RSL24D1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.91019550
2sexual reproduction (GO:0019953)7.14189778
3establishment of protein localization to mitochondrial membrane (GO:0090151)6.29328388
4serotonin receptor signaling pathway (GO:0007210)6.09118470
5chaperone-mediated protein transport (GO:0072321)5.19300419
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.18035235
7protein neddylation (GO:0045116)5.09684135
8DNA ligation (GO:0006266)4.96248568
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.79855895
10ATP synthesis coupled proton transport (GO:0015986)4.79855895
11GDP-mannose metabolic process (GO:0019673)4.50936616
12DNA strand renaturation (GO:0000733)4.31016034
13inner mitochondrial membrane organization (GO:0007007)4.16673437
14glyoxylate metabolic process (GO:0046487)4.07228087
15intraciliary transport (GO:0042073)4.05670038
16DNA topological change (GO:0006265)4.04861392
17CENP-A containing nucleosome assembly (GO:0034080)3.96965111
18telomere maintenance via semi-conservative replication (GO:0032201)3.96701196
19establishment of integrated proviral latency (GO:0075713)3.95619662
20viral mRNA export from host cell nucleus (GO:0046784)3.85529948
21chromatin remodeling at centromere (GO:0031055)3.85245170
22folic acid metabolic process (GO:0046655)3.83330691
23GTP biosynthetic process (GO:0006183)3.74928693
24UTP metabolic process (GO:0046051)3.70264380
25negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.66307208
26oxaloacetate metabolic process (GO:0006107)3.64044715
27nucleobase-containing small molecule interconversion (GO:0015949)3.63482485
28folic acid transport (GO:0015884)3.54019488
29DNA deamination (GO:0045006)3.52328771
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.52133330
31ribosomal large subunit biogenesis (GO:0042273)3.48943299
32UTP biosynthetic process (GO:0006228)3.47661464
33DNA strand elongation involved in DNA replication (GO:0006271)3.42432080
34artery smooth muscle contraction (GO:0014824)3.41459500
35maturation of 5.8S rRNA (GO:0000460)3.37973323
36transcription-coupled nucleotide-excision repair (GO:0006283)3.34058396
37respiratory electron transport chain (GO:0022904)3.29530691
38response to nitrosative stress (GO:0051409)3.28712020
39negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.27384561
40electron transport chain (GO:0022900)3.25074346
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24981268
42ribonucleoprotein complex disassembly (GO:0032988)3.23477819
43intracellular protein transmembrane import (GO:0044743)3.20204339
44nucleotide-sugar biosynthetic process (GO:0009226)3.18630963
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16298800
46DNA strand elongation (GO:0022616)3.14926484
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.13684948
48purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.11869292
49folic acid-containing compound biosynthetic process (GO:0009396)3.11844576
50replication fork processing (GO:0031297)3.11699443
51pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.10472284
52telomere maintenance via recombination (GO:0000722)3.09848703
53regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.09394526
54synapsis (GO:0007129)3.07310516
55CTP metabolic process (GO:0046036)3.06730375
56CTP biosynthetic process (GO:0006241)3.06730375
57microtubule depolymerization (GO:0007019)3.06175612
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05255991
59pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.03212388
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01371221
61viral transcription (GO:0019083)2.99192886
62drug transport (GO:0015893)2.98516262
63DNA catabolic process, exonucleolytic (GO:0000738)2.97321444
64translational termination (GO:0006415)2.97048008
65lipid particle organization (GO:0034389)2.96025168
66prenylation (GO:0097354)2.96005864
67protein prenylation (GO:0018342)2.96005864
68histone exchange (GO:0043486)2.95263308
69guanosine-containing compound biosynthetic process (GO:1901070)2.95225313
70vascular smooth muscle contraction (GO:0014829)2.94347384
71pyrimidine nucleoside biosynthetic process (GO:0046134)2.94178158
72respiratory chain complex IV assembly (GO:0008535)2.93529078
73pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92745482
74organelle disassembly (GO:1903008)2.92390272
75ribosomal small subunit assembly (GO:0000028)2.92105879
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91793370
77termination of RNA polymerase III transcription (GO:0006386)2.91548053
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.91548053
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91507677
80transcription from RNA polymerase I promoter (GO:0006360)2.91370757
81pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90826172
82negative regulation of signal transduction by p53 class mediator (GO:1901797)2.89858946
83non-recombinational repair (GO:0000726)2.89392644
84double-strand break repair via nonhomologous end joining (GO:0006303)2.89392644
85regulation of DNA endoreduplication (GO:0032875)2.87819317
86pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.87712637
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87111183
88cotranslational protein targeting to membrane (GO:0006613)2.86157943
89indole-containing compound catabolic process (GO:0042436)2.85910373
90indolalkylamine catabolic process (GO:0046218)2.85910373
91tryptophan catabolic process (GO:0006569)2.85910373
92protein targeting to ER (GO:0045047)2.85865775
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85411676
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84985559
95phasic smooth muscle contraction (GO:0014821)2.84749939
96pteridine-containing compound biosynthetic process (GO:0042559)2.83251914
97deoxyribonucleotide biosynthetic process (GO:0009263)2.82685273
98tonic smooth muscle contraction (GO:0014820)2.82680681
99ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82219426
100mitotic recombination (GO:0006312)2.80484460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54790292
2VDR_22108803_ChIP-Seq_LS180_Human4.92085801
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27977468
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.71247839
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.62649170
6IGF1R_20145208_ChIP-Seq_DFB_Human3.31221751
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.29903075
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.23307507
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93178634
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87025289
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81957822
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47072615
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40327612
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.38780856
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34739848
16VDR_23849224_ChIP-Seq_CD4+_Human2.33060988
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29067577
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26303081
19TAF15_26573619_Chip-Seq_HEK293_Human2.22279944
20ELK1_19687146_ChIP-ChIP_HELA_Human2.20850971
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.15378643
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14081700
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12521612
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09647951
25FUS_26573619_Chip-Seq_HEK293_Human1.98338833
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94311044
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91052832
28FOXP3_21729870_ChIP-Seq_TREG_Human1.88455451
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88002975
30AR_21909140_ChIP-Seq_LNCAP_Human1.83573680
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.81852687
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.79558301
33ZNF274_21170338_ChIP-Seq_K562_Hela1.77719755
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74155850
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71051850
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66771321
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66026575
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65354447
39MYC_18940864_ChIP-ChIP_HL60_Human1.65318594
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63075131
41EWS_26573619_Chip-Seq_HEK293_Human1.60132256
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58603671
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57500534
44DCP1A_22483619_ChIP-Seq_HELA_Human1.55018299
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.53493267
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49540924
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49256684
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42431748
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42003191
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41846360
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34020173
52IRF1_19129219_ChIP-ChIP_H3396_Human1.33538274
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30422366
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26195842
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25516652
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.23150249
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23150249
58GABP_19822575_ChIP-Seq_HepG2_Human1.22778773
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22710839
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22046810
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20819075
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20754779
63P300_19829295_ChIP-Seq_ESCs_Human1.19564557
64TTF2_22483619_ChIP-Seq_HELA_Human1.17744862
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17102689
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16491094
67XRN2_22483619_ChIP-Seq_HELA_Human1.12183831
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10958163
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10906227
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09269031
71JUN_21703547_ChIP-Seq_K562_Human1.08446003
72ERG_20517297_ChIP-Seq_VCAP_Human1.08154459
73HTT_18923047_ChIP-ChIP_STHdh_Human1.08148034
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07986713
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.02652867
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01646354
77SALL4_22934838_ChIP-ChIP_CD34+_Human0.97868435
78NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95314467
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95047919
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93898991
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.93524015
82THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91645717
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88191199
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87633584
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.87214007
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86931588
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.86924052
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85732465
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84143691
90SMAD4_21799915_ChIP-Seq_A2780_Human0.84142274
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83122366
92AR_25329375_ChIP-Seq_VCAP_Human0.83052345
93ER_23166858_ChIP-Seq_MCF-7_Human0.81513448
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80673873
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80220722
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79823000
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79775164
98NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79678600
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.78614471
100NANOG_19829295_ChIP-Seq_ESCs_Human0.78238344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.01653955
2MP0009780_abnormal_chondrocyte_physiolo5.30523176
3MP0009379_abnormal_foot_pigmentation4.12360383
4MP0005171_absent_coat_pigmentation4.00978108
5MP0003183_abnormal_peptide_metabolism3.78811609
6MP0002938_white_spotting3.68306442
7MP0010094_abnormal_chromosome_stability3.41361655
8MP0005360_urolithiasis3.17908356
9MP0005075_abnormal_melanosome_morpholog3.06408685
10MP0002837_dystrophic_cardiac_calcinosis2.94925862
11MP0008058_abnormal_DNA_repair2.91896916
12MP0003136_yellow_coat_color2.57255751
13MP0002736_abnormal_nociception_after2.49185883
14MP0008260_abnormal_autophagy2.37398602
15MP0008057_abnormal_DNA_replication2.31790342
16MP0005248_abnormal_Harderian_gland2.12480059
17MP0004147_increased_porphyrin_level2.10865359
18MP0000383_abnormal_hair_follicle1.80345317
19MP0010678_abnormal_skin_adnexa1.71761539
20MP0000015_abnormal_ear_pigmentation1.71565213
21MP0003011_delayed_dark_adaptation1.71472434
22MP0008789_abnormal_olfactory_epithelium1.66558540
23MP0005408_hypopigmentation1.59313759
24MP0005084_abnormal_gallbladder_morpholo1.56559888
25MP0005409_darkened_coat_color1.54956898
26MP0006292_abnormal_olfactory_placode1.54898306
27MP0005174_abnormal_tail_pigmentation1.51738668
28MP0000013_abnormal_adipose_tissue1.44952951
29MP0001293_anophthalmia1.42560668
30MP0003195_calcinosis1.36746279
31MP0008875_abnormal_xenobiotic_pharmacok1.33319372
32MP0002234_abnormal_pharynx_morphology1.26077958
33MP0001968_abnormal_touch/_nociception1.25476539
34MP0003186_abnormal_redox_activity1.24166851
35MP0003122_maternal_imprinting1.22704962
36MP0001529_abnormal_vocalization1.18129068
37MP0008007_abnormal_cellular_replicative1.17440488
38MP0005083_abnormal_biliary_tract1.17375075
39MP0003656_abnormal_erythrocyte_physiolo1.16538385
40MP0002163_abnormal_gland_morphology1.13855815
41MP0002233_abnormal_nose_morphology1.12902770
42MP0006072_abnormal_retinal_apoptosis1.11048578
43MP0001188_hyperpigmentation1.08930037
44MP0000428_abnormal_craniofacial_morphol1.08051568
45MP0002396_abnormal_hematopoietic_system1.05972773
46MP0002638_abnormal_pupillary_reflex1.05150812
47MP0006276_abnormal_autonomic_nervous1.04816347
48MP0005394_taste/olfaction_phenotype1.03437859
49MP0005499_abnormal_olfactory_system1.03437859
50MP0002132_abnormal_respiratory_system1.02576833
51MP0001346_abnormal_lacrimal_gland1.02418198
52MP0002139_abnormal_hepatobiliary_system1.01701387
53MP0005636_abnormal_mineral_homeostasis1.00762014
54MP0002095_abnormal_skin_pigmentation1.00376613
55MP0001324_abnormal_eye_pigmentation0.97965969
56MP0002075_abnormal_coat/hair_pigmentati0.96688297
57MP0003718_maternal_effect0.92335899
58MP0003786_premature_aging0.92032862
59MP0001764_abnormal_homeostasis0.89691247
60MP0002127_abnormal_cardiovascular_syste0.89617968
61MP0004957_abnormal_blastocyst_morpholog0.89352201
62MP0003950_abnormal_plasma_membrane0.85319471
63MP0005645_abnormal_hypothalamus_physiol0.84814779
64MP0005551_abnormal_eye_electrophysiolog0.84791053
65MP0003937_abnormal_limbs/digits/tail_de0.84422530
66MP0005332_abnormal_amino_acid0.84158689
67MP0003878_abnormal_ear_physiology0.83420271
68MP0005377_hearing/vestibular/ear_phenot0.83420271
69MP0006035_abnormal_mitochondrial_morpho0.82464135
70MP0006036_abnormal_mitochondrial_physio0.80655746
71MP0002751_abnormal_autonomic_nervous0.80147170
72MP0008873_increased_physiological_sensi0.80126943
73MP0003077_abnormal_cell_cycle0.75435992
74MP0002971_abnormal_brown_adipose0.74432153
75MP0002876_abnormal_thyroid_physiology0.73691340
76MP0010234_abnormal_vibrissa_follicle0.73137714
77MP0001186_pigmentation_phenotype0.73047462
78MP0001243_abnormal_dermal_layer0.72737866
79MP0008932_abnormal_embryonic_tissue0.72513258
80MP0009697_abnormal_copulation0.71860545
81MP0000427_abnormal_hair_cycle0.69093815
82MP0003121_genomic_imprinting0.68776402
83MP0002697_abnormal_eye_size0.67767798
84MP0000631_abnormal_neuroendocrine_gland0.66248812
85MP0005379_endocrine/exocrine_gland_phen0.66007166
86MP0003252_abnormal_bile_duct0.64981236
87MP0002896_abnormal_bone_mineralization0.64365458
88MP0000003_abnormal_adipose_tissue0.63583279
89MP0003880_abnormal_central_pattern0.63222051
90MP0000647_abnormal_sebaceous_gland0.62232199
91MP0003283_abnormal_digestive_organ0.62079852
92MP0003868_abnormal_feces_composition0.61077684
93MP0004215_abnormal_myocardial_fiber0.60728859
94MP0004134_abnormal_chest_morphology0.60364018
95MP0001881_abnormal_mammary_gland0.59791878
96MP0008995_early_reproductive_senescence0.59500570
97MP0000579_abnormal_nail_morphology0.59374949
98MP0010030_abnormal_orbit_morphology0.58189735
99MP0003942_abnormal_urinary_system0.58100284
100MP0005670_abnormal_white_adipose0.57618021

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.22514318
2Popliteal pterygium (HP:0009756)4.44476283
3Increased hepatocellular lipid droplets (HP:0006565)4.42565359
4Congenital, generalized hypertrichosis (HP:0004540)4.00132389
5Metaphyseal dysplasia (HP:0100255)3.95555538
6Disproportionate short-trunk short stature (HP:0003521)3.93445685
73-Methylglutaconic aciduria (HP:0003535)3.78850169
8Hypoplastic ischia (HP:0003175)3.77041912
9Short tibia (HP:0005736)3.67923595
10Lipid accumulation in hepatocytes (HP:0006561)3.65445660
11Increased serum pyruvate (HP:0003542)3.56408129
12Abnormal number of erythroid precursors (HP:0012131)3.41906901
13Aplasia/Hypoplasia of the tibia (HP:0005772)3.40094757
14Renal Fanconi syndrome (HP:0001994)3.37015471
15Absent/shortened dynein arms (HP:0200106)3.35919583
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.35919583
17Abnormality of the ischium (HP:0003174)3.25785375
18Increased CSF lactate (HP:0002490)3.23756053
19Macrocytic anemia (HP:0001972)3.03192293
20Abnormality of glycolysis (HP:0004366)3.03000234
21Abnormality of cells of the erythroid lineage (HP:0012130)3.02343141
22Hepatocellular necrosis (HP:0001404)2.99423340
23Mitochondrial inheritance (HP:0001427)2.97154734
24Focal motor seizures (HP:0011153)2.95045250
25Choroideremia (HP:0001139)2.93022314
26Hepatic necrosis (HP:0002605)2.91887923
27Type 2 muscle fiber atrophy (HP:0003554)2.87209463
28Abnormal respiratory motile cilium physiology (HP:0012261)2.79414427
29Microglossia (HP:0000171)2.76393817
30Exertional dyspnea (HP:0002875)2.65160188
31Amniotic constriction ring (HP:0009775)2.62898790
32Abnormality of placental membranes (HP:0011409)2.62898790
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62001270
34Facial hemangioma (HP:0000329)2.55790351
35Acute encephalopathy (HP:0006846)2.52013768
36Microvesicular hepatic steatosis (HP:0001414)2.51369872
37Abnormal foot bone ossification (HP:0010675)2.47554108
38Abnormal ciliary motility (HP:0012262)2.46191011
39Abnormality of renal resorption (HP:0011038)2.45959292
40Fibular hypoplasia (HP:0003038)2.45600423
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.43207211
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41207558
43Respiratory difficulties (HP:0002880)2.39890850
44Barrel-shaped chest (HP:0001552)2.39634726
45Absent epiphyses (HP:0010577)2.39507963
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.39507963
47Poor head control (HP:0002421)2.37915538
48Volvulus (HP:0002580)2.36579266
49Acute necrotizing encephalopathy (HP:0006965)2.36024502
50Increased nuchal translucency (HP:0010880)2.30759128
51Abnormality of midbrain morphology (HP:0002418)2.30315402
52Molar tooth sign on MRI (HP:0002419)2.30315402
53Duplicated collecting system (HP:0000081)2.30074632
54Alacrima (HP:0000522)2.29399584
55Muscle fiber atrophy (HP:0100295)2.28967243
56Increased serum lactate (HP:0002151)2.28068943
57Retinal dysplasia (HP:0007973)2.26000207
58Hyperglycinemia (HP:0002154)2.21511129
59Decreased lacrimation (HP:0000633)2.21245256
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.21054045
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20644255
62Hypoplasia of the radius (HP:0002984)2.19515830
63Proximal tubulopathy (HP:0000114)2.18149082
64Pterygium (HP:0001059)2.14126170
65Bell-shaped thorax (HP:0001591)2.13879467
66Abnormal respiratory epithelium morphology (HP:0012253)2.13589745
67Abnormal respiratory motile cilium morphology (HP:0005938)2.13589745
68Glycosuria (HP:0003076)2.12142701
69Abnormality of urine glucose concentration (HP:0011016)2.12142701
70Increased intramyocellular lipid droplets (HP:0012240)2.09935771
71Abnormality of DNA repair (HP:0003254)2.09932854
72Pulmonary artery stenosis (HP:0004415)2.08956666
73Lactic acidosis (HP:0003128)2.08708195
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07410528
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07410528
76Megaloblastic anemia (HP:0001889)2.07297274
77Pallor (HP:0000980)2.06899973
78Hyperphosphaturia (HP:0003109)2.06088973
79Patchy hypopigmentation of hair (HP:0011365)2.05152441
80Abnormality of the renal collecting system (HP:0004742)2.03935977
81Hypoplasia of the pons (HP:0012110)2.02479651
82Facial diplegia (HP:0001349)2.00964088
83Increased corneal curvature (HP:0100692)1.97268598
84Keratoconus (HP:0000563)1.97268598
85Abnormality of cochlea (HP:0000375)1.95387385
86Prolonged partial thromboplastin time (HP:0003645)1.94740733
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94529962
88Progressive macrocephaly (HP:0004481)1.93952673
89Abnormality of the anterior horn cell (HP:0006802)1.93531063
90Degeneration of anterior horn cells (HP:0002398)1.93531063
91Constricted visual fields (HP:0001133)1.91413700
92Bifid tongue (HP:0010297)1.91045408
93Generalized aminoaciduria (HP:0002909)1.90778934
94Abnormal mitochondria in muscle tissue (HP:0008316)1.87018472
95Testicular atrophy (HP:0000029)1.86344087
96Depressed nasal tip (HP:0000437)1.86122488
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85216251
98Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83235381
99Epidermoid cyst (HP:0200040)1.81015421
100Pancytopenia (HP:0001876)1.77816112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME14.11356806
2CASK3.55500398
3CDK83.48023780
4MAP4K23.37636940
5BRD43.04252456
6CCNB13.01479149
7ZAK2.80299490
8STK162.67117171
9NTRK32.39560045
10MST42.26082365
11NEK12.06213986
12CDK192.06014084
13BUB11.89500099
14MAP3K101.85163350
15WEE11.82592706
16TLK11.79954977
17PINK11.78295087
18VRK21.73352159
19MKNK21.70296548
20MKNK11.65517930
21EIF2AK31.61264578
22CDC71.60013940
23MAPKAPK31.56901045
24WNK31.53547355
25WNK41.52714506
26BRSK21.40141621
27TTK1.35461623
28CSNK1G11.34150425
29FLT31.32685882
30ARAF1.30534925
31EIF2AK11.26608012
32NME21.19300441
33OXSR11.17652323
34VRK11.16886404
35TXK1.12118283
36BRSK11.09057878
37EPHB21.05177667
38RIPK11.05165598
39CSNK1G31.04385973
40OBSCN1.04086099
41KIT1.03945404
42BCKDK1.02352367
43STK391.00765734
44TAF10.97993468
45PNCK0.97404562
46NUAK10.96065014
47BMPR20.94524770
48PLK30.90020088
49EIF2AK20.89752595
50DYRK20.88193369
51BCR0.86389579
52CSF1R0.80808408
53BMPR1B0.76811853
54ATR0.75134167
55MAP3K120.74320068
56MAP3K140.73265744
57PLK40.71430026
58ACVR1B0.70690751
59PHKG20.70356696
60PHKG10.70356696
61KDR0.69980010
62NEK60.67337084
63CDK70.66981163
64AURKB0.65935718
65CLK10.64236772
66PRKCI0.63236579
67ERBB30.59439013
68ERBB20.57204748
69CSNK1G20.55346893
70MUSK0.53087545
71CSNK2A20.51834324
72CSNK1A1L0.51702970
73FGFR10.50607874
74ALK0.50335637
75LRRK20.48550167
76TGFBR10.47224562
77IGF1R0.45227066
78DAPK10.44577487
79PLK20.43320124
80SCYL20.42402586
81RAF10.40665066
82ATM0.40568507
83PRKCG0.38672345
84MYLK0.38536206
85FGFR20.38358035
86RPS6KA50.37368443
87CSNK2A10.36924755
88STK40.34233514
89YES10.31777997
90FRK0.31478596
91MAP3K90.30944038
92STK30.29480881
93RPS6KB20.28825735
94MAP3K40.28817162
95JAK30.28341694
96EGFR0.28151711
97RPS6KA40.27054434
98CDK10.26753782
99MAPKAPK50.25754953
100MAPK70.24495806

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.78387671
2Proteasome_Homo sapiens_hsa030503.71475461
3Oxidative phosphorylation_Homo sapiens_hsa001903.58871298
4Non-homologous end-joining_Homo sapiens_hsa034503.58575091
5Mismatch repair_Homo sapiens_hsa034303.54180332
6Ribosome_Homo sapiens_hsa030103.33893353
7Parkinsons disease_Homo sapiens_hsa050122.98810159
8Nucleotide excision repair_Homo sapiens_hsa034202.54549598
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36856395
10One carbon pool by folate_Homo sapiens_hsa006702.21523461
11Protein export_Homo sapiens_hsa030602.19568673
12Huntingtons disease_Homo sapiens_hsa050162.18423842
13Fatty acid elongation_Homo sapiens_hsa000622.17023086
14RNA polymerase_Homo sapiens_hsa030202.16646581
15Homologous recombination_Homo sapiens_hsa034402.11421926
16Steroid biosynthesis_Homo sapiens_hsa001002.06762036
17Cardiac muscle contraction_Homo sapiens_hsa042602.06613600
18Alzheimers disease_Homo sapiens_hsa050102.02543479
19Taste transduction_Homo sapiens_hsa047422.01783383
20Basal transcription factors_Homo sapiens_hsa030221.99989443
21Propanoate metabolism_Homo sapiens_hsa006401.98324252
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81913951
23Base excision repair_Homo sapiens_hsa034101.73288126
24Pyrimidine metabolism_Homo sapiens_hsa002401.57611221
25Fanconi anemia pathway_Homo sapiens_hsa034601.55298275
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50729092
27Vitamin digestion and absorption_Homo sapiens_hsa049771.42127285
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39570477
29Fatty acid metabolism_Homo sapiens_hsa012121.38563398
30Pyruvate metabolism_Homo sapiens_hsa006201.38467934
31RNA transport_Homo sapiens_hsa030131.37232717
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35658729
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35169001
34RNA degradation_Homo sapiens_hsa030181.33525961
35Folate biosynthesis_Homo sapiens_hsa007901.30494844
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25735192
37Tryptophan metabolism_Homo sapiens_hsa003801.11862278
38Butanoate metabolism_Homo sapiens_hsa006501.09909892
39Glutathione metabolism_Homo sapiens_hsa004801.08303718
40Purine metabolism_Homo sapiens_hsa002301.06757043
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04005688
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00047288
43Fatty acid degradation_Homo sapiens_hsa000710.97320842
44Spliceosome_Homo sapiens_hsa030400.96977401
45Serotonergic synapse_Homo sapiens_hsa047260.93661691
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92828635
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90803551
48Peroxisome_Homo sapiens_hsa041460.89833630
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88971519
50Cell cycle_Homo sapiens_hsa041100.81022012
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79122223
52Fructose and mannose metabolism_Homo sapiens_hsa000510.77756914
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77737389
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76417789
55Sulfur metabolism_Homo sapiens_hsa009200.72764006
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71191019
57Caffeine metabolism_Homo sapiens_hsa002320.68546596
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67245021
59Retinol metabolism_Homo sapiens_hsa008300.66553134
60Circadian rhythm_Homo sapiens_hsa047100.65531862
61Asthma_Homo sapiens_hsa053100.62411103
62Metabolic pathways_Homo sapiens_hsa011000.62327160
63Carbon metabolism_Homo sapiens_hsa012000.60227532
64Vitamin B6 metabolism_Homo sapiens_hsa007500.54248607
65p53 signaling pathway_Homo sapiens_hsa041150.52658887
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50027028
67Mineral absorption_Homo sapiens_hsa049780.49716603
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47464838
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40296822
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39997166
71Fatty acid biosynthesis_Homo sapiens_hsa000610.36287062
72Biosynthesis of amino acids_Homo sapiens_hsa012300.34446399
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33098872
74Nitrogen metabolism_Homo sapiens_hsa009100.29900832
75Ether lipid metabolism_Homo sapiens_hsa005650.29450236
76Nicotine addiction_Homo sapiens_hsa050330.28254737
77Regulation of autophagy_Homo sapiens_hsa041400.28188714
78Olfactory transduction_Homo sapiens_hsa047400.25799428
79Basal cell carcinoma_Homo sapiens_hsa052170.24816789
80Arginine and proline metabolism_Homo sapiens_hsa003300.24595557
81Antigen processing and presentation_Homo sapiens_hsa046120.23878203
82Chemical carcinogenesis_Homo sapiens_hsa052040.23802966
83Type I diabetes mellitus_Homo sapiens_hsa049400.23505480
84Linoleic acid metabolism_Homo sapiens_hsa005910.22533031
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22404947
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21322333
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.20399436
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.19170339
89mRNA surveillance pathway_Homo sapiens_hsa030150.17945148
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17360241
91Thyroid hormone synthesis_Homo sapiens_hsa049180.16932333
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14388878
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12842103
94Salivary secretion_Homo sapiens_hsa049700.12227975
95cAMP signaling pathway_Homo sapiens_hsa040240.12018592
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.11651174
97African trypanosomiasis_Homo sapiens_hsa051430.09670889
98Lysine degradation_Homo sapiens_hsa003100.07741239
99Oocyte meiosis_Homo sapiens_hsa04114-0.0101212
100Glutamatergic synapse_Homo sapiens_hsa04724-0.0077500

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