RSU1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.28674843
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.92789788
3sleep (GO:0030431)4.78008705
4DNA double-strand break processing (GO:0000729)4.51142166
5protein neddylation (GO:0045116)4.50210182
6cytidine metabolic process (GO:0046087)4.40476258
7cytidine catabolic process (GO:0006216)4.40476258
8cytidine deamination (GO:0009972)4.40476258
9mannosylation (GO:0097502)4.06967825
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.98573144
11regulation of mitotic spindle checkpoint (GO:1903504)3.98573144
12chaperone-mediated protein transport (GO:0072321)3.98205602
13pyrimidine ribonucleoside catabolic process (GO:0046133)3.96992926
14RNA destabilization (GO:0050779)3.82393155
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.79534848
16rRNA methylation (GO:0031167)3.73513711
17mismatch repair (GO:0006298)3.61966544
18protein deneddylation (GO:0000338)3.60437848
19cullin deneddylation (GO:0010388)3.59709289
20adenosine metabolic process (GO:0046085)3.58636977
21somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.50861628
22isotype switching (GO:0045190)3.50861628
23somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.50861628
24rRNA modification (GO:0000154)3.50593136
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.50421424
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50421424
27preassembly of GPI anchor in ER membrane (GO:0016254)3.45361055
28ribosome assembly (GO:0042255)3.41331401
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40195915
30platelet dense granule organization (GO:0060155)3.25210001
31negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.23729812
32DNA catabolic process, exonucleolytic (GO:0000738)3.22699714
33regulation of regulatory T cell differentiation (GO:0045589)3.21447448
34cellular response to interleukin-15 (GO:0071350)3.19718584
35actin nucleation (GO:0045010)3.16955647
36endoderm formation (GO:0001706)3.12636018
37purine deoxyribonucleotide catabolic process (GO:0009155)3.11920835
38proteasome assembly (GO:0043248)3.08589909
39negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.06562641
40regulation of cellular amino acid metabolic process (GO:0006521)2.99806727
41water-soluble vitamin biosynthetic process (GO:0042364)2.95607795
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94546830
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93520855
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93520855
45tolerance induction (GO:0002507)2.90502439
46fucose catabolic process (GO:0019317)2.87798943
47L-fucose metabolic process (GO:0042354)2.87798943
48L-fucose catabolic process (GO:0042355)2.87798943
49regulation of fibroblast apoptotic process (GO:2000269)2.87278252
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87031946
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87031946
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87031946
53positive regulation of defense response to virus by host (GO:0002230)2.86949892
54maturation of 5.8S rRNA (GO:0000460)2.86294599
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85918709
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84337466
57inner mitochondrial membrane organization (GO:0007007)2.83774100
58deoxyribose phosphate catabolic process (GO:0046386)2.83404162
59protein K6-linked ubiquitination (GO:0085020)2.82692770
60leukocyte degranulation (GO:0043299)2.78920703
61negative regulation of ligase activity (GO:0051352)2.75335529
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75335529
63mast cell activation (GO:0045576)2.74371952
64fusion of sperm to egg plasma membrane (GO:0007342)2.74118294
65positive regulation of mRNA catabolic process (GO:0061014)2.73173357
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73114107
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73114107
68metallo-sulfur cluster assembly (GO:0031163)2.71917782
69iron-sulfur cluster assembly (GO:0016226)2.71917782
70mast cell activation involved in immune response (GO:0002279)2.71749244
71mast cell degranulation (GO:0043303)2.71749244
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70752137
73histone H2A acetylation (GO:0043968)2.69601665
74signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66936234
75signal transduction involved in DNA damage checkpoint (GO:0072422)2.66936234
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66716804
77somatic diversification of immunoglobulins (GO:0016445)2.66353048
78regulation of cellular extravasation (GO:0002691)2.65219767
79signal transduction involved in cell cycle checkpoint (GO:0072395)2.64736542
80deoxyribose phosphate biosynthetic process (GO:0046385)2.64139863
812-deoxyribonucleotide biosynthetic process (GO:0009265)2.64139863
82DNA demethylation (GO:0080111)2.60944287
83positive regulation of mRNA 3-end processing (GO:0031442)2.60884733
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60477739
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60360502
86negative regulation of meiotic cell cycle (GO:0051447)2.60343387
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60328441
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59472639
89negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59178488
90response to nitrosative stress (GO:0051409)2.58179263
91piRNA metabolic process (GO:0034587)2.58069135
92plasma membrane fusion (GO:0045026)2.57799143
93regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53273990
94positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53273990
95chromatin remodeling at centromere (GO:0031055)2.52631204
96base-excision repair, AP site formation (GO:0006285)2.52618558
97dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52552371
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52546455
99ATP synthesis coupled proton transport (GO:0015986)2.52107917
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52107917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55877019
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.12997648
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.66852127
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.43438702
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.28329955
6ZNF274_21170338_ChIP-Seq_K562_Hela3.19114813
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91753024
8VDR_23849224_ChIP-Seq_CD4+_Human2.90358311
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83632528
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63420913
11ELK1_19687146_ChIP-ChIP_HELA_Human2.51355539
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51141433
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43928063
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.38779046
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.25980535
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.22268189
17FOXP3_21729870_ChIP-Seq_TREG_Human2.21607019
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.14412572
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88069170
20IRF1_19129219_ChIP-ChIP_H3396_Human1.81395266
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80937488
22DCP1A_22483619_ChIP-Seq_HELA_Human1.77639701
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76174062
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73714065
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67595203
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67437230
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64580475
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63425978
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61954463
30MYC_18940864_ChIP-ChIP_HL60_Human1.61751931
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59682396
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55192319
33GATA3_26560356_Chip-Seq_TH2_Human1.53781488
34GABP_19822575_ChIP-Seq_HepG2_Human1.50353735
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47978535
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47746275
37RUNX_20019798_ChIP-Seq_JUKART_Human1.42256933
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.37142245
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.36943015
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36691346
41EWS_26573619_Chip-Seq_HEK293_Human1.35908440
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34577799
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34282809
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33722514
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33096388
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32570709
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.32570709
48TP53_22573176_ChIP-Seq_HFKS_Human1.31287054
49AR_20517297_ChIP-Seq_VCAP_Human1.30717991
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30640800
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29703531
52MYB_26560356_Chip-Seq_TH2_Human1.27377303
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.25160382
54FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24769527
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24247123
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.22679192
57E2F7_22180533_ChIP-Seq_HELA_Human1.22049142
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21090749
59GBX2_23144817_ChIP-Seq_PC3_Human1.20246796
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.19957003
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19616416
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15469406
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15130042
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13032458
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08049175
66GATA3_27048872_Chip-Seq_THYMUS_Human1.05780165
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05428390
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05243149
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04929773
70CBP_20019798_ChIP-Seq_JUKART_Human1.04929773
71SOX2_19829295_ChIP-Seq_ESCs_Human1.04525644
72NANOG_19829295_ChIP-Seq_ESCs_Human1.04525644
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.04394305
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04253685
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03981116
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03820559
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03816362
78P300_19829295_ChIP-Seq_ESCs_Human1.03583237
79VDR_22108803_ChIP-Seq_LS180_Human1.03201991
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02570718
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00918425
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.99036089
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94097768
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93906746
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92964416
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.92622378
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.92181180
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92132415
89GATA3_26560356_Chip-Seq_TH1_Human0.91631915
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91581797
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91238564
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90629477
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89236297
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88457493
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.87514888
96NANOG_20526341_ChIP-Seq_ESCs_Human0.87240199
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86314912
98TAF15_26573619_Chip-Seq_HEK293_Human0.86197657
99SPI1_23547873_ChIP-Seq_NB4_Human0.85483325
100NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85407595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.91804216
2MP0003724_increased_susceptibility_to3.67908615
3MP0005671_abnormal_response_to3.31505667
4MP0002009_preneoplasia2.84479413
5MP0009697_abnormal_copulation2.84243624
6MP0005167_abnormal_blood-brain_barrier2.82279836
7MP0002254_reproductive_system_inflammat2.67933468
8MP0006054_spinal_hemorrhage2.67080299
9MP0000465_gastrointestinal_hemorrhage2.66251823
10MP0004147_increased_porphyrin_level2.52380706
11MP0010368_abnormal_lymphatic_system2.48970334
12MP0005645_abnormal_hypothalamus_physiol2.47432258
13MP0006072_abnormal_retinal_apoptosis2.33587320
14MP0008995_early_reproductive_senescence2.31558329
15MP0003786_premature_aging2.30918635
16MP0008775_abnormal_heart_ventricle2.27642613
17MP0005464_abnormal_platelet_physiology2.19227931
18MP0002166_altered_tumor_susceptibility2.07330352
19MP0008877_abnormal_DNA_methylation2.01886307
20MP0003763_abnormal_thymus_physiology1.97739249
21MP0005646_abnormal_pituitary_gland1.85511433
22MP0001879_abnormal_lymphatic_vessel1.80473852
23MP0002933_joint_inflammation1.79793424
24MP0003436_decreased_susceptibility_to1.78584770
25MP0002006_tumorigenesis1.74196766
26MP0004782_abnormal_surfactant_physiolog1.67151560
27MP0005000_abnormal_immune_tolerance1.64557189
28MP0008872_abnormal_physiological_respon1.60300658
29MP0003806_abnormal_nucleotide_metabolis1.56692548
30MP0005253_abnormal_eye_physiology1.55638283
31MP0002736_abnormal_nociception_after1.53118884
32MP0002148_abnormal_hypersensitivity_rea1.52343841
33MP0010094_abnormal_chromosome_stability1.50305000
34MP0008004_abnormal_stomach_pH1.46552457
35MP0005075_abnormal_melanosome_morpholog1.45721307
36MP0002876_abnormal_thyroid_physiology1.40897555
37MP0009764_decreased_sensitivity_to1.39031934
38MP0009840_abnormal_foam_cell1.37668002
39MP0008058_abnormal_DNA_repair1.34270150
40MP0005084_abnormal_gallbladder_morpholo1.33922841
41MP0003718_maternal_effect1.33298063
42MP0006276_abnormal_autonomic_nervous1.32509873
43MP0003191_abnormal_cellular_cholesterol1.32359544
44MP0001529_abnormal_vocalization1.27128712
45MP0004215_abnormal_myocardial_fiber1.22804299
46MP0002822_catalepsy1.19238589
47MP0001835_abnormal_antigen_presentation1.13145955
48MP0004957_abnormal_blastocyst_morpholog1.11813443
49MP0001819_abnormal_immune_cell1.10464671
50MP0006036_abnormal_mitochondrial_physio1.10292782
51MP0003011_delayed_dark_adaptation1.10199068
52MP0000685_abnormal_immune_system1.09933582
53MP0008875_abnormal_xenobiotic_pharmacok1.09298362
54MP0002420_abnormal_adaptive_immunity1.07821215
55MP0004947_skin_inflammation1.07498479
56MP0005551_abnormal_eye_electrophysiolog1.06974920
57MP0002452_abnormal_antigen_presenting1.06930584
58MP0002723_abnormal_immune_serum1.06805141
59MP0001533_abnormal_skeleton_physiology1.04483603
60MP0000689_abnormal_spleen_morphology1.02372655
61MP0002398_abnormal_bone_marrow1.02005929
62MP0004133_heterotaxia0.99612474
63MP0005410_abnormal_fertilization0.98537712
64MP0001853_heart_inflammation0.97380445
65MP0004145_abnormal_muscle_electrophysio0.94681619
66MP0001919_abnormal_reproductive_system0.89895929
67MP0005083_abnormal_biliary_tract0.89303012
68MP0001501_abnormal_sleep_pattern0.87846066
69MP0001800_abnormal_humoral_immune0.86599189
70MP0005499_abnormal_olfactory_system0.86489010
71MP0005394_taste/olfaction_phenotype0.86489010
72MP0003866_abnormal_defecation0.82683299
73MP0006035_abnormal_mitochondrial_morpho0.82006207
74MP0002405_respiratory_system_inflammati0.81516468
75MP0002429_abnormal_blood_cell0.80679650
76MP0000372_irregular_coat_pigmentation0.79845320
77MP0001243_abnormal_dermal_layer0.79294755
78MP0002722_abnormal_immune_system0.79268765
79MP0000716_abnormal_immune_system0.78335749
80MP0009763_increased_sensitivity_to0.78219722
81MP0005365_abnormal_bile_salt0.74932178
82MP0000230_abnormal_systemic_arterial0.72835072
83MP0001986_abnormal_taste_sensitivity0.72704031
84MP0003638_abnormal_response/metabolism_0.72698598
85MP0001929_abnormal_gametogenesis0.72004662
86MP0001544_abnormal_cardiovascular_syste0.71606196
87MP0005385_cardiovascular_system_phenoty0.71606196
88MP0002419_abnormal_innate_immunity0.70483001
89MP0010155_abnormal_intestine_physiology0.70247802
90MP0005647_abnormal_sex_gland0.69489279
91MP0006138_congestive_heart_failure0.69392678
92MP0003186_abnormal_redox_activity0.69029298
93MP0000249_abnormal_blood_vessel0.68072655
94MP0001845_abnormal_inflammatory_respons0.68055314
95MP0005389_reproductive_system_phenotype0.67602619
96MP0001968_abnormal_touch/_nociception0.66479398
97MP0008260_abnormal_autophagy0.66326531
98MP0010386_abnormal_urinary_bladder0.64921130
99MP0000358_abnormal_cell_content/0.64898204
100MP0008007_abnormal_cellular_replicative0.64864086

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.58056853
2Stomatitis (HP:0010280)3.92672655
3Abnormal protein N-linked glycosylation (HP:0012347)3.67085638
4Abnormal protein glycosylation (HP:0012346)3.67085638
5Abnormal glycosylation (HP:0012345)3.67085638
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.67085638
7Congenital, generalized hypertrichosis (HP:0004540)3.58214447
8Type I transferrin isoform profile (HP:0003642)3.37400446
9Stomach cancer (HP:0012126)3.25362949
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.21834003
11Severe combined immunodeficiency (HP:0004430)3.19490771
12Hypoplasia of the pons (HP:0012110)3.04745349
13Abnormality of alanine metabolism (HP:0010916)3.02883966
14Hyperalaninemia (HP:0003348)3.02883966
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02883966
163-Methylglutaconic aciduria (HP:0003535)2.99931566
17Abnormality of the pons (HP:0007361)2.94235321
18Abolished electroretinogram (ERG) (HP:0000550)2.93993692
19Hepatocellular necrosis (HP:0001404)2.91349669
20Tongue fasciculations (HP:0001308)2.81177436
21Abnormality of eosinophils (HP:0001879)2.75769953
22IgM deficiency (HP:0002850)2.73435374
23IgA deficiency (HP:0002720)2.70835470
24Neonatal respiratory distress (HP:0002643)2.61578461
25Hepatic necrosis (HP:0002605)2.61159265
26Increased CSF lactate (HP:0002490)2.60471226
27Mitochondrial inheritance (HP:0001427)2.56522242
28Hematochezia (HP:0002573)2.52368134
29Acute encephalopathy (HP:0006846)2.50413693
30Combined immunodeficiency (HP:0005387)2.50011210
31Increased IgM level (HP:0003496)2.47779334
32Renal cortical cysts (HP:0000803)2.47748600
33Eosinophilia (HP:0001880)2.46941362
34Elevated erythrocyte sedimentation rate (HP:0003565)2.46728559
35Abnormality of B cell number (HP:0010975)2.41654539
36Methylmalonic acidemia (HP:0002912)2.38424288
37Increased serum lactate (HP:0002151)2.38327788
38Acute necrotizing encephalopathy (HP:0006965)2.37072329
39Abnormality of the anterior horn cell (HP:0006802)2.36351118
40Degeneration of anterior horn cells (HP:0002398)2.36351118
41T lymphocytopenia (HP:0005403)2.33220902
42Facial diplegia (HP:0001349)2.31985150
43Aplastic anemia (HP:0001915)2.31334039
44Hyperglycinemia (HP:0002154)2.30855689
45Muscle fibrillation (HP:0010546)2.29357363
46Abnormality of T cells (HP:0002843)2.26537007
47Abnormality of T cell number (HP:0011839)2.24832431
48Abnormal spermatogenesis (HP:0008669)2.21153280
49Abnormality of T cell physiology (HP:0011840)2.19059524
50Short tibia (HP:0005736)2.18907753
51B lymphocytopenia (HP:0010976)2.10913812
52Abnormality of the fovea (HP:0000493)2.10881302
53Fair hair (HP:0002286)2.10328315
54Lactic acidosis (HP:0003128)2.09782256
55Methylmalonic aciduria (HP:0012120)2.09046618
56Progressive microcephaly (HP:0000253)2.07836055
57Pancytopenia (HP:0001876)2.06680714
58Dry hair (HP:0011359)2.05884017
59Abnormal mitochondria in muscle tissue (HP:0008316)2.05592069
60Albinism (HP:0001022)2.03710159
61Thyroid-stimulating hormone excess (HP:0002925)2.03603947
62Medial flaring of the eyebrow (HP:0010747)2.03371497
63Increased serum pyruvate (HP:0003542)2.01823720
64Cerebellar dysplasia (HP:0007033)1.99084061
65Increased hepatocellular lipid droplets (HP:0006565)1.98950049
66Petechiae (HP:0000967)1.96640218
67Leukocytosis (HP:0001974)1.93906489
68Hypomagnesemia (HP:0002917)1.93501855
69Neoplasm of head and neck (HP:0012288)1.93288128
70Esophageal neoplasm (HP:0100751)1.93288128
71Cerebral palsy (HP:0100021)1.92038446
72Hypothermia (HP:0002045)1.91130040
73Neutropenia (HP:0001875)1.89651648
74Attenuation of retinal blood vessels (HP:0007843)1.88963282
75Inability to walk (HP:0002540)1.87586763
76Aplasia/Hypoplasia of the tibia (HP:0005772)1.86437867
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86118586
78Opisthotonus (HP:0002179)1.84496811
79Aplasia/Hypoplasia of the fovea (HP:0008060)1.83745537
80Hypoplasia of the fovea (HP:0007750)1.83745537
81Abnormality of serum amino acid levels (HP:0003112)1.83063902
82Colon cancer (HP:0003003)1.82670426
83Type II lissencephaly (HP:0007260)1.82122638
84Progressive macrocephaly (HP:0004481)1.81293489
85Thyroiditis (HP:0100646)1.81285118
86Pancreatic cysts (HP:0001737)1.81009486
87Poor head control (HP:0002421)1.80622304
88Abnormality of glycolysis (HP:0004366)1.80536055
89Prominent metopic ridge (HP:0005487)1.80358300
90Pulmonary fibrosis (HP:0002206)1.80289315
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79828307
92Nephronophthisis (HP:0000090)1.79294407
93Pendular nystagmus (HP:0012043)1.78361715
94Reduced antithrombin III activity (HP:0001976)1.77679404
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.76806482
96Congenital stationary night blindness (HP:0007642)1.76210351
97Lipid accumulation in hepatocytes (HP:0006561)1.76106596
98Abnormality of the renal cortex (HP:0011035)1.75792027
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74067750
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74067750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.49356187
2ZAK4.52781100
3MST43.32217395
4TAOK32.90580418
5TLK12.74921940
6TXK2.26687565
7TRIM282.22756170
8GRK12.17646571
9TEC2.09934000
10ACVR1B2.08725797
11GRK62.06877444
12BUB11.88037015
13TESK21.87144939
14SRPK11.85615466
15FES1.80514097
16BCKDK1.77426091
17PLK41.74460746
18MAP4K21.64065823
19BMPR1B1.58627795
20VRK11.58281979
21ERBB31.49117265
22EPHA31.43010362
23WNK31.39509635
24NUAK11.39256076
25LIMK11.29499478
26ZAP701.23191944
27WNK41.21843474
28FER1.20468400
29KDR1.16953995
30PLK31.16857575
31PLK21.14170614
32TESK11.13766968
33ADRBK21.13588089
34BCR1.11058828
35NEK11.08795819
36TTK1.05916801
37MAP2K21.03149403
38SIK30.90145214
39JAK10.88942215
40INSRR0.88850370
41TSSK60.86897936
42EPHB10.85823159
43IKBKE0.83388404
44RPS6KA50.81219415
45PTK2B0.80279951
46CAMKK20.79980058
47FLT30.79391806
48STK390.79355755
49OXSR10.77084157
50RPS6KA40.76576950
51DYRK30.74131130
52IKBKB0.73978012
53PBK0.73448950
54VRK20.73075113
55MAP3K140.72869015
56IRAK10.71358690
57SYK0.71354196
58CSNK1G30.68484161
59MYLK0.66057508
60STK160.64697872
61BRSK20.64691760
62EIF2AK30.63069638
63TBK10.62911775
64CSNK1G20.62445797
65CCNB10.60044138
66ITK0.58427717
67CSF1R0.57061072
68MKNK10.55052560
69IRAK40.54179314
70TGFBR10.52702832
71PINK10.52495965
72DAPK10.52293481
73HCK0.50540172
74KIT0.50058867
75WEE10.49929236
76CSNK1G10.48814618
77NLK0.47795845
78CDK80.46662566
79IGF1R0.46619663
80ADRBK10.46117741
81BTK0.46076487
82MAPKAPK30.44978744
83LYN0.44047567
84FGR0.43058641
85MATK0.42860760
86TGFBR20.42114886
87PIM10.41223186
88DYRK20.39561499
89MAP3K50.39521828
90EIF2AK20.37933363
91PHKG20.37663614
92PHKG10.37663614
93MUSK0.35225487
94LCK0.34251284
95CSNK1A1L0.34212364
96DAPK20.33800842
97PIK3CG0.33373421
98CSNK1D0.31755420
99CLK10.31292873
100PDK20.30819890

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.02519599
2Primary immunodeficiency_Homo sapiens_hsa053402.65984703
3RNA polymerase_Homo sapiens_hsa030202.37553557
4Mismatch repair_Homo sapiens_hsa034302.31892406
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20528610
6Protein export_Homo sapiens_hsa030602.15593940
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02790088
8Oxidative phosphorylation_Homo sapiens_hsa001902.02420887
9Non-homologous end-joining_Homo sapiens_hsa034501.99402105
10Homologous recombination_Homo sapiens_hsa034401.98844770
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.93577498
12Fatty acid elongation_Homo sapiens_hsa000621.89190339
13Parkinsons disease_Homo sapiens_hsa050121.84871456
14Fanconi anemia pathway_Homo sapiens_hsa034601.75287835
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72328562
16Basal transcription factors_Homo sapiens_hsa030221.68396413
17RNA degradation_Homo sapiens_hsa030181.64510584
18Base excision repair_Homo sapiens_hsa034101.62652617
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62517959
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61728011
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58235345
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56121295
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55486376
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51238745
25Selenocompound metabolism_Homo sapiens_hsa004501.47957224
26Nucleotide excision repair_Homo sapiens_hsa034201.44400146
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42460433
28DNA replication_Homo sapiens_hsa030301.41867315
29Propanoate metabolism_Homo sapiens_hsa006401.40483303
30Graft-versus-host disease_Homo sapiens_hsa053321.39781523
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38074202
32One carbon pool by folate_Homo sapiens_hsa006701.33789954
33Sulfur metabolism_Homo sapiens_hsa009201.32905555
34Linoleic acid metabolism_Homo sapiens_hsa005911.32014671
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30212918
36Antigen processing and presentation_Homo sapiens_hsa046121.29446060
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28476362
38Asthma_Homo sapiens_hsa053101.27145062
39Steroid biosynthesis_Homo sapiens_hsa001001.25661178
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22451444
41Glutathione metabolism_Homo sapiens_hsa004801.19912333
42Allograft rejection_Homo sapiens_hsa053301.18612657
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13403903
44Autoimmune thyroid disease_Homo sapiens_hsa053201.13146829
45Huntingtons disease_Homo sapiens_hsa050161.11003140
46Rheumatoid arthritis_Homo sapiens_hsa053231.08440510
47Regulation of autophagy_Homo sapiens_hsa041401.06365495
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05335979
49Pyruvate metabolism_Homo sapiens_hsa006201.04414281
50Pyrimidine metabolism_Homo sapiens_hsa002401.03301474
51Tryptophan metabolism_Homo sapiens_hsa003801.03093470
52Spliceosome_Homo sapiens_hsa030401.03035583
53Peroxisome_Homo sapiens_hsa041460.96031282
54Purine metabolism_Homo sapiens_hsa002300.95438097
55RNA transport_Homo sapiens_hsa030130.94792224
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.92977638
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91670315
58Sulfur relay system_Homo sapiens_hsa041220.87891775
59Fat digestion and absorption_Homo sapiens_hsa049750.87454345
60Phototransduction_Homo sapiens_hsa047440.85662565
61Ether lipid metabolism_Homo sapiens_hsa005650.85093514
62Arachidonic acid metabolism_Homo sapiens_hsa005900.84481439
63Hematopoietic cell lineage_Homo sapiens_hsa046400.83586559
64Alzheimers disease_Homo sapiens_hsa050100.82415732
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77838574
66Caffeine metabolism_Homo sapiens_hsa002320.77448963
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75890823
68Type I diabetes mellitus_Homo sapiens_hsa049400.73959201
69Collecting duct acid secretion_Homo sapiens_hsa049660.73513776
70Butanoate metabolism_Homo sapiens_hsa006500.71830595
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70346269
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70235295
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67343444
74Shigellosis_Homo sapiens_hsa051310.65404644
75Metabolic pathways_Homo sapiens_hsa011000.64903184
76Carbon metabolism_Homo sapiens_hsa012000.63839873
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61532358
78Olfactory transduction_Homo sapiens_hsa047400.59876646
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59106376
80Chemical carcinogenesis_Homo sapiens_hsa052040.58915205
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58613587
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57901041
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55242226
84Legionellosis_Homo sapiens_hsa051340.54993926
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53878676
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53487306
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51813915
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50933007
89Viral myocarditis_Homo sapiens_hsa054160.50858880
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49753878
91Nitrogen metabolism_Homo sapiens_hsa009100.49628487
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49468885
93Malaria_Homo sapiens_hsa051440.45924522
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45902953
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44879176
96Glycerolipid metabolism_Homo sapiens_hsa005610.42567785
97Fatty acid degradation_Homo sapiens_hsa000710.41375555
98Epstein-Barr virus infection_Homo sapiens_hsa051690.41368596
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40415776
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.39736482

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