Rank | Gene Set | Z-score |
---|---|---|
1 | sequestering of actin monomers (GO:0042989) | 7.91019550 |
2 | sexual reproduction (GO:0019953) | 7.14189778 |
3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.29328388 |
4 | serotonin receptor signaling pathway (GO:0007210) | 6.09118470 |
5 | chaperone-mediated protein transport (GO:0072321) | 5.19300419 |
6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.18035235 |
7 | protein neddylation (GO:0045116) | 5.09684135 |
8 | DNA ligation (GO:0006266) | 4.96248568 |
9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.79855895 |
10 | ATP synthesis coupled proton transport (GO:0015986) | 4.79855895 |
11 | GDP-mannose metabolic process (GO:0019673) | 4.50936616 |
12 | DNA strand renaturation (GO:0000733) | 4.31016034 |
13 | inner mitochondrial membrane organization (GO:0007007) | 4.16673437 |
14 | glyoxylate metabolic process (GO:0046487) | 4.07228087 |
15 | intraciliary transport (GO:0042073) | 4.05670038 |
16 | DNA topological change (GO:0006265) | 4.04861392 |
17 | CENP-A containing nucleosome assembly (GO:0034080) | 3.96965111 |
18 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.96701196 |
19 | establishment of integrated proviral latency (GO:0075713) | 3.95619662 |
20 | viral mRNA export from host cell nucleus (GO:0046784) | 3.85529948 |
21 | chromatin remodeling at centromere (GO:0031055) | 3.85245170 |
22 | folic acid metabolic process (GO:0046655) | 3.83330691 |
23 | GTP biosynthetic process (GO:0006183) | 3.74928693 |
24 | UTP metabolic process (GO:0046051) | 3.70264380 |
25 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 3.66307208 |
26 | oxaloacetate metabolic process (GO:0006107) | 3.64044715 |
27 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.63482485 |
28 | folic acid transport (GO:0015884) | 3.54019488 |
29 | DNA deamination (GO:0045006) | 3.52328771 |
30 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.52133330 |
31 | ribosomal large subunit biogenesis (GO:0042273) | 3.48943299 |
32 | UTP biosynthetic process (GO:0006228) | 3.47661464 |
33 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.42432080 |
34 | artery smooth muscle contraction (GO:0014824) | 3.41459500 |
35 | maturation of 5.8S rRNA (GO:0000460) | 3.37973323 |
36 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.34058396 |
37 | respiratory electron transport chain (GO:0022904) | 3.29530691 |
38 | response to nitrosative stress (GO:0051409) | 3.28712020 |
39 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 3.27384561 |
40 | electron transport chain (GO:0022900) | 3.25074346 |
41 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.24981268 |
42 | ribonucleoprotein complex disassembly (GO:0032988) | 3.23477819 |
43 | intracellular protein transmembrane import (GO:0044743) | 3.20204339 |
44 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.18630963 |
45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.16298800 |
46 | DNA strand elongation (GO:0022616) | 3.14926484 |
47 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.13684948 |
48 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.11869292 |
49 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.11844576 |
50 | replication fork processing (GO:0031297) | 3.11699443 |
51 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.10472284 |
52 | telomere maintenance via recombination (GO:0000722) | 3.09848703 |
53 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 3.09394526 |
54 | synapsis (GO:0007129) | 3.07310516 |
55 | CTP metabolic process (GO:0046036) | 3.06730375 |
56 | CTP biosynthetic process (GO:0006241) | 3.06730375 |
57 | microtubule depolymerization (GO:0007019) | 3.06175612 |
58 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.05255991 |
59 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 3.03212388 |
60 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.01371221 |
61 | viral transcription (GO:0019083) | 2.99192886 |
62 | drug transport (GO:0015893) | 2.98516262 |
63 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.97321444 |
64 | translational termination (GO:0006415) | 2.97048008 |
65 | lipid particle organization (GO:0034389) | 2.96025168 |
66 | prenylation (GO:0097354) | 2.96005864 |
67 | protein prenylation (GO:0018342) | 2.96005864 |
68 | histone exchange (GO:0043486) | 2.95263308 |
69 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.95225313 |
70 | vascular smooth muscle contraction (GO:0014829) | 2.94347384 |
71 | pyrimidine nucleoside biosynthetic process (GO:0046134) | 2.94178158 |
72 | respiratory chain complex IV assembly (GO:0008535) | 2.93529078 |
73 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.92745482 |
74 | organelle disassembly (GO:1903008) | 2.92390272 |
75 | ribosomal small subunit assembly (GO:0000028) | 2.92105879 |
76 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.91793370 |
77 | termination of RNA polymerase III transcription (GO:0006386) | 2.91548053 |
78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.91548053 |
79 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.91507677 |
80 | transcription from RNA polymerase I promoter (GO:0006360) | 2.91370757 |
81 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.90826172 |
82 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 2.89858946 |
83 | non-recombinational repair (GO:0000726) | 2.89392644 |
84 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.89392644 |
85 | regulation of DNA endoreduplication (GO:0032875) | 2.87819317 |
86 | pyrimidine ribonucleotide biosynthetic process (GO:0009220) | 2.87712637 |
87 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.87111183 |
88 | cotranslational protein targeting to membrane (GO:0006613) | 2.86157943 |
89 | indole-containing compound catabolic process (GO:0042436) | 2.85910373 |
90 | indolalkylamine catabolic process (GO:0046218) | 2.85910373 |
91 | tryptophan catabolic process (GO:0006569) | 2.85910373 |
92 | protein targeting to ER (GO:0045047) | 2.85865775 |
93 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.85411676 |
94 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.84985559 |
95 | phasic smooth muscle contraction (GO:0014821) | 2.84749939 |
96 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.83251914 |
97 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.82685273 |
98 | tonic smooth muscle contraction (GO:0014820) | 2.82680681 |
99 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.82219426 |
100 | mitotic recombination (GO:0006312) | 2.80484460 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.54790292 |
2 | VDR_22108803_ChIP-Seq_LS180_Human | 4.92085801 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.27977468 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.71247839 |
5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.62649170 |
6 | IGF1R_20145208_ChIP-Seq_DFB_Human | 3.31221751 |
7 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 3.29903075 |
8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.23307507 |
9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.93178634 |
10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.87025289 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.81957822 |
12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.47072615 |
13 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.40327612 |
14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.38780856 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.34739848 |
16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33060988 |
17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.29067577 |
18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.26303081 |
19 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.22279944 |
20 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.20850971 |
21 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.15378643 |
22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.14081700 |
23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.12521612 |
24 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.09647951 |
25 | FUS_26573619_Chip-Seq_HEK293_Human | 1.98338833 |
26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.94311044 |
27 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.91052832 |
28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.88455451 |
29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.88002975 |
30 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.83573680 |
31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.81852687 |
32 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.79558301 |
33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.77719755 |
34 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.74155850 |
35 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.71051850 |
36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.66771321 |
37 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.66026575 |
38 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.65354447 |
39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.65318594 |
40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.63075131 |
41 | EWS_26573619_Chip-Seq_HEK293_Human | 1.60132256 |
42 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.58603671 |
43 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.57500534 |
44 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55018299 |
45 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.53493267 |
46 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.49540924 |
47 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.49256684 |
48 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.42431748 |
49 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.42003191 |
50 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.41846360 |
51 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.34020173 |
52 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.33538274 |
53 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.30422366 |
54 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.26195842 |
55 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.25516652 |
56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23150249 |
57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23150249 |
58 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.22778773 |
59 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.22710839 |
60 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.22046810 |
61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.20819075 |
62 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.20754779 |
63 | P300_19829295_ChIP-Seq_ESCs_Human | 1.19564557 |
64 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.17744862 |
65 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.17102689 |
66 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.16491094 |
67 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.12183831 |
68 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10958163 |
69 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.10906227 |
70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.09269031 |
71 | JUN_21703547_ChIP-Seq_K562_Human | 1.08446003 |
72 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.08154459 |
73 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.08148034 |
74 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.07986713 |
75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02652867 |
76 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.01646354 |
77 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.97868435 |
78 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.95314467 |
79 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.95047919 |
80 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.93898991 |
81 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93524015 |
82 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.91645717 |
83 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88191199 |
84 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.87633584 |
85 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.87214007 |
86 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.86931588 |
87 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.86924052 |
88 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.85732465 |
89 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.84143691 |
90 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.84142274 |
91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83122366 |
92 | AR_25329375_ChIP-Seq_VCAP_Human | 0.83052345 |
93 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.81513448 |
94 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.80673873 |
95 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80220722 |
96 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.79823000 |
97 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.79775164 |
98 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.79678600 |
99 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.78614471 |
100 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.78238344 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0000566_synostosis | 6.01653955 |
2 | MP0009780_abnormal_chondrocyte_physiolo | 5.30523176 |
3 | MP0009379_abnormal_foot_pigmentation | 4.12360383 |
4 | MP0005171_absent_coat_pigmentation | 4.00978108 |
5 | MP0003183_abnormal_peptide_metabolism | 3.78811609 |
6 | MP0002938_white_spotting | 3.68306442 |
7 | MP0010094_abnormal_chromosome_stability | 3.41361655 |
8 | MP0005360_urolithiasis | 3.17908356 |
9 | MP0005075_abnormal_melanosome_morpholog | 3.06408685 |
10 | MP0002837_dystrophic_cardiac_calcinosis | 2.94925862 |
11 | MP0008058_abnormal_DNA_repair | 2.91896916 |
12 | MP0003136_yellow_coat_color | 2.57255751 |
13 | MP0002736_abnormal_nociception_after | 2.49185883 |
14 | MP0008260_abnormal_autophagy | 2.37398602 |
15 | MP0008057_abnormal_DNA_replication | 2.31790342 |
16 | MP0005248_abnormal_Harderian_gland | 2.12480059 |
17 | MP0004147_increased_porphyrin_level | 2.10865359 |
18 | MP0000383_abnormal_hair_follicle | 1.80345317 |
19 | MP0010678_abnormal_skin_adnexa | 1.71761539 |
20 | MP0000015_abnormal_ear_pigmentation | 1.71565213 |
21 | MP0003011_delayed_dark_adaptation | 1.71472434 |
22 | MP0008789_abnormal_olfactory_epithelium | 1.66558540 |
23 | MP0005408_hypopigmentation | 1.59313759 |
24 | MP0005084_abnormal_gallbladder_morpholo | 1.56559888 |
25 | MP0005409_darkened_coat_color | 1.54956898 |
26 | MP0006292_abnormal_olfactory_placode | 1.54898306 |
27 | MP0005174_abnormal_tail_pigmentation | 1.51738668 |
28 | MP0000013_abnormal_adipose_tissue | 1.44952951 |
29 | MP0001293_anophthalmia | 1.42560668 |
30 | MP0003195_calcinosis | 1.36746279 |
31 | MP0008875_abnormal_xenobiotic_pharmacok | 1.33319372 |
32 | MP0002234_abnormal_pharynx_morphology | 1.26077958 |
33 | MP0001968_abnormal_touch/_nociception | 1.25476539 |
34 | MP0003186_abnormal_redox_activity | 1.24166851 |
35 | MP0003122_maternal_imprinting | 1.22704962 |
36 | MP0001529_abnormal_vocalization | 1.18129068 |
37 | MP0008007_abnormal_cellular_replicative | 1.17440488 |
38 | MP0005083_abnormal_biliary_tract | 1.17375075 |
39 | MP0003656_abnormal_erythrocyte_physiolo | 1.16538385 |
40 | MP0002163_abnormal_gland_morphology | 1.13855815 |
41 | MP0002233_abnormal_nose_morphology | 1.12902770 |
42 | MP0006072_abnormal_retinal_apoptosis | 1.11048578 |
43 | MP0001188_hyperpigmentation | 1.08930037 |
44 | MP0000428_abnormal_craniofacial_morphol | 1.08051568 |
45 | MP0002396_abnormal_hematopoietic_system | 1.05972773 |
46 | MP0002638_abnormal_pupillary_reflex | 1.05150812 |
47 | MP0006276_abnormal_autonomic_nervous | 1.04816347 |
48 | MP0005394_taste/olfaction_phenotype | 1.03437859 |
49 | MP0005499_abnormal_olfactory_system | 1.03437859 |
50 | MP0002132_abnormal_respiratory_system | 1.02576833 |
51 | MP0001346_abnormal_lacrimal_gland | 1.02418198 |
52 | MP0002139_abnormal_hepatobiliary_system | 1.01701387 |
53 | MP0005636_abnormal_mineral_homeostasis | 1.00762014 |
54 | MP0002095_abnormal_skin_pigmentation | 1.00376613 |
55 | MP0001324_abnormal_eye_pigmentation | 0.97965969 |
56 | MP0002075_abnormal_coat/hair_pigmentati | 0.96688297 |
57 | MP0003718_maternal_effect | 0.92335899 |
58 | MP0003786_premature_aging | 0.92032862 |
59 | MP0001764_abnormal_homeostasis | 0.89691247 |
60 | MP0002127_abnormal_cardiovascular_syste | 0.89617968 |
61 | MP0004957_abnormal_blastocyst_morpholog | 0.89352201 |
62 | MP0003950_abnormal_plasma_membrane | 0.85319471 |
63 | MP0005645_abnormal_hypothalamus_physiol | 0.84814779 |
64 | MP0005551_abnormal_eye_electrophysiolog | 0.84791053 |
65 | MP0003937_abnormal_limbs/digits/tail_de | 0.84422530 |
66 | MP0005332_abnormal_amino_acid | 0.84158689 |
67 | MP0003878_abnormal_ear_physiology | 0.83420271 |
68 | MP0005377_hearing/vestibular/ear_phenot | 0.83420271 |
69 | MP0006035_abnormal_mitochondrial_morpho | 0.82464135 |
70 | MP0006036_abnormal_mitochondrial_physio | 0.80655746 |
71 | MP0002751_abnormal_autonomic_nervous | 0.80147170 |
72 | MP0008873_increased_physiological_sensi | 0.80126943 |
73 | MP0003077_abnormal_cell_cycle | 0.75435992 |
74 | MP0002971_abnormal_brown_adipose | 0.74432153 |
75 | MP0002876_abnormal_thyroid_physiology | 0.73691340 |
76 | MP0010234_abnormal_vibrissa_follicle | 0.73137714 |
77 | MP0001186_pigmentation_phenotype | 0.73047462 |
78 | MP0001243_abnormal_dermal_layer | 0.72737866 |
79 | MP0008932_abnormal_embryonic_tissue | 0.72513258 |
80 | MP0009697_abnormal_copulation | 0.71860545 |
81 | MP0000427_abnormal_hair_cycle | 0.69093815 |
82 | MP0003121_genomic_imprinting | 0.68776402 |
83 | MP0002697_abnormal_eye_size | 0.67767798 |
84 | MP0000631_abnormal_neuroendocrine_gland | 0.66248812 |
85 | MP0005379_endocrine/exocrine_gland_phen | 0.66007166 |
86 | MP0003252_abnormal_bile_duct | 0.64981236 |
87 | MP0002896_abnormal_bone_mineralization | 0.64365458 |
88 | MP0000003_abnormal_adipose_tissue | 0.63583279 |
89 | MP0003880_abnormal_central_pattern | 0.63222051 |
90 | MP0000647_abnormal_sebaceous_gland | 0.62232199 |
91 | MP0003283_abnormal_digestive_organ | 0.62079852 |
92 | MP0003868_abnormal_feces_composition | 0.61077684 |
93 | MP0004215_abnormal_myocardial_fiber | 0.60728859 |
94 | MP0004134_abnormal_chest_morphology | 0.60364018 |
95 | MP0001881_abnormal_mammary_gland | 0.59791878 |
96 | MP0008995_early_reproductive_senescence | 0.59500570 |
97 | MP0000579_abnormal_nail_morphology | 0.59374949 |
98 | MP0010030_abnormal_orbit_morphology | 0.58189735 |
99 | MP0003942_abnormal_urinary_system | 0.58100284 |
100 | MP0005670_abnormal_white_adipose | 0.57618021 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Reticulocytopenia (HP:0001896) | 5.22514318 |
2 | Popliteal pterygium (HP:0009756) | 4.44476283 |
3 | Increased hepatocellular lipid droplets (HP:0006565) | 4.42565359 |
4 | Congenital, generalized hypertrichosis (HP:0004540) | 4.00132389 |
5 | Metaphyseal dysplasia (HP:0100255) | 3.95555538 |
6 | Disproportionate short-trunk short stature (HP:0003521) | 3.93445685 |
7 | 3-Methylglutaconic aciduria (HP:0003535) | 3.78850169 |
8 | Hypoplastic ischia (HP:0003175) | 3.77041912 |
9 | Short tibia (HP:0005736) | 3.67923595 |
10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.65445660 |
11 | Increased serum pyruvate (HP:0003542) | 3.56408129 |
12 | Abnormal number of erythroid precursors (HP:0012131) | 3.41906901 |
13 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 3.40094757 |
14 | Renal Fanconi syndrome (HP:0001994) | 3.37015471 |
15 | Absent/shortened dynein arms (HP:0200106) | 3.35919583 |
16 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.35919583 |
17 | Abnormality of the ischium (HP:0003174) | 3.25785375 |
18 | Increased CSF lactate (HP:0002490) | 3.23756053 |
19 | Macrocytic anemia (HP:0001972) | 3.03192293 |
20 | Abnormality of glycolysis (HP:0004366) | 3.03000234 |
21 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.02343141 |
22 | Hepatocellular necrosis (HP:0001404) | 2.99423340 |
23 | Mitochondrial inheritance (HP:0001427) | 2.97154734 |
24 | Focal motor seizures (HP:0011153) | 2.95045250 |
25 | Choroideremia (HP:0001139) | 2.93022314 |
26 | Hepatic necrosis (HP:0002605) | 2.91887923 |
27 | Type 2 muscle fiber atrophy (HP:0003554) | 2.87209463 |
28 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.79414427 |
29 | Microglossia (HP:0000171) | 2.76393817 |
30 | Exertional dyspnea (HP:0002875) | 2.65160188 |
31 | Amniotic constriction ring (HP:0009775) | 2.62898790 |
32 | Abnormality of placental membranes (HP:0011409) | 2.62898790 |
33 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.62001270 |
34 | Facial hemangioma (HP:0000329) | 2.55790351 |
35 | Acute encephalopathy (HP:0006846) | 2.52013768 |
36 | Microvesicular hepatic steatosis (HP:0001414) | 2.51369872 |
37 | Abnormal foot bone ossification (HP:0010675) | 2.47554108 |
38 | Abnormal ciliary motility (HP:0012262) | 2.46191011 |
39 | Abnormality of renal resorption (HP:0011038) | 2.45959292 |
40 | Fibular hypoplasia (HP:0003038) | 2.45600423 |
41 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.43207211 |
42 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.41207558 |
43 | Respiratory difficulties (HP:0002880) | 2.39890850 |
44 | Barrel-shaped chest (HP:0001552) | 2.39634726 |
45 | Absent epiphyses (HP:0010577) | 2.39507963 |
46 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.39507963 |
47 | Poor head control (HP:0002421) | 2.37915538 |
48 | Volvulus (HP:0002580) | 2.36579266 |
49 | Acute necrotizing encephalopathy (HP:0006965) | 2.36024502 |
50 | Increased nuchal translucency (HP:0010880) | 2.30759128 |
51 | Abnormality of midbrain morphology (HP:0002418) | 2.30315402 |
52 | Molar tooth sign on MRI (HP:0002419) | 2.30315402 |
53 | Duplicated collecting system (HP:0000081) | 2.30074632 |
54 | Alacrima (HP:0000522) | 2.29399584 |
55 | Muscle fiber atrophy (HP:0100295) | 2.28967243 |
56 | Increased serum lactate (HP:0002151) | 2.28068943 |
57 | Retinal dysplasia (HP:0007973) | 2.26000207 |
58 | Hyperglycinemia (HP:0002154) | 2.21511129 |
59 | Decreased lacrimation (HP:0000633) | 2.21245256 |
60 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.21054045 |
61 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.20644255 |
62 | Hypoplasia of the radius (HP:0002984) | 2.19515830 |
63 | Proximal tubulopathy (HP:0000114) | 2.18149082 |
64 | Pterygium (HP:0001059) | 2.14126170 |
65 | Bell-shaped thorax (HP:0001591) | 2.13879467 |
66 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.13589745 |
67 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.13589745 |
68 | Glycosuria (HP:0003076) | 2.12142701 |
69 | Abnormality of urine glucose concentration (HP:0011016) | 2.12142701 |
70 | Increased intramyocellular lipid droplets (HP:0012240) | 2.09935771 |
71 | Abnormality of DNA repair (HP:0003254) | 2.09932854 |
72 | Pulmonary artery stenosis (HP:0004415) | 2.08956666 |
73 | Lactic acidosis (HP:0003128) | 2.08708195 |
74 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.07410528 |
75 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.07410528 |
76 | Megaloblastic anemia (HP:0001889) | 2.07297274 |
77 | Pallor (HP:0000980) | 2.06899973 |
78 | Hyperphosphaturia (HP:0003109) | 2.06088973 |
79 | Patchy hypopigmentation of hair (HP:0011365) | 2.05152441 |
80 | Abnormality of the renal collecting system (HP:0004742) | 2.03935977 |
81 | Hypoplasia of the pons (HP:0012110) | 2.02479651 |
82 | Facial diplegia (HP:0001349) | 2.00964088 |
83 | Increased corneal curvature (HP:0100692) | 1.97268598 |
84 | Keratoconus (HP:0000563) | 1.97268598 |
85 | Abnormality of cochlea (HP:0000375) | 1.95387385 |
86 | Prolonged partial thromboplastin time (HP:0003645) | 1.94740733 |
87 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.94529962 |
88 | Progressive macrocephaly (HP:0004481) | 1.93952673 |
89 | Abnormality of the anterior horn cell (HP:0006802) | 1.93531063 |
90 | Degeneration of anterior horn cells (HP:0002398) | 1.93531063 |
91 | Constricted visual fields (HP:0001133) | 1.91413700 |
92 | Bifid tongue (HP:0010297) | 1.91045408 |
93 | Generalized aminoaciduria (HP:0002909) | 1.90778934 |
94 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.87018472 |
95 | Testicular atrophy (HP:0000029) | 1.86344087 |
96 | Depressed nasal tip (HP:0000437) | 1.86122488 |
97 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.85216251 |
98 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.83235381 |
99 | Epidermoid cyst (HP:0200040) | 1.81015421 |
100 | Pancytopenia (HP:0001876) | 1.77816112 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NME1 | 4.11356806 |
2 | CASK | 3.55500398 |
3 | CDK8 | 3.48023780 |
4 | MAP4K2 | 3.37636940 |
5 | BRD4 | 3.04252456 |
6 | CCNB1 | 3.01479149 |
7 | ZAK | 2.80299490 |
8 | STK16 | 2.67117171 |
9 | NTRK3 | 2.39560045 |
10 | MST4 | 2.26082365 |
11 | NEK1 | 2.06213986 |
12 | CDK19 | 2.06014084 |
13 | BUB1 | 1.89500099 |
14 | MAP3K10 | 1.85163350 |
15 | WEE1 | 1.82592706 |
16 | TLK1 | 1.79954977 |
17 | PINK1 | 1.78295087 |
18 | VRK2 | 1.73352159 |
19 | MKNK2 | 1.70296548 |
20 | MKNK1 | 1.65517930 |
21 | EIF2AK3 | 1.61264578 |
22 | CDC7 | 1.60013940 |
23 | MAPKAPK3 | 1.56901045 |
24 | WNK3 | 1.53547355 |
25 | WNK4 | 1.52714506 |
26 | BRSK2 | 1.40141621 |
27 | TTK | 1.35461623 |
28 | CSNK1G1 | 1.34150425 |
29 | FLT3 | 1.32685882 |
30 | ARAF | 1.30534925 |
31 | EIF2AK1 | 1.26608012 |
32 | NME2 | 1.19300441 |
33 | OXSR1 | 1.17652323 |
34 | VRK1 | 1.16886404 |
35 | TXK | 1.12118283 |
36 | BRSK1 | 1.09057878 |
37 | EPHB2 | 1.05177667 |
38 | RIPK1 | 1.05165598 |
39 | CSNK1G3 | 1.04385973 |
40 | OBSCN | 1.04086099 |
41 | KIT | 1.03945404 |
42 | BCKDK | 1.02352367 |
43 | STK39 | 1.00765734 |
44 | TAF1 | 0.97993468 |
45 | PNCK | 0.97404562 |
46 | NUAK1 | 0.96065014 |
47 | BMPR2 | 0.94524770 |
48 | PLK3 | 0.90020088 |
49 | EIF2AK2 | 0.89752595 |
50 | DYRK2 | 0.88193369 |
51 | BCR | 0.86389579 |
52 | CSF1R | 0.80808408 |
53 | BMPR1B | 0.76811853 |
54 | ATR | 0.75134167 |
55 | MAP3K12 | 0.74320068 |
56 | MAP3K14 | 0.73265744 |
57 | PLK4 | 0.71430026 |
58 | ACVR1B | 0.70690751 |
59 | PHKG2 | 0.70356696 |
60 | PHKG1 | 0.70356696 |
61 | KDR | 0.69980010 |
62 | NEK6 | 0.67337084 |
63 | CDK7 | 0.66981163 |
64 | AURKB | 0.65935718 |
65 | CLK1 | 0.64236772 |
66 | PRKCI | 0.63236579 |
67 | ERBB3 | 0.59439013 |
68 | ERBB2 | 0.57204748 |
69 | CSNK1G2 | 0.55346893 |
70 | MUSK | 0.53087545 |
71 | CSNK2A2 | 0.51834324 |
72 | CSNK1A1L | 0.51702970 |
73 | FGFR1 | 0.50607874 |
74 | ALK | 0.50335637 |
75 | LRRK2 | 0.48550167 |
76 | TGFBR1 | 0.47224562 |
77 | IGF1R | 0.45227066 |
78 | DAPK1 | 0.44577487 |
79 | PLK2 | 0.43320124 |
80 | SCYL2 | 0.42402586 |
81 | RAF1 | 0.40665066 |
82 | ATM | 0.40568507 |
83 | PRKCG | 0.38672345 |
84 | MYLK | 0.38536206 |
85 | FGFR2 | 0.38358035 |
86 | RPS6KA5 | 0.37368443 |
87 | CSNK2A1 | 0.36924755 |
88 | STK4 | 0.34233514 |
89 | YES1 | 0.31777997 |
90 | FRK | 0.31478596 |
91 | MAP3K9 | 0.30944038 |
92 | STK3 | 0.29480881 |
93 | RPS6KB2 | 0.28825735 |
94 | MAP3K4 | 0.28817162 |
95 | JAK3 | 0.28341694 |
96 | EGFR | 0.28151711 |
97 | RPS6KA4 | 0.27054434 |
98 | CDK1 | 0.26753782 |
99 | MAPKAPK5 | 0.25754953 |
100 | MAPK7 | 0.24495806 |
Rank | Gene Set | Z-score |
---|---|---|
1 | DNA replication_Homo sapiens_hsa03030 | 3.78387671 |
2 | Proteasome_Homo sapiens_hsa03050 | 3.71475461 |
3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.58871298 |
4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.58575091 |
5 | Mismatch repair_Homo sapiens_hsa03430 | 3.54180332 |
6 | Ribosome_Homo sapiens_hsa03010 | 3.33893353 |
7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.98810159 |
8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.54549598 |
9 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.36856395 |
10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.21523461 |
11 | Protein export_Homo sapiens_hsa03060 | 2.19568673 |
12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.18423842 |
13 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.17023086 |
14 | RNA polymerase_Homo sapiens_hsa03020 | 2.16646581 |
15 | Homologous recombination_Homo sapiens_hsa03440 | 2.11421926 |
16 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.06762036 |
17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.06613600 |
18 | Alzheimers disease_Homo sapiens_hsa05010 | 2.02543479 |
19 | Taste transduction_Homo sapiens_hsa04742 | 2.01783383 |
20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.99989443 |
21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.98324252 |
22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.81913951 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.73288126 |
24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.57611221 |
25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.55298275 |
26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.50729092 |
27 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.42127285 |
28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.39570477 |
29 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.38563398 |
30 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.38467934 |
31 | RNA transport_Homo sapiens_hsa03013 | 1.37232717 |
32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.35658729 |
33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.35169001 |
34 | RNA degradation_Homo sapiens_hsa03018 | 1.33525961 |
35 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.30494844 |
36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.25735192 |
37 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.11862278 |
38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.09909892 |
39 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.08303718 |
40 | Purine metabolism_Homo sapiens_hsa00230 | 1.06757043 |
41 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.04005688 |
42 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.00047288 |
43 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.97320842 |
44 | Spliceosome_Homo sapiens_hsa03040 | 0.96977401 |
45 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.93661691 |
46 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.92828635 |
47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.90803551 |
48 | Peroxisome_Homo sapiens_hsa04146 | 0.89833630 |
49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88971519 |
50 | Cell cycle_Homo sapiens_hsa04110 | 0.81022012 |
51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79122223 |
52 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.77756914 |
53 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.77737389 |
54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.76417789 |
55 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.72764006 |
56 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.71191019 |
57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.68546596 |
58 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.67245021 |
59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.66553134 |
60 | Circadian rhythm_Homo sapiens_hsa04710 | 0.65531862 |
61 | Asthma_Homo sapiens_hsa05310 | 0.62411103 |
62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.62327160 |
63 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60227532 |
64 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.54248607 |
65 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.52658887 |
66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.50027028 |
67 | Mineral absorption_Homo sapiens_hsa04978 | 0.49716603 |
68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47464838 |
69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40296822 |
70 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.39997166 |
71 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.36287062 |
72 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34446399 |
73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.33098872 |
74 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.29900832 |
75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.29450236 |
76 | Nicotine addiction_Homo sapiens_hsa05033 | 0.28254737 |
77 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28188714 |
78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.25799428 |
79 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.24816789 |
80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.24595557 |
81 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.23878203 |
82 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.23802966 |
83 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.23505480 |
84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.22533031 |
85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.22404947 |
86 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.21322333 |
87 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.20399436 |
88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.19170339 |
89 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.17945148 |
90 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.17360241 |
91 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.16932333 |
92 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.14388878 |
93 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.12842103 |
94 | Salivary secretion_Homo sapiens_hsa04970 | 0.12227975 |
95 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.12018592 |
96 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.11651174 |
97 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.09670889 |
98 | Lysine degradation_Homo sapiens_hsa00310 | 0.07741239 |
99 | Oocyte meiosis_Homo sapiens_hsa04114 | -0.0101212 |
100 | Glutamatergic synapse_Homo sapiens_hsa04724 | -0.0077500 |