RSG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pentose-phosphate shunt (GO:0006098)6.07377966
2NADPH regeneration (GO:0006740)5.29872720
3glucose catabolic process (GO:0006007)4.99988607
4Golgi transport vesicle coating (GO:0048200)4.97030753
5COPI coating of Golgi vesicle (GO:0048205)4.97030753
6negative regulation of erythrocyte differentiation (GO:0045647)4.68458881
7dopamine transport (GO:0015872)4.34538072
8protein localization to endosome (GO:0036010)4.31559016
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.11084175
10protein neddylation (GO:0045116)4.10049941
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05056752
12peptidyl-tyrosine autophosphorylation (GO:0038083)4.01631229
13neuron cell-cell adhesion (GO:0007158)4.01163848
14protein retention in ER lumen (GO:0006621)4.00466454
15presynaptic membrane assembly (GO:0097105)3.96299504
16long-chain fatty acid biosynthetic process (GO:0042759)3.89885598
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.88928462
18peptidyl-proline hydroxylation (GO:0019511)3.87480604
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.80014969
20proline biosynthetic process (GO:0006561)3.73822611
21axon ensheathment in central nervous system (GO:0032291)3.69034170
22central nervous system myelination (GO:0022010)3.69034170
23intracellular estrogen receptor signaling pathway (GO:0030520)3.63064794
244-hydroxyproline metabolic process (GO:0019471)3.62785265
25presynaptic membrane organization (GO:0097090)3.53912005
26protein insertion into membrane (GO:0051205)3.52396218
27regulation of early endosome to late endosome transport (GO:2000641)3.50416742
28nucleoside diphosphate catabolic process (GO:0009134)3.50247195
29dopamine biosynthetic process (GO:0042416)3.45517800
30respiratory chain complex IV assembly (GO:0008535)3.37944621
31response to muramyl dipeptide (GO:0032495)3.29097567
32regulation of glucose import in response to insulin stimulus (GO:2001273)3.29023745
33protein complex biogenesis (GO:0070271)3.27963035
34snRNA metabolic process (GO:0016073)3.23266208
35response to peptidoglycan (GO:0032494)3.22026063
36pentose metabolic process (GO:0019321)3.21404267
37mannosylation (GO:0097502)3.20827894
38apoptotic process involved in morphogenesis (GO:0060561)3.18967719
39regulation of chromatin binding (GO:0035561)3.18115970
40negative regulation of catenin import into nucleus (GO:0035414)3.17963566
41positive regulation of protein homodimerization activity (GO:0090073)3.16019211
42UV protection (GO:0009650)3.13222442
43regulation of RNA export from nucleus (GO:0046831)3.13198984
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12165590
45ATP synthesis coupled proton transport (GO:0015986)3.12165590
46barbed-end actin filament capping (GO:0051016)3.10968841
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10426602
48ribosomal small subunit biogenesis (GO:0042274)3.09216325
49regulation of translational fidelity (GO:0006450)3.07571758
50cytochrome complex assembly (GO:0017004)3.06734208
51protein hydroxylation (GO:0018126)3.06514702
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.05020382
53cell-substrate adherens junction assembly (GO:0007045)3.04651030
54focal adhesion assembly (GO:0048041)3.04651030
55developmental pigmentation (GO:0048066)3.01829627
56GPI anchor biosynthetic process (GO:0006506)3.01166837
57termination of RNA polymerase III transcription (GO:0006386)3.01011793
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.01011793
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.98846253
60adherens junction assembly (GO:0034333)2.98738734
61NADP metabolic process (GO:0006739)2.97385548
62regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96746028
63preassembly of GPI anchor in ER membrane (GO:0016254)2.96120116
64negative regulation of cell size (GO:0045792)2.95080607
65peptidyl-histidine modification (GO:0018202)2.93967624
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92243073
67chaperone-mediated protein transport (GO:0072321)2.91827017
68protein-cofactor linkage (GO:0018065)2.91264983
69positive regulation of nuclease activity (GO:0032075)2.91008802
70regulation of nucleobase-containing compound transport (GO:0032239)2.90353053
71DNA unwinding involved in DNA replication (GO:0006268)2.87278217
72maternal placenta development (GO:0001893)2.86172946
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.85938044
74pinocytosis (GO:0006907)2.82074068
75sexual reproduction (GO:0019953)2.81283175
76epithelial cell-cell adhesion (GO:0090136)2.81099435
77negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.80772971
78mitochondrial respiratory chain complex assembly (GO:0033108)2.80668187
79urea cycle (GO:0000050)2.80505890
803-UTR-mediated mRNA stabilization (GO:0070935)2.78951886
817-methylguanosine RNA capping (GO:0009452)2.78945652
82RNA capping (GO:0036260)2.78945652
83mitochondrial fusion (GO:0008053)2.78131330
84cell-substrate junction assembly (GO:0007044)2.77956320
85peptidyl-arginine omega-N-methylation (GO:0035247)2.77894417
86GPI anchor metabolic process (GO:0006505)2.77850881
87respiratory electron transport chain (GO:0022904)2.77383616
88snRNA processing (GO:0016180)2.76704131
89regulation of dopamine metabolic process (GO:0042053)2.76540672
90regulation of catecholamine metabolic process (GO:0042069)2.76540672
91modulation by virus of host process (GO:0019054)2.76380698
92NADH dehydrogenase complex assembly (GO:0010257)2.75398890
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75398890
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.75398890
95DNA damage response, detection of DNA damage (GO:0042769)2.73822954
967-methylguanosine mRNA capping (GO:0006370)2.72952365
97GTP biosynthetic process (GO:0006183)2.72675549
98modulation by symbiont of host cellular process (GO:0044068)2.72533646
99keratinocyte development (GO:0003334)2.71387007
100activation of Rac GTPase activity (GO:0032863)2.70089255
101postsynaptic membrane organization (GO:0001941)2.69344846
102electron transport chain (GO:0022900)2.68336401
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67998775
104negative regulation of neurotransmitter transport (GO:0051589)2.67442601
105endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66441839
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.66156088
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65288015
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63850741
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63850741
110microtubule polymerization or depolymerization (GO:0031109)2.63842060
111protein maturation by protein folding (GO:0022417)2.63756507
112startle response (GO:0001964)2.63743050
113intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.60333146
114lymph vessel development (GO:0001945)2.60140583
115peptidyl-lysine dimethylation (GO:0018027)2.58433689
116regulation of nuclease activity (GO:0032069)2.57503791
117mitotic chromosome condensation (GO:0007076)2.57190078
118adenosine metabolic process (GO:0046085)2.56517478
119righting reflex (GO:0060013)2.53680519
120neuron remodeling (GO:0016322)2.53136171
121proline metabolic process (GO:0006560)2.52662191
122positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.52229308
123regulation of pigment cell differentiation (GO:0050932)2.52008570
124superoxide anion generation (GO:0042554)2.51725782
125regulation of histone H3-K27 methylation (GO:0061085)2.51621833
126nuclear pore complex assembly (GO:0051292)2.51538104
127mitotic nuclear envelope reassembly (GO:0007084)2.50725992
128nuclear envelope reassembly (GO:0031468)2.50725992
129detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50501012
130endoplasmic reticulum unfolded protein response (GO:0030968)2.50146129
131negative regulation of myoblast differentiation (GO:0045662)2.49674377
132neuronal action potential propagation (GO:0019227)2.49126421
133hyaluronan catabolic process (GO:0030214)2.48472614
134urea metabolic process (GO:0019627)2.47909159
135stress fiber assembly (GO:0043149)2.47593347
136activation of MAPKKK activity (GO:0000185)2.46823431
137transcription elongation from RNA polymerase I promoter (GO:0006362)2.46478852
138deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.46404244
139protein-DNA complex disassembly (GO:0032986)2.46052451
140nucleosome disassembly (GO:0006337)2.46052451
141transmission of nerve impulse (GO:0019226)2.45945636
142motile cilium assembly (GO:0044458)2.45503863
143C-terminal protein lipidation (GO:0006501)2.43905481
144regulation of response to osmotic stress (GO:0047484)2.43461402
145mRNA stabilization (GO:0048255)2.43210511
146RNA stabilization (GO:0043489)2.43210511
147lymphoid progenitor cell differentiation (GO:0002320)2.42603036
148protein localization to cilium (GO:0061512)2.41993202
149ionotropic glutamate receptor signaling pathway (GO:0035235)2.40126835
150face development (GO:0060324)2.40111085
151microtubule depolymerization (GO:0007019)2.39738974
152modulation by virus of host morphology or physiology (GO:0019048)2.39051375
153intraciliary transport (GO:0042073)2.37892309
154glucose 6-phosphate metabolic process (GO:0051156)2.37791570
155CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.37749331
156axonemal dynein complex assembly (GO:0070286)2.37708557
157C-terminal protein amino acid modification (GO:0018410)2.37321681
158positive regulation of extracellular matrix organization (GO:1903055)2.37207257
159regulation of mitochondrial translation (GO:0070129)2.36869046
160glycerophospholipid catabolic process (GO:0046475)2.36837671
161natural killer cell activation involved in immune response (GO:0002323)2.36389684
162protoporphyrinogen IX metabolic process (GO:0046501)2.35697084
163ER-nucleus signaling pathway (GO:0006984)2.34735877
164embryonic process involved in female pregnancy (GO:0060136)2.34507878
165cellular response to unfolded protein (GO:0034620)2.33558588
166opioid receptor signaling pathway (GO:0038003)2.33555706
167regulation of nuclear cell cycle DNA replication (GO:0033262)2.33474871
168isoprenoid biosynthetic process (GO:0008299)2.33324341
169cellular response to nerve growth factor stimulus (GO:1990090)2.33041614
170response to nerve growth factor (GO:1990089)2.33041614
171chaperone mediated protein folding requiring cofactor (GO:0051085)2.32858902
172detection of light stimulus involved in sensory perception (GO:0050962)2.32332255
173detection of light stimulus involved in visual perception (GO:0050908)2.32332255
174establishment of protein localization to mitochondrial membrane (GO:0090151)2.32286800
175serotonin receptor signaling pathway (GO:0007210)2.32270108
176response to thyroid hormone (GO:0097066)2.32159759
177proteasome assembly (GO:0043248)2.31635228
178regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31164827
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.30303245
180nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30004016
181establishment of integrated proviral latency (GO:0075713)2.29909642
182CENP-A containing nucleosome assembly (GO:0034080)2.29137844
183deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.26930367
184deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.26713415
185catecholamine transport (GO:0051937)2.25480598
186viral protein processing (GO:0019082)2.24918728
187negative regulation of exocytosis (GO:0045920)2.24366592
188catechol-containing compound biosynthetic process (GO:0009713)2.24100770
189catecholamine biosynthetic process (GO:0042423)2.24100770
190termination of RNA polymerase I transcription (GO:0006363)2.23619555
191tRNA processing (GO:0008033)2.23576775
192glutamate receptor signaling pathway (GO:0007215)2.23370873
193response to redox state (GO:0051775)2.19019086
194kinetochore assembly (GO:0051382)2.18523917
195regulation of feeding behavior (GO:0060259)2.18515624
196DNA integration (GO:0015074)2.15803461
197exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.14152684
198reflex (GO:0060004)2.12338076
199positive regulation of synapse assembly (GO:0051965)2.12123130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.68601195
2EZH2_22144423_ChIP-Seq_EOC_Human3.20849572
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96359353
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87484528
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83406245
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81614716
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78805991
8VDR_21846776_ChIP-Seq_THP-1_Human2.74449255
9MYC_22102868_ChIP-Seq_BL_Human2.73011516
10VDR_22108803_ChIP-Seq_LS180_Human2.70399567
11TAF15_26573619_Chip-Seq_HEK293_Human2.68890246
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66430203
13LXR_22292898_ChIP-Seq_THP-1_Human2.63739689
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.60209858
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55546978
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48520018
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43637858
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41963143
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.41271108
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27306695
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22758403
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21205886
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18572313
24RACK7_27058665_Chip-Seq_MCF-7_Human2.18199465
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.11759519
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03651900
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97555740
28FUS_26573619_Chip-Seq_HEK293_Human1.95574289
29P300_19829295_ChIP-Seq_ESCs_Human1.90959604
30E2F7_22180533_ChIP-Seq_HELA_Human1.86151134
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83870091
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83126545
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80931257
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79622081
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79120303
36TCF7_22412390_ChIP-Seq_EML_Mouse1.79022334
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.77215886
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74360884
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73928601
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.72308621
41KDM2B_26808549_Chip-Seq_DND41_Human1.71316679
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70955963
43ZNF263_19887448_ChIP-Seq_K562_Human1.70248666
44RNF2_27304074_Chip-Seq_NSC_Mouse1.70129607
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.70093630
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69605041
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68745444
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64145113
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63376804
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61890358
51KDM2B_26808549_Chip-Seq_K562_Human1.61673683
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61384749
53P68_20966046_ChIP-Seq_HELA_Human1.59909121
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.59896553
55EWS_26573619_Chip-Seq_HEK293_Human1.59818329
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59040140
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58479514
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.58136404
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.58105559
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57657958
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.57526920
62ER_23166858_ChIP-Seq_MCF-7_Human1.57303015
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57099394
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54718822
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.53956489
66XRN2_22483619_ChIP-Seq_HELA_Human1.53523762
67VDR_24763502_ChIP-Seq_THP-1_Human1.53090418
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51125235
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.50933787
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50889524
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.49280245
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48127192
73NCOR1_26117541_ChIP-Seq_K562_Human1.47521207
74IRF1_19129219_ChIP-ChIP_H3396_Human1.47214139
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47076687
76MAF_26560356_Chip-Seq_TH1_Human1.46519515
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45874458
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45695112
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.45050663
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44880400
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44451074
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44212475
83SMC4_20622854_ChIP-Seq_HELA_Human1.44076611
84P53_22387025_ChIP-Seq_ESCs_Mouse1.43563565
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.43060703
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43038266
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.42921277
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42590465
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42335352
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.41471732
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.41073492
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40954841
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40379681
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40134571
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.39043178
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38518647
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38286805
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37642841
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.37434362
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37330447
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37307642
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36838052
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35771996
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35556140
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35474620
106P300_18555785_Chip-Seq_ESCs_Mouse1.35062616
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.34191919
108CREB1_26743006_Chip-Seq_LNCaP_Human1.34072983
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34068500
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33578965
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32707908
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32210346
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31850141
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31796686
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.31706648
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31670238
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31413587
118IGF1R_20145208_ChIP-Seq_DFB_Human1.31091303
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30528651
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30227857
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.29884824
122MAF_26560356_Chip-Seq_TH2_Human1.29866854
123ATF3_27146783_Chip-Seq_COLON_Human1.29650513
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29541277
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.29448159
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.29131851
127MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28164530
128STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27618666
129SMAD4_21799915_ChIP-Seq_A2780_Human1.27551915
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26833366
131UTX_26944678_Chip-Seq_JUKART_Human1.26792272
132PIAS1_25552417_ChIP-Seq_VCAP_Human1.25364161
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25335412
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24493524
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24147852
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22818231
137RUNX1_22412390_ChIP-Seq_EML_Mouse1.22535980
138GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22418779
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22354470
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22319715
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22173261
142BCOR_27268052_Chip-Seq_Bcells_Human1.20968939
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20699771
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20651082
145JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19873033
146ERG_21242973_ChIP-ChIP_JURKAT_Human1.19702635
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19494488
148SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18826878
149ZFX_18555785_Chip-Seq_ESCs_Mouse1.18540408
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18522128
151SMAD3_21741376_ChIP-Seq_EPCs_Human1.18298102
152GATA1_19941826_ChIP-Seq_K562_Human1.17340132
153OCT4_18555785_Chip-Seq_ESCs_Mouse1.16549391
154ELK1_19687146_ChIP-ChIP_HELA_Human1.16148455
155SRF_21415370_ChIP-Seq_HL-1_Mouse1.16084313
156KLF4_18555785_Chip-Seq_ESCs_Mouse1.15827692
157REST_21632747_ChIP-Seq_MESCs_Mouse1.15786011
158TP53_22127205_ChIP-Seq_IMR90_Human1.15269801
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15257602
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14832574
161RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14700066
162SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13986159
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13620164
164CLOCK_20551151_ChIP-Seq_293T_Human1.13056563
165STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12854101
166CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12710954
167MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12643536
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12460241
169EZH2_27294783_Chip-Seq_ESCs_Mouse1.12019132
170FOXM1_23109430_ChIP-Seq_U2OS_Human1.11454452
171HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10904736
172PU1_27457419_Chip-Seq_LIVER_Mouse1.10014408
173SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09905390
174CTCF_21964334_Chip-Seq_Bcells_Human1.09808319
175NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08915195
176SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08345501
177PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07204563
178RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06915072
179EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06915072
180RNF2_27304074_Chip-Seq_ESCs_Mouse1.06910314
181PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06452982
182BCL6_27268052_Chip-Seq_Bcells_Human1.06139953
183CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05681521
184ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05652309
185MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05187210
186SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04733023
187CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03441490
188RUNX1_27514584_Chip-Seq_MCF-7_Human1.02833513
189SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02757622
190RUNX2_22187159_ChIP-Seq_PCA_Human1.02358993
191CTCF_18555785_Chip-Seq_ESCs_Mouse1.02057188
192CRX_20693478_ChIP-Seq_RETINA_Mouse1.01463479
193BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01418846
194MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01377726
195NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01355147
196ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01123166
197SMAD_19615063_ChIP-ChIP_OVARY_Human0.98985005
198SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98429137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.74758999
2MP0006292_abnormal_olfactory_placode3.91816655
3MP0001188_hyperpigmentation3.86912707
4MP0003880_abnormal_central_pattern3.75247896
5MP0001986_abnormal_taste_sensitivity3.27697881
6MP0004233_abnormal_muscle_weight3.10475885
7MP0005076_abnormal_cell_differentiation3.01636242
8MP0000566_synostosis3.00076857
9MP0008438_abnormal_cutaneous_collagen2.84655293
10MP0003566_abnormal_cell_adhesion2.83372977
11MP0005423_abnormal_somatic_nervous2.83014473
12MP0001529_abnormal_vocalization2.75089998
13MP0005058_abnormal_lysosome_morphology2.65301535
14MP0005451_abnormal_body_composition2.59611731
15MP0003136_yellow_coat_color2.55904039
16MP0005171_absent_coat_pigmentation2.52024289
17MP0009379_abnormal_foot_pigmentation2.49036939
18MP0010234_abnormal_vibrissa_follicle2.46524127
19MP0001905_abnormal_dopamine_level2.29870281
20MP0001849_ear_inflammation2.29861464
21MP0004381_abnormal_hair_follicle2.26195049
22MP0006276_abnormal_autonomic_nervous2.21044273
23MP0004858_abnormal_nervous_system2.17768028
24MP0005409_darkened_coat_color2.07528941
25MP0004185_abnormal_adipocyte_glucose2.05361828
26MP0003091_abnormal_cell_migration2.01225602
27MP0002877_abnormal_melanocyte_morpholog2.00624811
28MP0002736_abnormal_nociception_after1.97837953
29MP0000678_abnormal_parathyroid_gland1.95708796
30MP0003111_abnormal_nucleus_morphology1.94896757
31MP0002735_abnormal_chemical_nociception1.86534134
32MP0002638_abnormal_pupillary_reflex1.85639575
33MP0005623_abnormal_meninges_morphology1.85588816
34MP0005075_abnormal_melanosome_morpholog1.83727328
35MP0004742_abnormal_vestibular_system1.83149995
36MP0001968_abnormal_touch/_nociception1.82485626
37MP0001486_abnormal_startle_reflex1.82043112
38MP0000537_abnormal_urethra_morphology1.79484332
39MP0009046_muscle_twitch1.75846378
40MP0002272_abnormal_nervous_system1.75041044
41MP0009745_abnormal_behavioral_response1.74650214
42MP0004142_abnormal_muscle_tone1.74442707
43MP0000372_irregular_coat_pigmentation1.72992587
44MP0002163_abnormal_gland_morphology1.70623519
45MP0003453_abnormal_keratinocyte_physiol1.69665879
46MP0005501_abnormal_skin_physiology1.68413011
47MP0002102_abnormal_ear_morphology1.61262612
48MP0004272_abnormal_basement_membrane1.60038840
49MP0002796_impaired_skin_barrier1.58817382
50MP0000858_altered_metastatic_potential1.58681158
51MP0005379_endocrine/exocrine_gland_phen1.58290395
52MP0002876_abnormal_thyroid_physiology1.55658999
53MP0002064_seizures1.53428514
54MP0002249_abnormal_larynx_morphology1.53320041
55MP0009840_abnormal_foam_cell1.49557054
56MP0002572_abnormal_emotion/affect_behav1.48937706
57MP0008057_abnormal_DNA_replication1.48930422
58MP0001348_abnormal_lacrimal_gland1.48296174
59MP0002277_abnormal_respiratory_mucosa1.46136353
60MP0005257_abnormal_intraocular_pressure1.44673171
61MP0000733_abnormal_muscle_development1.43516045
62MP0005645_abnormal_hypothalamus_physiol1.43328834
63MP0000015_abnormal_ear_pigmentation1.43152031
64MP0009278_abnormal_bone_marrow1.43036697
65MP0003763_abnormal_thymus_physiology1.42382499
66MP0003635_abnormal_synaptic_transmissio1.42156679
67MP0005551_abnormal_eye_electrophysiolog1.40482668
68MP0001958_emphysema1.38271138
69MP0005621_abnormal_cell_physiology1.38054842
70MP0001984_abnormal_olfaction1.35889716
71MP0005174_abnormal_tail_pigmentation1.34903708
72MP0010307_abnormal_tumor_latency1.34880701
73MP0001730_embryonic_growth_arrest1.34574706
74MP0005646_abnormal_pituitary_gland1.32706289
75MP0003300_gastrointestinal_ulcer1.32262127
76MP0003724_increased_susceptibility_to1.31450862
77MP0002067_abnormal_sensory_capabilities1.30114426
78MP0003172_abnormal_lysosome_physiology1.29928681
79MP0004957_abnormal_blastocyst_morpholog1.28245073
80MP0000920_abnormal_myelination1.27961095
81MP0002060_abnormal_skin_morphology1.26557266
82MP0002938_white_spotting1.25829412
83MP0001501_abnormal_sleep_pattern1.21381793
84MP0004808_abnormal_hematopoietic_stem1.19267448
85MP0008058_abnormal_DNA_repair1.18738047
86MP0002080_prenatal_lethality1.17692475
87MP0003279_aneurysm1.17573747
88MP0002734_abnormal_mechanical_nocicepti1.17314162
89MP0001440_abnormal_grooming_behavior1.16573048
90MP0002063_abnormal_learning/memory/cond1.15582094
91MP0000350_abnormal_cell_proliferation1.15209961
92MP0001485_abnormal_pinna_reflex1.14863733
93MP0005253_abnormal_eye_physiology1.14467649
94MP0003303_peritoneal_inflammation1.13792203
95MP0001963_abnormal_hearing_physiology1.13583694
96MP0010352_gastrointestinal_tract_polyps1.13217198
97MP0000026_abnormal_inner_ear1.12982433
98MP0002184_abnormal_innervation1.12032664
99MP0005083_abnormal_biliary_tract1.11868822
100MP0002148_abnormal_hypersensitivity_rea1.11573161
101MP0000490_abnormal_crypts_of1.10664989
102MP0003191_abnormal_cellular_cholesterol1.09172604
103MP0000747_muscle_weakness1.09170452
104MP0009931_abnormal_skin_appearance1.09167428
105MP0008877_abnormal_DNA_methylation1.09014658
106MP0003077_abnormal_cell_cycle1.08675588
107MP0003787_abnormal_imprinting1.08090383
108MP0003942_abnormal_urinary_system1.07833245
109MP0002557_abnormal_social/conspecific_i1.06481905
110MP0000467_abnormal_esophagus_morphology1.05863199
111MP0010386_abnormal_urinary_bladder1.05615621
112MP0004947_skin_inflammation1.05414368
113MP0003656_abnormal_erythrocyte_physiolo1.05121736
114MP0004859_abnormal_synaptic_plasticity1.04892069
115MP0000778_abnormal_nervous_system1.04795465
116MP0001970_abnormal_pain_threshold1.03419239
117MP0002086_abnormal_extraembryonic_tissu1.03414959
118MP0003938_abnormal_ear_development1.02566539
119MP0002396_abnormal_hematopoietic_system1.02284267
120MP0005384_cellular_phenotype1.01506536
121MP0002095_abnormal_skin_pigmentation0.99894986
122MP0005464_abnormal_platelet_physiology0.99617317
123MP0008995_early_reproductive_senescence0.98928812
124MP0001502_abnormal_circadian_rhythm0.98221265
125MP0008260_abnormal_autophagy0.97990524
126MP0003718_maternal_effect0.97941890
127MP0004270_analgesia0.97303805
128MP0000313_abnormal_cell_death0.97270828
129MP0008007_abnormal_cellular_replicative0.96886933
130MP0009697_abnormal_copulation0.96449272
131MP0006072_abnormal_retinal_apoptosis0.96135377
132MP0005023_abnormal_wound_healing0.95779214
133MP0004264_abnormal_extraembryonic_tissu0.94187770
134MP0000767_abnormal_smooth_muscle0.92489140
135MP0010030_abnormal_orbit_morphology0.91981580
136MP0003941_abnormal_skin_development0.91980526
137MP0000759_abnormal_skeletal_muscle0.90927554
138MP0002085_abnormal_embryonic_tissue0.90847616
139MP0002752_abnormal_somatic_nervous0.90412802
140MP0001664_abnormal_digestion0.90050903
141MP0004924_abnormal_behavior0.89152351
142MP0005386_behavior/neurological_phenoty0.89152351
143MP0001216_abnormal_epidermal_layer0.89117621
144MP0008932_abnormal_embryonic_tissue0.87450403
145MP0003436_decreased_susceptibility_to0.87365103
146MP0002653_abnormal_ependyma_morphology0.86852553
147MP0002009_preneoplasia0.86578581
148MP0002896_abnormal_bone_mineralization0.84878727
149MP0003693_abnormal_embryo_hatching0.84207364
150MP0000631_abnormal_neuroendocrine_gland0.84056330
151MP0004782_abnormal_surfactant_physiolog0.83938536
152MP0001661_extended_life_span0.83206691
153MP0009333_abnormal_splenocyte_physiolog0.83191876
154MP0000465_gastrointestinal_hemorrhage0.82799062
155MP0000534_abnormal_ureter_morphology0.82704812
156MP0002751_abnormal_autonomic_nervous0.82593203
157MP0000358_abnormal_cell_content/0.82090932
158MP0001672_abnormal_embryogenesis/_devel0.82087652
159MP0005380_embryogenesis_phenotype0.82087652
160MP0004147_increased_porphyrin_level0.81410566
161MP0002132_abnormal_respiratory_system0.80311659
162MP0001915_intracranial_hemorrhage0.80154814
163MP0000377_abnormal_hair_follicle0.78503182
164MP0000003_abnormal_adipose_tissue0.78379651
165MP0005397_hematopoietic_system_phenotyp0.78265947
166MP0001545_abnormal_hematopoietic_system0.78265947
167MP0004145_abnormal_muscle_electrophysio0.78227631
168MP0008789_abnormal_olfactory_epithelium0.77977044
169MP0003984_embryonic_growth_retardation0.77132641
170MP0004133_heterotaxia0.76618991
171MP0001697_abnormal_embryo_size0.76574733
172MP0005508_abnormal_skeleton_morphology0.76420998
173MP0002733_abnormal_thermal_nociception0.75940274
174MP0009672_abnormal_birth_weight0.75487716
175MP0005408_hypopigmentation0.74846350
176MP0002269_muscular_atrophy0.73557126
177MP0009053_abnormal_anal_canal0.73459710
178MP0002229_neurodegeneration0.73444033
179MP0003329_amyloid_beta_deposits0.73169901
180MP0000762_abnormal_tongue_morphology0.73080431
181MP0002882_abnormal_neuron_morphology0.73068260
182MP0002084_abnormal_developmental_patter0.73000921
183MP0000462_abnormal_digestive_system0.70323297
184MP0002088_abnormal_embryonic_growth/wei0.69722050
185MP0005410_abnormal_fertilization0.67353480
186MP0002066_abnormal_motor_capabilities/c0.67162019
187MP0000681_abnormal_thyroid_gland0.67047960
188MP0003786_premature_aging0.66853957
189MP0009785_altered_susceptibility_to0.66807827
190MP0001346_abnormal_lacrimal_gland0.66513894
191MP0003950_abnormal_plasma_membrane0.66039607
192MP0005310_abnormal_salivary_gland0.64641218
193MP0000049_abnormal_middle_ear0.64380390
194MP0005394_taste/olfaction_phenotype0.60121488
195MP0005499_abnormal_olfactory_system0.60121488

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)4.20762857
2Premature rupture of membranes (HP:0001788)4.09804957
3Abnormality of the renal collecting system (HP:0004742)3.76894315
4Atelectasis (HP:0100750)3.67404752
5Progressive muscle weakness (HP:0003323)3.59918638
6Reticulocytosis (HP:0001923)3.56183448
7Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42201700
8Renal Fanconi syndrome (HP:0001994)3.32701182
9Increased hepatocellular lipid droplets (HP:0006565)3.31145375
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.19661983
11Long palpebral fissure (HP:0000637)3.19318538
12Hyperacusis (HP:0010780)3.18639580
13Protrusio acetabuli (HP:0003179)3.10414525
14Mitochondrial inheritance (HP:0001427)3.09611175
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08956622
16Short nail (HP:0001799)3.02733261
17Parakeratosis (HP:0001036)3.01696968
18Acute necrotizing encephalopathy (HP:0006965)2.98583872
19Nasal polyposis (HP:0100582)2.96558438
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92881246
21Hypothermia (HP:0002045)2.83217579
22Medial flaring of the eyebrow (HP:0010747)2.80565855
23Abnormality of the nasal mucosa (HP:0000433)2.80038395
24Insomnia (HP:0100785)2.79651063
25Upper limb amyotrophy (HP:0009129)2.78763320
26Distal upper limb amyotrophy (HP:0007149)2.78763320
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76338607
28Abnormality of secondary sexual hair (HP:0009888)2.72494690
29Abnormality of the axillary hair (HP:0100134)2.72494690
30Abnormality of the distal phalanges of the toes (HP:0010182)2.72099276
31Seborrheic dermatitis (HP:0001051)2.71951405
32Easy fatigability (HP:0003388)2.71721253
33Premature skin wrinkling (HP:0100678)2.66351663
34Male infertility (HP:0003251)2.56830552
35Disproportionate tall stature (HP:0001519)2.56246240
36Lipid accumulation in hepatocytes (HP:0006561)2.55797312
37Chromsome breakage (HP:0040012)2.55713722
38Limb dystonia (HP:0002451)2.55707543
39Abnormality of renal resorption (HP:0011038)2.55442616
40Hyperthyroidism (HP:0000836)2.54446818
41Hepatocellular necrosis (HP:0001404)2.53996485
42Sensory axonal neuropathy (HP:0003390)2.53764480
43Increased CSF lactate (HP:0002490)2.49630850
44Broad distal phalanx of finger (HP:0009836)2.48456408
45Exertional dyspnea (HP:0002875)2.47536914
46Hypertensive crisis (HP:0100735)2.47396294
47Pancreatic fibrosis (HP:0100732)2.45695428
48Ulnar bowing (HP:0003031)2.45606966
49Progressive macrocephaly (HP:0004481)2.44248127
50Increased connective tissue (HP:0009025)2.43541404
51Abnormal ciliary motility (HP:0012262)2.42957474
52Congenital sensorineural hearing impairment (HP:0008527)2.40401192
533-Methylglutaconic aciduria (HP:0003535)2.39497421
54Absent/shortened dynein arms (HP:0200106)2.37941952
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.37941952
56Nephrogenic diabetes insipidus (HP:0009806)2.37691369
57Truncus arteriosus (HP:0001660)2.37220660
58Abnormality of reticulocytes (HP:0004312)2.36223285
59Gait imbalance (HP:0002141)2.36132348
60Conical tooth (HP:0000698)2.35634081
61Abnormality of dentin (HP:0010299)2.35372657
62Congenital primary aphakia (HP:0007707)2.35117359
63True hermaphroditism (HP:0010459)2.34810000
64Abnormal mitochondria in muscle tissue (HP:0008316)2.34782200
65Cellulitis (HP:0100658)2.34604628
66Osteomalacia (HP:0002749)2.33143832
67Achilles tendon contracture (HP:0001771)2.32996663
68White forelock (HP:0002211)2.31702214
69Abnormal respiratory epithelium morphology (HP:0012253)2.31082191
70Abnormal respiratory motile cilium morphology (HP:0005938)2.31082191
71Vertebral compression fractures (HP:0002953)2.29874165
72Abnormal hair whorl (HP:0010721)2.29590428
73Abnormal gallbladder physiology (HP:0012438)2.29132853
74Cholecystitis (HP:0001082)2.29132853
75Hand muscle atrophy (HP:0009130)2.28066294
76Type I transferrin isoform profile (HP:0003642)2.27427655
77Cervical subluxation (HP:0003308)2.25019240
78Dilatation of the ascending aorta (HP:0005111)2.24477678
79Mildly elevated creatine phosphokinase (HP:0008180)2.24213283
80Sparse lateral eyebrow (HP:0005338)2.22883186
81Patchy hypopigmentation of hair (HP:0011365)2.22090251
82Congenital stationary night blindness (HP:0007642)2.21566280
83Abnormality of the umbilical cord (HP:0010881)2.21510048
84Fragile skin (HP:0001030)2.21101265
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19472037
86Bowel incontinence (HP:0002607)2.19023065
87Generalized amyotrophy (HP:0003700)2.17500459
88Hypoparathyroidism (HP:0000829)2.17317222
89Hyperparathyroidism (HP:0000843)2.15788305
90Optic disc pallor (HP:0000543)2.15352130
91Asplenia (HP:0001746)2.15041974
92Genital tract atresia (HP:0001827)2.12895134
93Pancreatic cysts (HP:0001737)2.09996110
94Thin bony cortex (HP:0002753)2.09378461
95Febrile seizures (HP:0002373)2.08515807
96Vaginal atresia (HP:0000148)2.07678297
97Broad face (HP:0000283)2.07467966
98Prostate neoplasm (HP:0100787)2.07337712
99Abnormality of the preputium (HP:0100587)2.05275234
100Nasolacrimal duct obstruction (HP:0000579)2.05235747
101Abnormal large intestine physiology (HP:0012700)2.02290330
102Patellar dislocation (HP:0002999)2.01791209
103Ragged-red muscle fibers (HP:0003200)2.01542596
104Abnormality of the tricuspid valve (HP:0001702)2.00164507
105Ankyloglossia (HP:0010296)2.00009594
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.98907877
107Distal lower limb amyotrophy (HP:0008944)1.97907666
108Respiratory difficulties (HP:0002880)1.95401158
109Abnormality of incisor morphology (HP:0011063)1.95342323
110Acute encephalopathy (HP:0006846)1.95070021
111Stridor (HP:0010307)1.95018156
112Distal lower limb muscle weakness (HP:0009053)1.94909007
113Deep palmar crease (HP:0006191)1.94314656
114Attenuation of retinal blood vessels (HP:0007843)1.94302329
115Abnormality of the Achilles tendon (HP:0005109)1.94152691
116Polycythemia (HP:0001901)1.93572784
117Decreased central vision (HP:0007663)1.92807303
118Type 2 muscle fiber atrophy (HP:0003554)1.92640724
119Focal motor seizures (HP:0011153)1.91032020
120Interstitial pulmonary disease (HP:0006530)1.90614421
121Spinal rigidity (HP:0003306)1.90343126
122Reticulocytopenia (HP:0001896)1.90286722
123Elbow flexion contracture (HP:0002987)1.89991776
124Congenital ichthyosiform erythroderma (HP:0007431)1.89156268
125Blue sclerae (HP:0000592)1.88764695
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.88485266
127Clubbing of toes (HP:0100760)1.88194424
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87822375
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.87822375
130Broad-based gait (HP:0002136)1.87347981
131Renal tubular dysfunction (HP:0000124)1.87203083
132Cheilitis (HP:0100825)1.86321923
133Diaphragmatic weakness (HP:0009113)1.86099215
134Spinal cord compression (HP:0002176)1.85630630
135Osteolytic defects of the hand bones (HP:0009699)1.85622671
136Osteolytic defects of the phalanges of the hand (HP:0009771)1.85622671
137Anomalous pulmonary venous return (HP:0010772)1.85412774
138Spastic diplegia (HP:0001264)1.85165187
139Exercise intolerance (HP:0003546)1.85028866
140Hepatic necrosis (HP:0002605)1.84355160
141Progressive external ophthalmoplegia (HP:0000590)1.84183076
142Cupped ear (HP:0000378)1.83064462
143Bladder diverticulum (HP:0000015)1.82666796
144Thin ribs (HP:0000883)1.82213338
145Increased serum lactate (HP:0002151)1.80674483
146Ankle contracture (HP:0006466)1.79766541
147Microvesicular hepatic steatosis (HP:0001414)1.78737027
148Hypokinesia (HP:0002375)1.77677733
149Hemorrhage of the eye (HP:0011885)1.77468373
150Spastic tetraparesis (HP:0001285)1.76079709
151Abnormality of oral frenula (HP:0000190)1.75942285
152Overfolded helix (HP:0000396)1.75913217
153Entropion (HP:0000621)1.75399582
154Aganglionic megacolon (HP:0002251)1.75326324
155Septo-optic dysplasia (HP:0100842)1.74802161
156Acute lymphatic leukemia (HP:0006721)1.74228686
157Adrenal hypoplasia (HP:0000835)1.74029096
158Aplasia/Hypoplasia of the lens (HP:0008063)1.72827430
159Nephronophthisis (HP:0000090)1.72423223
160Abnormality of the lacrimal duct (HP:0011481)1.72242072
161Aneurysm (HP:0002617)1.72133774
162Patent foramen ovale (HP:0001655)1.71628164
163Aplasia/Hypoplasia of the uvula (HP:0010293)1.71539461
164Fetal akinesia sequence (HP:0001989)1.71228436
165Back pain (HP:0003418)1.70947921
166Rough bone trabeculation (HP:0100670)1.70853835
167Hypercortisolism (HP:0001578)1.70770866
168Bulbar palsy (HP:0001283)1.69870710
169Congenital glaucoma (HP:0001087)1.69733813
170Molar tooth sign on MRI (HP:0002419)1.69490330
171Abnormality of midbrain morphology (HP:0002418)1.69490330
172Preaxial hand polydactyly (HP:0001177)1.69321712
173Optic nerve hypoplasia (HP:0000609)1.69189416
174Supranuclear gaze palsy (HP:0000605)1.69040660
175Retinal dysplasia (HP:0007973)1.68983307
176Recurrent otitis media (HP:0000403)1.68449560
177Abnormal respiratory motile cilium physiology (HP:0012261)1.67358164
178J-shaped sella turcica (HP:0002680)1.66846353
179Astigmatism (HP:0000483)1.66800061
180Meckel diverticulum (HP:0002245)1.66680811
181Male pseudohermaphroditism (HP:0000037)1.65923475
182Nonimmune hydrops fetalis (HP:0001790)1.64878635
183Poor coordination (HP:0002370)1.64770016
184Supernumerary spleens (HP:0009799)1.64755889
185Difficulty climbing stairs (HP:0003551)1.64754226
186Epileptic encephalopathy (HP:0200134)1.64255596
187Rhinitis (HP:0012384)1.64230523
188Hammertoe (HP:0001765)1.64168998
189Increased intramyocellular lipid droplets (HP:0012240)1.63726305
190Obstructive sleep apnea (HP:0002870)1.63403278
191Wormian bones (HP:0002645)1.62496627
192Pointed chin (HP:0000307)1.62191122
193Abnormality of cells of the erythroid lineage (HP:0012130)1.62138475
194Multiple lipomas (HP:0001012)1.61251387
195Aortic aneurysm (HP:0004942)1.60776185
196Spina bifida occulta (HP:0003298)1.59860143
197Long eyelashes (HP:0000527)1.59699126
198Venous abnormality (HP:0002624)1.54874564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.20189465
2CASK3.95910467
3SMG13.85550275
4ICK3.51685974
5EEF2K3.19399801
6STK163.07215904
7ERN12.96312392
8SIK12.61744505
9ZAK2.38302044
10EPHA22.29058349
11TNIK2.28737032
12IRAK42.27182903
13BMPR22.18261927
14PKN22.09083188
15BMPR1B2.08095265
16IRAK32.07997868
17NEK62.05924588
18CDK121.90513236
19MAP2K71.88026385
20ADRBK21.86577736
21SCYL21.73345048
22MAPKAPK51.73117862
23MAP3K101.67086605
24AKT31.66988241
25ARAF1.62176676
26MUSK1.58398515
27MAP3K121.57044630
28SRPK11.55735542
29VRK11.55082837
30STK391.53750060
31MAPK131.49999032
32MKNK21.47108725
33OXSR11.46651057
34PNCK1.46387299
35PAK41.42760005
36GRK71.42721541
37MAP3K141.42492637
38TXK1.40089264
39PLK21.39994765
40PRPF4B1.37540139
41TAOK21.36941898
42BLK1.35128894
43KSR21.33228701
44GRK51.32125029
45MST41.31963079
46TTN1.28644892
47EIF2AK21.23637485
48RIPK41.21610343
49CAMK1D1.20142674
50MAP3K131.18547813
51MKNK11.18137064
52FES1.17673347
53PLK41.15737369
54CDK81.13547434
55CDK31.12469666
56LRRK21.12400456
57NTRK31.09010001
58TESK11.07606490
59RPS6KB21.07536831
60YES11.05719576
61NME11.05012505
62MAP3K81.04543613
63CLK11.03508785
64MTOR1.01960877
65MARK11.01818916
66BUB11.01810087
67INSRR1.00511887
68TEC1.00009974
69TESK20.99127879
70PKN10.97351234
71MAP2K30.97313751
72TLK10.96885714
73GRK10.96765410
74IRAK10.95997684
75MARK20.95758460
76PRKD20.95237481
77PTK60.94294519
78PIK3CG0.93042986
79NEK90.90985661
80PBK0.90860973
81BCR0.90578975
82PDGFRA0.89436551
83NME20.89361966
84NTRK10.88726108
85PLK30.87459795
86SIK30.87130317
87IRAK20.86179141
88EPHB10.86161122
89PRKD30.84932959
90DYRK1A0.84272603
91EPHA40.84164722
92MAP2K20.83900445
93KIT0.83478482
94FGFR40.82793827
95RPS6KA20.82595518
96EIF2AK30.82320451
97CAMK2B0.81136633
98LMTK20.79561123
99PDPK10.78163340
100RPS6KL10.77838123
101RPS6KC10.77838123
102PRKCE0.76767037
103CAMK1G0.76341904
104VRK20.75227308
105BRAF0.75112197
106FGR0.74560506
107MST1R0.74500884
108TSSK60.73451360
109PIK3CA0.73212946
110PIM20.72760403
111MAPKAPK30.70117305
112CAMK2A0.69474927
113CAMK2D0.68705320
114CCNB10.68458412
115CDK70.68371550
116PTK20.66613155
117DYRK20.66501244
118IKBKB0.65767609
119LATS20.64833733
120AURKA0.64013341
121TAOK10.63671806
122RPS6KA50.62209421
123MAP3K10.62122166
124MAPK150.61154907
125NTRK20.60508535
126TIE10.60092692
127TNK20.59070024
128TBK10.59047118
129KSR10.58891103
130RIPK10.58656590
131PAK20.57819706
132CAMKK10.56548287
133CDK40.56494611
134LYN0.54453969
135ADRBK10.54255825
136CSNK1G30.53896034
137STK40.53494451
138RET0.53250718
139ERBB30.52968483
140RPS6KA60.52383011
141ILK0.52215409
142MAPK110.51584864
143MAP3K110.51506904
144WEE10.50935540
145CDC42BPA0.50798522
146BMX0.50551412
147UHMK10.49517131
148GRK60.48785210
149PRKCI0.48132173
150ROCK20.47665335
151MAP3K30.46562330
152SYK0.45674910
153MAP3K20.45131135
154TTK0.43785642
155MAP4K10.41737879
156BRD40.41671028
157MAP3K90.41251530
158AKT20.40627299
159PRKACA0.40146927
160PRKCG0.38945206
161PRKG10.38618234
162MET0.38073148
163RAF10.38020502
164MAP3K40.37399421
165KDR0.36438693
166CAMK2G0.36426123
167PTK2B0.36014885
168CDK190.35748747
169JAK30.35644019
170MAP3K60.35595089
171RPS6KA10.35088344
172ABL20.33799409
173HIPK20.33633193
174CSNK2A10.33309997
175ZAP700.33191168
176STK240.33151503
177CDK90.32772331
178TRPM70.32102130
179STK100.31532037
180PDK10.31135138

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.44278555
2Ribosome_Homo sapiens_hsa030102.89629186
3RNA polymerase_Homo sapiens_hsa030202.75471267
4Parkinsons disease_Homo sapiens_hsa050122.69280425
5Pentose phosphate pathway_Homo sapiens_hsa000302.68743044
6Other glycan degradation_Homo sapiens_hsa005112.67273870
7Protein export_Homo sapiens_hsa030602.56595901
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44054855
9Nicotine addiction_Homo sapiens_hsa050332.37810111
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26379912
11Alzheimers disease_Homo sapiens_hsa050102.21230249
12Chronic myeloid leukemia_Homo sapiens_hsa052202.21170311
13Acute myeloid leukemia_Homo sapiens_hsa052212.18007737
14Fanconi anemia pathway_Homo sapiens_hsa034602.15035285
15Endometrial cancer_Homo sapiens_hsa052132.08188102
16Huntingtons disease_Homo sapiens_hsa050162.07542580
17Biosynthesis of amino acids_Homo sapiens_hsa012302.06086548
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99343027
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.95587725
20Renal cell carcinoma_Homo sapiens_hsa052111.87376193
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85962013
22Proteasome_Homo sapiens_hsa030501.85089327
23Non-small cell lung cancer_Homo sapiens_hsa052231.83913272
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80897638
25Phototransduction_Homo sapiens_hsa047441.77976737
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77373257
27Pancreatic cancer_Homo sapiens_hsa052121.72641038
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71588929
29Homologous recombination_Homo sapiens_hsa034401.70335370
30Bladder cancer_Homo sapiens_hsa052191.69296873
31Collecting duct acid secretion_Homo sapiens_hsa049661.68939160
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67348625
33Thyroid cancer_Homo sapiens_hsa052161.62986770
34Notch signaling pathway_Homo sapiens_hsa043301.56448760
35Serotonergic synapse_Homo sapiens_hsa047261.55130016
36VEGF signaling pathway_Homo sapiens_hsa043701.52746722
37Sphingolipid metabolism_Homo sapiens_hsa006001.48771406
38Basal transcription factors_Homo sapiens_hsa030221.47394944
39Rheumatoid arthritis_Homo sapiens_hsa053231.46617753
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45332374
41Ether lipid metabolism_Homo sapiens_hsa005651.45278831
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44309985
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42781158
44Prion diseases_Homo sapiens_hsa050201.41263700
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41237660
46Sulfur relay system_Homo sapiens_hsa041221.40451425
47Autoimmune thyroid disease_Homo sapiens_hsa053201.39363171
48mTOR signaling pathway_Homo sapiens_hsa041501.38626195
49Pyrimidine metabolism_Homo sapiens_hsa002401.38624300
50Mismatch repair_Homo sapiens_hsa034301.38281935
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.38176905
52Taste transduction_Homo sapiens_hsa047421.36504427
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35170965
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34431955
55Colorectal cancer_Homo sapiens_hsa052101.33636810
56Non-homologous end-joining_Homo sapiens_hsa034501.32809787
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31717072
58Arachidonic acid metabolism_Homo sapiens_hsa005901.30948081
59Graft-versus-host disease_Homo sapiens_hsa053321.27768687
60Morphine addiction_Homo sapiens_hsa050321.27401804
61B cell receptor signaling pathway_Homo sapiens_hsa046621.25416962
62Purine metabolism_Homo sapiens_hsa002301.24901111
63Insulin signaling pathway_Homo sapiens_hsa049101.24781994
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.24723977
65Steroid biosynthesis_Homo sapiens_hsa001001.22345812
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.21733677
67Allograft rejection_Homo sapiens_hsa053301.21686926
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17997402
69Glioma_Homo sapiens_hsa052141.17475725
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17402443
71Carbon metabolism_Homo sapiens_hsa012001.14043926
72Fructose and mannose metabolism_Homo sapiens_hsa000511.13967052
73Glutamatergic synapse_Homo sapiens_hsa047241.13788729
74Apoptosis_Homo sapiens_hsa042101.13636836
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13187443
76DNA replication_Homo sapiens_hsa030301.13142051
77Spliceosome_Homo sapiens_hsa030401.12649773
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12304188
79ErbB signaling pathway_Homo sapiens_hsa040121.09697544
80Nucleotide excision repair_Homo sapiens_hsa034201.09418377
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07768842
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07694422
83Longevity regulating pathway - mammal_Homo sapiens_hsa042111.07397566
84Prostate cancer_Homo sapiens_hsa052151.02156409
85Viral carcinogenesis_Homo sapiens_hsa052031.00640369
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00340539
87Focal adhesion_Homo sapiens_hsa045100.99450846
88GABAergic synapse_Homo sapiens_hsa047270.99179745
89Shigellosis_Homo sapiens_hsa051310.97673470
90Vibrio cholerae infection_Homo sapiens_hsa051100.97333242
91AMPK signaling pathway_Homo sapiens_hsa041520.97183399
92Fatty acid elongation_Homo sapiens_hsa000620.95813125
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95570650
94MicroRNAs in cancer_Homo sapiens_hsa052060.94869866
95Prolactin signaling pathway_Homo sapiens_hsa049170.93543321
96Hepatitis B_Homo sapiens_hsa051610.91913783
97RNA degradation_Homo sapiens_hsa030180.90503671
98Small cell lung cancer_Homo sapiens_hsa052220.89707753
99Type I diabetes mellitus_Homo sapiens_hsa049400.89523168
100HTLV-I infection_Homo sapiens_hsa051660.87822628
101Estrogen signaling pathway_Homo sapiens_hsa049150.86757066
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86488808
103Cardiac muscle contraction_Homo sapiens_hsa042600.86432257
104Circadian entrainment_Homo sapiens_hsa047130.86277841
105Glutathione metabolism_Homo sapiens_hsa004800.85315469
106Phenylalanine metabolism_Homo sapiens_hsa003600.83546278
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82720136
108N-Glycan biosynthesis_Homo sapiens_hsa005100.81562765
109Inositol phosphate metabolism_Homo sapiens_hsa005620.80894499
110Proteoglycans in cancer_Homo sapiens_hsa052050.80597580
111HIF-1 signaling pathway_Homo sapiens_hsa040660.79486850
112Amphetamine addiction_Homo sapiens_hsa050310.79235788
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79135343
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79082784
115Hepatitis C_Homo sapiens_hsa051600.78750176
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78593410
117Choline metabolism in cancer_Homo sapiens_hsa052310.77990855
118Base excision repair_Homo sapiens_hsa034100.76819335
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76552878
120Galactose metabolism_Homo sapiens_hsa000520.75630402
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75118559
122Synaptic vesicle cycle_Homo sapiens_hsa047210.74942150
123Calcium signaling pathway_Homo sapiens_hsa040200.74334512
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73177495
125Linoleic acid metabolism_Homo sapiens_hsa005910.72929317
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.72347559
127Endocytosis_Homo sapiens_hsa041440.71809633
128Long-term depression_Homo sapiens_hsa047300.71746664
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71576934
130Asthma_Homo sapiens_hsa053100.71081014
131Phagosome_Homo sapiens_hsa041450.71046311
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.70845625
133Amoebiasis_Homo sapiens_hsa051460.70756079
134Hematopoietic cell lineage_Homo sapiens_hsa046400.69805519
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69772791
136Insulin resistance_Homo sapiens_hsa049310.68716648
137Lysosome_Homo sapiens_hsa041420.67152178
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65247763
139GnRH signaling pathway_Homo sapiens_hsa049120.64192234
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.63455763
141Cocaine addiction_Homo sapiens_hsa050300.62891760
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.60611049
143Primary immunodeficiency_Homo sapiens_hsa053400.60541105
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60356964
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59148742
146mRNA surveillance pathway_Homo sapiens_hsa030150.58382332
147Axon guidance_Homo sapiens_hsa043600.57367791
148ECM-receptor interaction_Homo sapiens_hsa045120.55926870
149Pathways in cancer_Homo sapiens_hsa052000.55315256
150Toxoplasmosis_Homo sapiens_hsa051450.53770754
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52965067
152Cholinergic synapse_Homo sapiens_hsa047250.51319277
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.51221306
154Salivary secretion_Homo sapiens_hsa049700.50029641
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49493941
156Cell cycle_Homo sapiens_hsa041100.49127200
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48762052
158Arginine biosynthesis_Homo sapiens_hsa002200.48729919
159Metabolic pathways_Homo sapiens_hsa011000.47692406
160Lysine degradation_Homo sapiens_hsa003100.47662341
161Salmonella infection_Homo sapiens_hsa051320.47116848
162African trypanosomiasis_Homo sapiens_hsa051430.47090903
163Sulfur metabolism_Homo sapiens_hsa009200.46840222
164Dopaminergic synapse_Homo sapiens_hsa047280.46021683
165Influenza A_Homo sapiens_hsa051640.44223566
166Melanoma_Homo sapiens_hsa052180.43408782
167TNF signaling pathway_Homo sapiens_hsa046680.43207582
168Olfactory transduction_Homo sapiens_hsa047400.42237153
169Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41820332
170Malaria_Homo sapiens_hsa051440.41024094
171Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39938581
172Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39236661
173Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38547032
174Intestinal immune network for IgA production_Homo sapiens_hsa046720.37469871
175Epstein-Barr virus infection_Homo sapiens_hsa051690.36926977
176Regulation of autophagy_Homo sapiens_hsa041400.35923477
177Ovarian steroidogenesis_Homo sapiens_hsa049130.35865237
178Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34739241
179Long-term potentiation_Homo sapiens_hsa047200.33445297
180Histidine metabolism_Homo sapiens_hsa003400.30906294
181Ras signaling pathway_Homo sapiens_hsa040140.30552125
182Vascular smooth muscle contraction_Homo sapiens_hsa042700.30479137
183Measles_Homo sapiens_hsa051620.30281071
184Alcoholism_Homo sapiens_hsa050340.29802796
185Vitamin B6 metabolism_Homo sapiens_hsa007500.27970826
186Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27892980
187Renin secretion_Homo sapiens_hsa049240.27641492
188Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26909885
189Pertussis_Homo sapiens_hsa051330.26485242

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