

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitotic metaphase plate congression (GO:0007080) | 4.92190996 |
| 2 | nucleobase biosynthetic process (GO:0046112) | 4.64295305 |
| 3 | DNA replication initiation (GO:0006270) | 4.55816914 |
| 4 | protein localization to kinetochore (GO:0034501) | 4.52057353 |
| 5 | purine nucleobase biosynthetic process (GO:0009113) | 4.50371376 |
| 6 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.43286478 |
| 7 | DNA replication checkpoint (GO:0000076) | 4.38320216 |
| 8 | metaphase plate congression (GO:0051310) | 4.30697563 |
| 9 | formation of translation preinitiation complex (GO:0001731) | 4.27493228 |
| 10 | DNA strand elongation (GO:0022616) | 4.21259814 |
| 11 | CENP-A containing nucleosome assembly (GO:0034080) | 4.20915773 |
| 12 | DNA unwinding involved in DNA replication (GO:0006268) | 4.19534475 |
| 13 | ribosome assembly (GO:0042255) | 4.19068265 |
| 14 | chromatin remodeling at centromere (GO:0031055) | 4.16614382 |
| 15 | mitotic nuclear envelope disassembly (GO:0007077) | 4.14370028 |
| 16 | nuclear pore organization (GO:0006999) | 4.13958356 |
| 17 | ribosomal small subunit biogenesis (GO:0042274) | 4.10729927 |
| 18 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.09537926 |
| 19 | IMP biosynthetic process (GO:0006188) | 4.08265007 |
| 20 | maturation of SSU-rRNA (GO:0030490) | 3.99311937 |
| 21 | ribosome biogenesis (GO:0042254) | 3.97932275 |
| 22 | establishment of integrated proviral latency (GO:0075713) | 3.96330014 |
| 23 | nuclear pore complex assembly (GO:0051292) | 3.94686872 |
| 24 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.91387396 |
| 25 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.91353477 |
| 26 | translational termination (GO:0006415) | 3.85753903 |
| 27 | protein localization to chromosome, centromeric region (GO:0071459) | 3.85044837 |
| 28 | DNA replication-independent nucleosome organization (GO:0034724) | 3.84631629 |
| 29 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.84631629 |
| 30 | viral transcription (GO:0019083) | 3.83246329 |
| 31 | nuclear envelope disassembly (GO:0051081) | 3.82913243 |
| 32 | membrane disassembly (GO:0030397) | 3.82913243 |
| 33 | telomere maintenance via recombination (GO:0000722) | 3.82214021 |
| 34 | kinetochore organization (GO:0051383) | 3.80929551 |
| 35 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.79995968 |
| 36 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.79995968 |
| 37 | establishment of chromosome localization (GO:0051303) | 3.79885309 |
| 38 | IMP metabolic process (GO:0046040) | 3.74514142 |
| 39 | regulation of spindle organization (GO:0090224) | 3.73057831 |
| 40 | mitotic recombination (GO:0006312) | 3.65538680 |
| 41 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.63981881 |
| 42 | ribosomal small subunit assembly (GO:0000028) | 3.62114175 |
| 43 | mitotic chromosome condensation (GO:0007076) | 3.61287736 |
| 44 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.60175807 |
| 45 | maturation of 5.8S rRNA (GO:0000460) | 3.58420709 |
| 46 | histone exchange (GO:0043486) | 3.58338094 |
| 47 | cotranslational protein targeting to membrane (GO:0006613) | 3.57611339 |
| 48 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.55585145 |
| 49 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.55180889 |
| 50 | protein targeting to ER (GO:0045047) | 3.54720326 |
| 51 | translation (GO:0006412) | 3.51055167 |
| 52 | kinetochore assembly (GO:0051382) | 3.49183751 |
| 53 | telomere maintenance via telomere lengthening (GO:0010833) | 3.47241935 |
| 54 | translational elongation (GO:0006414) | 3.44602973 |
| 55 | mitotic sister chromatid segregation (GO:0000070) | 3.41610461 |
| 56 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.41602809 |
| 57 | ribosomal large subunit biogenesis (GO:0042273) | 3.39730706 |
| 58 | negative regulation of ligase activity (GO:0051352) | 3.39713863 |
| 59 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.39713863 |
| 60 | cellular component biogenesis (GO:0044085) | 3.38525526 |
| 61 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.38273090 |
| 62 | rRNA processing (GO:0006364) | 3.37949208 |
| 63 | mitochondrial RNA metabolic process (GO:0000959) | 3.37773088 |
| 64 | rRNA methylation (GO:0031167) | 3.37519674 |
| 65 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.35154736 |
| 66 | termination of RNA polymerase III transcription (GO:0006386) | 3.35154736 |
| 67 | transcription from mitochondrial promoter (GO:0006390) | 3.33541748 |
| 68 | spindle checkpoint (GO:0031577) | 3.33274700 |
| 69 | DNA double-strand break processing (GO:0000729) | 3.32876782 |
| 70 | protein localization to endoplasmic reticulum (GO:0070972) | 3.31383335 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 3.30559145 |
| 72 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.29400024 |
| 73 | non-recombinational repair (GO:0000726) | 3.29400024 |
| 74 | oxidative phosphorylation (GO:0006119) | 3.28649648 |
| 75 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.28517221 |
| 76 | rRNA metabolic process (GO:0016072) | 3.28266075 |
| 77 | positive regulation of chromosome segregation (GO:0051984) | 3.25842117 |
| 78 | meiotic chromosome segregation (GO:0045132) | 3.25695333 |
| 79 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.25431007 |
| 80 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.25313015 |
| 81 | regulation of mitochondrial translation (GO:0070129) | 3.24621990 |
| 82 | negative regulation of chromosome segregation (GO:0051985) | 3.24195335 |
| 83 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.23855421 |
| 84 | negative regulation of sister chromatid segregation (GO:0033046) | 3.23855421 |
| 85 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.23855421 |
| 86 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.23855421 |
| 87 | pseudouridine synthesis (GO:0001522) | 3.21804749 |
| 88 | ATP synthesis coupled proton transport (GO:0015986) | 3.20728859 |
| 89 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.20728859 |
| 90 | spindle assembly checkpoint (GO:0071173) | 3.19781712 |
| 91 | DNA deamination (GO:0045006) | 3.19768087 |
| 92 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.19229327 |
| 93 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.18763700 |
| 94 | rRNA modification (GO:0000154) | 3.18653762 |
| 95 | mitotic spindle assembly checkpoint (GO:0007094) | 3.18528717 |
| 96 | mitotic spindle checkpoint (GO:0071174) | 3.18123847 |
| 97 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.16755661 |
| 98 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.15768540 |
| 99 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.15768540 |
| 100 | tRNA aminoacylation for protein translation (GO:0006418) | 3.13985019 |
| 101 | tRNA aminoacylation (GO:0043039) | 3.13663512 |
| 102 | amino acid activation (GO:0043038) | 3.13663512 |
| 103 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.12982508 |
| 104 | regulation of chromosome segregation (GO:0051983) | 3.12965721 |
| 105 | regulation of mitotic spindle organization (GO:0060236) | 3.12485034 |
| 106 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.12181974 |
| 107 | sister chromatid segregation (GO:0000819) | 3.08448282 |
| 108 | pore complex assembly (GO:0046931) | 3.07117748 |
| 109 | viral mRNA export from host cell nucleus (GO:0046784) | 3.05808004 |
| 110 | proteasome assembly (GO:0043248) | 3.05377749 |
| 111 | regulation of translational fidelity (GO:0006450) | 3.05195265 |
| 112 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.04268983 |
| 113 | DNA ligation (GO:0006266) | 3.04145928 |
| 114 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.03854746 |
| 115 | chromatin assembly or disassembly (GO:0006333) | 3.03710627 |
| 116 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.03644970 |
| 117 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.03644970 |
| 118 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.03644970 |
| 119 | mitotic sister chromatid cohesion (GO:0007064) | 3.03560504 |
| 120 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.02532833 |
| 121 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.02371062 |
| 122 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.01704431 |
| 123 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.01231903 |
| 124 | cell cycle G1/S phase transition (GO:0044843) | 3.01231903 |
| 125 | protein K6-linked ubiquitination (GO:0085020) | 3.00388411 |
| 126 | viral life cycle (GO:0019058) | 2.99593423 |
| 127 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.99543806 |
| 128 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.99543806 |
| 129 | regulation of centrosome cycle (GO:0046605) | 2.99275876 |
| 130 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.99017369 |
| 131 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.99017369 |
| 132 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.98795551 |
| 133 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.98795551 |
| 134 | regulation of sister chromatid segregation (GO:0033045) | 2.98795551 |
| 135 | negative regulation of RNA splicing (GO:0033119) | 2.98521249 |
| 136 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.98114023 |
| 137 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.97550504 |
| 138 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.97550504 |
| 139 | translational initiation (GO:0006413) | 2.97289411 |
| 140 | termination of RNA polymerase I transcription (GO:0006363) | 2.96516348 |
| 141 | DNA duplex unwinding (GO:0032508) | 2.96494404 |
| 142 | regulation of centriole replication (GO:0046599) | 2.96281777 |
| 143 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.96194198 |
| 144 | DNA geometric change (GO:0032392) | 2.95663384 |
| 145 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.95466923 |
| 146 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.95183249 |
| 147 | nuclear envelope organization (GO:0006998) | 2.95173375 |
| 148 | folic acid metabolic process (GO:0046655) | 2.93776963 |
| 149 | protein localization to chromosome (GO:0034502) | 2.91569449 |
| 150 | ATP-dependent chromatin remodeling (GO:0043044) | 2.91388409 |
| 151 | chromosome segregation (GO:0007059) | 2.89612565 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.86285457 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.53387577 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.95357813 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.90947895 |
| 5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.46006271 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.33536954 |
| 7 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.32168781 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.06749547 |
| 9 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.05898135 |
| 10 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.02156278 |
| 11 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.96750645 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.83899708 |
| 13 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.81995392 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.81844279 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.70003521 |
| 16 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.53335553 |
| 17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.52466618 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.42052199 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.34540313 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33900707 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.29625667 |
| 22 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.18381358 |
| 23 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.15954835 |
| 24 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.14688800 |
| 25 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.08408316 |
| 26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.04720308 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04490804 |
| 28 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.03681212 |
| 29 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.03310568 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.03210632 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98771678 |
| 32 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.93012221 |
| 33 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.91159547 |
| 34 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.83318811 |
| 35 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.82892719 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.81906784 |
| 37 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.80318776 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.79733554 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.78679809 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.72137981 |
| 41 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.71820396 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.70055839 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.68289301 |
| 44 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.66682659 |
| 45 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.62154098 |
| 46 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.59774389 |
| 47 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.57224153 |
| 48 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.53981234 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53478210 |
| 50 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.50769228 |
| 51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.45189042 |
| 52 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.44921514 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40259563 |
| 54 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.38407109 |
| 55 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.38207687 |
| 56 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.37617611 |
| 57 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.37597826 |
| 58 | MYC_22102868_ChIP-Seq_BL_Human | 1.36500737 |
| 59 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.35705566 |
| 60 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.32357139 |
| 61 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.29416284 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27029985 |
| 63 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.26839909 |
| 64 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25656354 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.22462626 |
| 66 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.20916247 |
| 67 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.20543613 |
| 68 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.18568521 |
| 69 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18529431 |
| 70 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.16430080 |
| 71 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15047483 |
| 72 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.14892152 |
| 73 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.13881736 |
| 74 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.13250326 |
| 75 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11659351 |
| 76 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.11070263 |
| 77 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.09105046 |
| 78 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.07939252 |
| 79 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.07264208 |
| 80 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.06048903 |
| 81 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.05192696 |
| 82 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01075676 |
| 83 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97736685 |
| 84 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.97302932 |
| 85 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.96840476 |
| 86 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.95515892 |
| 87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95128158 |
| 88 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89784800 |
| 89 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.89347104 |
| 90 | EWS_26573619_Chip-Seq_HEK293_Human | 0.86472828 |
| 91 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.85308380 |
| 92 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.84974053 |
| 93 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84504835 |
| 94 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.84412597 |
| 95 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81872738 |
| 96 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.80868915 |
| 97 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.80452866 |
| 98 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.78984092 |
| 99 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.78893662 |
| 100 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.78242849 |
| 101 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77811321 |
| 102 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.77403220 |
| 103 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.77215625 |
| 104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.75101074 |
| 105 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.74376402 |
| 106 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.73018501 |
| 107 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.71236191 |
| 108 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.70833079 |
| 109 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.69913396 |
| 110 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.69495115 |
| 111 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.67199226 |
| 112 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.66539626 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.78300442 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.76200408 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.62048948 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.34944050 |
| 5 | MP0003077_abnormal_cell_cycle | 4.16312149 |
| 6 | MP0008057_abnormal_DNA_replication | 3.92209139 |
| 7 | MP0008058_abnormal_DNA_repair | 3.50082791 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.16469232 |
| 9 | MP0003123_paternal_imprinting | 2.84666196 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.80385431 |
| 11 | MP0008877_abnormal_DNA_methylation | 2.69063214 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.55429169 |
| 13 | MP0001730_embryonic_growth_arrest | 2.48678431 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.33347751 |
| 15 | MP0003718_maternal_effect | 2.29710319 |
| 16 | MP0010352_gastrointestinal_tract_polyps | 2.09179519 |
| 17 | MP0003786_premature_aging | 2.06770331 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 1.90976177 |
| 19 | MP0010307_abnormal_tumor_latency | 1.88757725 |
| 20 | MP0005380_embryogenesis_phenotype | 1.85597644 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 1.85597644 |
| 22 | MP0006035_abnormal_mitochondrial_morpho | 1.83031888 |
| 23 | MP0001697_abnormal_embryo_size | 1.82290048 |
| 24 | MP0003984_embryonic_growth_retardation | 1.65162675 |
| 25 | MP0003121_genomic_imprinting | 1.62776900 |
| 26 | MP0002080_prenatal_lethality | 1.60596369 |
| 27 | MP0002088_abnormal_embryonic_growth/wei | 1.59979936 |
| 28 | MP0002085_abnormal_embryonic_tissue | 1.59829924 |
| 29 | MP0000490_abnormal_crypts_of | 1.57118683 |
| 30 | MP0009379_abnormal_foot_pigmentation | 1.57108201 |
| 31 | MP0002084_abnormal_developmental_patter | 1.53053734 |
| 32 | MP0004808_abnormal_hematopoietic_stem | 1.46117137 |
| 33 | MP0002086_abnormal_extraembryonic_tissu | 1.42003967 |
| 34 | MP0002019_abnormal_tumor_incidence | 1.41183842 |
| 35 | MP0000313_abnormal_cell_death | 1.40352700 |
| 36 | MP0002210_abnormal_sex_determination | 1.39598548 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.38139205 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37453934 |
| 39 | MP0003806_abnormal_nucleotide_metabolis | 1.33052597 |
| 40 | MP0002006_tumorigenesis | 1.32881108 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.30794466 |
| 42 | MP0008995_early_reproductive_senescence | 1.28427563 |
| 43 | MP0003315_abnormal_perineum_morphology | 1.26474213 |
| 44 | MP0002166_altered_tumor_susceptibility | 1.24893136 |
| 45 | MP0010030_abnormal_orbit_morphology | 1.24109636 |
| 46 | MP0003890_abnormal_embryonic-extraembry | 1.22999520 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.22952278 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.20665904 |
| 49 | MP0003763_abnormal_thymus_physiology | 1.18752696 |
| 50 | MP0001145_abnormal_male_reproductive | 1.17928044 |
| 51 | MP0001881_abnormal_mammary_gland | 1.16578112 |
| 52 | MP0001293_anophthalmia | 1.16418308 |
| 53 | MP0001119_abnormal_female_reproductive | 1.14499561 |
| 54 | MP0000653_abnormal_sex_gland | 1.13003767 |
| 55 | MP0001929_abnormal_gametogenesis | 1.11261509 |
| 56 | MP0000372_irregular_coat_pigmentation | 1.03364720 |
| 57 | MP0001661_extended_life_span | 1.03206902 |
| 58 | MP0005408_hypopigmentation | 0.98708201 |
| 59 | MP0005397_hematopoietic_system_phenotyp | 0.97557485 |
| 60 | MP0001545_abnormal_hematopoietic_system | 0.97557485 |
| 61 | MP0000703_abnormal_thymus_morphology | 0.97071426 |
| 62 | MP0003937_abnormal_limbs/digits/tail_de | 0.95978803 |
| 63 | MP0002009_preneoplasia | 0.94171502 |
| 64 | MP0002160_abnormal_reproductive_system | 0.93313060 |
| 65 | MP0009672_abnormal_birth_weight | 0.92555943 |
| 66 | MP0003186_abnormal_redox_activity | 0.92397564 |
| 67 | MP0001764_abnormal_homeostasis | 0.90430170 |
| 68 | MP0009697_abnormal_copulation | 0.90297996 |
| 69 | MP0003221_abnormal_cardiomyocyte_apopto | 0.87706913 |
| 70 | MP0006072_abnormal_retinal_apoptosis | 0.87596813 |
| 71 | MP0005076_abnormal_cell_differentiation | 0.86885693 |
| 72 | MP0005389_reproductive_system_phenotype | 0.86755169 |
| 73 | MP0009053_abnormal_anal_canal | 0.85841567 |
| 74 | MP0002398_abnormal_bone_marrow | 0.85619333 |
| 75 | MP0004147_increased_porphyrin_level | 0.83463090 |
| 76 | MP0002722_abnormal_immune_system | 0.82178832 |
| 77 | MP0003941_abnormal_skin_development | 0.81428907 |
| 78 | MP0003119_abnormal_digestive_system | 0.81023906 |
| 79 | MP0002111_abnormal_tail_morphology | 0.81014465 |
| 80 | MP0000689_abnormal_spleen_morphology | 0.80531368 |
| 81 | MP0005384_cellular_phenotype | 0.79710257 |
| 82 | MP0005501_abnormal_skin_physiology | 0.77951095 |
| 83 | MP0000358_abnormal_cell_content/ | 0.77855473 |
| 84 | MP0001915_intracranial_hemorrhage | 0.77545565 |
| 85 | MP0000537_abnormal_urethra_morphology | 0.75657678 |
| 86 | MP0001873_stomach_inflammation | 0.75462821 |
| 87 | MP0006054_spinal_hemorrhage | 0.75192042 |
| 88 | MP0005023_abnormal_wound_healing | 0.74440482 |
| 89 | MP0005395_other_phenotype | 0.74019218 |
| 90 | MP0005621_abnormal_cell_physiology | 0.73929638 |
| 91 | MP0004782_abnormal_surfactant_physiolog | 0.72755958 |
| 92 | MP0003699_abnormal_female_reproductive | 0.72697542 |
| 93 | MP0002938_white_spotting | 0.71376642 |
| 94 | MP0008875_abnormal_xenobiotic_pharmacok | 0.70954427 |
| 95 | MP0001286_abnormal_eye_development | 0.69866848 |
| 96 | MP0001919_abnormal_reproductive_system | 0.69371569 |
| 97 | MP0004264_abnormal_extraembryonic_tissu | 0.67171916 |
| 98 | MP0002102_abnormal_ear_morphology | 0.66253809 |
| 99 | MP0009703_decreased_birth_body | 0.65549598 |
| 100 | MP0000858_altered_metastatic_potential | 0.64850783 |
| 101 | MP0002796_impaired_skin_barrier | 0.64743013 |
| 102 | MP0002132_abnormal_respiratory_system | 0.64641428 |
| 103 | MP0002429_abnormal_blood_cell | 0.63455938 |
| 104 | MP0003950_abnormal_plasma_membrane | 0.63379888 |
| 105 | MP0002653_abnormal_ependyma_morphology | 0.61867129 |
| 106 | MP0001835_abnormal_antigen_presentation | 0.61391802 |
| 107 | MP0000428_abnormal_craniofacial_morphol | 0.60968708 |
| 108 | MP0002877_abnormal_melanocyte_morpholog | 0.60898852 |
| 109 | MP0003787_abnormal_imprinting | 0.60064711 |
| 110 | MP0000432_abnormal_head_morphology | 0.58461125 |
| 111 | MP0004233_abnormal_muscle_weight | 0.58111653 |
| 112 | MP0005330_cardiomyopathy | 0.57471695 |
| 113 | MP0008873_increased_physiological_sensi | 0.57227889 |
| 114 | MP0002092_abnormal_eye_morphology | 0.56175370 |
| 115 | MP0000477_abnormal_intestine_morphology | 0.56081268 |
| 116 | MP0001727_abnormal_embryo_implantation | 0.55573494 |
| 117 | MP0003936_abnormal_reproductive_system | 0.54720725 |
| 118 | MP0003943_abnormal_hepatobiliary_system | 0.54159400 |
| 119 | MP0004185_abnormal_adipocyte_glucose | 0.53824569 |
| 120 | MP0004133_heterotaxia | 0.53483142 |
| 121 | MP0003698_abnormal_male_reproductive | 0.51600515 |
| 122 | MP0002161_abnormal_fertility/fecundity | 0.50790544 |
| 123 | MP0000598_abnormal_liver_morphology | 0.50475581 |
| 124 | MP0000627_abnormal_mammary_gland | 0.50431253 |
| 125 | MP0001849_ear_inflammation | 0.49998096 |
| 126 | MP0002114_abnormal_axial_skeleton | 0.48721442 |
| 127 | MP0003755_abnormal_palate_morphology | 0.48695489 |
| 128 | MP0001853_heart_inflammation | 0.47736742 |
| 129 | MP0000716_abnormal_immune_system | 0.47366191 |
| 130 | MP0005266_abnormal_metabolism | 0.46774014 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.69903082 |
| 2 | Breast hypoplasia (HP:0003187) | 4.15824248 |
| 3 | Chromsome breakage (HP:0040012) | 3.97338063 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 3.74269474 |
| 5 | Patellar aplasia (HP:0006443) | 3.67177594 |
| 6 | Oral leukoplakia (HP:0002745) | 3.58917111 |
| 7 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.57986366 |
| 8 | Microvesicular hepatic steatosis (HP:0001414) | 3.53866056 |
| 9 | Colon cancer (HP:0003003) | 3.53464098 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 3.51137074 |
| 11 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.43830721 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.43434605 |
| 13 | Increased CSF lactate (HP:0002490) | 3.43349441 |
| 14 | Degeneration of anterior horn cells (HP:0002398) | 3.36493872 |
| 15 | Abnormality of the anterior horn cell (HP:0006802) | 3.36493872 |
| 16 | Medulloblastoma (HP:0002885) | 3.32178676 |
| 17 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.29197675 |
| 18 | Acute encephalopathy (HP:0006846) | 3.28951762 |
| 19 | Carpal bone hypoplasia (HP:0001498) | 3.28634923 |
| 20 | Abnormality of chromosome stability (HP:0003220) | 3.26003934 |
| 21 | Selective tooth agenesis (HP:0001592) | 3.25267810 |
| 22 | Reticulocytopenia (HP:0001896) | 3.24894980 |
| 23 | Mitochondrial inheritance (HP:0001427) | 3.17383446 |
| 24 | Aplastic anemia (HP:0001915) | 3.15598050 |
| 25 | Increased serum lactate (HP:0002151) | 3.14744053 |
| 26 | Type I transferrin isoform profile (HP:0003642) | 3.14120345 |
| 27 | Abnormality of the preputium (HP:0100587) | 3.13850958 |
| 28 | Meckel diverticulum (HP:0002245) | 3.07712381 |
| 29 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.06688654 |
| 30 | Abnormality of methionine metabolism (HP:0010901) | 3.04951767 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.98295329 |
| 32 | Abnormal number of erythroid precursors (HP:0012131) | 2.95388904 |
| 33 | Hepatocellular necrosis (HP:0001404) | 2.94419211 |
| 34 | Abnormality of the ileum (HP:0001549) | 2.88951301 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.86899114 |
| 36 | Cerebral hypomyelination (HP:0006808) | 2.86176888 |
| 37 | Progressive macrocephaly (HP:0004481) | 2.85475490 |
| 38 | Hepatic necrosis (HP:0002605) | 2.84289966 |
| 39 | Agnosia (HP:0010524) | 2.81477672 |
| 40 | Increased serum pyruvate (HP:0003542) | 2.79125903 |
| 41 | Abnormality of glycolysis (HP:0004366) | 2.77758707 |
| 42 | Ependymoma (HP:0002888) | 2.77142511 |
| 43 | Impulsivity (HP:0100710) | 2.76215061 |
| 44 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.75106379 |
| 45 | Cerebral edema (HP:0002181) | 2.73624489 |
| 46 | Myelodysplasia (HP:0002863) | 2.73371972 |
| 47 | Absent radius (HP:0003974) | 2.66050910 |
| 48 | Progressive muscle weakness (HP:0003323) | 2.65706387 |
| 49 | Rhabdomyosarcoma (HP:0002859) | 2.65658183 |
| 50 | Duodenal stenosis (HP:0100867) | 2.63545501 |
| 51 | Small intestinal stenosis (HP:0012848) | 2.63545501 |
| 52 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.62265588 |
| 53 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.62265588 |
| 54 | Absent thumb (HP:0009777) | 2.61062028 |
| 55 | Increased intramyocellular lipid droplets (HP:0012240) | 2.55441123 |
| 56 | Lactic acidosis (HP:0003128) | 2.54276711 |
| 57 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.52739241 |
| 58 | Ectopic kidney (HP:0000086) | 2.52044684 |
| 59 | Renal Fanconi syndrome (HP:0001994) | 2.51233999 |
| 60 | Abnormal lung lobation (HP:0002101) | 2.50478607 |
| 61 | Reduced antithrombin III activity (HP:0001976) | 2.47311513 |
| 62 | Absent forearm bone (HP:0003953) | 2.46912943 |
| 63 | Aplasia involving forearm bones (HP:0009822) | 2.46912943 |
| 64 | Premature graying of hair (HP:0002216) | 2.44805003 |
| 65 | Premature ovarian failure (HP:0008209) | 2.44026214 |
| 66 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.43946982 |
| 67 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.43946982 |
| 68 | Abnormal protein glycosylation (HP:0012346) | 2.43946982 |
| 69 | Abnormal glycosylation (HP:0012345) | 2.43946982 |
| 70 | Microretrognathia (HP:0000308) | 2.43583648 |
| 71 | Respiratory difficulties (HP:0002880) | 2.41672778 |
| 72 | Hyperalaninemia (HP:0003348) | 2.41631037 |
| 73 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.41631037 |
| 74 | Abnormality of alanine metabolism (HP:0010916) | 2.41631037 |
| 75 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.39536619 |
| 76 | Supernumerary spleens (HP:0009799) | 2.39168897 |
| 77 | Sloping forehead (HP:0000340) | 2.39049862 |
| 78 | Neoplasm of the pancreas (HP:0002894) | 2.37718363 |
| 79 | Bone marrow hypocellularity (HP:0005528) | 2.32594708 |
| 80 | Exercise intolerance (HP:0003546) | 2.32023551 |
| 81 | 3-Methylglutaconic aciduria (HP:0003535) | 2.29359749 |
| 82 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.29207551 |
| 83 | Secondary amenorrhea (HP:0000869) | 2.28693313 |
| 84 | Pancytopenia (HP:0001876) | 2.27469244 |
| 85 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.27327406 |
| 86 | Atresia of the external auditory canal (HP:0000413) | 2.26207747 |
| 87 | 11 pairs of ribs (HP:0000878) | 2.25661005 |
| 88 | Horseshoe kidney (HP:0000085) | 2.22817982 |
| 89 | Basal cell carcinoma (HP:0002671) | 2.19973486 |
| 90 | Abnormality of the duodenum (HP:0002246) | 2.19578486 |
| 91 | Deviation of the thumb (HP:0009603) | 2.18819658 |
| 92 | Trismus (HP:0000211) | 2.18042838 |
| 93 | Megaloblastic anemia (HP:0001889) | 2.17058990 |
| 94 | Progressive external ophthalmoplegia (HP:0000590) | 2.15801307 |
| 95 | Proximal placement of thumb (HP:0009623) | 2.15702899 |
| 96 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.14801782 |
| 97 | IgM deficiency (HP:0002850) | 2.14670657 |
| 98 | Facial hemangioma (HP:0000329) | 2.13637078 |
| 99 | Abnormality of serum amino acid levels (HP:0003112) | 2.13227153 |
| 100 | Squamous cell carcinoma (HP:0002860) | 2.12997528 |
| 101 | Abnormal number of incisors (HP:0011064) | 2.12605555 |
| 102 | Multiple enchondromatosis (HP:0005701) | 2.12259090 |
| 103 | Irregular epiphyses (HP:0010582) | 2.09563995 |
| 104 | Short thumb (HP:0009778) | 2.08411750 |
| 105 | Abnormal trabecular bone morphology (HP:0100671) | 2.08216380 |
| 106 | Cellular immunodeficiency (HP:0005374) | 2.06314400 |
| 107 | Increased muscle lipid content (HP:0009058) | 2.05820193 |
| 108 | Macrocytic anemia (HP:0001972) | 2.05153828 |
| 109 | Methylmalonic acidemia (HP:0002912) | 2.04704135 |
| 110 | Glossoptosis (HP:0000162) | 2.04690371 |
| 111 | Triphalangeal thumb (HP:0001199) | 2.04240057 |
| 112 | Tracheoesophageal fistula (HP:0002575) | 2.03400566 |
| 113 | Acute myeloid leukemia (HP:0004808) | 2.02321073 |
| 114 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.02067941 |
| 115 | Exertional dyspnea (HP:0002875) | 2.01944002 |
| 116 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.96237812 |
| 117 | Respiratory failure (HP:0002878) | 1.95100415 |
| 118 | Volvulus (HP:0002580) | 1.95086591 |
| 119 | Abnormality of homocysteine metabolism (HP:0010919) | 1.94119189 |
| 120 | Homocystinuria (HP:0002156) | 1.94119189 |
| 121 | Increased nuchal translucency (HP:0010880) | 1.93752489 |
| 122 | Cleft eyelid (HP:0000625) | 1.93623121 |
| 123 | Amaurosis fugax (HP:0100576) | 1.93317659 |
| 124 | Slender long bone (HP:0003100) | 1.93262282 |
| 125 | Abnormality of the pons (HP:0007361) | 1.92549240 |
| 126 | Testicular atrophy (HP:0000029) | 1.91247343 |
| 127 | Abnormality of placental membranes (HP:0011409) | 1.90992630 |
| 128 | Amniotic constriction ring (HP:0009775) | 1.90992630 |
| 129 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.90680192 |
| 130 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.90415924 |
| 131 | Neoplasm of the colon (HP:0100273) | 1.87901608 |
| 132 | Abnormality of the carotid arteries (HP:0005344) | 1.87834090 |
| 133 | Abnormal spermatogenesis (HP:0008669) | 1.87569580 |
| 134 | Hypoplasia of the pons (HP:0012110) | 1.86102550 |
| 135 | Leukodystrophy (HP:0002415) | 1.85707188 |
| 136 | Embryonal renal neoplasm (HP:0011794) | 1.85587541 |
| 137 | Thrombocytosis (HP:0001894) | 1.84844183 |
| 138 | Pallor (HP:0000980) | 1.82880962 |
| 139 | Lethargy (HP:0001254) | 1.81698964 |
| 140 | Hypoplasia of the radius (HP:0002984) | 1.81421186 |
| 141 | Cafe-au-lait spot (HP:0000957) | 1.81394782 |
| 142 | Stenosis of the external auditory canal (HP:0000402) | 1.80837249 |
| 143 | Generalized aminoaciduria (HP:0002909) | 1.80391645 |
| 144 | Sparse eyelashes (HP:0000653) | 1.80323534 |
| 145 | CNS hypomyelination (HP:0003429) | 1.79914188 |
| 146 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.79794229 |
| 147 | Methylmalonic aciduria (HP:0012120) | 1.78545174 |
| 148 | Neoplasm of striated muscle (HP:0009728) | 1.78225964 |
| 149 | Facial cleft (HP:0002006) | 1.77868843 |
| 150 | Lymphoma (HP:0002665) | 1.77708514 |
| 151 | Neoplasm of the oral cavity (HP:0100649) | 1.77045172 |
| 152 | Abnormality of the calcaneus (HP:0008364) | 1.76982459 |
| 153 | Entropion (HP:0000621) | 1.76944921 |
| 154 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.76346947 |
| 155 | Optic nerve coloboma (HP:0000588) | 1.76272199 |
| 156 | Missing ribs (HP:0000921) | 1.76080790 |
| 157 | Capillary hemangiomas (HP:0005306) | 1.73312121 |
| 158 | Prominent nose (HP:0000448) | 1.70776674 |
| 159 | Muscle fiber atrophy (HP:0100295) | 1.70670793 |
| 160 | Clubbing of toes (HP:0100760) | 1.69824175 |
| 161 | Spinal muscular atrophy (HP:0007269) | 1.69327637 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.37476242 |
| 2 | CDC7 | 4.34803559 |
| 3 | WEE1 | 4.20302010 |
| 4 | EIF2AK1 | 3.55983401 |
| 5 | VRK2 | 3.42734440 |
| 6 | SRPK1 | 2.82074950 |
| 7 | ACVR1B | 2.70959839 |
| 8 | PLK4 | 2.62618138 |
| 9 | TTK | 2.59498941 |
| 10 | NEK2 | 2.52215473 |
| 11 | TSSK6 | 2.49312842 |
| 12 | BRSK2 | 2.32412828 |
| 13 | NEK1 | 2.24949796 |
| 14 | MKNK1 | 2.18428085 |
| 15 | EIF2AK3 | 2.17001880 |
| 16 | PLK1 | 2.13582785 |
| 17 | PLK3 | 1.94185240 |
| 18 | NME2 | 1.87391345 |
| 19 | MKNK2 | 1.80895590 |
| 20 | TAF1 | 1.80376681 |
| 21 | AURKB | 1.79043964 |
| 22 | STK16 | 1.71290396 |
| 23 | ATR | 1.69646724 |
| 24 | VRK1 | 1.69115120 |
| 25 | PASK | 1.65201061 |
| 26 | CDK7 | 1.63787682 |
| 27 | CHEK2 | 1.57931459 |
| 28 | RPS6KB2 | 1.56585041 |
| 29 | RPS6KA4 | 1.48371180 |
| 30 | STK10 | 1.36847466 |
| 31 | BRSK1 | 1.34580430 |
| 32 | CHEK1 | 1.31387436 |
| 33 | TESK2 | 1.29640913 |
| 34 | MAP3K8 | 1.29513109 |
| 35 | DYRK3 | 1.28237942 |
| 36 | AURKA | 1.26586010 |
| 37 | CDK4 | 1.22878686 |
| 38 | TGFBR1 | 1.22393065 |
| 39 | CDK12 | 1.19282336 |
| 40 | EPHA2 | 1.18341030 |
| 41 | EEF2K | 1.15970699 |
| 42 | CCNB1 | 1.14217781 |
| 43 | BMPR1B | 1.13916875 |
| 44 | TRIM28 | 1.11003124 |
| 45 | STK38L | 1.09206337 |
| 46 | PDK2 | 1.03775675 |
| 47 | TLK1 | 0.97787808 |
| 48 | CDK8 | 0.97126797 |
| 49 | ATM | 0.96264342 |
| 50 | ZAK | 0.95063772 |
| 51 | MELK | 0.93269787 |
| 52 | SMG1 | 0.89739277 |
| 53 | STK4 | 0.89473918 |
| 54 | BCKDK | 0.87533582 |
| 55 | CDK2 | 0.86983725 |
| 56 | SCYL2 | 0.83807681 |
| 57 | BRAF | 0.83554176 |
| 58 | PIM1 | 0.80726098 |
| 59 | STK3 | 0.80272588 |
| 60 | PIM2 | 0.80105808 |
| 61 | PAK4 | 0.79301486 |
| 62 | PBK | 0.78973598 |
| 63 | MAPKAPK5 | 0.77873056 |
| 64 | LATS2 | 0.74919566 |
| 65 | EIF2AK2 | 0.71719374 |
| 66 | CSNK2A2 | 0.71594773 |
| 67 | MAP4K2 | 0.69611502 |
| 68 | CSNK2A1 | 0.68504661 |
| 69 | CDK1 | 0.67740491 |
| 70 | LATS1 | 0.65170239 |
| 71 | ALK | 0.64334284 |
| 72 | FLT3 | 0.63624012 |
| 73 | CDK6 | 0.61829085 |
| 74 | ERBB3 | 0.61647177 |
| 75 | STK24 | 0.60617763 |
| 76 | PAK1 | 0.58750856 |
| 77 | DAPK1 | 0.56799907 |
| 78 | MAP3K12 | 0.56385263 |
| 79 | BRD4 | 0.55413749 |
| 80 | MAP4K1 | 0.52830425 |
| 81 | MAPKAPK3 | 0.52505554 |
| 82 | PRKCI | 0.49140080 |
| 83 | NEK9 | 0.46922898 |
| 84 | WNK4 | 0.44895410 |
| 85 | TEC | 0.43556875 |
| 86 | RAF1 | 0.42353838 |
| 87 | KDR | 0.42089747 |
| 88 | MAP3K6 | 0.41584714 |
| 89 | LRRK2 | 0.41089714 |
| 90 | PNCK | 0.40427661 |
| 91 | MAP3K11 | 0.40314685 |
| 92 | CSNK1E | 0.40301541 |
| 93 | MAP3K14 | 0.40263844 |
| 94 | MST4 | 0.40066760 |
| 95 | NME1 | 0.38461984 |
| 96 | CDK9 | 0.38135087 |
| 97 | PKN2 | 0.38092202 |
| 98 | DYRK2 | 0.37937469 |
| 99 | RPS6KA5 | 0.37661797 |
| 100 | TAOK2 | 0.37521100 |
| 101 | MAP3K5 | 0.36879329 |
| 102 | NLK | 0.36571821 |
| 103 | PAK2 | 0.34484176 |
| 104 | MAP2K3 | 0.34039907 |
| 105 | PDK3 | 0.32530842 |
| 106 | PDK4 | 0.32530842 |
| 107 | FGFR1 | 0.31499681 |
| 108 | PRKDC | 0.30690423 |
| 109 | STK39 | 0.29568522 |
| 110 | TAOK3 | 0.29155277 |
| 111 | AKT2 | 0.29016982 |
| 112 | MST1R | 0.28691344 |
| 113 | CSNK1G1 | 0.28677129 |
| 114 | MTOR | 0.27709620 |
| 115 | ERBB4 | 0.27404210 |
| 116 | NUAK1 | 0.25802654 |
| 117 | TESK1 | 0.24718655 |
| 118 | MAPK14 | 0.24662107 |
| 119 | CLK1 | 0.24280226 |
| 120 | TXK | 0.24224545 |
| 121 | RPS6KB1 | 0.23851576 |
| 122 | BTK | 0.23253607 |
| 123 | NEK6 | 0.21376552 |
| 124 | CSNK1G3 | 0.19503109 |
| 125 | ILK | 0.18750314 |
| 126 | CDK3 | 0.18041177 |
| 127 | BMPR2 | 0.17951182 |
| 128 | CDK19 | 0.16360445 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.72511698 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.19533798 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.13023377 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.48110321 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.43623426 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.30297354 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.27171472 |
| 8 | Cell cycle_Homo sapiens_hsa04110 | 3.03722537 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.96214899 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.93562090 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.91630785 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.91341265 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.61249987 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.51014785 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.47841845 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.34459068 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 2.30973933 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.28673018 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.25593293 |
| 20 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.91518232 |
| 21 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.85374385 |
| 22 | Parkinsons disease_Homo sapiens_hsa05012 | 1.81858806 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.72395836 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.43013064 |
| 25 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.27038176 |
| 26 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.23492979 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.17042854 |
| 28 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.13844809 |
| 29 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.09596802 |
| 30 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.06384136 |
| 31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.05924343 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.00712440 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.98499390 |
| 34 | Alzheimers disease_Homo sapiens_hsa05010 | 0.95144701 |
| 35 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.91573615 |
| 36 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.90387150 |
| 37 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.89430350 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.89321058 |
| 39 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.85730091 |
| 40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.85360654 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83174232 |
| 42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.81399217 |
| 43 | Thyroid cancer_Homo sapiens_hsa05216 | 0.80191778 |
| 44 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.77482761 |
| 45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.77024055 |
| 46 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.76653643 |
| 47 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.74872071 |
| 48 | Protein export_Homo sapiens_hsa03060 | 0.74161187 |
| 49 | HTLV-I infection_Homo sapiens_hsa05166 | 0.72697700 |
| 50 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.71689426 |
| 51 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.70110024 |
| 52 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.69221295 |
| 53 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.66732457 |
| 54 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.65076065 |
| 55 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.65061420 |
| 56 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.64008508 |
| 57 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61482204 |
| 58 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.54332438 |
| 59 | Legionellosis_Homo sapiens_hsa05134 | 0.52035336 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44643935 |
| 61 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.44263125 |
| 62 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.42705601 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42647965 |
| 64 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42473517 |
| 65 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.41903134 |
| 66 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.41621540 |
| 67 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.41358333 |
| 68 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.40922053 |
| 69 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40675256 |
| 70 | Sulfur relay system_Homo sapiens_hsa04122 | 0.40385596 |
| 71 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.40322594 |
| 72 | Colorectal cancer_Homo sapiens_hsa05210 | 0.38221578 |
| 73 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.37282612 |
| 74 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37218677 |
| 75 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36960401 |
| 76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.36857053 |
| 77 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.36845562 |
| 78 | Measles_Homo sapiens_hsa05162 | 0.35329676 |
| 79 | Huntingtons disease_Homo sapiens_hsa05016 | 0.33579124 |
| 80 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.33025429 |
| 81 | Lysine degradation_Homo sapiens_hsa00310 | 0.32847330 |
| 82 | Apoptosis_Homo sapiens_hsa04210 | 0.31889857 |
| 83 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.31841427 |
| 84 | Hepatitis B_Homo sapiens_hsa05161 | 0.31674115 |
| 85 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.31346974 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31003993 |
| 87 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.30081790 |
| 88 | Peroxisome_Homo sapiens_hsa04146 | 0.28654552 |
| 89 | Shigellosis_Homo sapiens_hsa05131 | 0.28496046 |
| 90 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.27065811 |
| 91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.26586612 |
| 92 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.26109914 |
| 93 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.24637719 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24383705 |
| 95 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.23421276 |
| 96 | Adherens junction_Homo sapiens_hsa04520 | 0.22311785 |
| 97 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.21032534 |
| 98 | Influenza A_Homo sapiens_hsa05164 | 0.20792126 |
| 99 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.20780013 |
| 100 | Pathways in cancer_Homo sapiens_hsa05200 | 0.20180010 |
| 101 | Alcoholism_Homo sapiens_hsa05034 | 0.17862044 |
| 102 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.17683487 |
| 103 | Metabolic pathways_Homo sapiens_hsa01100 | 0.17601631 |
| 104 | Bladder cancer_Homo sapiens_hsa05219 | 0.17364433 |
| 105 | Viral myocarditis_Homo sapiens_hsa05416 | 0.17169239 |
| 106 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.17069753 |
| 107 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.16428810 |
| 108 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.16396679 |
| 109 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.15696591 |
| 110 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.15255477 |
| 111 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.15097402 |
| 112 | Galactose metabolism_Homo sapiens_hsa00052 | 0.14929010 |
| 113 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.14927975 |
| 114 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.14923760 |
| 115 | Allograft rejection_Homo sapiens_hsa05330 | 0.14708018 |
| 116 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.14355311 |
| 117 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.14139104 |
| 118 | Prostate cancer_Homo sapiens_hsa05215 | 0.13394146 |
| 119 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.13214326 |
| 120 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.11531669 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.11516941 |
| 122 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.11405800 |
| 123 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.10880030 |
| 124 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.10794408 |
| 125 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.09847015 |
| 126 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.09779506 |
| 127 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.09290679 |
| 128 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.08334736 |
| 129 | Phototransduction_Homo sapiens_hsa04744 | 0.07898895 |
| 130 | Asthma_Homo sapiens_hsa05310 | 0.07894217 |
| 131 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.07816545 |
| 132 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.07649701 |
| 133 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.07300643 |
| 134 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.06938823 |

