57MP0005253_abnormal_eye_physiology1.53037556
58MP0002163_abnormal_gland_morphology1.52612848
59MP0003828_pulmonary_edema1.50642180
60MP0009278_abnormal_bone_marrow1.50195545
61MP0006292_abnormal_olfactory_placode1.49995675
62MP0000490_abnormal_crypts_of1.48157908
63MP0002009_preneoplasia1.47592591
64MP0001968_abnormal_touch/_nociception1.47130322
65MP0003011_delayed_dark_adaptation1.46482092
66MP0003300_gastrointestinal_ulcer1.46269880
67MP0003866_abnormal_defecation1.43477963
68MP0004133_heterotaxia1.40697478
69MP0008872_abnormal_physiological_respon1.39477915
70MP0009764_decreased_sensitivity_to1.39424016
71MP0004947_skin_inflammation1.38901702
72MP0002735_abnormal_chemical_nociception1.38332937
73MP0009745_abnormal_behavioral_response1.37337729
74MP0005389_reproductive_system_phenotype1.34896960
75MP0000465_gastrointestinal_hemorrhage1.34578492
76MP0002138_abnormal_hepatobiliary_system1.33643578
77MP0002095_abnormal_skin_pigmentation1.32116835
78MP0003880_abnormal_central_pattern1.32099936
79MP0002160_abnormal_reproductive_system1.30974156
80MP0003172_abnormal_lysosome_physiology1.30065752
81MP0008058_abnormal_DNA_repair1.26282390
82MP0001919_abnormal_reproductive_system1.26014307
83MP0009046_muscle_twitch1.23848432
84MP0004885_abnormal_endolymph1.23737425
85MP0002876_abnormal_thyroid_physiology1.23406541
86MP0002272_abnormal_nervous_system1.22986249
87MP0009333_abnormal_splenocyte_physiolog1.19941088
88MP0010094_abnormal_chromosome_stability1.18709487
89MP0005379_endocrine/exocrine_gland_phen1.17543469
90MP0001533_abnormal_skeleton_physiology1.16582819
91MP0003890_abnormal_embryonic-extraembry1.15623902
92MP0003183_abnormal_peptide_metabolism1.15401026
93MP0000427_abnormal_hair_cycle1.14330834
94MP0001486_abnormal_startle_reflex1.13849882
95MP0002837_dystrophic_cardiac_calcinosis1.13595158
96MP0006276_abnormal_autonomic_nervous1.11523325
97MP0002736_abnormal_nociception_after1.10949492
98MP0005084_abnormal_gallbladder_morpholo1.10912943
99MP0000371_diluted_coat_color1.09591954
100MP0002277_abnormal_respiratory_mucosa1.09089348
101MP0010307_abnormal_tumor_latency1.07081837
102MP0001986_abnormal_taste_sensitivity1.06734571
103MP0004043_abnormal_pH_regulation1.06731490
104MP0004145_abnormal_muscle_electrophysio1.06313634
105MP0008469_abnormal_protein_level1.06116723
106MP0003252_abnormal_bile_duct1.05010068
107MP0001485_abnormal_pinna_reflex1.04177996
108MP0004742_abnormal_vestibular_system1.02781478
109MP0003448_altered_tumor_morphology1.00668848
110MP0003693_abnormal_embryo_hatching0.98821440
111MP0010386_abnormal_urinary_bladder0.97061447
112MP0000858_altered_metastatic_potential0.96761337
113MP0004381_abnormal_hair_follicle0.96508599
114MP0000383_abnormal_hair_follicle0.94544133
115MP0003943_abnormal_hepatobiliary_system0.94273387
116MP0008007_abnormal_cellular_replicative0.90632552
117MP0003077_abnormal_cell_cycle0.89071382
118MP0003122_maternal_imprinting0.89017922
119MP0002075_abnormal_coat/hair_pigmentati0.87918399
120MP0002933_joint_inflammation0.87771297
121MP0002019_abnormal_tumor_incidence0.87263587
122MP0001929_abnormal_gametogenesis0.85530862
123MP0005195_abnormal_posterior_eye0.85006579
124MP0005058_abnormal_lysosome_morphology0.84051205
125MP0003787_abnormal_imprinting0.83763098
126MP0001970_abnormal_pain_threshold0.83693835
127MP0003698_abnormal_male_reproductive0.81711291
128MP0008995_early_reproductive_senescence0.81107559
129MP0005386_behavior/neurological_phenoty0.80420569
130MP0004924_abnormal_behavior0.80420569
131MP0003635_abnormal_synaptic_transmissio0.80367934
132MP0002653_abnormal_ependyma_morphology0.79632055
133MP0002557_abnormal_social/conspecific_i0.79489938
134MP0005220_abnormal_exocrine_pancreas0.79199403
135MP0002064_seizures0.78698124
136MP0002733_abnormal_thermal_nociception0.78605534
137MP0003111_abnormal_nucleus_morphology0.77250839
138MP0000653_abnormal_sex_gland0.76758451
139MP0002063_abnormal_learning/memory/cond0.76678598
140MP0002210_abnormal_sex_determination0.76104188
141MP0002572_abnormal_emotion/affect_behav0.75606441
142MP0000778_abnormal_nervous_system0.75220157
143MP0002998_abnormal_bone_remodeling0.74672644
144MP0003136_yellow_coat_color0.73520320
145MP0001145_abnormal_male_reproductive0.73057515
146MP0001440_abnormal_grooming_behavior0.72734450
147MP0000343_altered_response_to0.71314523
148MP0001851_eye_inflammation0.70829015
149MP0001186_pigmentation_phenotype0.66733252
150MP0005076_abnormal_cell_differentiation0.66575903
151MP0010352_gastrointestinal_tract_polyps0.64784909
152MP0009763_increased_sensitivity_to0.64765325
153MP0002132_abnormal_respiratory_system0.64406526
154MP0002877_abnormal_melanocyte_morpholog0.64140427
155MP0000313_abnormal_cell_death0.63378507
156MP0002928_abnormal_bile_duct0.63047959
157MP0004147_increased_porphyrin_level0.62789856
158MP0005409_darkened_coat_color0.61425114
159MP0001879_abnormal_lymphatic_vessel0.58800932
160MP0008877_abnormal_DNA_methylation0.58733733
161MP0004782_abnormal_surfactant_physiolog0.56859373
162MP0003045_fibrosis0.56829909
163MP0000372_irregular_coat_pigmentation0.56228012
164MP0000767_abnormal_smooth_muscle0.56192135

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.68287437
2Eczematoid dermatitis (HP:0000976)4.06053535
3Pancreatic cysts (HP:0001737)4.04419482
4Recurrent bacterial skin infections (HP:0005406)4.03134552
5Myositis (HP:0100614)3.91650512
6Recurrent viral infections (HP:0004429)3.87707482
7Recurrent fungal infections (HP:0002841)3.78185927
8Mediastinal lymphadenopathy (HP:0100721)3.74718342
9Pancreatic fibrosis (HP:0100732)3.70646584
10Abnormality of the fingertips (HP:0001211)3.64296550
11Retrobulbar optic neuritis (HP:0100654)3.56117523
12Optic neuritis (HP:0100653)3.56117523
13Abnormality of midbrain morphology (HP:0002418)3.50028528
14Molar tooth sign on MRI (HP:0002419)3.50028528
15True hermaphroditism (HP:0010459)3.46951866
16Meningitis (HP:0001287)3.43626998
17Spontaneous hematomas (HP:0007420)3.42675691
18IgM deficiency (HP:0002850)3.41210585
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.36029385
20Elevated erythrocyte sedimentation rate (HP:0003565)3.29632961
21Nephronophthisis (HP:0000090)3.25423757
22Chronic mucocutaneous candidiasis (HP:0002728)3.24392812
23Recurrent cutaneous fungal infections (HP:0011370)3.24392812
24Thyroiditis (HP:0100646)3.23792822
25Vasculitis (HP:0002633)3.19878969
26Prolonged bleeding time (HP:0003010)3.19651571
27Petechiae (HP:0000967)3.17480495
28Orchitis (HP:0100796)3.15585633
29Agammaglobulinemia (HP:0004432)3.14411814
30Abnormality of T cell number (HP:0011839)3.12723824
31T lymphocytopenia (HP:0005403)3.12504124
32Panhypogammaglobulinemia (HP:0003139)3.11273828
33Recurrent skin infections (HP:0001581)3.03055009
34Chromsome breakage (HP:0040012)3.01550200
35Chronic obstructive pulmonary disease (HP:0006510)3.00728851
36Obstructive lung disease (HP:0006536)3.00728851
37Stomatitis (HP:0010280)2.98294866
38Abnormality of the renal cortex (HP:0011035)2.97688041
39Cellulitis (HP:0100658)2.92175978
40Autoimmune thrombocytopenia (HP:0001973)2.91208345
41Chronic otitis media (HP:0000389)2.90330597
42Abnormality of the renal medulla (HP:0100957)2.89329770
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89040735
44Abnormality of T cells (HP:0002843)2.88569960
45Hematochezia (HP:0002573)2.83096291
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80818822
47Pustule (HP:0200039)2.76671209
48Prostate neoplasm (HP:0100787)2.72939839
49Congenital stationary night blindness (HP:0007642)2.69776267
50Gastrointestinal stroma tumor (HP:0100723)2.68682032
51Recurrent bronchitis (HP:0002837)2.68105097
52Thrombocytosis (HP:0001894)2.67452992
53Recurrent gram-negative bacterial infections (HP:0005420)2.64674961
54Lymphopenia (HP:0001888)2.62218314
55Periodontitis (HP:0000704)2.61286039
56Pulmonary infiltrates (HP:0002113)2.60452366
57Abnormality of macrophages (HP:0004311)2.59530962
58Encephalitis (HP:0002383)2.58432388
59Abnormal rod and cone electroretinograms (HP:0008323)2.58186994
60Stomach cancer (HP:0012126)2.57177508
61Abnormality of T cell physiology (HP:0011840)2.56848430
62Abnormality of the prostate (HP:0008775)2.56323226
63Inflammation of the large intestine (HP:0002037)2.55925821
64Arterial thrombosis (HP:0004420)2.55115808
65Epistaxis (HP:0000421)2.55035462
66Leukocytosis (HP:0001974)2.54006959
67Abnormality of B cell number (HP:0010975)2.51885473
68B lymphocytopenia (HP:0010976)2.51885473
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.50693775
70Renal cortical cysts (HP:0000803)2.50443688
71Hyperventilation (HP:0002883)2.49375665
72Abnormality of eosinophils (HP:0001879)2.47769840
73IgG deficiency (HP:0004315)2.44731470
74Chronic hepatic failure (HP:0100626)2.43816908
75Severe combined immunodeficiency (HP:0004430)2.43475595
76Amaurosis fugax (HP:0100576)2.42958973
77Gingival bleeding (HP:0000225)2.42172262
78Acute myeloid leukemia (HP:0004808)2.41378579
79Lymphoma (HP:0002665)2.39668035
80Chronic diarrhea (HP:0002028)2.39111290
81Eosinophilia (HP:0001880)2.38584311
82Gastrointestinal inflammation (HP:0004386)2.38488376
83Hemoptysis (HP:0002105)2.37260058
84Medial flaring of the eyebrow (HP:0010747)2.32352232
85Abolished electroretinogram (ERG) (HP:0000550)2.30375545
86Recurrent pneumonia (HP:0006532)2.30320365
87Cystic liver disease (HP:0006706)2.28973905
88Keratoconjunctivitis sicca (HP:0001097)2.28700766
89Clubbing of toes (HP:0100760)2.27083233
90Granulocytopenia (HP:0001913)2.23761603
91Gingivitis (HP:0000230)2.23533552
92Recurrent sinusitis (HP:0011108)2.22172718
93Pendular nystagmus (HP:0012043)2.18735961
94Myelodysplasia (HP:0002863)2.18093639
95Keratoconjunctivitis (HP:0001096)2.18061428
96Attenuation of retinal blood vessels (HP:0007843)2.16922576
97Volvulus (HP:0002580)2.16917126
98Neoplasm of the adrenal cortex (HP:0100641)2.14401069
99Chest pain (HP:0100749)2.14209110
100Bony spicule pigmentary retinopathy (HP:0007737)2.13706907
101Progressive cerebellar ataxia (HP:0002073)2.12541660
102Osteomyelitis (HP:0002754)2.12499519
103Colon cancer (HP:0003003)2.12416282
104Combined immunodeficiency (HP:0005387)2.09314975
105Leukopenia (HP:0001882)2.08955575
106Broad-based gait (HP:0002136)2.08451309
107Recurrent lower respiratory tract infections (HP:0002783)2.08080230
108Anencephaly (HP:0002323)2.07495265
109Furrowed tongue (HP:0000221)2.07246189
110IgA deficiency (HP:0002720)2.06801469
111Basal ganglia calcification (HP:0002135)2.06457006
112Colitis (HP:0002583)2.05423039
113Genetic anticipation (HP:0003743)2.05063180
114Gaze-evoked nystagmus (HP:0000640)2.04772225
115Asplenia (HP:0001746)2.03439522
116Aplasia/Hypoplasia of the spleen (HP:0010451)2.03367014
117Decreased central vision (HP:0007663)2.02638089
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.02388383
119Absent/shortened dynein arms (HP:0200106)2.02388383
120Type II lissencephaly (HP:0007260)2.02057399
121Polydipsia (HP:0001959)1.94580169
122Abnormal drinking behavior (HP:0030082)1.94580169
123Depressed nasal tip (HP:0000437)1.92671997
124Sclerocornea (HP:0000647)1.92073427
125Microcytic anemia (HP:0001935)1.91342927
126Male pseudohermaphroditism (HP:0000037)1.90768196
127Abnormality of the columella (HP:0009929)1.89258901
128Abnormality of DNA repair (HP:0003254)1.88296546
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.88014832
130Interstitial pulmonary disease (HP:0006530)1.87727404
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.87606562
132Absent thumb (HP:0009777)1.87603890
133Abnormality of chromosome stability (HP:0003220)1.87379179
134Tubular atrophy (HP:0000092)1.85989788
135Thyroid-stimulating hormone excess (HP:0002925)1.85317162
136Increased IgM level (HP:0003496)1.84821618
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.84564519
138Congenital hepatic fibrosis (HP:0002612)1.83602628
139Sepsis (HP:0100806)1.83148791
140Chronic sinusitis (HP:0011109)1.82868135
141Abnormal platelet function (HP:0011869)1.82848094
142Impaired platelet aggregation (HP:0003540)1.82848094
143Postaxial foot polydactyly (HP:0001830)1.81888064
144Acute lymphatic leukemia (HP:0006721)1.80453593
145Lip pit (HP:0100267)1.80214460
146Hypochromic microcytic anemia (HP:0004840)1.80029702
147Protruding tongue (HP:0010808)1.79247637
148Aplastic anemia (HP:0001915)1.78462054
149Hip dysplasia (HP:0001385)1.78399845
150Gait imbalance (HP:0002141)1.77300313
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.75034744
152Optic nerve hypoplasia (HP:0000609)1.74636213
153Neoplasm of the tracheobronchial system (HP:0100552)1.74065551
154Constricted visual fields (HP:0001133)1.73535885
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72739558
156Hypothermia (HP:0002045)1.67833061
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64704030
158Febrile seizures (HP:0002373)1.64654359
159Abnormal respiratory motile cilium morphology (HP:0005938)1.63931943
160Abnormal respiratory epithelium morphology (HP:0012253)1.63931943
161Tubulointerstitial nephritis (HP:0001970)1.61955500
162Progressive macrocephaly (HP:0004481)1.60893032
163Lissencephaly (HP:0001339)1.60625357
164Meckel diverticulum (HP:0002245)1.60030645
165Oligodactyly (hands) (HP:0001180)1.59204405
166Abnormality of the labia minora (HP:0012880)1.59068760
167Abnormality of the ileum (HP:0001549)1.58951330
168Congenital primary aphakia (HP:0007707)1.58779749
169Genital tract atresia (HP:0001827)1.58499454
170Aqueductal stenosis (HP:0002410)1.58194435
1713-Methylglutaconic aciduria (HP:0003535)1.57161149
172Hypoplasia of the fovea (HP:0007750)1.55449536
173Aplasia/Hypoplasia of the fovea (HP:0008060)1.55449536
174Abnormal ciliary motility (HP:0012262)1.55431418
175Hypoplasia of the pons (HP:0012110)1.55260360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14567836
2TXK3.85760070
3MAP4K13.69985894
4TLK13.07714166
5MAP3K142.89755689
6MAP4K22.89240434
7IRAK42.88327468
8RIPK42.78753373
9IRAK32.65030977
10WNK32.60163489
11IKBKE2.51199621
12JAK32.45736839
13BLK2.23256982
14BMPR1B2.21534291
15KIT2.15863392
16TEC2.09804122
17TAOK32.04486987
18ACVR1B2.04079673
19BTK1.95316262
20TYK21.88003868
21IKBKB1.85729201
22CDK121.83468938
23PINK11.83355385
24TBK11.75824131
25FGFR31.68453530
26INSRR1.67797654
27TGFBR21.67669616
28MAPK131.67035336
29CASK1.65142114
30TIE11.62815807
31JAK11.61599037
32YES11.59492508
33MAP3K131.59365613
34MKNK21.57437099
35CHUK1.56820292
36ZAP701.56698666
37SYK1.55375152
38ITK1.52493194
39WNK41.52135189
40MAP3K41.49337851
41NLK1.46327992
42PIM11.45505663
43SIK21.38016287
44BRD41.37819667
45MAP2K61.33675827
46STK241.32768505
47STK41.32715236
48STK391.26354865
49LCK1.23355793
50TRPM71.22466894
51OXSR11.21378261
52TNIK1.21212843
53LYN1.16082649
54HCK1.13264508
55MKNK11.09414934
56PLK41.08727866
57FGFR41.06721369
58MAP2K31.05326026
59CDC71.01844349
60CAMKK21.00552335
61EIF2AK20.99545015
62CSF1R0.98935912
63DYRK20.98537987
64FLT30.97458977
65CCNB10.97397623
66ADRBK20.96928250
67STK100.92076966
68PLK20.91548803
69CSK0.90628628
70STK110.86359712
71RPS6KA40.83653696
72ZAK0.81631631
73HIPK20.79940578
74JAK20.79277016
75MATK0.76969445
76PIK3CA0.76222543
77MAP3K100.75475043
78MAP2K70.75466717
79BMPR20.75316649
80PNCK0.75014478
81CLK10.74860441
82TAF10.73549358
83PAK30.73383927
84STK30.71879137
85ATR0.69805283
86IRAK10.68973228
87SGK20.68087696
88SRPK10.67659032
89MUSK0.67556788
90TNK20.67359728
91CDK90.67346247
92FES0.66450798
93CDK30.65059480
94MST40.64362526
95CAMK1D0.62838909
96MARK10.62545007
97NUAK10.62510609
98SGK30.62457706
99SGK10.62279806
100WNK10.61569512
101VRK10.61438565
102MAP3K60.61167114
103TRIM280.58652513
104ADRBK10.58627019
105CDK60.58094547
106MARK30.57656742
107EEF2K0.57127241
108PRKCZ0.55604937
109MAP2K40.53120387
110STK160.51949329
111CDK40.51786360
112MAP2K20.51614081
113GRK60.51613538
114TGFBR10.51201219
115NME20.50499097
116RPS6KA50.49556571
117NTRK20.47635419
118FGFR20.47527240
119PDGFRB0.47116236
120BRSK20.46773893
121MAPK150.46217439
122DYRK1A0.45816298
123SGK2230.45432386
124SGK4940.45432386
125NTRK30.45226164
126ATM0.44511060
127CAMK10.44113160
128MELK0.43260409
129PRKCG0.42239003
130NME10.41738014
131CDK190.41603224
132MINK10.41237638
133GRK50.40380156
134RPS6KA60.40028548
135PRKD20.39816697
136CAMK1G0.39566102
137ABL10.38909597
138PRKCQ0.38801448
139MAP3K70.37213684
140CDK70.36949581
141EPHA40.36717956
142DYRK30.36710911
143NEK20.35494243
144GRK10.34679761
145PIK3CG0.34627769
146AURKB0.34323947
147EPHA30.32733858
148PDK10.32219645
149PIM20.31531654
150GRK70.30952792

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.75125162
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.70964383
3Leishmaniasis_Homo sapiens_hsa051402.57628532
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.51573809
5Graft-versus-host disease_Homo sapiens_hsa053322.38563515
6Measles_Homo sapiens_hsa051622.34859699
7Allograft rejection_Homo sapiens_hsa053302.33474225
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32043154
9Phototransduction_Homo sapiens_hsa047442.25723091
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22719521
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.20291385
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16929521
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08685559
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05731711
15Hematopoietic cell lineage_Homo sapiens_hsa046402.03065984
16Osteoclast differentiation_Homo sapiens_hsa043802.00660195
17B cell receptor signaling pathway_Homo sapiens_hsa046621.98685697
18Herpes simplex infection_Homo sapiens_hsa051681.97382606
19Linoleic acid metabolism_Homo sapiens_hsa005911.84112485
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83710371
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83535726
22Nicotine addiction_Homo sapiens_hsa050331.80633524
23Dorso-ventral axis formation_Homo sapiens_hsa043201.71308395
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.68592730
25RNA polymerase_Homo sapiens_hsa030201.68148793
26Influenza A_Homo sapiens_hsa051641.66521992
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66233137
28Autoimmune thyroid disease_Homo sapiens_hsa053201.59097121
29T cell receptor signaling pathway_Homo sapiens_hsa046601.57738927
30TNF signaling pathway_Homo sapiens_hsa046681.55955842
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55352367
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49265130
33Ether lipid metabolism_Homo sapiens_hsa005651.42789948
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.42649772
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42185667
36Type I diabetes mellitus_Homo sapiens_hsa049401.37972710
37Legionellosis_Homo sapiens_hsa051341.35535425
38Olfactory transduction_Homo sapiens_hsa047401.35481612
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35161132
40Hepatitis B_Homo sapiens_hsa051611.34227436
41Pertussis_Homo sapiens_hsa051331.34010032
42Tuberculosis_Homo sapiens_hsa051521.33648936
43Toxoplasmosis_Homo sapiens_hsa051451.32220147
44Antigen processing and presentation_Homo sapiens_hsa046121.31663400
45Asthma_Homo sapiens_hsa053101.30996293
46Malaria_Homo sapiens_hsa051441.29497032
47Oxidative phosphorylation_Homo sapiens_hsa001901.24948128
48Nitrogen metabolism_Homo sapiens_hsa009101.24651987
49Chemokine signaling pathway_Homo sapiens_hsa040621.21922790
50Fanconi anemia pathway_Homo sapiens_hsa034601.17858650
51Protein export_Homo sapiens_hsa030601.16957773
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16216337
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15907816
54Non-homologous end-joining_Homo sapiens_hsa034501.14610782
55Morphine addiction_Homo sapiens_hsa050321.14117467
56Apoptosis_Homo sapiens_hsa042101.13856787
57Parkinsons disease_Homo sapiens_hsa050121.07837531
58Acute myeloid leukemia_Homo sapiens_hsa052211.07161081
59African trypanosomiasis_Homo sapiens_hsa051431.05936080
60Homologous recombination_Homo sapiens_hsa034401.05746901
61Taste transduction_Homo sapiens_hsa047421.02548893
62Rheumatoid arthritis_Homo sapiens_hsa053231.02511737
63DNA replication_Homo sapiens_hsa030301.01776675
64Butanoate metabolism_Homo sapiens_hsa006500.99815897
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98977943
66Prolactin signaling pathway_Homo sapiens_hsa049170.98514420
67Salmonella infection_Homo sapiens_hsa051320.95195080
68Base excision repair_Homo sapiens_hsa034100.94631371
69Chronic myeloid leukemia_Homo sapiens_hsa052200.91143084
70Hepatitis C_Homo sapiens_hsa051600.90006014
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89289674
72Selenocompound metabolism_Homo sapiens_hsa004500.88711484
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88304115
74Regulation of autophagy_Homo sapiens_hsa041400.88188698
75Viral myocarditis_Homo sapiens_hsa054160.87810886
76Staphylococcus aureus infection_Homo sapiens_hsa051500.86713642
77Circadian entrainment_Homo sapiens_hsa047130.86296157
78Platelet activation_Homo sapiens_hsa046110.85930851
79Mismatch repair_Homo sapiens_hsa034300.84324840
80Glutamatergic synapse_Homo sapiens_hsa047240.83905314
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77934424
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77877844
83Small cell lung cancer_Homo sapiens_hsa052220.77134279
84Caffeine metabolism_Homo sapiens_hsa002320.76759827
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76483316
86Pancreatic cancer_Homo sapiens_hsa052120.75923117
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74808928
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.74703171
89p53 signaling pathway_Homo sapiens_hsa041150.74300723
90Epstein-Barr virus infection_Homo sapiens_hsa051690.73337089
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72808221
92HTLV-I infection_Homo sapiens_hsa051660.72515920
93Huntingtons disease_Homo sapiens_hsa050160.71732770
94FoxO signaling pathway_Homo sapiens_hsa040680.71295250
95Serotonergic synapse_Homo sapiens_hsa047260.71140840
96RNA degradation_Homo sapiens_hsa030180.70769305
97Shigellosis_Homo sapiens_hsa051310.69540303
98Peroxisome_Homo sapiens_hsa041460.69148542
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.68520217
100Notch signaling pathway_Homo sapiens_hsa043300.66478333
101Arachidonic acid metabolism_Homo sapiens_hsa005900.65252474
102MicroRNAs in cancer_Homo sapiens_hsa052060.64767263
103GABAergic synapse_Homo sapiens_hsa047270.64553677
104Propanoate metabolism_Homo sapiens_hsa006400.64502968
105Alzheimers disease_Homo sapiens_hsa050100.63968751
106Insulin secretion_Homo sapiens_hsa049110.63683059
107Salivary secretion_Homo sapiens_hsa049700.63551919
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.63217455
109Cholinergic synapse_Homo sapiens_hsa047250.62571331
110Viral carcinogenesis_Homo sapiens_hsa052030.62089860
111Non-small cell lung cancer_Homo sapiens_hsa052230.62079391
112Long-term depression_Homo sapiens_hsa047300.61501876
113Purine metabolism_Homo sapiens_hsa002300.61263685
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61070527
115One carbon pool by folate_Homo sapiens_hsa006700.60041258
116Retinol metabolism_Homo sapiens_hsa008300.59573767
117Oxytocin signaling pathway_Homo sapiens_hsa049210.58508179
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57052163
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57032459
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.57030631
121Spliceosome_Homo sapiens_hsa030400.55240160
122Systemic lupus erythematosus_Homo sapiens_hsa053220.55114156
123Chemical carcinogenesis_Homo sapiens_hsa052040.55065091
124Other glycan degradation_Homo sapiens_hsa005110.54785053
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54272935
126cAMP signaling pathway_Homo sapiens_hsa040240.54233968
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.54021197
128mRNA surveillance pathway_Homo sapiens_hsa030150.53918689
129Tryptophan metabolism_Homo sapiens_hsa003800.53027649
130Nucleotide excision repair_Homo sapiens_hsa034200.52302431
131Renin secretion_Homo sapiens_hsa049240.52290415
132Pyrimidine metabolism_Homo sapiens_hsa002400.52008285
133Calcium signaling pathway_Homo sapiens_hsa040200.51882247
134Cell cycle_Homo sapiens_hsa041100.51167034
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50304844
136Type II diabetes mellitus_Homo sapiens_hsa049300.49503970
137Prostate cancer_Homo sapiens_hsa052150.49340088
138Insulin resistance_Homo sapiens_hsa049310.47693556
139Lysine degradation_Homo sapiens_hsa003100.47041003
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46593778
141Basal transcription factors_Homo sapiens_hsa030220.46057494
142ABC transporters_Homo sapiens_hsa020100.44230006
143Alcoholism_Homo sapiens_hsa050340.44051340
144Ribosome_Homo sapiens_hsa030100.40317231
145MAPK signaling pathway_Homo sapiens_hsa040100.40273247
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37981272
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37772197
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37362683
149Colorectal cancer_Homo sapiens_hsa052100.36902579
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35152295
151HIF-1 signaling pathway_Homo sapiens_hsa040660.34008090
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32360258
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.32304075
154Choline metabolism in cancer_Homo sapiens_hsa052310.31591342
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31527391
156Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30662505
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29606403
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29310746
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28927865

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