RSPH4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)8.95174340
2GTP biosynthetic process (GO:0006183)8.33119584
3ventricular system development (GO:0021591)8.19518559
4left/right axis specification (GO:0070986)8.14245843
5nucleoside diphosphate phosphorylation (GO:0006165)7.97926845
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.73175605
7UTP biosynthetic process (GO:0006228)7.22527836
8primary alcohol catabolic process (GO:0034310)6.89568671
9UTP metabolic process (GO:0046051)6.61088458
10intraciliary transport (GO:0042073)6.20147688
11vitamin transmembrane transport (GO:0035461)5.93741514
12ethanol metabolic process (GO:0006067)5.64638971
13diterpenoid biosynthetic process (GO:0016102)5.53700262
14guanosine-containing compound biosynthetic process (GO:1901070)5.46185046
15CTP metabolic process (GO:0046036)5.40732340
16CTP biosynthetic process (GO:0006241)5.40732340
17cilium organization (GO:0044782)5.35437903
18motile cilium assembly (GO:0044458)5.21794160
19centriole assembly (GO:0098534)5.17486150
20cilium assembly (GO:0042384)5.03239523
21lung epithelium development (GO:0060428)4.86093528
22response to xenobiotic stimulus (GO:0009410)4.84881014
23pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.79124208
24cilium morphogenesis (GO:0060271)4.70864796
25tolerance induction (GO:0002507)4.62133669
26pyrimidine-containing compound transmembrane transport (GO:0072531)4.60329323
27nucleotide phosphorylation (GO:0046939)4.60276481
28regulation of cilium movement (GO:0003352)4.53523282
29pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.48257401
30* microtubule bundle formation (GO:0001578)4.43741939
31negative regulation of T cell differentiation in thymus (GO:0033085)4.37998709
32ethanol oxidation (GO:0006069)4.36133778
33negative regulation of immunoglobulin mediated immune response (GO:0002890)4.24028885
34negative regulation of B cell mediated immunity (GO:0002713)4.24028885
35sperm capacitation (GO:0048240)4.19667900
36sensory perception of smell (GO:0007608)4.18808009
37establishment of apical/basal cell polarity (GO:0035089)4.09478609
38regulation of interleukin-5 production (GO:0032674)4.03728470
39protein localization to cilium (GO:0061512)4.01963400
40microtubule depolymerization (GO:0007019)4.01322994
41* cellular component assembly involved in morphogenesis (GO:0010927)3.97574304
42terpenoid biosynthetic process (GO:0016114)3.97181844
43pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.96899585
44retinoic acid metabolic process (GO:0042573)3.95824081
45one-carbon compound transport (GO:0019755)3.94485732
46negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.89636388
47regulation of macrophage chemotaxis (GO:0010758)3.85548963
48nucleoside diphosphate metabolic process (GO:0009132)3.84154955
49regulation of mononuclear cell migration (GO:0071675)3.83119664
50* microtubule-based movement (GO:0007018)3.72049090
51oxygen transport (GO:0015671)3.71178031
52positive regulation of tolerance induction (GO:0002645)3.67904335
53establishment of tissue polarity (GO:0007164)3.66703171
54establishment of planar polarity (GO:0001736)3.66703171
55cytoplasmic microtubule organization (GO:0031122)3.62956665
56regulation of germinal center formation (GO:0002634)3.61201234
57regulation of interleukin-13 production (GO:0032656)3.58817562
58microtubule polymerization or depolymerization (GO:0031109)3.55159388
59regulation of glucose import in response to insulin stimulus (GO:2001273)3.52957257
60gas transport (GO:0015669)3.48843474
61brain morphogenesis (GO:0048854)3.47378445
62* cell projection assembly (GO:0030031)3.45053492
63lateral ventricle development (GO:0021670)3.43576322
64pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.38065570
65determination of left/right symmetry (GO:0007368)3.35611374
66centriole replication (GO:0007099)3.28993708
67exogenous drug catabolic process (GO:0042738)3.22667980
68determination of bilateral symmetry (GO:0009855)3.20235235
69positive regulation of smoothened signaling pathway (GO:0045880)3.19393199
70specification of symmetry (GO:0009799)3.15276149
71lateral sprouting from an epithelium (GO:0060601)3.13799941
72regulation of microtubule-based movement (GO:0060632)3.10576513
73detection of calcium ion (GO:0005513)3.09980289
74negative regulation of humoral immune response (GO:0002921)3.07720721
75nonmotile primary cilium assembly (GO:0035058)3.06245218
76retinol metabolic process (GO:0042572)3.05068078
77primary alcohol metabolic process (GO:0034308)3.04245337
78pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.03093841
79pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.02757573
80sperm motility (GO:0030317)3.02433470
81vocalization behavior (GO:0071625)2.98452940
82glutathione derivative biosynthetic process (GO:1901687)2.97031722
83glutathione derivative metabolic process (GO:1901685)2.97031722
84apical protein localization (GO:0045176)2.91862110
85hydrogen peroxide biosynthetic process (GO:0050665)2.86653886
86negative regulation of inclusion body assembly (GO:0090084)2.85804116
87* microtubule-based process (GO:0007017)2.85179043
88deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.83949998
89positive regulation of meiosis (GO:0045836)2.83555290
90organelle assembly (GO:0070925)2.82930247
91retinal rod cell development (GO:0046548)2.82899645
92aldehyde catabolic process (GO:0046185)2.82889113
93central nervous system myelination (GO:0022010)2.81108508
94axon ensheathment in central nervous system (GO:0032291)2.81108508
95ADP metabolic process (GO:0046031)2.80097944
96O-glycan processing (GO:0016266)2.79969995
97carnitine metabolic process (GO:0009437)2.79139134
98regulation of microtubule depolymerization (GO:0031114)2.77755549
99neuron cell-cell adhesion (GO:0007158)2.77578247
100female mating behavior (GO:0060180)2.76799615
101sensory perception of chemical stimulus (GO:0007606)2.76393124
102regulation of pigment cell differentiation (GO:0050932)2.72931428
103multicellular organismal aging (GO:0010259)2.68650638
104hair follicle development (GO:0001942)2.68193387
105heart looping (GO:0001947)2.66362720
106pyrimidine ribonucleotide metabolic process (GO:0009218)2.65826434
107negative regulation of astrocyte differentiation (GO:0048712)2.62372932
108regulation of tolerance induction (GO:0002643)2.62289009
109regulation of inclusion body assembly (GO:0090083)2.58234607
110positive regulation of meiotic cell cycle (GO:0051446)2.58140526
111smoothened signaling pathway (GO:0007224)2.56284961
112otic vesicle formation (GO:0030916)2.53531981
113reactive oxygen species biosynthetic process (GO:1903409)2.52457915
114drug catabolic process (GO:0042737)2.50459244
115regulation of autophagic vacuole assembly (GO:2000785)2.48667347
116positive regulation of cellular response to insulin stimulus (GO:1900078)2.48591009
117regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48514060
118phosphatidylcholine biosynthetic process (GO:0006656)2.48396687
119embryonic heart tube morphogenesis (GO:0003143)2.47679210
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.46504182
121photoreceptor cell maintenance (GO:0045494)2.46432743
122regulation of smoothened signaling pathway (GO:0008589)2.46384389
123glomerular epithelial cell development (GO:0072310)2.45419762
124embryonic camera-type eye development (GO:0031076)2.44235218
125excretion (GO:0007588)2.42836368
126protein refolding (GO:0042026)2.41922021
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41607255
128photoreceptor cell differentiation (GO:0046530)2.40424155
129eye photoreceptor cell differentiation (GO:0001754)2.40424155
130developmental induction (GO:0031128)2.39489268
131multicellular organismal water homeostasis (GO:0050891)2.39307686
132regulation of male gonad development (GO:2000018)2.38747601
133long-term synaptic potentiation (GO:0060291)2.36424340
134asymmetric protein localization (GO:0008105)2.36380038
135microtubule severing (GO:0051013)2.36027254
136regulation of collateral sprouting (GO:0048670)2.35368566
137purine nucleoside triphosphate biosynthetic process (GO:0009145)2.34607004
138pyrimidine nucleotide biosynthetic process (GO:0006221)2.33364451
139cornea development in camera-type eye (GO:0061303)2.33072806
140cell-cell signaling involved in cell fate commitment (GO:0045168)2.32824244
141adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.32273938
142left/right pattern formation (GO:0060972)2.30711198
143calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30523851
144retina layer formation (GO:0010842)2.28056628
145phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.27472818
146negative regulation of microtubule depolymerization (GO:0007026)2.26565017
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26387776
148polyketide metabolic process (GO:0030638)2.26209108
149doxorubicin metabolic process (GO:0044598)2.26209108
150daunorubicin metabolic process (GO:0044597)2.26209108
151pyrimidine ribonucleoside metabolic process (GO:0046131)2.26137546
152embryonic digestive tract development (GO:0048566)2.24836643
153establishment or maintenance of monopolar cell polarity (GO:0061339)2.19046950
154establishment of monopolar cell polarity (GO:0061162)2.19046950
155heart valve formation (GO:0003188)2.16835276
156negative regulation of cAMP-mediated signaling (GO:0043951)2.15352777
157cerebral cortex neuron differentiation (GO:0021895)2.14616816
158nucleoside triphosphate biosynthetic process (GO:0009142)2.13601873
159regulation of beta-amyloid formation (GO:1902003)2.10851192
160* cilium movement (GO:0003341)13.1571123
161axonemal dynein complex assembly (GO:0070286)12.6408782
162cilium or flagellum-dependent cell motility (GO:0001539)10.3307951
163* axoneme assembly (GO:0035082)10.1615442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.69003821
2EZH2_22144423_ChIP-Seq_EOC_Human3.63496411
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.15108817
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.06968229
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.72540522
6GBX2_23144817_ChIP-Seq_PC3_Human2.28115137
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07335021
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06426429
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99451188
10ESR1_20079471_ChIP-ChIP_T-47D_Human1.91416709
11SMAD4_21799915_ChIP-Seq_A2780_Human1.86718234
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85997303
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85453902
14P300_19829295_ChIP-Seq_ESCs_Human1.83712191
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83247077
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82296328
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81591252
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77846740
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.76871969
20FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76704132
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.76417265
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76409110
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76409110
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.76120988
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74551566
26RNF2_27304074_Chip-Seq_NSC_Mouse1.73131991
27AR_21572438_ChIP-Seq_LNCaP_Human1.73003660
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72506075
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.72214212
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.69308034
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69156679
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66962210
33VDR_22108803_ChIP-Seq_LS180_Human1.65102800
34DROSHA_22980978_ChIP-Seq_HELA_Human1.64771576
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.63975127
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63555501
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62802826
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60144676
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59205204
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58888482
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55500030
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.55412027
43REST_21632747_ChIP-Seq_MESCs_Mouse1.53172163
44BCAT_22108803_ChIP-Seq_LS180_Human1.52628075
45TP63_23658742_ChIP-Seq_EP156T_Human1.49699808
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49133825
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.48872639
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47299882
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46382572
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45533355
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45397877
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44866479
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.44686342
54TAF15_26573619_Chip-Seq_HEK293_Human1.44389066
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.42503831
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42009304
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.41623266
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40033388
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39564642
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38965031
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38812734
62ETV1_20927104_ChIP-Seq_GIST48_Human1.38326933
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.38139842
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.36360828
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35504835
66STAT1_20625510_ChIP-Seq_HELA_Human1.34858507
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34849137
68SMC4_20622854_ChIP-Seq_HELA_Human1.34826184
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34421655
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.33137169
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32238031
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31689376
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31681272
74TP53_18474530_ChIP-ChIP_U2OS_Human1.31659933
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31303507
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30420544
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30420544
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30272130
79STAT3_23295773_ChIP-Seq_U87_Human1.30194129
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30088638
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.29842083
82KLF5_25053715_ChIP-Seq_YYC3_Human1.29477491
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.29143859
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28803839
85PHF8_20622853_ChIP-Seq_HELA_Human1.27255353
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.26050528
87ER_23166858_ChIP-Seq_MCF-7_Human1.25962450
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25443415
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.23079541
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22926450
91AHR_22903824_ChIP-Seq_MCF-7_Human1.22496380
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.22064913
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21065938
94TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20607571
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19870948
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19865028
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18449424
98SMRT_27268052_Chip-Seq_Bcells_Human1.17884615
99AR_25329375_ChIP-Seq_VCAP_Human1.17792735
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.17549318
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.17538019
102SOX2_20726797_ChIP-Seq_SW620_Human1.17284052
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17034396
104RUNX2_22187159_ChIP-Seq_PCA_Human1.16782162
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16057037
106TCF4_22108803_ChIP-Seq_LS180_Human1.15671417
107P53_22387025_ChIP-Seq_ESCs_Mouse1.15436649
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15141770
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13370226
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12522935
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.12172157
112FUS_26573619_Chip-Seq_HEK293_Human1.11686372
113RBPJ_21746931_ChIP-Seq_IB4_Human1.10695482
114TP63_22573176_ChIP-Seq_HFKS_Human1.10389106
115NFYA_21822215_ChIP-Seq_K562_Human1.10234850
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09999748
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09442098
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.09213509
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.08924750
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.08806461
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08472121
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07734542
123CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07713994
124TBL1_22424771_ChIP-Seq_293T_Human1.07379723
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07294030
126TCF4_23295773_ChIP-Seq_U87_Human1.07258771
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06131047
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06110214
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.05660803
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05466544
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05198888
132CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04320696
133NFYB_21822215_ChIP-Seq_K562_Human1.04084736
134P300_18555785_Chip-Seq_ESCs_Mouse1.03576317
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03521691
136SMAD4_21741376_ChIP-Seq_HESCs_Human1.02954170
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02579875
138ZFX_18555785_Chip-Seq_ESCs_Mouse1.01701733
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00576297
140SMAD3_21741376_ChIP-Seq_HESCs_Human1.00537368
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00204531
142EZH2_27294783_Chip-Seq_NPCs_Mouse1.00164761
143GATA6_21074721_ChIP-Seq_CACO-2_Human0.99562635
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99555366
145* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99124904
146GATA4_25053715_ChIP-Seq_YYC3_Human0.98784921
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96979219
148WDR5_24793694_ChIP-Seq_LNCAP_Human0.96972030
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95663029
150FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95300656
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94290878
152CTCF_27219007_Chip-Seq_Bcells_Human0.93982402
153TP53_16413492_ChIP-PET_HCT116_Human0.91835879
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91041014
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.90731935
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90731935
157AR_20517297_ChIP-Seq_VCAP_Human0.89886085
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.87729496
159SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85508013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.71630350
2MP0001984_abnormal_olfaction4.81934811
3MP0002653_abnormal_ependyma_morphology3.71323824
4MP0004043_abnormal_pH_regulation3.43260847
5MP0005646_abnormal_pituitary_gland3.23151597
6MP0000566_synostosis3.19656010
7MP0008004_abnormal_stomach_pH3.16734683
8MP0004133_heterotaxia3.05938422
9MP0005623_abnormal_meninges_morphology3.01824224
10MP0000383_abnormal_hair_follicle2.53927333
11MP0001440_abnormal_grooming_behavior2.33836510
12MP0004859_abnormal_synaptic_plasticity2.28422279
13MP0009046_muscle_twitch2.15080942
14MP0004019_abnormal_vitamin_homeostasis2.06758249
15MP0004858_abnormal_nervous_system2.06332625
16MP0005499_abnormal_olfactory_system2.06190602
17MP0005394_taste/olfaction_phenotype2.06190602
18MP0005645_abnormal_hypothalamus_physiol2.05688524
19MP0010678_abnormal_skin_adnexa2.05186161
20MP0008789_abnormal_olfactory_epithelium1.98902610
21MP0001501_abnormal_sleep_pattern1.96742657
22MP0002734_abnormal_mechanical_nocicepti1.94225851
23MP0000778_abnormal_nervous_system1.85531684
24MP0009745_abnormal_behavioral_response1.84333006
25MP0006292_abnormal_olfactory_placode1.82718633
26MP0003880_abnormal_central_pattern1.80822438
27MP0002928_abnormal_bile_duct1.77340698
28MP0003656_abnormal_erythrocyte_physiolo1.74268431
29MP0002064_seizures1.72366174
30MP0003635_abnormal_synaptic_transmissio1.72181885
31MP0002249_abnormal_larynx_morphology1.70971286
32MP0006276_abnormal_autonomic_nervous1.68938614
33MP0010030_abnormal_orbit_morphology1.68881967
34MP0002638_abnormal_pupillary_reflex1.67970198
35MP0002572_abnormal_emotion/affect_behav1.66684460
36MP0004782_abnormal_surfactant_physiolog1.64006224
37MP0002557_abnormal_social/conspecific_i1.63285876
38MP0001485_abnormal_pinna_reflex1.63253641
39MP0003122_maternal_imprinting1.60516602
40MP0002160_abnormal_reproductive_system1.58989402
41MP0005248_abnormal_Harderian_gland1.57890451
42MP0001968_abnormal_touch/_nociception1.56348547
43MP0002063_abnormal_learning/memory/cond1.55889573
44MP0002272_abnormal_nervous_system1.55807765
45MP0005379_endocrine/exocrine_gland_phen1.54505459
46MP0005083_abnormal_biliary_tract1.50463006
47MP0009379_abnormal_foot_pigmentation1.49640146
48MP0002277_abnormal_respiratory_mucosa1.46773067
49MP0001486_abnormal_startle_reflex1.45732812
50MP0003690_abnormal_glial_cell1.45684932
51MP0001346_abnormal_lacrimal_gland1.45552672
52MP0001765_abnormal_ion_homeostasis1.45057661
53MP0003634_abnormal_glial_cell1.41436490
54MP0002735_abnormal_chemical_nociception1.40427704
55MP0005551_abnormal_eye_electrophysiolog1.39408552
56MP0002876_abnormal_thyroid_physiology1.36066077
57MP0004742_abnormal_vestibular_system1.33245714
58MP0002736_abnormal_nociception_after1.32624845
59MP0002938_white_spotting1.30968359
60MP0001177_atelectasis1.29960845
61MP0003890_abnormal_embryonic-extraembry1.24194687
62MP0000631_abnormal_neuroendocrine_gland1.24178743
63MP0002909_abnormal_adrenal_gland1.21972528
64MP0000026_abnormal_inner_ear1.20363296
65MP0009780_abnormal_chondrocyte_physiolo1.19216046
66MP0004142_abnormal_muscle_tone1.19030342
67MP0001502_abnormal_circadian_rhythm1.16516647
68MP0001970_abnormal_pain_threshold1.14362069
69MP0002067_abnormal_sensory_capabilities1.11833274
70MP0008875_abnormal_xenobiotic_pharmacok1.11683792
71MP0004381_abnormal_hair_follicle1.11098992
72MP0000678_abnormal_parathyroid_gland1.10390587
73MP0002184_abnormal_innervation1.08980876
74MP0002282_abnormal_trachea_morphology1.07881067
75MP0005388_respiratory_system_phenotype1.07858695
76MP0002133_abnormal_respiratory_system1.07858695
77MP0005395_other_phenotype1.04938158
78MP0002233_abnormal_nose_morphology1.03773967
79MP0001963_abnormal_hearing_physiology1.02857770
80MP0000049_abnormal_middle_ear1.01264024
81MP0002882_abnormal_neuron_morphology1.00539246
82MP0001293_anophthalmia0.98261809
83MP0002168_other_aberrant_phenotype0.96316185
84MP0005636_abnormal_mineral_homeostasis0.95114625
85MP0005423_abnormal_somatic_nervous0.94131887
86MP0003937_abnormal_limbs/digits/tail_de0.92964573
87MP0003633_abnormal_nervous_system0.92782053
88MP0005167_abnormal_blood-brain_barrier0.92045409
89MP0002752_abnormal_somatic_nervous0.90847287
90MP0005389_reproductive_system_phenotype0.89268329
91MP0003878_abnormal_ear_physiology0.88833362
92MP0005377_hearing/vestibular/ear_phenot0.88833362
93MP0004270_analgesia0.88362319
94MP0002152_abnormal_brain_morphology0.87957055
95MP0003879_abnormal_hair_cell0.87181916
96MP0001905_abnormal_dopamine_level0.85376866
97MP0003938_abnormal_ear_development0.84753568
98MP0004885_abnormal_endolymph0.83104802
99MP0001188_hyperpigmentation0.82428915
100MP0005171_absent_coat_pigmentation0.81033582
101MP0005220_abnormal_exocrine_pancreas0.80462687
102MP0002733_abnormal_thermal_nociception0.79665132
103MP0005391_vision/eye_phenotype0.78034363
104MP0003698_abnormal_male_reproductive0.77903473
105MP0001324_abnormal_eye_pigmentation0.77449747
106MP0001929_abnormal_gametogenesis0.75524640
107MP0005253_abnormal_eye_physiology0.74477132
108MP0001270_distended_abdomen0.74118882
109MP0000465_gastrointestinal_hemorrhage0.73589631
110MP0002229_neurodegeneration0.73147091
111MP0003941_abnormal_skin_development0.73072655
112MP0000428_abnormal_craniofacial_morphol0.72662170
113MP0005647_abnormal_sex_gland0.71844153
114MP0002295_abnormal_pulmonary_circulatio0.71806824
115MP0001299_abnormal_eye_distance/0.71589010
116MP0005503_abnormal_tendon_morphology0.71100604
117MP0003283_abnormal_digestive_organ0.70497992
118MP0002132_abnormal_respiratory_system0.69684657
119MP0005165_increased_susceptibility_to0.69071448
120MP0003861_abnormal_nervous_system0.68994654
121MP0003075_altered_response_to0.68303482
122MP0005386_behavior/neurological_phenoty0.67052376
123MP0004924_abnormal_behavior0.67052376
124MP0009703_decreased_birth_body0.66631903
125MP0000955_abnormal_spinal_cord0.66627806
126MP0005365_abnormal_bile_salt0.65981637
127MP0002116_abnormal_craniofacial_bone0.65935067
128MP0001286_abnormal_eye_development0.65009243
129MP0002066_abnormal_motor_capabilities/c0.64924913
130MP0006072_abnormal_retinal_apoptosis0.64510198
131MP0005408_hypopigmentation0.63893674
132MP0002098_abnormal_vibrissa_morphology0.63775164
133MP0003724_increased_susceptibility_to0.63410406
134MP0005195_abnormal_posterior_eye0.62971984
135MP0001944_abnormal_pancreas_morphology0.60871999
136MP0000681_abnormal_thyroid_gland0.60443222
137MP0002092_abnormal_eye_morphology0.59890169
138MP0001849_ear_inflammation0.59763916
139MP0009643_abnormal_urine_homeostasis0.59439091
140MP0003942_abnormal_urinary_system0.58276608
141MP0004883_abnormal_blood_vessel0.57485131
142MP0002136_abnormal_kidney_physiology0.56000293
143MP0001664_abnormal_digestion0.53615627
144MP0010155_abnormal_intestine_physiology0.52323581
145MP0002084_abnormal_developmental_patter0.50556728
146MP0005085_abnormal_gallbladder_physiolo0.50055053
147MP0010234_abnormal_vibrissa_follicle0.48423050
148MP0008872_abnormal_physiological_respon0.47817911
149MP0003943_abnormal_hepatobiliary_system0.47462179
150MP0005084_abnormal_gallbladder_morpholo0.47409289
151MP0005164_abnormal_response_to0.47238381
152MP0003806_abnormal_nucleotide_metabolis0.47179891

Predicted human phenotypes

RankGene SetZ-score
1* Rhinitis (HP:0012384)9.22245852
2* Abnormal respiratory epithelium morphology (HP:0012253)7.47808459
3* Abnormal respiratory motile cilium morphology (HP:0005938)7.47808459
4Chronic bronchitis (HP:0004469)6.93962517
5Absent/shortened dynein arms (HP:0200106)6.59160007
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.59160007
7* Bronchiectasis (HP:0002110)5.47627088
8Pancreatic fibrosis (HP:0100732)4.93675852
9True hermaphroditism (HP:0010459)4.70096179
10Chronic sinusitis (HP:0011109)4.05009265
11Median cleft lip (HP:0000161)3.78762924
12Nasal polyposis (HP:0100582)3.68469675
13Occipital encephalocele (HP:0002085)3.49463823
14Abnormality of midbrain morphology (HP:0002418)3.48918455
15Molar tooth sign on MRI (HP:0002419)3.48918455
16Gait imbalance (HP:0002141)3.36488966
17Abnormal biliary tract physiology (HP:0012439)3.34053539
18Bile duct proliferation (HP:0001408)3.34053539
19Congenital primary aphakia (HP:0007707)3.23836263
20Pancreatic cysts (HP:0001737)3.20543953
21Nephronophthisis (HP:0000090)3.19396257
22Bronchitis (HP:0012387)3.11993117
23Medial flaring of the eyebrow (HP:0010747)3.09763268
24Abnormality of the nasal mucosa (HP:0000433)3.06928192
25Abnormality of dentin (HP:0010299)3.06152107
26Chronic otitis media (HP:0000389)3.05658632
27Chronic hepatic failure (HP:0100626)3.00184696
28Congenital hepatic fibrosis (HP:0002612)2.96417552
29Supernumerary spleens (HP:0009799)2.89464800
30Nephrogenic diabetes insipidus (HP:0009806)2.84032509
31Cystic liver disease (HP:0006706)2.80275038
32Tubulointerstitial nephritis (HP:0001970)2.75079879
33Infertility (HP:0000789)2.72146125
34Genital tract atresia (HP:0001827)2.67402236
35Postaxial foot polydactyly (HP:0001830)2.62110751
36Abnormality of the renal medulla (HP:0100957)2.46849230
37Vaginal atresia (HP:0000148)2.46289729
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.44959369
39Facial cleft (HP:0002006)2.38654600
40Preaxial hand polydactyly (HP:0001177)2.37290003
41Male pseudohermaphroditism (HP:0000037)2.36997771
42Poor coordination (HP:0002370)2.36352567
43Recurrent otitis media (HP:0000403)2.31249806
44Abnormality of permanent molar morphology (HP:0011071)2.22945421
45Abnormality of the dental root (HP:0006486)2.22945421
46Taurodontia (HP:0000679)2.22945421
47Abnormal sex determination (HP:0012244)2.20157230
48Sex reversal (HP:0012245)2.20157230
49Neoplasm of head and neck (HP:0012288)2.17810667
50Esophageal neoplasm (HP:0100751)2.17810667
51Abdominal situs inversus (HP:0003363)2.16227973
52Abnormality of abdominal situs (HP:0011620)2.16227973
53Postaxial hand polydactyly (HP:0001162)2.14180200
54Abnormality of molar (HP:0011077)2.12948358
55Abnormality of molar morphology (HP:0011070)2.12948358
56Abnormality of the dental pulp (HP:0006479)2.06332648
57Bifid tongue (HP:0010297)2.06160929
58Sclerocornea (HP:0000647)2.03942308
59Atelectasis (HP:0100750)2.02206988
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9712340
61* Abnormal respiratory motile cilium physiology (HP:0012261)11.9215560
62* Abnormal ciliary motility (HP:0012262)11.4538291
63Aplasia/Hypoplasia of the lens (HP:0008063)1.99490844
64Bell-shaped thorax (HP:0001591)1.98810765
65Anencephaly (HP:0002323)1.89824218
66Tubulointerstitial abnormality (HP:0001969)1.88136110
67Recurrent bronchitis (HP:0002837)1.87618459
68* Recurrent sinusitis (HP:0011108)1.80167342
69Furrowed tongue (HP:0000221)1.78016652
70Stage 5 chronic kidney disease (HP:0003774)1.76712444
71Ectopic anus (HP:0004397)1.75657895
72Absent frontal sinuses (HP:0002688)1.75161550
73Decreased circulating renin level (HP:0003351)1.71641311
74Tubular atrophy (HP:0000092)1.70925855
75Fibular hypoplasia (HP:0003038)1.69417454
76Oculomotor apraxia (HP:0000657)1.68945233
77Specific learning disability (HP:0001328)1.68332158
78Renal salt wasting (HP:0000127)1.65225007
79Hypotelorism (HP:0000601)1.60807938
80Hyperthyroidism (HP:0000836)1.57511139
81Back pain (HP:0003418)1.55587047
82Bronchomalacia (HP:0002780)1.53777829
83Nephropathy (HP:0000112)1.48975354
84Omphalocele (HP:0001539)1.48124326
85Hyperkalemia (HP:0002153)1.47943523
86Asplenia (HP:0001746)1.47133165
87Neonatal short-limb short stature (HP:0008921)1.45060134
88Male infertility (HP:0003251)1.43543964
89Polycystic kidney dysplasia (HP:0000113)1.43069016
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42093840
91Limb dystonia (HP:0002451)1.38142121
92Febrile seizures (HP:0002373)1.38124889
93Tubulointerstitial fibrosis (HP:0005576)1.36098548
94Hypodontia (HP:0000668)1.35930381
95Hyperaldosteronism (HP:0000859)1.35529748
96Broad foot (HP:0001769)1.34681611
97Aganglionic megacolon (HP:0002251)1.34679602
98Retinitis pigmentosa (HP:0000510)1.33138587
99Narrow forehead (HP:0000341)1.31509053
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.31358215
101Short thorax (HP:0010306)1.29774178
102Abnormal drinking behavior (HP:0030082)1.28004977
103Polydipsia (HP:0001959)1.28004977
104Central scotoma (HP:0000603)1.27754829
105Tachypnea (HP:0002789)1.27159902
106Anophthalmia (HP:0000528)1.26701799
107Abnormality of macular pigmentation (HP:0008002)1.26382750
108Hyperactive renin-angiotensin system (HP:0000841)1.25963316
109Short foot (HP:0001773)1.25809797
110Abnormality of renin-angiotensin system (HP:0000847)1.25223506
111Decreased central vision (HP:0007663)1.24942352
112Bifid scrotum (HP:0000048)1.24271472
113Obstructive lung disease (HP:0006536)1.24269300
114Cone-rod dystrophy (HP:0000548)1.23964183
115Abnormality of chloride homeostasis (HP:0011422)1.20237527
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.19372266
117Abnormality of the renal cortex (HP:0011035)1.15027042
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.13136886
119Short nail (HP:0001799)1.12805268
120Abnormality of the frontal sinuses (HP:0002687)1.11551644
121Hypokalemic alkalosis (HP:0001949)1.10220299
122Prominent nasal bridge (HP:0000426)1.07923444
123Hip dysplasia (HP:0001385)1.04645644
124Fetal akinesia sequence (HP:0001989)1.04157487
125Absent speech (HP:0001344)1.01157465
126Limb-girdle muscle atrophy (HP:0003797)1.00587744
127Multicystic kidney dysplasia (HP:0000003)1.00211620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.52567916
2PNCK6.09796825
3CASK2.50162370
4MST42.41090935
5NTRK22.22143816
6MAPKAPK32.06275123
7GRK12.03350278
8ERBB32.03020232
9NME11.95766980
10BMPR21.95756747
11MAP3K91.91943388
12NTRK31.87154532
13MARK11.73726548
14MAP3K21.70814228
15DAPK21.66413221
16PTK2B1.59037464
17TTK1.49355878
18IRAK11.40573492
19PRPF4B1.40347449
20TSSK61.37281120
21ADRBK21.34622264
22PHKG21.29271999
23PHKG11.29271999
24BRSK21.27942421
25PLK21.26791843
26MINK11.23956032
27IRAK21.22293673
28MAP2K71.18400936
29EPHB11.17878970
30GRK51.17479538
31MAPK131.15905655
32PRKCG1.12498471
33ARAF1.12432988
34PAK31.10216551
35CDK31.09876237
36EPHA31.07204410
37LRRK21.05254292
38VRK11.00216784
39EEF2K1.00087490
40GRK70.96926384
41MAP3K70.94966425
42CAMK2B0.93962125
43SMG10.90977735
44CAMK2A0.90868823
45STK240.90034627
46BCR0.89835300
47MAP3K30.88639029
48CAMKK20.88085762
49PRKCE0.86131773
50EPHA40.82363473
51RPS6KA20.80237458
52DYRK1A0.79904770
53STK38L0.78671020
54TNIK0.77854826
55ERBB20.76862634
56CAMK1G0.74831043
57CAMK2D0.74571081
58TLK10.74463590
59MKNK20.72122438
60SIK30.71724962
61MAP3K40.71033051
62MAP2K40.71021044
63FER0.71015816
64SIK10.70151720
65LMTK20.69473089
66SIK20.69377172
67STK100.69229530
68ROCK20.67904536
69MARK20.66986059
70MAP2K20.65830172
71ROCK10.65103955
72SGK20.64513751
73PASK0.64218583
74CAMK2G0.64154065
75AKT30.63433139
76PRKCI0.62271588
77MAP3K120.62173841
78ADRBK10.61600991
79MAPKAPK50.58397830
80STK160.57962175
81DYRK1B0.55075340
82CDC42BPA0.54328736
83GSK3A0.53066858
84STK380.52320591
85MST1R0.52054018
86TYRO30.52009656
87SGK2230.50598164
88SGK4940.50598164
89PRKACA0.50465631
90PRKG10.49795772
91FGR0.48544665
92NEK60.48544158
93WNK30.47596290
94FES0.45888029
95NEK90.45327991
96MYLK0.45280959
97PAK20.45272691
98EPHA20.45084239
99BMPR1B0.44997842
100CDK50.44838152
101PINK10.43572165
102TNK20.43538664
103MAPK70.43483891
104OBSCN0.43206559
105ACVR1B0.40873964
106BRAF0.40821476
107TBK10.40526690
108AURKA0.39890851
109PRKACG0.39843047
110TESK10.39770642
111FRK0.39744015
112DYRK30.39276773
113PIM20.38745644
114LATS10.38558877
115UHMK10.37588206
116HIPK20.36991933
117CSK0.36635042
118SGK10.36486191
119DYRK20.36152919
120CAMKK10.36138630
121NTRK10.35916318
122MOS0.34721447
123PRKAA20.33713915
124DAPK10.33550836
125PRKCQ0.33362418
126PRKCD0.32895058
127NLK0.32819116
128MAPK100.32637340
129INSRR0.31369742
130PKN10.30259424
131AKT20.29757110
132MUSK0.29260305
133WEE10.29252857
134FGFR30.29137130
135PRKCZ0.29112931
136PLK10.29063294
137SRC0.28849267
138TRPM70.28582817
139PRKCA0.28546510
140ICK0.28416375
141MAPK120.28376754
142CCNB10.24441500
143RPS6KB20.23202145
144STK110.18213588
145ABL10.18087759
146CHUK0.16145696
147PRKDC0.15009509
148MET0.14782709
149CDK190.13889666
150PTK60.13788102
151PBK0.13746203
152WNK40.11447109

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.55152206
2Olfactory transduction_Homo sapiens_hsa047404.00614156
3beta-Alanine metabolism_Homo sapiens_hsa004103.01841886
4Nicotine addiction_Homo sapiens_hsa050332.98046146
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52891247
6GABAergic synapse_Homo sapiens_hsa047272.32155879
7Caffeine metabolism_Homo sapiens_hsa002322.29280456
8Phototransduction_Homo sapiens_hsa047442.28601356
9Taste transduction_Homo sapiens_hsa047422.24700703
10Huntingtons disease_Homo sapiens_hsa050162.04592298
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02731671
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95972953
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91650138
14Linoleic acid metabolism_Homo sapiens_hsa005911.89757046
15Synaptic vesicle cycle_Homo sapiens_hsa047211.84498481
16Morphine addiction_Homo sapiens_hsa050321.84255720
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.79580108
18Collecting duct acid secretion_Homo sapiens_hsa049661.76356408
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70833680
20Circadian entrainment_Homo sapiens_hsa047131.70511035
21Glutamatergic synapse_Homo sapiens_hsa047241.67608764
22Amphetamine addiction_Homo sapiens_hsa050311.65945849
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.64082256
24Insulin secretion_Homo sapiens_hsa049111.63606023
25Sulfur metabolism_Homo sapiens_hsa009201.59779626
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58550054
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58406313
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56912468
29Gastric acid secretion_Homo sapiens_hsa049711.54342226
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.50113710
31Serotonergic synapse_Homo sapiens_hsa047261.47106345
32Type I diabetes mellitus_Homo sapiens_hsa049401.43808038
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.43605198
34ABC transporters_Homo sapiens_hsa020101.42744459
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39504058
36Oxidative phosphorylation_Homo sapiens_hsa001901.34713027
37Tight junction_Homo sapiens_hsa045301.34554375
38Butanoate metabolism_Homo sapiens_hsa006501.33377620
39Peroxisome_Homo sapiens_hsa041461.32890810
40Cocaine addiction_Homo sapiens_hsa050301.31142225
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28740893
42Salivary secretion_Homo sapiens_hsa049701.28564168
43Prion diseases_Homo sapiens_hsa050201.28507451
44Dopaminergic synapse_Homo sapiens_hsa047281.23338494
45Rheumatoid arthritis_Homo sapiens_hsa053231.21243527
46Fatty acid degradation_Homo sapiens_hsa000711.17219080
47Calcium signaling pathway_Homo sapiens_hsa040201.15777110
48Ovarian steroidogenesis_Homo sapiens_hsa049131.15520656
49Renin secretion_Homo sapiens_hsa049241.12769909
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12142972
51Vibrio cholerae infection_Homo sapiens_hsa051101.10651923
52cAMP signaling pathway_Homo sapiens_hsa040241.07751176
53Chemical carcinogenesis_Homo sapiens_hsa052041.07708462
54Basal cell carcinoma_Homo sapiens_hsa052171.05514081
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04226824
56Alzheimers disease_Homo sapiens_hsa050100.99790959
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99651442
58Cholinergic synapse_Homo sapiens_hsa047250.99408694
59Estrogen signaling pathway_Homo sapiens_hsa049150.99300511
60Allograft rejection_Homo sapiens_hsa053300.98078241
61Autoimmune thyroid disease_Homo sapiens_hsa053200.95509071
62Thyroid hormone synthesis_Homo sapiens_hsa049180.93778029
63Notch signaling pathway_Homo sapiens_hsa043300.93193645
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92075312
65Histidine metabolism_Homo sapiens_hsa003400.91490870
66PPAR signaling pathway_Homo sapiens_hsa033200.88453167
67Vitamin B6 metabolism_Homo sapiens_hsa007500.88211111
68Long-term potentiation_Homo sapiens_hsa047200.87104494
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84104746
70Ether lipid metabolism_Homo sapiens_hsa005650.83312587
71Parkinsons disease_Homo sapiens_hsa050120.82003415
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81899911
73Retinol metabolism_Homo sapiens_hsa008300.81896845
74Circadian rhythm_Homo sapiens_hsa047100.81504409
75Starch and sucrose metabolism_Homo sapiens_hsa005000.78445966
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77751281
77Mineral absorption_Homo sapiens_hsa049780.76995224
78Bile secretion_Homo sapiens_hsa049760.72750281
79Melanogenesis_Homo sapiens_hsa049160.72001533
80GnRH signaling pathway_Homo sapiens_hsa049120.71948660
81Graft-versus-host disease_Homo sapiens_hsa053320.71045561
82Phagosome_Homo sapiens_hsa041450.70925776
83Long-term depression_Homo sapiens_hsa047300.69353562
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68989406
85Staphylococcus aureus infection_Homo sapiens_hsa051500.68048403
86Cardiac muscle contraction_Homo sapiens_hsa042600.67438019
87Choline metabolism in cancer_Homo sapiens_hsa052310.67008035
88Oxytocin signaling pathway_Homo sapiens_hsa049210.64762923
89African trypanosomiasis_Homo sapiens_hsa051430.64464094
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61831509
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59582322
92Axon guidance_Homo sapiens_hsa043600.58852737
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58845631
94Hedgehog signaling pathway_Homo sapiens_hsa043400.58810472
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.58027865
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57057606
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55952257
98Tyrosine metabolism_Homo sapiens_hsa003500.55715888
99Dorso-ventral axis formation_Homo sapiens_hsa043200.54116899
100Arachidonic acid metabolism_Homo sapiens_hsa005900.53799362
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.53669960
102Steroid biosynthesis_Homo sapiens_hsa001000.52058060
103Complement and coagulation cascades_Homo sapiens_hsa046100.51833950
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51359941
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51239929
106Dilated cardiomyopathy_Homo sapiens_hsa054140.50095343
107Sphingolipid metabolism_Homo sapiens_hsa006000.49585294
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.49106493
109Tryptophan metabolism_Homo sapiens_hsa003800.48867101
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.46250985
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43555633
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42855907
113Nitrogen metabolism_Homo sapiens_hsa009100.41851461
114Wnt signaling pathway_Homo sapiens_hsa043100.40597532
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40191293
116Hippo signaling pathway_Homo sapiens_hsa043900.39536661
117Pancreatic secretion_Homo sapiens_hsa049720.39371879
118Metabolic pathways_Homo sapiens_hsa011000.37709812
119Adherens junction_Homo sapiens_hsa045200.37571869
120Hepatitis C_Homo sapiens_hsa051600.37248455
121Glutathione metabolism_Homo sapiens_hsa004800.36871765
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.36801132
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.36399462
124Gap junction_Homo sapiens_hsa045400.35956245
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35352254
126Arginine and proline metabolism_Homo sapiens_hsa003300.34388528
127Glycerolipid metabolism_Homo sapiens_hsa005610.32750796
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31550803
129Vitamin digestion and absorption_Homo sapiens_hsa049770.31475803
130Ras signaling pathway_Homo sapiens_hsa040140.31077324
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30447314
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27014915
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24951516
134Regulation of autophagy_Homo sapiens_hsa041400.18656254
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.11212265
136Pyruvate metabolism_Homo sapiens_hsa006200.10190494
137Hematopoietic cell lineage_Homo sapiens_hsa046400.09614185
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08616457
139Propanoate metabolism_Homo sapiens_hsa006400.08287876
140Lysosome_Homo sapiens_hsa041420.07468667
141Amoebiasis_Homo sapiens_hsa051460.06391217
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06192568
143Protein export_Homo sapiens_hsa030600.05617261

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