RSRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.79284019
2axon ensheathment in central nervous system (GO:0032291)6.79284019
3water-soluble vitamin biosynthetic process (GO:0042364)4.82813457
4protein complex biogenesis (GO:0070271)4.81762661
5long-chain fatty acid biosynthetic process (GO:0042759)4.69215316
6behavioral response to nicotine (GO:0035095)4.62747326
7DNA deamination (GO:0045006)4.60032977
8mitochondrial respiratory chain complex assembly (GO:0033108)4.54200158
9fatty acid elongation (GO:0030497)4.43910947
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15590179
11limb bud formation (GO:0060174)4.08622443
12ATP synthesis coupled proton transport (GO:0015986)3.84732348
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84732348
14presynaptic membrane assembly (GO:0097105)3.75516495
15indole-containing compound catabolic process (GO:0042436)3.66923680
16indolalkylamine catabolic process (GO:0046218)3.66923680
17tryptophan catabolic process (GO:0006569)3.66923680
18polyketide metabolic process (GO:0030638)3.66699937
19doxorubicin metabolic process (GO:0044598)3.66699937
20daunorubicin metabolic process (GO:0044597)3.66699937
21response to pheromone (GO:0019236)3.63903577
22respiratory chain complex IV assembly (GO:0008535)3.63324149
23presynaptic membrane organization (GO:0097090)3.62588093
24kynurenine metabolic process (GO:0070189)3.61981209
25myelination (GO:0042552)3.57891191
26protein K6-linked ubiquitination (GO:0085020)3.56345288
27regulation of collateral sprouting (GO:0048670)3.53670012
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.49853005
29ensheathment of neurons (GO:0007272)3.45618473
30axon ensheathment (GO:0008366)3.45618473
31electron transport chain (GO:0022900)3.44768884
32respiratory electron transport chain (GO:0022904)3.44505570
33replication fork processing (GO:0031297)3.41670680
34photoreceptor cell differentiation (GO:0046530)3.40665164
35eye photoreceptor cell differentiation (GO:0001754)3.40665164
36lateral sprouting from an epithelium (GO:0060601)3.38915149
37cytochrome complex assembly (GO:0017004)3.38428608
38chromatin remodeling at centromere (GO:0031055)3.37808570
39tryptophan metabolic process (GO:0006568)3.37648530
40protein neddylation (GO:0045116)3.35061879
41platelet dense granule organization (GO:0060155)3.33224605
42maturation of 5.8S rRNA (GO:0000460)3.32045638
43negative regulation of neurotransmitter transport (GO:0051589)3.31649174
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29181962
45indolalkylamine metabolic process (GO:0006586)3.29158362
46double-strand break repair via homologous recombination (GO:0000724)3.28181554
47recombinational repair (GO:0000725)3.27552536
48CENP-A containing nucleosome assembly (GO:0034080)3.25415535
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22909077
50cerebral cortex radially oriented cell migration (GO:0021799)3.22429752
51microtubule polymerization or depolymerization (GO:0031109)3.21289575
52sulfation (GO:0051923)3.21045259
53neuron cell-cell adhesion (GO:0007158)3.17502623
54regulation of mitochondrial translation (GO:0070129)3.16654730
55isoprenoid biosynthetic process (GO:0008299)3.11792021
56DNA double-strand break processing (GO:0000729)3.11460615
57termination of RNA polymerase III transcription (GO:0006386)3.11166165
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.11166165
59regulation of DNA endoreduplication (GO:0032875)3.10369247
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.05539177
61kinetochore organization (GO:0051383)3.04108257
62DNA ligation (GO:0006266)3.03194962
63negative regulation of axon guidance (GO:1902668)2.99918844
64response to redox state (GO:0051775)2.96204114
65histone exchange (GO:0043486)2.94270950
66cholesterol biosynthetic process (GO:0006695)2.92070462
67kinetochore assembly (GO:0051382)2.90438037
68pseudouridine synthesis (GO:0001522)2.90084641
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84807055
70L-fucose catabolic process (GO:0042355)2.84142894
71fucose catabolic process (GO:0019317)2.84142894
72L-fucose metabolic process (GO:0042354)2.84142894
73estrogen biosynthetic process (GO:0006703)2.80491078
74protein-cofactor linkage (GO:0018065)2.80453539
75somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76746367
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76746367
77isotype switching (GO:0045190)2.76746367
78nonmotile primary cilium assembly (GO:0035058)2.70756709
79microtubule depolymerization (GO:0007019)2.67864373
80positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.67732351
81prenylation (GO:0097354)2.65878316
82protein prenylation (GO:0018342)2.65878316
83preassembly of GPI anchor in ER membrane (GO:0016254)2.65140200
84synapsis (GO:0007129)2.64316114
85negative regulation of execution phase of apoptosis (GO:1900118)2.63672257
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63294310
87regulation of hexokinase activity (GO:1903299)2.63282625
88regulation of glucokinase activity (GO:0033131)2.63282625
89resolution of meiotic recombination intermediates (GO:0000712)2.63062440
90protein polyglutamylation (GO:0018095)2.61175514
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56953880
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56953880
93lymphoid progenitor cell differentiation (GO:0002320)2.55941076
94negative regulation of neurotransmitter secretion (GO:0046929)2.55372682
95DNA catabolic process, exonucleolytic (GO:0000738)2.54863322
96hydrogen ion transmembrane transport (GO:1902600)2.54597920
97proteasome assembly (GO:0043248)2.54422867
98dopamine transport (GO:0015872)2.52773077
99intraciliary transport (GO:0042073)2.52519946
100regulation of cilium movement (GO:0003352)2.52419566
101negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52150601
102histone H3-K4 trimethylation (GO:0080182)2.51309275
103RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51239491
104sterol biosynthetic process (GO:0016126)2.50865938
105centriole replication (GO:0007099)2.50217632
106cranial nerve development (GO:0021545)2.50111927
107mitochondrial calcium ion transport (GO:0006851)2.50088927
108magnesium ion transport (GO:0015693)2.49630259
109substantia nigra development (GO:0021762)2.49441262
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47754979
111negative regulation of telomere maintenance (GO:0032205)2.47623135
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46699503
113proton transport (GO:0015992)2.46325043
114DNA strand elongation involved in DNA replication (GO:0006271)2.46138946
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44507807
116retinal ganglion cell axon guidance (GO:0031290)2.44429534
117regulation of mitotic spindle checkpoint (GO:1903504)2.42111165
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42111165
119regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41983652
120negative regulation of stem cell proliferation (GO:2000647)2.41335928
121astrocyte development (GO:0014002)2.41234997
122neurotransmitter uptake (GO:0001504)2.41222328
123hydrogen transport (GO:0006818)2.40914377
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.40145068
125intracellular protein transmembrane import (GO:0044743)2.39741237
126indole-containing compound metabolic process (GO:0042430)2.39428428
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37204312
128signal peptide processing (GO:0006465)2.36934383
129GPI anchor biosynthetic process (GO:0006506)2.36561349
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.36040434
131histone H2B ubiquitination (GO:0033523)2.35420704
132DNA-dependent DNA replication (GO:0006261)2.35040292
133negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.34925626
134axonemal dynein complex assembly (GO:0070286)2.34407406
135aromatic amino acid family catabolic process (GO:0009074)2.33733138
136tRNA processing (GO:0008033)2.33458048
137regulation of cellular amino acid metabolic process (GO:0006521)2.33420059
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.32578675
139negative regulation of axon extension (GO:0030517)2.32367926
140rhodopsin mediated signaling pathway (GO:0016056)2.32092669
141positive regulation of action potential (GO:0045760)2.31770461
142DNA strand elongation (GO:0022616)2.31496266
143negative regulation of appetite (GO:0032099)2.31064649
144negative regulation of response to food (GO:0032096)2.31064649
145neuron remodeling (GO:0016322)2.31060602
146developmental pigmentation (GO:0048066)2.30694481
147rRNA modification (GO:0000154)2.30528898
148GTP biosynthetic process (GO:0006183)2.30155293
149ear development (GO:0043583)2.29876927
150spinal cord motor neuron differentiation (GO:0021522)2.29539832
151prostate gland growth (GO:0060736)2.29530561
152spermatid nucleus differentiation (GO:0007289)2.29043667
153male meiosis I (GO:0007141)2.28531497
154chaperone-mediated protein transport (GO:0072321)2.26184343
155epithelial cilium movement (GO:0003351)2.26028076
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.25377750
157establishment of integrated proviral latency (GO:0075713)2.24702509
158cilium movement (GO:0003341)2.24157605
159negative regulation of myoblast differentiation (GO:0045662)2.23147061
160sphingoid metabolic process (GO:0046519)2.22658312
161pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.22507364
162negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.21922821
163GPI anchor metabolic process (GO:0006505)2.21853990
164detection of light stimulus involved in sensory perception (GO:0050962)2.21615421
165detection of light stimulus involved in visual perception (GO:0050908)2.21615421
166glycerophospholipid catabolic process (GO:0046475)2.19558556
167postsynaptic membrane organization (GO:0001941)2.19439287
168import into cell (GO:0098657)2.17739660
169oligodendrocyte differentiation (GO:0048709)2.16985044
170regulation of cell proliferation involved in kidney development (GO:1901722)2.16323986
171DNA topological change (GO:0006265)2.15560371
172regulation of catecholamine metabolic process (GO:0042069)2.15550960
173regulation of dopamine metabolic process (GO:0042053)2.15550960
174cell fate commitment involved in formation of primary germ layer (GO:0060795)2.14349467
175L-amino acid import (GO:0043092)2.13621169
176apical protein localization (GO:0045176)2.13602558
177negative regulation of acute inflammatory response (GO:0002674)2.13183462
178ER overload response (GO:0006983)2.13132850
179mannosylation (GO:0097502)2.13016003
180negative regulation of protein localization to cell surface (GO:2000009)2.12774430
181protein localization to cilium (GO:0061512)2.12455389
182mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.11981772
183mitochondrial respiratory chain complex I assembly (GO:0032981)2.11981772
184NADH dehydrogenase complex assembly (GO:0010257)2.11981772
185glial cell development (GO:0021782)2.11877372
186centriole assembly (GO:0098534)2.11475656
187cilium or flagellum-dependent cell motility (GO:0001539)2.11428294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.55153039
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38144795
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.04643894
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.04093291
5EZH2_22144423_ChIP-Seq_EOC_Human3.01027351
6ZNF274_21170338_ChIP-Seq_K562_Hela2.74956731
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73247086
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69226111
9TAF15_26573619_Chip-Seq_HEK293_Human2.53280426
10VDR_22108803_ChIP-Seq_LS180_Human2.45244993
11ELK1_19687146_ChIP-ChIP_HELA_Human2.43724501
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27237365
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.23140510
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15393494
15FUS_26573619_Chip-Seq_HEK293_Human2.10459116
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08349250
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04581543
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.02211387
19MYC_18940864_ChIP-ChIP_HL60_Human2.01709266
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.98991528
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98904563
22* VDR_23849224_ChIP-Seq_CD4+_Human1.95104223
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94385012
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93861361
25IGF1R_20145208_ChIP-Seq_DFB_Human1.92070572
26E2F7_22180533_ChIP-Seq_HELA_Human1.91625972
27EWS_26573619_Chip-Seq_HEK293_Human1.89040468
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88878724
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.87631513
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85799985
31P300_19829295_ChIP-Seq_ESCs_Human1.85112429
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.84438586
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84300060
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80832967
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79713253
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77132346
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76983584
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.76769316
39RNF2_27304074_Chip-Seq_NSC_Mouse1.76304023
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73602819
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71833098
42ER_23166858_ChIP-Seq_MCF-7_Human1.71066133
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69615995
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68952721
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.68742371
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65702506
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64360655
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61626979
49* FOXP3_21729870_ChIP-Seq_TREG_Human1.59393167
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59067445
51* SRF_21415370_ChIP-Seq_HL-1_Mouse1.59008160
52P53_22387025_ChIP-Seq_ESCs_Mouse1.58398260
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57548247
54* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56899604
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.56677520
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55640454
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.55552365
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.55062485
59IRF1_19129219_ChIP-ChIP_H3396_Human1.54977944
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53169217
61TP53_22573176_ChIP-Seq_HFKS_Human1.50027916
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49808693
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45943460
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45677215
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45400217
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44916617
67* STAT3_18555785_Chip-Seq_ESCs_Mouse1.42982303
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.42387869
69P300_18555785_Chip-Seq_ESCs_Mouse1.42235306
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41755841
71* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41658577
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41328066
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40746059
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40716488
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.38307036
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37782113
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.36870847
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35627727
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.35614626
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33815777
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33099473
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33099473
83SMAD4_21799915_ChIP-Seq_A2780_Human1.32971888
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32557006
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32327522
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31372249
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31341244
88CBP_20019798_ChIP-Seq_JUKART_Human1.30944316
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30944316
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30383408
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.29161249
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27663835
93NANOG_19829295_ChIP-Seq_ESCs_Human1.26774426
94SOX2_19829295_ChIP-Seq_ESCs_Human1.26774426
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26148146
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25137349
97JUN_21703547_ChIP-Seq_K562_Human1.25090400
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.24957637
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24957637
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24543907
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.24307406
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23571333
103* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23304590
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.22491748
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.21788550
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.19252863
107BCAT_22108803_ChIP-Seq_LS180_Human1.17753429
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.16948965
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15950743
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15620843
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.14224807
112PU1_27457419_Chip-Seq_LIVER_Mouse1.13715124
113* STAT3_23295773_ChIP-Seq_U87_Human1.13485895
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13210565
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13209689
116CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12173432
117SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09633135
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09525460
119CTCF_18555785_Chip-Seq_ESCs_Mouse1.09417546
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.08779896
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08501234
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08407381
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.07953532
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07088734
125AR_21572438_ChIP-Seq_LNCaP_Human1.06695884
126AR_25329375_ChIP-Seq_VCAP_Human1.06205992
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06170367
128SMAD_19615063_ChIP-ChIP_OVARY_Human1.05487837
129* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04307563
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03692996
131SOX9_26525672_Chip-Seq_HEART_Mouse1.02303459
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01809515
133* TCF4_22108803_ChIP-Seq_LS180_Human1.01802148
134TP53_18474530_ChIP-ChIP_U2OS_Human1.01585194
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00984294
136* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00974458
137* TCF4_23295773_ChIP-Seq_U87_Human1.00690168
138RUNX2_22187159_ChIP-Seq_PCA_Human1.00023187
139GABP_17652178_ChIP-ChIP_JURKAT_Human0.99642214
140* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99530897
141AR_20517297_ChIP-Seq_VCAP_Human0.98446171
142NCOR_22424771_ChIP-Seq_293T_Human0.98420741
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96953253
144KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96853748
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96674176
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95378224
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93609775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.87928423
2MP0003195_calcinosis3.34812851
3MP0003880_abnormal_central_pattern3.34135316
4MP0001529_abnormal_vocalization2.92003624
5MP0000569_abnormal_digit_pigmentation2.91166672
6MP0003136_yellow_coat_color2.67635223
7MP0005171_absent_coat_pigmentation2.60568983
8MP0002837_dystrophic_cardiac_calcinosis2.32971173
9MP0004381_abnormal_hair_follicle2.31977642
10MP0006072_abnormal_retinal_apoptosis2.29486947
11MP0008058_abnormal_DNA_repair2.29272795
12MP0010094_abnormal_chromosome_stability2.21161280
13MP0001188_hyperpigmentation2.17463480
14MP0000383_abnormal_hair_follicle2.12528062
15MP0002736_abnormal_nociception_after2.08010347
16MP0001905_abnormal_dopamine_level2.06769439
17MP0002876_abnormal_thyroid_physiology2.06099831
18MP0002938_white_spotting1.99311613
19MP0001968_abnormal_touch/_nociception1.97960980
20MP0003941_abnormal_skin_development1.94773942
21MP0008872_abnormal_physiological_respon1.93776644
22MP0001984_abnormal_olfaction1.90195378
23MP0005084_abnormal_gallbladder_morpholo1.90018177
24MP0002160_abnormal_reproductive_system1.88156916
25MP0000372_irregular_coat_pigmentation1.85115825
26MP0000920_abnormal_myelination1.83449231
27MP0004742_abnormal_vestibular_system1.82331075
28MP0006276_abnormal_autonomic_nervous1.75515208
29MP0002102_abnormal_ear_morphology1.74354937
30MP0009046_muscle_twitch1.73054498
31MP0000778_abnormal_nervous_system1.73030111
32MP0001486_abnormal_startle_reflex1.72256942
33MP0002272_abnormal_nervous_system1.69188588
34MP0003806_abnormal_nucleotide_metabolis1.66636450
35MP0000015_abnormal_ear_pigmentation1.65445270
36MP0001986_abnormal_taste_sensitivity1.64520320
37MP0003786_premature_aging1.59314184
38MP0005389_reproductive_system_phenotype1.54817723
39MP0010386_abnormal_urinary_bladder1.54289471
40MP0005423_abnormal_somatic_nervous1.54046789
41MP0003011_delayed_dark_adaptation1.52630842
42MP0005646_abnormal_pituitary_gland1.52448187
43MP0005409_darkened_coat_color1.51959391
44MP0004134_abnormal_chest_morphology1.50349510
45MP0002064_seizures1.45687924
46MP0009697_abnormal_copulation1.43565122
47MP0000427_abnormal_hair_cycle1.43329516
48MP0008875_abnormal_xenobiotic_pharmacok1.41589131
49MP0003186_abnormal_redox_activity1.41585340
50MP0001485_abnormal_pinna_reflex1.37249664
51MP0010678_abnormal_skin_adnexa1.36656191
52MP0005174_abnormal_tail_pigmentation1.36491243
53MP0005410_abnormal_fertilization1.36281796
54MP0006036_abnormal_mitochondrial_physio1.32833715
55MP0002277_abnormal_respiratory_mucosa1.31291251
56MP0001440_abnormal_grooming_behavior1.30593983
57MP0008995_early_reproductive_senescence1.30211181
58MP0002572_abnormal_emotion/affect_behav1.27862841
59MP0006292_abnormal_olfactory_placode1.27696105
60MP0004142_abnormal_muscle_tone1.27167606
61MP0004885_abnormal_endolymph1.26826523
62MP0009745_abnormal_behavioral_response1.26377463
63MP0004145_abnormal_muscle_electrophysio1.24705826
64MP0005551_abnormal_eye_electrophysiolog1.24569330
65MP0003937_abnormal_limbs/digits/tail_de1.23252465
66MP0002735_abnormal_chemical_nociception1.22551328
67MP0006035_abnormal_mitochondrial_morpho1.22502256
68MP0004215_abnormal_myocardial_fiber1.21364894
69MP0008057_abnormal_DNA_replication1.21069946
70MP0003938_abnormal_ear_development1.19808639
71MP0005075_abnormal_melanosome_morpholog1.19606606
72MP0004147_increased_porphyrin_level1.19165686
73MP0008877_abnormal_DNA_methylation1.18753186
74MP0009379_abnormal_foot_pigmentation1.18296508
75MP0000631_abnormal_neuroendocrine_gland1.18286518
76MP0002734_abnormal_mechanical_nocicepti1.16957993
77MP0003646_muscle_fatigue1.16860373
78MP0002751_abnormal_autonomic_nervous1.15954316
79MP0002067_abnormal_sensory_capabilities1.15559855
80MP0000762_abnormal_tongue_morphology1.12000898
81MP0004133_heterotaxia1.11947324
82MP0001346_abnormal_lacrimal_gland1.10907527
83MP0001929_abnormal_gametogenesis1.09908273
84MP0003111_abnormal_nucleus_morphology1.08755060
85MP0009250_abnormal_appendicular_skeleto1.08598083
86MP0003635_abnormal_synaptic_transmissio1.08386167
87MP0002163_abnormal_gland_morphology1.07949212
88MP0004859_abnormal_synaptic_plasticity1.06760856
89MP0002557_abnormal_social/conspecific_i1.06504219
90MP0008932_abnormal_embryonic_tissue1.05798065
91MP0002928_abnormal_bile_duct1.04158320
92MP0001963_abnormal_hearing_physiology1.03996531
93MP0002177_abnormal_outer_ear1.03964213
94MP0002234_abnormal_pharynx_morphology1.02189817
95MP0003121_genomic_imprinting1.02112831
96MP0002210_abnormal_sex_determination1.00995654
97MP0001944_abnormal_pancreas_morphology1.00940548
98MP0002095_abnormal_skin_pigmentation1.00727080
99MP0001919_abnormal_reproductive_system1.00094116
100MP0008789_abnormal_olfactory_epithelium0.99642242
101MP0003787_abnormal_imprinting0.99219189
102MP0002184_abnormal_innervation0.98249713
103MP0000026_abnormal_inner_ear0.98137507
104MP0008004_abnormal_stomach_pH0.98136734
105MP0002882_abnormal_neuron_morphology0.97860624
106MP0002009_preneoplasia0.97546111
107MP0005332_abnormal_amino_acid0.96934300
108MP0000049_abnormal_middle_ear0.96313336
109MP0003718_maternal_effect0.95857901
110MP0002752_abnormal_somatic_nervous0.95652575
111MP0002063_abnormal_learning/memory/cond0.94387135
112MP0000653_abnormal_sex_gland0.94003062
113MP0003283_abnormal_digestive_organ0.93447276
114MP0000647_abnormal_sebaceous_gland0.92694861
115MP0002693_abnormal_pancreas_physiology0.92186901
116MP0001970_abnormal_pain_threshold0.91784712
117MP0005645_abnormal_hypothalamus_physiol0.91766178
118MP0001145_abnormal_male_reproductive0.91690662
119MP0005503_abnormal_tendon_morphology0.90540140
120MP0005379_endocrine/exocrine_gland_phen0.89245719
121MP0001764_abnormal_homeostasis0.88945160
122MP0005253_abnormal_eye_physiology0.87769680
123MP0001299_abnormal_eye_distance/0.86935081
124MP0000955_abnormal_spinal_cord0.86851398
125MP0009780_abnormal_chondrocyte_physiolo0.85748122
126MP0003698_abnormal_male_reproductive0.85037619
127MP0004270_analgesia0.84740866
128MP0002098_abnormal_vibrissa_morphology0.83725960
129MP0005195_abnormal_posterior_eye0.82719771
130MP0001293_anophthalmia0.82533357
131MP0002638_abnormal_pupillary_reflex0.81843439
132MP0002229_neurodegeneration0.81243502
133MP0005187_abnormal_penis_morphology0.80124368
134MP0002233_abnormal_nose_morphology0.79571304
135MP0005636_abnormal_mineral_homeostasis0.78398141
136MP0003755_abnormal_palate_morphology0.77540008
137MP0001177_atelectasis0.76307658
138MP0001501_abnormal_sleep_pattern0.76283312
139MP0002733_abnormal_thermal_nociception0.76268895
140MP0010771_integument_phenotype0.76201162
141MP0000639_abnormal_adrenal_gland0.76186625
142MP0003693_abnormal_embryo_hatching0.76034277
143MP0003077_abnormal_cell_cycle0.75753147
144MP0005394_taste/olfaction_phenotype0.75504479
145MP0005499_abnormal_olfactory_system0.75504479
146MP0003252_abnormal_bile_duct0.75248543
147MP0004924_abnormal_behavior0.74998413
148MP0005386_behavior/neurological_phenoty0.74998413
149MP0003634_abnormal_glial_cell0.74109920
150MP0002282_abnormal_trachea_morphology0.73790041
151MP0000358_abnormal_cell_content/0.73769845
152MP0003950_abnormal_plasma_membrane0.72909552

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.44544354
2Pancreatic cysts (HP:0001737)4.06596060
3Pancreatic fibrosis (HP:0100732)3.61463876
4Absent/shortened dynein arms (HP:0200106)3.50755582
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.50755582
6Acute encephalopathy (HP:0006846)3.36777006
7Increased CSF lactate (HP:0002490)3.21297779
8Nephronophthisis (HP:0000090)3.13820331
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.11530491
10Abnormal ciliary motility (HP:0012262)3.04372771
11Hypoplastic pelvis (HP:0008839)2.99603301
12Septo-optic dysplasia (HP:0100842)2.90564978
13Lipid accumulation in hepatocytes (HP:0006561)2.86309357
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84279560
15Lip pit (HP:0100267)2.79996972
16Hepatocellular necrosis (HP:0001404)2.74631732
17Abnormal respiratory motile cilium morphology (HP:0005938)2.72631244
18Abnormal respiratory epithelium morphology (HP:0012253)2.72631244
19Pendular nystagmus (HP:0012043)2.72430198
20Abnormality of the renal cortex (HP:0011035)2.72349936
21Medial flaring of the eyebrow (HP:0010747)2.72335667
22Abnormal respiratory motile cilium physiology (HP:0012261)2.72043875
23Hepatic necrosis (HP:0002605)2.69589163
24Congenital, generalized hypertrichosis (HP:0004540)2.65975838
25Abnormality of the renal medulla (HP:0100957)2.61221387
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.57646511
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57646511
28Cupped ear (HP:0000378)2.55411745
29Methylmalonic aciduria (HP:0012120)2.54032280
30White forelock (HP:0002211)2.48190163
31Patchy hypopigmentation of hair (HP:0011365)2.47742961
32Renal cortical cysts (HP:0000803)2.46533545
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.44778213
34Cerebral edema (HP:0002181)2.44558826
35Genital tract atresia (HP:0001827)2.43709486
36Abnormal rod and cone electroretinograms (HP:0008323)2.42943605
37Abnormality of chromosome stability (HP:0003220)2.42878937
38Absent septum pellucidum (HP:0001331)2.42800960
39Vaginal atresia (HP:0000148)2.40737671
40Congenital primary aphakia (HP:0007707)2.38911784
413-Methylglutaconic aciduria (HP:0003535)2.37926907
42Gait imbalance (HP:0002141)2.36574025
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35990855
44Abnormality of alanine metabolism (HP:0010916)2.35990855
45Hyperalaninemia (HP:0003348)2.35990855
46Congenital ichthyosiform erythroderma (HP:0007431)2.33307129
47Renal Fanconi syndrome (HP:0001994)2.32474337
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29847670
49Nephrogenic diabetes insipidus (HP:0009806)2.28610336
50Acute necrotizing encephalopathy (HP:0006965)2.27859335
51Abnormality of the ileum (HP:0001549)2.26285395
52Furrowed tongue (HP:0000221)2.25515890
53Abnormal hair whorl (HP:0010721)2.25435266
54Popliteal pterygium (HP:0009756)2.24603057
55Meckel diverticulum (HP:0002245)2.24045433
56Abnormality of incisor morphology (HP:0011063)2.23864943
57Increased hepatocellular lipid droplets (HP:0006565)2.22157115
58Increased serum lactate (HP:0002151)2.16737957
59Attenuation of retinal blood vessels (HP:0007843)2.16189030
60Absent thumb (HP:0009777)2.15751030
61Retinal dysplasia (HP:0007973)2.15594621
62Decreased central vision (HP:0007663)2.14937890
63Short tibia (HP:0005736)2.14713491
64Abnormality of the septum pellucidum (HP:0007375)2.14351388
65Sclerocornea (HP:0000647)2.13553275
66Duplicated collecting system (HP:0000081)2.13434756
67Septate vagina (HP:0001153)2.12608893
68Hypothermia (HP:0002045)2.12572401
69Sensory axonal neuropathy (HP:0003390)2.10937266
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.08892226
71Irregular epiphyses (HP:0010582)2.07687324
72Congenital stationary night blindness (HP:0007642)2.05145087
73Erythroderma (HP:0001019)2.04983959
74Conjunctival hamartoma (HP:0100780)2.04713756
75Neuroendocrine neoplasm (HP:0100634)2.04708169
76Ketoacidosis (HP:0001993)2.03846576
77Mitochondrial inheritance (HP:0001427)2.03465806
78Aplasia cutis congenita (HP:0001057)2.02907558
79Male pseudohermaphroditism (HP:0000037)2.02376968
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01142716
81Gaze-evoked nystagmus (HP:0000640)2.00814817
82Cystic liver disease (HP:0006706)2.00534527
83Abnormal number of erythroid precursors (HP:0012131)1.98595159
84Lactic acidosis (HP:0003128)1.98481923
85Abnormality of the renal collecting system (HP:0004742)1.98239115
86Abnormality of vitamin B metabolism (HP:0004340)1.94904767
87Abnormality of the preputium (HP:0100587)1.94502770
88Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94106782
89Homocystinuria (HP:0002156)1.93926997
90Abnormality of homocysteine metabolism (HP:0010919)1.93926997
91Hypoplasia of the fovea (HP:0007750)1.93781423
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.93781423
93Lethargy (HP:0001254)1.93282305
94Type II lissencephaly (HP:0007260)1.92172507
95Abnormality of methionine metabolism (HP:0010901)1.91484310
96Optic nerve hypoplasia (HP:0000609)1.91463089
97Hypoplasia of the uterus (HP:0000013)1.91198340
98Confusion (HP:0001289)1.90870472
99Focal motor seizures (HP:0011153)1.90116991
100Aplasia/hypoplasia of the uterus (HP:0008684)1.89654730
101Type I transferrin isoform profile (HP:0003642)1.87311154
102Respiratory failure (HP:0002878)1.87036554
103Postaxial foot polydactyly (HP:0001830)1.86218302
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86114121
105Keratoconus (HP:0000563)1.85899755
106Median cleft lip (HP:0000161)1.85289001
107Absent eyebrow (HP:0002223)1.85060743
108Adrenal hypoplasia (HP:0000835)1.84532741
109Anencephaly (HP:0002323)1.83607971
110Abnormality of renal resorption (HP:0011038)1.83333232
111Abnormality of the parietal bone (HP:0002696)1.83331347
112Aplasia/Hypoplasia of the lens (HP:0008063)1.82820162
113Chromsome breakage (HP:0040012)1.81970232
114Absent epiphyses (HP:0010577)1.81136797
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81136797
116Concave nail (HP:0001598)1.79642459
117Small epiphyses (HP:0010585)1.78318910
118Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77890503
119Volvulus (HP:0002580)1.77599113
120Intestinal atresia (HP:0011100)1.77395955
121Progressive macrocephaly (HP:0004481)1.77207708
122Tubular atrophy (HP:0000092)1.76997723
123J-shaped sella turcica (HP:0002680)1.76742057
124Submucous cleft hard palate (HP:0000176)1.76397801
125Dyschromatopsia (HP:0007641)1.76240202
126Asplenia (HP:0001746)1.76143149
127Abnormality of dental color (HP:0011073)1.75799170
128True hermaphroditism (HP:0010459)1.75767897
129Methylmalonic acidemia (HP:0002912)1.75714177
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75228149
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75228149
132Abnormality of the fovea (HP:0000493)1.75146494
133Nasolacrimal duct obstruction (HP:0000579)1.74570492
134Conical tooth (HP:0000698)1.74336870
135Molar tooth sign on MRI (HP:0002419)1.74323001
136Abnormality of midbrain morphology (HP:0002418)1.74323001
137Polydipsia (HP:0001959)1.74206855
138Abnormal drinking behavior (HP:0030082)1.74206855
139Rhinitis (HP:0012384)1.74043672
140Anhidrosis (HP:0000970)1.73777075
141Abnormality of urine glucose concentration (HP:0011016)1.73697705
142Glycosuria (HP:0003076)1.73697705
143Congenital sensorineural hearing impairment (HP:0008527)1.73073497
144Optic disc pallor (HP:0000543)1.73019670
145Meningioma (HP:0002858)1.73002929
146Abnormality of the vitamin B12 metabolism (HP:0004341)1.72987971
147Inability to walk (HP:0002540)1.72954659
148Abnormality of cells of the erythroid lineage (HP:0012130)1.72663825
149Pheochromocytoma (HP:0002666)1.72358844
150Abnormality of the nasolacrimal system (HP:0000614)1.72214839
151Preaxial hand polydactyly (HP:0001177)1.72181888
152Clubbing of toes (HP:0100760)1.71916466
153Xerostomia (HP:0000217)1.71240383
154Abnormal mitochondria in muscle tissue (HP:0008316)1.70556461
155Bifid tongue (HP:0010297)1.70389304
156Aplasia involving bones of the extremities (HP:0009825)1.70082040
157Aplasia involving bones of the upper limbs (HP:0009823)1.70082040
158Aplasia of the phalanges of the hand (HP:0009802)1.70082040
159Cerebral hypomyelination (HP:0006808)1.68561910
160Cutaneous finger syndactyly (HP:0010554)1.68135159
161Leukodystrophy (HP:0002415)1.67990933
162Poor coordination (HP:0002370)1.67488372
163Myelomeningocele (HP:0002475)1.67403310
164Abolished electroretinogram (ERG) (HP:0000550)1.64734700
165Renal agenesis (HP:0000104)1.64599128
166Short middle phalanx of the 5th finger (HP:0004220)1.64179228
167Febrile seizures (HP:0002373)1.62834244
168Widely spaced teeth (HP:0000687)1.62029803
169Exertional dyspnea (HP:0002875)1.61103002
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.60438030
171Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60219890
172Duplication of thumb phalanx (HP:0009942)1.60157324
173Increased corneal curvature (HP:0100692)1.59413505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.20558377
2VRK23.36208946
3CASK3.35960934
4STK393.05231693
5MST42.72553600
6MAPKAPK52.58776234
7MAP4K22.51479527
8CCNB12.46782662
9GRK12.43700087
10NUAK12.18363163
11MKNK12.13283790
12PBK2.05130668
13OXSR12.04169137
14BCR2.03865195
15STK161.98966496
16BRSK21.94176557
17TNIK1.86295243
18BUB11.84208815
19SIK31.73937453
20BMPR1B1.73587015
21MAP2K71.72855581
22NEK61.70552379
23WNK31.68877118
24PKN11.66684296
25FGFR21.66009227
26UHMK11.62760581
27PINK11.62292768
28PLK21.58695991
29TAOK31.58356824
30MAPK131.57557434
31TAF11.52310357
32ZAK1.51471799
33ACVR1B1.48119501
34TLK11.44155729
35VRK11.38000816
36INSRR1.35920042
37PLK41.28900386
38EIF2AK21.28124456
39BCKDK1.20720575
40STK38L1.18676165
41MAP3K121.18376303
42CDC71.16957352
43PNCK1.16911046
44TRIM281.14432756
45NEK21.13283769
46SRPK11.06213214
47MAP3K41.06108298
48IRAK11.05928076
49WNK11.05700948
50LIMK11.05644874
51PIK3CA1.05411525
52RPS6KA51.04211936
53CLK11.02628573
54BMPR20.99480535
55YES10.98908080
56ADRBK20.98542261
57TXK0.96159342
58TEC0.95934833
59ROCK20.95466640
60MKNK20.91776115
61PLK30.91262629
62DYRK20.91200087
63MAPKAPK30.89772994
64CSNK1G30.86100142
65PHKG10.86093723
66PHKG20.86093723
67BLK0.84499397
68CDK80.82253502
69EIF2AK10.79226409
70CDK190.78401299
71PRPF4B0.76763437
72IRAK20.74621123
73MUSK0.74511925
74PAK30.74492570
75TNK20.73795100
76CDK30.73572011
77EIF2AK30.73211123
78PRKCE0.73188783
79IRAK40.71475201
80PRKCQ0.71334089
81SGK4940.70520138
82SGK2230.70520138
83NTRK20.70087723
84KIT0.68166740
85EPHB10.66558325
86MAPK150.65927600
87MELK0.65068398
88WEE10.63992660
89CSNK1A1L0.63618546
90PRKCG0.62870136
91ATR0.60274679
92ADRBK10.59989746
93WNK40.59189504
94NTRK30.58305145
95NLK0.57723178
96TSSK60.56286368
97FGR0.56267660
98NEK10.56227471
99PTK2B0.55530272
100CAMK2A0.54852612
101CSNK1G20.52983443
102FES0.52784423
103CAMKK20.52354082
104DAPK20.51918711
105TRPM70.50948400
106DMPK0.50558805
107PRKG10.49345577
108CDK140.48722630
109BRSK10.47846226
110ERBB40.47275462
111CSNK1G10.47013239
112CDK180.46605213
113AURKB0.45399329
114CAMK2B0.45116494
115TTK0.44970509
116MARK10.44312956
117ABL20.44248244
118CHEK20.43013243
119NME10.42994975
120CSNK1A10.42880444
121ATM0.42432646
122STK30.42235963
123RIPK40.41972800
124TIE10.41845788
125PIM20.41496955
126AURKA0.41256379
127CSNK2A10.40590284
128CDK150.40278433
129ERBB30.37760115
130CSNK2A20.37296245
131IKBKB0.36403838
132PRKCI0.36048720
133DDR20.35952858
134CAMK2D0.35594836
135GRK70.35144404
136CDK11A0.34992964
137RPS6KB20.34869024
138PLK10.34122884
139CSNK1D0.33775117
140RPS6KB10.33239185
141ROCK10.32589439
142MINK10.32487068
143GRK50.30453785
144PRKACA0.29607146
145STK40.28534803
146CSNK1E0.27544460

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.80240562
2Steroid biosynthesis_Homo sapiens_hsa001003.17842237
3Oxidative phosphorylation_Homo sapiens_hsa001902.43408358
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.29128431
5RNA polymerase_Homo sapiens_hsa030202.16974457
6Protein export_Homo sapiens_hsa030602.08895145
7Phototransduction_Homo sapiens_hsa047442.05496242
8Sphingolipid metabolism_Homo sapiens_hsa006002.01036975
9Fatty acid elongation_Homo sapiens_hsa000621.95093699
10Ribosome_Homo sapiens_hsa030101.86766552
11Parkinsons disease_Homo sapiens_hsa050121.85472907
12Proteasome_Homo sapiens_hsa030501.80985448
13Nicotine addiction_Homo sapiens_hsa050331.78664108
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74744100
15Ether lipid metabolism_Homo sapiens_hsa005651.74350954
16Sulfur metabolism_Homo sapiens_hsa009201.72831137
17Basal transcription factors_Homo sapiens_hsa030221.71463761
18Homologous recombination_Homo sapiens_hsa034401.69024320
19Serotonergic synapse_Homo sapiens_hsa047261.68655298
20One carbon pool by folate_Homo sapiens_hsa006701.66095243
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63974307
22Nitrogen metabolism_Homo sapiens_hsa009101.60768450
23Alzheimers disease_Homo sapiens_hsa050101.59567804
24Huntingtons disease_Homo sapiens_hsa050161.54486504
25Non-homologous end-joining_Homo sapiens_hsa034501.53881628
26Fanconi anemia pathway_Homo sapiens_hsa034601.46410091
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41039931
28Propanoate metabolism_Homo sapiens_hsa006401.38112867
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37369770
30Tryptophan metabolism_Homo sapiens_hsa003801.37029988
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36811518
32Butanoate metabolism_Homo sapiens_hsa006501.35486258
33Axon guidance_Homo sapiens_hsa043601.32036423
34Selenocompound metabolism_Homo sapiens_hsa004501.27415328
35Collecting duct acid secretion_Homo sapiens_hsa049661.22719364
36Spliceosome_Homo sapiens_hsa030401.20048088
37Mismatch repair_Homo sapiens_hsa034301.19630866
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19487551
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18720571
40DNA replication_Homo sapiens_hsa030301.18595217
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18543315
42Morphine addiction_Homo sapiens_hsa050321.06943574
43Alcoholism_Homo sapiens_hsa050341.05415829
44Chemical carcinogenesis_Homo sapiens_hsa052041.02571158
45Glutamatergic synapse_Homo sapiens_hsa047241.01983286
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01471285
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00964650
48Peroxisome_Homo sapiens_hsa041460.99922983
49Nucleotide excision repair_Homo sapiens_hsa034200.99771742
50Caffeine metabolism_Homo sapiens_hsa002320.97965051
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97672416
52Arachidonic acid metabolism_Homo sapiens_hsa005900.96873070
53Long-term depression_Homo sapiens_hsa047300.96032066
54Pyrimidine metabolism_Homo sapiens_hsa002400.95127026
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94979808
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94941346
57Rheumatoid arthritis_Homo sapiens_hsa053230.94434910
58Regulation of autophagy_Homo sapiens_hsa041400.93253279
59Cell cycle_Homo sapiens_hsa041100.93142706
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92790355
61Olfactory transduction_Homo sapiens_hsa047400.92619156
62Taste transduction_Homo sapiens_hsa047420.92558888
63Autoimmune thyroid disease_Homo sapiens_hsa053200.91737850
64Folate biosynthesis_Homo sapiens_hsa007900.91526326
65Systemic lupus erythematosus_Homo sapiens_hsa053220.90855362
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90448373
67GABAergic synapse_Homo sapiens_hsa047270.90271631
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.90040977
69Vibrio cholerae infection_Homo sapiens_hsa051100.87703840
70Purine metabolism_Homo sapiens_hsa002300.87580228
71Synaptic vesicle cycle_Homo sapiens_hsa047210.87474358
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87080193
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86871287
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85077766
75Retinol metabolism_Homo sapiens_hsa008300.84197237
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83198149
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82363149
78Circadian entrainment_Homo sapiens_hsa047130.79670846
79RNA degradation_Homo sapiens_hsa030180.79281145
80Cholinergic synapse_Homo sapiens_hsa047250.74336275
81Metabolic pathways_Homo sapiens_hsa011000.73885154
82Cocaine addiction_Homo sapiens_hsa050300.72263521
83Phagosome_Homo sapiens_hsa041450.72197956
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71140282
85Linoleic acid metabolism_Homo sapiens_hsa005910.71039747
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71022852
87Dopaminergic synapse_Homo sapiens_hsa047280.69230853
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68305384
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67680451
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.64407315
91Amphetamine addiction_Homo sapiens_hsa050310.60854606
92Allograft rejection_Homo sapiens_hsa053300.60578760
93Ovarian steroidogenesis_Homo sapiens_hsa049130.59607969
94Vitamin digestion and absorption_Homo sapiens_hsa049770.59083601
95Glutathione metabolism_Homo sapiens_hsa004800.57389098
96Cardiac muscle contraction_Homo sapiens_hsa042600.57297716
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57176918
98Circadian rhythm_Homo sapiens_hsa047100.56914063
99Hedgehog signaling pathway_Homo sapiens_hsa043400.56698715
100Calcium signaling pathway_Homo sapiens_hsa040200.56151078
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55687768
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.54795443
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54514481
104Base excision repair_Homo sapiens_hsa034100.53934121
105Melanoma_Homo sapiens_hsa052180.52911944
106Hematopoietic cell lineage_Homo sapiens_hsa046400.51428839
107ErbB signaling pathway_Homo sapiens_hsa040120.51259484
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51041332
109Primary immunodeficiency_Homo sapiens_hsa053400.51016630
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.47582358
111mRNA surveillance pathway_Homo sapiens_hsa030150.47343321
112Ras signaling pathway_Homo sapiens_hsa040140.46873338
113Epstein-Barr virus infection_Homo sapiens_hsa051690.46463335
114Wnt signaling pathway_Homo sapiens_hsa043100.45398605
115beta-Alanine metabolism_Homo sapiens_hsa004100.44873693
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44384368
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43880148
118Oocyte meiosis_Homo sapiens_hsa041140.43867662
119ECM-receptor interaction_Homo sapiens_hsa045120.43571951
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.42481670
121Renin secretion_Homo sapiens_hsa049240.42390326
122N-Glycan biosynthesis_Homo sapiens_hsa005100.41011546
123Type I diabetes mellitus_Homo sapiens_hsa049400.40958178
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39889127
125Pyruvate metabolism_Homo sapiens_hsa006200.38716442
126Malaria_Homo sapiens_hsa051440.38656325
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38602613
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36990790
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.36858812
130RNA transport_Homo sapiens_hsa030130.36266792
131Basal cell carcinoma_Homo sapiens_hsa052170.36082250
132Graft-versus-host disease_Homo sapiens_hsa053320.35490410
133Tyrosine metabolism_Homo sapiens_hsa003500.34830719
134Insulin secretion_Homo sapiens_hsa049110.33772753
135Glycerolipid metabolism_Homo sapiens_hsa005610.33510678
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.32549579
137Notch signaling pathway_Homo sapiens_hsa043300.32159328
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31040057
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30810632
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29793599
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27990157
142Asthma_Homo sapiens_hsa053100.26898276
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26889599
144MAPK signaling pathway_Homo sapiens_hsa040100.26845356
145p53 signaling pathway_Homo sapiens_hsa041150.26376043
146Sulfur relay system_Homo sapiens_hsa041220.26283544
147Long-term potentiation_Homo sapiens_hsa047200.26145025

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