RSPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a male meiotic metaphase chromosome-associated acidic protein. This gene is expressed in tissues with motile cilia or flagella, including the trachea, lungs, airway brushings, and testes. Mutations in this gene result in primary ciliary dyskinesia-24. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.38944789
2acrosome assembly (GO:0001675)9.25731566
3multicellular organism reproduction (GO:0032504)9.17814599
4male meiosis (GO:0007140)9.08223328
5plasma membrane fusion (GO:0045026)8.78949100
6acrosome reaction (GO:0007340)8.70153044
7binding of sperm to zona pellucida (GO:0007339)8.66394288
8spermatid development (GO:0007286)8.46452947
9cell-cell recognition (GO:0009988)8.36553588
10synaptonemal complex organization (GO:0070193)8.28070130
11regulation of cilium movement (GO:0003352)7.90406873
12cell wall macromolecule metabolic process (GO:0044036)7.76847433
13cell wall macromolecule catabolic process (GO:0016998)7.76847433
14synaptonemal complex assembly (GO:0007130)7.53866200
15reproduction (GO:0000003)7.37007581
16primary alcohol catabolic process (GO:0034310)7.30409560
17male meiosis I (GO:0007141)7.12648709
18ventricular system development (GO:0021591)7.06964422
19DNA methylation involved in gamete generation (GO:0043046)6.84015969
20single fertilization (GO:0007338)6.62911943
21vitamin transmembrane transport (GO:0035461)6.39077852
22negative regulation of inclusion body assembly (GO:0090084)6.31296829
23ethanol metabolic process (GO:0006067)6.13131247
24diterpenoid biosynthetic process (GO:0016102)5.93614128
25fertilization (GO:0009566)5.90989325
26meiosis I (GO:0007127)5.80261886
27sperm capacitation (GO:0048240)5.76573462
28intraciliary transport (GO:0042073)5.61759248
29spermatogenesis (GO:0007283)5.45654892
30male gamete generation (GO:0048232)5.43676594
31meiotic nuclear division (GO:0007126)5.42215324
32* axoneme assembly (GO:0035082)5.39368203
33chromosome organization involved in meiosis (GO:0070192)5.27952739
34protein localization to cilium (GO:0061512)5.25199101
35regulation of inclusion body assembly (GO:0090083)5.05238036
36pyrimidine-containing compound transmembrane transport (GO:0072531)5.04642584
37nucleoside diphosphate phosphorylation (GO:0006165)5.04390707
38tolerance induction (GO:0002507)5.03799252
39one-carbon compound transport (GO:0019755)5.01958525
40gamete generation (GO:0007276)5.00624025
41germ cell development (GO:0007281)4.97266696
42GTP biosynthetic process (GO:0006183)4.93390314
43response to xenobiotic stimulus (GO:0009410)4.92481558
44lung epithelium development (GO:0060428)4.87926023
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.83121694
46regulation of microtubule-based movement (GO:0060632)4.82737531
47ethanol oxidation (GO:0006069)4.69668938
48left/right pattern formation (GO:0060972)4.67270337
49negative regulation of T cell differentiation in thymus (GO:0033085)4.65030495
50microtubule severing (GO:0051013)4.58873809
51seminiferous tubule development (GO:0072520)4.56268774
52establishment of apical/basal cell polarity (GO:0035089)4.54834457
53glomerular epithelial cell development (GO:0072310)4.48468729
54cilium organization (GO:0044782)4.46720589
55centriole assembly (GO:0098534)4.42784514
56UTP biosynthetic process (GO:0006228)4.40305562
57negative regulation of immunoglobulin mediated immune response (GO:0002890)4.37916790
58negative regulation of B cell mediated immunity (GO:0002713)4.37916790
59regulation of interleukin-5 production (GO:0032674)4.28158169
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.27413773
61negative regulation of humoral immune response (GO:0002921)4.26428002
62microtubule-based movement (GO:0007018)4.23653569
63cilium assembly (GO:0042384)4.21717534
64organic cation transport (GO:0015695)4.21674254
65centriole replication (GO:0007099)4.21292588
66left/right axis specification (GO:0070986)4.17443986
67* meiotic cell cycle (GO:0051321)4.16793163
68terpenoid biosynthetic process (GO:0016114)4.14908800
69regulation of germinal center formation (GO:0002634)4.10480606
70cell recognition (GO:0008037)4.08772030
71retinoic acid metabolic process (GO:0042573)4.07389555
72protein polyglutamylation (GO:0018095)4.04257387
73regulation of meiosis I (GO:0060631)4.02624740
74UTP metabolic process (GO:0046051)3.99559295
75establishment or maintenance of monopolar cell polarity (GO:0061339)3.98633249
76establishment of monopolar cell polarity (GO:0061162)3.98633249
77calcium ion-dependent exocytosis (GO:0017156)3.96976783
78multicellular organismal reproductive process (GO:0048609)3.93647468
79positive regulation of tolerance induction (GO:0002645)3.90246839
80regulation of interleukin-13 production (GO:0032656)3.90172724
81cilium morphogenesis (GO:0060271)3.89639578
82gene silencing by RNA (GO:0031047)3.87579080
83microtubule depolymerization (GO:0007019)3.78316074
84genitalia morphogenesis (GO:0035112)3.75028576
85cytoplasmic microtubule organization (GO:0031122)3.72122673
86* cellular component assembly involved in morphogenesis (GO:0010927)3.68994488
87protein refolding (GO:0042026)3.54848098
88lateral ventricle development (GO:0021670)3.53886235
89microtubule polymerization or depolymerization (GO:0031109)3.48646876
90chaperone-mediated protein complex assembly (GO:0051131)3.46485022
91guanosine-containing compound biosynthetic process (GO:1901070)3.41825118
92establishment of tissue polarity (GO:0007164)3.41027926
93establishment of planar polarity (GO:0001736)3.41027926
94meiotic cell cycle process (GO:1903046)3.40464885
95retinol metabolic process (GO:0042572)3.40206853
96exogenous drug catabolic process (GO:0042738)3.36478755
97primary alcohol metabolic process (GO:0034308)3.36318325
98negative regulation of organelle assembly (GO:1902116)3.33314252
99regulation of centriole replication (GO:0046599)3.31774966
100spermatid nucleus differentiation (GO:0007289)3.29656111
101CTP metabolic process (GO:0046036)3.28804421
102CTP biosynthetic process (GO:0006241)3.28804421
103glutathione derivative biosynthetic process (GO:1901687)3.24955917
104glutathione derivative metabolic process (GO:1901685)3.24955917
105O-glycan processing (GO:0016266)3.20644588
106synapsis (GO:0007129)3.10065353
107determination of left/right symmetry (GO:0007368)3.04894411
108positive regulation of smoothened signaling pathway (GO:0045880)3.04262465
109multicellular organismal development (GO:0007275)3.00848842
110pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00847996
111hydrogen peroxide biosynthetic process (GO:0050665)2.92819689
112determination of bilateral symmetry (GO:0009855)2.92610208
113phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.91446251
114aldehyde catabolic process (GO:0046185)2.90701093
115smoothened signaling pathway (GO:0007224)2.87113762
116monoubiquitinated protein deubiquitination (GO:0035520)2.86863037
117specification of symmetry (GO:0009799)2.85899574
118regulation of protein polyubiquitination (GO:1902914)2.84489149
119regulation of tolerance induction (GO:0002643)2.84021388
120* microtubule bundle formation (GO:0001578)2.83026933
121lactate metabolic process (GO:0006089)2.81834387
122lateral sprouting from an epithelium (GO:0060601)2.80812961
123multicellular organismal water homeostasis (GO:0050891)2.80481233
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79760159
125carnitine transmembrane transport (GO:1902603)2.79351435
126pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.79004393
127nucleotide phosphorylation (GO:0046939)2.77704523
128apical protein localization (GO:0045176)2.77182745
129amino-acid betaine transport (GO:0015838)2.76862745
130carnitine transport (GO:0015879)2.76862745
131carnitine metabolic process (GO:0009437)2.76235257
132nuclear pore complex assembly (GO:0051292)2.73384272
133regulation of microtubule depolymerization (GO:0031114)2.71756056
134retinal rod cell development (GO:0046548)2.70939829
135sex differentiation (GO:0007548)2.70175874
136* microtubule-based process (GO:0007017)2.69065846
137nucleoside diphosphate metabolic process (GO:0009132)2.65497304
138regulation of autophagic vacuole assembly (GO:2000785)2.64426543
139excretion (GO:0007588)2.63530721
140* cell projection assembly (GO:0030031)2.63281522
141reactive oxygen species biosynthetic process (GO:1903409)2.62925590
142hydrogen peroxide catabolic process (GO:0042744)2.62490630
143DNA alkylation (GO:0006305)2.60832739
144DNA methylation (GO:0006306)2.60832739
145drug catabolic process (GO:0042737)2.60238120
146phosphatidylcholine biosynthetic process (GO:0006656)2.59218579
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59109806
148peptidyl-glutamic acid modification (GO:0018200)2.58926323
149progesterone metabolic process (GO:0042448)2.57916802
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.53726276
151gene silencing (GO:0016458)2.50578652
152organelle assembly (GO:0070925)2.49683034
153oligosaccharide biosynthetic process (GO:0009312)2.43663420
154water homeostasis (GO:0030104)2.42836257
155protein O-linked glycosylation (GO:0006493)2.37993284
156sodium ion homeostasis (GO:0055078)2.37849213
157regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.36733557
158heart looping (GO:0001947)2.36356586
159embryonic camera-type eye development (GO:0031076)2.35193566
160nonmotile primary cilium assembly (GO:0035058)2.32465781
161CDP-diacylglycerol biosynthetic process (GO:0016024)2.31166181
162cilium or flagellum-dependent cell motility (GO:0001539)17.4120211
163axonemal dynein complex assembly (GO:0070286)13.7667315
164cilium movement (GO:0003341)11.8123784
165fusion of sperm to egg plasma membrane (GO:0007342)11.5707165
166epithelial cilium movement (GO:0003351)11.5537795
167piRNA metabolic process (GO:0034587)10.8587483
168motile cilium assembly (GO:0044458)10.7187969
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4120483
170sperm motility (GO:0030317)10.4049530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50471182
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.25418176
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.57383560
4DROSHA_22980978_ChIP-Seq_HELA_Human3.36299343
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.30170542
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05539366
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.98208860
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41788549
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.31698579
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.28126629
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.25925718
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.12635967
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03370657
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00572526
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8853971
16AHR_22903824_ChIP-Seq_MCF-7_Human1.95774727
17ZNF274_21170338_ChIP-Seq_K562_Hela1.94706590
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.91362016
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88982940
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88656138
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.87596434
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.85938582
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.83309110
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75130465
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.74253951
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.72842574
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.71820294
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71287826
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.68351658
30VDR_22108803_ChIP-Seq_LS180_Human1.67689252
31SMC4_20622854_ChIP-Seq_HELA_Human1.66531385
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66175311
33FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64718925
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61646358
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59820938
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.59164208
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55634482
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55158799
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54819266
40* TP63_23658742_ChIP-Seq_EP156T_Human1.54220592
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54173391
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53752149
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53421419
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52711399
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51133363
46* STAT1_20625510_ChIP-Seq_HELA_Human1.48954213
47KLF5_25053715_ChIP-Seq_YYC3_Human1.47480778
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45372554
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.44970358
50TP63_22573176_ChIP-Seq_HFKS_Human1.43912393
51* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43795183
52STAT1_17558387_ChIP-Seq_HELA_Human1.43539452
53CBP_20019798_ChIP-Seq_JUKART_Human1.43532969
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43532969
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43221590
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41727738
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41059212
58SOX2_20726797_ChIP-Seq_SW620_Human1.40224579
59KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39169076
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39155499
61ETV1_20927104_ChIP-Seq_GIST48_Human1.37959757
62TP53_18474530_ChIP-ChIP_U2OS_Human1.37521343
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35778831
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34901399
65REST_21632747_ChIP-Seq_MESCs_Mouse1.34722885
66SMRT_27268052_Chip-Seq_Bcells_Human1.34387859
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.33956873
68* FOXA1_25552417_ChIP-Seq_VCAP_Human1.33329085
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32638479
70RNF2_27304074_Chip-Seq_NSC_Mouse1.32637388
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32132178
72GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31800872
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31269279
74PHF8_20622853_ChIP-Seq_HELA_Human1.29355044
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29170611
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29170611
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.29059985
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.28631180
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28135276
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27755463
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27496442
82PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.27181088
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25802452
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.25632309
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.25465509
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23180230
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22361851
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.21101368
89GATA3_21867929_ChIP-Seq_CD8_Mouse1.18882240
90RBPJ_21746931_ChIP-Seq_IB4_Human1.17655645
91FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17604072
92BCAT_22108803_ChIP-Seq_LS180_Human1.17278431
93KDM2B_26808549_Chip-Seq_REH_Human1.16827930
94GATA1_19941826_ChIP-Seq_K562_Human1.15854387
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14050187
96CTCF_27219007_Chip-Seq_Bcells_Human1.13641951
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.12940583
98GATA4_25053715_ChIP-Seq_YYC3_Human1.12448145
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12231080
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.12217570
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12209254
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12124285
103CTCF_20526341_ChIP-Seq_ESCs_Human1.11930424
104SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11924940
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11156327
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.10442908
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08381680
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08246586
109ER_23166858_ChIP-Seq_MCF-7_Human1.07749070
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07210934
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.07141393
112GATA6_21074721_ChIP-Seq_CACO-2_Human1.06131930
113NFYA_21822215_ChIP-Seq_K562_Human1.05906365
114CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05890341
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.04614483
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.04183253
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.03761196
118P53_21459846_ChIP-Seq_SAOS-2_Human1.03436133
119P53_22387025_ChIP-Seq_ESCs_Mouse1.03190574
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03146659
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.02890965
122CEBPB_22108803_ChIP-Seq_LS180_Human1.02503940
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02033662
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02008352
125GF1_26923725_Chip-Seq_HPCs_Mouse1.01803693
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01769683
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01763607
128GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01623039
129TCF4_23295773_ChIP-Seq_U87_Human1.01577400
130SMAD4_21799915_ChIP-Seq_A2780_Human1.01400028
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00979925
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00816162
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.00723029
134GATA3_24758297_ChIP-Seq_MCF-7_Human1.00525386
135ERG_20517297_ChIP-Seq_VCAP_Human1.00222416
136ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00168016
137PHF8_20622854_ChIP-Seq_HELA_Human1.00064292
138P300_18555785_Chip-Seq_ESCs_Mouse1.00009526
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.99984440
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99979266
141P68_20966046_ChIP-Seq_HELA_Human0.98645203
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98632048
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.98458101
144GATA3_21867929_ChIP-Seq_TH1_Mouse0.97651839
145FOXA1_25329375_ChIP-Seq_VCAP_Human0.97388762
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97388762
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96864938
148TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96420948
149ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95619066
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95586543
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94349292
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94280743
153* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93832581
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.93178093
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92345799
156FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91657220
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91004797
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.90860873
159SOX2_21211035_ChIP-Seq_LN229_Human0.90184888
160CREB1_26743006_Chip-Seq_LNCaP_Human0.90042000
161NFYB_21822215_ChIP-Seq_K562_Human0.89409519
162TBL1_22424771_ChIP-Seq_293T_Human0.89206258
163PU1_27457419_Chip-Seq_LIVER_Mouse0.88937022
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88925436
165* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88519939
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88218570
167TCF4_22108803_ChIP-Seq_LS180_Human0.88080941
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87968672
169ZFX_18555785_Chip-Seq_ESCs_Mouse0.87686468
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87294202
171SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86885268
172GF1B_26923725_Chip-Seq_HPCs_Mouse0.86295784
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85573237
174RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85532067
175* P300_27268052_Chip-Seq_Bcells_Human0.85377360
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.85194269
177AR_21572438_ChIP-Seq_LNCaP_Human0.85129953
178AR_20517297_ChIP-Seq_VCAP_Human0.84517720
179CBP_21632823_ChIP-Seq_H3396_Human0.83341474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.89867060
2MP0008877_abnormal_DNA_methylation5.83850434
3* MP0003698_abnormal_male_reproductive5.72691805
4* MP0001929_abnormal_gametogenesis5.32995141
5MP0002653_abnormal_ependyma_morphology4.55613247
6MP0004043_abnormal_pH_regulation4.09327267
7MP0002210_abnormal_sex_determination3.99227828
8MP0009780_abnormal_chondrocyte_physiolo3.98763532
9MP0002277_abnormal_respiratory_mucosa3.50202211
10MP0008789_abnormal_olfactory_epithelium3.37499687
11MP0001145_abnormal_male_reproductive3.29480100
12* MP0002161_abnormal_fertility/fecundity3.06085357
13MP0000566_synostosis3.05626253
14MP0005623_abnormal_meninges_morphology3.03450129
15MP0000653_abnormal_sex_gland2.88173921
16MP0000383_abnormal_hair_follicle2.34475210
17MP0005394_taste/olfaction_phenotype2.23357601
18MP0005499_abnormal_olfactory_system2.23357601
19MP0010678_abnormal_skin_adnexa2.10840291
20MP0008057_abnormal_DNA_replication2.07691977
21MP0005410_abnormal_fertilization13.7359644
22MP0005083_abnormal_biliary_tract1.89988065
23MP0005670_abnormal_white_adipose1.83961393
24MP0002282_abnormal_trachea_morphology1.82346064
25MP0001984_abnormal_olfaction1.79108030
26MP0003656_abnormal_erythrocyte_physiolo1.66561288
27MP0000678_abnormal_parathyroid_gland1.65525687
28MP0010234_abnormal_vibrissa_follicle1.54157228
29MP0009046_muscle_twitch1.53798354
30MP0008995_early_reproductive_senescence1.50402523
31MP0003646_muscle_fatigue1.47502857
32MP0003136_yellow_coat_color1.42671167
33MP0001346_abnormal_lacrimal_gland1.40698072
34MP0005248_abnormal_Harderian_gland1.34137259
35MP0002249_abnormal_larynx_morphology1.28656503
36MP0005647_abnormal_sex_gland1.27434002
37MP0002734_abnormal_mechanical_nocicepti1.27342076
38MP0009379_abnormal_foot_pigmentation1.27184315
39* MP0002160_abnormal_reproductive_system1.27038511
40MP0005395_other_phenotype1.24154891
41MP0002876_abnormal_thyroid_physiology1.21301241
42MP0001485_abnormal_pinna_reflex1.16724885
43MP0000465_gastrointestinal_hemorrhage1.14428699
44MP0005165_increased_susceptibility_to1.13579695
45MP0002822_catalepsy1.13073104
46MP0010030_abnormal_orbit_morphology1.05852542
47MP0002735_abnormal_chemical_nociception1.05435288
48MP0005408_hypopigmentation1.04860270
49MP0008058_abnormal_DNA_repair1.02376506
50MP0001765_abnormal_ion_homeostasis0.99348302
51MP0004233_abnormal_muscle_weight0.98758228
52MP0010155_abnormal_intestine_physiology0.96758453
53MP0003786_premature_aging0.96421898
54MP0002928_abnormal_bile_duct0.95861918
55MP0002234_abnormal_pharynx_morphology0.94266331
56MP0000681_abnormal_thyroid_gland0.92712487
57MP0003011_delayed_dark_adaptation0.91694955
58MP0005164_abnormal_response_to0.91241538
59MP0004133_heterotaxia0.91070239
60MP0005377_hearing/vestibular/ear_phenot0.90153258
61MP0003878_abnormal_ear_physiology0.90153258
62MP0004883_abnormal_blood_vessel0.89545405
63MP0009643_abnormal_urine_homeostasis0.87493921
64MP0005365_abnormal_bile_salt0.84739607
65MP0001849_ear_inflammation0.84232536
66MP0010094_abnormal_chromosome_stability0.82968856
67MP0005220_abnormal_exocrine_pancreas0.82446599
68MP0003950_abnormal_plasma_membrane0.80431989
69MP0002136_abnormal_kidney_physiology0.78947076
70MP0008004_abnormal_stomach_pH0.77659721
71MP0000026_abnormal_inner_ear0.75252669
72MP0005085_abnormal_gallbladder_physiolo0.72818466
73MP0001545_abnormal_hematopoietic_system0.71281214
74MP0005397_hematopoietic_system_phenotyp0.71281214
75MP0001944_abnormal_pancreas_morphology0.70152872
76* MP0005389_reproductive_system_phenotype0.69281166
77MP0001270_distended_abdomen0.67562814
78MP0004264_abnormal_extraembryonic_tissu0.67010895
79MP0005646_abnormal_pituitary_gland0.66388551
80MP0001502_abnormal_circadian_rhythm0.66338722
81MP0003115_abnormal_respiratory_system0.66311757
82MP0004134_abnormal_chest_morphology0.65639988
83MP0005310_abnormal_salivary_gland0.65610227
84MP0008007_abnormal_cellular_replicative0.65101000
85MP0002098_abnormal_vibrissa_morphology0.64930212
86MP0005551_abnormal_eye_electrophysiolog0.63794017
87MP0001440_abnormal_grooming_behavior0.63465488
88MP0002139_abnormal_hepatobiliary_system0.62868472
89MP0009765_abnormal_xenobiotic_induced0.60463728
90MP0002102_abnormal_ear_morphology0.60041929
91MP0001727_abnormal_embryo_implantation0.59580143
92MP0005253_abnormal_eye_physiology0.59172886
93MP0001970_abnormal_pain_threshold0.59136077
94MP0001664_abnormal_digestion0.58625312
95MP0003329_amyloid_beta_deposits0.57792803
96MP0003303_peritoneal_inflammation0.56905347
97MP0000467_abnormal_esophagus_morphology0.56545736
98MP0001963_abnormal_hearing_physiology0.53719696
99MP0005391_vision/eye_phenotype0.53508688
100MP0005409_darkened_coat_color0.52526323
101MP0008872_abnormal_physiological_respon0.51854128
102MP0004808_abnormal_hematopoietic_stem0.50490756
103MP0000358_abnormal_cell_content/0.50355402
104MP0003861_abnormal_nervous_system0.50303438
105MP0002405_respiratory_system_inflammati0.49574585
106MP0001663_abnormal_digestive_system0.48776669
107MP0003634_abnormal_glial_cell0.48611302
108MP0003453_abnormal_keratinocyte_physiol0.48584995
109MP0001851_eye_inflammation0.48561779
110MP0001293_anophthalmia0.47820761
111MP0002152_abnormal_brain_morphology0.47337301
112MP0003938_abnormal_ear_development0.46980995
113MP0005503_abnormal_tendon_morphology0.46787387
114MP0003879_abnormal_hair_cell0.46647059
115MP0006072_abnormal_retinal_apoptosis0.46346809
116MP0003075_altered_response_to0.45796172
117MP0009763_increased_sensitivity_to0.44477114
118MP0001119_abnormal_female_reproductive0.44360697
119MP0009703_decreased_birth_body0.44258444
120MP0002896_abnormal_bone_mineralization0.44181366
121MP0005636_abnormal_mineral_homeostasis0.43295670
122MP0003699_abnormal_female_reproductive0.43119836
123MP0002132_abnormal_respiratory_system0.42922951
124MP0003942_abnormal_urinary_system0.42887484
125MP0000778_abnormal_nervous_system0.42058655
126MP0002135_abnormal_kidney_morphology0.41533322
127MP0003866_abnormal_defecation0.41366173
128MP0001666_abnormal_nutrient_absorption0.40283401
129MP0006036_abnormal_mitochondrial_physio0.39432582
130MP0004270_analgesia0.39185775
131MP0001879_abnormal_lymphatic_vessel0.39158191
132MP0001661_extended_life_span0.39083633
133MP0002092_abnormal_eye_morphology0.37678083
134MP0002572_abnormal_emotion/affect_behav0.34629567
135MP0002133_abnormal_respiratory_system0.33884459
136MP0005388_respiratory_system_phenotype0.33884459
137MP0003633_abnormal_nervous_system0.33178611
138MP0001324_abnormal_eye_pigmentation0.32574138
139MP0002557_abnormal_social/conspecific_i0.31793842
140MP0001919_abnormal_reproductive_system0.31755112
141MP0004811_abnormal_neuron_physiology0.31255672
142MP0003936_abnormal_reproductive_system0.31066561
143MP0005666_abnormal_adipose_tissue0.30625808
144MP0004742_abnormal_vestibular_system0.29421810
145MP0009278_abnormal_bone_marrow0.28935694
146MP0002909_abnormal_adrenal_gland0.27784668
147MP0002084_abnormal_developmental_patter0.27722966
148MP0002168_other_aberrant_phenotype0.27663178
149MP0005195_abnormal_posterior_eye0.27432708
150MP0000534_abnormal_ureter_morphology0.27153079
151MP0002971_abnormal_brown_adipose0.26997919
152MP0000955_abnormal_spinal_cord0.26932254
153MP0002295_abnormal_pulmonary_circulatio0.26751991
154MP0002272_abnormal_nervous_system0.26503318
155MP0000631_abnormal_neuroendocrine_gland0.25713364
156MP0003045_fibrosis0.25360751
157MP0000432_abnormal_head_morphology0.25026123
158MP0009250_abnormal_appendicular_skeleto0.25022087
159MP0003631_nervous_system_phenotype0.24873194
160MP0004019_abnormal_vitamin_homeostasis0.24676919
161MP0000751_myopathy0.23723858
162MP0002116_abnormal_craniofacial_bone0.23640437
163MP0002233_abnormal_nose_morphology0.23070385
164MP0002229_neurodegeneration0.22559148
165MP0002108_abnormal_muscle_morphology0.22354910
166MP0002638_abnormal_pupillary_reflex0.22147780
167MP0002736_abnormal_nociception_after0.22134073
168MP0009115_abnormal_fat_cell0.21283587

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.77395787
2Abnormal respiratory motile cilium morphology (HP:0005938)9.68374520
3Abnormal respiratory epithelium morphology (HP:0012253)9.68374520
4* Rhinitis (HP:0012384)8.30117653
5Chronic bronchitis (HP:0004469)7.29273460
6Nasal polyposis (HP:0100582)6.09550859
7* Bronchiectasis (HP:0002110)5.04934635
8* Infertility (HP:0000789)5.03760761
9Abnormality of the nasal mucosa (HP:0000433)5.00007635
10Nephronophthisis (HP:0000090)4.62467416
11Bronchitis (HP:0012387)4.34412503
12Abnormality of the renal medulla (HP:0100957)3.55028118
13Recurrent sinusitis (HP:0011108)3.51386360
14Recurrent otitis media (HP:0000403)3.22128539
15Tubulointerstitial nephritis (HP:0001970)3.20097385
16Atelectasis (HP:0100750)3.07468952
17Chronic otitis media (HP:0000389)3.04414153
18Medial flaring of the eyebrow (HP:0010747)3.03914662
19Molar tooth sign on MRI (HP:0002419)3.00738684
20Abnormality of midbrain morphology (HP:0002418)3.00738684
21Hyperactive renin-angiotensin system (HP:0000841)2.99837695
22Male infertility (HP:0003251)2.93638552
23Abnormality of the lower motor neuron (HP:0002366)2.89165587
24Chronic sinusitis (HP:0011109)2.88617737
25Fibular hypoplasia (HP:0003038)2.65593257
26Gonadotropin excess (HP:0000837)2.63961619
27Pancreatic fibrosis (HP:0100732)2.59855522
28Tubular atrophy (HP:0000092)2.58919961
29Postaxial foot polydactyly (HP:0001830)2.54006738
30Tubulointerstitial abnormality (HP:0001969)2.48480964
31Supernumerary spleens (HP:0009799)2.45470893
32Congenital hepatic fibrosis (HP:0002612)2.44300823
33True hermaphroditism (HP:0010459)2.38856431
34Recurrent bronchitis (HP:0002837)2.37838532
35Median cleft lip (HP:0000161)2.35731649
36Abnormality of dentin (HP:0010299)2.33422335
37Amyotrophic lateral sclerosis (HP:0007354)2.32082366
38Stage 5 chronic kidney disease (HP:0003774)2.20247896
39Abnormal spermatogenesis (HP:0008669)2.18078302
40Gait imbalance (HP:0002141)2.14466023
41Congenital primary aphakia (HP:0007707)2.13865254
42Facial cleft (HP:0002006)2.07479485
43Cystic liver disease (HP:0006706)2.03425465
44Abnormality of the dental root (HP:0006486)2.01688904
45Taurodontia (HP:0000679)2.01688904
46Abnormality of permanent molar morphology (HP:0011071)2.01688904
47Oculomotor apraxia (HP:0000657)2.00343222
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5204710
49Dynein arm defect of respiratory motile cilia (HP:0012255)11.4330902
50Absent/shortened dynein arms (HP:0200106)11.4330902
51Abnormal respiratory motile cilium physiology (HP:0012261)11.0341447
52Occipital encephalocele (HP:0002085)1.99260122
53Postaxial hand polydactyly (HP:0001162)1.92214267
54Decreased circulating renin level (HP:0003351)1.92046967
55Aplasia/Hypoplasia of the tongue (HP:0010295)1.89855131
56Abnormality of molar (HP:0011077)1.89454386
57Abnormality of molar morphology (HP:0011070)1.89454386
58Impaired proprioception (HP:0010831)1.88708976
59Tubulointerstitial fibrosis (HP:0005576)1.88040947
60Renal salt wasting (HP:0000127)1.87030780
61Nephrogenic diabetes insipidus (HP:0009806)1.85962201
62Azoospermia (HP:0000027)1.85370836
63Abnormality of the dental pulp (HP:0006479)1.81440547
6411 pairs of ribs (HP:0000878)1.80846438
65Short ribs (HP:0000773)1.76028239
66Bile duct proliferation (HP:0001408)1.75017386
67Abnormal biliary tract physiology (HP:0012439)1.75017386
68Pancreatic cysts (HP:0001737)1.73493986
69Impulsivity (HP:0100710)1.72810290
70Abnormality of the renal cortex (HP:0011035)1.72306029
71Asplenia (HP:0001746)1.72073753
72Renal dysplasia (HP:0000110)1.71355453
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.70564308
74Polydipsia (HP:0001959)1.69424111
75Abnormal drinking behavior (HP:0030082)1.69424111
76Hyperkalemia (HP:0002153)1.68742655
77Aplasia/Hypoplasia of the fibula (HP:0006492)1.66692617
78Furrowed tongue (HP:0000221)1.66660406
79Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62673251
80Absent frontal sinuses (HP:0002688)1.60287281
81Poor coordination (HP:0002370)1.58477730
82Genital tract atresia (HP:0001827)1.58018989
83Bell-shaped thorax (HP:0001591)1.56546398
84Vaginal atresia (HP:0000148)1.54659669
85Upper motor neuron abnormality (HP:0002127)1.53578484
86Hyperaldosteronism (HP:0000859)1.53314754
87Aplasia/Hypoplasia of the lens (HP:0008063)1.52039602
88Degeneration of anterior horn cells (HP:0002398)1.50481637
89Abnormality of the anterior horn cell (HP:0006802)1.50481637
90Short thorax (HP:0010306)1.48260629
91Abnormality of renin-angiotensin system (HP:0000847)1.47138796
92Microglossia (HP:0000171)1.46589126
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45795746
94Nephropathy (HP:0000112)1.44051506
95Short nail (HP:0001799)1.43428577
96J-shaped sella turcica (HP:0002680)1.41153688
97Abnormality of chloride homeostasis (HP:0011422)1.38565423
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34973458
99Chronic hepatic failure (HP:0100626)1.34762951
100Broad distal phalanx of finger (HP:0009836)1.33984814
101Preaxial hand polydactyly (HP:0001177)1.32738512
102Male pseudohermaphroditism (HP:0000037)1.32736199
103Abnormality of renal excretion (HP:0011036)1.31082502
104Absent epiphyses (HP:0010577)1.30241648
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30241648
106Hypokalemic alkalosis (HP:0001949)1.28274467
107Anencephaly (HP:0002323)1.25040068
108Decreased central vision (HP:0007663)1.22486056
109Sclerocornea (HP:0000647)1.21767593
110Hyponatremia (HP:0002902)1.18960037
111Abnormality of ocular smooth pursuit (HP:0000617)1.18250676
112Retinal dysplasia (HP:0007973)1.18061913
113Cone-rod dystrophy (HP:0000548)1.16708579
114Bifid scrotum (HP:0000048)1.16241331
115Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.15251500
116Fetal akinesia sequence (HP:0001989)1.14969076
117Short femoral neck (HP:0100864)1.14961836
118Glucose intolerance (HP:0000833)1.14160424
119Gaze-evoked nystagmus (HP:0000640)1.12954711
120Pachygyria (HP:0001302)1.12320020
121Hand muscle atrophy (HP:0009130)1.08551814
122Abnormality of the frontal sinuses (HP:0002687)1.08347214
123Abnormality of the distal phalanges of the toes (HP:0010182)1.07192774
124Popliteal pterygium (HP:0009756)1.05772691
125Abnormal rod and cone electroretinograms (HP:0008323)1.05009633
126Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.04799533
127Aplasia of the musculature (HP:0100854)0.98892555
128Abnormality of macular pigmentation (HP:0008002)0.98216100
129Retinitis pigmentosa (HP:0000510)0.95976559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.48991237
2PDK38.48991237
3PDK25.49209484
4EPHA24.72079697
5TESK14.48762118
6PNCK4.19408425
7PRKD33.58179477
8ICK3.08647769
9MAPK153.01578119
10PTK2B2.71599009
11WNK42.40095410
12MAPKAPK32.35271377
13STK392.32280232
14MAP3K22.20667097
15NME12.11228187
16STK242.05543423
17NEK21.78154092
18SMG11.66896598
19BCR1.41460496
20MAP3K31.40243034
21STK381.38864463
22WNK11.18956254
23WEE11.17241886
24LRRK21.13192191
25EPHB11.03075568
26TLK10.98028412
27TRPM70.96499251
28MST1R0.96219800
29TYRO30.96163171
30MAP3K70.95408124
31PRKCI0.91759034
32EPHA30.89023822
33CDC70.88331931
34STK30.86362633
35MARK20.85460985
36DYRK1B0.82247492
37MAP3K120.77615379
38IRAK10.77313111
39LMTK20.75788855
40TBK10.75377134
41PASK0.68711825
42PLK40.67924755
43NTRK20.67860202
44ERBB20.66803605
45PDK10.65877793
46DYRK30.63806529
47CAMK1G0.61088939
48CCNB10.60961439
49TTK0.59693713
50PINK10.59423535
51STK160.53122914
52PRKCG0.47302312
53CAMK2G0.47230990
54MAP4K20.46544744
55CHEK20.45406622
56CHEK10.44560847
57OXSR10.44043501
58PRKCD0.43920535
59NLK0.43868297
60FER0.43588441
61PAK20.43516578
62CDK120.43512616
63SGK10.41825410
64GRK60.40626451
65HIPK20.40191607
66INSRR0.39511175
67TSSK60.39111620
68PRKAA20.38397729
69TAOK10.37268919
70RPS6KB20.36778787
71ATR0.36270298
72ATM0.35395401
73GRK10.34200376
74WNK30.33391639
75EEF2K0.32110244
76MUSK0.31614131
77NEK60.31528438
78STK38L0.31450747
79IRAK20.29522390
80ROCK20.28829825
81FRK0.28679166
82CDK30.27908949
83ADRBK10.27294755
84PRKCA0.25722419
85PAK10.25594037
86FGFR30.25418560
87LATS10.25120051
88PLK10.24240755
89AKT20.24219587
90MAP2K20.24103465
91ABL10.24006361
92MYLK0.23711351
93TESK20.23613483
94MTOR0.23513516
95ROCK10.23384542
96MAP2K40.23150354
97AURKA0.21888916
98PRKAA10.21783812
99CAMKK10.20607759
100MAP3K40.20463410
101STK100.19782038
102BMPR1B0.19760625
103PLK20.19719088
104MAPKAPK50.17681277
105MINK10.16824445
106SRC0.16075652
107CAMKK20.15805020
108MET0.15782405
109BRSK20.15697354
110MAP2K10.15380189
111CDC42BPA0.14908815
112RPS6KA20.14852233
113FYN0.14827610
114RPS6KB10.14679442
115RIPK10.14601296
116GRK50.14362045
117MAP2K60.12702995
118ADRBK20.12598295
119ILK0.11919499
120PDPK10.11421293
121RIPK40.11280209
122PRKDC0.10544909
123MATK0.10339258
124PRKCE0.10303568
125PRKG10.09266311
126SGK2230.08764836
127MST40.07595839
128CSNK2A10.07203082
129CAMK2A0.07050952
130PRKACG0.06725047
131STK110.05800718
132MAP2K70.05770980
133BRAF0.05616895
134CSNK1D0.05398627
135PHKG20.05319332
136PHKG10.05319332
137VRK10.05214601
138MAPK100.04409303
139PAK60.03937210
140ERBB30.03813562
141CSNK2A20.03377865
142PRKCZ0.03188229
143PRKCQ0.03143297
144PRKACB0.03045125
145PRKCB0.02984609
146GSK3B0.02594104
147EGFR0.02574888
148PRKACA0.02469871
149MARK10.02393599
150SRPK10.02268915
151CDK10.02176526
152CSNK1E0.01740691
153PAK40.01482049
154PRKD20.01117871
155CSK0.01022305
156DYRK1A0.01016747
157RPS6KA30.01000538
158CDK20.00693311
159BRSK10.00327212
160YES10.00309698

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.78203608
2Phenylalanine metabolism_Homo sapiens_hsa003604.76874933
3Histidine metabolism_Homo sapiens_hsa003404.48472845
4Pyruvate metabolism_Homo sapiens_hsa006204.08841845
5Tyrosine metabolism_Homo sapiens_hsa003503.82565908
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.42558803
7Dorso-ventral axis formation_Homo sapiens_hsa043203.29871134
8Huntingtons disease_Homo sapiens_hsa050163.16184798
9beta-Alanine metabolism_Homo sapiens_hsa004103.03345760
10Propanoate metabolism_Homo sapiens_hsa006402.90458467
11Basal transcription factors_Homo sapiens_hsa030222.80833026
12Glucagon signaling pathway_Homo sapiens_hsa049222.77684675
13Fanconi anemia pathway_Homo sapiens_hsa034602.47255732
14Fatty acid biosynthesis_Homo sapiens_hsa000612.43976124
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41364083
16Caffeine metabolism_Homo sapiens_hsa002322.34118808
17Linoleic acid metabolism_Homo sapiens_hsa005912.33152248
18Selenocompound metabolism_Homo sapiens_hsa004502.18576004
19Amphetamine addiction_Homo sapiens_hsa050312.08471442
20Oocyte meiosis_Homo sapiens_hsa041142.03833820
21Pentose phosphate pathway_Homo sapiens_hsa000301.81432262
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76702817
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70421476
24Glycerolipid metabolism_Homo sapiens_hsa005611.69000489
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68570658
26Cardiac muscle contraction_Homo sapiens_hsa042601.67263380
27Renin secretion_Homo sapiens_hsa049241.57642177
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.49278573
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45620914
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.40110160
31Tight junction_Homo sapiens_hsa045301.39835495
32Ether lipid metabolism_Homo sapiens_hsa005651.39332509
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34213765
34PPAR signaling pathway_Homo sapiens_hsa033201.31925809
35mRNA surveillance pathway_Homo sapiens_hsa030151.31767993
36Fatty acid degradation_Homo sapiens_hsa000711.28342788
37Peroxisome_Homo sapiens_hsa041461.20973890
38Antigen processing and presentation_Homo sapiens_hsa046121.20138957
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19321620
40Purine metabolism_Homo sapiens_hsa002301.18343131
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.18078508
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13781827
43Long-term potentiation_Homo sapiens_hsa047201.11532437
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10458815
45RNA transport_Homo sapiens_hsa030131.06300238
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04329497
47Olfactory transduction_Homo sapiens_hsa047401.03053846
48Fructose and mannose metabolism_Homo sapiens_hsa000511.02765887
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01265083
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97083705
51Estrogen signaling pathway_Homo sapiens_hsa049150.97077794
52Circadian rhythm_Homo sapiens_hsa047100.96166388
53Arachidonic acid metabolism_Homo sapiens_hsa005900.94358858
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94319784
55Mineral absorption_Homo sapiens_hsa049780.94144859
56Calcium signaling pathway_Homo sapiens_hsa040200.92889504
57Carbon metabolism_Homo sapiens_hsa012000.92078980
58Glutathione metabolism_Homo sapiens_hsa004800.91618520
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90067774
60Starch and sucrose metabolism_Homo sapiens_hsa005000.87693432
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79349044
62Collecting duct acid secretion_Homo sapiens_hsa049660.79188027
63Insulin secretion_Homo sapiens_hsa049110.77413574
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76711855
65Taste transduction_Homo sapiens_hsa047420.75812774
66Hedgehog signaling pathway_Homo sapiens_hsa043400.74188044
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.73957128
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73348592
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72082743
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69832976
71Alzheimers disease_Homo sapiens_hsa050100.69378676
72Oxidative phosphorylation_Homo sapiens_hsa001900.68829276
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67034145
74ABC transporters_Homo sapiens_hsa020100.65454593
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.63565463
76Fat digestion and absorption_Homo sapiens_hsa049750.63342102
77Gastric acid secretion_Homo sapiens_hsa049710.61039049
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61017496
79Circadian entrainment_Homo sapiens_hsa047130.60918848
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.59363934
81Notch signaling pathway_Homo sapiens_hsa043300.59167732
82Choline metabolism in cancer_Homo sapiens_hsa052310.57532472
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57379584
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57366252
85Chemical carcinogenesis_Homo sapiens_hsa052040.56530465
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56443063
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.55625662
88N-Glycan biosynthesis_Homo sapiens_hsa005100.55191060
89Thyroid hormone synthesis_Homo sapiens_hsa049180.53704363
90Synaptic vesicle cycle_Homo sapiens_hsa047210.53309370
91Sphingolipid metabolism_Homo sapiens_hsa006000.52764264
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52035133
93Parkinsons disease_Homo sapiens_hsa050120.51081415
94Systemic lupus erythematosus_Homo sapiens_hsa053220.50671185
95Hepatitis C_Homo sapiens_hsa051600.48040457
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47706407
97Wnt signaling pathway_Homo sapiens_hsa043100.47334046
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.44829474
99Pyrimidine metabolism_Homo sapiens_hsa002400.44574086
100Salivary secretion_Homo sapiens_hsa049700.44500332
101cAMP signaling pathway_Homo sapiens_hsa040240.44485323
102Inositol phosphate metabolism_Homo sapiens_hsa005620.43149109
103Adherens junction_Homo sapiens_hsa045200.43108464
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43037633
105Cocaine addiction_Homo sapiens_hsa050300.42566029
106Alcoholism_Homo sapiens_hsa050340.42464635
107Nicotine addiction_Homo sapiens_hsa050330.41968640
108Homologous recombination_Homo sapiens_hsa034400.41891149
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.41667095
110AMPK signaling pathway_Homo sapiens_hsa041520.41456754
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.41059176
112Glutamatergic synapse_Homo sapiens_hsa047240.40788751
113Butanoate metabolism_Homo sapiens_hsa006500.39620991
114Fatty acid metabolism_Homo sapiens_hsa012120.39382817
115Metabolic pathways_Homo sapiens_hsa011000.38430378
116Phototransduction_Homo sapiens_hsa047440.38135060
117Dopaminergic synapse_Homo sapiens_hsa047280.36407738
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35882155
119Complement and coagulation cascades_Homo sapiens_hsa046100.35783518
120Type I diabetes mellitus_Homo sapiens_hsa049400.34800729
121Hematopoietic cell lineage_Homo sapiens_hsa046400.34504637
122Arginine and proline metabolism_Homo sapiens_hsa003300.33716957
123Serotonergic synapse_Homo sapiens_hsa047260.33124901
124Basal cell carcinoma_Homo sapiens_hsa052170.32227445
125RNA degradation_Homo sapiens_hsa030180.31038859
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31007723
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.30740720
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30158843
129Nitrogen metabolism_Homo sapiens_hsa009100.29949662
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29051362
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29010469
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28956631
133Biosynthesis of amino acids_Homo sapiens_hsa012300.28717112
134VEGF signaling pathway_Homo sapiens_hsa043700.26506197
135Lysosome_Homo sapiens_hsa041420.26320685
136Regulation of autophagy_Homo sapiens_hsa041400.26047894
137Retinol metabolism_Homo sapiens_hsa008300.25906910
138Tryptophan metabolism_Homo sapiens_hsa003800.25777814
139Oxytocin signaling pathway_Homo sapiens_hsa049210.25242722
140Bile secretion_Homo sapiens_hsa049760.23731359
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23695308
142Endocytosis_Homo sapiens_hsa041440.23520127
143Pancreatic secretion_Homo sapiens_hsa049720.23008181
144Hippo signaling pathway_Homo sapiens_hsa043900.22036161
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20929868
146Amoebiasis_Homo sapiens_hsa051460.20720773
147Vitamin digestion and absorption_Homo sapiens_hsa049770.18982132
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18688458
149Ovarian steroidogenesis_Homo sapiens_hsa049130.18685464
150Vibrio cholerae infection_Homo sapiens_hsa051100.18347868
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16350473
152Insulin resistance_Homo sapiens_hsa049310.16175563
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.11028273
154Melanogenesis_Homo sapiens_hsa049160.10143416
155Axon guidance_Homo sapiens_hsa043600.09694696
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08979405

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