RSPO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.04618598
2lateral sprouting from an epithelium (GO:0060601)6.02391192
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.74332189
4mesenchymal-epithelial cell signaling (GO:0060638)5.65923884
5cell proliferation involved in metanephros development (GO:0072203)5.64324066
6epithelial cilium movement (GO:0003351)5.33727336
7intraciliary transport (GO:0042073)5.32355189
8daunorubicin metabolic process (GO:0044597)5.08404611
9polyketide metabolic process (GO:0030638)5.08404611
10doxorubicin metabolic process (GO:0044598)5.08404611
11cell proliferation involved in kidney development (GO:0072111)4.93425300
12mesonephros development (GO:0001823)4.86374972
13response to pheromone (GO:0019236)4.84946996
14craniofacial suture morphogenesis (GO:0097094)4.83325235
15nonmotile primary cilium assembly (GO:0035058)4.81207099
16cellular response to prostaglandin stimulus (GO:0071379)4.61714285
17mesenchymal cell proliferation (GO:0010463)4.55615445
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.50396003
19response to parathyroid hormone (GO:0071107)4.48613606
20cilium movement (GO:0003341)4.48506798
21phenylpropanoid metabolic process (GO:0009698)4.47126156
22sequestering of extracellular ligand from receptor (GO:0035581)4.44331041
23bone trabecula formation (GO:0060346)4.40722638
24neuron fate determination (GO:0048664)4.39475392
25mesenchymal cell differentiation involved in kidney development (GO:0072161)4.35223905
26mesenchymal cell differentiation involved in renal system development (GO:2001012)4.35223905
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.34956168
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.33427762
29metanephric mesenchyme development (GO:0072075)4.31587634
30tongue development (GO:0043586)4.29690564
31regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.17210442
32kidney morphogenesis (GO:0060993)4.15687308
33positive regulation of calcium ion import (GO:0090280)4.14906347
34axonemal dynein complex assembly (GO:0070286)4.12355691
35prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.01573418
36parturition (GO:0007567)3.95004688
37retinal ganglion cell axon guidance (GO:0031290)3.92865368
38regulation of cilium movement (GO:0003352)3.92309588
39lens fiber cell development (GO:0070307)3.91916658
40* regulation of non-canonical Wnt signaling pathway (GO:2000050)3.88179268
41proximal/distal pattern formation (GO:0009954)3.87950109
42head development (GO:0060322)3.86352838
43kidney mesenchyme development (GO:0072074)3.85799028
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.83861752
45positive regulation of catecholamine secretion (GO:0033605)3.83757875
46hindlimb morphogenesis (GO:0035137)3.83176988
47paraxial mesoderm development (GO:0048339)3.79657883
48mesenchymal cell differentiation (GO:0048762)3.79246184
49cartilage morphogenesis (GO:0060536)3.69737117
50cell proliferation in forebrain (GO:0021846)3.69199626
51ribosomal small subunit assembly (GO:0000028)3.67170752
52left/right pattern formation (GO:0060972)3.65980209
53synaptic vesicle docking involved in exocytosis (GO:0016081)3.65926625
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.63671481
55extracellular regulation of signal transduction (GO:1900115)3.60997021
56extracellular negative regulation of signal transduction (GO:1900116)3.60997021
57convergent extension (GO:0060026)3.60691878
58outer ear morphogenesis (GO:0042473)3.59043731
59embryonic hindlimb morphogenesis (GO:0035116)3.57734030
60germ cell migration (GO:0008354)3.53956499
61embryonic skeletal joint morphogenesis (GO:0060272)3.52570640
62response to prostaglandin E (GO:0034695)3.51020302
63embryonic cranial skeleton morphogenesis (GO:0048701)3.49375256
64prostate gland growth (GO:0060736)3.47436011
65branching involved in salivary gland morphogenesis (GO:0060445)3.47096866
66artery smooth muscle contraction (GO:0014824)3.42192138
67striatum development (GO:0021756)3.41502268
68thalamus development (GO:0021794)3.39727701
69neuron projection extension involved in neuron projection guidance (GO:1902284)3.37483463
70axon extension involved in axon guidance (GO:0048846)3.37483463
71embryonic limb morphogenesis (GO:0030326)3.36790394
72embryonic appendage morphogenesis (GO:0035113)3.36790394
73cell differentiation involved in kidney development (GO:0061005)3.34892892
74embryonic forelimb morphogenesis (GO:0035115)3.34117000
75cilium morphogenesis (GO:0060271)3.33232315
76negative regulation of multicellular organism growth (GO:0040015)3.33086108
77body morphogenesis (GO:0010171)3.32902598
78tonic smooth muscle contraction (GO:0014820)3.31554288
79cornea development in camera-type eye (GO:0061303)3.30070284
80substrate-independent telencephalic tangential migration (GO:0021826)3.29141809
81substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.29141809
82transmission of nerve impulse (GO:0019226)3.28666030
83positive regulation of amine transport (GO:0051954)3.28453483
84positive regulation of amino acid transport (GO:0051957)3.27050360
85locomotory exploration behavior (GO:0035641)3.26891652
86viral transcription (GO:0019083)3.26235160
87midbrain development (GO:0030901)3.26178542
88regulation of axon guidance (GO:1902667)3.25689020
89dorsal/ventral pattern formation (GO:0009953)3.25208188
90metanephros development (GO:0001656)3.24743781
91negative regulation of osteoblast proliferation (GO:0033689)3.24669966
92pattern specification involved in kidney development (GO:0061004)3.23436025
93ganglion development (GO:0061548)3.21074579
94acrosome assembly (GO:0001675)3.18108332
95regulation of glomerulus development (GO:0090192)3.15327692
96calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.13641869
97dentate gyrus development (GO:0021542)3.11269647
98negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.10840913
99limb morphogenesis (GO:0035108)3.10190250
100appendage morphogenesis (GO:0035107)3.10190250
101cranial suture morphogenesis (GO:0060363)3.09495129
102otic vesicle formation (GO:0030916)3.09445335
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.08991248
104translational termination (GO:0006415)3.08503204
105lung-associated mesenchyme development (GO:0060484)3.07299306
106smoothened signaling pathway (GO:0007224)3.07290812
107positive regulation of gastrulation (GO:2000543)3.05664395
108neuronal stem cell maintenance (GO:0097150)3.05652519
109post-embryonic morphogenesis (GO:0009886)3.04798380
110negative regulation of stem cell proliferation (GO:2000647)3.03482292
111radial glial cell differentiation (GO:0060019)3.02557330
112somite development (GO:0061053)3.00941863
113organ induction (GO:0001759)3.00924847
114lateral ventricle development (GO:0021670)2.99710961
115white fat cell differentiation (GO:0050872)2.99317564
116forelimb morphogenesis (GO:0035136)2.98016433
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.96632751
118G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95854440
119mesenchymal to epithelial transition (GO:0060231)2.95240630
120limb bud formation (GO:0060174)2.94468916
121regulation of establishment of planar polarity (GO:0090175)2.93919949
122regulation of translation, ncRNA-mediated (GO:0045974)2.93801997
123negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93801997
124negative regulation of translation, ncRNA-mediated (GO:0040033)2.93801997
125cilium organization (GO:0044782)2.93293925
126glial cell migration (GO:0008347)2.92540252
127cilium assembly (GO:0042384)2.92518252
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.92290985
129negative regulation of fibroblast apoptotic process (GO:2000270)2.92189394
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92056774
131synaptic transmission, dopaminergic (GO:0001963)2.90049105
132regulation of organ formation (GO:0003156)2.89197140
133negative regulation of catenin import into nucleus (GO:0035414)2.89066085
134motile cilium assembly (GO:0044458)2.88190526
135sympathetic nervous system development (GO:0048485)2.87731798
136short-term memory (GO:0007614)2.85689187
137mesenchyme morphogenesis (GO:0072132)2.85231514
138branching involved in ureteric bud morphogenesis (GO:0001658)2.84377856
139negative regulation of smoothened signaling pathway (GO:0045879)2.83131546
140regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.82655337
141aminoglycoside antibiotic metabolic process (GO:0030647)2.82563216
142cotranslational protein targeting to membrane (GO:0006613)2.82494219
143hematopoietic stem cell proliferation (GO:0071425)2.82130760
144epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.81106023
145axon ensheathment in central nervous system (GO:0032291)2.80334647
146central nervous system myelination (GO:0022010)2.80334647
147regulation of smoothened signaling pathway (GO:0008589)2.80133036
148glucocorticoid biosynthetic process (GO:0006704)2.79629592
149regulation of morphogenesis of a branching structure (GO:0060688)2.77698379
150spinal cord development (GO:0021510)2.77287622
151retinal rod cell development (GO:0046548)2.76930216
152spinal cord association neuron differentiation (GO:0021527)2.76771451
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76003038
154hypothalamus development (GO:0021854)2.75147277
155regulation of gonadotropin secretion (GO:0032276)2.74391859
156positive regulation of digestive system process (GO:0060456)2.74085062
157negative regulation of metanephros development (GO:0072217)2.73617943
158embryonic skeletal system morphogenesis (GO:0048704)2.73332374
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72228598
160regulation of glucocorticoid secretion (GO:2000849)2.71148603
161somatic stem cell division (GO:0048103)2.71067425
162anatomical structure regression (GO:0060033)2.70085379
163protein targeting to ER (GO:0045047)2.69004416
164camera-type eye morphogenesis (GO:0048593)2.68879503
165negative regulation of chondrocyte differentiation (GO:0032331)2.68874000
166digestive tract morphogenesis (GO:0048546)2.68659729
167chondrocyte differentiation (GO:0002062)2.68458250
168cell differentiation involved in metanephros development (GO:0072202)2.68403078
169inner ear receptor stereocilium organization (GO:0060122)2.68368953
170regulation of keratinocyte proliferation (GO:0010837)2.67630891
171branching involved in prostate gland morphogenesis (GO:0060442)2.67042985
172negative regulation of kidney development (GO:0090185)2.65666253
173regulation of monocyte chemotaxis (GO:0090025)2.64663713
174cardiovascular system development (GO:0072358)2.64621891
175centriole replication (GO:0007099)2.64493049
176resolution of meiotic recombination intermediates (GO:0000712)2.63985982
177photoreceptor cell maintenance (GO:0045494)2.62801977
178regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.62487964
179positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62408116
180negative regulation of axon guidance (GO:1902668)2.61195926
181regulation of dopamine secretion (GO:0014059)2.60632460
182appendage development (GO:0048736)2.58171471
183limb development (GO:0060173)2.58171471
184establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57114939
185translational elongation (GO:0006414)2.54459504
186establishment of planar polarity (GO:0001736)2.53638795

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.42190567
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.37146069
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.01587555
4* EED_16625203_ChIP-ChIP_MESCs_Mouse3.63794930
5GBX2_23144817_ChIP-Seq_PC3_Human3.26647721
6* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.09264696
7EZH2_27304074_Chip-Seq_ESCs_Mouse3.07061709
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.05089113
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.05089113
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01811438
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98524747
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97640902
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.92471597
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82372780
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73928354
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.70123283
17ZNF274_21170338_ChIP-Seq_K562_Hela2.50423287
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49989501
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43852471
20TAF15_26573619_Chip-Seq_HEK293_Human2.37387599
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34208855
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.33961795
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.28232244
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24707457
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21849411
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.13167951
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01544113
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92769827
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.89728470
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88352120
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87270704
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86366954
33P300_19829295_ChIP-Seq_ESCs_Human1.71880651
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70544534
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.67481658
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65571514
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62780616
38AR_21572438_ChIP-Seq_LNCaP_Human1.57903701
39IRF1_19129219_ChIP-ChIP_H3396_Human1.55267087
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54582238
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52175287
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52043814
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.49404065
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47931100
45SMAD4_21799915_ChIP-Seq_A2780_Human1.47274254
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.44817628
47RXR_22108803_ChIP-Seq_LS180_Human1.44591855
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43561778
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.41822257
50DROSHA_22980978_ChIP-Seq_HELA_Human1.40511771
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40457371
52BCAT_22108803_ChIP-Seq_LS180_Human1.38124205
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38026664
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.37268407
55FUS_26573619_Chip-Seq_HEK293_Human1.35798012
56VDR_22108803_ChIP-Seq_LS180_Human1.34818851
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.33861741
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31653622
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31627433
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.31397049
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31184253
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.29278345
63TP53_18474530_ChIP-ChIP_U2OS_Human1.28858590
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27860254
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27860254
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26754676
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26278588
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.26189944
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25942475
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25834443
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.25310384
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24946506
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24763830
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23023346
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22769990
76RNF2_27304074_Chip-Seq_NSC_Mouse1.22594537
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21961971
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.21845985
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21403467
80* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18804938
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17794905
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17041032
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16116447
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.15707604
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15031525
86AR_25329375_ChIP-Seq_VCAP_Human1.11885966
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10299036
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.10058982
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.08318701
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07595026
91RUNX2_22187159_ChIP-Seq_PCA_Human1.06353026
92AR_19668381_ChIP-Seq_PC3_Human1.06280385
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06205627
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03579400
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.03420459
96TCF4_22108803_ChIP-Seq_LS180_Human1.03017024
97MYC_18940864_ChIP-ChIP_HL60_Human1.02593543
98AHR_22903824_ChIP-Seq_MCF-7_Human1.02438593
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02177409
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.01931656
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00939376
102TCF4_23295773_ChIP-Seq_U87_Human1.00249596
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99366183
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99237147
105STAT3_23295773_ChIP-Seq_U87_Human0.98440286
106CBP_20019798_ChIP-Seq_JUKART_Human0.98433040
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98433040
108EWS_26573619_Chip-Seq_HEK293_Human0.98382239
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98301245
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96803061
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96316067
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96305570
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96039508
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95561235
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95112835
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94803192
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94249420
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.94184981
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93259228
120REST_21632747_ChIP-Seq_MESCs_Mouse0.92522260
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.92153725
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.91769792
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91654492
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91537231
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91382363
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90825647
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90705881
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.90458242
129IGF1R_20145208_ChIP-Seq_DFB_Human0.90014675
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88030098
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87861296
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87729622
133SOX9_26525672_Chip-Seq_HEART_Mouse0.87583707
134SOX2_19829295_ChIP-Seq_ESCs_Human0.87496240
135NANOG_19829295_ChIP-Seq_ESCs_Human0.87496240
136ER_23166858_ChIP-Seq_MCF-7_Human0.87243899
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.84485268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.99464569
2MP0003123_paternal_imprinting3.97398983
3MP0005503_abnormal_tendon_morphology3.66875627
4MP0002653_abnormal_ependyma_morphology3.47970807
5MP0008789_abnormal_olfactory_epithelium3.08284550
6MP0002938_white_spotting2.99048801
7MP0005645_abnormal_hypothalamus_physiol2.92691322
8MP0003787_abnormal_imprinting2.89090938
9MP0010030_abnormal_orbit_morphology2.85522067
10MP0003121_genomic_imprinting2.80161822
11MP0000566_synostosis2.77528894
12MP0003942_abnormal_urinary_system2.60070723
13MP0005499_abnormal_olfactory_system2.50809659
14MP0005394_taste/olfaction_phenotype2.50809659
15MP0009278_abnormal_bone_marrow2.47858573
16MP0009250_abnormal_appendicular_skeleto2.42797244
17MP0003385_abnormal_body_wall2.35319448
18MP0006276_abnormal_autonomic_nervous2.13600457
19MP0003880_abnormal_central_pattern2.10118497
20MP0002638_abnormal_pupillary_reflex2.07517827
21MP0001984_abnormal_olfaction2.07256804
22MP0000049_abnormal_middle_ear2.04226112
23MP0002102_abnormal_ear_morphology1.95251454
24MP0004272_abnormal_basement_membrane1.95056790
25MP0009379_abnormal_foot_pigmentation1.93326228
26MP0001299_abnormal_eye_distance/1.91179329
27MP0000534_abnormal_ureter_morphology1.86428164
28MP0005248_abnormal_Harderian_gland1.71221212
29MP0008438_abnormal_cutaneous_collagen1.69544987
30MP0000428_abnormal_craniofacial_morphol1.68759886
31MP0001293_anophthalmia1.63402392
32MP0005377_hearing/vestibular/ear_phenot1.59901548
33MP0003878_abnormal_ear_physiology1.59901548
34MP0000762_abnormal_tongue_morphology1.58855397
35MP0001968_abnormal_touch/_nociception1.58581710
36MP0002234_abnormal_pharynx_morphology1.58156141
37MP0000372_irregular_coat_pigmentation1.56495376
38MP0003941_abnormal_skin_development1.53241564
39MP0002108_abnormal_muscle_morphology1.47890480
40MP0000427_abnormal_hair_cycle1.46499750
41MP0000026_abnormal_inner_ear1.46414897
42MP0002116_abnormal_craniofacial_bone1.46235779
43MP0002249_abnormal_larynx_morphology1.44630249
44MP0003646_muscle_fatigue1.40438677
45MP0004134_abnormal_chest_morphology1.38816514
46MP0001286_abnormal_eye_development1.38226594
47MP0005551_abnormal_eye_electrophysiolog1.37990567
48MP0003935_abnormal_craniofacial_develop1.37335167
49MP0000569_abnormal_digit_pigmentation1.37113447
50MP0003755_abnormal_palate_morphology1.36465730
51MP0002109_abnormal_limb_morphology1.34706402
52MP0001270_distended_abdomen1.30838007
53MP0003938_abnormal_ear_development1.29631185
54MP0005187_abnormal_penis_morphology1.29531211
55MP0002295_abnormal_pulmonary_circulatio1.29269460
56MP0001661_extended_life_span1.28985590
57MP0003136_yellow_coat_color1.21158393
58MP0008877_abnormal_DNA_methylation1.20866049
59MP0002735_abnormal_chemical_nociception1.20804950
60MP0002751_abnormal_autonomic_nervous1.20784777
61MP0004133_heterotaxia1.20664383
62MP0005275_abnormal_skin_tensile1.20308397
63MP0002697_abnormal_eye_size1.18867256
64MP0005391_vision/eye_phenotype1.18421125
65MP0003937_abnormal_limbs/digits/tail_de1.18123959
66MP0002932_abnormal_joint_morphology1.17442569
67MP0002115_abnormal_skeleton_extremities1.16986503
68MP0000678_abnormal_parathyroid_gland1.16007722
69MP0000537_abnormal_urethra_morphology1.14770988
70MP0005257_abnormal_intraocular_pressure1.14434493
71MP0001346_abnormal_lacrimal_gland1.13454233
72MP0005508_abnormal_skeleton_morphology1.11652615
73MP0005171_absent_coat_pigmentation1.11485677
74MP0002282_abnormal_trachea_morphology1.10910025
75MP0000751_myopathy1.10654473
76MP0004142_abnormal_muscle_tone1.10379520
77MP0010386_abnormal_urinary_bladder1.10204324
78MP0000163_abnormal_cartilage_morphology1.10157505
79MP0006072_abnormal_retinal_apoptosis1.09712016
80MP0009672_abnormal_birth_weight1.09624460
81MP0002736_abnormal_nociception_after1.09129886
82MP0002837_dystrophic_cardiac_calcinosis1.08921184
83MP0000003_abnormal_adipose_tissue1.07367021
84MP0005646_abnormal_pituitary_gland1.05459699
85MP0001529_abnormal_vocalization1.05298781
86MP0005195_abnormal_posterior_eye1.05085197
87MP0001324_abnormal_eye_pigmentation1.04772008
88MP0009780_abnormal_chondrocyte_physiolo1.03634988
89MP0005253_abnormal_eye_physiology1.03576819
90MP0002233_abnormal_nose_morphology1.00583885
91MP0002177_abnormal_outer_ear1.00256405
92MP0001177_atelectasis1.00237334
93MP0008004_abnormal_stomach_pH0.97610908
94MP0001340_abnormal_eyelid_morphology0.97377034
95MP0003861_abnormal_nervous_system0.95143582
96MP0009053_abnormal_anal_canal0.95088008
97MP0000516_abnormal_urinary_system0.94735280
98MP0005367_renal/urinary_system_phenotyp0.94735280
99MP0003119_abnormal_digestive_system0.94366836
100MP0009703_decreased_birth_body0.94085794
101MP0000432_abnormal_head_morphology0.92214152
102MP0001502_abnormal_circadian_rhythm0.90416033
103MP0002557_abnormal_social/conspecific_i0.90403515
104MP0001963_abnormal_hearing_physiology0.89351711
105MP0001188_hyperpigmentation0.89283593
106MP0002752_abnormal_somatic_nervous0.88541963
107MP0002113_abnormal_skeleton_development0.87033204
108MP0009046_muscle_twitch0.86604384
109MP0003959_abnormal_lean_body0.85612968
110MP0004858_abnormal_nervous_system0.85429055
111MP0004130_abnormal_muscle_cell0.84964587
112MP0000639_abnormal_adrenal_gland0.83357358
113MP0000631_abnormal_neuroendocrine_gland0.82207200
114MP0002572_abnormal_emotion/affect_behav0.81730844
115MP0002098_abnormal_vibrissa_morphology0.81726713
116MP0000681_abnormal_thyroid_gland0.79493727
117MP0010368_abnormal_lymphatic_system0.79201779
118MP0003635_abnormal_synaptic_transmissio0.78292668
119MP0006292_abnormal_olfactory_placode0.78264142
120MP0002152_abnormal_brain_morphology0.77108062
121MP0005197_abnormal_uvea_morphology0.76917053
122MP0009697_abnormal_copulation0.76405294
123MP0000579_abnormal_nail_morphology0.76085964
124MP0004147_increased_porphyrin_level0.75509866
125MP0002114_abnormal_axial_skeleton0.75494894
126MP0003890_abnormal_embryonic-extraembry0.74953271
127MP0002092_abnormal_eye_morphology0.74885923
128* MP0003936_abnormal_reproductive_system0.74414203
129MP0000955_abnormal_spinal_cord0.74296367
130MP0001986_abnormal_taste_sensitivity0.73054308
131MP0001485_abnormal_pinna_reflex0.71984724
132MP0003115_abnormal_respiratory_system0.71871673
133MP0004233_abnormal_muscle_weight0.69691838
134MP0000778_abnormal_nervous_system0.69377118
135MP0002163_abnormal_gland_morphology0.69073487
136MP0008995_early_reproductive_senescence0.68962896
137MP0001175_abnormal_lung_morphology0.68774237
138MP0002127_abnormal_cardiovascular_syste0.66940447
139MP0002184_abnormal_innervation0.66436819
140MP0002111_abnormal_tail_morphology0.66159680
141MP0001919_abnormal_reproductive_system0.63442741
142MP0003011_delayed_dark_adaptation0.63283802
143MP0001542_abnormal_bone_strength0.60957408
144MP0002928_abnormal_bile_duct0.59611273
145MP0003632_abnormal_nervous_system0.57466880
146MP0000647_abnormal_sebaceous_gland0.56059758

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)5.94022297
2Midline defect of the nose (HP:0004122)5.43424980
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.30278910
4Short 4th metacarpal (HP:0010044)5.30278910
5True hermaphroditism (HP:0010459)4.12118704
6Nasolacrimal duct obstruction (HP:0000579)4.07728797
7Pancreatic fibrosis (HP:0100732)3.89578054
8Trigonocephaly (HP:0000243)3.88212667
9Abnormality of the 4th metacarpal (HP:0010012)3.80528638
10Broad metatarsal (HP:0001783)3.75527236
11Nuclear cataract (HP:0100018)3.71088439
12Abnormality of midbrain morphology (HP:0002418)3.64722943
13Molar tooth sign on MRI (HP:0002419)3.64722943
14Nephronophthisis (HP:0000090)3.52963307
15Abnormal ciliary motility (HP:0012262)3.48842333
16Pancreatic cysts (HP:0001737)3.48710751
17Abnormality of the nasolacrimal system (HP:0000614)3.43292300
18Abnormality of the lacrimal duct (HP:0011481)3.42928255
19Enlarged penis (HP:0000040)3.40222751
20Medial flaring of the eyebrow (HP:0010747)3.31986789
21Septo-optic dysplasia (HP:0100842)3.30302622
22Congenital primary aphakia (HP:0007707)3.30128364
23Abnormal respiratory epithelium morphology (HP:0012253)3.29807742
24Abnormal respiratory motile cilium morphology (HP:0005938)3.29807742
25Shallow orbits (HP:0000586)3.27106293
26Gait imbalance (HP:0002141)3.26799748
27Abnormality of the nasal septum (HP:0000419)3.23513234
28Absent/shortened dynein arms (HP:0200106)3.16806592
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.16806592
30Coronal craniosynostosis (HP:0004440)3.12831853
31Zonular cataract (HP:0010920)3.04289921
32Hypoventilation (HP:0002791)3.03749226
33Neoplasm of the heart (HP:0100544)3.03360846
34Aplasia/Hypoplasia of the tongue (HP:0010295)3.00356386
35Abnormality of the labia minora (HP:0012880)2.97188956
36Abnormality of the diencephalon (HP:0010662)2.96940313
37Follicular hyperkeratosis (HP:0007502)2.96199395
38Recurrent corneal erosions (HP:0000495)2.93106463
39Abnormal respiratory motile cilium physiology (HP:0012261)2.92941090
40Nephrogenic diabetes insipidus (HP:0009806)2.92639535
41Anteriorly placed anus (HP:0001545)2.87912554
42Cystic liver disease (HP:0006706)2.86684561
43Vaginal atresia (HP:0000148)2.83366501
44Abnormality of the renal medulla (HP:0100957)2.80512830
45Genital tract atresia (HP:0001827)2.79494387
46Abnormality of incisor morphology (HP:0011063)2.78190244
47Postaxial foot polydactyly (HP:0001830)2.75490979
48Broad toe (HP:0001837)2.74513301
49Supernumerary ribs (HP:0005815)2.72252232
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.70503671
51Rib fusion (HP:0000902)2.69536072
52Rhinitis (HP:0012384)2.66929177
53Absent eyebrow (HP:0002223)2.66683126
54Oligodactyly (HP:0012165)2.65771388
55Postaxial hand polydactyly (HP:0001162)2.63755807
56Growth hormone deficiency (HP:0000824)2.63486448
57Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.61688291
58Bifid tongue (HP:0010297)2.61685335
59Anencephaly (HP:0002323)2.59211272
60Turricephaly (HP:0000262)2.58630447
61Mesomelia (HP:0003027)2.56181577
62Hyperthyroidism (HP:0000836)2.55456329
63White forelock (HP:0002211)2.55361882
64Poor coordination (HP:0002370)2.54622050
65Sclerocornea (HP:0000647)2.53512993
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.52587933
67Oligodactyly (hands) (HP:0001180)2.52070907
68Supernumerary bones of the axial skeleton (HP:0009144)2.51289432
69Median cleft lip (HP:0000161)2.51228011
70Partial duplication of the phalanx of hand (HP:0009999)2.48271970
71Abdominal situs inversus (HP:0003363)2.46309694
72Abnormality of abdominal situs (HP:0011620)2.46309694
73Aplasia cutis congenita (HP:0001057)2.43647658
74Microglossia (HP:0000171)2.42966255
75Abnormality of the incisor (HP:0000676)2.40986631
76Abnormality of cochlea (HP:0000375)2.40863551
77Down-sloping shoulders (HP:0200021)2.39987148
78Abnormal number of incisors (HP:0011064)2.39875449
79Bell-shaped thorax (HP:0001591)2.38514167
80Broad hallux (HP:0010055)2.38204002
81Aplasia involving bones of the upper limbs (HP:0009823)2.31629960
82Aplasia of the phalanges of the hand (HP:0009802)2.31629960
83Aplasia involving bones of the extremities (HP:0009825)2.31629960
84High anterior hairline (HP:0009890)2.31321497
85Absent eyelashes (HP:0000561)2.30724440
86Anophthalmia (HP:0000528)2.30568643
87Keratoconus (HP:0000563)2.29492509
88Increased corneal curvature (HP:0100692)2.29492509
89Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.28761048
90Patchy hypopigmentation of hair (HP:0011365)2.28433829
91Supernumerary spleens (HP:0009799)2.28293998
92Renal duplication (HP:0000075)2.27467842
93Humeroradial synostosis (HP:0003041)2.26890925
94Synostosis involving the elbow (HP:0003938)2.26890925
95Short metatarsal (HP:0010743)2.26607370
96Narrow nasal bridge (HP:0000446)2.26525875
97Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24798529
98Stenosis of the external auditory canal (HP:0000402)2.23679623
99Narrow palate (HP:0000189)2.23133270
100Alacrima (HP:0000522)2.21743049
101Flat capital femoral epiphysis (HP:0003370)2.21548051
102Congenital hepatic fibrosis (HP:0002612)2.20498972
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19666927
104Hypoplastic pelvis (HP:0008839)2.19363521
105Preaxial hand polydactyly (HP:0001177)2.18700840
106Broad foot (HP:0001769)2.18691288
107Vitreoretinal degeneration (HP:0000655)2.17221336
108Increased number of teeth (HP:0011069)2.17139146
109Holoprosencephaly (HP:0001360)2.15457605
110Congenital stationary night blindness (HP:0007642)2.15297508
111Aplasia/Hypoplasia of the spleen (HP:0010451)2.13396634
112Pulmonary artery stenosis (HP:0004415)2.12667342
113Menstrual irregularities (HP:0000858)2.11376426
114Anterior segment dysgenesis (HP:0007700)2.11024684
115Optic nerve hypoplasia (HP:0000609)2.07914514
116Aplasia/Hypoplasia of the lens (HP:0008063)2.06986758
117Toxemia of pregnancy (HP:0100603)2.06605286
118Partial duplication of thumb phalanx (HP:0009944)2.06126504
119Abnormal eating behavior (HP:0100738)2.05941533
120Accelerated skeletal maturation (HP:0005616)2.05889026
121Absent septum pellucidum (HP:0001331)2.05316283
122Aqueductal stenosis (HP:0002410)2.05238852
123Cutaneous finger syndactyly (HP:0010554)2.05103900
124Rectal fistula (HP:0100590)2.04700168
125Rectovaginal fistula (HP:0000143)2.04700168
126Narrow forehead (HP:0000341)2.02133898
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01304038
128Absent epiphyses (HP:0010577)2.01304038
129Abnormal hair whorl (HP:0010721)2.00285755
130Renal dysplasia (HP:0000110)1.99386261
131Fibular hypoplasia (HP:0003038)1.98809011
132Unilateral renal agenesis (HP:0000122)1.98672096
133Buphthalmos (HP:0000557)1.98142683
134Medulloblastoma (HP:0002885)1.97175865
135Hypoplasia of the maxilla (HP:0000327)1.96116778
136Polyphagia (HP:0002591)1.96062949
137Preaxial foot polydactyly (HP:0001841)1.95174324
138Tubular atrophy (HP:0000092)1.94397022
139Macroorchidism (HP:0000053)1.93459432
140Metaphyseal cupping (HP:0003021)1.93423914
141Decreased testicular size (HP:0008734)1.92621229
142Decreased central vision (HP:0007663)1.92135287
143Chronic hepatic failure (HP:0100626)1.87894800
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.87714603
145Omphalocele (HP:0001539)1.87541700
146Hyperglycinemia (HP:0002154)1.87119031
147Intestinal fistula (HP:0100819)1.86644487
148Type II lissencephaly (HP:0007260)1.86208215
149Asplenia (HP:0001746)1.86000114
150Conical tooth (HP:0000698)1.85895825
151Morphological abnormality of the inner ear (HP:0011390)1.84911657
152Abnormal biliary tract physiology (HP:0012439)1.84634960
153Bile duct proliferation (HP:0001408)1.84634960
154Protruding ear (HP:0000411)1.84202359
155Short tibia (HP:0005736)1.84127102
156Short phalanx of the thumb (HP:0009660)1.83766148
157Exostoses (HP:0100777)1.83520791
158Chorioretinal atrophy (HP:0000533)1.83277204
159Sparse lateral eyebrow (HP:0005338)1.83033329
160Male pseudohermaphroditism (HP:0000037)1.82879598
161Abnormal drinking behavior (HP:0030082)1.82246287
162Polydipsia (HP:0001959)1.82246287
163Broad face (HP:0000283)1.79772594
164Micropenis (HP:0000054)1.78390525
165Aganglionic megacolon (HP:0002251)1.77713572
166Abnormality of cells of the erythroid lineage (HP:0012130)1.77386300
167Maternal diabetes (HP:0009800)1.76932372
168Abnormality of the aortic arch (HP:0012303)1.75036612
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74936886
170Striae distensae (HP:0001065)1.74536861
171Depressed nasal ridge (HP:0000457)1.74076222
172Broad phalanges of the hand (HP:0009768)1.72900778
173Cutaneous syndactyly (HP:0012725)1.72807875
174Short foot (HP:0001773)1.72624344
175Broad distal phalanx of finger (HP:0009836)1.72112684
176Vaginal fistula (HP:0004320)1.70557804
177Decreased lacrimation (HP:0000633)1.69588498
178Focal motor seizures (HP:0011153)1.69090731
179Prominent supraorbital ridges (HP:0000336)1.68483442
180Testicular neoplasm (HP:0010788)1.68139631
181Labial hypoplasia (HP:0000066)1.67659076
182Broad thumb (HP:0011304)1.66592124
183Heterochromia iridis (HP:0001100)1.63579293
184Hyperphosphatemia (HP:0002905)1.63047692
185Hypoplastic labia majora (HP:0000059)1.62886926
186Hypotelorism (HP:0000601)1.62462085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.91378033
2SIK34.75587194
3SIK13.77132196
4LATS13.37214647
5MAPK153.34885962
6DDR22.65654825
7FGFR22.61428395
8SIK22.58788215
9WNK32.34998107
10MAP4K22.28939869
11AKT32.24883443
12NTRK32.16989681
13PRPF4B2.02989183
14EPHB22.02552978
15DAPK22.01789030
16NUAK11.91785913
17PDGFRA1.90757887
18CDK81.90738036
19FGFR11.89248011
20BMPR1B1.88452689
21BCKDK1.86757763
22MAP3K121.82436176
23SGK21.80425456
24TNIK1.78356812
25ZAK1.75771244
26PLK21.73928997
27PLK41.70492127
28CAMK1D1.66148743
29PIK3CG1.64814120
30PNCK1.64006079
31LATS21.60517471
32ERBB31.56702899
33CAMK1G1.54870227
34SGK2231.50579069
35SGK4941.50579069
36EPHA41.47652411
37SGK31.43952978
38MAP3K41.43269650
39PINK11.40823439
40PIK3CA1.40472916
41MAP2K71.36463638
42PKN11.32658031
43TGFBR21.28532638
44STK161.25522900
45GRK11.23938782
46EPHA31.23682859
47DYRK21.19329516
48MAP3K91.18428523
49MAP2K41.18306511
50TLK11.12440881
51DYRK1A1.10687332
52DYRK31.09495033
53FER1.08887638
54TYRO31.05556714
55ARAF1.05355815
56ACVR1B1.05059268
57MKNK11.04341521
58CAMK41.03362820
59TNK20.99939148
60WEE10.97537149
61MAP2K20.97296385
62BMX0.96577284
63TRIB30.95656487
64TAOK20.94451988
65PRKD30.93311892
66WNK40.93185670
67STK38L0.92703130
68MKNK20.90071850
69INSRR0.89988675
70MAPK130.89920025
71BRSK20.88528608
72WNK10.88412592
73TIE10.88345089
74MOS0.86770411
75CAMK10.86001389
76MUSK0.81753408
77DYRK1B0.81687007
78NLK0.80202802
79VRK10.78697404
80PLK10.76786441
81TGFBR10.76737590
82NTRK20.76623766
83STK110.75244827
84MAP3K70.74010868
85AURKB0.73874350
86PRKCE0.72616871
87SGK10.72121575
88VRK20.71975077
89TSSK60.71237227
90CCNB10.71059677
91EIF2AK10.68775679
92GRK50.67324332
93PRKCG0.66795118
94LMTK20.66613955
95PDGFRB0.66228968
96STK390.62363893
97DAPK10.61293915
98TRIM280.60178227
99ADRBK10.60119037
100PHKG20.59820250
101PHKG10.59820250
102PASK0.59311344
103MAPK70.58987400
104CSNK1G10.58191561
105MARK30.57914812
106MAP3K100.57555527
107DAPK30.57268207
108BRD40.56884317
109CSNK1G20.56113945
110DMPK0.53950627
111PRKCH0.52272568
112NTRK10.51309993
113MARK10.51229955
114LRRK20.50379767
115CSNK1A1L0.50046056
116STK30.49784852
117CDK30.49767412
118MARK20.47721494
119BCR0.47453718
120MINK10.47449400
121ATR0.46840472
122NEK90.46494780
123PAK30.46395416
124CSNK1G30.45992114
125NEK20.45385854
126PRKACA0.44617100
127CDK70.44610641
128PAK60.44291764
129RPS6KA60.43845860
130AKT20.43252209
131CDK120.42634849
132RIPK10.42304668
133ADRBK20.41033056
134SRPK10.40829996
135PAK40.39590071
136STK380.38644566
137MYLK0.38495582
138CDK190.38425858
139PRKACB0.36839329
140MAPK80.35915989
141RPS6KA20.35562327
142RPS6KC10.35158576
143RPS6KL10.35158576
144MATK0.33808900
145SRC0.33590497
146IRAK20.32748092
147YES10.32696069
148PRKG10.31270409
149MAP2K60.30965414
150AKT10.30320985
151FRK0.30255941
152CDK50.30127255
153PLK30.28217448
154PRKCZ0.27053664
155RET0.26000431
156CSNK1A10.25068962
157FGFR30.24804473
158MAP3K140.24347682
159INSR0.24320576
160PTK2B0.23760883

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.88983049
2Hedgehog signaling pathway_Homo sapiens_hsa043403.46784056
3Ribosome_Homo sapiens_hsa030103.19018493
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.18555112
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61344938
6Protein export_Homo sapiens_hsa030602.35794824
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.24492427
8Synaptic vesicle cycle_Homo sapiens_hsa047212.19899732
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16771814
10Nicotine addiction_Homo sapiens_hsa050332.09707513
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99129047
12Morphine addiction_Homo sapiens_hsa050321.95824543
13Melanoma_Homo sapiens_hsa052181.94416117
14Renin secretion_Homo sapiens_hsa049241.92566501
15Linoleic acid metabolism_Homo sapiens_hsa005911.91975253
16Wnt signaling pathway_Homo sapiens_hsa043101.90726215
17Steroid biosynthesis_Homo sapiens_hsa001001.88390653
18Folate biosynthesis_Homo sapiens_hsa007901.84719330
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83275179
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80460649
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74269840
22Circadian entrainment_Homo sapiens_hsa047131.67593000
23Oxidative phosphorylation_Homo sapiens_hsa001901.65197056
24Hippo signaling pathway_Homo sapiens_hsa043901.63664517
25Arachidonic acid metabolism_Homo sapiens_hsa005901.62199643
26Melanogenesis_Homo sapiens_hsa049161.60122709
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59460007
28Butanoate metabolism_Homo sapiens_hsa006501.57178394
29Propanoate metabolism_Homo sapiens_hsa006401.56694668
30Cocaine addiction_Homo sapiens_hsa050301.53688298
31Fanconi anemia pathway_Homo sapiens_hsa034601.48861591
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45303455
33Parkinsons disease_Homo sapiens_hsa050121.44060560
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41302442
35Homologous recombination_Homo sapiens_hsa034401.39831513
36Base excision repair_Homo sapiens_hsa034101.39374602
37Amphetamine addiction_Homo sapiens_hsa050311.39257326
38Vibrio cholerae infection_Homo sapiens_hsa051101.38549683
39TGF-beta signaling pathway_Homo sapiens_hsa043501.37520706
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.37141506
41Olfactory transduction_Homo sapiens_hsa047401.36918760
42Axon guidance_Homo sapiens_hsa043601.36857519
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36499076
44Type II diabetes mellitus_Homo sapiens_hsa049301.36466282
45Taste transduction_Homo sapiens_hsa047421.36428000
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35721857
47Nitrogen metabolism_Homo sapiens_hsa009101.34191838
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31754951
49cAMP signaling pathway_Homo sapiens_hsa040241.29315582
50Huntingtons disease_Homo sapiens_hsa050161.27981003
51Ovarian steroidogenesis_Homo sapiens_hsa049131.27780309
52Endometrial cancer_Homo sapiens_hsa052131.26912566
53Cardiac muscle contraction_Homo sapiens_hsa042601.26819520
54Phototransduction_Homo sapiens_hsa047441.25952418
55Dilated cardiomyopathy_Homo sapiens_hsa054141.25201818
56Pathways in cancer_Homo sapiens_hsa052001.24902634
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24878932
58Collecting duct acid secretion_Homo sapiens_hsa049661.22441877
59Cholinergic synapse_Homo sapiens_hsa047251.21152606
60Long-term depression_Homo sapiens_hsa047301.20828855
61GABAergic synapse_Homo sapiens_hsa047271.19490888
62Insulin secretion_Homo sapiens_hsa049111.19306894
63Dopaminergic synapse_Homo sapiens_hsa047281.14838875
64ECM-receptor interaction_Homo sapiens_hsa045121.14001044
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11972641
66Adherens junction_Homo sapiens_hsa045201.11775505
67Serotonergic synapse_Homo sapiens_hsa047261.10188451
68Sulfur relay system_Homo sapiens_hsa041221.09579699
69Colorectal cancer_Homo sapiens_hsa052101.08678897
70Prostate cancer_Homo sapiens_hsa052151.08431206
71Calcium signaling pathway_Homo sapiens_hsa040201.08018749
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07643614
73Basal transcription factors_Homo sapiens_hsa030221.04615216
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04112095
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01735887
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00716935
77Glutamatergic synapse_Homo sapiens_hsa047241.00704556
78Estrogen signaling pathway_Homo sapiens_hsa049151.00599372
79Mismatch repair_Homo sapiens_hsa034301.00017067
80Salivary secretion_Homo sapiens_hsa049700.98390561
81Glioma_Homo sapiens_hsa052140.98279688
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97547400
83Nucleotide excision repair_Homo sapiens_hsa034200.97487903
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97308103
85RNA polymerase_Homo sapiens_hsa030200.96433313
86Alzheimers disease_Homo sapiens_hsa050100.96425004
87Proteoglycans in cancer_Homo sapiens_hsa052050.96015241
88Peroxisome_Homo sapiens_hsa041460.95290165
89Gap junction_Homo sapiens_hsa045400.95040694
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.94951085
91Rap1 signaling pathway_Homo sapiens_hsa040150.93804813
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93319595
93ErbB signaling pathway_Homo sapiens_hsa040120.92965766
94Ether lipid metabolism_Homo sapiens_hsa005650.91909427
95Notch signaling pathway_Homo sapiens_hsa043300.91872291
96Fatty acid elongation_Homo sapiens_hsa000620.90667583
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89595519
98Glutathione metabolism_Homo sapiens_hsa004800.88352954
99GnRH signaling pathway_Homo sapiens_hsa049120.87860446
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87709316
101MAPK signaling pathway_Homo sapiens_hsa040100.87480687
102Chemical carcinogenesis_Homo sapiens_hsa052040.87320385
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86978196
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.85705633
105Oxytocin signaling pathway_Homo sapiens_hsa049210.84930830
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.84288204
107Amoebiasis_Homo sapiens_hsa051460.84055586
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83510710
109Choline metabolism in cancer_Homo sapiens_hsa052310.81925744
110Tryptophan metabolism_Homo sapiens_hsa003800.81851688
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.81405378
112Prolactin signaling pathway_Homo sapiens_hsa049170.81229001
113RNA degradation_Homo sapiens_hsa030180.80837526
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80297105
115Ras signaling pathway_Homo sapiens_hsa040140.79692609
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79262729
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.79008217
118Focal adhesion_Homo sapiens_hsa045100.76920265
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.76269882
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75025468
121Acute myeloid leukemia_Homo sapiens_hsa052210.74641396
122Long-term potentiation_Homo sapiens_hsa047200.73967757
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72475869
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71689330
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71126340
126Protein digestion and absorption_Homo sapiens_hsa049740.70302229
127Glycerolipid metabolism_Homo sapiens_hsa005610.69695256
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68616572
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68407951
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66699757
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65091814
132Insulin signaling pathway_Homo sapiens_hsa049100.63701542
133Thyroid cancer_Homo sapiens_hsa052160.63017442
134Fat digestion and absorption_Homo sapiens_hsa049750.61452773
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60551248
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60429108
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59720982
138beta-Alanine metabolism_Homo sapiens_hsa004100.59704536
139Tyrosine metabolism_Homo sapiens_hsa003500.59347856
140Chronic myeloid leukemia_Homo sapiens_hsa052200.58086137
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.57413411
142Fatty acid degradation_Homo sapiens_hsa000710.56828207
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55145185
144Metabolic pathways_Homo sapiens_hsa011000.54358013
145Gastric acid secretion_Homo sapiens_hsa049710.53973653
146Phagosome_Homo sapiens_hsa041450.53632244
147HTLV-I infection_Homo sapiens_hsa051660.53501106
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53239964
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53197040
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53116421
151Renal cell carcinoma_Homo sapiens_hsa052110.52065464
152Retinol metabolism_Homo sapiens_hsa008300.49805794
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49171755
154MicroRNAs in cancer_Homo sapiens_hsa052060.48965198
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48368753
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46922059
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46439885
158Circadian rhythm_Homo sapiens_hsa047100.43659060
159Non-homologous end-joining_Homo sapiens_hsa034500.40357145
160Bile secretion_Homo sapiens_hsa049760.38624928
161Pyruvate metabolism_Homo sapiens_hsa006200.38596122
162Spliceosome_Homo sapiens_hsa030400.37710460
163Arginine and proline metabolism_Homo sapiens_hsa003300.37370388
164Lysine degradation_Homo sapiens_hsa003100.30805323
165Fatty acid metabolism_Homo sapiens_hsa012120.30654788
166ABC transporters_Homo sapiens_hsa020100.26322179
167DNA replication_Homo sapiens_hsa030300.25277147
168Histidine metabolism_Homo sapiens_hsa003400.23976169
169Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23089769
170N-Glycan biosynthesis_Homo sapiens_hsa005100.21640196
171Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19645700

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