RSL24D1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.90068519
2regulation of regulatory T cell differentiation (GO:0045589)9.43578007
3negative regulation of B cell apoptotic process (GO:0002903)8.57451510
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.47059277
5positive regulation of interleukin-17 production (GO:0032740)7.44000496
6regulation of isotype switching to IgG isotypes (GO:0048302)7.29796783
7regulation of immunoglobulin secretion (GO:0051023)5.72896373
8regulation of B cell apoptotic process (GO:0002902)5.34624801
9positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.93530126
10positive regulation of megakaryocyte differentiation (GO:0045654)4.87446517
11signal peptide processing (GO:0006465)4.83056333
12water-soluble vitamin biosynthetic process (GO:0042364)4.60254534
13positive regulation of isotype switching (GO:0045830)4.40929106
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38383671
15ATP synthesis coupled proton transport (GO:0015986)4.38383671
16positive regulation of DNA recombination (GO:0045911)4.27200332
17regulation of memory T cell differentiation (GO:0043380)4.09536741
18response to pheromone (GO:0019236)4.00642660
19positive regulation of activated T cell proliferation (GO:0042104)3.91736387
20proteasome assembly (GO:0043248)3.79593753
21negative regulation of lymphocyte apoptotic process (GO:0070229)3.73680811
22regulation of interleukin-17 production (GO:0032660)3.69463533
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68073663
24positive regulation of immunoglobulin mediated immune response (GO:0002891)3.67038605
25positive regulation of B cell mediated immunity (GO:0002714)3.67038605
26positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.61141636
27positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.60556774
28ribosome assembly (GO:0042255)3.55545197
29ribosomal small subunit assembly (GO:0000028)3.44253722
30negative regulation of heart contraction (GO:0045822)3.38622281
31cell wall macromolecule metabolic process (GO:0044036)3.35615974
32regulation of isotype switching (GO:0045191)3.33999339
33protein neddylation (GO:0045116)3.31863888
34chaperone-mediated protein transport (GO:0072321)3.29915494
35regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.27906878
36positive regulation of interferon-gamma production (GO:0032729)3.26058058
37cellular response to exogenous dsRNA (GO:0071360)3.21861812
38ribosomal large subunit biogenesis (GO:0042273)3.17691256
39regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.07565658
40positive thymic T cell selection (GO:0045059)3.05618309
41DNA damage response, detection of DNA damage (GO:0042769)3.03757250
42platelet dense granule organization (GO:0060155)3.00666212
43respiratory chain complex IV assembly (GO:0008535)2.97364964
44positive regulation of tissue remodeling (GO:0034105)2.92445561
45negative regulation of mast cell activation (GO:0033004)2.88937730
46cellular response to interferon-beta (GO:0035458)2.87163634
47positive regulation of JAK-STAT cascade (GO:0046427)2.82934590
48positive regulation of cell fate commitment (GO:0010455)2.81361561
49regulation of activated T cell proliferation (GO:0046006)2.78406772
50positive regulation of T cell migration (GO:2000406)2.78080080
51positive regulation of B cell proliferation (GO:0030890)2.77901532
52positive regulation of chemokine biosynthetic process (GO:0045080)2.77794575
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.76973732
54immunoglobulin mediated immune response (GO:0016064)2.76952768
55B cell mediated immunity (GO:0019724)2.76922378
56regulation of immunoglobulin mediated immune response (GO:0002889)2.76330354
57chaperone mediated protein folding requiring cofactor (GO:0051085)2.76256741
58plasma membrane fusion (GO:0045026)2.74909212
59protein-cofactor linkage (GO:0018065)2.73042412
60positive regulation of T cell apoptotic process (GO:0070234)2.72278769
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71322326
62negative regulation of T cell differentiation in thymus (GO:0033085)2.66115500
63DNA deamination (GO:0045006)2.66066716
64regulation of non-canonical Wnt signaling pathway (GO:2000050)2.64134067
65regulation of B cell mediated immunity (GO:0002712)2.63941532
66embryonic hemopoiesis (GO:0035162)2.62268911
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61312042
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61312042
69ATP biosynthetic process (GO:0006754)2.60447771
70serotonin receptor signaling pathway (GO:0007210)2.58135476
71cotranslational protein targeting to membrane (GO:0006613)2.57807972
72regulation of podosome assembly (GO:0071801)2.57577399
73establishment of protein localization to mitochondrial membrane (GO:0090151)2.57573562
74positive regulation of lymphocyte migration (GO:2000403)2.56681860
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.55716184
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55561621
77protein targeting to ER (GO:0045047)2.55473016
78cellular biogenic amine catabolic process (GO:0042402)2.55216406
79amine catabolic process (GO:0009310)2.55216406
80positive regulation of lymphocyte mediated immunity (GO:0002708)2.54837783
81respiratory electron transport chain (GO:0022904)2.52845311
82DNA catabolic process, exonucleolytic (GO:0000738)2.52285886
83regulation of B cell proliferation (GO:0030888)2.51832379
84regulation of lymphocyte apoptotic process (GO:0070228)2.51305469
85telomere maintenance via telomerase (GO:0007004)2.51290825
86positive regulation of dendritic spine development (GO:0060999)2.51021144
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.49542933
88electron transport chain (GO:0022900)2.49168898
89pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.48646162
90UMP biosynthetic process (GO:0006222)2.48646162
91pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.48646162
92UMP metabolic process (GO:0046049)2.48646162
93behavioral response to nicotine (GO:0035095)2.48570411
94maturation of SSU-rRNA (GO:0030490)2.47025698
95positive regulation of immunoglobulin production (GO:0002639)2.46959179
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.46086827
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.45978843
98positive regulation of defense response to virus by host (GO:0002230)2.45734467
99protein deneddylation (GO:0000338)2.44602269
100negative regulation of leukocyte apoptotic process (GO:2000107)2.43859061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.95768570
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.39402492
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.38167369
4TAF15_26573619_Chip-Seq_HEK293_Human3.23127841
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94820591
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92904436
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85803983
8ELK1_19687146_ChIP-ChIP_HELA_Human2.49626138
9VDR_22108803_ChIP-Seq_LS180_Human2.47864808
10VDR_23849224_ChIP-Seq_CD4+_Human2.45302131
11EWS_26573619_Chip-Seq_HEK293_Human2.42937647
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30517956
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.22232809
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16960954
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.13541988
16FOXP3_21729870_ChIP-Seq_TREG_Human2.05125470
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03053397
18ZNF274_21170338_ChIP-Seq_K562_Hela2.02747790
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.00727160
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97063002
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.96275788
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87646317
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85733489
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83866787
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82057658
26CIITA_25753668_ChIP-Seq_RAJI_Human1.73633089
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66032496
28P300_19829295_ChIP-Seq_ESCs_Human1.64699151
29IGF1R_20145208_ChIP-Seq_DFB_Human1.64404376
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60979358
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.60588108
32MYC_18940864_ChIP-ChIP_HL60_Human1.58045839
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53988328
34ER_23166858_ChIP-Seq_MCF-7_Human1.53774880
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53236708
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50970331
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49730131
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49273844
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47840373
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44393026
41TP53_22573176_ChIP-Seq_HFKS_Human1.44231152
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.43158802
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41320134
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40541612
45BCAT_22108803_ChIP-Seq_LS180_Human1.40347848
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39833551
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.39833551
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38950203
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38002779
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37358156
51SOX2_19829295_ChIP-Seq_ESCs_Human1.37358156
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.35370266
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33554682
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32878899
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32858922
56FUS_26573619_Chip-Seq_HEK293_Human1.30178354
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29910849
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28924693
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28924693
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28787659
61GATA3_27048872_Chip-Seq_THYMUS_Human1.27140875
62TTF2_22483619_ChIP-Seq_HELA_Human1.27019487
63GATA3_26560356_Chip-Seq_TH2_Human1.26077531
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23236778
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22915114
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22136277
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19590317
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16396546
69CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12464146
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11042370
71XRN2_22483619_ChIP-Seq_HELA_Human1.10206420
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08940150
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08824414
74CBP_20019798_ChIP-Seq_JUKART_Human1.08824414
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.08480233
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07160459
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.06679879
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05991704
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05577389
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05019882
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03892618
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03867722
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02341013
84IRF1_19129219_ChIP-ChIP_H3396_Human1.02036911
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01681979
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.01634875
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01388396
88MYC_19829295_ChIP-Seq_ESCs_Human1.01039839
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99825288
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99451576
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98721834
92TAF2_19829295_ChIP-Seq_ESCs_Human0.95179596
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93404628
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93137585
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.92868045
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92820089
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.91296961
98DCP1A_22483619_ChIP-Seq_HELA_Human0.90305343
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.89968662
100RNF2_27304074_Chip-Seq_NSC_Mouse0.89504933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001853_heart_inflammation5.68508895
2MP0001835_abnormal_antigen_presentation4.58771268
3MP0000465_gastrointestinal_hemorrhage4.43885458
4MP0003300_gastrointestinal_ulcer4.40967417
5MP0002138_abnormal_hepatobiliary_system4.40698782
6MP0005671_abnormal_response_to3.52370962
7MP0004147_increased_porphyrin_level3.37838713
8MP0005645_abnormal_hypothalamus_physiol2.76430344
9MP0000604_amyloidosis2.53184514
10MP0004145_abnormal_muscle_electrophysio2.10627796
11MP0002148_abnormal_hypersensitivity_rea2.08802834
12MP0002736_abnormal_nociception_after1.96655080
13MP0010030_abnormal_orbit_morphology1.94990311
14MP0009333_abnormal_splenocyte_physiolog1.92942459
15MP0003183_abnormal_peptide_metabolism1.83649915
16MP0006292_abnormal_olfactory_placode1.74762297
17MP0003011_delayed_dark_adaptation1.74344566
18MP0001968_abnormal_touch/_nociception1.73222433
19MP0004133_heterotaxia1.66381464
20MP0005084_abnormal_gallbladder_morpholo1.58966617
21MP0001800_abnormal_humoral_immune1.57231318
22MP0002638_abnormal_pupillary_reflex1.54914230
23MP0000516_abnormal_urinary_system1.53655040
24MP0005367_renal/urinary_system_phenotyp1.53655040
25MP0001873_stomach_inflammation1.51251315
26MP0005387_immune_system_phenotype1.46315329
27MP0001790_abnormal_immune_system1.46315329
28MP0009046_muscle_twitch1.43324736
29MP0003786_premature_aging1.39590125
30MP0009379_abnormal_foot_pigmentation1.32901803
31MP0005075_abnormal_melanosome_morpholog1.29015712
32MP0002405_respiratory_system_inflammati1.26512792
33MP0001542_abnormal_bone_strength1.25669904
34MP0006072_abnormal_retinal_apoptosis1.24350926
35MP0002837_dystrophic_cardiac_calcinosis1.16045984
36MP0003045_fibrosis1.15080462
37MP0003195_calcinosis1.11842035
38MP0009785_altered_susceptibility_to1.11196133
39MP0002272_abnormal_nervous_system1.08652442
40MP0001502_abnormal_circadian_rhythm1.07712364
41MP0002234_abnormal_pharynx_morphology1.07451621
42MP0000013_abnormal_adipose_tissue1.06684856
43MP0003763_abnormal_thymus_physiology1.02889278
44MP0005253_abnormal_eye_physiology1.02805971
45MP0008875_abnormal_xenobiotic_pharmacok1.00170179
46MP0008872_abnormal_physiological_respon0.98862059
47MP0009053_abnormal_anal_canal0.96528984
48MP0005167_abnormal_blood-brain_barrier0.95023563
49MP0004142_abnormal_muscle_tone0.94694934
50MP0003806_abnormal_nucleotide_metabolis0.93879090
51MP0003252_abnormal_bile_duct0.93441226
52MP0005000_abnormal_immune_tolerance0.92525535
53MP0002452_abnormal_antigen_presenting0.91346658
54MP0001845_abnormal_inflammatory_respons0.88806206
55MP0002723_abnormal_immune_serum0.87853039
56MP0001905_abnormal_dopamine_level0.87443668
57MP0002420_abnormal_adaptive_immunity0.87132126
58MP0004957_abnormal_blastocyst_morpholog0.86700845
59MP0010155_abnormal_intestine_physiology0.85931624
60MP0001299_abnormal_eye_distance/0.85359442
61MP0002166_altered_tumor_susceptibility0.85104659
62MP0003119_abnormal_digestive_system0.84938372
63MP0005423_abnormal_somatic_nervous0.84697016
64MP0001188_hyperpigmentation0.84088057
65MP0005379_endocrine/exocrine_gland_phen0.84082074
66MP0004742_abnormal_vestibular_system0.82069276
67MP0001819_abnormal_immune_cell0.81463554
68MP0001293_anophthalmia0.78161140
69MP0003866_abnormal_defecation0.77685183
70MP0003638_abnormal_response/metabolism_0.77487659
71MP0000631_abnormal_neuroendocrine_gland0.76875194
72MP0001501_abnormal_sleep_pattern0.76746261
73MP0000685_abnormal_immune_system0.76616435
74MP0002277_abnormal_respiratory_mucosa0.75574759
75MP0001881_abnormal_mammary_gland0.75206464
76MP0002160_abnormal_reproductive_system0.74749581
77MP0005551_abnormal_eye_electrophysiolog0.74183653
78MP0002006_tumorigenesis0.74104906
79MP0009745_abnormal_behavioral_response0.73021017
80MP0000689_abnormal_spleen_morphology0.71877338
81MP0004019_abnormal_vitamin_homeostasis0.71039315
82MP0002398_abnormal_bone_marrow0.71028476
83MP0001440_abnormal_grooming_behavior0.69901642
84MP0003567_abnormal_fetal_cardiomyocyte0.69889326
85MP0005389_reproductive_system_phenotype0.69833847
86MP0001486_abnormal_startle_reflex0.66196276
87MP0001661_extended_life_span0.65960345
88MP0002693_abnormal_pancreas_physiology0.65309790
89MP0002735_abnormal_chemical_nociception0.64899055
90MP0005025_abnormal_response_to0.63256364
91MP0004782_abnormal_surfactant_physiolog0.63085545
92MP0002102_abnormal_ear_morphology0.63042044
93MP0001664_abnormal_digestion0.62801578
94MP0005636_abnormal_mineral_homeostasis0.61517903
95MP0001919_abnormal_reproductive_system0.60923013
96MP0001984_abnormal_olfaction0.60432900
97MP0008058_abnormal_DNA_repair0.59129082
98MP0002722_abnormal_immune_system0.58429620
99MP0003878_abnormal_ear_physiology0.57626512
100MP0005377_hearing/vestibular/ear_phenot0.57626512

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.78106638
2Congenital, generalized hypertrichosis (HP:0004540)4.74014213
33-Methylglutaconic aciduria (HP:0003535)4.32221622
4Spontaneous abortion (HP:0005268)3.63654722
5Thrombocytosis (HP:0001894)3.60360242
6Increased IgM level (HP:0003496)3.44975392
7Sex reversal (HP:0012245)3.28564884
8Abnormal sex determination (HP:0012244)3.28564884
9Large eyes (HP:0001090)3.27814438
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25875692
11Renal cortical cysts (HP:0000803)3.24613724
12Mesomelia (HP:0003027)3.17622418
13Mitochondrial inheritance (HP:0001427)3.09607542
14Abnormality of B cell number (HP:0010975)3.03002723
15Acute necrotizing encephalopathy (HP:0006965)2.95876764
16Constricted visual fields (HP:0001133)2.94645289
17Chest pain (HP:0100749)2.82530210
18Increased CSF lactate (HP:0002490)2.79354481
19Anterior segment dysgenesis (HP:0007700)2.78853573
20Hepatocellular necrosis (HP:0001404)2.78644577
21Renal Fanconi syndrome (HP:0001994)2.72365384
22Abnormality of the prostate (HP:0008775)2.66747714
23Stomatitis (HP:0010280)2.59082283
24Progressive macrocephaly (HP:0004481)2.58426476
25Increased hepatocellular lipid droplets (HP:0006565)2.53391905
26Abnormality of the renal cortex (HP:0011035)2.52787874
27Intestinal atresia (HP:0011100)2.52774492
28Type I transferrin isoform profile (HP:0003642)2.47910772
29Absent eyebrow (HP:0002223)2.46573426
30Abnormal mitochondria in muscle tissue (HP:0008316)2.44832180
31Thyroiditis (HP:0100646)2.42596911
32Hepatic necrosis (HP:0002605)2.41950792
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41463779
34Abnormality of alanine metabolism (HP:0010916)2.41463779
35Hyperalaninemia (HP:0003348)2.41463779
36Methylmalonic acidemia (HP:0002912)2.40929509
37Reduced antithrombin III activity (HP:0001976)2.40399123
38IgG deficiency (HP:0004315)2.39563829
39Autoimmune hemolytic anemia (HP:0001890)2.38826459
40Hypoplasia of the radius (HP:0002984)2.35390085
41Cleft eyelid (HP:0000625)2.33960794
42Poor speech (HP:0002465)2.32978634
43Pendular nystagmus (HP:0012043)2.32743905
44Pulmonary fibrosis (HP:0002206)2.32075592
45Exertional dyspnea (HP:0002875)2.29633989
46Diplopia (HP:0000651)2.28162515
47Abnormality of binocular vision (HP:0011514)2.28162515
48Abnormality of T cell number (HP:0011839)2.25705343
49Severe combined immunodeficiency (HP:0004430)2.23005361
50Acute encephalopathy (HP:0006846)2.21645167
51Hypoproteinemia (HP:0003075)2.17711195
52Cerebral edema (HP:0002181)2.15471842
53Abnormal rod and cone electroretinograms (HP:0008323)2.15174256
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.11909032
55Pancreatic cysts (HP:0001737)2.11693310
56Hypergammaglobulinemia (HP:0010702)2.09859799
57Abolished electroretinogram (ERG) (HP:0000550)2.09668088
58B lymphocytopenia (HP:0010976)2.09502473
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06655109
60Ureteral stenosis (HP:0000071)2.01696551
61Lipid accumulation in hepatocytes (HP:0006561)2.00949578
62Attenuation of retinal blood vessels (HP:0007843)1.99587280
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99094448
64Abnormal protein N-linked glycosylation (HP:0012347)1.99094448
65Abnormal protein glycosylation (HP:0012346)1.99094448
66Abnormal glycosylation (HP:0012345)1.99094448
67Abnormal number of erythroid precursors (HP:0012131)1.96882933
68Hyperglycinemia (HP:0002154)1.96443078
69Ureteral obstruction (HP:0006000)1.96297924
70Neutropenia (HP:0001875)1.93540153
71Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92012803
72Woolly hair (HP:0002224)1.91867350
73Hypoglycemic seizures (HP:0002173)1.90266970
74Chronic diarrhea (HP:0002028)1.90185199
75Methylmalonic aciduria (HP:0012120)1.89533546
76Aplastic anemia (HP:0001915)1.88620916
77Pancreatic fibrosis (HP:0100732)1.88511148
78Abnormality of eosinophils (HP:0001879)1.86972469
79Forearm undergrowth (HP:0009821)1.86942955
80Bile duct proliferation (HP:0001408)1.86035652
81Abnormal biliary tract physiology (HP:0012439)1.86035652
82Pulmonary infiltrates (HP:0002113)1.83503183
83Optic disc pallor (HP:0000543)1.83470518
84Pancytopenia (HP:0001876)1.82888640
85Abnormality of vitamin B metabolism (HP:0004340)1.81849756
86T lymphocytopenia (HP:0005403)1.80912032
87Abnormal drinking behavior (HP:0030082)1.80424170
88Polydipsia (HP:0001959)1.80424170
89Beaking of vertebral bodies (HP:0004568)1.79541428
90Focal motor seizures (HP:0011153)1.79541170
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.78502323
92Delayed CNS myelination (HP:0002188)1.77918263
93Meningitis (HP:0001287)1.77811712
94Reticulocytopenia (HP:0001896)1.77274644
95Nephronophthisis (HP:0000090)1.76574308
96Symptomatic seizures (HP:0011145)1.76214608
97Arterial thrombosis (HP:0004420)1.74324409
98Abnormality of cells of the erythroid lineage (HP:0012130)1.73760325
99Hypothermia (HP:0002045)1.72741856
100Median cleft lip (HP:0000161)1.69131130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.18326169
2FES4.84502304
3TLK14.05204296
4MAP4K13.20090393
5MAP3K122.76640392
6FRK2.71576473
7MST42.51899818
8BMPR1B2.40318354
9FER2.25966053
10NEK12.25066860
11WNK32.18316894
12ADRBK22.17533573
13BLK2.01032723
14ZAK1.86912073
15EIF2AK31.84773220
16VRK11.84427795
17TEC1.77725404
18GRK11.65056449
19MKNK21.60641299
20SCYL21.59017518
21VRK21.56801906
22TAF11.56703690
23ZAP701.52236910
24CSK1.45149438
25ITK1.40853022
26STK38L1.39589313
27MKNK11.36850521
28RPS6KA51.36011552
29BMPR21.28100015
30DYRK21.24322342
31SRPK11.22079482
32IKBKB1.10047530
33PASK1.08673463
34INSRR1.06810934
35NEK91.02925068
36PLK21.02202944
37MAP4K21.02069048
38CAMK11.01519232
39PAK40.99349521
40BUB10.94449476
41MAP3K90.92040933
42NME10.90272787
43CDK190.88858369
44TSSK60.86686969
45PRKCE0.86470738
46RPS6KA40.86343449
47ERBB30.84042168
48SYK0.79586987
49ALK0.77765782
50PLK30.75948691
51GRK60.74117292
52KDR0.74014932
53PIK3CG0.72922077
54CHUK0.72734250
55SIK20.70452270
56TGFBR10.69695201
57GRK70.67507297
58LYN0.66377187
59CSNK2A20.66271287
60PLK40.65118828
61ATR0.63730633
62PAK30.62260272
63MAP3K140.58845470
64PDK20.55884908
65OXSR10.53209195
66DYRK1A0.52321086
67IKBKE0.49277268
68TIE10.46616535
69WNK40.44450510
70BTK0.43130738
71CDC70.42832006
72STK240.42303161
73PLK10.41391659
74CSNK2A10.41153372
75PINK10.39612842
76PRKCG0.39587067
77TNIK0.37142439
78LCK0.36910533
79GRK50.35927061
80PRKACA0.35693869
81PRKCQ0.33002422
82ADRBK10.32908866
83MYLK0.32778194
84PRKACG0.32247427
85ACVR1B0.32020311
86OBSCN0.31446029
87BCKDK0.31294105
88PRKCA0.30331899
89FGFR20.29432746
90EGFR0.29393338
91AKT30.28386505
92PHKG20.28004658
93PHKG10.28004658
94CSNK1E0.27164162
95ATM0.27095766
96DAPK30.27082288
97PRKACB0.25926610
98NUAK10.25672564
99CSNK1A10.25263471
100IGF1R0.24690594

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.37940490
2Allograft rejection_Homo sapiens_hsa053304.61587331
3Autoimmune thyroid disease_Homo sapiens_hsa053204.49455527
4Graft-versus-host disease_Homo sapiens_hsa053324.33575293
5Type I diabetes mellitus_Homo sapiens_hsa049403.99999448
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.68443097
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.91667745
8Systemic lupus erythematosus_Homo sapiens_hsa053222.48109666
9Oxidative phosphorylation_Homo sapiens_hsa001902.44898757
10Proteasome_Homo sapiens_hsa030502.43818541
11Ribosome_Homo sapiens_hsa030102.36556674
12Rheumatoid arthritis_Homo sapiens_hsa053232.29695533
13Protein export_Homo sapiens_hsa030602.27130622
14Hematopoietic cell lineage_Homo sapiens_hsa046402.22232248
15Parkinsons disease_Homo sapiens_hsa050122.06181191
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00909512
17Staphylococcus aureus infection_Homo sapiens_hsa051501.98691505
18Antigen processing and presentation_Homo sapiens_hsa046121.76876834
19One carbon pool by folate_Homo sapiens_hsa006701.56544492
20Viral myocarditis_Homo sapiens_hsa054161.50927957
21Primary immunodeficiency_Homo sapiens_hsa053401.44412700
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25609136
23Huntingtons disease_Homo sapiens_hsa050161.24045062
24Alzheimers disease_Homo sapiens_hsa050101.18831917
25Basal transcription factors_Homo sapiens_hsa030221.18149554
26Alcoholism_Homo sapiens_hsa050341.17202439
27Leishmaniasis_Homo sapiens_hsa051401.11859633
28RNA polymerase_Homo sapiens_hsa030201.03480678
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02799984
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96213337
31Cardiac muscle contraction_Homo sapiens_hsa042600.95227785
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80741105
33Phototransduction_Homo sapiens_hsa047440.76246468
34Maturity onset diabetes of the young_Homo sapiens_hsa049500.74730720
35Peroxisome_Homo sapiens_hsa041460.74687061
36RNA transport_Homo sapiens_hsa030130.73859709
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.72749860
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71090989
39Pyrimidine metabolism_Homo sapiens_hsa002400.71054152
40Base excision repair_Homo sapiens_hsa034100.70639478
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69829083
42Homologous recombination_Homo sapiens_hsa034400.67706778
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65729046
44Linoleic acid metabolism_Homo sapiens_hsa005910.59569526
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59190880
46Nucleotide excision repair_Homo sapiens_hsa034200.54793807
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.53986633
48RNA degradation_Homo sapiens_hsa030180.50401148
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50315118
50T cell receptor signaling pathway_Homo sapiens_hsa046600.50239000
51Circadian rhythm_Homo sapiens_hsa047100.48622123
52Herpes simplex infection_Homo sapiens_hsa051680.47130028
53Taste transduction_Homo sapiens_hsa047420.47086932
54Phagosome_Homo sapiens_hsa041450.46471635
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45810765
56Retinol metabolism_Homo sapiens_hsa008300.44955112
57Spliceosome_Homo sapiens_hsa030400.43606724
58Ether lipid metabolism_Homo sapiens_hsa005650.42543693
59Glutathione metabolism_Homo sapiens_hsa004800.41805490
60Purine metabolism_Homo sapiens_hsa002300.41235055
61Chemical carcinogenesis_Homo sapiens_hsa052040.39949405
62Collecting duct acid secretion_Homo sapiens_hsa049660.39377683
63Nitrogen metabolism_Homo sapiens_hsa009100.37908280
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37362627
65Tuberculosis_Homo sapiens_hsa051520.36017009
66Salivary secretion_Homo sapiens_hsa049700.35793621
67Nicotine addiction_Homo sapiens_hsa050330.35774180
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34654131
69Histidine metabolism_Homo sapiens_hsa003400.33178012
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.31872142
71Tryptophan metabolism_Homo sapiens_hsa003800.31517138
72Selenocompound metabolism_Homo sapiens_hsa004500.30938865
73Glycerolipid metabolism_Homo sapiens_hsa005610.29064723
74Serotonergic synapse_Homo sapiens_hsa047260.29049326
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28428594
76HTLV-I infection_Homo sapiens_hsa051660.27673468
77Influenza A_Homo sapiens_hsa051640.26501877
78Sulfur metabolism_Homo sapiens_hsa009200.26464666
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26197357
80Mineral absorption_Homo sapiens_hsa049780.25629300
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25346687
82Fatty acid elongation_Homo sapiens_hsa000620.25182283
83Olfactory transduction_Homo sapiens_hsa047400.24994173
84Butanoate metabolism_Homo sapiens_hsa006500.24895454
85Salmonella infection_Homo sapiens_hsa051320.24221915
86Epstein-Barr virus infection_Homo sapiens_hsa051690.24038427
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23893084
88Lysine degradation_Homo sapiens_hsa003100.22873585
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22812743
90Metabolic pathways_Homo sapiens_hsa011000.22363530
91Legionellosis_Homo sapiens_hsa051340.21708671
92Measles_Homo sapiens_hsa051620.21687397
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20232838
94Viral carcinogenesis_Homo sapiens_hsa052030.18989452
95TGF-beta signaling pathway_Homo sapiens_hsa043500.18821944
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.17890463
97beta-Alanine metabolism_Homo sapiens_hsa004100.16281747
98Non-homologous end-joining_Homo sapiens_hsa034500.16281390
99GABAergic synapse_Homo sapiens_hsa047270.14876325
100Synaptic vesicle cycle_Homo sapiens_hsa047210.14744458

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