

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | response to pheromone (GO:0019236) | 4.25590004 |
| 2 | single strand break repair (GO:0000012) | 4.19944045 |
| 3 | mRNA splice site selection (GO:0006376) | 3.86745947 |
| 4 | establishment of protein localization to Golgi (GO:0072600) | 3.84387120 |
| 5 | regulation of centriole replication (GO:0046599) | 3.77370540 |
| 6 | sperm motility (GO:0030317) | 3.71553972 |
| 7 | acrosome reaction (GO:0007340) | 3.63063353 |
| 8 | protein targeting to Golgi (GO:0000042) | 3.62566574 |
| 9 | spermatid nucleus differentiation (GO:0007289) | 3.52245054 |
| 10 | microtubule polymerization or depolymerization (GO:0031109) | 3.50797226 |
| 11 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.46708085 |
| 12 | poly(A)+ mRNA export from nucleus (GO:0016973) | 3.39604249 |
| 13 | neural tube formation (GO:0001841) | 3.38750151 |
| 14 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 3.35346888 |
| 15 | epithelial cilium movement (GO:0003351) | 3.30250420 |
| 16 | limb bud formation (GO:0060174) | 3.27179330 |
| 17 | rRNA methylation (GO:0031167) | 3.24173391 |
| 18 | protein polyglutamylation (GO:0018095) | 3.23805035 |
| 19 | regulation of cilium movement (GO:0003352) | 3.22267397 |
| 20 | histone H3-K4 trimethylation (GO:0080182) | 3.19779586 |
| 21 | nonmotile primary cilium assembly (GO:0035058) | 3.13161716 |
| 22 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 3.03284042 |
| 23 | regulation of helicase activity (GO:0051095) | 3.02998943 |
| 24 | chromosome condensation (GO:0030261) | 2.97552442 |
| 25 | DNA packaging (GO:0006323) | 2.96988163 |
| 26 | regulation of mRNA splicing, via spliceosome (GO:0048024) | 2.96920358 |
| 27 | regulation of alternative mRNA splicing, via spliceosome (GO:0000381) | 2.96918869 |
| 28 | spermatid development (GO:0007286) | 2.96185589 |
| 29 | kidney morphogenesis (GO:0060993) | 2.93664577 |
| 30 | viral mRNA export from host cell nucleus (GO:0046784) | 2.92196384 |
| 31 | protein localization to Golgi apparatus (GO:0034067) | 2.91573245 |
| 32 | rRNA catabolic process (GO:0016075) | 2.90906862 |
| 33 | regulation of meiosis I (GO:0060631) | 2.89306988 |
| 34 | histone H3-K9 modification (GO:0061647) | 2.88744488 |
| 35 | peptidyl-lysine trimethylation (GO:0018023) | 2.88239877 |
| 36 | rhodopsin mediated signaling pathway (GO:0016056) | 2.86483787 |
| 37 | microtubule anchoring (GO:0034453) | 2.85649092 |
| 38 | behavioral response to nicotine (GO:0035095) | 2.82974690 |
| 39 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.80774215 |
| 40 | cilium movement (GO:0003341) | 2.79311239 |
| 41 | regulation of centrosome duplication (GO:0010824) | 2.78533959 |
| 42 | replication fork processing (GO:0031297) | 2.77897654 |
| 43 | rRNA modification (GO:0000154) | 2.77697888 |
| 44 | axonemal dynein complex assembly (GO:0070286) | 2.76474377 |
| 45 | protein K11-linked deubiquitination (GO:0035871) | 2.75470681 |
| 46 | regulation of centrosome cycle (GO:0046605) | 2.73250774 |
| 47 | DNA ligation (GO:0006266) | 2.72521775 |
| 48 | mitotic sister chromatid cohesion (GO:0007064) | 2.72234132 |
| 49 | photoreceptor cell maintenance (GO:0045494) | 2.70469001 |
| 50 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.69643605 |
| 51 | regulation of development, heterochronic (GO:0040034) | 2.69119040 |
| 52 | intraciliary transport (GO:0042073) | 2.68372161 |
| 53 | photoreceptor cell differentiation (GO:0046530) | 2.65458437 |
| 54 | eye photoreceptor cell differentiation (GO:0001754) | 2.65458437 |
| 55 | negative regulation of histone methylation (GO:0031061) | 2.64746821 |
| 56 | eye photoreceptor cell development (GO:0042462) | 2.63857478 |
| 57 | ncRNA catabolic process (GO:0034661) | 2.63287584 |
| 58 | recombinational repair (GO:0000725) | 2.62994843 |
| 59 | double-strand break repair via homologous recombination (GO:0000724) | 2.61304356 |
| 60 | regulation of timing of cell differentiation (GO:0048505) | 2.60300585 |
| 61 | regulation of mRNA processing (GO:0050684) | 2.60162273 |
| 62 | protein K6-linked ubiquitination (GO:0085020) | 2.60084193 |
| 63 | spinal cord motor neuron differentiation (GO:0021522) | 2.59967907 |
| 64 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.59816747 |
| 65 | microtubule depolymerization (GO:0007019) | 2.59578961 |
| 66 | resolution of meiotic recombination intermediates (GO:0000712) | 2.58755071 |
| 67 | centriole replication (GO:0007099) | 2.58408842 |
| 68 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.57933798 |
| 69 | peptidyl-lysine methylation (GO:0018022) | 2.56626683 |
| 70 | photoreceptor cell development (GO:0042461) | 2.56323855 |
| 71 | retina layer formation (GO:0010842) | 2.55878235 |
| 72 | microtubule organizing center organization (GO:0031023) | 2.55670740 |
| 73 | termination of RNA polymerase I transcription (GO:0006363) | 2.55555212 |
| 74 | kinetochore assembly (GO:0051382) | 2.52752938 |
| 75 | male meiosis I (GO:0007141) | 2.51531867 |
| 76 | 7-methylguanosine RNA capping (GO:0009452) | 2.50809633 |
| 77 | RNA capping (GO:0036260) | 2.50809633 |
| 78 | retinal cone cell development (GO:0046549) | 2.50052137 |
| 79 | centrosome organization (GO:0051297) | 2.49783282 |
| 80 | regulation of DNA endoreduplication (GO:0032875) | 2.48783263 |
| 81 | kinetochore organization (GO:0051383) | 2.47975456 |
| 82 | positive regulation of mRNA processing (GO:0050685) | 2.46904574 |
| 83 | centriole assembly (GO:0098534) | 2.46754734 |
| 84 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.45006720 |
| 85 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.45006720 |
| 86 | 7-methylguanosine mRNA capping (GO:0006370) | 2.44961630 |
| 87 | hindbrain development (GO:0030902) | 2.44646660 |
| 88 | neuronal stem cell maintenance (GO:0097150) | 2.44493311 |
| 89 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.44094333 |
| 90 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.44094333 |
| 91 | RNA destabilization (GO:0050779) | 2.42451896 |
| 92 | peptidyl-threonine dephosphorylation (GO:0035970) | 2.40628692 |
| 93 | presynaptic membrane assembly (GO:0097105) | 2.40434265 |
| 94 | CENP-A containing nucleosome assembly (GO:0034080) | 2.40325925 |
| 95 | mRNA export from nucleus (GO:0006406) | 2.39161052 |
| 96 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.39013886 |
| 97 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.38960349 |
| 98 | nuclear pore complex assembly (GO:0051292) | 2.38435492 |
| 99 | histone H2B ubiquitination (GO:0033523) | 2.37740497 |
| 100 | meiotic chromosome segregation (GO:0045132) | 2.37530138 |
| 101 | seminiferous tubule development (GO:0072520) | 2.37175134 |
| 102 | DNA topological change (GO:0006265) | 2.35927790 |
| 103 | cell proliferation in forebrain (GO:0021846) | 2.35191274 |
| 104 | multicellular organism reproduction (GO:0032504) | 2.35033878 |
| 105 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.34784528 |
| 106 | DNA integration (GO:0015074) | 2.34424905 |
| 107 | histone H2A acetylation (GO:0043968) | 2.33323324 |
| 108 | regulation of mRNA metabolic process (GO:1903311) | 2.33247406 |
| 109 | regulation of RNA export from nucleus (GO:0046831) | 2.32191455 |
| 110 | regulation of histone H3-K9 methylation (GO:0051570) | 2.31832368 |
| 111 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.31569358 |
| 112 | pyrimidine dimer repair (GO:0006290) | 2.30969380 |
| 113 | response to X-ray (GO:0010165) | 2.30763354 |
| 114 | RNA export from nucleus (GO:0006405) | 2.30417449 |
| 115 | chromatin remodeling at centromere (GO:0031055) | 2.30235455 |
| 116 | somite development (GO:0061053) | 2.30180315 |
| 117 | regulation of RNA splicing (GO:0043484) | 2.29867229 |
| 118 | translational termination (GO:0006415) | 2.29083625 |
| 119 | microtubule nucleation (GO:0007020) | 2.28633144 |
| 120 | regulation of telomere maintenance (GO:0032204) | 2.27411781 |
| 121 | sister chromatid cohesion (GO:0007062) | 2.23889023 |
| 122 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.22089465 |
| 123 | sympathetic nervous system development (GO:0048485) | 2.21730050 |
| 124 | mismatch repair (GO:0006298) | 2.21413373 |
| 125 | spliceosomal complex assembly (GO:0000245) | 2.21363091 |
| 126 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.20718901 |
| 127 | DNA replication-independent nucleosome organization (GO:0034724) | 2.20542072 |
| 128 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.20542072 |
| 129 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.20351391 |
| 130 | detection of light stimulus involved in visual perception (GO:0050908) | 2.20351391 |
| 131 | dentate gyrus development (GO:0021542) | 2.20162504 |
| 132 | interkinetic nuclear migration (GO:0022027) | 2.20096548 |
| 133 | positive regulation of histone methylation (GO:0031062) | 2.19188546 |
| 134 | cell differentiation involved in metanephros development (GO:0072202) | 2.18701860 |
| 135 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.18338589 |
| 136 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.18338589 |
| 137 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.18338589 |
| 138 | negative regulation of mRNA processing (GO:0050686) | 2.16903483 |
| 139 | neuron fate determination (GO:0048664) | 2.16709602 |
| 140 | otic vesicle formation (GO:0030916) | 2.16270897 |
| 141 | histone H3-K9 methylation (GO:0051567) | 2.15538601 |
| 142 | histone H3-K4 methylation (GO:0051568) | 2.15334962 |
| 143 | inner ear receptor cell differentiation (GO:0060113) | 2.15144373 |
| 144 | female gonad development (GO:0008585) | 2.15033404 |
| 145 | nuclear pore organization (GO:0006999) | 2.14943195 |
| 146 | mesenchymal cell differentiation involved in kidney development (GO:0072161) | 2.14629886 |
| 147 | mesenchymal cell differentiation involved in renal system development (GO:2001012) | 2.14629886 |
| 148 | RNA splicing, via transesterification reactions (GO:0000375) | 2.14400583 |
| 149 | regulation of gene expression by genetic imprinting (GO:0006349) | 2.14084536 |
| 150 | metaphase plate congression (GO:0051310) | 2.13929157 |
| 151 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.13778442 |
| 152 | DNA damage response, detection of DNA damage (GO:0042769) | 2.12870104 |
| 153 | positive regulation of mRNA metabolic process (GO:1903313) | 2.12671503 |
| 154 | protein localization to microtubule cytoskeleton (GO:0072698) | 2.10842996 |
| 155 | mRNA splicing, via spliceosome (GO:0000398) | 2.10651775 |
| 156 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.10651775 |
| 157 | cilium assembly (GO:0042384) | 2.10337080 |
| 158 | lateral sprouting from an epithelium (GO:0060601) | 2.09809502 |
| 159 | histone exchange (GO:0043486) | 2.08815163 |
| 160 | cilium organization (GO:0044782) | 2.08585875 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.82091780 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.80810928 |
| 3 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.15072091 |
| 4 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.92471596 |
| 5 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.87310172 |
| 6 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.58561595 |
| 7 | FUS_26573619_Chip-Seq_HEK293_Human | 2.41387079 |
| 8 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.39753035 |
| 9 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.29184488 |
| 10 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.28308016 |
| 11 | EWS_26573619_Chip-Seq_HEK293_Human | 2.25420379 |
| 12 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.24852732 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.20102807 |
| 14 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.20102477 |
| 15 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.13281477 |
| 16 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.11068201 |
| 17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.03861677 |
| 18 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.03765801 |
| 19 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.01061407 |
| 20 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.98118248 |
| 21 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.97858719 |
| 22 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.85852676 |
| 23 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.78899563 |
| 24 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.77690042 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.73276892 |
| 26 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.68916846 |
| 27 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.68916846 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.67184927 |
| 29 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.65710590 |
| 30 | P300_19829295_ChIP-Seq_ESCs_Human | 1.62017444 |
| 31 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.61710525 |
| 32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.61693765 |
| 33 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.61599731 |
| 34 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.60306923 |
| 35 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.57624467 |
| 36 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.56963575 |
| 37 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.56726344 |
| 38 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.54236983 |
| 39 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.49296806 |
| 40 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.48413401 |
| 41 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.46208958 |
| 42 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.45412846 |
| 43 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.45116396 |
| 44 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.43768430 |
| 45 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.43234993 |
| 46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.43059594 |
| 47 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.41736765 |
| 48 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.41307475 |
| 49 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.39466543 |
| 50 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.38638764 |
| 51 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.38609798 |
| 52 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.38154549 |
| 53 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.35730348 |
| 54 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.35490853 |
| 55 | STAT3_23295773_ChIP-Seq_U87_Human | 1.35395475 |
| 56 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.34598827 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.34315201 |
| 58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.34171454 |
| 59 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.33817375 |
| 60 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.33090564 |
| 61 | AR_25329375_ChIP-Seq_VCAP_Human | 1.32517041 |
| 62 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.31894734 |
| 63 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.30346446 |
| 64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.30294409 |
| 65 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.29327888 |
| 66 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.29189737 |
| 67 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.29176486 |
| 68 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.28244372 |
| 69 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.27939052 |
| 70 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.27620789 |
| 71 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.27018887 |
| 72 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.26695818 |
| 73 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.25910736 |
| 74 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.24426926 |
| 75 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.23491552 |
| 76 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.22524318 |
| 77 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.22275697 |
| 78 | TCF4_23295773_ChIP-Seq_U87_Human | 1.21271396 |
| 79 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.20986627 |
| 80 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.20692831 |
| 81 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.20433800 |
| 82 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.19348317 |
| 83 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.19245935 |
| 84 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.18176897 |
| 85 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.17924535 |
| 86 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.17561639 |
| 87 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.16721160 |
| 88 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.15842649 |
| 89 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.15439507 |
| 90 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.12936506 |
| 91 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.12199927 |
| 92 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.11404201 |
| 93 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11336873 |
| 94 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.11194090 |
| 95 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.10215792 |
| 96 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.09207991 |
| 97 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.09042940 |
| 98 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.08138910 |
| 99 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.07917979 |
| 100 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07889960 |
| 101 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.07328728 |
| 102 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.07255285 |
| 103 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.07052908 |
| 104 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.05957232 |
| 105 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05957232 |
| 106 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05764041 |
| 107 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 1.04641903 |
| 108 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.04359373 |
| 109 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.04116898 |
| 110 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03922961 |
| 111 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.03491483 |
| 112 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.03491483 |
| 113 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.03131922 |
| 114 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.03097624 |
| 115 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.00843982 |
| 116 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.00795640 |
| 117 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.00537096 |
| 118 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.00291419 |
| 119 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.00223128 |
| 120 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.99905171 |
| 121 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.99227554 |
| 122 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99010001 |
| 123 | TBL1_22424771_ChIP-Seq_293T_Human | 0.98712795 |
| 124 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.97830622 |
| 125 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.97124282 |
| 126 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.96877345 |
| 127 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.96855772 |
| 128 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96687837 |
| 129 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.96386002 |
| 130 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.95752312 |
| 131 | NFYB_21822215_ChIP-Seq_K562_Human | 0.95071625 |
| 132 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.94838284 |
| 133 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 0.93971520 |
| 134 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.92502974 |
| 135 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.89344545 |
| 136 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.89130168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.28136645 |
| 2 | MP0008057_abnormal_DNA_replication | 3.21637347 |
| 3 | MP0008058_abnormal_DNA_repair | 2.77010474 |
| 4 | MP0003787_abnormal_imprinting | 2.72059679 |
| 5 | MP0003136_yellow_coat_color | 2.63695374 |
| 6 | MP0005409_darkened_coat_color | 2.61522706 |
| 7 | MP0000566_synostosis | 2.52704588 |
| 8 | MP0005410_abnormal_fertilization | 2.24888180 |
| 9 | MP0010094_abnormal_chromosome_stability | 2.19802627 |
| 10 | MP0002938_white_spotting | 2.19042840 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.13217300 |
| 12 | MP0001986_abnormal_taste_sensitivity | 2.11026084 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.09913422 |
| 14 | MP0001188_hyperpigmentation | 1.97639062 |
| 15 | MP0003121_genomic_imprinting | 1.93360743 |
| 16 | MP0008007_abnormal_cellular_replicative | 1.92994944 |
| 17 | MP0005551_abnormal_eye_electrophysiolog | 1.78733809 |
| 18 | MP0001929_abnormal_gametogenesis | 1.74376994 |
| 19 | MP0000015_abnormal_ear_pigmentation | 1.74100507 |
| 20 | MP0002009_preneoplasia | 1.72222601 |
| 21 | MP0003698_abnormal_male_reproductive | 1.70959378 |
| 22 | MP0005253_abnormal_eye_physiology | 1.70915093 |
| 23 | MP0005171_absent_coat_pigmentation | 1.67552583 |
| 24 | MP0003693_abnormal_embryo_hatching | 1.61045628 |
| 25 | MP0005379_endocrine/exocrine_gland_phen | 1.59459565 |
| 26 | MP0000778_abnormal_nervous_system | 1.56630276 |
| 27 | MP0002638_abnormal_pupillary_reflex | 1.56449308 |
| 28 | MP0003878_abnormal_ear_physiology | 1.52067347 |
| 29 | MP0005377_hearing/vestibular/ear_phenot | 1.52067347 |
| 30 | MP0003077_abnormal_cell_cycle | 1.43643134 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.42855511 |
| 32 | MP0003315_abnormal_perineum_morphology | 1.41690262 |
| 33 | MP0000372_irregular_coat_pigmentation | 1.39641476 |
| 34 | MP0003941_abnormal_skin_development | 1.39121260 |
| 35 | MP0003937_abnormal_limbs/digits/tail_de | 1.37714450 |
| 36 | MP0003950_abnormal_plasma_membrane | 1.37587933 |
| 37 | MP0002277_abnormal_respiratory_mucosa | 1.36774031 |
| 38 | MP0000049_abnormal_middle_ear | 1.36109640 |
| 39 | MP0000631_abnormal_neuroendocrine_gland | 1.35640252 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.30722748 |
| 41 | MP0003718_maternal_effect | 1.30277944 |
| 42 | MP0001529_abnormal_vocalization | 1.29544716 |
| 43 | MP0001286_abnormal_eye_development | 1.28475409 |
| 44 | MP0005187_abnormal_penis_morphology | 1.27480553 |
| 45 | MP0002751_abnormal_autonomic_nervous | 1.24558812 |
| 46 | MP0004381_abnormal_hair_follicle | 1.23670691 |
| 47 | MP0010030_abnormal_orbit_morphology | 1.23589703 |
| 48 | MP0002102_abnormal_ear_morphology | 1.23466970 |
| 49 | MP0003111_abnormal_nucleus_morphology | 1.22790304 |
| 50 | MP0002234_abnormal_pharynx_morphology | 1.22183663 |
| 51 | MP0001145_abnormal_male_reproductive | 1.20291663 |
| 52 | MP0004142_abnormal_muscle_tone | 1.20197812 |
| 53 | MP0002095_abnormal_skin_pigmentation | 1.19360705 |
| 54 | MP0003786_premature_aging | 1.18691783 |
| 55 | MP0000653_abnormal_sex_gland | 1.18020887 |
| 56 | MP0004885_abnormal_endolymph | 1.17895038 |
| 57 | MP0002163_abnormal_gland_morphology | 1.17317525 |
| 58 | MP0002928_abnormal_bile_duct | 1.17078106 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.15626250 |
| 60 | MP0008995_early_reproductive_senescence | 1.14849328 |
| 61 | MP0005391_vision/eye_phenotype | 1.14396500 |
| 62 | MP0003755_abnormal_palate_morphology | 1.14031135 |
| 63 | MP0000955_abnormal_spinal_cord | 1.11444690 |
| 64 | MP0003385_abnormal_body_wall | 1.10340870 |
| 65 | MP0003890_abnormal_embryonic-extraembry | 1.10168394 |
| 66 | MP0002557_abnormal_social/conspecific_i | 1.09726079 |
| 67 | MP0002177_abnormal_outer_ear | 1.09636504 |
| 68 | MP0001486_abnormal_startle_reflex | 1.08715660 |
| 69 | MP0003938_abnormal_ear_development | 1.08380537 |
| 70 | MP0003123_paternal_imprinting | 1.07741010 |
| 71 | MP0000516_abnormal_urinary_system | 1.07404711 |
| 72 | MP0005367_renal/urinary_system_phenotyp | 1.07404711 |
| 73 | MP0003122_maternal_imprinting | 1.06468853 |
| 74 | MP0008932_abnormal_embryonic_tissue | 1.05175168 |
| 75 | MP0009250_abnormal_appendicular_skeleto | 1.05124499 |
| 76 | MP0009745_abnormal_behavioral_response | 1.04392950 |
| 77 | MP0001346_abnormal_lacrimal_gland | 1.04149538 |
| 78 | MP0008961_abnormal_basal_metabolism | 1.03951167 |
| 79 | MP0001502_abnormal_circadian_rhythm | 1.01866835 |
| 80 | MP0002233_abnormal_nose_morphology | 0.99938395 |
| 81 | MP0005499_abnormal_olfactory_system | 0.99808546 |
| 82 | MP0005394_taste/olfaction_phenotype | 0.99808546 |
| 83 | MP0002184_abnormal_innervation | 0.99657131 |
| 84 | MP0002736_abnormal_nociception_after | 0.99375274 |
| 85 | MP0003119_abnormal_digestive_system | 0.98949258 |
| 86 | MP0009046_muscle_twitch | 0.96702488 |
| 87 | MP0000026_abnormal_inner_ear | 0.95787736 |
| 88 | MP0009379_abnormal_foot_pigmentation | 0.95387192 |
| 89 | MP0005195_abnormal_posterior_eye | 0.95362840 |
| 90 | MP0003646_muscle_fatigue | 0.95316759 |
| 91 | MP0001905_abnormal_dopamine_level | 0.95154786 |
| 92 | MP0001968_abnormal_touch/_nociception | 0.94473917 |
| 93 | MP0000647_abnormal_sebaceous_gland | 0.93982768 |
| 94 | MP0001293_anophthalmia | 0.91826111 |
| 95 | MP0004742_abnormal_vestibular_system | 0.91686793 |
| 96 | MP0002735_abnormal_chemical_nociception | 0.90191760 |
| 97 | MP0002210_abnormal_sex_determination | 0.90163272 |
| 98 | MP0002161_abnormal_fertility/fecundity | 0.90051787 |
| 99 | MP0002116_abnormal_craniofacial_bone | 0.89338401 |
| 100 | MP0001984_abnormal_olfaction | 0.88400735 |
| 101 | MP0004147_increased_porphyrin_level | 0.87951994 |
| 102 | MP0004957_abnormal_blastocyst_morpholog | 0.87133652 |
| 103 | MP0005248_abnormal_Harderian_gland | 0.87077309 |
| 104 | MP0003861_abnormal_nervous_system | 0.84649903 |
| 105 | MP0003935_abnormal_craniofacial_develop | 0.83817181 |
| 106 | MP0002067_abnormal_sensory_capabilities | 0.83598926 |
| 107 | MP0001485_abnormal_pinna_reflex | 0.83454981 |
| 108 | MP0002752_abnormal_somatic_nervous | 0.83406656 |
| 109 | MP0000383_abnormal_hair_follicle | 0.83305125 |
| 110 | MP0005423_abnormal_somatic_nervous | 0.82811882 |
| 111 | MP0002282_abnormal_trachea_morphology | 0.82775191 |
| 112 | MP0002697_abnormal_eye_size | 0.82430621 |
| 113 | MP0001963_abnormal_hearing_physiology | 0.81728481 |
| 114 | MP0002272_abnormal_nervous_system | 0.81646233 |
| 115 | MP0000537_abnormal_urethra_morphology | 0.80696763 |
| 116 | MP0002572_abnormal_emotion/affect_behav | 0.79687944 |
| 117 | MP0002152_abnormal_brain_morphology | 0.79396064 |
| 118 | MP0001186_pigmentation_phenotype | 0.79181658 |
| 119 | MP0009697_abnormal_copulation | 0.78113513 |
| 120 | MP0000427_abnormal_hair_cycle | 0.77069181 |
| 121 | MP0005389_reproductive_system_phenotype | 0.76692166 |
| 122 | MP0000432_abnormal_head_morphology | 0.75634991 |
| 123 | MP0000569_abnormal_digit_pigmentation | 0.75586075 |
| 124 | MP0004133_heterotaxia | 0.74900219 |
| 125 | MP0003763_abnormal_thymus_physiology | 0.73969415 |
| 126 | MP0001177_atelectasis | 0.73291045 |
| 127 | MP0002114_abnormal_axial_skeleton | 0.70873560 |
| 128 | MP0003880_abnormal_central_pattern | 0.70321853 |
| 129 | MP0000428_abnormal_craniofacial_morphol | 0.70184949 |
| 130 | MP0000613_abnormal_salivary_gland | 0.69579472 |
| 131 | MP0004134_abnormal_chest_morphology | 0.69315928 |
| 132 | MP0001299_abnormal_eye_distance/ | 0.68975632 |
| 133 | MP0006276_abnormal_autonomic_nervous | 0.68526932 |
| 134 | MP0001324_abnormal_eye_pigmentation | 0.68461011 |
| 135 | MP0002653_abnormal_ependyma_morphology | 0.67997738 |
| 136 | MP0001340_abnormal_eyelid_morphology | 0.66253374 |
| 137 | MP0003567_abnormal_fetal_cardiomyocyte | 0.66061308 |
| 138 | MP0002160_abnormal_reproductive_system | 0.65864064 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Congenital stationary night blindness (HP:0007642) | 3.40226603 |
| 2 | Abnormal hair whorl (HP:0010721) | 2.98795702 |
| 3 | True hermaphroditism (HP:0010459) | 2.93089017 |
| 4 | Abnormality of incisor morphology (HP:0011063) | 2.82969038 |
| 5 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.74785396 |
| 6 | Chromsome breakage (HP:0040012) | 2.71093000 |
| 7 | Septo-optic dysplasia (HP:0100842) | 2.69756836 |
| 8 | Pancreatic fibrosis (HP:0100732) | 2.69247319 |
| 9 | Volvulus (HP:0002580) | 2.61331890 |
| 10 | Intestinal atresia (HP:0011100) | 2.45131516 |
| 11 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.42683930 |
| 12 | Hypoplasia of the fovea (HP:0007750) | 2.42683930 |
| 13 | Pancreatic cysts (HP:0001737) | 2.36128571 |
| 14 | Abnormality of the renal cortex (HP:0011035) | 2.30897485 |
| 15 | Cerebellar dysplasia (HP:0007033) | 2.27617784 |
| 16 | Sclerocornea (HP:0000647) | 2.26883968 |
| 17 | Molar tooth sign on MRI (HP:0002419) | 2.26860537 |
| 18 | Abnormality of midbrain morphology (HP:0002418) | 2.26860537 |
| 19 | Cystic liver disease (HP:0006706) | 2.24207202 |
| 20 | Progressive cerebellar ataxia (HP:0002073) | 2.24040005 |
| 21 | Hypothermia (HP:0002045) | 2.23774031 |
| 22 | Medial flaring of the eyebrow (HP:0010747) | 2.23467746 |
| 23 | Abnormality of the incisor (HP:0000676) | 2.23243269 |
| 24 | Papillary thyroid carcinoma (HP:0002895) | 2.23038058 |
| 25 | Absent/shortened dynein arms (HP:0200106) | 2.21171055 |
| 26 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.21171055 |
| 27 | Attenuation of retinal blood vessels (HP:0007843) | 2.20400735 |
| 28 | Oligodactyly (hands) (HP:0001180) | 2.19404352 |
| 29 | Type II lissencephaly (HP:0007260) | 2.18453090 |
| 30 | Preaxial hand polydactyly (HP:0001177) | 2.16962929 |
| 31 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.16899782 |
| 32 | Birth length less than 3rd percentile (HP:0003561) | 2.14363649 |
| 33 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.13764493 |
| 34 | Reticulocytopenia (HP:0001896) | 2.13428842 |
| 35 | Ectopic kidney (HP:0000086) | 2.12448772 |
| 36 | Sloping forehead (HP:0000340) | 2.12248355 |
| 37 | Abnormality of the columella (HP:0009929) | 2.10857021 |
| 38 | Abnormality of the fovea (HP:0000493) | 2.09228510 |
| 39 | Impulsivity (HP:0100710) | 2.07621591 |
| 40 | Optic nerve hypoplasia (HP:0000609) | 2.06877419 |
| 41 | Nephrogenic diabetes insipidus (HP:0009806) | 2.05451484 |
| 42 | Genetic anticipation (HP:0003743) | 2.04078142 |
| 43 | Nephronophthisis (HP:0000090) | 2.03922443 |
| 44 | Abnormality of the renal collecting system (HP:0004742) | 2.03152099 |
| 45 | Congenital primary aphakia (HP:0007707) | 2.01631886 |
| 46 | Cupped ear (HP:0000378) | 2.01597647 |
| 47 | Abnormality of the pons (HP:0007361) | 1.99533623 |
| 48 | Duplicated collecting system (HP:0000081) | 1.99332896 |
| 49 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.99125233 |
| 50 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.97671425 |
| 51 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.96819077 |
| 52 | Male pseudohermaphroditism (HP:0000037) | 1.96392709 |
| 53 | Absent septum pellucidum (HP:0001331) | 1.96357794 |
| 54 | Hypoplastic ischia (HP:0003175) | 1.96042664 |
| 55 | Tubulointerstitial nephritis (HP:0001970) | 1.95407868 |
| 56 | Abnormality of the septum pellucidum (HP:0007375) | 1.94973000 |
| 57 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.94059828 |
| 58 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.94059828 |
| 59 | Hyperventilation (HP:0002883) | 1.92314628 |
| 60 | Abnormality of the nasal septum (HP:0000419) | 1.92004048 |
| 61 | White forelock (HP:0002211) | 1.91575970 |
| 62 | Esophageal atresia (HP:0002032) | 1.91546178 |
| 63 | Gait imbalance (HP:0002141) | 1.91516467 |
| 64 | Abnormality of the ischium (HP:0003174) | 1.91432822 |
| 65 | Supernumerary spleens (HP:0009799) | 1.89916758 |
| 66 | Medulloblastoma (HP:0002885) | 1.89683239 |
| 67 | Chronic hepatic failure (HP:0100626) | 1.89403159 |
| 68 | Occipital encephalocele (HP:0002085) | 1.88169441 |
| 69 | Triphalangeal thumb (HP:0001199) | 1.88019681 |
| 70 | Abnormality of the renal medulla (HP:0100957) | 1.85931965 |
| 71 | Abnormal lung lobation (HP:0002101) | 1.84974597 |
| 72 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.84812689 |
| 73 | Patchy hypopigmentation of hair (HP:0011365) | 1.84469484 |
| 74 | Severe visual impairment (HP:0001141) | 1.83943482 |
| 75 | Dandy-Walker malformation (HP:0001305) | 1.83236344 |
| 76 | Growth hormone deficiency (HP:0000824) | 1.82986856 |
| 77 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.82770447 |
| 78 | Highly arched eyebrow (HP:0002553) | 1.82485605 |
| 79 | Colon cancer (HP:0003003) | 1.82299743 |
| 80 | Hypoplasia of the pons (HP:0012110) | 1.81696338 |
| 81 | Vitreoretinal degeneration (HP:0000655) | 1.81470468 |
| 82 | Embryonal renal neoplasm (HP:0011794) | 1.80577711 |
| 83 | Genital tract atresia (HP:0001827) | 1.79995410 |
| 84 | Lissencephaly (HP:0001339) | 1.79985702 |
| 85 | Tubular atrophy (HP:0000092) | 1.79476697 |
| 86 | Optic nerve coloboma (HP:0000588) | 1.79387528 |
| 87 | Postaxial foot polydactyly (HP:0001830) | 1.79128982 |
| 88 | Abnormal number of incisors (HP:0011064) | 1.79031185 |
| 89 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.78374046 |
| 90 | Abnormality of macular pigmentation (HP:0008002) | 1.78162971 |
| 91 | Adrenal hypoplasia (HP:0000835) | 1.77840701 |
| 92 | Postaxial hand polydactyly (HP:0001162) | 1.76356387 |
| 93 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.76214067 |
| 94 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.74376349 |
| 95 | Median cleft lip (HP:0000161) | 1.74286159 |
| 96 | Duodenal stenosis (HP:0100867) | 1.74191630 |
| 97 | Small intestinal stenosis (HP:0012848) | 1.74191630 |
| 98 | Truncal obesity (HP:0001956) | 1.73600466 |
| 99 | Sex reversal (HP:0012245) | 1.73500568 |
| 100 | Abnormal sex determination (HP:0012244) | 1.73500568 |
| 101 | Vaginal atresia (HP:0000148) | 1.72382038 |
| 102 | Anophthalmia (HP:0000528) | 1.72196250 |
| 103 | Hypoplastic iliac wings (HP:0002866) | 1.71781283 |
| 104 | Congenital hepatic fibrosis (HP:0002612) | 1.71384910 |
| 105 | Small hand (HP:0200055) | 1.71055452 |
| 106 | Anencephaly (HP:0002323) | 1.70611235 |
| 107 | Gastrointestinal atresia (HP:0002589) | 1.70407452 |
| 108 | Holoprosencephaly (HP:0001360) | 1.70311771 |
| 109 | Pendular nystagmus (HP:0012043) | 1.70259075 |
| 110 | Abnormality of the preputium (HP:0100587) | 1.70229285 |
| 111 | Small epiphyses (HP:0010585) | 1.70046894 |
| 112 | Short middle phalanx of the 5th finger (HP:0004220) | 1.69796875 |
| 113 | Abnormality of chromosome stability (HP:0003220) | 1.69786638 |
| 114 | Abnormality of DNA repair (HP:0003254) | 1.69521669 |
| 115 | Bilateral microphthalmos (HP:0007633) | 1.69521333 |
| 116 | Lip pit (HP:0100267) | 1.68150081 |
| 117 | Poor coordination (HP:0002370) | 1.68065566 |
| 118 | Clubbing of toes (HP:0100760) | 1.67451378 |
| 119 | Abnormality of the duodenum (HP:0002246) | 1.67411478 |
| 120 | Meckel diverticulum (HP:0002245) | 1.67358466 |
| 121 | Keratoconus (HP:0000563) | 1.67336911 |
| 122 | Increased corneal curvature (HP:0100692) | 1.67336911 |
| 123 | Midline defect of the nose (HP:0004122) | 1.66417731 |
| 124 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.66192655 |
| 125 | Renal dysplasia (HP:0000110) | 1.66138958 |
| 126 | Drooling (HP:0002307) | 1.65982033 |
| 127 | Broad-based gait (HP:0002136) | 1.65159970 |
| 128 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.65140988 |
| 129 | Abnormality of the nasolacrimal system (HP:0000614) | 1.63584678 |
| 130 | Astigmatism (HP:0000483) | 1.62886212 |
| 131 | Abnormality of the ileum (HP:0001549) | 1.62435022 |
| 132 | Decreased central vision (HP:0007663) | 1.62415351 |
| 133 | Protruding tongue (HP:0010808) | 1.61570697 |
| 134 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.61255150 |
| 135 | Fibular hypoplasia (HP:0003038) | 1.61093337 |
| 136 | Abnormality of the fingertips (HP:0001211) | 1.60772297 |
| 137 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.60599649 |
| 138 | Abnormal ciliary motility (HP:0012262) | 1.60323235 |
| 139 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.60288481 |
| 140 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.60286129 |
| 141 | Irregular epiphyses (HP:0010582) | 1.60285115 |
| 142 | 11 pairs of ribs (HP:0000878) | 1.59496555 |
| 143 | Anomalous pulmonary venous return (HP:0010772) | 1.59321962 |
| 144 | Patellar aplasia (HP:0006443) | 1.59280093 |
| 145 | Stomach cancer (HP:0012126) | 1.58230654 |
| 146 | Abnormality of the labia minora (HP:0012880) | 1.57413207 |
| 147 | Aganglionic megacolon (HP:0002251) | 1.55166897 |
| 148 | Abnormality of the parietal bone (HP:0002696) | 1.55064838 |
| 149 | Febrile seizures (HP:0002373) | 1.54619157 |
| 150 | Congenital sensorineural hearing impairment (HP:0008527) | 1.53601916 |
| 151 | Aplasia cutis congenita (HP:0001057) | 1.53071624 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MKNK2 | 6.21501004 |
| 2 | MKNK1 | 4.74914858 |
| 3 | TNIK | 3.87170191 |
| 4 | SRPK1 | 2.61595087 |
| 5 | CASK | 2.31656786 |
| 6 | NEK6 | 2.11772870 |
| 7 | BRD4 | 2.11355384 |
| 8 | BMPR1B | 1.78463784 |
| 9 | CAMK1G | 1.74332605 |
| 10 | MAP4K2 | 1.69351061 |
| 11 | PNCK | 1.68578800 |
| 12 | CDK3 | 1.67767599 |
| 13 | BCR | 1.58539310 |
| 14 | MAP3K4 | 1.55776425 |
| 15 | ERBB3 | 1.50123856 |
| 16 | VRK1 | 1.49314632 |
| 17 | SIK3 | 1.47078891 |
| 18 | ZAK | 1.46409552 |
| 19 | MAPK13 | 1.44751036 |
| 20 | YES1 | 1.42966263 |
| 21 | CDC7 | 1.41532619 |
| 22 | STK16 | 1.34714306 |
| 23 | PLK3 | 1.32102917 |
| 24 | TAOK3 | 1.29451056 |
| 25 | INSRR | 1.27193015 |
| 26 | PASK | 1.25874142 |
| 27 | MST4 | 1.21298038 |
| 28 | NEK2 | 1.16821641 |
| 29 | EIF2AK2 | 1.15561530 |
| 30 | MAP2K7 | 1.14944905 |
| 31 | DYRK3 | 1.13596155 |
| 32 | TXK | 1.12932888 |
| 33 | CAMK1D | 1.12242592 |
| 34 | IRAK4 | 1.10004008 |
| 35 | PLK4 | 1.07009577 |
| 36 | MAPK15 | 1.06212661 |
| 37 | SGK2 | 1.04902358 |
| 38 | WNK4 | 1.04198684 |
| 39 | MARK1 | 1.03814982 |
| 40 | PLK2 | 1.01342367 |
| 41 | AKT3 | 0.99215563 |
| 42 | EIF2AK3 | 0.97923256 |
| 43 | NTRK2 | 0.95498903 |
| 44 | CDK12 | 0.94486475 |
| 45 | BRSK2 | 0.94164085 |
| 46 | ATR | 0.94145841 |
| 47 | ACVR1B | 0.92471624 |
| 48 | CCNB1 | 0.91412160 |
| 49 | NUAK1 | 0.91299100 |
| 50 | PBK | 0.90947503 |
| 51 | PRPF4B | 0.90097403 |
| 52 | TYRO3 | 0.89892579 |
| 53 | EPHA4 | 0.89197770 |
| 54 | DYRK2 | 0.88491490 |
| 55 | PINK1 | 0.88411588 |
| 56 | WEE1 | 0.88262667 |
| 57 | TEC | 0.87277164 |
| 58 | TSSK6 | 0.86131961 |
| 59 | OXSR1 | 0.84949605 |
| 60 | CLK1 | 0.82941218 |
| 61 | SIK2 | 0.82148866 |
| 62 | DYRK1A | 0.80887876 |
| 63 | RPS6KA5 | 0.79909059 |
| 64 | GRK1 | 0.79533363 |
| 65 | CDK8 | 0.79181012 |
| 66 | ATM | 0.78848076 |
| 67 | FRK | 0.77744015 |
| 68 | MAP3K14 | 0.76527935 |
| 69 | BMPR2 | 0.76243963 |
| 70 | TAOK2 | 0.75336958 |
| 71 | CHEK2 | 0.74923554 |
| 72 | PIK3CA | 0.74034773 |
| 73 | FGFR2 | 0.73049484 |
| 74 | SGK223 | 0.72574608 |
| 75 | SGK494 | 0.72574608 |
| 76 | IRAK2 | 0.72151198 |
| 77 | IRAK3 | 0.72022901 |
| 78 | CSNK1A1L | 0.71688470 |
| 79 | STK3 | 0.70172268 |
| 80 | CDK7 | 0.67123758 |
| 81 | TGFBR1 | 0.66935889 |
| 82 | CHEK1 | 0.66489805 |
| 83 | PKN1 | 0.64751044 |
| 84 | NLK | 0.63592239 |
| 85 | GRK7 | 0.63500056 |
| 86 | TAF1 | 0.62470056 |
| 87 | DYRK1B | 0.61461295 |
| 88 | PRKCG | 0.61064013 |
| 89 | IRAK1 | 0.60368028 |
| 90 | NTRK3 | 0.58928649 |
| 91 | PAK3 | 0.58714540 |
| 92 | STK38L | 0.57908780 |
| 93 | KSR1 | 0.56785190 |
| 94 | CSNK1E | 0.56569971 |
| 95 | MAPK7 | 0.56091438 |
| 96 | MAP3K10 | 0.53872694 |
| 97 | AURKB | 0.53204968 |
| 98 | ITK | 0.53042429 |
| 99 | WNK1 | 0.52678011 |
| 100 | CDK1 | 0.51687576 |
| 101 | CSNK1G1 | 0.51651127 |
| 102 | TLK1 | 0.50618922 |
| 103 | SGK1 | 0.50579867 |
| 104 | CSNK1G3 | 0.49664378 |
| 105 | PLK1 | 0.49639048 |
| 106 | CAMK4 | 0.48742482 |
| 107 | CHUK | 0.48405077 |
| 108 | CAMK1 | 0.47964027 |
| 109 | TTK | 0.47802323 |
| 110 | GSK3B | 0.46142407 |
| 111 | RPS6KB1 | 0.45680119 |
| 112 | PRKCE | 0.45009634 |
| 113 | STK4 | 0.43531584 |
| 114 | LATS1 | 0.43307756 |
| 115 | WNK3 | 0.43068485 |
| 116 | STK39 | 0.42698133 |
| 117 | BUB1 | 0.42159542 |
| 118 | PIM1 | 0.42129812 |
| 119 | MELK | 0.42004157 |
| 120 | CDK9 | 0.41785242 |
| 121 | SGK3 | 0.41179232 |
| 122 | UHMK1 | 0.40830624 |
| 123 | HIPK2 | 0.40724236 |
| 124 | MAPK14 | 0.40285714 |
| 125 | CDK2 | 0.39897497 |
| 126 | ADRBK2 | 0.39407151 |
| 127 | FGFR1 | 0.38584815 |
| 128 | NME1 | 0.38171743 |
| 129 | CSNK2A1 | 0.37456633 |
| 130 | RPS6KA4 | 0.37403567 |
| 131 | MARK3 | 0.36461108 |
| 132 | PRKDC | 0.35338833 |
| 133 | PRKG1 | 0.35219668 |
| 134 | CSNK2A2 | 0.34383418 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phototransduction_Homo sapiens_hsa04744 | 3.08954240 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.85833785 |
| 3 | Basal transcription factors_Homo sapiens_hsa03022 | 2.68372990 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 2.66899283 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.44483983 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 2.32537063 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.32468116 |
| 8 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.30460553 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.19531466 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.07050898 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.93028717 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 1.90638521 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.79939082 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 1.73696115 |
| 15 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.72092932 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 1.68581937 |
| 17 | DNA replication_Homo sapiens_hsa03030 | 1.58373245 |
| 18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.55311589 |
| 19 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.53927872 |
| 20 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.51742243 |
| 21 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.50674084 |
| 22 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.47717053 |
| 23 | Olfactory transduction_Homo sapiens_hsa04740 | 1.46271482 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.42046923 |
| 25 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.37135844 |
| 26 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.30815494 |
| 27 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.29668990 |
| 28 | Ribosome_Homo sapiens_hsa03010 | 1.27987511 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.27677403 |
| 30 | Parkinsons disease_Homo sapiens_hsa05012 | 1.26864567 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.18194996 |
| 32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.15997990 |
| 33 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.12721567 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.11601670 |
| 35 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.09201102 |
| 36 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.06250252 |
| 37 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.05037846 |
| 38 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.03647066 |
| 39 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.03083975 |
| 40 | Proteasome_Homo sapiens_hsa03050 | 1.01975826 |
| 41 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.00042000 |
| 42 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.97979606 |
| 43 | Circadian rhythm_Homo sapiens_hsa04710 | 0.97502668 |
| 44 | Lysine degradation_Homo sapiens_hsa00310 | 0.97487641 |
| 45 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.97279404 |
| 46 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.95660263 |
| 47 | Purine metabolism_Homo sapiens_hsa00230 | 0.94686127 |
| 48 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.92884342 |
| 49 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.92327804 |
| 50 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.92291750 |
| 51 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.92044317 |
| 52 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.91542401 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.91079607 |
| 54 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.90698215 |
| 55 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.90150258 |
| 56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.86679262 |
| 57 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.85956765 |
| 58 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.84212921 |
| 59 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.83979984 |
| 60 | Alcoholism_Homo sapiens_hsa05034 | 0.83499337 |
| 61 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.80274644 |
| 62 | Morphine addiction_Homo sapiens_hsa05032 | 0.80227512 |
| 63 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79979592 |
| 64 | Allograft rejection_Homo sapiens_hsa05330 | 0.79904227 |
| 65 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.78566069 |
| 66 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.77940021 |
| 67 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.76691202 |
| 68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.76392576 |
| 69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.75604317 |
| 70 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.73058765 |
| 71 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.72913177 |
| 72 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.72853101 |
| 73 | Prostate cancer_Homo sapiens_hsa05215 | 0.72628494 |
| 74 | Taste transduction_Homo sapiens_hsa04742 | 0.72129344 |
| 75 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.71462991 |
| 76 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.70769816 |
| 77 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.70653448 |
| 78 | Measles_Homo sapiens_hsa05162 | 0.70282913 |
| 79 | Axon guidance_Homo sapiens_hsa04360 | 0.67840956 |
| 80 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.66824600 |
| 81 | Nicotine addiction_Homo sapiens_hsa05033 | 0.64739828 |
| 82 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.64509994 |
| 83 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.62655403 |
| 84 | Insulin secretion_Homo sapiens_hsa04911 | 0.62136205 |
| 85 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.61886492 |
| 86 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.61560853 |
| 87 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.60375812 |
| 88 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.60119508 |
| 89 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.58015967 |
| 90 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.57722613 |
| 91 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.57641200 |
| 92 | HTLV-I infection_Homo sapiens_hsa05166 | 0.56643861 |
| 93 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.56413907 |
| 94 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.54575473 |
| 95 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.53980209 |
| 96 | Pathways in cancer_Homo sapiens_hsa05200 | 0.53022951 |
| 97 | Cocaine addiction_Homo sapiens_hsa05030 | 0.52859956 |
| 98 | Huntingtons disease_Homo sapiens_hsa05016 | 0.51849396 |
| 99 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.51552741 |
| 100 | Melanoma_Homo sapiens_hsa05218 | 0.50990217 |
| 101 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.50465585 |
| 102 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.49986971 |
| 103 | Asthma_Homo sapiens_hsa05310 | 0.49749168 |
| 104 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48994395 |
| 105 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.48725120 |
| 106 | GABAergic synapse_Homo sapiens_hsa04727 | 0.48098022 |
| 107 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.48061554 |
| 108 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.47027722 |
| 109 | ABC transporters_Homo sapiens_hsa02010 | 0.46673520 |
| 110 | Colorectal cancer_Homo sapiens_hsa05210 | 0.45437352 |
| 111 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.45278185 |
| 112 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.45015476 |
| 113 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43270161 |
| 114 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.41516541 |
| 115 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.41469011 |
| 116 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41363620 |
| 117 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.40964739 |
| 118 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.40749316 |
| 119 | Long-term depression_Homo sapiens_hsa04730 | 0.40345214 |
| 120 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.39491994 |
| 121 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.39018057 |
| 122 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.38555002 |
| 123 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.36993689 |
| 124 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.36438674 |
| 125 | Hepatitis B_Homo sapiens_hsa05161 | 0.36393491 |
| 126 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.36236318 |
| 127 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.36210260 |
| 128 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.35940261 |
| 129 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35809576 |
| 130 | Influenza A_Homo sapiens_hsa05164 | 0.35063385 |
| 131 | Circadian entrainment_Homo sapiens_hsa04713 | 0.34260631 |
| 132 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.33596392 |
| 133 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.27016023 |
| 134 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.25947633 |
| 135 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.21342389 |

