ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	7.99264034
2	positive regulation of interleukin-17 production (GO:0032740)	7.08210360
3	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	6.74400317
4	negative regulation of B cell apoptotic process (GO:0002903)	5.98193690
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.41418643
6	ATP synthesis coupled proton transport (GO:0015986)	5.41418643
7	purine deoxyribonucleotide catabolic process (GO:0009155)	5.41210488
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.35300576
9	regulation of regulatory T cell differentiation (GO:0045589)	4.88203404
10	regulation of isotype switching to IgG isotypes (GO:0048302)	4.86090773
11	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.61130316
12	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.59672105
13	regulation of interleukin-17 production (GO:0032660)	4.20244062
14	cytidine deamination (GO:0009972)	4.13279791
15	cytidine metabolic process (GO:0046087)	4.13279791
16	cytidine catabolic process (GO:0006216)	4.13279791
17	proteasome assembly (GO:0043248)	4.12326145
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07550587
19	respiratory electron transport chain (GO:0022904)	4.05429361
20	positive regulation of activated T cell proliferation (GO:0042104)	4.00241619
21	electron transport chain (GO:0022900)	3.95888226
22	deoxyribonucleotide catabolic process (GO:0009264)	3.91083518
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.86962266
24	deoxyribose phosphate catabolic process (GO:0046386)	3.86547882
25	DNA deamination (GO:0045006)	3.85292738
26	amino acid salvage (GO:0043102)	3.81891477
27	L-methionine salvage (GO:0071267)	3.81891477
28	L-methionine biosynthetic process (GO:0071265)	3.81891477
29	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.76470835
30	regulation of immunoglobulin secretion (GO:0051023)	3.70018885
31	sequestering of actin monomers (GO:0042989)	3.62569542
32	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	3.62152619
33	DNA double-strand break processing (GO:0000729)	3.61762300
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.61354452
35	nucleoside diphosphate catabolic process (GO:0009134)	3.58741644
36	negative regulation of heart contraction (GO:0045822)	3.55370676
37	regulation of B cell apoptotic process (GO:0002902)	3.54753601
38	cellular response to zinc ion (GO:0071294)	3.54308535
39	hydrogen ion transmembrane transport (GO:1902600)	3.48704008
40	oxidative phosphorylation (GO:0006119)	3.44969061
41	positive regulation of endothelial cell differentiation (GO:0045603)	3.44621711
42	negative regulation of telomere maintenance (GO:0032205)	3.35182248
43	regulation of cellular amino acid metabolic process (GO:0006521)	3.27013864
44	negative regulation of heart rate (GO:0010459)	3.25379851
45	positive regulation of isotype switching (GO:0045830)	3.21980049
46	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.19275185
47	positive regulation of B cell mediated immunity (GO:0002714)	3.19275185
48	spliceosomal complex assembly (GO:0000245)	3.18192510
49	proton transport (GO:0015992)	3.13460248
50	ATP biosynthetic process (GO:0006754)	3.13154142
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.12914563
52	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	3.09739259
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.05462426
54	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.05462426
55	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.05462426
56	hydrogen transport (GO:0006818)	3.04645304
57	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.03653856
58	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.03653856
59	positive regulation of JAK-STAT cascade (GO:0046427)	3.03223968
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.99435804
61	neutrophil mediated immunity (GO:0002446)	2.96838578
62	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.96519736
63	behavioral response to nicotine (GO:0035095)	2.91728621
64	positive regulation of T cell migration (GO:2000406)	2.89883462
65	histone mRNA metabolic process (GO:0008334)	2.89653530
66	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.87596953
67	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.87469651
68	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.86709573
69	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.86693986
70	protein neddylation (GO:0045116)	2.86391736
71	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.85939032
72	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.85939032
73	methionine metabolic process (GO:0006555)	2.85791784
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.84543652
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.84543652
76	hepatocyte apoptotic process (GO:0097284)	2.82448036
77	positive regulation of lymphocyte migration (GO:2000403)	2.81926247
78	one-carbon compound transport (GO:0019755)	2.81544137
79	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.81335008
80	positive regulation of DNA recombination (GO:0045911)	2.80247462
81	regulation of hypersensitivity (GO:0002883)	2.80246823
82	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77791883
83	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77498210
84	purine deoxyribonucleotide metabolic process (GO:0009151)	2.75770812
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.73306322
86	mismatch repair (GO:0006298)	2.72203697
87	regulation of endothelial cell differentiation (GO:0045601)	2.71531490
88	negative regulation of blood circulation (GO:1903523)	2.70876340
89	leukotriene biosynthetic process (GO:0019370)	2.70371735
90	methionine biosynthetic process (GO:0009086)	2.66929179
91	viral mRNA export from host cell nucleus (GO:0046784)	2.64268108
92	secretory granule organization (GO:0033363)	2.63563138
93	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.63221562
94	regulation of activated T cell proliferation (GO:0046006)	2.62307788
95	positive regulation of defense response to virus by host (GO:0002230)	2.60949467
96	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.60939596
97	somite rostral/caudal axis specification (GO:0032525)	2.59150233
98	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.57516061
99	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.54752530
100	negative regulation of ligase activity (GO:0051352)	2.53552091

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.30117440
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12037286
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.52011061
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43422549
5	TAF15_26573619_Chip-Seq_HEK293_Human	3.08946473
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.04405103
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.98227690
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91832433
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.72792496
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.72657605
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.52168575
12	FOXP3_21729870_ChIP-Seq_TREG_Human	2.33507301
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32371852
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23964949
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.17080710
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15598584
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12856296
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11695243
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.01371861
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.00040356
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94408916
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.85197539
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82993273
24	VDR_22108803_ChIP-Seq_LS180_Human	1.78016242
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74714989
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.73896623
27	EWS_26573619_Chip-Seq_HEK293_Human	1.72410330
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66702375
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59097830
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56138318
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54039349
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.51331419
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51307056
34	FUS_26573619_Chip-Seq_HEK293_Human	1.51276653
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48821928
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.47391993
37	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.46645494
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.43432618
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.43351019
40	GATA3_26560356_Chip-Seq_TH2_Human	1.40875836
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.39468589
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.34596398
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.34076768
44	P300_19829295_ChIP-Seq_ESCs_Human	1.31853065
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.29351116
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29042092
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29042092
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27270381
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.24291640
50	GBX2_23144817_ChIP-Seq_PC3_Human	1.22118839
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20941149
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.19698855
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19616361
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17793061
55	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.16310467
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.14585399
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13837094
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13837094
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13635016
60	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13427396
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.13256935
62	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.12971722
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.12726903
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12667104
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11000246
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09951352
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09473723
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09473382
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.08804220
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08785431
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07329870
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05655216
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04214091
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.03754037
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03598670
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02179153
77	P300_18555785_Chip-Seq_ESCs_Mouse	1.01960798
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00460696
79	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.99980817
80	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99656031
81	MYB_26560356_Chip-Seq_TH2_Human	0.98153632
82	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.97666137
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96987042
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96206351
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95953815
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95252325
87	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.95029768
88	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.95003163
89	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94891502
90	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94550404
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94132392
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.93542215
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93542215
94	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93504691
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92830421
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.91663329
97	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.90890566
98	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90339826
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.90180395
100	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89844216

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.65483310
2	MP0005671_abnormal_response_to	3.28904443
3	MP0003300_gastrointestinal_ulcer	3.15577486
4	MP0001853_heart_inflammation	3.09794037
5	MP0000465_gastrointestinal_hemorrhage	3.08948630
6	MP0002166_altered_tumor_susceptibility	2.86887992
7	MP0001188_hyperpigmentation	2.68760425
8	MP0009785_altered_susceptibility_to	2.43864000
9	MP0002006_tumorigenesis	2.43153575
10	MP0001529_abnormal_vocalization	2.39456685
11	MP0004142_abnormal_muscle_tone	2.33431492
12	MP0004145_abnormal_muscle_electrophysio	2.30909212
13	MP0002234_abnormal_pharynx_morphology	2.28924188
14	MP0002102_abnormal_ear_morphology	2.28239692
15	MP0008995_early_reproductive_senescence	2.27413811
16	MP0000604_amyloidosis	2.22494767
17	MP0002822_catalepsy	2.01706262
18	MP0009697_abnormal_copulation	1.97954951
19	MP0002837_dystrophic_cardiac_calcinosis	1.93829167
20	MP0003718_maternal_effect	1.90526950
21	MP0002148_abnormal_hypersensitivity_rea	1.89184299
22	MP0003186_abnormal_redox_activity	1.78912483
23	MP0009764_decreased_sensitivity_to	1.74155106
24	MP0003724_increased_susceptibility_to	1.70716226
25	MP0000569_abnormal_digit_pigmentation	1.63786228
26	MP0001800_abnormal_humoral_immune	1.63662334
27	MP0005646_abnormal_pituitary_gland	1.63101432
28	MP0001790_abnormal_immune_system	1.59618976
29	MP0005387_immune_system_phenotype	1.59618976
30	MP0005000_abnormal_immune_tolerance	1.57377607
31	MP0003786_premature_aging	1.56433955
32	MP0005645_abnormal_hypothalamus_physiol	1.51650246
33	MP0002736_abnormal_nociception_after	1.51255096
34	MP0003567_abnormal_fetal_cardiomyocyte	1.47374531
35	MP0004782_abnormal_surfactant_physiolog	1.46136500
36	MP0005025_abnormal_response_to	1.36886930
37	MP0001986_abnormal_taste_sensitivity	1.32648949
38	MP0001919_abnormal_reproductive_system	1.30404010
39	MP0006072_abnormal_retinal_apoptosis	1.29395769
40	MP0002405_respiratory_system_inflammati	1.27480883
41	MP0001501_abnormal_sleep_pattern	1.26796223
42	MP0008789_abnormal_olfactory_epithelium	1.25842619
43	MP0008875_abnormal_xenobiotic_pharmacok	1.25404338
44	MP0002009_preneoplasia	1.20504639
45	MP0006082_CNS_inflammation	1.19622845
46	MP0005499_abnormal_olfactory_system	1.18526609
47	MP0005394_taste/olfaction_phenotype	1.18526609
48	MP0009379_abnormal_foot_pigmentation	1.18492267
49	MP0005075_abnormal_melanosome_morpholog	1.18228496
50	MP0002272_abnormal_nervous_system	1.14381213
51	MP0002420_abnormal_adaptive_immunity	1.14343705
52	MP0001845_abnormal_inflammatory_respons	1.09977956
53	MP0000685_abnormal_immune_system	1.07819406
54	MP0001984_abnormal_olfaction	1.07677106
55	MP0001819_abnormal_immune_cell	1.07489650
56	MP0002452_abnormal_antigen_presenting	1.06523670
57	MP0002723_abnormal_immune_serum	1.06507959
58	MP0003195_calcinosis	1.06119179
59	MP0005084_abnormal_gallbladder_morpholo	1.06017192
60	MP0005423_abnormal_somatic_nervous	1.03078333
61	MP0003880_abnormal_central_pattern	0.99797902
62	MP0005551_abnormal_eye_electrophysiolog	0.99498266
63	MP0001440_abnormal_grooming_behavior	0.98066269
64	MP0001968_abnormal_touch/_nociception	0.97629976
65	MP0005253_abnormal_eye_physiology	0.96906864
66	MP0001970_abnormal_pain_threshold	0.95981018
67	MP0010386_abnormal_urinary_bladder	0.94052497
68	MP0002751_abnormal_autonomic_nervous	0.91280884
69	MP0002163_abnormal_gland_morphology	0.88217551
70	MP0005636_abnormal_mineral_homeostasis	0.88098744
71	MP0002933_joint_inflammation	0.85200548
72	MP0003252_abnormal_bile_duct	0.84912351
73	MP0001119_abnormal_female_reproductive	0.84623063
74	MP0000689_abnormal_spleen_morphology	0.83922491
75	MP0009333_abnormal_splenocyte_physiolog	0.82596234
76	MP0009745_abnormal_behavioral_response	0.79721006
77	MP0003221_abnormal_cardiomyocyte_apopto	0.77431870
78	MP0005410_abnormal_fertilization	0.76974472
79	MP0001764_abnormal_homeostasis	0.75996703
80	MP0008872_abnormal_physiological_respon	0.75763566
81	MP0003646_muscle_fatigue	0.74961768
82	MP0009763_increased_sensitivity_to	0.74047472
83	MP0000716_abnormal_immune_system	0.73708001
84	MP0006276_abnormal_autonomic_nervous	0.73065932
85	MP0002419_abnormal_innate_immunity	0.72937522
86	MP0000516_abnormal_urinary_system	0.72559465
87	MP0005367_renal/urinary_system_phenotyp	0.72559465
88	MP0002733_abnormal_thermal_nociception	0.70989439
89	MP0005389_reproductive_system_phenotype	0.70836088
90	MP0001765_abnormal_ion_homeostasis	0.69874392
91	MP0001502_abnormal_circadian_rhythm	0.69466755
92	MP0002638_abnormal_pupillary_reflex	0.69403636
93	MP0005332_abnormal_amino_acid	0.69345237
94	MP0002398_abnormal_bone_marrow	0.68327002
95	MP0006036_abnormal_mitochondrial_physio	0.68243433
96	MP0003866_abnormal_defecation	0.67131863
97	MP0001958_emphysema	0.66845722
98	MP0000249_abnormal_blood_vessel	0.65146527
99	MP0008469_abnormal_protein_level	0.63439171
100	MP0005647_abnormal_sex_gland	0.63269769

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.52421263
2	Acute necrotizing encephalopathy (HP:0006965)	4.42340421
3	3-Methylglutaconic aciduria (HP:0003535)	4.24605077
4	Increased hepatocellular lipid droplets (HP:0006565)	4.12619166
5	Mitochondrial inheritance (HP:0001427)	4.05333851
6	Retinal dysplasia (HP:0007973)	4.02094660
7	Severe combined immunodeficiency (HP:0004430)	4.00162909
8	Lipid accumulation in hepatocytes (HP:0006561)	3.81224434
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.79187393
10	Increased CSF lactate (HP:0002490)	3.67076295
11	Hepatocellular necrosis (HP:0001404)	3.62392980
12	Progressive macrocephaly (HP:0004481)	3.56571071
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.51451503
14	Thyroiditis (HP:0100646)	3.51154022
15	Abolished electroretinogram (ERG) (HP:0000550)	3.46685464
16	Aplastic anemia (HP:0001915)	3.42171763
17	Acute encephalopathy (HP:0006846)	3.33417481
18	Type 2 muscle fiber atrophy (HP:0003554)	3.29292128
19	Renal Fanconi syndrome (HP:0001994)	3.25489919
20	Exertional dyspnea (HP:0002875)	3.21583497
21	Spontaneous hematomas (HP:0007420)	3.10987032
22	Combined immunodeficiency (HP:0005387)	3.10360715
23	Hepatic necrosis (HP:0002605)	3.04965232
24	Molar tooth sign on MRI (HP:0002419)	3.02916728
25	Abnormality of midbrain morphology (HP:0002418)	3.02916728
26	Muscle fiber atrophy (HP:0100295)	3.01342477
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.96440908
28	B lymphocytopenia (HP:0010976)	2.94690348
29	IgG deficiency (HP:0004315)	2.90727598
30	Conjunctival telangiectasia (HP:0000524)	2.88813286
31	Autoimmune thrombocytopenia (HP:0001973)	2.82902634
32	Increased IgM level (HP:0003496)	2.82395110
33	Cerebral edema (HP:0002181)	2.72757257
34	Hypomagnesemia (HP:0002917)	2.72567057
35	Stomatitis (HP:0010280)	2.71784108
36	Respiratory failure (HP:0002878)	2.69027267
37	Chronic sinusitis (HP:0011109)	2.67397904
38	Medial flaring of the eyebrow (HP:0010747)	2.62584284
39	Abnormality of B cell number (HP:0010975)	2.58313194
40	Congenital primary aphakia (HP:0007707)	2.52794380
41	Gait imbalance (HP:0002141)	2.51342745
42	Nephrogenic diabetes insipidus (HP:0009806)	2.48738013
43	Microretrognathia (HP:0000308)	2.47177537
44	Type II lissencephaly (HP:0007260)	2.46556793
45	Pancreatic cysts (HP:0001737)	2.44714771
46	Increased serum lactate (HP:0002151)	2.44648580
47	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.44452308
48	Lip pit (HP:0100267)	2.40435406
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.39086257
50	Recurrent bronchitis (HP:0002837)	2.37050065
51	Increased intramyocellular lipid droplets (HP:0012240)	2.33311321
52	Abnormality of eosinophils (HP:0001879)	2.31486115
53	Hemoptysis (HP:0002105)	2.30198134
54	Hypoproteinemia (HP:0003075)	2.29152443
55	Abnormality of magnesium homeostasis (HP:0004921)	2.24764017
56	Leukodystrophy (HP:0002415)	2.22939397
57	Sensorimotor neuropathy (HP:0007141)	2.21869722
58	Optic disc pallor (HP:0000543)	2.15586189
59	Acute hepatic failure (HP:0006554)	2.11975804
60	Lactic acidosis (HP:0003128)	2.08134698
61	CNS demyelination (HP:0007305)	2.05939143
62	Increased muscle lipid content (HP:0009058)	2.04476888
63	Oral leukoplakia (HP:0002745)	2.03515815
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03278628
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03278628
66	Myokymia (HP:0002411)	2.00048072
67	Recurrent gram-negative bacterial infections (HP:0005420)	1.98109891
68	Dyskinesia (HP:0100660)	1.95702593
69	Abnormality of renal resorption (HP:0011038)	1.92522698
70	Decreased central vision (HP:0007663)	1.90474636
71	Microvesicular hepatic steatosis (HP:0001414)	1.90057077
72	Aqueductal stenosis (HP:0002410)	1.89420357
73	Eosinophilia (HP:0001880)	1.89135701
74	Cerebellar dysplasia (HP:0007033)	1.88372323
75	Myotonia (HP:0002486)	1.87721984
76	Bronchitis (HP:0012387)	1.87157597
77	Microcytic anemia (HP:0001935)	1.86984650
78	Exercise intolerance (HP:0003546)	1.86758561
79	Mesangial abnormality (HP:0001966)	1.86073735
80	Delayed CNS myelination (HP:0002188)	1.85576608
81	Panhypogammaglobulinemia (HP:0003139)	1.85121521
82	Chronic diarrhea (HP:0002028)	1.84049578
83	Nephronophthisis (HP:0000090)	1.81603348
84	Amyotrophic lateral sclerosis (HP:0007354)	1.79026959
85	Autoamputation (HP:0001218)	1.78439674
86	Retinitis pigmentosa (HP:0000510)	1.78400618
87	Pulmonary embolism (HP:0002204)	1.75958790
88	Pancreatic fibrosis (HP:0100732)	1.75533888
89	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.74794779
90	Renal cortical cysts (HP:0000803)	1.73423838
91	Tetany (HP:0001281)	1.72700386
92	Pancytopenia (HP:0001876)	1.71496358
93	Generalized aminoaciduria (HP:0002909)	1.69260767
94	Emotional lability (HP:0000712)	1.69223701
95	Obstructive lung disease (HP:0006536)	1.67956636
96	Chronic obstructive pulmonary disease (HP:0006510)	1.67956636
97	True hermaphroditism (HP:0010459)	1.66426165
98	Abnormality of urine glucose concentration (HP:0011016)	1.66422133
99	Glycosuria (HP:0003076)	1.66422133
100	Hypoplasia of the thymus (HP:0000778)	1.65719358

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK1	5.34308565
2	MAP3K12	3.42645610
3	BMPR2	3.38574453
4	CDK19	2.89057406
5	KDR	2.85383703
6	MAP4K2	2.82412623
7	TAOK3	2.52814376
8	TESK2	2.39929140
9	MST4	2.30994259
10	MYLK	2.08669212
11	PAK4	1.92937168
12	PIK3CG	1.92212044
13	OXSR1	1.92024377
14	WNK4	1.89799942
15	MAP2K7	1.83591160
16	GRK1	1.72839313
17	STK16	1.71984569
18	ZAK	1.59899819
19	DYRK3	1.58369687
20	RPS6KA4	1.57500976
21	BCR	1.50302855
22	ILK	1.44938762
23	DAPK1	1.42548263
24	CSNK1G3	1.42440938
25	WNK3	1.40596136
26	ERBB3	1.34670966
27	CSF1R	1.31330021
28	SCYL2	1.29077611
29	CLK1	1.26299539
30	MAP3K4	1.25575894
31	TRIM28	1.21839200
32	ADRBK2	1.21424480
33	DYRK2	1.16511667
34	LIMK1	1.15590330
35	STK39	1.10940324
36	STK38	1.10670247
37	CSNK1G2	1.09696908
38	ATR	1.08572105
39	RIPK4	1.05295399
40	MINK1	1.03146875
41	TEC	1.03004678
42	TXK	1.01440587
43	CSNK1G1	0.98018422
44	CDC7	0.93669258
45	MARK1	0.93603391
46	CSNK1A1L	0.92539700
47	INSRR	0.90308890
48	RPS6KA5	0.86987152
49	MAP3K6	0.82506743
50	MAPK13	0.79463030
51	PAK3	0.76063509
52	IKBKB	0.75727130
53	ITK	0.75516656
54	UHMK1	0.72814302
55	DAPK3	0.69133270
56	MAP3K5	0.65777167
57	FES	0.63269949
58	TNK2	0.62471752
59	NEK1	0.60775024
60	PIK3CA	0.59131690
61	CSK	0.57975190
62	VRK1	0.57864396
63	AURKB	0.57538876
64	SYK	0.56852886
65	OBSCN	0.51761771
66	PHKG2	0.49657294
67	PHKG1	0.49657294
68	FRK	0.49402387
69	NME2	0.48729724
70	LYN	0.47507085
71	PLK1	0.47238873
72	KIT	0.46232317
73	MAPK15	0.45208812
74	GRK7	0.45032616
75	BCKDK	0.45023318
76	NUAK1	0.44719675
77	CDK7	0.44695128
78	TLK1	0.44004354
79	CSNK2A1	0.43509808
80	PRKACA	0.41902203
81	PAK1	0.40984244
82	LCK	0.39471081
83	STK4	0.39153786
84	AURKA	0.38267858
85	TSSK6	0.38094791
86	CAMK2A	0.37846432
87	WNK1	0.37290397
88	PKN1	0.37149247
89	ROCK1	0.36359002
90	ZAP70	0.35732104
91	MAP2K6	0.34317198
92	BTK	0.31758409
93	PRKCA	0.31696420
94	CSNK2A2	0.31262694
95	PASK	0.30658440
96	IKBKE	0.30365848
97	CDK14	0.29416906
98	NME1	0.29385579
99	TIE1	0.28527799
100	PRKCE	0.28437307

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.48692061
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.29595227
3	Parkinsons disease_Homo sapiens_hsa05012	3.53430054
4	Asthma_Homo sapiens_hsa05310	3.44905868
5	Protein export_Homo sapiens_hsa03060	2.82537199
6	Allograft rejection_Homo sapiens_hsa05330	2.82102988
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.79873071
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.67920931
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.64528521
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.47853500
11	Alzheimers disease_Homo sapiens_hsa05010	2.42612726
12	Ribosome_Homo sapiens_hsa03010	2.40616632
13	Huntingtons disease_Homo sapiens_hsa05016	2.39052547
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31270718
15	Primary immunodeficiency_Homo sapiens_hsa05340	2.23788419
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.17232001
17	RNA polymerase_Homo sapiens_hsa03020	1.80961433
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61323281
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.41136301
20	RNA degradation_Homo sapiens_hsa03018	1.40685429
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.33482188
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33407878
23	Sulfur metabolism_Homo sapiens_hsa00920	1.30165885
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29234880
25	DNA replication_Homo sapiens_hsa03030	1.29208559
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.29194248
27	Homologous recombination_Homo sapiens_hsa03440	1.26291250
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20395101
29	Regulation of autophagy_Homo sapiens_hsa04140	1.18693655
30	One carbon pool by folate_Homo sapiens_hsa00670	1.17916064
31	Basal transcription factors_Homo sapiens_hsa03022	1.16020696
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.14333798
33	Spliceosome_Homo sapiens_hsa03040	1.06566658
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04773957
35	RNA transport_Homo sapiens_hsa03013	1.01977409
36	GABAergic synapse_Homo sapiens_hsa04727	1.01961516
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01730843
38	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97486945
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96745188
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.96092245
41	Antigen processing and presentation_Homo sapiens_hsa04612	0.95949814
42	Mismatch repair_Homo sapiens_hsa03430	0.95731019
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.95681935
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94736926
45	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.94650116
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.91066409
47	Salmonella infection_Homo sapiens_hsa05132	0.83531786
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81793858
49	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.77721664
50	Nicotine addiction_Homo sapiens_hsa05033	0.75256293
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73249515
52	Olfactory transduction_Homo sapiens_hsa04740	0.72915748
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71631756
54	Glutathione metabolism_Homo sapiens_hsa00480	0.71344045
55	Phototransduction_Homo sapiens_hsa04744	0.70528965
56	Purine metabolism_Homo sapiens_hsa00230	0.69340979
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.64800680
58	Salivary secretion_Homo sapiens_hsa04970	0.63994512
59	Morphine addiction_Homo sapiens_hsa05032	0.61740766
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57450964
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57283731
62	Peroxisome_Homo sapiens_hsa04146	0.56011580
63	Taste transduction_Homo sapiens_hsa04742	0.55996345
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53817081
65	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53469024
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53403708
67	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.53085972
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.49612926
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45102986
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44121092
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43928565
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43680351
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43259833
74	Pertussis_Homo sapiens_hsa05133	0.41479099
75	Metabolic pathways_Homo sapiens_hsa01100	0.40716064
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39079530
77	Propanoate metabolism_Homo sapiens_hsa00640	0.38999040
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37254066
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37218706
80	Circadian entrainment_Homo sapiens_hsa04713	0.36964710
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33498989
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32545632
83	Tyrosine metabolism_Homo sapiens_hsa00350	0.32377377
84	Serotonergic synapse_Homo sapiens_hsa04726	0.31715674
85	Viral myocarditis_Homo sapiens_hsa05416	0.30609985
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29010085
87	Mineral absorption_Homo sapiens_hsa04978	0.27416470
88	Retinol metabolism_Homo sapiens_hsa00830	0.26584286
89	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.26420727
90	p53 signaling pathway_Homo sapiens_hsa04115	0.25920227
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25815793
92	Shigellosis_Homo sapiens_hsa05131	0.25489502
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.24027741
94	Measles_Homo sapiens_hsa05162	0.23559970
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.22457607
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22393814
97	Phagosome_Homo sapiens_hsa04145	0.21816794
98	Fatty acid degradation_Homo sapiens_hsa00071	0.19715513
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.17039022
100	Base excision repair_Homo sapiens_hsa03410	0.15320125

RSL24D1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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