RSU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.59115776
2thrombin receptor signaling pathway (GO:0070493)6.31165078
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.47072497
4regulation of platelet aggregation (GO:0090330)5.19292719
5regulation of platelet activation (GO:0010543)4.96440808
6extracellular fibril organization (GO:0043206)4.94105749
7neutrophil activation involved in immune response (GO:0002283)4.57668731
8negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49831952
9endothelium development (GO:0003158)4.22607724
10negative regulation of platelet activation (GO:0010544)4.11496601
11platelet degranulation (GO:0002576)4.05003505
12blood coagulation, intrinsic pathway (GO:0007597)3.83504785
13regulation of homotypic cell-cell adhesion (GO:0034110)3.71410879
14positive regulation of endothelial cell differentiation (GO:0045603)3.71155535
15homotypic cell-cell adhesion (GO:0034109)3.70741751
16negative regulation of thymocyte apoptotic process (GO:0070244)3.70594990
17regulation of integrin activation (GO:0033623)3.70303209
18lipoxygenase pathway (GO:0019372)3.61249429
19adenosine receptor signaling pathway (GO:0001973)3.51821399
20positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.49824217
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.44476795
22ribosomal small subunit assembly (GO:0000028)3.43233992
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.41281522
24negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.38582160
25negative regulation of phagocytosis (GO:0050765)3.38333530
26negative regulation of stress fiber assembly (GO:0051497)3.36712934
27positive regulation of mast cell activation (GO:0033005)3.30773432
28megakaryocyte development (GO:0035855)3.27993192
29sequestering of actin monomers (GO:0042989)3.27818377
30phagocytosis, engulfment (GO:0006911)3.27364471
31G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.22259127
32positive regulation of blood coagulation (GO:0030194)3.19720916
33positive regulation of hemostasis (GO:1900048)3.19720916
34autophagic vacuole fusion (GO:0000046)3.18739856
35platelet activation (GO:0030168)3.17899827
36positive regulation of Rho protein signal transduction (GO:0035025)3.14280434
37response to interferon-alpha (GO:0035455)3.12689021
38positive regulation of receptor recycling (GO:0001921)3.10002198
39regulation of Golgi to plasma membrane protein transport (GO:0042996)3.09076513
40response to peptidoglycan (GO:0032494)3.08119235
41positive regulation of natural killer cell differentiation (GO:0032825)3.06989114
42wound healing, spreading of epidermal cells (GO:0035313)3.05803526
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05108406
44negative regulation of protein localization to plasma membrane (GO:1903077)3.02557465
45respiratory burst (GO:0045730)3.01843499
46regulation of T-helper 1 cell differentiation (GO:0045625)3.01404878
47positive regulation of macrophage differentiation (GO:0045651)2.96929062
48positive regulation of interferon-alpha production (GO:0032727)2.96751806
49fusion of sperm to egg plasma membrane (GO:0007342)2.96040556
50neutrophil activation (GO:0042119)2.93250557
51negative regulation of protein localization to cell surface (GO:2000009)2.92212686
52negative regulation of T cell apoptotic process (GO:0070233)2.91596138
53negative regulation of norepinephrine secretion (GO:0010700)2.88602389
54cyclooxygenase pathway (GO:0019371)2.88352495
55positive regulation by symbiont of host defense response (GO:0052509)2.87660168
56modulation by symbiont of host defense response (GO:0052031)2.87660168
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87660168
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87660168
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.87660168
60modulation by symbiont of host immune response (GO:0052553)2.87660168
61mesodermal cell differentiation (GO:0048333)2.87362605
62negative regulation of smooth muscle cell migration (GO:0014912)2.86741518
63definitive hemopoiesis (GO:0060216)2.86065131
64positive regulation of coagulation (GO:0050820)2.85210460
65immunoglobulin mediated immune response (GO:0016064)2.84875566
66negative regulation of heart rate (GO:0010459)2.83573286
67production of molecular mediator involved in inflammatory response (GO:0002532)2.83115036
68response to interferon-beta (GO:0035456)2.82421404
69regulation of macrophage derived foam cell differentiation (GO:0010743)2.77415542
70regulation of metalloenzyme activity (GO:0048552)2.77164123
71regulation of interferon-alpha production (GO:0032647)2.76439666
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.76153557
73positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.74994549
74negative regulation of neural precursor cell proliferation (GO:2000178)2.74982904
75regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73934438
76mitochondrial calcium ion transport (GO:0006851)2.73558829
77granulocyte activation (GO:0036230)2.73392733
78membrane raft organization (GO:0031579)2.73356547
79leukocyte degranulation (GO:0043299)2.72636692
80negative regulation of T-helper cell differentiation (GO:0045623)2.71104443
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71104443
82regulation of blood coagulation (GO:0030193)2.71040509
83regulation of hemostasis (GO:1900046)2.71040509
84platelet formation (GO:0030220)2.70109063
85actin nucleation (GO:0045010)2.69881380
86negative regulation of mast cell activation (GO:0033004)2.68967095
87wound healing, spreading of cells (GO:0044319)2.67904108
88regulation of interferon-beta biosynthetic process (GO:0045357)2.64892892
89positive regulation of lamellipodium assembly (GO:0010592)2.64395603
90purinergic nucleotide receptor signaling pathway (GO:0035590)2.63676824
91pinocytosis (GO:0006907)2.63520395
92polyamine biosynthetic process (GO:0006596)2.63408788
93intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.63181862
94regulation of receptor recycling (GO:0001919)2.60730006
95organelle membrane fusion (GO:0090174)2.60729169
96protein maturation by protein folding (GO:0022417)2.59215025
97detection of molecule of bacterial origin (GO:0032490)2.58985134
98B cell mediated immunity (GO:0019724)2.58637744
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.58402801
100membrane invagination (GO:0010324)2.57912587
101purine-containing compound salvage (GO:0043101)2.56955685
102regulation of endothelial cell differentiation (GO:0045601)2.56655964
103regulation of coagulation (GO:0050818)2.55649423
104triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53673468
105regulation of protein heterodimerization activity (GO:0043497)2.51563708
106regulation of chemokine biosynthetic process (GO:0045073)2.51391546
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50584239
108adenosine metabolic process (GO:0046085)2.49920149
109platelet aggregation (GO:0070527)2.49868676
110regulation of mast cell activation (GO:0033003)2.49657830
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.48832263
112muscle cell migration (GO:0014812)2.48618184
113fibril organization (GO:0097435)2.48095858
114hypotonic response (GO:0006971)2.46567187
115platelet dense granule organization (GO:0060155)2.46374349
116negative regulation of nitric-oxide synthase activity (GO:0051001)2.45969068
117positive regulation of B cell differentiation (GO:0045579)2.45959549
118positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.45606612
119positive regulation of interleukin-8 secretion (GO:2000484)2.45565413
120positive regulation of granulocyte differentiation (GO:0030854)2.45559445
121activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.44229249
122regulation of lipoprotein metabolic process (GO:0050746)2.44207898
123regulation of macrophage differentiation (GO:0045649)2.44028796
124G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.43246922
125pyrimidine nucleoside catabolic process (GO:0046135)2.43151568
126peptide catabolic process (GO:0043171)2.43121646
127superoxide anion generation (GO:0042554)2.42762878
128positive regulation of systemic arterial blood pressure (GO:0003084)2.41278636
129regulation of B cell receptor signaling pathway (GO:0050855)2.40354958
130regulation of integrin-mediated signaling pathway (GO:2001044)2.39310196
131chondrocyte proliferation (GO:0035988)2.37792462
132cell adhesion mediated by integrin (GO:0033627)2.37221017
133positive regulation of chemokine biosynthetic process (GO:0045080)2.36795180
134viral transcription (GO:0019083)2.36438555
135cellular extravasation (GO:0045123)2.34740305
136positive regulation of monocyte chemotaxis (GO:0090026)2.34460094
137angiogenesis involved in wound healing (GO:0060055)2.34008695
138signal peptide processing (GO:0006465)2.33635742
139regulation of necroptotic process (GO:0060544)2.32991051
140regulation of monocyte chemotaxis (GO:0090025)2.32928502
141regulation of interleukin-8 secretion (GO:2000482)2.32111445
142positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.30960288
143endosome to pigment granule transport (GO:0043485)2.30778732
144endosome to melanosome transport (GO:0035646)2.30778732
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.30442905
146endodermal cell differentiation (GO:0035987)2.30334164
147regulation of T cell migration (GO:2000404)2.29190462
148antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.28569893
149T cell apoptotic process (GO:0070231)2.28337406
150translational termination (GO:0006415)2.27969117
151regulation of mast cell activation involved in immune response (GO:0033006)2.27777935
152regulation of natural killer cell differentiation (GO:0032823)2.25720401
153myeloid cell homeostasis (GO:0002262)2.25596353
154barbed-end actin filament capping (GO:0051016)2.24831926
155regulation of mast cell degranulation (GO:0043304)2.24374204
156leukocyte aggregation (GO:0070486)2.23701168
157positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23552220
158cotranslational protein targeting to membrane (GO:0006613)2.22299167
159response to muramyl dipeptide (GO:0032495)2.22166329
160myeloid cell activation involved in immune response (GO:0002275)2.21933253
161protein targeting to ER (GO:0045047)2.21690754
162myeloid dendritic cell activation (GO:0001773)2.20556722
163cellular response to interferon-beta (GO:0035458)2.20229190
164regulation of mononuclear cell migration (GO:0071675)2.20104179
165positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.19909875
166negative regulation of myeloid cell apoptotic process (GO:0033033)2.19872282
167leukocyte migration involved in inflammatory response (GO:0002523)2.18031055
168cellular response to interferon-alpha (GO:0035457)2.18001209
169regulation of lymphocyte migration (GO:2000401)2.17971878
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.17692779
171antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.17692779
172vascular endothelial growth factor signaling pathway (GO:0038084)2.16466300
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.16059136
174negative regulation of nitric oxide biosynthetic process (GO:0045019)2.15597027
175regulation of macrophage cytokine production (GO:0010935)2.14503558
176positive regulation of gamma-delta T cell activation (GO:0046645)2.14063374
177positive regulation of tumor necrosis factor production (GO:0032760)2.13941766
178macrophage activation involved in immune response (GO:0002281)2.13327740
179antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.12369328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.08497016
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.16864415
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.06177287
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46766035
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.17381875
6* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07497765
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.05970663
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00664037
9E2F7_22180533_ChIP-Seq_HELA_Human2.89666556
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88576445
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.57252159
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49689640
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.49478839
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49290060
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49143922
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45279331
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37210088
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31437879
19SPI1_23547873_ChIP-Seq_NB4_Human2.23954555
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22238749
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.14530785
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12672598
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11030862
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09297508
25SCL_19346495_ChIP-Seq_HPC-7_Human2.09274608
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06635136
27GATA1_19941826_ChIP-Seq_K562_Human2.03170204
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02890900
29* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.99515050
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98838602
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94307442
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94025647
33ELK1_19687146_ChIP-ChIP_HELA_Human1.93411863
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.88126889
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77696492
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74735949
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72155172
38GATA2_19941826_ChIP-Seq_K562_Human1.71690416
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70092483
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69088776
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68678256
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66980243
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66164593
44* MYC_18555785_ChIP-Seq_MESCs_Mouse1.64956136
45* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64495068
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.61127654
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.60564714
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58970146
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57205141
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55245575
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54823709
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.54603291
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.54294589
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54143754
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53881315
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53006245
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52167548
58MYB_26560356_Chip-Seq_TH2_Human1.51526181
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47876640
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44973646
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43831304
62VDR_24763502_ChIP-Seq_THP-1_Human1.42953940
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41288753
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40153495
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39024089
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37796823
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37643244
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35630020
69* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31604567
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30894822
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30125420
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.29764300
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28937040
74PU_27001747_Chip-Seq_BMDM_Mouse1.28347431
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28143545
76HTT_18923047_ChIP-ChIP_STHdh_Human1.26098745
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25032192
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.24705933
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22803264
80GATA1_22025678_ChIP-Seq_K562_Human1.22511945
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22030321
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22030321
83RUNX_20019798_ChIP-Seq_JUKART_Human1.21659361
84TFEB_21752829_ChIP-Seq_HELA_Human1.21176774
85MYB_26560356_Chip-Seq_TH1_Human1.20994211
86MAF_26560356_Chip-Seq_TH1_Human1.19703781
87SPI1_23127762_ChIP-Seq_K562_Human1.19694528
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.19543261
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19471260
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19306401
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.18948138
92CJUN_26792858_Chip-Seq_BT549_Human1.18004388
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17153484
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16226199
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15749104
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15453013
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.14995771
98BRD4_25478319_ChIP-Seq_HGPS_Human1.13919809
99* ELK1_22589737_ChIP-Seq_MCF10A_Human1.13721095
100* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13561443
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13424711
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11910451
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.11539622
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11215415
105GATA3_26560356_Chip-Seq_TH2_Human1.10461815
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09817555
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09718157
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08915143
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08547741
110* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08049823
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07863041
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06004008
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05101735
114VDR_21846776_ChIP-Seq_THP-1_Human1.05027275
115SOX2_20726797_ChIP-Seq_SW620_Human1.04405264
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.04186603
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03825603
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02970488
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02268072
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02264008
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01267813
122VDR_24787735_ChIP-Seq_THP-1_Human1.01209506
123* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00761529
124DCP1A_22483619_ChIP-Seq_HELA_Human0.99745383
125GATA3_27048872_Chip-Seq_THYMUS_Human0.99256921
126E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98906424
127CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98245790
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98077978
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98074222
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96322459
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95091256
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94732399
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94210461
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.93610739
135* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91863187
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91061522
137* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88613264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.06478351
2MP0008004_abnormal_stomach_pH3.48555549
3MP0003279_aneurysm3.03014009
4MP0001835_abnormal_antigen_presentation2.78509556
5MP0003724_increased_susceptibility_to2.66822697
6MP0005503_abnormal_tendon_morphology2.47666262
7MP0006054_spinal_hemorrhage2.43703091
8MP0003436_decreased_susceptibility_to2.37775771
9MP0009785_altered_susceptibility_to2.35088858
10MP0002396_abnormal_hematopoietic_system2.30681181
11MP0002148_abnormal_hypersensitivity_rea2.22134338
12MP0002419_abnormal_innate_immunity2.17545923
13MP0001958_emphysema2.16959161
14MP0000343_altered_response_to2.05688100
15MP0005275_abnormal_skin_tensile1.84498149
16MP0001533_abnormal_skeleton_physiology1.84174850
17MP0004084_abnormal_cardiac_muscle1.84135998
18MP0000685_abnormal_immune_system1.82746914
19MP0005000_abnormal_immune_tolerance1.82185713
20MP0005025_abnormal_response_to1.78229988
21MP0000858_altered_metastatic_potential1.77623376
22MP0003566_abnormal_cell_adhesion1.77533947
23MP0002452_abnormal_antigen_presenting1.74332992
24MP0005464_abnormal_platelet_physiology1.73109569
25MP0001853_heart_inflammation1.72526642
26MP0004808_abnormal_hematopoietic_stem1.71595545
27MP0005671_abnormal_response_to1.69271125
28MP0001879_abnormal_lymphatic_vessel1.65546536
29MP0004272_abnormal_basement_membrane1.63257488
30MP0010368_abnormal_lymphatic_system1.62406225
31MP0005397_hematopoietic_system_phenotyp1.61723822
32MP0001545_abnormal_hematopoietic_system1.61723822
33MP0002166_altered_tumor_susceptibility1.56864705
34MP0002405_respiratory_system_inflammati1.55609027
35MP0005023_abnormal_wound_healing1.55490062
36MP0003186_abnormal_redox_activity1.53341736
37MP0001790_abnormal_immune_system1.50298425
38MP0005387_immune_system_phenotype1.50298425
39MP0001819_abnormal_immune_cell1.48607648
40MP0003303_peritoneal_inflammation1.48448828
41MP0003828_pulmonary_edema1.48434133
42MP0002420_abnormal_adaptive_immunity1.48153524
43MP0009384_cardiac_valve_regurgitation1.47501260
44MP0002723_abnormal_immune_serum1.47091460
45MP0003448_altered_tumor_morphology1.45113177
46MP0001800_abnormal_humoral_immune1.44456291
47MP0006082_CNS_inflammation1.43957790
48MP0005058_abnormal_lysosome_morphology1.43450676
49MP0002006_tumorigenesis1.40601590
50MP0000230_abnormal_systemic_arterial1.39210986
51MP0005390_skeleton_phenotype1.38674828
52MP0000767_abnormal_smooth_muscle1.37684463
53MP0008775_abnormal_heart_ventricle1.36788050
54MP0002933_joint_inflammation1.35894046
55MP0001542_abnormal_bone_strength1.34682861
56MP0003806_abnormal_nucleotide_metabolis1.33659544
57MP0005164_abnormal_response_to1.31271253
58MP0005083_abnormal_biliary_tract1.30023270
59MP0010352_gastrointestinal_tract_polyps1.29193456
60MP0000465_gastrointestinal_hemorrhage1.26882213
61MP0009333_abnormal_splenocyte_physiolog1.24580054
62MP0009763_increased_sensitivity_to1.23734082
63MP0009278_abnormal_bone_marrow1.23157504
64MP0002398_abnormal_bone_marrow1.20308765
65MP0000490_abnormal_crypts_of1.18952275
66MP0004036_abnormal_muscle_relaxation1.18950131
67MP0003091_abnormal_cell_migration1.17052484
68MP0009697_abnormal_copulation1.14773552
69MP0002998_abnormal_bone_remodeling1.13848190
70MP0002132_abnormal_respiratory_system1.13428252
71MP0000716_abnormal_immune_system1.13091051
72MP0001845_abnormal_inflammatory_respons1.12352998
73MP0008007_abnormal_cellular_replicative1.11760370
74MP0004883_abnormal_blood_vessel1.07290122
75MP0010155_abnormal_intestine_physiology1.07153577
76MP0009764_decreased_sensitivity_to1.06189948
77MP0005508_abnormal_skeleton_morphology1.05916295
78MP0003705_abnormal_hypodermis_morpholog1.05714185
79MP0003950_abnormal_plasma_membrane1.05419896
80MP0002429_abnormal_blood_cell1.05056167
81MP0000249_abnormal_blood_vessel1.04098073
82MP0000689_abnormal_spleen_morphology1.03440538
83MP0002722_abnormal_immune_system1.01501001
84MP0003183_abnormal_peptide_metabolism0.93368156
85MP0002295_abnormal_pulmonary_circulatio0.93067744
86MP0001851_eye_inflammation0.92709497
87MP0008469_abnormal_protein_level0.91611004
88MP0003638_abnormal_response/metabolism_0.90863341
89MP0003300_gastrointestinal_ulcer0.90747907
90MP0004947_skin_inflammation0.89512313
91MP0005167_abnormal_blood-brain_barrier0.89390424
92MP0005410_abnormal_fertilization0.88511284
93MP0003795_abnormal_bone_structure0.88292102
94MP0003075_altered_response_to0.86822834
95MP0004510_myositis0.85992341
96MP0001243_abnormal_dermal_layer0.84683894
97MP0005257_abnormal_intraocular_pressure0.84249669
98MP0003191_abnormal_cellular_cholesterol0.83971314
99MP0004134_abnormal_chest_morphology0.83680119
100MP0002877_abnormal_melanocyte_morpholog0.82701696
101MP0008260_abnormal_autophagy0.82686478
102MP0002060_abnormal_skin_morphology0.81970645
103MP0005623_abnormal_meninges_morphology0.81406590
104MP0003763_abnormal_thymus_physiology0.79809783
105MP0005084_abnormal_gallbladder_morpholo0.79088466
106MP0009765_abnormal_xenobiotic_induced0.78502381
107MP0001915_intracranial_hemorrhage0.77654770
108MP0001663_abnormal_digestive_system0.77318789
109MP0003866_abnormal_defecation0.77187333
110MP0003656_abnormal_erythrocyte_physiolo0.77156873
111MP0001614_abnormal_blood_vessel0.77109409
112MP0009379_abnormal_foot_pigmentation0.76121685
113MP0002128_abnormal_blood_circulation0.75561115
114MP0001544_abnormal_cardiovascular_syste0.75415320
115MP0005385_cardiovascular_system_phenoty0.75415320
116MP0005171_absent_coat_pigmentation0.74931973
117MP0005595_abnormal_vascular_smooth0.74859556
118MP0003172_abnormal_lysosome_physiology0.74326679
119MP0002113_abnormal_skeleton_development0.74119248
120MP0000372_irregular_coat_pigmentation0.73623509
121MP0005165_increased_susceptibility_to0.71065538
122MP0005174_abnormal_tail_pigmentation0.71019945
123MP0000733_abnormal_muscle_development0.70070337

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.86100075
2Gingival bleeding (HP:0000225)5.53161100
3Abnormal platelet function (HP:0011869)4.92770058
4Impaired platelet aggregation (HP:0003540)4.92770058
5Recurrent abscess formation (HP:0002722)4.70915740
6Protrusio acetabuli (HP:0003179)4.55073353
7Eczematoid dermatitis (HP:0000976)4.05072021
8Premature rupture of membranes (HP:0001788)4.01998847
9Recurrent bacterial skin infections (HP:0005406)3.96471573
10Vertebral compression fractures (HP:0002953)3.86387623
11Aortic aneurysm (HP:0004942)3.65536044
12Aortic dissection (HP:0002647)3.50562711
13Hyperlipoproteinemia (HP:0010980)3.46943888
14Conjunctival telangiectasia (HP:0000524)3.44712552
15Elevated erythrocyte sedimentation rate (HP:0003565)3.21121736
16Myositis (HP:0100614)3.18745092
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.17987251
18Petechiae (HP:0000967)3.06958969
19Hepatosplenomegaly (HP:0001433)3.00349919
20Vacuolated lymphocytes (HP:0001922)2.96489494
21Increased IgM level (HP:0003496)2.95366365
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.93112708
23Osteolytic defects of the hand bones (HP:0009699)2.93112708
24Abnormal pupillary function (HP:0007686)2.86967234
25Peritonitis (HP:0002586)2.86888402
26Abnormality of macrophages (HP:0004311)2.86135707
27Cervical subluxation (HP:0003308)2.83214923
28Cellulitis (HP:0100658)2.74032735
29Recurrent gram-negative bacterial infections (HP:0005420)2.73993163
30Beaking of vertebral bodies (HP:0004568)2.72518811
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.69027070
32Biconcave vertebral bodies (HP:0004586)2.66804874
33Soft skin (HP:0000977)2.66314826
34Dyschromatopsia (HP:0007641)2.63195397
35Thrombocytosis (HP:0001894)2.62089383
36Autoimmune hemolytic anemia (HP:0001890)2.62052734
37Spondylolisthesis (HP:0003302)2.55819595
38Stomatitis (HP:0010280)2.48420324
39Orchitis (HP:0100796)2.47411217
40Abnormality of the common coagulation pathway (HP:0010990)2.46041058
41Poikilocytosis (HP:0004447)2.44437139
42Paralysis (HP:0003470)2.43988153
43Recurrent skin infections (HP:0001581)2.42257792
44Syringomyelia (HP:0003396)2.42169689
45Spinal cord lesions (HP:0100561)2.42169689
46Mediastinal lymphadenopathy (HP:0100721)2.39053352
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.37314407
48Follicular hyperkeratosis (HP:0007502)2.36461630
49Dilatation of the ascending aorta (HP:0005111)2.34769661
50Vascular tortuosity (HP:0004948)2.34518656
51Obstructive lung disease (HP:0006536)2.33841380
52Chronic obstructive pulmonary disease (HP:0006510)2.33841380
53Purpura (HP:0000979)2.32677889
54Wormian bones (HP:0002645)2.32408286
55Autoimmune thrombocytopenia (HP:0001973)2.31182878
56Prolonged bleeding time (HP:0003010)2.22076095
57Pulmonary artery stenosis (HP:0004415)2.21391602
58Myocardial infarction (HP:0001658)2.21006793
59Nonimmune hydrops fetalis (HP:0001790)2.20764831
60Abnormality of skeletal muscle fiber size (HP:0012084)2.15280487
61Abnormality of the lumbar spine (HP:0100712)2.14459744
62Reduced antithrombin III activity (HP:0001976)2.12861974
63Mucosal telangiectasiae (HP:0100579)2.10495787
64Increased cerebral lipofuscin (HP:0011813)2.09363918
65Reticulocytopenia (HP:0001896)2.08760897
66Cerebral aneurysm (HP:0004944)2.08173672
67Recurrent fungal infections (HP:0002841)2.07792166
68Ankle contracture (HP:0006466)2.04782504
69Short middle phalanx of the 5th finger (HP:0004220)2.04488707
70Abnormality of iron homeostasis (HP:0011031)2.04276044
71Joint stiffness (HP:0001387)2.04178712
72Dysostosis multiplex (HP:0000943)2.03474789
73Abnormal platelet volume (HP:0011876)2.02974365
74Exertional dyspnea (HP:0002875)2.02860717
75Blue sclerae (HP:0000592)2.01140105
76Abnormal hemoglobin (HP:0011902)2.00041742
77Joint swelling (HP:0001386)1.99887607
78Nausea (HP:0002018)1.97638359
79Gingivitis (HP:0000230)1.97293251
80Increased density of long bones (HP:0006392)1.97278724
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96694484
82Poor head control (HP:0002421)1.95917648
83Basal ganglia calcification (HP:0002135)1.95278435
84Recurrent pneumonia (HP:0006532)1.94621369
85Aplastic anemia (HP:0001915)1.93955986
86Acanthocytosis (HP:0001927)1.93792492
87Osteomyelitis (HP:0002754)1.93522115
88Spinal rigidity (HP:0003306)1.93185800
89Spontaneous hematomas (HP:0007420)1.92573749
90Hematochezia (HP:0002573)1.91754065
91Polycythemia (HP:0001901)1.91259937
92Broad face (HP:0000283)1.90442933
93Optic neuritis (HP:0100653)1.90361968
94Retrobulbar optic neuritis (HP:0100654)1.90361968
95Periodontitis (HP:0000704)1.89652551
96Thoracolumbar scoliosis (HP:0002944)1.89229449
97Increased mean platelet volume (HP:0011877)1.87719897
98Abnormality of the acetabulum (HP:0003170)1.86932587
99Generalized aminoaciduria (HP:0002909)1.85614567
100Abnormality of lateral ventricle (HP:0030047)1.85566162
101Abnormality of T cell number (HP:0011839)1.85473162
102Delayed cranial suture closure (HP:0000270)1.85335914
103Arterial tortuosity (HP:0005116)1.82755415
104Recurrent lower respiratory tract infections (HP:0002783)1.82147739
105Interstitial pulmonary disease (HP:0006530)1.81259301
106Epistaxis (HP:0000421)1.81074194
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80843401
108Delayed closure of the anterior fontanelle (HP:0001476)1.80117254
109Patchy hypopigmentation of hair (HP:0011365)1.79504658
110Atrophic scars (HP:0001075)1.79147960
111Urticaria (HP:0001025)1.79091761
112Granulocytopenia (HP:0001913)1.79040331
1133-Methylglutaconic aciduria (HP:0003535)1.78735935
114Eosinophilia (HP:0001880)1.78267953
115Tinnitus (HP:0000360)1.78076485
116Abnormality of dentin (HP:0010299)1.77922546
117Increased variability in muscle fiber diameter (HP:0003557)1.77772507
118Prostate neoplasm (HP:0100787)1.77603368
119Leukocytosis (HP:0001974)1.77485432
120Abnormality of glycolipid metabolism (HP:0010969)1.76467342
121Abnormality of liposaccharide metabolism (HP:0010968)1.76467342
122Abnormality of glycosphingolipid metabolism (HP:0004343)1.76467342
123Axonal loss (HP:0003447)1.76241435
124Mitral stenosis (HP:0001718)1.76020101
125Systemic lupus erythematosus (HP:0002725)1.75255481
126Pathologic fracture (HP:0002756)1.75025091
127Renal Fanconi syndrome (HP:0001994)1.74474803
128White forelock (HP:0002211)1.74185636
129Hypergammaglobulinemia (HP:0010702)1.73054058
130Mucopolysacchariduria (HP:0008155)1.72424785
131Urinary glycosaminoglycan excretion (HP:0003541)1.72424785
132Vasculitis (HP:0002633)1.71809315
133Acute myeloid leukemia (HP:0004808)1.70717566
134Arterial thrombosis (HP:0004420)1.70591107
135Bruising susceptibility (HP:0000978)1.69867612
136Abnormal auditory evoked potentials (HP:0006958)1.69487607
137Distal lower limb amyotrophy (HP:0008944)1.69418692
138Reduced subcutaneous adipose tissue (HP:0003758)1.69364443
139Abnormality of transition element cation homeostasis (HP:0011030)1.68487593
140Abnormality of the pericardium (HP:0001697)1.68201998
141Increased serum ferritin (HP:0003281)1.68039596
142Type I transferrin isoform profile (HP:0003642)1.66667601
143Recurrent viral infections (HP:0004429)1.66237674
144Upper limb muscle weakness (HP:0003484)1.65662402
145Aortic valve stenosis (HP:0001650)1.65660761
146T lymphocytopenia (HP:0005403)1.65338310
147Abnormality of skull ossification (HP:0002703)1.65218746
148Slender build (HP:0001533)1.64023954
149Distal lower limb muscle weakness (HP:0009053)1.63455587
150Abnormality of the prostate (HP:0008775)1.58667202
151Episodic fever (HP:0001954)1.58488989
152Cardiovascular calcification (HP:0011915)1.55142592
153Abnormal delivery (HP:0001787)1.54777386
154Fragile skin (HP:0001030)1.52916450
155Cerebral hemorrhage (HP:0001342)1.50247970
156Amaurosis fugax (HP:0100576)1.49852244
157Type 1 muscle fiber predominance (HP:0003803)1.47401721
158Neoplasm of the rectum (HP:0100743)1.46598182
159Nemaline bodies (HP:0003798)1.45575807
160Chest pain (HP:0100749)1.45085308
161Encephalitis (HP:0002383)1.44964959
162Joint hemorrhage (HP:0005261)1.42802808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.59639546
2PIM23.30093139
3KDR2.52940858
4MYLK2.41337319
5TESK12.39115218
6BMX2.37170097
7BLK2.30877335
8KIT2.27831342
9TGFBR22.18130763
10TESK22.08005703
11TEC2.07800101
12TRPM72.01818240
13IRAK41.94146580
14NEK91.93636987
15LIMK11.92366152
16GRK51.89216328
17JAK31.79007808
18MAP3K141.71840948
19MAP4K11.70950016
20TBK11.68190472
21TYK21.55912766
22ERN11.52404799
23LRRK21.50815765
24PBK1.47943565
25TGFBR11.45113529
26TXK1.44661217
27PIK3CG1.44391157
28MAP2K31.42277571
29EIF2AK11.40195434
30BMPR21.39433776
31STK101.37686971
32ZAP701.36439049
33BTK1.36100051
34IKBKB1.32543148
35IRAK31.32179807
36ERBB31.30415755
37MAPKAPK31.30381330
38RPS6KA41.28805834
39FES1.27896849
40EIF2AK31.27428908
41GRK61.27083855
42TIE11.25811359
43ACVR1B1.24390421
44GRK71.23832098
45PIK3CA1.17246878
46MAP3K121.15170984
47TAOK21.12793092
48TTN1.07522902
49IKBKE1.05773569
50ILK1.05229803
51PAK41.04970707
52FLT31.03345379
53MAPKAPK51.02620836
54ADRBK11.01022878
55PIM10.99495299
56CSF1R0.99283755
57VRK20.99103161
58EIF2AK20.99053317
59PAK20.99051957
60MOS0.97622900
61ZAK0.96277901
62EPHA30.96210132
63MST40.93598234
64MAP3K30.91641663
65STK160.88383125
66PLK20.88120324
67ARAF0.87121017
68LYN0.82292894
69ABL20.81968581
70FGR0.81902481
71MAP3K110.78328201
72MATK0.77871732
73SCYL20.77255016
74PTK2B0.76151581
75BMPR1B0.75556846
76LCK0.73672852
77NUAK10.72347880
78HCK0.71782511
79BUB10.70485029
80RPS6KB20.70359161
81LMTK20.70254810
82VRK10.70213335
83STK40.70143529
84MAPKAPK20.69577100
85PRKG20.69492223
86CLK10.68502551
87CDK80.68407693
88MKNK10.68327261
89NLK0.67163061
90JAK10.66918000
91DMPK0.66243001
92SYK0.64554182
93DAPK30.63727489
94CSK0.61541917
95RIPK40.60244028
96ITK0.60229065
97EPHB20.59509898
98TAOK30.59187961
99DAPK10.59067469
100BCKDK0.58357154
101CHUK0.58129835
102CDK60.57633647
103ROCK10.55181604
104PRKD10.53767005
105EPHB10.49840206
106PDGFRB0.49561836
107STK240.49474795
108IGF1R0.48502288
109TRIB30.47469789
110PAK10.46881349
111PTK20.46003749
112MAP3K80.45997018
113FER0.45837938
114ADRBK20.45619826
115DDR20.45405319
116PRKCD0.44899562
117PDGFRA0.44451126
118PRKCQ0.41912626
119IRAK10.41324948
120CDK70.41217198
121ABL10.40800056
122MAP3K50.39662569
123SIK30.39111975
124WEE10.38882060
125YES10.38341887
126STK30.37505496
127MARK30.37170780
128PLK30.35033537
129BRSK20.34758108
130CAMKK20.32203374

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.45279986
2Ribosome_Homo sapiens_hsa030102.32224134
3Malaria_Homo sapiens_hsa051442.23255722
4Sulfur metabolism_Homo sapiens_hsa009202.12416662
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02250149
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93723620
7DNA replication_Homo sapiens_hsa030301.81470431
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.80307417
9Shigellosis_Homo sapiens_hsa051311.77461750
10Proteasome_Homo sapiens_hsa030501.76288845
11Hematopoietic cell lineage_Homo sapiens_hsa046401.75327368
12Legionellosis_Homo sapiens_hsa051341.73649027
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68771818
14Measles_Homo sapiens_hsa051621.67013225
15Fatty acid elongation_Homo sapiens_hsa000621.61634839
16Pertussis_Homo sapiens_hsa051331.61445922
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.61214451
18Other glycan degradation_Homo sapiens_hsa005111.57276045
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56986493
20Allograft rejection_Homo sapiens_hsa053301.56085021
21Viral myocarditis_Homo sapiens_hsa054161.51951257
22Osteoclast differentiation_Homo sapiens_hsa043801.50127524
23Protein export_Homo sapiens_hsa030601.48283638
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.47109251
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46643332
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45937965
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.45608877
28Apoptosis_Homo sapiens_hsa042101.43645028
29Phagosome_Homo sapiens_hsa041451.41320975
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.40822715
31p53 signaling pathway_Homo sapiens_hsa041151.40061819
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39683382
33ECM-receptor interaction_Homo sapiens_hsa045121.38840215
34Graft-versus-host disease_Homo sapiens_hsa053321.36525465
35Salmonella infection_Homo sapiens_hsa051321.34356101
36Toxoplasmosis_Homo sapiens_hsa051451.33741061
37Asthma_Homo sapiens_hsa053101.32323279
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27524192
39Lysosome_Homo sapiens_hsa041421.27053590
40Base excision repair_Homo sapiens_hsa034101.26958365
41TNF signaling pathway_Homo sapiens_hsa046681.26765131
42Tuberculosis_Homo sapiens_hsa051521.26690812
43Herpes simplex infection_Homo sapiens_hsa051681.26097785
44Endocytosis_Homo sapiens_hsa041441.24177920
45Rheumatoid arthritis_Homo sapiens_hsa053231.21695161
46Antigen processing and presentation_Homo sapiens_hsa046121.19506270
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16178905
48Staphylococcus aureus infection_Homo sapiens_hsa051501.14200071
49Focal adhesion_Homo sapiens_hsa045101.12986392
50Hepatitis B_Homo sapiens_hsa051611.12392630
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.11641588
52Homologous recombination_Homo sapiens_hsa034401.09007284
53Platelet activation_Homo sapiens_hsa046111.08331696
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.07796915
55Small cell lung cancer_Homo sapiens_hsa052221.07218293
56Influenza A_Homo sapiens_hsa051641.05808258
57Mismatch repair_Homo sapiens_hsa034301.05340843
58Collecting duct acid secretion_Homo sapiens_hsa049661.04788375
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03363269
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99670015
61Nucleotide excision repair_Homo sapiens_hsa034200.96355083
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95357224
63Amoebiasis_Homo sapiens_hsa051460.93238695
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90259332
65Primary immunodeficiency_Homo sapiens_hsa053400.88152999
66B cell receptor signaling pathway_Homo sapiens_hsa046620.87367761
67Cell cycle_Homo sapiens_hsa041100.87048085
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86632871
69Dilated cardiomyopathy_Homo sapiens_hsa054140.85840417
70Autoimmune thyroid disease_Homo sapiens_hsa053200.84930933
71Non-homologous end-joining_Homo sapiens_hsa034500.84861857
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84719353
73Adherens junction_Homo sapiens_hsa045200.84301231
74Gap junction_Homo sapiens_hsa045400.81816844
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81777022
76Proteoglycans in cancer_Homo sapiens_hsa052050.79847520
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79596608
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79310706
79Epstein-Barr virus infection_Homo sapiens_hsa051690.77801004
80TGF-beta signaling pathway_Homo sapiens_hsa043500.77768647
81Pyrimidine metabolism_Homo sapiens_hsa002400.77672494
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77363750
83Pentose phosphate pathway_Homo sapiens_hsa000300.76937232
84Chronic myeloid leukemia_Homo sapiens_hsa052200.76604423
85Nitrogen metabolism_Homo sapiens_hsa009100.76377668
86T cell receptor signaling pathway_Homo sapiens_hsa046600.74682997
87Pancreatic cancer_Homo sapiens_hsa052120.73980000
88Renin-angiotensin system_Homo sapiens_hsa046140.73324704
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73086220
90Chemokine signaling pathway_Homo sapiens_hsa040620.71714381
91HTLV-I infection_Homo sapiens_hsa051660.71512699
92RNA polymerase_Homo sapiens_hsa030200.71166589
93Systemic lupus erythematosus_Homo sapiens_hsa053220.70328593
94Acute myeloid leukemia_Homo sapiens_hsa052210.69478017
95Arachidonic acid metabolism_Homo sapiens_hsa005900.69357274
96Caffeine metabolism_Homo sapiens_hsa002320.68536782
97MicroRNAs in cancer_Homo sapiens_hsa052060.64406872
98Viral carcinogenesis_Homo sapiens_hsa052030.64029023
99HIF-1 signaling pathway_Homo sapiens_hsa040660.60758641
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60525366
101African trypanosomiasis_Homo sapiens_hsa051430.57278291
102Glycerolipid metabolism_Homo sapiens_hsa005610.56667342
103Glutathione metabolism_Homo sapiens_hsa004800.56296332
104N-Glycan biosynthesis_Homo sapiens_hsa005100.55102674
105Hepatitis C_Homo sapiens_hsa051600.54817769
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54457033
107Pathways in cancer_Homo sapiens_hsa052000.54082839
108Thyroid cancer_Homo sapiens_hsa052160.53293688
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52759103
110Fanconi anemia pathway_Homo sapiens_hsa034600.52642386
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52359269
112Spliceosome_Homo sapiens_hsa030400.51854940
113Parkinsons disease_Homo sapiens_hsa050120.49354014
114One carbon pool by folate_Homo sapiens_hsa006700.49113459
115Pancreatic secretion_Homo sapiens_hsa049720.48072837
116Purine metabolism_Homo sapiens_hsa002300.47760557
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47204361
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46435374
119Melanoma_Homo sapiens_hsa052180.46415354
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44510362
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43769714
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.43721730
123Serotonergic synapse_Homo sapiens_hsa047260.42375479
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40474781
125Rap1 signaling pathway_Homo sapiens_hsa040150.40010531
126Vibrio cholerae infection_Homo sapiens_hsa051100.36684508
127Galactose metabolism_Homo sapiens_hsa000520.36613858

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