RSPO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.71051545
2piRNA metabolic process (GO:0034587)6.62429277
3negative regulation of axon guidance (GO:1902668)5.35250043
4positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.12667409
5intraciliary transport (GO:0042073)5.00800036
6regulation of meiosis (GO:0040020)4.80797688
7limb bud formation (GO:0060174)4.79734205
8thalamus development (GO:0021794)4.77950167
9positive regulation of gastrulation (GO:2000543)4.63689462
10female gamete generation (GO:0007292)4.56661301
11DNA integration (GO:0015074)4.49196430
12chondrocyte proliferation (GO:0035988)4.36240435
13negative regulation of vascular permeability (GO:0043116)4.30738828
14mitotic chromosome condensation (GO:0007076)4.29086861
15midbrain development (GO:0030901)4.29021172
16histone H2A monoubiquitination (GO:0035518)4.28561978
17positive regulation of fibroblast migration (GO:0010763)4.24830285
18transmission of nerve impulse (GO:0019226)4.18946795
19mitotic metaphase plate congression (GO:0007080)4.16580340
20branching involved in labyrinthine layer morphogenesis (GO:0060670)4.14790691
21histone H2A ubiquitination (GO:0033522)4.11453135
22negative regulation of smooth muscle cell differentiation (GO:0051151)4.09671301
23oocyte maturation (GO:0001556)3.97082115
24prenylation (GO:0097354)3.96085412
25protein prenylation (GO:0018342)3.96085412
26regulation of axon guidance (GO:1902667)3.95731771
27DNA damage induced protein phosphorylation (GO:0006975)3.93365523
28notochord development (GO:0030903)3.91638747
29neuron fate determination (GO:0048664)3.90644029
30retinal ganglion cell axon guidance (GO:0031290)3.90271705
31synaptic vesicle endocytosis (GO:0048488)3.87623493
32regulation of meiotic cell cycle (GO:0051445)3.83337948
33negative regulation of meiosis (GO:0045835)3.80771446
34dopaminergic neuron differentiation (GO:0071542)3.80734885
35negative regulation of reproductive process (GO:2000242)3.79518812
36presynaptic membrane organization (GO:0097090)3.78857664
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77194496
38male meiosis (GO:0007140)3.75252185
39DNA methylation involved in gamete generation (GO:0043046)3.74304402
40positive regulation of amino acid transport (GO:0051957)3.73912368
41mesenchymal-epithelial cell signaling (GO:0060638)3.73697528
42regulation of exit from mitosis (GO:0007096)3.72078930
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69570848
44negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.68460091
45collagen fibril organization (GO:0030199)3.68433939
46neuron projection extension involved in neuron projection guidance (GO:1902284)3.65333561
47axon extension involved in axon guidance (GO:0048846)3.65333561
48primitive streak formation (GO:0090009)3.63359990
49regulation of sister chromatid cohesion (GO:0007063)3.60394300
50type B pancreatic cell development (GO:0003323)3.57471242
51regulation of acrosome reaction (GO:0060046)3.56850055
52vocalization behavior (GO:0071625)3.55705009
53motile cilium assembly (GO:0044458)3.49421527
54regulation of transforming growth factor beta2 production (GO:0032909)3.45991564
55meiotic cell cycle (GO:0051321)3.44074386
56otic vesicle formation (GO:0030916)3.42725575
57lateral sprouting from an epithelium (GO:0060601)3.42286515
58positive regulation of embryonic development (GO:0040019)3.41118486
59regulation of mitotic spindle organization (GO:0060236)3.39505247
60histone-serine phosphorylation (GO:0035404)3.38724080
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.35974659
62craniofacial suture morphogenesis (GO:0097094)3.35312625
63microtubule anchoring (GO:0034453)3.34303731
64microtubule severing (GO:0051013)3.33587704
65attachment of spindle microtubules to kinetochore (GO:0008608)3.31243828
66metaphase plate congression (GO:0051310)3.29561132
67striatum development (GO:0021756)3.28443010
68ovulation cycle (GO:0042698)3.27866548
69dorsal/ventral axis specification (GO:0009950)3.26969698
70mitotic sister chromatid segregation (GO:0000070)3.25615294
71positive regulation of male gonad development (GO:2000020)3.23841034
72regulation of spindle organization (GO:0090224)3.21298943
73protein localization to cilium (GO:0061512)3.20443566
74negative regulation of hormone metabolic process (GO:0032351)3.18575028
75negative regulation of hormone biosynthetic process (GO:0032353)3.18575028
76centriole replication (GO:0007099)3.17122821
77female gonad development (GO:0008585)3.16225028
78presynaptic membrane assembly (GO:0097105)3.15963991
79cytoskeleton-dependent cytokinesis (GO:0061640)3.13996521
80epithelial cilium movement (GO:0003351)3.13239832
81positive regulation of synapse assembly (GO:0051965)3.12813445
82glial cell migration (GO:0008347)3.11458233
83dopamine biosynthetic process (GO:0042416)3.10960928
84regulation of meiosis I (GO:0060631)3.10527933
85establishment of chromosome localization (GO:0051303)3.09153387
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08510241
87kidney mesenchyme development (GO:0072074)3.04444014
88metanephric mesenchyme development (GO:0072075)3.04366498
89base-excision repair, AP site formation (GO:0006285)3.04282083
90regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.03397272
91positive regulation of meiosis (GO:0045836)3.03116355
92kidney morphogenesis (GO:0060993)3.03107444
93bone trabecula formation (GO:0060346)3.02430439
94smoothened signaling pathway (GO:0007224)3.01118192
95axonemal dynein complex assembly (GO:0070286)3.00665351
96negative regulation of meiotic cell cycle (GO:0051447)3.00472570
97pyrimidine nucleobase catabolic process (GO:0006208)2.98144732
98cilium movement (GO:0003341)2.97255123
99regulation of phospholipid biosynthetic process (GO:0071071)2.95882228
100cilium assembly (GO:0042384)2.95760729
101mitotic cytokinesis (GO:0000281)2.94274505
102gene silencing by RNA (GO:0031047)2.93888573
103regulation of collateral sprouting (GO:0048670)2.93782285
104positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.93388466
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93270706
106regulation of early endosome to late endosome transport (GO:2000641)2.92669928
107regulation of keratinocyte proliferation (GO:0010837)2.92657728
108cilium organization (GO:0044782)2.92182527
109nonmotile primary cilium assembly (GO:0035058)2.92162956
110sequestering of extracellular ligand from receptor (GO:0035581)2.85912584
111neuron recognition (GO:0008038)2.84794696
112positive regulation of extracellular matrix organization (GO:1903055)2.84496550
113negative regulation of axon extension (GO:0030517)2.83333184
114sister chromatid segregation (GO:0000819)2.81741822
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79559473
116positive regulation of mitotic sister chromatid separation (GO:1901970)2.79559473
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79559473
118positive regulation of meiotic cell cycle (GO:0051446)2.79324840
119myoblast migration (GO:0051451)2.79323189
120citrulline biosynthetic process (GO:0019240)2.78498996
121cilium morphogenesis (GO:0060271)2.77648713
122regulation of retinoic acid receptor signaling pathway (GO:0048385)2.75610321
123negative chemotaxis (GO:0050919)2.75607086
124substrate-independent telencephalic tangential migration (GO:0021826)2.74500730
125substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.74500730
126somite development (GO:0061053)2.73753423
127dermatan sulfate biosynthetic process (GO:0030208)2.73741918
128regulation of male gonad development (GO:2000018)2.73715049
129axonal fasciculation (GO:0007413)2.73192395
130resolution of meiotic recombination intermediates (GO:0000712)2.73073710
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72460761
132positive regulation of sodium ion transmembrane transport (GO:1902307)2.72410220
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72264716
134short-term memory (GO:0007614)2.72010313
135cGMP metabolic process (GO:0046068)2.71900114
136establishment of spindle localization (GO:0051293)2.70923376
137somatic stem cell division (GO:0048103)2.70852199
138retinal cone cell development (GO:0046549)2.69698944
139establishment of nucleus localization (GO:0040023)2.69320007
140photoreceptor cell development (GO:0042461)2.68955702
141protein localization to kinetochore (GO:0034501)2.66923768
142negative regulation of catenin import into nucleus (GO:0035414)2.66827451
143dendritic spine morphogenesis (GO:0060997)2.66579354
144mitotic sister chromatid cohesion (GO:0007064)2.66131919
145mesenchymal cell proliferation (GO:0010463)2.64389685
146meiotic chromosome segregation (GO:0045132)2.64119338
147regulation of histone phosphorylation (GO:0033127)2.62637301
148positive regulation of chromosome segregation (GO:0051984)2.61952968
149synaptonemal complex assembly (GO:0007130)2.61906895
150multicellular organism reproduction (GO:0032504)2.61093309
151nucleus localization (GO:0051647)2.60759207
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60426960
153protein localization to chromosome (GO:0034502)2.60205269
154eye photoreceptor cell development (GO:0042462)2.59780137
155regulation of chemokine-mediated signaling pathway (GO:0070099)2.59621604
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59409231
157regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59378908
158muscle cell migration (GO:0014812)2.59005168
159radial glial cell differentiation (GO:0060019)2.58838348
160cell proliferation involved in metanephros development (GO:0072203)2.58816469
161regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56501790
162cGMP biosynthetic process (GO:0006182)2.55967764
163paraxial mesoderm development (GO:0048339)2.55771732
164embryonic cranial skeleton morphogenesis (GO:0048701)2.55202535
165protein heterotrimerization (GO:0070208)2.54730553
166secondary heart field specification (GO:0003139)2.54328735
167heart field specification (GO:0003128)2.54328735
168positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54171129
169glandular epithelial cell development (GO:0002068)2.53651128
170glycerophospholipid catabolic process (GO:0046475)2.53615421
171cerebellar Purkinje cell layer development (GO:0021680)2.52935241
172negative regulation of homotypic cell-cell adhesion (GO:0034111)2.52717331
173negative regulation of axon extension involved in axon guidance (GO:0048843)2.52384793
174protein localization to chromosome, centromeric region (GO:0071459)2.51487440
175dopamine transport (GO:0015872)2.51201280
176positive regulation of smoothened signaling pathway (GO:0045880)2.51151513
177positive regulation of dendritic spine morphogenesis (GO:0061003)2.50934311
178chromosome segregation (GO:0007059)2.50318619
179microtubule polymerization or depolymerization (GO:0031109)2.49713898
180positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48796642
181glomerulus development (GO:0032835)2.48223050
182positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.47708361
183smooth muscle tissue development (GO:0048745)2.47672858
184ventricular cardiac muscle cell development (GO:0055015)2.46857440
185regulation of voltage-gated calcium channel activity (GO:1901385)2.46814504
186ventricular system development (GO:0021591)2.46639487
187central nervous system projection neuron axonogenesis (GO:0021952)2.46085064
188oogenesis (GO:0048477)2.45891308
189spindle checkpoint (GO:0031577)2.45677883
190dermatan sulfate metabolic process (GO:0030205)2.45249569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.59261277
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.44440423
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.18428246
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87719854
5TAF15_26573619_Chip-Seq_HEK293_Human2.86183306
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.65857479
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.49269223
8EZH2_22144423_ChIP-Seq_EOC_Human2.40470523
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32917493
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26935661
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24154153
12GBX2_23144817_ChIP-Seq_PC3_Human2.21330974
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19227229
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15934394
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98721888
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96083556
17AR_21572438_ChIP-Seq_LNCaP_Human1.92176935
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86088266
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83421053
20* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83421053
21IGF1R_20145208_ChIP-Seq_DFB_Human1.81826258
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78280434
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75979080
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75714823
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.75025919
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72467810
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.67810499
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.67656268
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66448184
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60233910
31* CJUN_26792858_Chip-Seq_BT549_Human1.60059123
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.59292922
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.56871515
34AR_21909140_ChIP-Seq_LNCAP_Human1.56695682
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56111343
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55847615
37* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54584993
38* RNF2_27304074_Chip-Seq_NSC_Mouse1.50228669
39DROSHA_22980978_ChIP-Seq_HELA_Human1.49872694
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48594609
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48594540
42* EZH2_27304074_Chip-Seq_ESCs_Mouse1.48247248
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47697348
44* EP300_21415370_ChIP-Seq_HL-1_Mouse1.47240360
45TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46980166
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46942782
47REST_21632747_ChIP-Seq_MESCs_Mouse1.46007199
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45696855
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.45042135
50* STAT3_23295773_ChIP-Seq_U87_Human1.43112087
51* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42228254
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41811562
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40915883
54* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40642391
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40573089
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38276640
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36173526
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36038760
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35698629
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34555146
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34097054
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33143300
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32140707
64* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29079875
65ZNF274_21170338_ChIP-Seq_K562_Hela1.28932098
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.28564959
67TP53_16413492_ChIP-PET_HCT116_Human1.28452368
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27961305
69RUNX2_22187159_ChIP-Seq_PCA_Human1.27641129
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.27150543
71KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26374767
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25464809
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.25259260
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25145528
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23805564
76BRD4_25478319_ChIP-Seq_HGPS_Human1.23601456
77SOX9_26525672_Chip-Seq_HEART_Mouse1.23569199
78EWS_26573619_Chip-Seq_HEK293_Human1.22132551
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22122269
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21042769
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20903955
82P300_19829295_ChIP-Seq_ESCs_Human1.20741947
83JUN_21703547_ChIP-Seq_K562_Human1.20104124
84* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19271375
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18144478
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.17782936
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16904945
88RXR_22108803_ChIP-Seq_LS180_Human1.16113174
89* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16075767
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15954246
91* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15807943
92* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15731923
93AR_25329375_ChIP-Seq_VCAP_Human1.15558305
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14840655
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14840655
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14569154
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.13390159
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12855120
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.12143519
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12113999
101TCF4_23295773_ChIP-Seq_U87_Human1.11007178
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09452443
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09342540
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09070937
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08884681
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08813059
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08714779
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08714325
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07875008
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.07055559
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06641206
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06066195
113FUS_26573619_Chip-Seq_HEK293_Human1.05890268
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.05726142
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.05684783
116BCAT_22108803_ChIP-Seq_LS180_Human1.05573851
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05442127
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.04518276
119* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04299505
120* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02987240
121TCF4_22108803_ChIP-Seq_LS180_Human1.02578877
122ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01655123
123GF1B_26923725_Chip-Seq_HPCs_Mouse0.99286693
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99019635
125FLI1_21867929_ChIP-Seq_TH2_Mouse0.98376989
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98202452
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98182015
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97746999
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.97576313
130VDR_22108803_ChIP-Seq_LS180_Human0.96788681
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96724406
132TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96449996
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96327048
134* KDM2B_26808549_Chip-Seq_REH_Human0.93530012
135* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93291630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.07535407
2MP0003718_maternal_effect3.49945541
3MP0003880_abnormal_central_pattern3.42310532
4MP0005503_abnormal_tendon_morphology3.38355806
5MP0002102_abnormal_ear_morphology3.07545366
6MP0005275_abnormal_skin_tensile2.99153505
7MP0005257_abnormal_intraocular_pressure2.85469082
8MP0006292_abnormal_olfactory_placode2.51672323
9MP0003646_muscle_fatigue2.50196590
10MP0003705_abnormal_hypodermis_morpholog2.43833560
11MP0009384_cardiac_valve_regurgitation2.43080466
12MP0004145_abnormal_muscle_electrophysio2.41544319
13MP0009250_abnormal_appendicular_skeleto2.24926742
14MP0003136_yellow_coat_color2.22554345
15MP0010030_abnormal_orbit_morphology2.22179809
16MP0001299_abnormal_eye_distance/2.20829835
17MP0003890_abnormal_embryonic-extraembry2.18789823
18MP0006276_abnormal_autonomic_nervous2.17889791
19MP0005395_other_phenotype2.15185793
20MP0002234_abnormal_pharynx_morphology2.13166499
21MP0005451_abnormal_body_composition2.12686619
22MP0000569_abnormal_digit_pigmentation2.10131182
23MP0004859_abnormal_synaptic_plasticity2.09340638
24MP0000631_abnormal_neuroendocrine_gland2.03359080
25MP0008877_abnormal_DNA_methylation2.03179435
26MP0005187_abnormal_penis_morphology1.99842155
27MP0003279_aneurysm1.98721018
28MP0001346_abnormal_lacrimal_gland1.95341220
29MP0002837_dystrophic_cardiac_calcinosis1.92584401
30MP0003122_maternal_imprinting1.90379683
31MP0000537_abnormal_urethra_morphology1.90022196
32MP0002736_abnormal_nociception_after1.89247079
33MP0005508_abnormal_skeleton_morphology1.88309844
34* MP0003937_abnormal_limbs/digits/tail_de1.85424587
35MP0000372_irregular_coat_pigmentation1.77446061
36MP0001293_anophthalmia1.71931688
37MP0005171_absent_coat_pigmentation1.70980995
38* MP0003699_abnormal_female_reproductive1.67640213
39MP0000751_myopathy1.62478714
40MP0009745_abnormal_behavioral_response1.60760879
41MP0003635_abnormal_synaptic_transmissio1.60119018
42MP0003950_abnormal_plasma_membrane1.59033854
43MP0002822_catalepsy1.59031218
44MP0001968_abnormal_touch/_nociception1.57885328
45* MP0001119_abnormal_female_reproductive1.57245380
46MP0002932_abnormal_joint_morphology1.54125675
47MP0000428_abnormal_craniofacial_morphol1.50650779
48MP0003385_abnormal_body_wall1.49882626
49MP0001958_emphysema1.49094011
50MP0002063_abnormal_learning/memory/cond1.49049818
51MP0005423_abnormal_somatic_nervous1.48294582
52MP0008789_abnormal_olfactory_epithelium1.46743881
53MP0000534_abnormal_ureter_morphology1.45921684
54MP0005499_abnormal_olfactory_system1.45330872
55MP0005394_taste/olfaction_phenotype1.45330872
56MP0003091_abnormal_cell_migration1.43499781
57MP0004142_abnormal_muscle_tone1.43300228
58MP0002653_abnormal_ependyma_morphology1.41208525
59MP0001529_abnormal_vocalization1.40868606
60MP0001486_abnormal_startle_reflex1.37147128
61MP0001984_abnormal_olfaction1.34645953
62MP0004270_analgesia1.34546883
63MP0002064_seizures1.33815420
64* MP0002295_abnormal_pulmonary_circulatio1.33789782
65MP0000383_abnormal_hair_follicle1.33735859
66MP0000462_abnormal_digestive_system1.33406607
67MP0005551_abnormal_eye_electrophysiolog1.33234028
68MP0001177_atelectasis1.32458093
69* MP0003755_abnormal_palate_morphology1.32103525
70MP0003693_abnormal_embryo_hatching1.32031085
71MP0003315_abnormal_perineum_morphology1.31633354
72MP0002572_abnormal_emotion/affect_behav1.30274929
73* MP0002116_abnormal_craniofacial_bone1.27905218
74MP0000026_abnormal_inner_ear1.26234831
75MP0002177_abnormal_outer_ear1.25386085
76MP0002168_other_aberrant_phenotype1.25351183
77MP0002272_abnormal_nervous_system1.21884461
78MP0004133_heterotaxia1.20693725
79MP0001929_abnormal_gametogenesis1.17399671
80MP0003121_genomic_imprinting1.17253662
81MP0003119_abnormal_digestive_system1.15640314
82* MP0000653_abnormal_sex_gland1.14852655
83MP0001324_abnormal_eye_pigmentation1.14714762
84MP0002734_abnormal_mechanical_nocicepti1.14628799
85* MP0003942_abnormal_urinary_system1.14551359
86MP0003283_abnormal_digestive_organ1.14535882
87MP0002233_abnormal_nose_morphology1.13692582
88* MP0002109_abnormal_limb_morphology1.13645142
89MP0002751_abnormal_autonomic_nervous1.13532531
90MP0002557_abnormal_social/conspecific_i1.12289421
91MP0005253_abnormal_eye_physiology1.12093054
92MP0004185_abnormal_adipocyte_glucose1.11680338
93MP0010386_abnormal_urinary_bladder1.11573308
94MP0000566_synostosis1.11436852
95MP0002928_abnormal_bile_duct1.11173247
96MP0003787_abnormal_imprinting1.10879520
97MP0000049_abnormal_middle_ear1.10609195
98MP0002152_abnormal_brain_morphology1.09219852
99MP0005023_abnormal_wound_healing1.09205001
100MP0000955_abnormal_spinal_cord1.08966170
101MP0002938_white_spotting1.08214885
102MP0002638_abnormal_pupillary_reflex1.08056346
103MP0008932_abnormal_embryonic_tissue1.07582527
104MP0005391_vision/eye_phenotype1.07393073
105* MP0000163_abnormal_cartilage_morphology1.07267454
106MP0003123_paternal_imprinting1.06975793
107* MP0002249_abnormal_larynx_morphology1.06895036
108MP0002697_abnormal_eye_size1.06561434
109MP0005408_hypopigmentation1.06498602
110MP0001849_ear_inflammation1.06247638
111MP0001286_abnormal_eye_development1.06057147
112* MP0002115_abnormal_skeleton_extremities1.04990139
113MP0002210_abnormal_sex_determination1.04496669
114* MP0002085_abnormal_embryonic_tissue1.01032684
115MP0005646_abnormal_pituitary_gland1.00981523
116MP0003077_abnormal_cell_cycle0.99871851
117MP0003111_abnormal_nucleus_morphology0.98701280
118MP0009046_muscle_twitch0.98474283
119* MP0002282_abnormal_trachea_morphology0.96142023
120MP0000733_abnormal_muscle_development0.96098197
121* MP0003935_abnormal_craniofacial_develop0.96041130
122MP0002882_abnormal_neuron_morphology0.95970707
123MP0010094_abnormal_chromosome_stability0.95518641
124MP0009379_abnormal_foot_pigmentation0.95169949
125MP0005623_abnormal_meninges_morphology0.95097193
126MP0000767_abnormal_smooth_muscle0.94397661
127MP0002735_abnormal_chemical_nociception0.94273346
128MP0000639_abnormal_adrenal_gland0.93154032
129MP0001661_extended_life_span0.92408605
130MP0004272_abnormal_basement_membrane0.92185503
131MP0000762_abnormal_tongue_morphology0.91909020
132MP0005197_abnormal_uvea_morphology0.91505855
133MP0001879_abnormal_lymphatic_vessel0.91243657
134MP0002092_abnormal_eye_morphology0.90389596
135MP0002896_abnormal_bone_mineralization0.90223433
136MP0002114_abnormal_axial_skeleton0.89583330
137MP0000613_abnormal_salivary_gland0.89568128
138MP0003011_delayed_dark_adaptation0.88960793
139MP0002067_abnormal_sensory_capabilities0.88663480
140MP0003938_abnormal_ear_development0.88480321
141MP0004134_abnormal_chest_morphology0.88334895
142MP0001963_abnormal_hearing_physiology0.87547449
143MP0000350_abnormal_cell_proliferation0.87281250
144MP0005248_abnormal_Harderian_gland0.86830773
145* MP0000432_abnormal_head_morphology0.86546103
146MP0002752_abnormal_somatic_nervous0.85662296
147* MP0002084_abnormal_developmental_patter0.85432672
148* MP0002113_abnormal_skeleton_development0.84961363
149MP0003861_abnormal_nervous_system0.83945000
150* MP0002161_abnormal_fertility/fecundity0.83739566
151MP0000778_abnormal_nervous_system0.81742382
152MP0001915_intracranial_hemorrhage0.80258399
153MP0005195_abnormal_posterior_eye0.80099300
154MP0004742_abnormal_vestibular_system0.79967889
155MP0005386_behavior/neurological_phenoty0.79883154
156MP0004924_abnormal_behavior0.79883154
157MP0002184_abnormal_innervation0.79660386
158MP0004811_abnormal_neuron_physiology0.79625313
159MP0010678_abnormal_skin_adnexa0.78424400
160MP0001905_abnormal_dopamine_level0.78138365
161MP0000427_abnormal_hair_cycle0.77909625
162MP0004957_abnormal_blastocyst_morpholog0.76402233
163MP0003115_abnormal_respiratory_system0.75761988
164MP0009053_abnormal_anal_canal0.75564488
165MP0005076_abnormal_cell_differentiation0.75427523

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.89822686
2Shallow orbits (HP:0000586)4.69489445
3Premature rupture of membranes (HP:0001788)4.57790898
4Septo-optic dysplasia (HP:0100842)4.48667678
5Ankle contracture (HP:0006466)4.33333136
6Male infertility (HP:0003251)4.04482326
7Focal motor seizures (HP:0011153)3.97102246
8Aortic dissection (HP:0002647)3.86923198
9Vascular tortuosity (HP:0004948)3.79590972
10Coronal craniosynostosis (HP:0004440)3.62085612
11Cervical subluxation (HP:0003308)3.55674920
12Pancreatic fibrosis (HP:0100732)3.54034352
13Genu recurvatum (HP:0002816)3.48999361
14Peritonitis (HP:0002586)3.45024473
15True hermaphroditism (HP:0010459)3.35213971
16Arterial tortuosity (HP:0005116)3.27542402
17Abnormality of the labia minora (HP:0012880)3.25555479
18Abnormality of incisor morphology (HP:0011063)3.17292930
19Wrist flexion contracture (HP:0001239)3.16480482
20Aortic aneurysm (HP:0004942)3.14689251
21Abnormal ciliary motility (HP:0012262)3.11927489
22Cortical dysplasia (HP:0002539)3.09454871
23Short 4th metacarpal (HP:0010044)3.08176887
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08176887
25Broad metatarsal (HP:0001783)3.07696313
26Microglossia (HP:0000171)3.07363788
27Abnormality of dentin (HP:0010299)3.05999343
28Increased hepatocellular lipid droplets (HP:0006565)3.03843841
29Limb dystonia (HP:0002451)2.94821175
30Pancreatic cysts (HP:0001737)2.93602350
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.93073226
32Soft skin (HP:0000977)2.89213579
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.88547078
34Absent/shortened dynein arms (HP:0200106)2.88547078
35Flat capital femoral epiphysis (HP:0003370)2.86904881
36Abnormal respiratory motile cilium physiology (HP:0012261)2.85249737
37Spondylolisthesis (HP:0003302)2.81512685
38Absent septum pellucidum (HP:0001331)2.78420100
39Aplasia involving bones of the extremities (HP:0009825)2.74502441
40Aplasia involving bones of the upper limbs (HP:0009823)2.74502441
41Aplasia of the phalanges of the hand (HP:0009802)2.74502441
42Facial hemangioma (HP:0000329)2.67603165
43Supernumerary spleens (HP:0009799)2.65790860
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65190291
45Abnormality of the septum pellucidum (HP:0007375)2.64019906
46Rhinitis (HP:0012384)2.63888677
47Mitral valve prolapse (HP:0001634)2.63327774
48Midline defect of the nose (HP:0004122)2.62986625
49Abnormal respiratory motile cilium morphology (HP:0005938)2.62576055
50Abnormal respiratory epithelium morphology (HP:0012253)2.62576055
51Lipid accumulation in hepatocytes (HP:0006561)2.59612732
52Hyperextensible skin (HP:0000974)2.57647734
53Renal Fanconi syndrome (HP:0001994)2.56791243
54Genital tract atresia (HP:0001827)2.54448040
55Bladder diverticulum (HP:0000015)2.52901262
56Vaginal atresia (HP:0000148)2.52361437
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51283774
58Cystic liver disease (HP:0006706)2.50622893
59Oligodactyly (hands) (HP:0001180)2.50245579
60Spinal cord compression (HP:0002176)2.49393489
61Camptodactyly of toe (HP:0001836)2.46052063
62Hypoplastic pelvis (HP:0008839)2.44630530
63Abnormal lung lobation (HP:0002101)2.43224366
64Nephronophthisis (HP:0000090)2.40783105
65Tubulointerstitial nephritis (HP:0001970)2.40595765
66Papillary thyroid carcinoma (HP:0002895)2.39039769
67Optic nerve hypoplasia (HP:0000609)2.38543199
68Dilatation of the ascending aorta (HP:0005111)2.37736958
69Follicular hyperkeratosis (HP:0007502)2.34768056
70Abnormality of the 4th metacarpal (HP:0010012)2.33437590
71Type II lissencephaly (HP:0007260)2.32988370
72Split foot (HP:0001839)2.32767481
73Abnormality of abdominal situs (HP:0011620)2.32091575
74Abdominal situs inversus (HP:0003363)2.32091575
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.31762665
76Infantile muscular hypotonia (HP:0008947)2.29805883
77Asplenia (HP:0001746)2.28833782
78Molar tooth sign on MRI (HP:0002419)2.27066164
79Abnormality of midbrain morphology (HP:0002418)2.27066164
80Congenital, generalized hypertrichosis (HP:0004540)2.26309841
81Bifid tongue (HP:0010297)2.25459599
82Tubulointerstitial abnormality (HP:0001969)2.23902587
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.22528999
84Postaxial foot polydactyly (HP:0001830)2.20966305
85Adrenal hypoplasia (HP:0000835)2.20554269
86Delayed gross motor development (HP:0002194)2.19476117
87Arachnodactyly (HP:0001166)2.18977891
88Bowel diverticulosis (HP:0005222)2.17988524
89Sleep apnea (HP:0010535)2.17472432
90Stomach cancer (HP:0012126)2.15887152
91Abnormality of the renal medulla (HP:0100957)2.14754245
92Neonatal short-limb short stature (HP:0008921)2.13834560
93Knee flexion contracture (HP:0006380)2.13569241
94Abnormality of the distal phalanx of the thumb (HP:0009617)2.11875907
95Hepatoblastoma (HP:0002884)2.11856452
96Focal seizures (HP:0007359)2.10482039
97Hyperglycinuria (HP:0003108)2.09026262
98Gastrointestinal atresia (HP:0002589)2.08197657
99Median cleft lip (HP:0000161)2.07808609
100Esophageal atresia (HP:0002032)2.07569360
101Abnormality of the middle phalanges of the toes (HP:0010183)2.05670171
102Hip dysplasia (HP:0001385)2.03426113
103Cutaneous finger syndactyly (HP:0010554)2.03358993
104Broad long bones (HP:0005622)2.03349827
105Bell-shaped thorax (HP:0001591)2.03080035
106Enlarged penis (HP:0000040)2.01977104
107Hypoventilation (HP:0002791)2.00658307
108Blue sclerae (HP:0000592)2.00543089
109Infertility (HP:0000789)1.99022976
110Shawl scrotum (HP:0000049)1.98758195
111Postaxial hand polydactyly (HP:0001162)1.97389711
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95093300
113Gait imbalance (HP:0002141)1.93996422
114Biconcave vertebral bodies (HP:0004586)1.93737667
115Anophthalmia (HP:0000528)1.92540669
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.92122101
117Preaxial hand polydactyly (HP:0001177)1.91555456
118Aqueductal stenosis (HP:0002410)1.91343828
119Atelectasis (HP:0100750)1.91275673
120Striae distensae (HP:0001065)1.90908824
121Buphthalmos (HP:0000557)1.90861906
122Occipital encephalocele (HP:0002085)1.90179171
123Wormian bones (HP:0002645)1.89306409
124Wide anterior fontanel (HP:0000260)1.89004876
125Hypoplasia of the odontoid process (HP:0003311)1.88027856
126Alacrima (HP:0000522)1.87759633
127Narrow forehead (HP:0000341)1.87637638
128Megalencephaly (HP:0001355)1.87200502
129Congenital hepatic fibrosis (HP:0002612)1.86403146
130Elbow flexion contracture (HP:0002987)1.86182891
131Oligodactyly (HP:0012165)1.83442622
132Medial flaring of the eyebrow (HP:0010747)1.83036154
133Mild short stature (HP:0003502)1.82981326
134Overgrowth (HP:0001548)1.82831314
135Premature ovarian failure (HP:0008209)1.82787643
136Trigonocephaly (HP:0000243)1.82553015
137Slender build (HP:0001533)1.82519312
138Fibular aplasia (HP:0002990)1.82415948
139Abnormality of the anterior chamber (HP:0000593)1.82363158
140Tubulointerstitial fibrosis (HP:0005576)1.82065482
141Broad ribs (HP:0000885)1.81319977
142Atrophic scars (HP:0001075)1.81197356
143Broad phalanx (HP:0006009)1.80997272
144Deviation of the hallux (HP:0010051)1.80553102
145Chronic hepatic failure (HP:0100626)1.80124076
146Secondary amenorrhea (HP:0000869)1.80106460
147Long toe (HP:0010511)1.79500217
148Patellar aplasia (HP:0006443)1.79420704
149Abnormality of the parietal bone (HP:0002696)1.77167350
150Cutaneous syndactyly (HP:0012725)1.76069853
151Short nail (HP:0001799)1.75992158
152Exertional dyspnea (HP:0002875)1.75853415
153Thickened helices (HP:0000391)1.75300786
154Hyperventilation (HP:0002883)1.75140408
155Joint laxity (HP:0001388)1.74969269
156Intestinal atresia (HP:0011100)1.74665285
157Abnormal delivery (HP:0001787)1.73477284
158Congenital primary aphakia (HP:0007707)1.73032267
159Embryonal renal neoplasm (HP:0011794)1.72759684
160Anterior segment dysgenesis (HP:0007700)1.72333003
161Anencephaly (HP:0002323)1.72227174
162Hallux valgus (HP:0001822)1.72170107
163Myokymia (HP:0002411)1.71328502
164Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70244190
165Abnormality of the odontoid process (HP:0003310)1.69541028
166Breast hypoplasia (HP:0003187)1.69470962
167Tibial bowing (HP:0002982)1.68609640
168Cerebral aneurysm (HP:0004944)1.68423312
169Abnormality of the phalanges of the hallux (HP:0010057)1.67668900
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.67549785
171Respiratory difficulties (HP:0002880)1.67373564
172Congenital glaucoma (HP:0001087)1.67143785
173Spinal cord lesions (HP:0100561)1.66954285
174Syringomyelia (HP:0003396)1.66954285
175Intellectual disability, moderate (HP:0002342)1.66486462
176Abnormality of the acetabulum (HP:0003170)1.65839628
177Partial duplication of the phalanx of hand (HP:0009999)1.65629691
178Broad distal phalanx of finger (HP:0009836)1.65369563
179Abnormality of the incisor (HP:0000676)1.65313597
180Hyperphosphaturia (HP:0003109)1.65280153
181Obstructive sleep apnea (HP:0002870)1.65190550
182Anosmia (HP:0000458)1.65181980
183Flexion contracture of toe (HP:0005830)1.64989086
184Joint contractures involving the joints of the feet (HP:0100492)1.64989086
185Broad hallux (HP:0010055)1.64975641
186Aneurysm (HP:0002617)1.64572254
187Sparse lateral eyebrow (HP:0005338)1.64263252
188Abnormality of cochlea (HP:0000375)1.64091982
189Aplasia/Hypoplasia of the breasts (HP:0010311)1.63691577
190Aplasia/Hypoplasia of the patella (HP:0006498)1.63687227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.60389663
2LATS14.11763892
3TNIK3.86769869
4DDR23.71477527
5KSR23.68014710
6PNCK3.50243238
7MAP3K63.16385094
8CASK3.06323605
9MAP3K92.95880203
10ERBB42.64294115
11EEF2K2.46964279
12MOS2.33150015
13KSR12.23769613
14STK242.21775567
15PAK62.14284402
16STK38L2.12039552
17TTK2.10839495
18BRAF2.08123287
19TAOK32.03827013
20WNK32.02163274
21MAPK152.00241842
22BMPR1B1.99128637
23IRAK21.95864854
24PRKD31.95643730
25TAOK11.80948096
26MAP3K71.79176426
27CDK81.76133195
28RAF11.71611379
29ACVR1B1.66531493
30PINK11.65382206
31MAP3K121.64759207
32STK31.62105048
33BRSK21.61167204
34NTRK11.60327960
35IRAK11.59638580
36WEE11.58882868
37TGFBR11.57162617
38MAP3K41.55885066
39PLK41.54702621
40MELK1.51249493
41ARAF1.45933717
42PLK21.45629038
43TLK11.44108818
44PKN11.43987229
45MUSK1.43025565
46PDGFRA1.40914049
47RET1.40272241
48MAPKAPK31.31837942
49MAPK131.29416442
50CHEK21.20744662
51TSSK61.20432978
52BMPR21.20397902
53DMPK1.20329429
54TRIB31.19973693
55MAP3K131.15911105
56BRD41.10678849
57MAPKAPK51.07853619
58PRKCG1.07305259
59NTRK31.05865072
60EPHA31.04971668
61MAP2K71.02063166
62EPHB21.00480965
63CDC70.99616761
64MAP2K40.98408246
65MKNK20.97710967
66NEK20.94527646
67MAP3K20.94375413
68SIK10.93633533
69STK390.93529421
70BUB10.92188612
71STK380.91287306
72STK100.90977574
73PASK0.89097912
74MKNK10.87960331
75PLK10.83441876
76VRK10.83143065
77OXSR10.82812283
78PAK30.82583408
79BRSK10.81056040
80DYRK20.80648896
81PRKD20.80478295
82TRPM70.80305911
83ABL20.80231310
84SRPK10.78990140
85MAP3K80.74506667
86YES10.74484052
87NEK60.71060517
88CHUK0.69713291
89CDK90.65682789
90MAP2K10.65257423
91ADRBK20.64037264
92PLK30.63250319
93UHMK10.62000476
94NTRK20.60013507
95TYRO30.59221809
96MINK10.58827633
97GRK10.57664724
98GRK50.57369706
99ROCK10.56691803
100AURKA0.55297291
101FGFR20.54771899
102WNK40.53089223
103MARK20.52556054
104EPHA40.51497133
105TTN0.51109980
106VRK20.51056304
107CSNK1G10.50370836
108PTK2B0.50350311
109PTK20.49999221
110CSNK1G20.49766205
111PRKCE0.48942481
112CDK50.46911400
113FGFR10.45791667
114LIMK10.45654027
115PRKACB0.44648821
116PDGFRB0.43965907
117MAP4K20.38625245
118CSNK1A1L0.38191619
119CAMK2B0.36597710
120MAPK110.36175971
121PRKAA10.36075586
122MARK10.35404586
123ROCK20.34547473
124PRKCZ0.34463484
125DYRK1A0.34367644
126PRKG10.33489920
127CDK180.33334571
128FER0.32665293
129MAP3K10.32209044
130CDK11A0.31447102
131ERBB30.31170869
132EIF2AK20.30428094
133CAMK10.29544846
134CDK150.29479718
135MTOR0.29185340
136CAMK2A0.28921734
137ADRBK10.28659617
138CSNK1D0.26657306
139FRK0.26636985
140CSNK1E0.26394487
141CDK140.25557238
142AURKB0.25493889
143NEK90.24813304
144SGK10.24443386
145PIK3CA0.24154685
146CDK120.24030099
147CSNK1G30.23155730
148CDC42BPA0.22813687
149MAP3K50.22147587
150STK110.21596452
151NUAK10.21516088
152PRKCH0.21315552
153RIPK10.21114945

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76449848
2Ovarian steroidogenesis_Homo sapiens_hsa049132.71217436
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43469924
4Protein export_Homo sapiens_hsa030602.38745824
5Cell cycle_Homo sapiens_hsa041102.30428167
6Phototransduction_Homo sapiens_hsa047442.09582002
7GnRH signaling pathway_Homo sapiens_hsa049122.07253181
8Oocyte meiosis_Homo sapiens_hsa041142.06728394
9Pancreatic cancer_Homo sapiens_hsa052121.99686040
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.97792045
11TGF-beta signaling pathway_Homo sapiens_hsa043501.88790908
12Dorso-ventral axis formation_Homo sapiens_hsa043201.79625510
13MicroRNAs in cancer_Homo sapiens_hsa052061.78615655
14Hedgehog signaling pathway_Homo sapiens_hsa043401.76957204
15Glioma_Homo sapiens_hsa052141.71407298
16Colorectal cancer_Homo sapiens_hsa052101.68976296
17Basal cell carcinoma_Homo sapiens_hsa052171.68673178
18Cocaine addiction_Homo sapiens_hsa050301.62112611
19Hippo signaling pathway_Homo sapiens_hsa043901.61335293
20mTOR signaling pathway_Homo sapiens_hsa041501.59149293
21Melanoma_Homo sapiens_hsa052181.57405449
22Amphetamine addiction_Homo sapiens_hsa050311.55758519
23VEGF signaling pathway_Homo sapiens_hsa043701.50147852
24Choline metabolism in cancer_Homo sapiens_hsa052311.47888117
25Adherens junction_Homo sapiens_hsa045201.47813075
26Basal transcription factors_Homo sapiens_hsa030221.47449164
27ECM-receptor interaction_Homo sapiens_hsa045121.43699230
28Propanoate metabolism_Homo sapiens_hsa006401.41888366
29Renal cell carcinoma_Homo sapiens_hsa052111.40396289
30Morphine addiction_Homo sapiens_hsa050321.39737492
31Bladder cancer_Homo sapiens_hsa052191.39312933
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38851273
33Regulation of autophagy_Homo sapiens_hsa041401.38421603
34Long-term depression_Homo sapiens_hsa047301.37855736
35RNA degradation_Homo sapiens_hsa030181.37032876
36Prolactin signaling pathway_Homo sapiens_hsa049171.36490695
37Endometrial cancer_Homo sapiens_hsa052131.34234021
38Base excision repair_Homo sapiens_hsa034101.33396294
39Oxidative phosphorylation_Homo sapiens_hsa001901.32139229
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31690450
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30492019
42Chronic myeloid leukemia_Homo sapiens_hsa052201.29090544
43Cardiac muscle contraction_Homo sapiens_hsa042601.27259522
44Focal adhesion_Homo sapiens_hsa045101.26865604
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25260463
46GABAergic synapse_Homo sapiens_hsa047271.25162529
47Wnt signaling pathway_Homo sapiens_hsa043101.23562576
48Circadian rhythm_Homo sapiens_hsa047101.22483601
49Estrogen signaling pathway_Homo sapiens_hsa049151.19694200
50Insulin secretion_Homo sapiens_hsa049111.16944628
51Melanogenesis_Homo sapiens_hsa049161.15524573
52p53 signaling pathway_Homo sapiens_hsa041151.14247108
53Butanoate metabolism_Homo sapiens_hsa006501.13104507
54ErbB signaling pathway_Homo sapiens_hsa040121.12914901
55Long-term potentiation_Homo sapiens_hsa047201.11414295
56Glycerolipid metabolism_Homo sapiens_hsa005611.10766484
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10286100
58Ras signaling pathway_Homo sapiens_hsa040141.09699530
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08936635
60Proteoglycans in cancer_Homo sapiens_hsa052051.08316694
61Non-small cell lung cancer_Homo sapiens_hsa052231.07856160
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07659167
63Glutamatergic synapse_Homo sapiens_hsa047241.07584288
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.06464080
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.05989742
66Taste transduction_Homo sapiens_hsa047421.05928024
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05399190
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03931621
69Gap junction_Homo sapiens_hsa045401.03531621
70Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03132962
71Amoebiasis_Homo sapiens_hsa051461.02877509
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02614122
73Axon guidance_Homo sapiens_hsa043600.99169390
74Parkinsons disease_Homo sapiens_hsa050120.99101105
75Thyroid cancer_Homo sapiens_hsa052160.98452058
76Vitamin B6 metabolism_Homo sapiens_hsa007500.96595239
77Prostate cancer_Homo sapiens_hsa052150.93640737
78Oxytocin signaling pathway_Homo sapiens_hsa049210.93511671
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92887728
80Synaptic vesicle cycle_Homo sapiens_hsa047210.90310851
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88918464
82beta-Alanine metabolism_Homo sapiens_hsa004100.88758405
83FoxO signaling pathway_Homo sapiens_hsa040680.88711251
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88267663
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86199862
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86001943
87Rap1 signaling pathway_Homo sapiens_hsa040150.85376574
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85366712
89Huntingtons disease_Homo sapiens_hsa050160.84997922
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82179198
91MAPK signaling pathway_Homo sapiens_hsa040100.81708820
92Pathways in cancer_Homo sapiens_hsa052000.81664639
93Calcium signaling pathway_Homo sapiens_hsa040200.80678958
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80089181
95Cholinergic synapse_Homo sapiens_hsa047250.79794391
96Linoleic acid metabolism_Homo sapiens_hsa005910.79426058
97Serotonergic synapse_Homo sapiens_hsa047260.77762711
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.77731263
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77460449
100Dopaminergic synapse_Homo sapiens_hsa047280.77316321
101Small cell lung cancer_Homo sapiens_hsa052220.76885493
102Nitrogen metabolism_Homo sapiens_hsa009100.76581022
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75720597
104Ether lipid metabolism_Homo sapiens_hsa005650.72236432
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.71442170
106Nicotine addiction_Homo sapiens_hsa050330.71363515
107Gastric acid secretion_Homo sapiens_hsa049710.71019985
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70669682
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.70297733
110Shigellosis_Homo sapiens_hsa051310.68928761
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68230585
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.67858071
113Collecting duct acid secretion_Homo sapiens_hsa049660.67058657
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66760075
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66437496
116Steroid biosynthesis_Homo sapiens_hsa001000.65955049
117cAMP signaling pathway_Homo sapiens_hsa040240.65400746
118Hepatitis B_Homo sapiens_hsa051610.65149879
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65000294
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64540369
121HTLV-I infection_Homo sapiens_hsa051660.64499682
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64293370
123Dilated cardiomyopathy_Homo sapiens_hsa054140.63465700
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63157310
125RNA transport_Homo sapiens_hsa030130.62925264
126Olfactory transduction_Homo sapiens_hsa047400.62031772
127Bile secretion_Homo sapiens_hsa049760.61666119
128Circadian entrainment_Homo sapiens_hsa047130.61259473
129Salivary secretion_Homo sapiens_hsa049700.60822891
130Homologous recombination_Homo sapiens_hsa034400.60001646
131Protein digestion and absorption_Homo sapiens_hsa049740.59933386
132Tight junction_Homo sapiens_hsa045300.59796022
133mRNA surveillance pathway_Homo sapiens_hsa030150.59640481
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59061169
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57822426
136Type II diabetes mellitus_Homo sapiens_hsa049300.57736782
137Fanconi anemia pathway_Homo sapiens_hsa034600.57532031
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55558033
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54740307
140Alzheimers disease_Homo sapiens_hsa050100.54068133
141Folate biosynthesis_Homo sapiens_hsa007900.53802686
142Inositol phosphate metabolism_Homo sapiens_hsa005620.51772429
143Thyroid hormone synthesis_Homo sapiens_hsa049180.50335336
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46949097
145Vitamin digestion and absorption_Homo sapiens_hsa049770.44031303
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.43346901
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41581340
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41097227
149RNA polymerase_Homo sapiens_hsa030200.39783968
150Pancreatic secretion_Homo sapiens_hsa049720.37477385
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36433116

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