ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.55345774
2	cytidine metabolic process (GO:0046087)	6.53360754
3	cytidine catabolic process (GO:0006216)	6.53360754
4	cytidine deamination (GO:0009972)	6.53360754
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.26150552
6	DNA deamination (GO:0045006)	5.95191903
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.19364905
8	actin nucleation (GO:0045010)	4.82963020
9	negative regulation of T cell apoptotic process (GO:0070233)	4.67546207
10	DNA double-strand break processing (GO:0000729)	4.53735287
11	regulation of regulatory T cell differentiation (GO:0045589)	4.28423203
12	positive regulation of tolerance induction (GO:0002645)	4.23089676
13	positive T cell selection (GO:0043368)	4.22884577
14	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	4.21433538
15	negative regulation by host of viral transcription (GO:0043922)	4.17072484
16	S-adenosylmethionine metabolic process (GO:0046500)	3.90049853
17	sequestering of actin monomers (GO:0042989)	3.81988937
18	labyrinthine layer development (GO:0060711)	3.73545994
19	regulation of T cell tolerance induction (GO:0002664)	3.63942398
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62737500
21	DNA demethylation (GO:0080111)	3.61860316
22	positive regulation of B cell differentiation (GO:0045579)	3.45731111
23	mannosylation (GO:0097502)	3.39438935
24	regulation of isotype switching to IgG isotypes (GO:0048302)	3.33457862
25	regulation of interleukin-2 biosynthetic process (GO:0045076)	3.32652128
26	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.31135227
27	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.31135227
28	response to nitric oxide (GO:0071731)	3.29915673
29	positive regulation of interleukin-4 production (GO:0032753)	3.27534409
30	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.23586301
31	sulfation (GO:0051923)	3.23076669
32	left/right axis specification (GO:0070986)	3.22855706
33	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.21262883
34	autophagic vacuole fusion (GO:0000046)	3.20189266
35	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.16151257
36	cytolysis (GO:0019835)	3.15280163
37	positive regulation of calcium-mediated signaling (GO:0050850)	3.10155968
38	negative regulation of thymocyte apoptotic process (GO:0070244)	3.05931606
39	positive regulation of lamellipodium assembly (GO:0010592)	3.05911405
40	regulation of T cell chemotaxis (GO:0010819)	3.04514577
41	positive regulation of T cell chemotaxis (GO:0010820)	3.04514577
42	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.03557051
43	mRNA modification (GO:0016556)	3.01467706
44	regulation of tolerance induction (GO:0002643)	3.01034173
45	DNA dealkylation (GO:0035510)	3.00695873
46	pyrimidine nucleoside catabolic process (GO:0046135)	2.97981911
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97716399
48	negative regulation of DNA recombination (GO:0045910)	2.93494647
49	protein neddylation (GO:0045116)	2.93416542
50	axoneme assembly (GO:0035082)	2.92211265
51	positive regulation of gamma-delta T cell activation (GO:0046645)	2.91547273
52	negative T cell selection (GO:0043383)	2.88576685
53	positive thymic T cell selection (GO:0045059)	2.88409126
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85674227
55	positive regulation of protein homodimerization activity (GO:0090073)	2.80236276
56	amino acid salvage (GO:0043102)	2.75966138
57	L-methionine salvage (GO:0071267)	2.75966138
58	L-methionine biosynthetic process (GO:0071265)	2.75966138
59	response to UV-C (GO:0010225)	2.75061605
60	T cell selection (GO:0045058)	2.74708698
61	centriole replication (GO:0007099)	2.72764299
62	response to pheromone (GO:0019236)	2.71201910
63	platelet dense granule organization (GO:0060155)	2.68904354
64	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.68247921
65	synaptonemal complex organization (GO:0070193)	2.68030592
66	positive regulation of T cell differentiation in thymus (GO:0033089)	2.67420102
67	neuron remodeling (GO:0016322)	2.66339748
68	synaptonemal complex assembly (GO:0007130)	2.66018700
69	regulation of B cell differentiation (GO:0045577)	2.63673628
70	regulation of penile erection (GO:0060405)	2.61934633
71	regulation of alpha-beta T cell proliferation (GO:0046640)	2.61038247
72	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.57940219
73	regulation of lymphocyte chemotaxis (GO:1901623)	2.55342858
74	regulation of T cell apoptotic process (GO:0070232)	2.54606907
75	regulation of uterine smooth muscle contraction (GO:0070472)	2.54034849
76	T cell migration (GO:0072678)	2.53814540
77	positive regulation of defense response to virus by host (GO:0002230)	2.52689318
78	regulation of gamma-delta T cell differentiation (GO:0045586)	2.50332610
79	drug transmembrane transport (GO:0006855)	2.49626294
80	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.49521346
81	macrophage chemotaxis (GO:0048246)	2.47961162
82	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.47357511
83	negative thymic T cell selection (GO:0045060)	2.47313404
84	negative regulation of viral genome replication (GO:0045071)	2.46573116
85	T cell receptor signaling pathway (GO:0050852)	2.46252853
86	proteasome assembly (GO:0043248)	2.46108206
87	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.45120621
88	regulation of calcium-mediated signaling (GO:0050848)	2.45119600
89	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.43053205
90	thymic T cell selection (GO:0045061)	2.43031812
91	centriole assembly (GO:0098534)	2.42848213
92	T cell costimulation (GO:0031295)	2.42656692
93	positive regulation of digestive system process (GO:0060456)	2.42398796
94	cellular response to antibiotic (GO:0071236)	2.40223585
95	lymphocyte costimulation (GO:0031294)	2.39646285
96	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.38637562
97	regulation of T cell receptor signaling pathway (GO:0050856)	2.37625181
98	indole-containing compound catabolic process (GO:0042436)	2.33014673
99	indolalkylamine catabolic process (GO:0046218)	2.33014673
100	tryptophan catabolic process (GO:0006569)	2.33014673

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.62652719
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.03474710
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32482850
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.89451797
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69275563
6	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.68565210
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64018025
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.52166391
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.51437887
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.33729101
11	GATA1_22025678_ChIP-Seq_K562_Human	2.18725396
12	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.17281962
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.09013541
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.08895657
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05688765
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.01297430
17	EWS_26573619_Chip-Seq_HEK293_Human	1.98556911
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.97637677
19	MYB_26560356_Chip-Seq_TH2_Human	1.91808693
20	FUS_26573619_Chip-Seq_HEK293_Human	1.89748989
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86154868
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85663421
23	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.84895261
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.77723584
25	P300_19829295_ChIP-Seq_ESCs_Human	1.76782358
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76660689
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.76144505
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72441279
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.71610543
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65415913
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.64072027
32	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.64018295
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.62504532
34	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.62189857
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.61696761
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61696761
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57228968
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52064123
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50274218
40	GATA3_27048872_Chip-Seq_THYMUS_Human	1.48524036
41	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.47712697
42	VDR_22108803_ChIP-Seq_LS180_Human	1.45107674
43	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.43990438
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42765853
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42765853
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.42584281
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37306630
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.36074333
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.32380392
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31977963
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.31490796
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30039059
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29303379
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.29257879
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29181130
56	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.28947443
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28683933
58	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.28321311
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24838818
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22853366
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22099162
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22044329
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21780340
64	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21731914
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19744983
66	AR_25329375_ChIP-Seq_VCAP_Human	1.19621842
67	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.19456899
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18541955
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18184347
70	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17723715
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17574642
72	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16993326
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16498605
74	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.15403020
75	AR_20517297_ChIP-Seq_VCAP_Human	1.14906355
76	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.14895723
77	P300_18555785_Chip-Seq_ESCs_Mouse	1.14581254
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13798759
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13078893
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12950756
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11850580
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11850580
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.11803652
84	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11787288
85	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11164759
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10402573
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.10251016
88	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09778619
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09333820
90	GATA3_26560356_Chip-Seq_TH2_Human	1.09280429
91	NCOR_22424771_ChIP-Seq_293T_Human	1.09235479
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.08904522
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08605492
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05638875
95	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.05068946
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04970007
97	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03500436
98	MYC_18940864_ChIP-ChIP_HL60_Human	1.03055375
99	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.02407052
100	MYB_26560356_Chip-Seq_TH1_Human	1.01772737

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.52981851
2	MP0002102_abnormal_ear_morphology	4.08554819
3	MP0005671_abnormal_response_to	3.87178886
4	MP0001873_stomach_inflammation	3.35231383
5	MP0002166_altered_tumor_susceptibility	2.96104537
6	MP0001835_abnormal_antigen_presentation	2.85317580
7	MP0002132_abnormal_respiratory_system	2.76537218
8	MP0001188_hyperpigmentation	2.73105788
9	MP0002160_abnormal_reproductive_system	2.62788946
10	MP0009785_altered_susceptibility_to	2.52845331
11	MP0001919_abnormal_reproductive_system	2.38107546
12	MP0005377_hearing/vestibular/ear_phenot	2.34745620
13	MP0003878_abnormal_ear_physiology	2.34745620
14	MP0002006_tumorigenesis	2.20939864
15	MP0005083_abnormal_biliary_tract	2.20191233
16	MP0008877_abnormal_DNA_methylation	2.01927751
17	MP0006072_abnormal_retinal_apoptosis	1.97247006
18	MP0001727_abnormal_embryo_implantation	1.96508795
19	MP0006082_CNS_inflammation	1.89911132
20	MP0001529_abnormal_vocalization	1.85159460
21	MP0004134_abnormal_chest_morphology	1.80949486
22	MP0003763_abnormal_thymus_physiology	1.76940355
23	MP0005389_reproductive_system_phenotype	1.72207910
24	MP0003136_yellow_coat_color	1.69622113
25	MP0009333_abnormal_splenocyte_physiolog	1.66524609
26	MP0005171_absent_coat_pigmentation	1.57413468
27	MP0003045_fibrosis	1.56961671
28	MP0009697_abnormal_copulation	1.56171420
29	MP0002876_abnormal_thyroid_physiology	1.54396697
30	MP0005551_abnormal_eye_electrophysiolog	1.53104399
31	MP0001800_abnormal_humoral_immune	1.52404139
32	MP0008058_abnormal_DNA_repair	1.49797254
33	MP0004142_abnormal_muscle_tone	1.46884653
34	MP0004145_abnormal_muscle_electrophysio	1.45323620
35	MP0008995_early_reproductive_senescence	1.42237471
36	MP0006292_abnormal_olfactory_placode	1.31707079
37	MP0003866_abnormal_defecation	1.28274684
38	MP0005645_abnormal_hypothalamus_physiol	1.27341486
39	MP0002095_abnormal_skin_pigmentation	1.21792620
40	MP0005253_abnormal_eye_physiology	1.17546317
41	MP0003786_premature_aging	1.17357554
42	MP0005084_abnormal_gallbladder_morpholo	1.16482095
43	MP0000372_irregular_coat_pigmentation	1.13911895
44	MP0008789_abnormal_olfactory_epithelium	1.11068998
45	MP0002933_joint_inflammation	1.08728111
46	MP0002420_abnormal_adaptive_immunity	1.08143300
47	MP0005025_abnormal_response_to	1.07497314
48	MP0002398_abnormal_bone_marrow	1.06837064
49	MP0002837_dystrophic_cardiac_calcinosis	1.05952611
50	MP0005075_abnormal_melanosome_morpholog	1.04947521
51	MP0002723_abnormal_immune_serum	1.04249093
52	MP0000689_abnormal_spleen_morphology	1.03329041
53	MP0000716_abnormal_immune_system	1.01235189
54	MP0005000_abnormal_immune_tolerance	0.98146705
55	MP0003137_abnormal_impulse_conducting	0.97658689
56	MP0002405_respiratory_system_inflammati	0.97218179
57	MP0001819_abnormal_immune_cell	0.97216910
58	MP0005085_abnormal_gallbladder_physiolo	0.96357261
59	MP0001299_abnormal_eye_distance/	0.95262106
60	MP0002722_abnormal_immune_system	0.94420323
61	MP0000703_abnormal_thymus_morphology	0.93873401
62	MP0009840_abnormal_foam_cell	0.90886366
63	MP0005360_urolithiasis	0.87049944
64	MP0003806_abnormal_nucleotide_metabolis	0.86560849
65	MP0003221_abnormal_cardiomyocyte_apopto	0.86308635
66	MP0002452_abnormal_antigen_presenting	0.86036441
67	MP0003567_abnormal_fetal_cardiomyocyte	0.83740291
68	MP0002234_abnormal_pharynx_morphology	0.83166828
69	MP0002148_abnormal_hypersensitivity_rea	0.82631082
70	MP0000685_abnormal_immune_system	0.82107411
71	MP0005387_immune_system_phenotype	0.81390951
72	MP0001790_abnormal_immune_system	0.81390951
73	MP0010155_abnormal_intestine_physiology	0.81254093
74	MP0004924_abnormal_behavior	0.79090894
75	MP0005386_behavior/neurological_phenoty	0.79090894
76	MP0003718_maternal_effect	0.78268796
77	MP0008057_abnormal_DNA_replication	0.78227025
78	MP0001293_anophthalmia	0.75840726
79	MP0001119_abnormal_female_reproductive	0.72942776
80	MP0001853_heart_inflammation	0.72446562
81	MP0000631_abnormal_neuroendocrine_gland	0.71812776
82	MP0002090_abnormal_vision	0.71434741
83	MP0001486_abnormal_startle_reflex	0.70244037
84	MP0003787_abnormal_imprinting	0.69979822
85	MP0002429_abnormal_blood_cell	0.68847591
86	MP0009763_increased_sensitivity_to	0.68634318
87	MP0001929_abnormal_gametogenesis	0.68495708
88	MP0002272_abnormal_nervous_system	0.65564759
89	MP0002653_abnormal_ependyma_morphology	0.63708251
90	MP0005391_vision/eye_phenotype	0.63696590
91	MP0003195_calcinosis	0.63678045
92	MP0008770_decreased_survivor_rate	0.63557008
93	MP0001764_abnormal_homeostasis	0.62991488
94	MP0000383_abnormal_hair_follicle	0.62489318
95	MP0001851_eye_inflammation	0.60503565
96	MP0002019_abnormal_tumor_incidence	0.59242819
97	MP0004484_altered_response_of	0.58343895
98	MP0008872_abnormal_physiological_respon	0.58323342
99	MP0004885_abnormal_endolymph	0.58126456
100	MP0003646_muscle_fatigue	0.57595351

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	6.50359143
2	Hypoproteinemia (HP:0003075)	5.69006550
3	Abnormality of B cell number (HP:0010975)	5.60471165
4	T lymphocytopenia (HP:0005403)	5.48481715
5	B lymphocytopenia (HP:0010976)	5.32417969
6	Severe combined immunodeficiency (HP:0004430)	5.21473925
7	Abnormality of T cell number (HP:0011839)	5.06206184
8	Thyroiditis (HP:0100646)	4.76937628
9	Hypoplasia of the thymus (HP:0000778)	4.45532004
10	Combined immunodeficiency (HP:0005387)	4.17513003
11	Elevated erythrocyte sedimentation rate (HP:0003565)	4.10928508
12	Stomatitis (HP:0010280)	3.82811001
13	Eosinophilia (HP:0001880)	3.81362641
14	Abnormality of midbrain morphology (HP:0002418)	3.43858942
15	Molar tooth sign on MRI (HP:0002419)	3.43858942
16	Abnormality of eosinophils (HP:0001879)	3.39055560
17	IgG deficiency (HP:0004315)	3.37727509
18	Panhypogammaglobulinemia (HP:0003139)	3.35952300
19	Autoimmune hemolytic anemia (HP:0001890)	3.27794503
20	Microretrognathia (HP:0000308)	3.16833502
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.96594151
22	Granulocytopenia (HP:0001913)	2.94162678
23	Abnormality of the prostate (HP:0008775)	2.83469803
24	Abnormality of T cells (HP:0002843)	2.79317691
25	Gonadotropin excess (HP:0000837)	2.75734221
26	Anterior segment dysgenesis (HP:0007700)	2.67667107
27	Chronic sinusitis (HP:0011109)	2.66481326
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.62349559
29	Abnormality of alanine metabolism (HP:0010916)	2.62349559
30	Hyperalaninemia (HP:0003348)	2.62349559
31	Nephronophthisis (HP:0000090)	2.55075440
32	Erythroderma (HP:0001019)	2.54855789
33	Attenuation of retinal blood vessels (HP:0007843)	2.53800613
34	Congenital stationary night blindness (HP:0007642)	2.52280337
35	Decreased central vision (HP:0007663)	2.51802307
36	Exertional dyspnea (HP:0002875)	2.46224932
37	True hermaphroditism (HP:0010459)	2.44837892
38	Increased IgM level (HP:0003496)	2.42961610
39	Chronic diarrhea (HP:0002028)	2.42828482
40	Leukocytosis (HP:0001974)	2.41454598
41	Hyperinsulinemic hypoglycemia (HP:0000825)	2.37372610
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.35235957
43	Pancreatic cysts (HP:0001737)	2.34152780
44	Chest pain (HP:0100749)	2.33623615
45	Encephalitis (HP:0002383)	2.25731832
46	Cerebellar dysplasia (HP:0007033)	2.21061853
47	Lymphoma (HP:0002665)	2.18373918
48	3-Methylglutaconic aciduria (HP:0003535)	2.14331674
49	Neoplasm of the adrenal cortex (HP:0100641)	2.09472773
50	Methylmalonic acidemia (HP:0002912)	2.03658092
51	Recurrent viral infections (HP:0004429)	2.00546752
52	Chronic hepatic failure (HP:0100626)	2.00012322
53	Petechiae (HP:0000967)	1.99115185
54	Submucous cleft hard palate (HP:0000176)	1.98300421
55	Abolished electroretinogram (ERG) (HP:0000550)	1.96700473
56	Abnormality of the renal medulla (HP:0100957)	1.95357501
57	Mesangial abnormality (HP:0001966)	1.94436511
58	Meningitis (HP:0001287)	1.94423917
59	Colon cancer (HP:0003003)	1.93380468
60	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.92970988
61	Lissencephaly (HP:0001339)	1.87866136
62	Polycythemia (HP:0001901)	1.86786319
63	Recurrent bronchitis (HP:0002837)	1.85636715
64	Facial diplegia (HP:0001349)	1.85070684
65	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80350972
66	Focal motor seizures (HP:0011153)	1.80255369
67	Pancytopenia (HP:0001876)	1.80247575
68	Thyroid-stimulating hormone excess (HP:0002925)	1.78601746
69	Stomach cancer (HP:0012126)	1.77025182
70	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.75747383
71	Medial flaring of the eyebrow (HP:0010747)	1.74958770
72	Agammaglobulinemia (HP:0004432)	1.72231575
73	Macular degeneration (HP:0000608)	1.70575690
74	Nephrogenic diabetes insipidus (HP:0009806)	1.70072767
75	Severe visual impairment (HP:0001141)	1.69230414
76	Mitochondrial inheritance (HP:0001427)	1.69082890
77	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.67184595
78	Renal Fanconi syndrome (HP:0001994)	1.66649633
79	Abnormality of male internal genitalia (HP:0000022)	1.65296281
80	Increased intramyocellular lipid droplets (HP:0012240)	1.64636115
81	Methylmalonic aciduria (HP:0012120)	1.64241874
82	Partial agenesis of the corpus callosum (HP:0001338)	1.60159561
83	Pendular nystagmus (HP:0012043)	1.58042519
84	Recurrent fungal infections (HP:0002841)	1.56685812
85	Epidermoid cyst (HP:0200040)	1.56199586
86	Exocrine pancreatic insufficiency (HP:0001738)	1.55350167
87	Abnormal mitochondria in muscle tissue (HP:0008316)	1.53806993
88	Median cleft lip (HP:0000161)	1.53568050
89	Acute necrotizing encephalopathy (HP:0006965)	1.53508283
90	Amyotrophic lateral sclerosis (HP:0007354)	1.53415543
91	Lymphopenia (HP:0001888)	1.52187336
92	Sepsis (HP:0100806)	1.49683191
93	Autoimmune thrombocytopenia (HP:0001973)	1.49140307
94	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.49048828
95	Abnormal protein N-linked glycosylation (HP:0012347)	1.49048828
96	Abnormal protein glycosylation (HP:0012346)	1.49048828
97	Abnormal glycosylation (HP:0012345)	1.49048828
98	Recurrent corneal erosions (HP:0000495)	1.48581308
99	Optic nerve hypoplasia (HP:0000609)	1.48468545
100	Increased CSF protein (HP:0002922)	1.48461246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.65695359
2	AKT3	4.29842447
3	KDR	3.81384915
4	GRK1	3.34081166
5	BCKDK	3.25510657
6	TNIK	3.13429043
7	CDK9	2.46961966
8	NLK	2.46014338
9	PIK3CG	2.36293953
10	PNCK	2.13980174
11	TAOK3	2.05521867
12	PLK4	1.98742282
13	ITK	1.94644466
14	FRK	1.88464075
15	VRK1	1.78157750
16	TESK2	1.67471312
17	WEE1	1.65648032
18	MAP4K1	1.64397345
19	EPHA3	1.63202872
20	MAP4K2	1.42243457
21	ADRBK2	1.38144553
22	ERBB3	1.34055676
23	PLK2	1.32770573
24	WNK3	1.31321179
25	MUSK	1.28388529
26	MAPK13	1.20384043
27	STK38L	1.19004205
28	MAP3K6	1.16453333
29	VRK2	1.14211228
30	ZAP70	1.07924665
31	SCYL2	1.06025254
32	CSNK1G1	1.01698258
33	EIF2AK3	1.01126306
34	CDK19	1.00008987
35	PRKCE	0.99478899
36	MKNK1	0.99388418
37	MAP3K5	0.97202485
38	TTK	0.95879917
39	PIK3CA	0.95104991
40	TEC	0.94436208
41	CSNK1G3	0.94069467
42	PBK	0.93087251
43	MKNK2	0.92153162
44	CDC7	0.91127419
45	LCK	0.90369456
46	NUAK1	0.89212865
47	TYRO3	0.87521138
48	PIM1	0.87073276
49	CSNK1G2	0.86986488
50	EPHA4	0.86830950
51	SYK	0.85233394
52	DYRK3	0.81265537
53	SGK2	0.79726919
54	BMPR2	0.79275763
55	RPS6KA4	0.78025782
56	FES	0.77237799
57	PDK2	0.75519219
58	BRAF	0.72745359
59	RPS6KB1	0.72513965
60	PRKCQ	0.72135793
61	CSNK1A1L	0.67380355
62	ATR	0.66398944
63	MATK	0.63107030
64	CSK	0.62543009
65	BRSK2	0.61902792
66	BCR	0.59932003
67	ZAK	0.58944100
68	BTK	0.57660781
69	MAPK7	0.56789350
70	INSRR	0.54173438
71	LYN	0.52472403
72	BMPR1B	0.48725757
73	TAF1	0.47795162
74	DYRK2	0.46959007
75	IGF1R	0.46673351
76	PRKCG	0.46508424
77	CSNK2A1	0.45999046
78	OBSCN	0.44459100
79	PLK3	0.42838292
80	IKBKB	0.42333643
81	CSNK1D	0.41394858
82	KIT	0.39380640
83	PLK1	0.38745364
84	RPS6KA5	0.37184703
85	CSNK1A1	0.36098996
86	MAP3K4	0.35579219
87	ABL1	0.34349502
88	CSF1R	0.32743777
89	MELK	0.32134406
90	ATM	0.32085233
91	CDK3	0.31592566
92	MAPK3	0.30200957
93	CSNK1E	0.29977332
94	EPHB2	0.29305381
95	DYRK1A	0.29258318
96	PRKCB	0.29208048
97	MAP3K12	0.28773832
98	CSNK2A2	0.27426247
99	PRKCH	0.26819471
100	MAP2K6	0.26653664

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	6.31135497
2	Proteasome_Homo sapiens_hsa03050	3.21631080
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.93729291
4	Protein export_Homo sapiens_hsa03060	2.68077955
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.48937398
6	Allograft rejection_Homo sapiens_hsa05330	2.45630673
7	Antigen processing and presentation_Homo sapiens_hsa04612	2.45363868
8	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.26616409
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.21899073
10	RNA degradation_Homo sapiens_hsa03018	2.15248887
11	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.00018754
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.97653567
13	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.86883630
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68397062
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.65483582
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64834983
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64486906
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61149891
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61098516
20	RNA polymerase_Homo sapiens_hsa03020	1.61030102
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.59423977
22	Propanoate metabolism_Homo sapiens_hsa00640	1.56489422
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.50748755
24	Peroxisome_Homo sapiens_hsa04146	1.39396092
25	RNA transport_Homo sapiens_hsa03013	1.35710542
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34804670
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34062745
28	Parkinsons disease_Homo sapiens_hsa05012	1.31763238
29	Asthma_Homo sapiens_hsa05310	1.25390567
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23872835
31	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.23203056
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15894509
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12385534
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11590435
35	Retinol metabolism_Homo sapiens_hsa00830	1.10420222
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.08712231
37	DNA replication_Homo sapiens_hsa03030	1.07902491
38	Butanoate metabolism_Homo sapiens_hsa00650	1.06805903
39	Salmonella infection_Homo sapiens_hsa05132	1.02500660
40	Homologous recombination_Homo sapiens_hsa03440	1.01206525
41	Viral myocarditis_Homo sapiens_hsa05416	1.00798791
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.98201174
43	Phototransduction_Homo sapiens_hsa04744	0.97898614
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.96230411
45	Caffeine metabolism_Homo sapiens_hsa00232	0.95033237
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94057081
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93408651
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.91707799
49	Basal transcription factors_Homo sapiens_hsa03022	0.89755799
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86536620
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.86379363
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84415615
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.83848162
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80138947
55	Measles_Homo sapiens_hsa05162	0.77345159
56	Fatty acid elongation_Homo sapiens_hsa00062	0.77116256
57	Spliceosome_Homo sapiens_hsa03040	0.75865384
58	Taste transduction_Homo sapiens_hsa04742	0.73459333
59	Shigellosis_Homo sapiens_hsa05131	0.69724419
60	Alcoholism_Homo sapiens_hsa05034	0.69368957
61	Mismatch repair_Homo sapiens_hsa03430	0.68821898
62	Alzheimers disease_Homo sapiens_hsa05010	0.64107284
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64062399
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63146233
65	Olfactory transduction_Homo sapiens_hsa04740	0.62717760
66	ABC transporters_Homo sapiens_hsa02010	0.62335865
67	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60591015
68	Amphetamine addiction_Homo sapiens_hsa05031	0.59156893
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58646818
70	Huntingtons disease_Homo sapiens_hsa05016	0.57461834
71	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.56510125
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55123253
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.53738057
74	Mineral absorption_Homo sapiens_hsa04978	0.53379021
75	Malaria_Homo sapiens_hsa05144	0.52596895
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.52435328
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.48346443
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47479980
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46653948
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.45348501
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44324225
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43249983
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43187291
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43031341
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42510300
86	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41693555
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41523274
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40394338
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39361090
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35526818
91	Purine metabolism_Homo sapiens_hsa00230	0.33189935
92	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.28547302
93	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.27403031
94	Nicotine addiction_Homo sapiens_hsa05033	0.26635790
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.26049302
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.25196285
97	Metabolic pathways_Homo sapiens_hsa01100	0.24983575
98	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.23323014
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22787033
100	Thyroid cancer_Homo sapiens_hsa05216	0.22624406

RSL24D1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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