RSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.39520528
2histone H3-K4 trimethylation (GO:0080182)4.05676186
3presynaptic membrane assembly (GO:0097105)3.88399805
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.79778485
5negative regulation of translation, ncRNA-mediated (GO:0040033)3.79778485
6regulation of translation, ncRNA-mediated (GO:0045974)3.79778485
7neuron cell-cell adhesion (GO:0007158)3.74408994
8presynaptic membrane organization (GO:0097090)3.41310110
9nucleobase catabolic process (GO:0046113)3.40129751
10behavioral response to nicotine (GO:0035095)3.36589216
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30323694
12neural tube formation (GO:0001841)3.27438556
13dendritic spine morphogenesis (GO:0060997)3.13541408
14neuron recognition (GO:0008038)3.13192260
15axonal fasciculation (GO:0007413)3.11452231
16intraciliary transport (GO:0042073)3.07812381
17transmission of nerve impulse (GO:0019226)3.05360466
18mitotic sister chromatid cohesion (GO:0007064)3.02707783
19lateral sprouting from an epithelium (GO:0060601)3.00330005
20retinal ganglion cell axon guidance (GO:0031290)2.96904664
21cerebral cortex radially oriented cell migration (GO:0021799)2.93080745
22spinal cord development (GO:0021510)2.89902800
23central nervous system projection neuron axonogenesis (GO:0021952)2.87916807
24cell proliferation in forebrain (GO:0021846)2.85410875
25cytoplasmic mRNA processing body assembly (GO:0033962)2.81788851
26behavioral response to ethanol (GO:0048149)2.80648671
27head development (GO:0060322)2.80138690
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79129072
29mechanosensory behavior (GO:0007638)2.78245510
30kidney morphogenesis (GO:0060993)2.77768353
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.77713883
32substrate-independent telencephalic tangential migration (GO:0021826)2.77713883
33axon ensheathment in central nervous system (GO:0032291)2.76245042
34central nervous system myelination (GO:0022010)2.76245042
35limb bud formation (GO:0060174)2.75234692
36ionotropic glutamate receptor signaling pathway (GO:0035235)2.73832854
37centriole replication (GO:0007099)2.72489414
38mRNA splice site selection (GO:0006376)2.71725486
39negative regulation of neurotransmitter secretion (GO:0046929)2.70747268
40regulation of RNA export from nucleus (GO:0046831)2.70569314
41epithelial cilium movement (GO:0003351)2.69345841
42negative regulation of neurotransmitter transport (GO:0051589)2.68730706
43otic vesicle formation (GO:0030916)2.68354370
44glutamate receptor signaling pathway (GO:0007215)2.66772676
45olfactory bulb development (GO:0021772)2.66517940
46microtubule anchoring (GO:0034453)2.65058677
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63805003
48hindbrain development (GO:0030902)2.62922057
49peptidyl-lysine trimethylation (GO:0018023)2.62425853
50neurotransmitter-gated ion channel clustering (GO:0072578)2.60676380
51establishment of mitochondrion localization (GO:0051654)2.59210984
52startle response (GO:0001964)2.58619883
53positive regulation of synapse assembly (GO:0051965)2.58344790
54appendage development (GO:0048736)2.58208721
55limb development (GO:0060173)2.58208721
56postsynaptic membrane organization (GO:0001941)2.58023845
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57569345
58resolution of meiotic recombination intermediates (GO:0000712)2.57329066
59regulation of DNA endoreduplication (GO:0032875)2.56679406
60retina layer formation (GO:0010842)2.56349217
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55596867
62vocalization behavior (GO:0071625)2.55509103
63positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55314032
64regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55314032
65regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54781251
66sympathetic nervous system development (GO:0048485)2.51545757
67auditory behavior (GO:0031223)2.51221754
68protein localization to synapse (GO:0035418)2.49178056
69kinetochore organization (GO:0051383)2.48288806
70regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46905574
71histone H2B ubiquitination (GO:0033523)2.46370473
72establishment of protein localization to Golgi (GO:0072600)2.45714067
73positive regulation of mRNA processing (GO:0050685)2.45671215
74asymmetric protein localization (GO:0008105)2.45374914
75somite development (GO:0061053)2.44524531
76cell migration in hindbrain (GO:0021535)2.43683292
77histone H3-K4 methylation (GO:0051568)2.43092079
78regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.42743393
79positive regulation of dendritic spine morphogenesis (GO:0061003)2.42551872
80apical protein localization (GO:0045176)2.40808218
81spinal cord association neuron differentiation (GO:0021527)2.40724430
82negative regulation of axon guidance (GO:1902668)2.40281289
83cell differentiation in spinal cord (GO:0021515)2.39687512
84spinal cord motor neuron differentiation (GO:0021522)2.39452273
85positive regulation of histone H3-K4 methylation (GO:0051571)2.37498701
86regulation of timing of cell differentiation (GO:0048505)2.36759676
87regulation of glutamate receptor signaling pathway (GO:1900449)2.36517731
88neuron migration (GO:0001764)2.36354045
89hippocampus development (GO:0021766)2.36125372
90regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.32962339
91positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.32962339
92dendrite morphogenesis (GO:0048813)2.31782004
93cerebellar Purkinje cell differentiation (GO:0021702)2.31666582
94cilium assembly (GO:0042384)2.31575325
95tachykinin receptor signaling pathway (GO:0007217)2.31544115
96cilium organization (GO:0044782)2.30911213
97regulation of mRNA 3-end processing (GO:0031440)2.30778374
98forebrain neuron differentiation (GO:0021879)2.30657048
99regulation of synapse assembly (GO:0051963)2.30585198
100behavioral fear response (GO:0001662)2.29682251
101behavioral defense response (GO:0002209)2.29682251
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29521257
103central nervous system neuron axonogenesis (GO:0021955)2.29055130
104short-term memory (GO:0007614)2.27923106
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.26163628
106kinetochore assembly (GO:0051382)2.25934329
107cerebral cortex cell migration (GO:0021795)2.25372750
108regulation of cilium movement (GO:0003352)2.25044928
109regulation of dendritic spine morphogenesis (GO:0061001)2.24445706
110adult walking behavior (GO:0007628)2.24118542
111regulation of axon guidance (GO:1902667)2.23819213
112neuronal stem cell maintenance (GO:0097150)2.23089421
113response to auditory stimulus (GO:0010996)2.22643799
114regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22521629
115dendrite development (GO:0016358)2.22133655
116mitochondrion transport along microtubule (GO:0047497)2.21832802
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.21832802
118microtubule depolymerization (GO:0007019)2.20843084
119cilium movement (GO:0003341)2.20546508
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20161871
121regulation of respiratory gaseous exchange (GO:0043576)2.20158516
122Sertoli cell development (GO:0060009)2.19948666
123establishment of nucleus localization (GO:0040023)2.19857007
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.18358847
125regulation of short-term neuronal synaptic plasticity (GO:0048172)2.16526638
126regulation of nucleobase-containing compound transport (GO:0032239)2.15528441
127positive regulation of mRNA 3-end processing (GO:0031442)2.14491107
128layer formation in cerebral cortex (GO:0021819)2.14338744
129negative regulation of JUN kinase activity (GO:0043508)2.13898105
130retrograde transport, vesicle recycling within Golgi (GO:0000301)2.12420987
131nuclear pore complex assembly (GO:0051292)2.12402990
132lymphoid progenitor cell differentiation (GO:0002320)2.12011948
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.11891823
134regulation of respiratory system process (GO:0044065)2.11744536
135protein targeting to Golgi (GO:0000042)2.11249149
136synaptic transmission, glutamatergic (GO:0035249)2.10741017
137synapse assembly (GO:0007416)2.10432674
138histone H3-K9 methylation (GO:0051567)2.10201871
139regulation of development, heterochronic (GO:0040034)2.10156095
140genetic imprinting (GO:0071514)2.09118399
141myelination (GO:0042552)2.08247897
142suckling behavior (GO:0001967)2.05948369
143atrial cardiac muscle cell action potential (GO:0086014)2.05682407
144cranial nerve morphogenesis (GO:0021602)2.05348056
145regulation of telomere maintenance (GO:0032204)2.05019944
146regulation of mRNA splicing, via spliceosome (GO:0048024)2.04334091
147myelination in peripheral nervous system (GO:0022011)2.03897624
148peripheral nervous system axon ensheathment (GO:0032292)2.03897624
149regulation of histone H3-K4 methylation (GO:0051569)2.03218194
150regulation of axon extension involved in axon guidance (GO:0048841)2.02604005
151regulation of mRNA processing (GO:0050684)2.02441021
152nonmotile primary cilium assembly (GO:0035058)2.02185142
153ensheathment of neurons (GO:0007272)2.02125195
154axon ensheathment (GO:0008366)2.02125195
155stress granule assembly (GO:0034063)2.02001649
156regulation of pigment cell differentiation (GO:0050932)2.01080560
157neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.00998305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.75620922
2GBX2_23144817_ChIP-Seq_PC3_Human3.65600602
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97477327
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.80767078
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65024300
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60466431
7TAF15_26573619_Chip-Seq_HEK293_Human2.47393971
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44724989
9FUS_26573619_Chip-Seq_HEK293_Human2.38230479
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30752498
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24670481
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24197829
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07989452
14EWS_26573619_Chip-Seq_HEK293_Human1.98621623
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96862714
16P300_19829295_ChIP-Seq_ESCs_Human1.92462576
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92272961
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.90102435
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.89003809
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88404498
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84241390
22AR_21572438_ChIP-Seq_LNCaP_Human1.83275253
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82341954
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.82182658
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82172810
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81202133
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81078961
28IGF1R_20145208_ChIP-Seq_DFB_Human1.79396577
29SMAD4_21799915_ChIP-Seq_A2780_Human1.75085308
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74253525
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72057678
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71760954
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71563469
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71061204
35ER_23166858_ChIP-Seq_MCF-7_Human1.69010580
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.68927425
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65644584
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64917139
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61066197
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59965001
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.59900501
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59641941
43RNF2_27304074_Chip-Seq_NSC_Mouse1.57911352
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57372433
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56360672
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55541210
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.53362196
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52595203
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51078472
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50961648
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50961648
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.50725401
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50105203
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.50005075
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49150921
56TP53_16413492_ChIP-PET_HCT116_Human1.47750150
57STAT3_23295773_ChIP-Seq_U87_Human1.46952245
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43911091
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41306525
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.41302385
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41228635
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39317899
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38742566
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35514317
65TCF4_23295773_ChIP-Seq_U87_Human1.34560936
66CBP_20019798_ChIP-Seq_JUKART_Human1.32590040
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32590040
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.32115687
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31523247
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31523247
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31306845
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30879688
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29908220
74BCAT_22108803_ChIP-Seq_LS180_Human1.29568560
75* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28822063
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.28784237
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28663762
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.28468617
79ZNF274_21170338_ChIP-Seq_K562_Hela1.27339644
80DROSHA_22980978_ChIP-Seq_HELA_Human1.26727695
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22780371
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.21898934
83* REST_21632747_ChIP-Seq_MESCs_Mouse1.21830368
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.20927585
85SOX9_26525672_Chip-Seq_HEART_Mouse1.20115886
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20087832
87AHR_22903824_ChIP-Seq_MCF-7_Human1.19652347
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19501641
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19082267
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19039200
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18928852
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.17783500
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17026356
94* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16982020
95AR_25329375_ChIP-Seq_VCAP_Human1.16369965
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15926039
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15804762
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15245582
99TP53_18474530_ChIP-ChIP_U2OS_Human1.14309234
100* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14101812
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13916850
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13900509
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.13854753
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13644567
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10914559
106TCF4_22108803_ChIP-Seq_LS180_Human1.09841461
107P53_22387025_ChIP-Seq_ESCs_Mouse1.09374479
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09351883
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09328658
110VDR_22108803_ChIP-Seq_LS180_Human1.07234706
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06951793
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06441758
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06152193
114EZH2_27294783_Chip-Seq_NPCs_Mouse1.05606750
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05067715
116JUN_21703547_ChIP-Seq_K562_Human1.03948603
117* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03750192
118* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03100954
119* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02875611
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.02467124
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02282787
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01161375
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00993817
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.00129893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.99889168
2MP0005423_abnormal_somatic_nervous2.64134033
3MP0003787_abnormal_imprinting2.60854326
4MP0000569_abnormal_digit_pigmentation2.54400988
5MP0003122_maternal_imprinting2.46563114
6MP0005409_darkened_coat_color2.45702460
7MP0003121_genomic_imprinting2.30247920
8MP0000778_abnormal_nervous_system2.29339940
9MP0001188_hyperpigmentation2.23149644
10MP0008057_abnormal_DNA_replication2.14591973
11MP0006072_abnormal_retinal_apoptosis2.03752456
12MP0002938_white_spotting2.02691752
13MP0001486_abnormal_startle_reflex1.99964857
14MP0004270_analgesia1.93488934
15MP0003635_abnormal_synaptic_transmissio1.88775377
16MP0006276_abnormal_autonomic_nervous1.83957449
17MP0002736_abnormal_nociception_after1.82117664
18MP0005171_absent_coat_pigmentation1.79812876
19MP0004859_abnormal_synaptic_plasticity1.79535606
20MP0005645_abnormal_hypothalamus_physiol1.70264120
21MP0006292_abnormal_olfactory_placode1.67393611
22MP0005187_abnormal_penis_morphology1.62516762
23MP0001293_anophthalmia1.62493089
24MP0003136_yellow_coat_color1.59569298
25MP0009745_abnormal_behavioral_response1.57666489
26MP0000372_irregular_coat_pigmentation1.55326552
27MP0008877_abnormal_DNA_methylation1.54126588
28MP0000631_abnormal_neuroendocrine_gland1.52176887
29MP0002572_abnormal_emotion/affect_behav1.50578743
30MP0004885_abnormal_endolymph1.49385290
31MP0002063_abnormal_learning/memory/cond1.49152069
32MP0009046_muscle_twitch1.46109764
33MP0000566_synostosis1.43318953
34MP0009379_abnormal_foot_pigmentation1.42179811
35MP0002009_preneoplasia1.40245994
36MP0002184_abnormal_innervation1.36561226
37MP0002102_abnormal_ear_morphology1.36493220
38MP0003890_abnormal_embryonic-extraembry1.35492804
39MP0002272_abnormal_nervous_system1.35361590
40MP0002557_abnormal_social/conspecific_i1.35292672
41MP0005253_abnormal_eye_physiology1.35074187
42MP0002064_seizures1.33938593
43MP0002638_abnormal_pupillary_reflex1.32622672
44MP0005551_abnormal_eye_electrophysiolog1.31961204
45MP0005379_endocrine/exocrine_gland_phen1.30184937
46MP0002734_abnormal_mechanical_nocicepti1.29547674
47MP0002095_abnormal_skin_pigmentation1.28193756
48MP0003119_abnormal_digestive_system1.26899749
49MP0004742_abnormal_vestibular_system1.26888782
50MP0008789_abnormal_olfactory_epithelium1.25980318
51MP0003937_abnormal_limbs/digits/tail_de1.25437621
52MP0004145_abnormal_muscle_electrophysio1.25316675
53MP0003123_paternal_imprinting1.23623937
54MP0005646_abnormal_pituitary_gland1.23507064
55MP0001986_abnormal_taste_sensitivity1.21538529
56MP0001299_abnormal_eye_distance/1.19453869
57MP0001529_abnormal_vocalization1.18442850
58MP0000383_abnormal_hair_follicle1.17888661
59MP0002751_abnormal_autonomic_nervous1.17841335
60MP0003861_abnormal_nervous_system1.17748020
61MP0002234_abnormal_pharynx_morphology1.17147578
62MP0004134_abnormal_chest_morphology1.16697653
63MP0003938_abnormal_ear_development1.16527392
64MP0002882_abnormal_neuron_morphology1.16008823
65MP0000647_abnormal_sebaceous_gland1.15527374
66MP0002067_abnormal_sensory_capabilities1.14642184
67MP0001984_abnormal_olfaction1.13328983
68MP0001485_abnormal_pinna_reflex1.12043107
69MP0001440_abnormal_grooming_behavior1.11176206
70MP0005394_taste/olfaction_phenotype1.10718173
71MP0005499_abnormal_olfactory_system1.10718173
72MP0000015_abnormal_ear_pigmentation1.08861034
73MP0002152_abnormal_brain_morphology1.08065873
74MP0010678_abnormal_skin_adnexa1.07390684
75MP0002177_abnormal_outer_ear1.06939759
76MP0000955_abnormal_spinal_cord1.06359924
77MP0002653_abnormal_ependyma_morphology1.06183102
78MP0003755_abnormal_palate_morphology1.03960771
79MP0003567_abnormal_fetal_cardiomyocyte1.02274926
80MP0000427_abnormal_hair_cycle1.01677752
81MP0004133_heterotaxia1.01220610
82MP0003385_abnormal_body_wall1.01183246
83MP0001963_abnormal_hearing_physiology1.00472555
84MP0000049_abnormal_middle_ear0.99952002
85MP0000920_abnormal_myelination0.99615751
86MP0001968_abnormal_touch/_nociception0.99274100
87MP0002822_catalepsy0.99265096
88MP0002909_abnormal_adrenal_gland0.98716271
89MP0004811_abnormal_neuron_physiology0.98466040
90MP0009250_abnormal_appendicular_skeleto0.97357315
91MP0002752_abnormal_somatic_nervous0.97297455
92MP0005386_behavior/neurological_phenoty0.96985401
93MP0004924_abnormal_behavior0.96985401
94MP0008995_early_reproductive_senescence0.96870970
95MP0002735_abnormal_chemical_nociception0.96190006
96MP0000462_abnormal_digestive_system0.96146555
97MP0002163_abnormal_gland_morphology0.94842933
98MP0001970_abnormal_pain_threshold0.94012790
99MP0000026_abnormal_inner_ear0.93572860
100MP0000537_abnormal_urethra_morphology0.93500663
101MP0002233_abnormal_nose_morphology0.92884862
102MP0001346_abnormal_lacrimal_gland0.92823687
103MP0008058_abnormal_DNA_repair0.92733972
104MP0002697_abnormal_eye_size0.92348450
105MP0001324_abnormal_eye_pigmentation0.92060257
106MP0005248_abnormal_Harderian_gland0.91577982
107MP0005174_abnormal_tail_pigmentation0.91552762
108MP0001502_abnormal_circadian_rhythm0.89214973
109MP0001905_abnormal_dopamine_level0.88624425
110MP0003942_abnormal_urinary_system0.87224369
111MP0004142_abnormal_muscle_tone0.86870897
112MP0003878_abnormal_ear_physiology0.86151411
113MP0005377_hearing/vestibular/ear_phenot0.86151411
114MP0003935_abnormal_craniofacial_develop0.85003600
115MP0005367_renal/urinary_system_phenotyp0.83986655
116MP0000516_abnormal_urinary_system0.83986655
117MP0001177_atelectasis0.82938677
118MP0001501_abnormal_sleep_pattern0.82531192
119MP0002733_abnormal_thermal_nociception0.82331599
120MP0002116_abnormal_craniofacial_bone0.82099808
121MP0005391_vision/eye_phenotype0.81037870
122MP0001286_abnormal_eye_development0.81016270
123MP0005195_abnormal_posterior_eye0.77527894
124MP0002081_perinatal_lethality0.77395133

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.01157104
2Broad-based gait (HP:0002136)2.99217155
3Hepatoblastoma (HP:0002884)2.97129129
4Abnormality of the nasal septum (HP:0000419)2.93887461
5Hyperventilation (HP:0002883)2.84852506
6Colon cancer (HP:0003003)2.76731344
7Nephronophthisis (HP:0000090)2.72084961
8True hermaphroditism (HP:0010459)2.70224375
9Pancreatic cysts (HP:0001737)2.67096760
10Midline defect of the nose (HP:0004122)2.51751089
11Neoplasm of the adrenal cortex (HP:0100641)2.47179043
12Intestinal atresia (HP:0011100)2.41756463
13Widely spaced teeth (HP:0000687)2.41102452
14Abnormality of the renal medulla (HP:0100957)2.39550290
15Abnormality of the labia minora (HP:0012880)2.38023945
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34572509
17Short 4th metacarpal (HP:0010044)2.34572509
18Myokymia (HP:0002411)2.28080534
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26992926
20Abnormality of the renal collecting system (HP:0004742)2.25814498
21Excessive salivation (HP:0003781)2.22793275
22Drooling (HP:0002307)2.22793275
23Abnormal hair whorl (HP:0010721)2.20858816
24Gaze-evoked nystagmus (HP:0000640)2.16139650
25Congenital primary aphakia (HP:0007707)2.15124333
26Febrile seizures (HP:0002373)2.14599443
27Chromsome breakage (HP:0040012)2.12517418
28Cupped ear (HP:0000378)2.12384588
29Decreased lacrimation (HP:0000633)2.11856973
30Oligodactyly (HP:0012165)2.09091445
31Focal motor seizures (HP:0011153)2.07698802
32Duplicated collecting system (HP:0000081)2.06548631
33Alacrima (HP:0000522)2.06235923
34Progressive cerebellar ataxia (HP:0002073)2.05600973
35Megalencephaly (HP:0001355)2.04929771
36Genetic anticipation (HP:0003743)2.04874629
37Optic nerve hypoplasia (HP:0000609)2.04445393
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.02420835
39Rib fusion (HP:0000902)2.01988976
40Gastrointestinal atresia (HP:0002589)2.00790999
41Abnormal number of incisors (HP:0011064)2.00397992
42Abnormality of the parietal bone (HP:0002696)2.00349454
43Protruding tongue (HP:0010808)1.99759434
44Abnormality of the incisor (HP:0000676)1.96422898
45Abnormality of incisor morphology (HP:0011063)1.96262019
46Nephrogenic diabetes insipidus (HP:0009806)1.95458776
47Postaxial hand polydactyly (HP:0001162)1.94973078
48Esophageal atresia (HP:0002032)1.94764468
49Poor coordination (HP:0002370)1.94285550
50Exotropia (HP:0000577)1.93330150
51Supernumerary ribs (HP:0005815)1.92392745
52Abnormality of the ischium (HP:0003174)1.91520193
53Molar tooth sign on MRI (HP:0002419)1.89457988
54Abnormality of midbrain morphology (HP:0002418)1.89457988
55Abnormality of the fingertips (HP:0001211)1.88206778
56Papillary thyroid carcinoma (HP:0002895)1.88068424
57Limb dystonia (HP:0002451)1.88026284
58Postaxial foot polydactyly (HP:0001830)1.86158232
59Aqueductal stenosis (HP:0002410)1.85329853
60Increased number of teeth (HP:0011069)1.85274959
61Trigonocephaly (HP:0000243)1.85121248
62Gastroesophageal reflux (HP:0002020)1.84822879
63Specific learning disability (HP:0001328)1.83473938
64Supernumerary bones of the axial skeleton (HP:0009144)1.83387440
65Abnormality of the corticospinal tract (HP:0002492)1.82595590
66Anencephaly (HP:0002323)1.81572294
67Absent speech (HP:0001344)1.81152824
68Macroorchidism (HP:0000053)1.80729316
69Abnormality of the nasolacrimal system (HP:0000614)1.80394180
70Hypoplastic ischia (HP:0003175)1.80149840
71White forelock (HP:0002211)1.79967138
72Absent/shortened dynein arms (HP:0200106)1.79902473
73Dynein arm defect of respiratory motile cilia (HP:0012255)1.79902473
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79646952
75Degeneration of the lateral corticospinal tracts (HP:0002314)1.79646952
76Supernumerary spleens (HP:0009799)1.79359639
77Growth hormone deficiency (HP:0000824)1.79244572
78Cystic liver disease (HP:0006706)1.78975499
79Facial hemangioma (HP:0000329)1.78777162
80Glioma (HP:0009733)1.77199965
81Obsessive-compulsive behavior (HP:0000722)1.75792123
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75597865
83Focal seizures (HP:0007359)1.75358129
84Lip pit (HP:0100267)1.75322444
85Abnormality of the renal cortex (HP:0011035)1.74532240
86Anteriorly placed anus (HP:0001545)1.73375199
87Abnormality of salivation (HP:0100755)1.72591337
88Abnormal ciliary motility (HP:0012262)1.72452067
89Cutaneous finger syndactyly (HP:0010554)1.71363563
90Hypoplastic nipples (HP:0002557)1.71203153
91Neoplasm of the oral cavity (HP:0100649)1.70755962
92Chin dimple (HP:0010751)1.70585074
93Pachygyria (HP:0001302)1.69609183
94Blue irides (HP:0000635)1.69056693
95Abnormality of the astrocytes (HP:0100707)1.68765001
96Astrocytoma (HP:0009592)1.68765001
97Tubulointerstitial nephritis (HP:0001970)1.68534824
98Sensory axonal neuropathy (HP:0003390)1.68329871
99Sclerocornea (HP:0000647)1.67958504
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.67081349
101Atelectasis (HP:0100750)1.66967769
102Dandy-Walker malformation (HP:0001305)1.66733753
103Aplasia cutis congenita (HP:0001057)1.66150738
104Abnormality of the lacrimal duct (HP:0011481)1.65895332
105Cortical dysplasia (HP:0002539)1.65844129
106Bifid tongue (HP:0010297)1.65669241
107Astigmatism (HP:0000483)1.65561629
108Patellar aplasia (HP:0006443)1.65222014
109Small hand (HP:0200055)1.65037143
110Micropenis (HP:0000054)1.64849378
111Epileptic encephalopathy (HP:0200134)1.64812035
112Acute lymphatic leukemia (HP:0006721)1.64401023
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63189016
114Atonic seizures (HP:0010819)1.63061183
115Absent eyebrow (HP:0002223)1.62800200
116Shawl scrotum (HP:0000049)1.62704406
117Dialeptic seizures (HP:0011146)1.62497141
118Medulloblastoma (HP:0002885)1.62275028
119Labial hypoplasia (HP:0000066)1.61910580
120Congenital stationary night blindness (HP:0007642)1.61880926
121Ectopic kidney (HP:0000086)1.61156337
122Highly arched eyebrow (HP:0002553)1.60943455
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.60779916
124Cutaneous syndactyly (HP:0012725)1.60703630
125Anophthalmia (HP:0000528)1.60106907
126Abnormal lung lobation (HP:0002101)1.59874888
127Bilateral microphthalmos (HP:0007633)1.59524445
128Ectopic anus (HP:0004397)1.59233550
129Myelomeningocele (HP:0002475)1.58787607
130Chronic hepatic failure (HP:0100626)1.58433343
131Absent septum pellucidum (HP:0001331)1.57897247
132Genital tract atresia (HP:0001827)1.56827700
133Agitation (HP:0000713)1.56692756
134Long eyelashes (HP:0000527)1.56602006
135Preaxial hand polydactyly (HP:0001177)1.56489290
136Overfolded helix (HP:0000396)1.56371557
137Narrow forehead (HP:0000341)1.56353080
138Septo-optic dysplasia (HP:0100842)1.56266331
139Lissencephaly (HP:0001339)1.56189009
140Morphological abnormality of the middle ear (HP:0008609)1.56169893
141Medial flaring of the eyebrow (HP:0010747)1.55373439
142Pancreatic fibrosis (HP:0100732)1.54479197
143Abnormal respiratory motile cilium physiology (HP:0012261)1.53791433
144Narrow palate (HP:0000189)1.53247346
145Hypoplasia of the maxilla (HP:0000327)1.52623214
146Abnormality of the antihelix (HP:0009738)1.52477457
147Intellectual disability, moderate (HP:0002342)1.52026618
148Median cleft lip (HP:0000161)1.50995417
149Patchy hypopigmentation of hair (HP:0011365)1.50987543
150Inappropriate behavior (HP:0000719)1.50673884
151Vaginal atresia (HP:0000148)1.50391797
152Renal hypoplasia (HP:0000089)1.50075113
153Stomach cancer (HP:0012126)1.49704381
154Oligodactyly (hands) (HP:0001180)1.49497943
155Mutism (HP:0002300)1.48462107
156Abnormality of the right ventricle (HP:0001707)1.48433048
157Gait imbalance (HP:0002141)1.47856760
158Omphalocele (HP:0001539)1.47453406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.08427902
2NTRK32.89839657
3TNIK2.72763661
4CASK2.65326250
5MARK12.47886150
6EPHA42.10401052
7BRD42.07724815
8STK391.87633452
9MAPK131.85932370
10TRIM281.84298529
11BCR1.75674575
12SRPK11.75413923
13MKNK21.67280528
14WNK11.64612445
15CDK121.56243731
16MKNK11.55198935
17FRK1.51928270
18CAMK1G1.51826720
19FGFR21.49726749
20AKT31.39746174
21NEK61.39064526
22WEE11.38329092
23ACVR1B1.36243196
24MAP3K41.35717628
25CSNK1A1L1.35257596
26NUAK11.32959438
27YES11.31673341
28ERBB31.28435105
29NTRK21.26652309
30PINK11.19882925
31CDK31.17334203
32BMPR1B1.17060561
33VRK11.16312533
34EPHB21.15681662
35PLK41.13453793
36UHMK11.12875418
37DYRK31.10193308
38MAP3K121.08314717
39SIK21.07101045
40STK38L1.05958200
41OXSR11.04891633
42INSRR1.04232694
43PRKCG1.04009817
44PKN11.03813093
45SGK21.03662410
46CSNK1G31.00123853
47PLK20.99745261
48CDC42BPA0.98794607
49CSNK1G20.97259800
50CLK10.95711725
51SGK2230.92123725
52SGK4940.92123725
53CSNK1G10.92019552
54WNK40.90569035
55PLK30.90130244
56TAF10.89071009
57PRPF4B0.89028659
58RIPK40.88998548
59MAPK150.86313599
60SGK10.84869747
61DYRK1A0.84806302
62PIK3CA0.82733881
63LATS10.82409526
64GRK70.79647965
65DMPK0.78648955
66MAP2K70.78616579
67NEK20.78302872
68ATM0.77181940
69PRKCH0.76377154
70WNK30.76037771
71MAP4K20.75304233
72BMPR20.75049026
73MARK20.73598732
74NEK10.71894149
75STK30.70337795
76SGK30.70062014
77CAMK1D0.69665709
78CDK90.68581646
79FGFR10.68547373
80MAP3K130.66409112
81EIF2AK20.66174497
82PRKCE0.66130104
83ZAK0.65209512
84MAPK140.64671210
85FGR0.64345583
86RPS6KA40.63695878
87CDK50.61972734
88PRKDC0.61519079
89MELK0.61201975
90MAPK100.61065783
91MAP3K90.60992366
92GSK3B0.60920825
93ATR0.60638501
94ADRBK20.60337547
95CSNK1D0.60145518
96DYRK20.60109501
97CAMK2A0.59400604
98PDGFRB0.59312886
99PRKG10.59171939
100CSNK1E0.58615005
101CAMK2B0.58214774
102ROCK20.58165109
103CHEK10.56446893
104PRKCQ0.56343693
105PLK10.55890397
106CDC70.55433731
107CDK10.55280346
108BRSK20.55258409
109MAP3K20.54683405
110TYRO30.54368939
111PAK30.53863195
112IRAK20.53659906
113ERBB20.52016350
114CAMK10.50726473
115MINK10.50503497
116PRKD20.49792957
117MAP2K40.49646990
118STK110.48791422
119GRK10.48207701
120CHEK20.47281431
121KSR10.46898197
122RPS6KB10.46389061
123RPS6KA50.45824838
124TGFBR10.43868805
125NLK0.43441656
126PRKACB0.41724039
127PRKCZ0.41534705
128MAP3K100.40721414
129CSNK1A10.40066512
130STK160.40017538
131NME10.39295709

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.68354187
2Nicotine addiction_Homo sapiens_hsa050332.59753237
3Oxidative phosphorylation_Homo sapiens_hsa001901.85690639
4Glutamatergic synapse_Homo sapiens_hsa047241.84806526
5Homologous recombination_Homo sapiens_hsa034401.81501760
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79121650
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77822693
8Phototransduction_Homo sapiens_hsa047441.77492888
9Axon guidance_Homo sapiens_hsa043601.76329930
10Parkinsons disease_Homo sapiens_hsa050121.72411774
11Morphine addiction_Homo sapiens_hsa050321.68181556
12Serotonergic synapse_Homo sapiens_hsa047261.66274285
13Long-term potentiation_Homo sapiens_hsa047201.64176960
14Long-term depression_Homo sapiens_hsa047301.60849386
15Amphetamine addiction_Homo sapiens_hsa050311.59116612
16Circadian entrainment_Homo sapiens_hsa047131.58452925
17GABAergic synapse_Homo sapiens_hsa047271.52592230
18Cocaine addiction_Homo sapiens_hsa050301.49846912
19Huntingtons disease_Homo sapiens_hsa050161.47248408
20Taste transduction_Homo sapiens_hsa047421.42574130
21Dopaminergic synapse_Homo sapiens_hsa047281.35654521
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34174701
23Renin secretion_Homo sapiens_hsa049241.30342670
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29908508
25Cholinergic synapse_Homo sapiens_hsa047251.28873808
26Dorso-ventral axis formation_Homo sapiens_hsa043201.28083720
27Wnt signaling pathway_Homo sapiens_hsa043101.25580285
28Olfactory transduction_Homo sapiens_hsa047401.24542188
29Alzheimers disease_Homo sapiens_hsa050101.23276817
30Insulin secretion_Homo sapiens_hsa049111.22955999
31Basal cell carcinoma_Homo sapiens_hsa052171.19577319
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18850075
33Non-homologous end-joining_Homo sapiens_hsa034501.16032728
34Fanconi anemia pathway_Homo sapiens_hsa034601.12999574
35Circadian rhythm_Homo sapiens_hsa047101.12117004
36Mismatch repair_Homo sapiens_hsa034301.10428275
37Melanogenesis_Homo sapiens_hsa049161.10061662
38Ribosome_Homo sapiens_hsa030101.09878140
39Propanoate metabolism_Homo sapiens_hsa006401.09689306
40Butanoate metabolism_Homo sapiens_hsa006501.08881977
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06785182
42Salivary secretion_Homo sapiens_hsa049701.06622576
43ErbB signaling pathway_Homo sapiens_hsa040121.05284938
44Prostate cancer_Homo sapiens_hsa052151.04652031
45Type II diabetes mellitus_Homo sapiens_hsa049301.01785396
46cAMP signaling pathway_Homo sapiens_hsa040241.01655720
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01575914
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01235285
49Hedgehog signaling pathway_Homo sapiens_hsa043401.00727841
50Oxytocin signaling pathway_Homo sapiens_hsa049211.00440423
51Renal cell carcinoma_Homo sapiens_hsa052111.00369934
52Alcoholism_Homo sapiens_hsa050340.99668799
53GnRH signaling pathway_Homo sapiens_hsa049120.99130224
54MAPK signaling pathway_Homo sapiens_hsa040100.99120446
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98760186
56RNA transport_Homo sapiens_hsa030130.96720936
57mRNA surveillance pathway_Homo sapiens_hsa030150.94654839
58Calcium signaling pathway_Homo sapiens_hsa040200.93305792
59Ether lipid metabolism_Homo sapiens_hsa005650.92538334
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91997127
61Gastric acid secretion_Homo sapiens_hsa049710.90790466
62Colorectal cancer_Homo sapiens_hsa052100.89830231
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88655693
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87260599
65Nucleotide excision repair_Homo sapiens_hsa034200.84886803
66MicroRNAs in cancer_Homo sapiens_hsa052060.84581338
67Nitrogen metabolism_Homo sapiens_hsa009100.84352482
68Ras signaling pathway_Homo sapiens_hsa040140.84026458
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83642284
70Estrogen signaling pathway_Homo sapiens_hsa049150.83622960
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82595130
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82262608
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80866999
74Glioma_Homo sapiens_hsa052140.80554625
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.80388860
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80346513
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.80167082
78Choline metabolism in cancer_Homo sapiens_hsa052310.79588982
79Melanoma_Homo sapiens_hsa052180.79483125
80Basal transcription factors_Homo sapiens_hsa030220.76349861
81Gap junction_Homo sapiens_hsa045400.76285084
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76058434
83Selenocompound metabolism_Homo sapiens_hsa004500.75359577
84Oocyte meiosis_Homo sapiens_hsa041140.75067079
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71341517
86T cell receptor signaling pathway_Homo sapiens_hsa046600.71249337
87Pathways in cancer_Homo sapiens_hsa052000.69970887
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69266210
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68866009
90Dilated cardiomyopathy_Homo sapiens_hsa054140.68435666
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68015272
92Rap1 signaling pathway_Homo sapiens_hsa040150.66873778
93TGF-beta signaling pathway_Homo sapiens_hsa043500.65499540
94Adherens junction_Homo sapiens_hsa045200.65177521
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64880658
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64790622
97Hippo signaling pathway_Homo sapiens_hsa043900.64007577
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.63197348
99Lysine degradation_Homo sapiens_hsa003100.62186532
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62027903
101Endometrial cancer_Homo sapiens_hsa052130.60118749
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59140439
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59097695
104Steroid biosynthesis_Homo sapiens_hsa001000.58288840
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58033702
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57386412
107Ovarian steroidogenesis_Homo sapiens_hsa049130.57342434
108Sphingolipid metabolism_Homo sapiens_hsa006000.57161033
109RNA polymerase_Homo sapiens_hsa030200.55307019
110Spliceosome_Homo sapiens_hsa030400.55134080
111RNA degradation_Homo sapiens_hsa030180.54404347
112Linoleic acid metabolism_Homo sapiens_hsa005910.53844519
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53832527
114Inositol phosphate metabolism_Homo sapiens_hsa005620.53778478
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52755586
116Regulation of autophagy_Homo sapiens_hsa041400.51990982
117Autoimmune thyroid disease_Homo sapiens_hsa053200.51848401
118Chemokine signaling pathway_Homo sapiens_hsa040620.51659904
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.51435818
120Pancreatic secretion_Homo sapiens_hsa049720.50788640
121Tight junction_Homo sapiens_hsa045300.50279965
122Cell cycle_Homo sapiens_hsa041100.49652686
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49437435
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48809550
125Cardiac muscle contraction_Homo sapiens_hsa042600.47295100
126Thyroid hormone synthesis_Homo sapiens_hsa049180.46707312
127Notch signaling pathway_Homo sapiens_hsa043300.45083542
128Synaptic vesicle cycle_Homo sapiens_hsa047210.43316567
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41665389
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39960504

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