RSPO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal-epithelial cell signaling (GO:0060638)8.26246615
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)8.18027356
3lateral sprouting from an epithelium (GO:0060601)8.14151449
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.75433971
5regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.54913475
6craniofacial suture morphogenesis (GO:0097094)6.41273834
7pyrimidine nucleobase catabolic process (GO:0006208)6.02761305
8bone trabecula formation (GO:0060346)5.93919297
9behavioral response to nicotine (GO:0035095)5.87158982
10cell proliferation involved in metanephros development (GO:0072203)5.60886576
11cell proliferation involved in kidney development (GO:0072111)5.46517675
12sequestering of extracellular ligand from receptor (GO:0035581)5.42779961
13mesenchymal cell proliferation (GO:0010463)5.33666413
14branching involved in prostate gland morphogenesis (GO:0060442)5.09980790
15planar cell polarity pathway involved in neural tube closure (GO:0090179)5.09020771
16regulation of non-canonical Wnt signaling pathway (GO:2000050)4.95491026
17radial glial cell differentiation (GO:0060019)4.86267985
18keratinocyte proliferation (GO:0043616)4.84351085
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.81511164
20retinal ganglion cell axon guidance (GO:0031290)4.74863898
21cranial suture morphogenesis (GO:0060363)4.74404150
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.71596710
23branching involved in salivary gland morphogenesis (GO:0060445)4.62582246
24nucleobase catabolic process (GO:0046113)4.57589531
25limb bud formation (GO:0060174)4.33000088
26otic vesicle formation (GO:0030916)4.28993399
27positive regulation of gastrulation (GO:2000543)4.25256980
28negative regulation of axon guidance (GO:1902668)4.12120501
29negative regulation of osteoblast proliferation (GO:0033689)4.05271036
30intraciliary transport (GO:0042073)4.04105141
31mesonephros development (GO:0001823)4.02569724
32artery smooth muscle contraction (GO:0014824)4.02128814
33somite development (GO:0061053)4.01871749
34regulation of keratinocyte proliferation (GO:0010837)4.01413452
35prostate gland epithelium morphogenesis (GO:0060740)3.97321832
36organ induction (GO:0001759)3.97185197
37epithelial cilium movement (GO:0003351)3.94035011
38proximal/distal pattern formation (GO:0009954)3.92389242
39axonal fasciculation (GO:0007413)3.92034718
40convergent extension (GO:0060026)3.90635258
41dermatan sulfate biosynthetic process (GO:0030208)3.86075197
42regulation of collateral sprouting (GO:0048670)3.80977001
43tonic smooth muscle contraction (GO:0014820)3.80599416
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77674393
45mesenchymal cell differentiation (GO:0048762)3.76379839
46cartilage morphogenesis (GO:0060536)3.73995770
47branch elongation of an epithelium (GO:0060602)3.72948625
48glial cell migration (GO:0008347)3.72511919
49negative regulation of catenin import into nucleus (GO:0035414)3.67974998
50hindlimb morphogenesis (GO:0035137)3.63237014
51axis elongation (GO:0003401)3.60658053
52hair follicle morphogenesis (GO:0031069)3.59673158
53cerebellar Purkinje cell differentiation (GO:0021702)3.58807841
54renal system development (GO:0072001)3.53897215
55olfactory bulb development (GO:0021772)3.52450052
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52134363
57morphogenesis of an epithelial fold (GO:0060571)3.51929556
58chondrocyte proliferation (GO:0035988)3.48931140
59establishment of mitochondrion localization (GO:0051654)3.47785783
60digestive tract morphogenesis (GO:0048546)3.45480554
61Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.43322957
62dermatan sulfate metabolic process (GO:0030205)3.42807874
63mitochondrion transport along microtubule (GO:0047497)3.42129054
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.42129054
65neuronal ion channel clustering (GO:0045161)3.38991456
66neuron recognition (GO:0008038)3.36812778
67sarcoplasmic reticulum calcium ion transport (GO:0070296)3.36272043
68short-term memory (GO:0007614)3.36255418
69embryonic forelimb morphogenesis (GO:0035115)3.35239407
70regulation of establishment of planar polarity (GO:0090175)3.33782232
71negative regulation of chondrocyte differentiation (GO:0032331)3.33320590
72regulation of morphogenesis of a branching structure (GO:0060688)3.31609857
73actin-myosin filament sliding (GO:0033275)3.31458712
74muscle filament sliding (GO:0030049)3.31458712
75chondrocyte development (GO:0002063)3.29637254
76protein localization to cell surface (GO:0034394)3.29370678
77negative regulation of axon extension involved in axon guidance (GO:0048843)3.26664171
78cell differentiation involved in kidney development (GO:0061005)3.26437067
79cilium movement (GO:0003341)3.25569903
80cellular response to cholesterol (GO:0071397)3.23252019
81dendritic spine morphogenesis (GO:0060997)3.22764794
82regulation of skeletal muscle contraction (GO:0014819)3.22698480
83organ formation (GO:0048645)3.20794388
84central nervous system projection neuron axonogenesis (GO:0021952)3.19553490
85embryonic hindlimb morphogenesis (GO:0035116)3.19362554
86spinal cord association neuron differentiation (GO:0021527)3.19229558
87negative regulation of fibroblast apoptotic process (GO:2000270)3.18621160
88negative regulation of JUN kinase activity (GO:0043508)3.18030602
89cardiac myofibril assembly (GO:0055003)3.17765671
90embryonic cranial skeleton morphogenesis (GO:0048701)3.17475368
91cellular response to vitamin D (GO:0071305)3.16722445
92trabecula formation (GO:0060343)3.14951597
93presynaptic membrane organization (GO:0097090)3.14542397
94lung-associated mesenchyme development (GO:0060484)3.14454521
95extracellular negative regulation of signal transduction (GO:1900116)3.14009175
96extracellular regulation of signal transduction (GO:1900115)3.14009175
97negative regulation of stem cell proliferation (GO:2000647)3.13789367
98regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13023264
99positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.12488795
100negative regulation of smoothened signaling pathway (GO:0045879)3.10628364
101positive regulation of mitochondrial fission (GO:0090141)3.09653262
102regulation of axon guidance (GO:1902667)3.09461995
103cornea development in camera-type eye (GO:0061303)3.07919304
104regulation of pigment cell differentiation (GO:0050932)3.05555220
105outer ear morphogenesis (GO:0042473)3.05513165
106embryonic skeletal joint morphogenesis (GO:0060272)3.05481939
107bone morphogenesis (GO:0060349)3.04268157
108embryonic appendage morphogenesis (GO:0035113)3.04128618
109embryonic limb morphogenesis (GO:0030326)3.04128618
110axon extension (GO:0048675)3.01328514
111dorsal/ventral axis specification (GO:0009950)3.00153340
112organ growth (GO:0035265)2.98477747
113NLS-bearing protein import into nucleus (GO:0006607)2.98105186
114regulation of chondrocyte differentiation (GO:0032330)2.97904689
115substrate-independent telencephalic tangential migration (GO:0021826)2.97502096
116substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97502096
117head development (GO:0060322)2.97214091
118heart morphogenesis (GO:0003007)2.96761905
119collagen fibril organization (GO:0030199)2.96307106
120negative chemotaxis (GO:0050919)2.95478812
121branching involved in ureteric bud morphogenesis (GO:0001658)2.95309082
122regulation of smoothened signaling pathway (GO:0008589)2.94501674
123myofibril assembly (GO:0030239)2.94263256
124negative regulation of embryonic development (GO:0045992)2.94058588
125endoderm formation (GO:0001706)2.92523378
126glomerulus development (GO:0032835)2.92249490
127uterus development (GO:0060065)2.92163106
128forelimb morphogenesis (GO:0035136)2.92068618
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.91749013
130embryonic digestive tract morphogenesis (GO:0048557)2.91433706
131non-canonical Wnt signaling pathway (GO:0035567)2.90700125
132retinal cone cell development (GO:0046549)2.89844362
133cell proliferation in forebrain (GO:0021846)2.89189832
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.88750307
135positive regulation of sodium ion transmembrane transport (GO:1902307)2.88608204
136actin-mediated cell contraction (GO:0070252)2.87728025
137appendage morphogenesis (GO:0035107)2.87002086
138limb morphogenesis (GO:0035108)2.87002086
139synaptic transmission, cholinergic (GO:0007271)2.85735161
140embryonic skeletal system development (GO:0048706)2.85103195
141response to follicle-stimulating hormone (GO:0032354)2.84812230
142regulation of organ formation (GO:0003156)2.84246038
143axoneme assembly (GO:0035082)2.84054469
144axon extension involved in axon guidance (GO:0048846)2.83237844
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.83237844
146cilium assembly (GO:0042384)2.82611949
147regulation of sarcomere organization (GO:0060297)2.82202756
148cell migration in hindbrain (GO:0021535)2.80528354
149regulation of systemic arterial blood pressure by hormone (GO:0001990)2.80474099
150regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.80474099
151endocrine process (GO:0050886)2.80474099
152protein polyglutamylation (GO:0018095)2.79405959
153regulation of cartilage development (GO:0061035)2.79357149
154cardiac chamber formation (GO:0003207)2.78750746
155vascular smooth muscle contraction (GO:0014829)2.78501150
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77825680
157neuromuscular synaptic transmission (GO:0007274)2.76218559
158cilium organization (GO:0044782)2.75220041
159protein localization to synapse (GO:0035418)2.74620309
160positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74439494
161transmission of nerve impulse (GO:0019226)2.72722823
162locomotory exploration behavior (GO:0035641)2.72413435
163axonemal dynein complex assembly (GO:0070286)2.72071863
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70996312
165dentate gyrus development (GO:0021542)2.69129097
166central nervous system neuron axonogenesis (GO:0021955)2.68609955
167regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68227946
168negative regulation of axonogenesis (GO:0050771)2.66510325
169paraxial mesoderm development (GO:0048339)2.66448756
170forebrain neuron differentiation (GO:0021879)2.66386111
171dendrite development (GO:0016358)2.64379628
172cellular component assembly involved in morphogenesis (GO:0010927)2.62072231
173cilium morphogenesis (GO:0060271)2.60992258
174protein localization to cilium (GO:0061512)2.60567864
175microtubule bundle formation (GO:0001578)2.59378948
176regulation of cilium movement (GO:0003352)2.55577146
177striatum development (GO:0021756)2.55240813
178negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53516813
179synaptic vesicle endocytosis (GO:0048488)2.53298658
180negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53116024
181adult heart development (GO:0007512)2.52935359
182spinal cord development (GO:0021510)2.52407993
183motile cilium assembly (GO:0044458)2.51785023
184postsynaptic membrane organization (GO:0001941)2.51235472
185left/right pattern formation (GO:0060972)2.49509603
186nonmotile primary cilium assembly (GO:0035058)2.49151645
187neural tube formation (GO:0001841)2.48189657
188muscle fiber development (GO:0048747)2.46956780
189neuron migration (GO:0001764)2.46877617
190adult walking behavior (GO:0007628)2.45713671
191regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.45310596
192regulation of axon extension involved in axon guidance (GO:0048841)2.44500396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.02255357
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.94763269
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.56170668
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.27475340
5EZH2_22144423_ChIP-Seq_EOC_Human3.25009261
6GBX2_23144817_ChIP-Seq_PC3_Human2.93593466
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78975485
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.75366093
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73558158
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71148047
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71148047
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65857938
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65194030
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57402698
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55214222
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51747264
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43669813
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42303620
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.32012708
20AR_21572438_ChIP-Seq_LNCaP_Human2.27429506
21IGF1R_20145208_ChIP-Seq_DFB_Human2.26811253
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.25487474
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.13524786
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.10852094
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10736246
26RNF2_27304074_Chip-Seq_NSC_Mouse2.03234693
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02787998
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.94907739
29REST_21632747_ChIP-Seq_MESCs_Mouse1.82186113
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.78661191
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76947291
32P300_19829295_ChIP-Seq_ESCs_Human1.72782461
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.72413349
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70248763
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67598488
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.66800309
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66621671
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65679916
39TP53_18474530_ChIP-ChIP_U2OS_Human1.62861650
40SMAD4_21799915_ChIP-Seq_A2780_Human1.62712777
41VDR_22108803_ChIP-Seq_LS180_Human1.61910415
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61850837
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61266760
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59673796
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58778045
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57230289
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56620356
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55790786
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.49929100
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49777335
51IRF1_19129219_ChIP-ChIP_H3396_Human1.49146877
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48796355
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.48311732
54* TP53_20018659_ChIP-ChIP_R1E_Mouse1.46434200
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46429260
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.45989276
57ZNF274_21170338_ChIP-Seq_K562_Hela1.45827418
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45575925
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44505592
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.43728563
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.43421549
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42447372
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39697259
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38432358
65* FUS_26573619_Chip-Seq_HEK293_Human1.38360977
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33349082
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.33177206
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32650780
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32411783
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32399817
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32399817
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.32277128
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32164487
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29731575
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28408798
76AHR_22903824_ChIP-Seq_MCF-7_Human1.28153630
77TP53_16413492_ChIP-PET_HCT116_Human1.27943082
78DROSHA_22980978_ChIP-Seq_HELA_Human1.27201220
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25745180
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.24026080
81* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23813816
82RXR_22108803_ChIP-Seq_LS180_Human1.23066541
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22683466
84BCAT_22108803_ChIP-Seq_LS180_Human1.22632332
85* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22589432
86AR_25329375_ChIP-Seq_VCAP_Human1.21343935
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20659390
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.20261153
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19005292
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19005292
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18597745
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18591775
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18591775
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18591775
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14922863
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14685015
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13481881
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12580284
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.11428504
100TAF15_26573619_Chip-Seq_HEK293_Human1.11073063
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10667256
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09337840
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08930813
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.08104842
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08004568
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06646517
107* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06247916
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06142908
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.05701432
110* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03513232
111* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02867257
112CJUN_26792858_Chip-Seq_BT549_Human1.02245100
113EWS_26573619_Chip-Seq_HEK293_Human1.02127003
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02032852
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99212635
116RUNX2_22187159_ChIP-Seq_PCA_Human0.99099541
117SOX9_26525672_Chip-Seq_HEART_Mouse0.98578039
118AR_19668381_ChIP-Seq_PC3_Human0.97590826
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97409385
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.97318298
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96645098
122STAT3_23295773_ChIP-Seq_U87_Human0.96545166
123TCF4_23295773_ChIP-Seq_U87_Human0.96335083
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95060281
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94628473
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93680423
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.93590028
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93539122
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92564147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.29597459
2MP0004145_abnormal_muscle_electrophysio4.66118947
3MP0002938_white_spotting3.49921948
4MP0005187_abnormal_penis_morphology3.40206991
5MP0002638_abnormal_pupillary_reflex3.22130959
6MP0009250_abnormal_appendicular_skeleto3.20961103
7MP0000566_synostosis3.12176988
8MP0008438_abnormal_cutaneous_collagen3.04882167
9MP0004272_abnormal_basement_membrane2.97817558
10MP0001299_abnormal_eye_distance/2.96196590
11MP0002282_abnormal_trachea_morphology2.81353142
12MP0010030_abnormal_orbit_morphology2.78492110
13MP0003890_abnormal_embryonic-extraembry2.78395180
14MP0003646_muscle_fatigue2.75699301
15MP0003385_abnormal_body_wall2.57343224
16MP0000537_abnormal_urethra_morphology2.56703882
17MP0005248_abnormal_Harderian_gland2.54956457
18MP0003942_abnormal_urinary_system2.46869680
19MP0003787_abnormal_imprinting2.35100006
20MP0005275_abnormal_skin_tensile2.27206368
21MP0004134_abnormal_chest_morphology2.25879681
22MP0002108_abnormal_muscle_morphology2.13736347
23MP0000428_abnormal_craniofacial_morphol2.09543645
24MP0005257_abnormal_intraocular_pressure2.01358483
25MP0005508_abnormal_skeleton_morphology1.97594517
26MP0003938_abnormal_ear_development1.91883009
27MP0002822_catalepsy1.87136842
28MP0001293_anophthalmia1.85182693
29MP0009053_abnormal_anal_canal1.81178646
30MP0003122_maternal_imprinting1.81050762
31MP0003937_abnormal_limbs/digits/tail_de1.78580353
32MP0003941_abnormal_skin_development1.77334417
33MP0000751_myopathy1.72393459
34MP0005423_abnormal_somatic_nervous1.70304025
35MP0005394_taste/olfaction_phenotype1.67165425
36MP0005499_abnormal_olfactory_system1.67165425
37MP0002249_abnormal_larynx_morphology1.66662879
38MP0002295_abnormal_pulmonary_circulatio1.66333791
39MP0005367_renal/urinary_system_phenotyp1.62215618
40MP0000516_abnormal_urinary_system1.62215618
41MP0003755_abnormal_palate_morphology1.61769851
42MP0000049_abnormal_middle_ear1.58604036
43MP0002116_abnormal_craniofacial_bone1.58330370
44MP0003705_abnormal_hypodermis_morpholog1.55555296
45MP0001346_abnormal_lacrimal_gland1.54872856
46MP0000749_muscle_degeneration1.54401859
47MP0000955_abnormal_spinal_cord1.54074150
48MP0003935_abnormal_craniofacial_develop1.53672202
49MP0002932_abnormal_joint_morphology1.51971714
50MP0000534_abnormal_ureter_morphology1.50451728
51MP0001984_abnormal_olfaction1.49280251
52MP0000163_abnormal_cartilage_morphology1.47241241
53MP0000762_abnormal_tongue_morphology1.46260489
54MP0002109_abnormal_limb_morphology1.44719819
55MP0002115_abnormal_skeleton_extremities1.44435499
56MP0003123_paternal_imprinting1.44379708
57MP0010368_abnormal_lymphatic_system1.43275203
58MP0008789_abnormal_olfactory_epithelium1.42793852
59MP0006292_abnormal_olfactory_placode1.42730385
60MP0000579_abnormal_nail_morphology1.40947765
61MP0006072_abnormal_retinal_apoptosis1.39739308
62MP0002102_abnormal_ear_morphology1.39591518
63MP0000427_abnormal_hair_cycle1.38225344
64MP0002752_abnormal_somatic_nervous1.37390949
65MP0004215_abnormal_myocardial_fiber1.36902972
66MP0002177_abnormal_outer_ear1.35444213
67MP0005551_abnormal_eye_electrophysiolog1.34912773
68MP0001177_atelectasis1.34028483
69MP0005253_abnormal_eye_physiology1.32410111
70MP0002653_abnormal_ependyma_morphology1.32272204
71MP0002160_abnormal_reproductive_system1.31947033
72MP0000462_abnormal_digestive_system1.31837457
73MP0009384_cardiac_valve_regurgitation1.29907834
74MP0002106_abnormal_muscle_physiology1.29693214
75MP0010386_abnormal_urinary_bladder1.29121214
76MP0003279_aneurysm1.28865146
77MP0001661_extended_life_span1.28665109
78MP0002127_abnormal_cardiovascular_syste1.28083036
79MP0002882_abnormal_neuron_morphology1.26019072
80MP0001529_abnormal_vocalization1.25298984
81MP0001188_hyperpigmentation1.24835371
82MP0004270_analgesia1.21037581
83MP0000432_abnormal_head_morphology1.20328028
84MP0000647_abnormal_sebaceous_gland1.19844566
85MP0002896_abnormal_bone_mineralization1.19274588
86MP0002272_abnormal_nervous_system1.17365223
87MP0004084_abnormal_cardiac_muscle1.16748706
88MP0003567_abnormal_fetal_cardiomyocyte1.15818236
89MP0001340_abnormal_eyelid_morphology1.15715460
90MP0002557_abnormal_social/conspecific_i1.15580892
91MP0005620_abnormal_muscle_contractility1.13611365
92MP0002114_abnormal_axial_skeleton1.11142167
93MP0004811_abnormal_neuron_physiology1.10938395
94MP0002152_abnormal_brain_morphology1.10111926
95MP0003119_abnormal_digestive_system1.10060016
96MP0002063_abnormal_learning/memory/cond1.10043024
97MP0005409_darkened_coat_color1.09333848
98MP0004036_abnormal_muscle_relaxation1.08842208
99MP0003115_abnormal_respiratory_system1.08595935
100MP0002928_abnormal_bile_duct1.07562583
101MP0004142_abnormal_muscle_tone1.07262995
102MP0002734_abnormal_mechanical_nocicepti1.06951584
103MP0004130_abnormal_muscle_cell1.05530950
104MP0001958_emphysema1.04905416
105MP0003137_abnormal_impulse_conducting1.04774263
106MP0005369_muscle_phenotype1.04687019
107MP0004859_abnormal_synaptic_plasticity1.02204176
108MP0002233_abnormal_nose_morphology1.00516268
109MP0002067_abnormal_sensory_capabilities1.00482916
110MP0003121_genomic_imprinting1.00299250
111MP0000631_abnormal_neuroendocrine_gland0.99443303
112MP0005330_cardiomyopathy0.98665696
113MP0002113_abnormal_skeleton_development0.97456063
114MP0000639_abnormal_adrenal_gland0.97319332
115MP0005595_abnormal_vascular_smooth0.96520109
116MP0009046_muscle_twitch0.96136409
117MP0005195_abnormal_posterior_eye0.92926441
118MP0000538_abnormal_urinary_bladder0.92031989
119MP0002089_abnormal_postnatal_growth/wei0.91138454
120MP0001243_abnormal_dermal_layer0.90733306
121MP0000750_abnormal_muscle_regeneration0.90483007
122MP0004085_abnormal_heartbeat0.89957249
123MP0009780_abnormal_chondrocyte_physiolo0.88830595
124MP0002572_abnormal_emotion/affect_behav0.88722337
125MP0005391_vision/eye_phenotype0.85929562
126MP0002111_abnormal_tail_morphology0.85121979
127MP0009745_abnormal_behavioral_response0.84892420
128MP0003011_delayed_dark_adaptation0.83466911
129MP0001485_abnormal_pinna_reflex0.83088866
130MP0004133_heterotaxia0.82211031
131MP0001486_abnormal_startle_reflex0.81678811
132MP0002234_abnormal_pharynx_morphology0.81482939
133MP0002972_abnormal_cardiac_muscle0.78738207
134MP0000778_abnormal_nervous_system0.78339285
135MP0002098_abnormal_vibrissa_morphology0.77826085
136MP0004087_abnormal_muscle_fiber0.77202484
137MP0002092_abnormal_eye_morphology0.77182042
138MP0005389_reproductive_system_phenotype0.77133345
139MP0002837_dystrophic_cardiac_calcinosis0.77036949
140MP0000747_muscle_weakness0.76880376
141MP0003943_abnormal_hepatobiliary_system0.75037887
142MP0004858_abnormal_nervous_system0.73090385
143MP0002254_reproductive_system_inflammat0.72942458
144MP0000026_abnormal_inner_ear0.72648325
145MP0005220_abnormal_exocrine_pancreas0.71600404
146MP0002168_other_aberrant_phenotype0.71491306
147MP0005171_absent_coat_pigmentation0.71206944
148MP0003635_abnormal_synaptic_transmissio0.69505673
149MP0003880_abnormal_central_pattern0.69365697
150MP0005075_abnormal_melanosome_morpholog0.68897678
151MP0000733_abnormal_muscle_development0.68046259
152MP0006276_abnormal_autonomic_nervous0.67606058
153MP0003861_abnormal_nervous_system0.65781240
154MP0008775_abnormal_heart_ventricle0.64350497
155MP0005023_abnormal_wound_healing0.63324536
156MP0000383_abnormal_hair_follicle0.62979862
157MP0002133_abnormal_respiratory_system0.62836551
158MP0005388_respiratory_system_phenotype0.62836551
159MP0002081_perinatal_lethality0.62480613
160MP0005390_skeleton_phenotype0.62051025
161MP0000767_abnormal_smooth_muscle0.60368356
162MP0003936_abnormal_reproductive_system0.60234002
163MP0002751_abnormal_autonomic_nervous0.59690697
164MP0001175_abnormal_lung_morphology0.59016957
165MP0002925_abnormal_cardiovascular_devel0.58263686
166MP0002184_abnormal_innervation0.53709837

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)6.40520685
2Midline defect of the nose (HP:0004122)6.00763383
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.77926621
4Short 4th metacarpal (HP:0010044)5.77926621
5Trigonocephaly (HP:0000243)4.48839486
6Nasolacrimal duct obstruction (HP:0000579)4.32362405
7Abnormality of the 4th metacarpal (HP:0010012)4.20382804
8Broad metatarsal (HP:0001783)4.11532070
9Shallow orbits (HP:0000586)4.10115140
10Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.92769236
11Abnormal pancreas size (HP:0012094)3.91493382
12Vitreoretinal degeneration (HP:0000655)3.82764029
13Toxemia of pregnancy (HP:0100603)3.75764270
14Abnormality of the lacrimal duct (HP:0011481)3.65683701
15Pancreatic fibrosis (HP:0100732)3.63678662
16Abnormality of the nasolacrimal system (HP:0000614)3.52973214
17True hermaphroditism (HP:0010459)3.49655803
18Abnormality of the nasal septum (HP:0000419)3.46283634
19Muscle fiber inclusion bodies (HP:0100299)3.45675726
20Anteriorly placed anus (HP:0001545)3.39445473
21Nemaline bodies (HP:0003798)3.39436464
22Abnormality of the calf musculature (HP:0001430)3.39312787
23Aplasia involving bones of the extremities (HP:0009825)3.33673583
24Aplasia involving bones of the upper limbs (HP:0009823)3.33673583
25Aplasia of the phalanges of the hand (HP:0009802)3.33673583
26Protrusio acetabuli (HP:0003179)3.33191962
27Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.32088017
28Gait imbalance (HP:0002141)3.30583766
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.28318977
30Medial flaring of the eyebrow (HP:0010747)3.17037470
31Pancreatic cysts (HP:0001737)3.11999071
32Coronal craniosynostosis (HP:0004440)3.11818949
33Microglossia (HP:0000171)3.10788347
34Congenital primary aphakia (HP:0007707)3.07410922
35Myokymia (HP:0002411)3.05569134
36Alacrima (HP:0000522)3.01077710
37Abnormality of incisor morphology (HP:0011063)2.99868049
38Muscle hypertrophy of the lower extremities (HP:0008968)2.97794353
39Exercise-induced muscle cramps (HP:0003710)2.95490528
40Partial duplication of the phalanx of hand (HP:0009999)2.95094806
41Vaginal atresia (HP:0000148)2.93309209
42Calf muscle hypertrophy (HP:0008981)2.92870561
43Infantile muscular hypotonia (HP:0008947)2.89305460
44Nephronophthisis (HP:0000090)2.86514202
45Exostoses (HP:0100777)2.85013365
46Molar tooth sign on MRI (HP:0002419)2.84220094
47Abnormality of midbrain morphology (HP:0002418)2.84220094
48Genital tract atresia (HP:0001827)2.83308448
49Neoplasm of the heart (HP:0100544)2.82816556
50Short phalanx of the thumb (HP:0009660)2.79667838
51Nephrogenic diabetes insipidus (HP:0009806)2.79255409
52Abnormality of the diencephalon (HP:0010662)2.79112190
53Synostosis involving the elbow (HP:0003938)2.78684824
54Humeroradial synostosis (HP:0003041)2.78684824
55Concave nail (HP:0001598)2.77518853
56Broad toe (HP:0001837)2.74470715
57Broad face (HP:0000283)2.74258408
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.73444527
59Bell-shaped thorax (HP:0001591)2.73206816
60Partial duplication of thumb phalanx (HP:0009944)2.72707943
61Flat capital femoral epiphysis (HP:0003370)2.70961297
62Abnormality of the labia minora (HP:0012880)2.67515919
63Occipital encephalocele (HP:0002085)2.67230213
64Aplasia cutis congenita (HP:0001057)2.66202718
65Peritonitis (HP:0002586)2.65683414
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.64805709
67Cystic liver disease (HP:0006706)2.64262015
68Abnormality of the incisor (HP:0000676)2.63214305
69Supernumerary spleens (HP:0009799)2.59400496
70Broad hallux (HP:0010055)2.58699184
71Polyphagia (HP:0002591)2.57996076
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56685550
73Sparse lateral eyebrow (HP:0005338)2.55857442
74Ulnar deviation of the wrist (HP:0003049)2.54547534
75Type 1 muscle fiber predominance (HP:0003803)2.52951491
76Turricephaly (HP:0000262)2.52405872
77Rimmed vacuoles (HP:0003805)2.51531685
78Narrow forehead (HP:0000341)2.48609222
79Down-sloping shoulders (HP:0200021)2.46351777
80Increased hepatocellular lipid droplets (HP:0006565)2.45974431
81Abnormal respiratory motile cilium physiology (HP:0012261)2.45772711
82White forelock (HP:0002211)2.44865203
83Anophthalmia (HP:0000528)2.43479680
84Abnormality of the renal medulla (HP:0100957)2.42469471
85Mesomelia (HP:0003027)2.41291094
86Lipid accumulation in hepatocytes (HP:0006561)2.39803433
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.36028497
88Drooling (HP:0002307)2.36019241
89Recurrent corneal erosions (HP:0000495)2.35495556
90Chronic hepatic failure (HP:0100626)2.34967010
91Adrenal hypoplasia (HP:0000835)2.33081255
92Wrist flexion contracture (HP:0001239)2.32883563
93Narrow palate (HP:0000189)2.32866157
94Large earlobe (HP:0009748)2.32508699
95Tubulointerstitial abnormality (HP:0001969)2.32440324
96Abnormal respiratory motile cilium morphology (HP:0005938)2.32087255
97Abnormal respiratory epithelium morphology (HP:0012253)2.32087255
98Abnormality of the middle phalanges of the hand (HP:0009833)2.31725049
99Hypoplastic ischia (HP:0003175)2.31116257
100Decreased lacrimation (HP:0000633)2.30747300
101Hepatoblastoma (HP:0002884)2.29334151
102Cortical dysplasia (HP:0002539)2.29295335
103Abnormal number of incisors (HP:0011064)2.27633436
104Increased number of teeth (HP:0011069)2.26588797
105Supernumerary ribs (HP:0005815)2.25868432
106Poor coordination (HP:0002370)2.24825510
107Hypoplastic labia majora (HP:0000059)2.24403719
108Anosmia (HP:0000458)2.23862681
109Anencephaly (HP:0002323)2.23638590
110Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22726834
111Wide anterior fontanel (HP:0000260)2.22501864
112Tubulointerstitial nephritis (HP:0001970)2.22484774
113Abnormality of the ischium (HP:0003174)2.21085738
114Hip contracture (HP:0003273)2.20652044
115Aplasia/Hypoplasia of the spleen (HP:0010451)2.20629110
116Rectovaginal fistula (HP:0000143)2.20292773
117Rectal fistula (HP:0100590)2.20292773
118Tubulointerstitial fibrosis (HP:0005576)2.17843638
119Bronchomalacia (HP:0002780)2.17670278
120Hip dysplasia (HP:0001385)2.17133270
121Sclerocornea (HP:0000647)2.16405054
122Abnormality of the middle phalanges of the toes (HP:0010183)2.15580463
123Disproportionate short-trunk short stature (HP:0003521)2.15357519
124Hypoplasia of the brainstem (HP:0002365)2.14991828
125Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14991828
126Abnormal ciliary motility (HP:0012262)2.12096065
127Excessive salivation (HP:0003781)2.09047498
128Chorioretinal atrophy (HP:0000533)2.08647212
129Aqueductal stenosis (HP:0002410)2.08325387
130Tubular atrophy (HP:0000092)2.08259857
131Growth hormone deficiency (HP:0000824)2.08221120
132Patchy hypopigmentation of hair (HP:0011365)2.07913282
133Left ventricular hypertrophy (HP:0001712)2.06357357
134Febrile seizures (HP:0002373)2.06308140
135Diastasis recti (HP:0001540)2.06290284
136Bilateral microphthalmos (HP:0007633)2.05832631
137Conical tooth (HP:0000698)2.05676827
138Renal Fanconi syndrome (HP:0001994)2.04438190
139Depressed nasal tip (HP:0000437)2.03439555
140Rhinitis (HP:0012384)2.03221314
141Postaxial foot polydactyly (HP:0001830)2.01258770
142Premature rupture of membranes (HP:0001788)2.00260142
143Abnormality of the labia majora (HP:0012881)1.98867889
144Intestinal fistula (HP:0100819)1.98251076
145Atonic seizures (HP:0010819)1.97881974
146Supernumerary bones of the axial skeleton (HP:0009144)1.97465378
147Preaxial foot polydactyly (HP:0001841)1.96907387
148Limited hip movement (HP:0008800)1.95772923
149Hypoplasia of the maxilla (HP:0000327)1.95635119
150Bifid tongue (HP:0010297)1.95541845
151Short metatarsal (HP:0010743)1.95153321
152Congenital hepatic fibrosis (HP:0002612)1.95037824
153Postaxial hand polydactyly (HP:0001162)1.93993899
154Hypoventilation (HP:0002791)1.93575679
155Decreased skull ossification (HP:0004331)1.91787652
156Abnormality of the lower motor neuron (HP:0002366)1.91268060
157Specific learning disability (HP:0001328)1.90165034
158Prominent supraorbital ridges (HP:0000336)1.90073750
159Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.89842341
160Broad thumb (HP:0011304)1.89295431
161Cutaneous finger syndactyly (HP:0010554)1.88948952
162Abnormal hand bone ossification (HP:0010660)1.88846111
163Intellectual disability, moderate (HP:0002342)1.88592974
164Broad long bones (HP:0005622)1.87660398
165Aortic dissection (HP:0002647)1.87520900
166Omphalocele (HP:0001539)1.87515407
167Abnormal ossification of hand bones (HP:0005921)1.86671212
168Labial hypoplasia (HP:0000066)1.86400716
169Impaired vibration sensation in the lower limbs (HP:0002166)1.86355011
170Polymicrogyria (HP:0002126)1.85745353
171Broad foot (HP:0001769)1.85635014
172Asplenia (HP:0001746)1.84800812
173Abnormality of the antihelix (HP:0009738)1.84141535
174Vaginal fistula (HP:0004320)1.84088928
175Hyperextensible skin (HP:0000974)1.82906874
176Choanal stenosis (HP:0000452)1.82883606
177Broad phalanx (HP:0006009)1.82449621
178Distal arthrogryposis (HP:0005684)1.81213569
179Myotonia (HP:0002486)1.81070907
180Amblyopia (HP:0000646)1.80776954
181Mixed hearing impairment (HP:0000410)1.79661448
182Exercise-induced myalgia (HP:0003738)1.78792953
183Aplasia/Hypoplasia of the lens (HP:0008063)1.78450412
184Fetal akinesia sequence (HP:0001989)1.74001616
185Abnormality of the aortic arch (HP:0012303)1.73970260
186Double outlet right ventricle (HP:0001719)1.73516449
187Congenital malformation of the right heart (HP:0011723)1.73516449
188Difficulty running (HP:0009046)1.71931738
189Micropenis (HP:0000054)1.71902773
190Hyperphosphaturia (HP:0003109)1.71665341
191Oligodactyly (hands) (HP:0001180)1.71523681
192Rib fusion (HP:0000902)1.71291000
193Preaxial hand polydactyly (HP:0001177)1.67916753
194Spastic tetraplegia (HP:0002510)1.66095327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.24529660
2DDR24.89581501
3LATS14.55159368
4LATS23.19260005
5EPHA43.02908015
6PINK12.89692155
7MAP4K22.72017037
8TNIK2.49166685
9FGFR12.47889859
10NTRK32.47377747
11PLK22.44089735
12TRIM282.42074707
13PIK3CA2.37188388
14PDGFRA2.32981288
15SIK12.29884328
16EPHA32.18544598
17DYRK32.16315804
18NUAK12.14283363
19WNK32.04785913
20FER2.04298230
21CASK1.92647283
22PKN21.91108142
23EPHB21.90646711
24FRK1.71840565
25PTK2B1.69807129
26AKT31.53050540
27DMPK1.52762617
28PHKG21.48894884
29PHKG11.48894884
30MAP2K41.43313869
31CAMK1G1.38265403
32PRPF4B1.35164974
33FLT31.29879179
34STK31.28981543
35DYRK1B1.28016549
36MYLK1.25373296
37PDGFRB1.23306761
38BMPR1B1.23129468
39BRD41.22189107
40MAP3K41.21316765
41BMX1.18352596
42PBK1.17680204
43LIMK11.13881812
44MAP3K121.12064465
45NLK1.09098962
46STK38L1.02326317
47EPHB11.01724954
48MINK11.01437058
49CSNK1G20.99868014
50CAMK1D0.99038969
51STK240.98056212
52SIK20.97580121
53SGK2230.96361733
54SGK4940.96361733
55KSR10.95453333
56BCKDK0.93927237
57NME10.92767770
58MAPK130.92271937
59PRKD30.91336573
60MAP3K90.90074645
61PNCK0.89973653
62CAMK40.87799244
63PRKCE0.83777703
64MARK10.81706980
65CSNK1G30.81204062
66NTRK10.80480760
67TAOK20.76257860
68RIPK40.73110269
69ADRBK10.72777586
70CSNK1G10.70414294
71MAP3K70.68596378
72ICK0.68162439
73PRKCG0.68111471
74ARAF0.66110196
75STK390.66086348
76PTK20.65944292
77PRKAA10.65826570
78PAK20.65336781
79MAPK70.65066135
80ERBB30.64507218
81ROCK20.64466568
82MAP2K70.63269829
83DYRK20.63195863
84CDC42BPA0.62936127
85PAK30.62215374
86PLK40.62012585
87STK110.61454827
88ROCK10.60973903
89OBSCN0.60925745
90SGK20.60454052
91MST1R0.59941658
92MET0.59644806
93CSNK1A1L0.59385208
94GRK10.59356126
95PKN10.58991592
96RPS6KA20.57755286
97GRK50.57602847
98SGK30.57122911
99RET0.55821278
100NTRK20.55709005
101CAMK2A0.54608200
102PLK30.53319550
103CDK50.51933790
104MAP3K60.51016982
105PRKG10.50680524
106TIE10.50386932
107ADRBK20.48919622
108WNK10.48502362
109RIPK10.48340897
110BRAF0.48187393
111CAMK10.47637021
112WNK40.46440203
113CDK140.46302235
114SRPK10.46262359
115PRKACA0.45560327
116OXSR10.45445718
117CDK180.44976962
118MAPK120.44061600
119CAMKK20.42675824
120TTN0.41755202
121MAP2K10.41485255
122MAP3K20.41371037
123SIK30.39115763
124BMPR20.38696027
125EIF2AK20.38602808
126CDK150.38197660
127STK160.38064145
128PRKD10.37344655
129TYRO30.37032490
130CDK11A0.36870706
131IGF1R0.36504053
132MARK20.36149260
133MAPK150.35432030
134MTOR0.34849974
135MKNK20.34224093
136CAMK2B0.34014227
137DYRK1A0.33504879
138PRKCZ0.33253976
139PAK60.32987376
140PRKCH0.32605625
141FGR0.32083542
142DAPK20.31687662
143BCR0.31551680
144ERBB20.30262402
145SRC0.28956643
146FYN0.28941375
147CSNK1A10.28755619
148SGK10.28586354
149MAP3K110.27900096
150PRKCQ0.27708687
151TGFBR20.27418429
152INSR0.25835161
153MAPK80.25630594

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.63507184
2Hedgehog signaling pathway_Homo sapiens_hsa043404.18564908
3Wnt signaling pathway_Homo sapiens_hsa043102.45683053
4ECM-receptor interaction_Homo sapiens_hsa045122.33969749
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.09768991
6Nicotine addiction_Homo sapiens_hsa050332.06076310
7TGF-beta signaling pathway_Homo sapiens_hsa043502.05574828
8Melanoma_Homo sapiens_hsa052182.03584450
9Oxidative phosphorylation_Homo sapiens_hsa001901.97271136
10Axon guidance_Homo sapiens_hsa043601.91989466
11Parkinsons disease_Homo sapiens_hsa050121.87845909
12Hippo signaling pathway_Homo sapiens_hsa043901.86833006
13Renin secretion_Homo sapiens_hsa049241.86678467
14Propanoate metabolism_Homo sapiens_hsa006401.84264499
15Adherens junction_Homo sapiens_hsa045201.80205888
16Long-term potentiation_Homo sapiens_hsa047201.75832186
17Melanogenesis_Homo sapiens_hsa049161.74145132
18Protein export_Homo sapiens_hsa030601.74007514
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69777261
20Dilated cardiomyopathy_Homo sapiens_hsa054141.69157245
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68296658
22Phototransduction_Homo sapiens_hsa047441.67672069
23Amphetamine addiction_Homo sapiens_hsa050311.64577408
24Circadian entrainment_Homo sapiens_hsa047131.61774979
25Steroid biosynthesis_Homo sapiens_hsa001001.60320205
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54495997
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54108282
28Focal adhesion_Homo sapiens_hsa045101.53839741
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52332743
30Proteoglycans in cancer_Homo sapiens_hsa052051.48924930
31Glutamatergic synapse_Homo sapiens_hsa047241.46038686
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44888335
33Pathways in cancer_Homo sapiens_hsa052001.39302072
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37875370
35cAMP signaling pathway_Homo sapiens_hsa040241.35996399
36Circadian rhythm_Homo sapiens_hsa047101.31507209
37Long-term depression_Homo sapiens_hsa047301.30416069
38Huntingtons disease_Homo sapiens_hsa050161.30136023
39Prostate cancer_Homo sapiens_hsa052151.30033240
40Protein digestion and absorption_Homo sapiens_hsa049741.27672126
41Rap1 signaling pathway_Homo sapiens_hsa040151.24962387
42Oxytocin signaling pathway_Homo sapiens_hsa049211.22249783
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21797356
44Dopaminergic synapse_Homo sapiens_hsa047281.18677745
45Amoebiasis_Homo sapiens_hsa051461.16589220
46Cocaine addiction_Homo sapiens_hsa050301.13825566
47GABAergic synapse_Homo sapiens_hsa047271.12048487
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11849279
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11770994
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11252754
51Calcium signaling pathway_Homo sapiens_hsa040201.11222502
52Gap junction_Homo sapiens_hsa045401.10568756
53Salivary secretion_Homo sapiens_hsa049701.10146888
54Morphine addiction_Homo sapiens_hsa050321.08277692
55Colorectal cancer_Homo sapiens_hsa052101.04953566
56GnRH signaling pathway_Homo sapiens_hsa049121.03233667
57Cholinergic synapse_Homo sapiens_hsa047251.03063587
58Ras signaling pathway_Homo sapiens_hsa040141.00255932
59Glioma_Homo sapiens_hsa052140.99056971
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98793050
61MAPK signaling pathway_Homo sapiens_hsa040100.96736312
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.94617416
63ErbB signaling pathway_Homo sapiens_hsa040120.93775577
64Pyruvate metabolism_Homo sapiens_hsa006200.92994319
65Regulation of autophagy_Homo sapiens_hsa041400.92932462
66Serotonergic synapse_Homo sapiens_hsa047260.92746875
67MicroRNAs in cancer_Homo sapiens_hsa052060.92324616
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.90151480
69Fatty acid metabolism_Homo sapiens_hsa012120.88429402
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88293674
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87488325
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85447099
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84300680
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84244130
75Butanoate metabolism_Homo sapiens_hsa006500.84139337
76Cardiac muscle contraction_Homo sapiens_hsa042600.83281650
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82136407
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80540024
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79842372
80Endometrial cancer_Homo sapiens_hsa052130.79426165
81Estrogen signaling pathway_Homo sapiens_hsa049150.78985174
82Type II diabetes mellitus_Homo sapiens_hsa049300.74665116
83Gastric acid secretion_Homo sapiens_hsa049710.74001415
84Nitrogen metabolism_Homo sapiens_hsa009100.73603648
85beta-Alanine metabolism_Homo sapiens_hsa004100.73248155
86Taste transduction_Homo sapiens_hsa047420.73137114
87Insulin secretion_Homo sapiens_hsa049110.72824673
88Olfactory transduction_Homo sapiens_hsa047400.71626278
89Lysine degradation_Homo sapiens_hsa003100.70735515
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70192219
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69840604
92Glycerolipid metabolism_Homo sapiens_hsa005610.66954076
93Arginine and proline metabolism_Homo sapiens_hsa003300.66657091
94Ovarian steroidogenesis_Homo sapiens_hsa049130.65807424
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64521786
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64237024
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63787660
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63380141
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63280438
100Choline metabolism in cancer_Homo sapiens_hsa052310.61881173
101Alcoholism_Homo sapiens_hsa050340.61483599
102Complement and coagulation cascades_Homo sapiens_hsa046100.60401842
103Glucagon signaling pathway_Homo sapiens_hsa049220.60110654
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57023383
105Fatty acid degradation_Homo sapiens_hsa000710.56900417
106Synaptic vesicle cycle_Homo sapiens_hsa047210.55955448
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55772645
108Small cell lung cancer_Homo sapiens_hsa052220.55229656
109Phenylalanine metabolism_Homo sapiens_hsa003600.54980285
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54548402
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53895899
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53776761
113Peroxisome_Homo sapiens_hsa041460.52994316
114Tryptophan metabolism_Homo sapiens_hsa003800.52287952
115Renal cell carcinoma_Homo sapiens_hsa052110.51975764
116Fanconi anemia pathway_Homo sapiens_hsa034600.51370827
117Linoleic acid metabolism_Homo sapiens_hsa005910.49337979
118Fatty acid elongation_Homo sapiens_hsa000620.48707976
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48523157
120Fatty acid biosynthesis_Homo sapiens_hsa000610.45906060
121Collecting duct acid secretion_Homo sapiens_hsa049660.44043125
122Notch signaling pathway_Homo sapiens_hsa043300.43617432
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43240107
124Oocyte meiosis_Homo sapiens_hsa041140.42947678
125Prion diseases_Homo sapiens_hsa050200.41899144
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.41271911
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41180484
128Thyroid hormone synthesis_Homo sapiens_hsa049180.40306372
129Thyroid cancer_Homo sapiens_hsa052160.38834142
130Fat digestion and absorption_Homo sapiens_hsa049750.38729847
131Tight junction_Homo sapiens_hsa045300.38040935
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.37372273
133Carbon metabolism_Homo sapiens_hsa012000.36869127
134African trypanosomiasis_Homo sapiens_hsa051430.34972372
135Bladder cancer_Homo sapiens_hsa052190.34012527
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33981346
137Viral myocarditis_Homo sapiens_hsa054160.33854729
138HTLV-I infection_Homo sapiens_hsa051660.31084843
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30010758
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.29299732
141Alzheimers disease_Homo sapiens_hsa050100.28933867
142AMPK signaling pathway_Homo sapiens_hsa041520.28266202

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